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| Saturday, 16 June 2018 | Sunday, 17 June 2018 | Monday, 18 June 2018 | Tuesday, 19 June 2018 | Wednesday, 20 June 2018 | Thursday, 21 June 2018 |
Organizers: Daniel Sodickson, Joshua Trzasko
| N01 | Saturday 8:00 - 9:30 | Moderators: Dong Liang & Joshua Trzasko |
| 8:00 | What Exactly Is Deep Learning? |
| Bradley Erickson | |
Deep learning has captured much attention because in many image recognition tasks, it surpasses human performance. The potential for this technology in radiology is substantial, and this talk will describe some of the areas in which deep learning has been or soon will be applied to improve radiological practice. |
| 8:30 | Nuts & Bolts: How Does DL Work? |
| Thomas Pock | |
In this talk I will highlight connections between recent deep neural networks and classical methods for solving inverse problems in computer vision and image processing. I will focus on variational methods, graphical models which are known to be extremely flexible and also come along with a deep theoretical understanding. It turns out that many iterative algorithms for solving variational and graphical models can be unrolled and hence interpreted as layers in a deep neural network. The structure provided by these methods helps in reducing the number of model parameters and hence are less prone to overfitting. Moreover, the structure helps in interpreting the learned model parameters. I will show applications to stereo, motion and image reconstruction. |
| 9:00 | Limitations & Caveats of Deep Learning |
| Jeffrey Fessler | |
This presentation will describe data-driven methods for image reconstruction, including adaptive dictionaries, sparsifying transforms, convolutional neural network (CNN) models, and deep learning techniques. It will also discuss limitations and challenges of such methods. |
| 9:30 | Break & Meet the Teachers |
Organizers: Matthias Günther, Herbert Köstler
| N02 | Saturday 8:00 - 9:40 | Moderators: Michael Steckner & Susann Boretius |
| 8:00 | MRI: The Classical Description |
| Adrienne Campbell-Washburn | |
This lecture will cover the basics of MRI physics and image formation using the classical description. It will describe the basic concepts in magnetic moments, net magnetization of tissue and precession, as well as the manipulation of magnetization using RF pulses and magnetic field gradients to generate an image. Spin echoes and gradient echoes will be described along with the basics of T1 and T2 relaxation and their effect on image contrast. The Bloch equations will be used to summarize the evolution of magnetization and pulse sequence diagrams will be introduced to describe image formation. |
| 8:25 | MRI: A Systems Overview |
| Ralf Loeffler | |
MRI systems consist of 3 main components plus computer systems for user interaction, measurement control and signal processing. The 3 components are dedicated to static and gradient magnetic field generation, as well as the RF system for RF transmission and reception. While the purpose of the components has not changed over time, actual implementation has due to technological advances as well as demands by new MRI techniques. This talk will present the basic designs for the different components and discuss current implementations and potential future developments. |
| 8:50 | Bioeffects & Hazards from Static Field, Gradient, & RF Exposures |
| Johan van den Brink | |
This talk provides an overview of the MR safety risks and its scientific background |
| 9:15 | T1- & T2-Contrasts & Their Molecular Origin |
| Siegfried Stapf | |
This tutorial aims at introducing the molecular mechanisms behind the relaxation times, and possible pitfalls in their experimental determination. The focus of the contribution is on the field-dependence of relaxation times, the importance of parasitic effects, and on addressing non-exponential signal behavior in a quantitative manner. |
| 9:40 | Break & Meet the Teachers |
Organizers: Richard Buxton, Benedikt Poser, Joshua Shimony
| N03 | Saturday 8:00 - 9:40 | Moderators: Jonathan Polimeni & Joshua Shimony |
| 8:00 | BOLD Signal Physiology |
| Nicholas Blockley | |
To understand the strengths and limitations of functional MRI we must understand the interaction between the physiology of the brain and the physics of the measured signal. In this talk I will introduce the major physiological drivers of the Blood Oxygenation Level Dependent (BOLD) effect and describe how they affect the MRI signal. We can then use this knowledge to consider how stimulus evoked changes in the BOLD signal can be quantified as changes in oxygen metabolism. Whilst the BOLD signal is considered to be complex, through this understanding, we can observe it provides a rich source of physiological information. |
| 8:25 | Practical BOLD Acquisition Consideration |
| Kevin Murphy | |
In this educational course, we will explain basic BOLD scanning parameters; what they mean and how they interact with each other. We will discuss ways to improve BOLD time series quality using external recordings of physiology. Finally, we will touch on complementary MRI sequences that can further denoise BOLD fMRI time series. |
| 8:50 | Basic Analysis of Task-Based fMRI |
| Susan Francis | |
The general linear model (GLM) is one of the most commonly used methods to analyse task-based fMRI data. This talk outlines the basic concepts of the GLM, how it is used to study block and event-related paradigms and associated statistical analysis, as well as some example applications. The talk will then describe some limitations of a GLM, and briefly outline alternative methods to study task-based fMRI paradigms, such as the phase-encoding or travelling-wave method, and independent component analysis. |
| 9:15 | Introduction: Resting-State Functional Connectivity |
| Jonathan Power | |
"Functional connectivity" or "resting state" MRI has become commonplace in neuroscience over the last decade, and is increasingly used for clinical studies. This talk introduces some of the central concepts and findings in resting state fMRI. Earlier talks will cover fMRI data acquisition, this talk will mainly discuss data analysis and interpretation. This talk will open by introducing a convenient way to visualize fMRI scans, and then will use this approach to visually fractionate resting state fMRI data (via multi-echo analyses) into non-BOLD and BOLD signals. Only BOLD signals are typically thought to be of interest, but both kinds of signals are prevalent in fMRI scans, and both kinds of signals correlate with cognitive and behavioral variables of interest, making it important to recognize the signatures of each kind of signal. We will discuss the spatial and temporal manifestations of these signals and illustrate how these signals influence functional connectivity properties. We will illustrate how individual denoising techniques remove particular kinds of signals, and that no single denoising technique removes all unwanted signals from a dataset. Effective denoising requires multiple simultaneous approaches to best isolate BOLD signals of interest. |
| 9:40 | Break & Meet the Teachers |
Organizers: Gregor Adriany, Christoph Juchem, Mary McDougall, Greig Scott
| N04 | Saturday 8:00 - 9:30 | Moderators: Christoph Juchem & Sebastian Littin |
| 8:00 | MR Systems Overview |
| Hubertus Fischer | |
This educational talk provides a comprehensive overview on the building blocks of a clinical MR system. It concentrates on the essential functions to generate and to detect an MR signal, and how to achieve spatial resolution. It provides short look into the field generating unit, the RF transmit and receive system as well as the real time control unit. These topics outlined briefly as it is covered in detailed lectures of this session. The MR Systems overview is completed by covering the patient interface (patient table, communication and physiological triggering) and support functions as cooling, component supervision and RF shielding. |
| 8:30 | Magnets: Design, Manufacturing, Installation, Present & Future Technology |
| Ben Parkinson | |
This is an educational presentation to give ISMRM participants an understanding of the design and manufacturing processes required to produce a typical MRI magnet. The presentation explains the background to the magnetic field requirements for MRI and, using a worked example, explains typical MRI magnet design and the constraints under which that design occurs. In addition to the electromagnetic design, focus is placed on different cryogenic solutions for MRI magnets, and practical implementation of magnet design aspects. |
| 9:00 | Shimming: Superconducting & Passive Shims; Higher-Order Shims, Shim Arrays & Dynamic Shimming |
| Vincent Boer | |
Magnetic resonance imaging (MRI) and spectroscopy (MRS) rely on a strong and highly homogeneous magnetic field inside the scanner. Although magnets have a highly sophisticated design, there are still several techniques used to homogenize the field. Secondly, all biological samples will induce (dynamic) distortion in the field due to the tissue magnetic susceptibility. In this part of the course both passive shimming of a magnet, as well as active shimming with a subject in the magnet, will be discussed. Furthermore, several new advanced shimming strategies have emerged recently, some of the most promising ones will be discussed. |
| 9:30 | Break & Meet the Teachers |
Organizers: Eric Chang, Garry Gold, Emily McWalter, Edwin Oei, Philip Robinson
| S01 | Saturday 8:00 - 9:30 | Moderators: Paolo Felisaz & Matthew Koff |
| 8:00 | Rapid MR (3D, CS, Machine Learning) |
| Garry Gold | |
This presentation will cover new methods for rapid three-dimensional musculoskeletal imaging, including compressed sensing and machine learning methods. |
| 8:30 | Shoulder |
| Luis Beltran | |
This presentation will discuss imaging of the shoulder with an emphasis on operative management of anterior shoulder instability and rotator cuff tears. The learning objectives are to a) understand the mechanisms of injury and associated pathologies in anterior shoulder instability and rotator cuff tears, b) be familiar with current treatment guidelines for management of anterior shoulder instability and rotator cuff disease, c) recognize the normal and abnormal appearances of postoperative MRI studies for anterior shoulder instability surgery and rotator cuff repairs. I give permission to record this presentation. |
| 9:00 | Advanced Imaging in Hand & Wrist in Common Rheumatologically & Traumatic Conditions |
| Mikael Boesen | |
The lecture will show the conventional ways of imaging most common rheumatically and traumatic conditions in the hand and wrist and show the potential added value of new 3-dimensional and multi-parametric imaging technologies like dynamic contrast enhanced MRI (DCE-MRI), PET-CT and PET MRI, ultrasound, dual energy- and conebeam CT of the hand and wrist as promising methods to complement the imaging portfolio that adds further to the understanding and quantification of the pathophysiology, inflammatory load and morphological disease patterns in patients with rheumatoid arthritis (RA), psoriasis arthritis (PsA), crystal deposition diseases (Urate and CPPD), osteoarthritis (OA) and trauma. |
| 9:30 | Break & Meet the Teachers |
Organizers: Kathryn Fowler, Kartik Jhaveri, Lorenzo Mannelli, Valeria Panebianco, Scott Reeder, Reiko Woodhams
| S02 | Saturday 8:00 - 9:30 | Moderators: Dow-Mu Koh & Mark Schiebler |
| 8:00 | Current State of the Art |
| Hersh Chandarana | |
Abdominal or Body MRI suffers from number of limitations such as (1) slow and inefficient acquisition (2) sensitivity to motion related artifacts and (3) limited volumetric coverage and spatial resolution which are constrained by the breath-hold capacity of the patients. Various methods are used clinically and are being investigated to overcome these limitations in order to permit motion robust and rapid imaging of the abdomen. This talk will briefly discuss some of these methods for (1) fast imaging and (2) motion compensated imaging of the abdomen. |
| 8:22 | Non-Vascular Thoracic MRI |
| Constantine Raptis | |
Despite advances in imaging unit technology and research in the field, the utilization of thoracic MRI in regular clinical practice for noncardiac and nonangiographic applications has lagged behind expectations. While there are several clinical scenarios in which nonvascular thoracic MRI has a potential primary role, it is at present most frequently utilized as a problem solving modality to answer specific questions that cannot be determined via other imaging modalities, most commonly CT. The purpose of this talk is to explore commonly encountered situations in which thoracic MRI can be utilized to its fullest extent as a problem solving modality. |
| 8:44 | Body MR in ED |
| Bobby Kalb | |
Magnetic resonance imaging is increasingly being used in the emergency department setting, and offers potential advantages related to safety, diagnostic accuracy and efficiency, compared to the more commonly utilized modalities of CT and ultrasound. This presentation will describe methods for advantages of performing MRI in the ED for acute abdominopelvic pain and also PE, in addition to detailing suggested imaging protocols and techniques. |
| 9:06 | Whole-Body Imaging |
| Taro Takahara |
| 9:30 | Break & Meet the Teachers |
Organizers: Qiyong Gong, Kei Yamada
| S03 | Saturday 8:00 - 9:30 | Moderators: Qiyong Gong & Kei Yamada |
| 8:00 | Optimizing Acquisition for Robust MR Data |
| James Pipe |
| 8:22 | Standardization Challenges: Multi-Site |
| Thomas Chenevert |
| 8:44 | Population-Based Neuroimaging for Disease Etiology & Prediction |
| Meike Vernooij | |
Many neurological diseases, especially those occurring at older age, have a long subclinical phase during which a person is asymptomatic and does not seek medical attention. As a consequence, once symptoms manifest, in many instances the pathologic changes caused by the disease process are already advanced and mostly irreversible. To study disease in the asymptomatic stage, population-based studies are of great importance. Medical imaging applied in these studies, or ‘population imaging’ can, non- or minimally-invasively, show the changes that occur in the human body that may reflect either early disease, intermediate factors or risk indicators of disease. |
| 9:06 | Automatic Segmentation |
| Susumu Mori | |
In this presentation, the basic concept of anatomical segmentation is explained. This presentation first discusses about the importance of tissue segmentation for modern medical data analysis, in which difficult neurological conditions are often the target of the research. Then different types of segmentation approaches are explained. In the last section, an interesting paradox of the tissue segmentation, namely the lack of ground truth, is discussed in detail. This presentation should be informative for both method developers and users. |
| 9:28 | Break & Meet the Teachers |
Organizers: Ichio Aoki, Arvind Pathak
| S04 | Saturday 8:00 - 9:15 | Moderators: Christin Sander & Arvind Pathak |
| 8:00 | Introduction to MR Molecular Imaging |
| Peter Caravan |
| 8:25 | Multimodality Molecular Imaging for Beginners |
| Kristine Glunde | |
Multimodality molecular imaging applies imaging modalities beyond visualizing anatomy and morphology to include the ability of imaging disease-specific biomolecules and pathways in cancer, cardiovascular disease, and inflammation, among others. Imaging modalities used in molecular imaging are computed tomography (CT), magnetic resonance imaging (MRI), magnetic resonance spectroscopic imaging (MRSI), optical imaging, positron emission tomography (PET), single-photon-emission computerized tomography (SPECT), and ultrasound (US). This lecture will give an overview of the most important concepts and applications in multimodality molecular imaging for beginners. |
| 8:50 | Fundamentals of MR Relaxation for Molecular Imagers |
| Silvio Aime |
| 9:15 | Break & Meet the Teachers |
Organizers: Daniel Sodickson, Joshua Trzasko
| N01 | Saturday 10:00 - 11:30 | Moderators: Dong Liang & Joshua Trzasko |
| 10:00 | Applications: Image Acquisition & Reconstruction |
| Leslie Ying | |
Deep learning, as a powerful tool for artificial intelligence, has attracted a lot of attention in the MRI community. Recently deep learning has shown success in image acquisition and reconstruction. It has demonstrated some unique benefits over the existing methods. This course will teach how to use deep learning to perform image reconstruction from acquired k-space data. |
| 10:30 | Applications: Image Processing, Analysis & Interpretation |
| Daniel Rueckert | |
We will give an overview of the current state-of-the-art in deep learning for medical imaging applications such as segmentation and classification. In particular We will illustrate deep learning approaches for semantic image segmentation based on Convolutional Neural Networks (CNN). We will also show how adversarial approaches can be used to train CNNs that invariant to differences in the input data (e. g. different scanners and imaging protocols), and which does not require any labelled data for the test domain. Finally, we show some applications of CNNs in the context of image classification. |
| 11:00 | How to Jump-Start Your Deep Learning Research |
| Florian Knoll | |
This talk will provide a practical hands-on overview of how to get started in machine learning research from the point of view of an imaging lab. Common hurdles and pitfalls will be discussed via didactic examples from classification and reconstruction. The key differences of medical imaging data and computer vision applications will be highlighted. The talk will also discuss software frameworks and implementation, including code demos, which will be made available as open source. |
| 11:30 | Adjournment & Meet the Teachers |
Organizers: Matthias Günther, Herbert Köstler
| N02 | Saturday 10:00 - 11:15 | Moderators: Susann Boretius & Michael Steckner |
| 10:00 | Spatial Encoding (Introduction to k-Space, MRI as a Linear & Stationary System, PSF, MTF, Nyquist) |
| Tobias Wech | |
This presentation will provide an introduction to the k-space formalism. MRI will be approximated as a linear and stationary system and the point spread function as well as the modulation transfer function will be introduced as descriptive tools. Finally, the sampling-theorem of Nyquist and Shannon will be discussed with respect to classical MRI and newer techniques like compressed sensing or MR-fingerprinting. |
| 10:25 | How to Get the Optimal Signal-to-Noise |
| Claudia Hillenbrand | |
Acquiring an optimal image for clinical applications often means to strike the right balance between resolution, scan time, and signal to noise (SNR) in order to achieve the desired imaging objectives. The SNR is a fundamental measure of quality and performance in MRI. This presentation will review the basic principles relevant to signal and noise, measurement of SNR, factors influencing SNR, and discuss techniques that attempt to optimize SNR. |
| 10:50 | More than One RF-Pulse: Echoes & Phase Graphs |
| Matthias Weigel | |
The basic ideas and the resulting potential of the Extended Phase Graph (EPG) concept are described. It represents an elegant means for the pictorial and quantitative depiction of the resulting magnetization response in multi pulse sequences. EPGs also aid in the understanding and classification of echo generation. Based on these powerful properties and possibilities, the EPG concept has got a lot of attention during the last years. Additionally, the syllabus provides a collection of known and less known references. |
| 11:15 | Lunch & Meet the Teachers |
Organizers: Richard Buxton, Benedikt Poser, Joshua Shimony
| N03 | Saturday 10:00 - 11:40 | Moderators: Jonathan Polimeni & Joshua Shimony |
| 10:00 | Clinical fMRI: Presurgical Mapping |
| Alberto Bizzi |
| 10:25 | Clinical fMRI: Psychiatric Applications |
| Xiaoqi (Juliana) Huang | |
Psychiatric disorders traditionally have been classified as broad syndromes defined by symptoms rather than underlying neurobiologic substrate. The ability to visualize and quantify brain function, in vivo, noninvasively, is particularly important for psychiatric disorders. Recently, BOLD-fMRI has been widely used to identify brain functional or physiologic abnormalities in patients with psychiatric disorders. This lecture will introduce how the BOLD-fMRI can help us know more about psychiatric disorders in terms of mechanism, prediction and classification. This understanding will lay a foundation for building imaging biomarkers for psychiatric disorders. |
| 10:50 | ASL techniques for perfusion and/or BOLD imaging |
| Dimo Ivanov | |
Arterial spin labeling (ASL) enables non-invasive, quantitative MRI measurements of tissue perfusion, and has a broad range of applications including functional brain imaging. ASL can concurrently measure perfusion and blood oxygenation level dependent (BOLD) signal changes, which proves useful for investigating the brain’s physiology in health and disease. However, ASL suffers from limited temporal resolution and has a lower signal-to-noise ratio (SNR) compared to conventional BOLD imaging. In this lecture, the functioning, advantages, disadvantages and application areas of ASL will be summarized. Furthermore, the acquisition approaches and imaging parameters that influence ASL’s SNR and temporal resolution will be reviewed. |
| 11:15 | BOLD & EEG/MEG |
| Rene Scheeringa | |
Electrophysiological and hemodynamic measures are the two most prominent tools to study brain function non-invasively in humans. The two methodological approaches are thought to provide complementary information on how the brain functions. For this it is important to understand how these two methodologies are related. In this lecture I will mainly focus on how neural oscillations relate to BOLD/fMRI. I will explore how neural oscillations recorded both invasively, and with MEG and EEG relate to the BOLD signal and present my own work that relates neural oscillations to laminar specific changes in the BOLD signal and fMRI-based connectivity. |
| 11:40 | Adjournment & Meet the Teachers |
Organizers: Gregor Adriany, Christoph Juchem, Mary McDougall, Greig Scott
| N04 | Saturday 10:00 - 11:30 | Moderators: Christoph Juchem & Sebastian Littin |
| 10:00 | Gradient Coil Design Considerations, Manufacturing & Limitations |
| Richard Bowtell | |
Magnetic resonance imaging relies on the use of magnetic field gradients – that is a magnetic field, B (r) which varies linearly withposition, r, such that B (r) = G.r – to spatially encode the NMR signal. Such gradients are generated by passing currents throughspecially arranged coils of wire, placed on a former that surrounds the imaging subject. Three separate coils are needed in order toproduce a linear variation of the z-component of the magnetic field along each of the three Cartesian directions (x, y and z). Theperformance of the gradient coils and the amplifiers that are used to drive them dictates the kind of gradient waveforms that can beused in an MR scanner, particularly controlling the maximum gradient strength and rate of change of gradient with time that can be employed. Since the use of strong and rapidly switched gradients generally improves image quality and the speed of imagea cquisition, considerable benefits can result from optimising gradient coil performance. |
| 10:30 | Gradient Drivers: Amplifier Considerations, Power, Tuning & Cooling |
| Juan Sabate | |
Improvements in magnetic resonance imaging (MRI) require increased performance of the gradient amplifier. The objective of the presentation is to provide a description of the gradient amplifier functionality as part of the gradient system and to explain the design of the amplifier to meet the MRI requirements. PSDs reproduction fidelity and power needed for gradient fields requires switched amplifiers. The fidelity is achieved using digital control with high control bandwidth, feedforward and adequate compensations. New SiC semiconductors reduce losses keeping high performance and reducing volume and cost. The presentation provides detailed description of high-performance amplifier implementation and test results. |
| 11:00 | Eddy Currents & Interactions: Characterization & Compensation |
| S. Johanna Vannesjo | |
Magnetic resonance imaging relies on the ability to produce spatially linear magnetic fields (i.e. gradient fields) with a defined temporal evolution. This is achieved with room-temperature gradient coils, through which time-varying currents are passed. The resulting change in magnetic field will however induce eddy currents in nearby conducting structures according to Faraday’s Law of induction. This distorts the time-course of the gradient fields, leading to artefacts in imaging and spectroscopy. This presentation will give an overview of how eddy currents are generated, how to characterize them and how to compensate for their effects on the field. |
| 11:30 | Lunch & Meet the Teachers |
Organizers: Jenny Bencardino, Eric Chang, Garry Gold, Emily McWalter, Edwin Oei, Philip Robinson
| S01 | Saturday 10:00 - 11:30 | Moderators: Paolo Felisaz & Matthew Koff |
| 10:00 | Peripheral Nerves |
| Zehava Rosenberg | |
This talk will focus on MR imaging of peripheral nerve of the knee, ankle and foot. The talk will be subdivided into two parts. A. A discussion of general MRI features of entrapment neuropathies in the lower extremity. The listener will be provided with distinctive direct and indirect features of neuropathy. B. Focused discussion of specific nerves commonly susceptible to neuropathy, with a brief initial review of normal anatomy followed by MRI examples of common neuropathies. |
| 10:30 | Imaging Around Metal (Physics) |
| Kevin Koch |
| 11:00 | Hip |
| Andoni Toms |
| 11:30 | Lunch & Meet the Teachers |
Organizers: Kathryn Fowler, Kartik Jhaveri, Lorenzo Mannelli, Valeria Panebianco, Scott Reeder, Reiko Woodhams
| S02 | Saturday 10:00 - 11:30 | Moderators: Shetal Shah & Bachir Taouli |
| 10:00 | MRI Diffuse Liver Disease |
| Shahid Hussain |
| 10:22 | Imaging of the Portal Venous System |
| Reena Jha | |
Radiologists commonly encounter portal venous abnormalities. Understanding the varying appearances of acute and chronic portal venous thromboses and the associated changes of hepatic enhancement patterns is important for patient management. Furthermore, it is important to recognize that portal venous thrombosis may change the contour of the liver, and simulate cirrhosis. Congenital and acquired chronic portal vein thrombosis may lead to the development of hepatic masses, and may alter the appearance of the bile ducts and mimic malignancy. |
| 10:44 | Liver Lesions: Malignant |
| Thomas Vogl | |
In summary, liver imaging has found its place in the reality of cross-sectional imaging. The use of contrast agent is still controversial. Here further developments are directed in order to improve the qualitative and quantitative information. Artificial intelligence techniques will integrate multiparametric MRI information in the concept of radionics and radiogenomics. |
| 11:06 | Biliary Imaging & Pathology |
| Mi-Suk Park | |
In this talk, I will present differential diagnosis of biliary lesions based on imaging phenotypes with pathologic correlation. And then TNM staging with pathologic correlation will be reviewed based on the 8th edition of NCCN guidelines. |
| 11:28 | Lunch & Meet the Teachers |
Organizers: Qiyong Gong, Kei Yamada
| S03 | Saturday 10:00 - 11:30 | Moderators: Qiyong Gong & Kei Yamada |
| 10:00 | Lesion Detection (MS, Vascular Lesions) |
| Shingo Kakeda | |
The role of brain MRI in diagnosis of multiple sclerosis (MS) and vascular lesions is well established, and the recently developed MR techniques, including synthetic MRI, myelin map with q-Space diffusion MRI, susceptibility-weighted imaging (SWI) and quantitative susceptibility mapping (QSM), further improve the diagnostic value in a research and clinical routine setting. This course will introduce the recent data pertaining to the use of new MR techniques in assessing MS lesion and small vascular lesions (cerebral microinfarcts). |
| 10:22 | Graph-Theory Brain Network Analysis |
| Yong He |
| 10:44 | Adversarial generative network - new generation of image generation |
| Masayuki Ohzeki | |
We introduce a concept of the generative adversarial network and consider its possibility of medical application.
|
| 11:06 | Machine Learning II (For Medicine) |
| Bradley Erickson | |
This session will describe the basic concepts of machine learning, both traditional machine learning and deep learning. Particular emphasis will be placed on how ML methods can give results that appear good, but may not be correct or representative of real world performance. |
| 11:28 | Adjournment & Meet the Teachers |
Organizers: Ichio Aoki, Arvind Pathak
| S04 | Saturday 10:00 - 11:40 | Moderators: Christin Sander & Arvind Pathak |
| 10:00 | MR Spectroscopy - The Forgotten Molecular Imaging Modality |
| Robin de Graaf | |
MR-based molecular imaging typically relies on the high detection sensitivity of water to indirectly observe the underlying molecular and cellular processes. The ubiquitous presence of water demands that image contrast and specificity is obtained through molecular imaging probe design. MR spectroscopy uses the intrinsic specificity provided by the chemical shift to allow detection of a wide range of metabolites and metabolic pathways. When combined with spatial imaging gradients, MR-based metabolic imaging can provide a unique and complementary addition to the arsenal of molecular imaging techniques. |
| 10:25 | Principles of Probe Design for Molecular Imagers |
| Horacio Cabral | |
Molecular imaging allows the visualization of biological events in real-time at tissue, cellular and subcellular levels in living systems by merging conventional imaging techniques with probes designed to report the expression of biomarkers or variations in physiological factors. Successful molecular imaging agents should provide high contrast intensity with low noise-to-signal ratio at the target in vivo for sufficient time. Herein, I recapitulate the principles for designing effective molecular imaging probes for various imaging modalities, and provide fundamental strategies for the development of these probes and their application in biology, diagnosis and therapy. |
| 10:50 | Introduction to "Cellular" Molecular Imaging |
| Ben Bartelle |
| 11:15 | How to Design a Molecular Imaging Experiment |
| Emmanuel Barbier | |
This course will address the steps that a beginner should follow to develop a molecular imaging experiment in small animals: after setting the target and choosing the appropriate animal model, we will evaluate the pros and cons of existing imaging modalities, with a focus on MRI data acquisition and integration during post-processing. Examples will be taken from oncology and neuroscience. |
| 11:40 | Adjournment & Meet the Teachers |
Organizers: Jennifer Keegan, Dwight Nishimura
| N01 | Saturday 13:15 - 14:45 | Moderators: Jayashree Kalpathy-Cramer & Jennifer Keegan |
| 13:15 | Designing Studies of Diagnostic Imaging |
| Susan Mallett |
| 13:40 | Basic Concepts in Measurement Error |
| Alice Sitch |
| 14:05 | Break & Meet the Teachers |
| 14:20 | Study Designs and Bias |
| TBD |
| 14:45 | Monitoring Studies |
| Alice Sitch |
| 15:10 | Break & Meet the Teachers |
Organizers: Matthias Günther, Herbert Köstler
| N02 | Saturday 13:15 - 14:55 | Moderators: Patricia Figueiredo & Maxim Zaitsev |
| 13:15 | Spin Echo, RARE, GRASE |
| Jürgen Schneider | |
Starting from the basic spin-echo sequence, this talk will subsequently introduce more advanced imaging sequence, which are based on multiple refocusing pulses. Advantages and technical challenges for these sequences will be discussed, and example applications will be given. |
| 13:40 | Gradient Echo Sequences |
| Oliver Bieri | |
The fundamental signal generation in magnetic resonance imaging (MRI) sequences is based on the principle of either spin echoes or gradient echoes or a combination of the two. This course elucidates concepts and basic properties of gradient echo methods with a special focus on fast gradient echo sequences. |
| 14:05 | Basic Preparation of Image Contrast |
| Ute Goerke | |
The lecture covers the basic principles of the molecular origin of image contrast, how the choice of sequence type and imaging parameters influence contrast and the implementation of additional sequence components to create a specific image contrast. The theory behind the presented concepts will be discussed and illustrated with examples from relevant applications. |
| 14:30 | RF Pulse Design |
| Markus Barth | |
This course part will cover the concepts to understand the theory and implementation of radiofrequency (RF) pulses including the small tip angle tip angle approximation, the Shinnar-LeRoux (SLR) algorithm and numerical methods. |
| 14:55 | Break & Meet the Teachers |
Organizers: Richard Buxton, Benedikt Poser, Joshua Shimony
| N03 | Saturday 13:15 - 14:30 | Moderators: Shella Keilholz & Benedikt Poser |
| 13:15 | Connectivity: Analysis |
| Mark Lowe | |
An overview of current analysis methods for assessing functional connectivity using resting state fMRI data. A brief review of important preprocessing steps necessary for quality resting state data as well as various complex network analysis methods, including structural equation modeling, clustering methods and graph theoretic methods. Dynamic functional connectivity methods are briefly discussed. |
| 13:40 | A Multi-modal Parcellation of Human Cerebral Cortex |
| Matthew Glasser | |
We will discuss the Human Connectome Project’s multi-modal cortical parcellation version 1.0—the data acquisition and analysis requirements, how the parcellation was made, and how it can be applied to individuals. This state of the art map of the cerebral cortex was made possible by using exceptionally high quality MRI data precisely aligned across individuals. Cortical areal boundaries were identified when visible in multiple modalities and areas were painstakingly related to the neuroanatomical literature. A machine learning classifier was then trained to automatically identify each cortical area based on its multi-modal fingerprint in individual subjects, replicating the parcellation. |
| 14:05 | fMRI Connectivity, Depression, and Anhedonia: a Bayesian network analyses in Schizophrenia, Bipolar Disorder, ADHD, and Healthy Controls |
| Ariana Anderson | |
Although MRI, fMRI, and genetic biomarkers have been implicated in depression, it is unclear how much these measures illuminate the disorder compared to behavioral and demographic measurements. Using these measurements, we predicted depressive symptoms to compare the effect size of these modalities. In 119 subjects with a diagnosis of Bipolar disorder (n=43), Schizophrenia (n=39), and ADHD (n= 37), random forests models predicted both generalized depression (Hopkin Symptom Checklist) and anhedonia-specific measures (Chapman Scales for Physical and Social Anhedonia) using genetic, structural MRI volumetric measures, resting-state fMRI network connectivity measures, demographic features, and behavioral assessments measures. We found that comorbid behavioral symptoms accounted for nearly 75% of predictive ability. When removing behavioral assessments, only 8.75% of variance in the depression symptom scores were predictable from neuroimaging, demographic, genetic measures. Demographics retained the strongest predictive ability. |
| 14:30 | Break & Meet the Teachers |
Organizers: Gregor Adriany, Christoph Juchem, Mary McDougall, Greig Scott
| N04 | Saturday 13:15 - 14:45 | Moderators: Christoph Juchem & Sebastian Littin |
| 13:15 | RF Transmit: Power Delivery, Decoupling & Duty Cycle |
| Natalia Gudino | |
This talk will cover different RF engineering methods used in the design and implementation of transmit systems currently available in clinical MRI settings and research sites. |
| 13:45 | RF Receivers: Signal Detection Chain, Digitization, System Noise Figures - from MRI Signal to Bits |
| Nicola De Zanche | |
This lecture covers the components of the RF chain from detection of the signal in the RF coil to its final representation as digital data. Each component is described and its effect on signal strength and quality is discussed. |
| 14:15 | Controlling the MR Subsystems: Pulse Sequence Control, Waveform Generation & Real-Time Control |
| Juan Santos | |
Lecture for scientists and clinicians interested in learning more details about the core software structure and control systems of an MRI machine. |
| 14:45 | Break & Meet the Teachers |
Organizers: Eric Chang, Garry Gold, Emily McWalter, Edwin Oei, Philip Robinson
| S01 | Saturday 13:15 - 14:45 | Moderators: Emily McWalter & Alissa Burge |
| 13:15 | Knee |
| Jung-Ah Choi | |
The purpose of lecture is to review and apply current and emerging techniques in MR imaging of the knee joint. |
| 13:45 | Foot/Ankle |
| James Linklater |
| 14:15 | Body composition, Lipid & Fat Imaging |
| Martin Torriani | |
Body composition can be assessed using multiple imaging modalities, such as CT, MRI, MRS and PET, and provide valuable information in conditions associated with abnormal lipid distribution. |
| 14:45 | Break & Meet the Teachers |
Organizers: Kathryn Fowler, Kartik Jhaveri, Lorenzo Mannelli, Valeria Panebianco, Scott Reeder, Reiko Woodhams
| S02 | Saturday 13:15 - 14:45 | Moderators: Jeffrey Brown & Naranamangalam Jagannathan |
| 13:15 | DWI for the Pancreas |
| Yashihiko Fukukara | |
DWI reflects changes in water mobility caused by interactions with cell membranes, macromolecules, and alterations to the tissue environment. It enables quantitative assessment of tissue diffusivity based on the apparent diffusion coefficient. Advances in image quality have made DWI a routinely implemented clinical protocol for the pancreas, as it can be performed relatively quickly and has excellent contrast resolution without the administration of contrast agents. DWI is a promising technique for the evaluation of pancreas tumors, including detection, characterization, monitoring treatment response, and prediction of patient prognosis. Its role in the above mentioned clinical settings will be discussed. |
| 13:37 | MR Enterography |
| Jordi Rimola | |
In this lecture we are going to discuss the key signs for detecting and grading active inflammation and characterizing complications, in particular strictures. We also highlight the current limitations of the technique and potential ways to overcome them. |
| 13:59 | MRI of Perianal Fistula |
| Ellie Korngold |
| 14:21 | Advances in Abdominal Imaging |
| Shreyas Vasanawala |
| 14:45 | Break & Meet the Teachers |
Organizers: Qiyong Gong, John Port
| S03 | Saturday 13:15 - 14:45 | Moderators: Qiyong Gong |
| 13:15 | Overview of MR Brain Methods |
| Kelvin Lim | |
Magnetic resonance has the advantage of having multiple acquisition methods and parameters that result in the collection of different types of information. This capability to collect multimodality information has made MR a critical tool for the study of neuropsychiatric disorders. This presentation will provide an overview of the multiple modalities available with MR. Part 1 will provide an intuitive conceptual framework for comparing and contrasting the different modalities available with MR. in Part 2, we will use this framework to compare and contrast the major MR modalities, focussing on the following categories of information: Anatomy, Diffusion, Function and Spectroscopy. |
| 13:45 | MR of Aging and Dementia |
| Prashanthi Vemuri | |
Universally observed cognitive decline in the elderly due to the pathological aging of the brain will have a significant impact on public health. This presentation will aid in understanding 1) the recent advances in the field of aging and dementia; 2) MR methodologies that are used for the evaluation of age and dementia related brain changes specifically due to Alzheimer’s disease pathophysiology and cerebrovascular disease as tools for diagnosis, prognosis, measuring disease progression, and mechanistic inferences into the disease process in cognitive aging and dementia; and 3) open questions and directions in this research area for MR. |
| 14:15 | MR of Depression/Bipolar Disorders |
| Su Lui | |
Depression is a heterogeneous condition. Some patients who meet symptom criteria for major depressive episode (MD) also identify with bipolar disorder (BD). Until now, there are no objective markers for differentiating MD and BD, and also for early diagnosis, risk evaluation and treatment options. We reviewed the MRI findings of structural and functional alternations in MD and BD at the time of premorbid, before treatment and after treatment with multi-modal MRI image data. The research above provided the possibility of diagnosis, finding out high-risk individuals before disease and predicting treatment effects by MRI. |
| 14:45 | Break & Meet the Teachers |
Organizers: Natalie Serkova, Damian Tyler
| S04 | Saturday 13:15 - 14:45 | Moderators: Natalie Serkova & Damian Tyler |
| 13:15 | PET-MRI: The Technical Aspects |
| TBD |
| 13:37 | PET-MRI: The Application |
| Andreas Kjaer |
| 13:59 | Hyperpolarized 13C MRI: The Technical Aspects from Hamiltonian to Homo sapien |
| Jack Miller | |
We will examine the mechanistic details behind dissolution-Dynamic Nuclear Polarisation with small molecules for in vivo applications, and additionally discuss some of the technical challenges that arise in the design of pulse sequences to use the magnetisation that the technique generates. |
| 14:21 | Hyperpolarized 13C MRI: The Application |
| Jessica Bastiaansen |
| 14:43 | Break & Meet the Teachers |
Organizers: Jennifer Keegan, Dwight Nishimura
| N01 | Saturday 15:15 - 16:30 | Moderators: Jayashree Kalpathy-Cramer & Jennifer Keegan |
| 15:15 | Understanding Variability Including Inter-reader and Intra-reader Studies |
| Alice Sitch |
| 15:45 | Advanced Methods & Reporting |
| Susan Mallett |
| 16:15 | Adjournment & Meet the Teachers |
| 16:45 | Reporting Guidelines and Making Your Research Useful |
| TBD |
Organizers: Matthias Günther, Herbert Köstler
| N02 | Saturday 15:15 - 16:30 | Moderators: Patricia Figueiredo & Maxim Zaitsev |
| 15:15 | Susceptibility, Flow, Chemical Shift, Motion Artifacts & Imaging |
| Frederik Laun | |
Following this lecture, the audience will understand the effect of magnetic susceptibility, flow, chemical shift, and motion on MRI. They will be able to use this knowledge to identify and minimize related artifacts or, alternatively, to measure the underlying effects. |
| 15:40 | EPI as Workhorse for Diffusion, Perfusion, fMRI.... |
| Penny Gowland | |
Traditionally MRI is used to produce high quality, high resolution images of the human anatomy. However it is also has the capacity to capture a range of dynamic processes in the body, and one of the best imaging sequences for doing this is EPI. This talk will consider the advantages and disadvantages of EPI as a readout scheme, its use in quantitative imaging and in imaging dynamic processes. |
| 16:05 | Arbitrary Trajectories: ACQ, Gradients, Reconstruction, Artifacts |
| S. Johanna Vannesjo | |
Cartesian k-space sampling on a regular grid provides optimal conditioning for image reconstruction. Yet, there are several reasons why it can be beneficial to deviate from the regular Cartesian sampling scheme. It may for example be to achieve faster coverage of k-space, to make use of self-navigating properties, to shape the point-spread function or to reduce the echo time. The most commonly used non-Cartesian acquisitions are radial and spiral sampling, but a large range of advanced sampling schemes have been explored. This presentation will cover basic considerations related to arbitrary sampling, from gradient waveform design to image reconstruction. |
| 16:30 | Adjournment & Meet the Teachers |
Organizers: Richard Buxton, Benedikt Poser, Joshua Shimony
| N03 | Saturday 15:15 - 16:55 | Moderators: Shella Keilholz & Benedikt Poser |
| 15:15 | BOLD Acquisition Beyond 2D EPI |
| Wietske van der Zwaag | |
Although the vast majority of fMRI studies is still performed with 2D-EPI, there are several other BOLD-sensitive sequences, available on most clinical platforms, that may perform better. The main alternatives to 2D-EPI are 3D-EPI and SMS-EPI, although EVI, MR-encephalography, ME-EPI and SE-EPI have also recently gathered interest. All these sequences will be discussed and compared to one another in terms of their strengths, weaknesses and artifacts. Specific situations in which a specific sequence would be preferred will be used to highlight the relevant strong points. |
| 15:40 | fMRI Acquisition Beyond BOLD |
| J. Jean Chen | |
Although the BOLD signal has been the workhorse of fMRI, BOLD fMRI is limited by its intrinsic T2/T2* sensitivity and exhibits exaggerated weighting towards large veins. Moreover, the BOLD signal is a relative rather than quantitative measure of brain function that depends on the interplay of perfusion and oxygenation, leaving room for ambiguous interpretation. This talk will summarize recent efforts to explore alternative fMRI methods, including those based on blood flow, blood volume and blood oxygenation. The applications of these methods in both task-based and resting-state studies will be introduced. |
| 16:05 | High Resolution Applications: Cortical Layers |
| Jonathan Polimeni | |
Laminar fMRI refers to the study of functional activation within the cerebral cortex, with the goal of detecting distinct functional activity within cortical layers, and is an emerging application of high-resolution fMRI. Although individual cortical layers cannot be resolved with current human fMRI techniques, and hemodynamic coupling and variation of fMRI signals across layers is incompletely understood, because of the roles cortical layers play in distributed neuronal processing measuring layer-specific activation is key to understanding brain circuitry, which motivates work towards surmounting these difficulties. This presentation will introduce laminar fMRI, summarize recent advances, and focus on challenges faced when interpreting these data. |
| 16:30 | Combining fMRI with Advanced Neurotechniques |
| Xin Yu | |
By combining fMRI with fiber optic calcium recording and optogenetics, as well as two-photon microscopy or |
| 16:55 | Adjournment & Meet the Teachers |
Organizers: Gregor Adriany, Christoph Juchem, Mary McDougall, Greig Scott
| N04 | Saturday 15:15 - 16:45 | Moderators: Christoph Juchem & Sebastian Littin |
| 15:15 | Multi-Modality Imaging in an MRI Scanner: Making the Systems Compatible |
| Chrit Moonen | |
Focused ultrasound (FUS) is increasingly used for therapy. It can be guided by MRI, ultrasound imaging, or both. Here, three examples are elaborated how MRI and ultrasound imaging can be used simultaneously and beneficially for guiding FUS: 1) Tracking of beampath obstructions (ribs); 2) Motion evaluation; 3) Monitoring of cavitation during drug delivery with microbubbles. |
| 15:45 | Basic MR Safety: SAR to Temperature, Power Deposition/Monitoring, Effects of RF Coils & Field Strength |
| Nicolas Boulant | |
The advent of parallel transmission at high field has led to many studies aiming at quantifying more accurately the Specific Absorption Rate (SAR)/temperature aspects while understanding in more details the risks involved in MRI experiments. This talk gives a review of different techniques employed for SAR calculations, their validations and real-time supervision. Safety margins arising from each step of the evaluation chain are described and future directions for temperature evaluation are presented. |
| 16:15 | Peripheral Nerve Stimulation, Implants & Devices: Safe Use & Considerations for MRI |
| Mark Conroy | |
This presentation will describe the MRI related risks to patients with active implantable devices with respect to unintended electrical tissue stimulation. The mechanisms due to RF rectification and gradient induced electrical potential will be described using simplified circuit models. Standard test methods for characterizing device performance in the MRI environment will be described. Finally, risk mitigation strategies and MR Conditional labeling strategies will be reviewed. |
| 16:45 | Adjournment & Meet the Teachers |
Organizers: Jenny Bencardino, Eric Chang, Garry Gold, Emily McWalter, Edwin Oei, Philip Robinson
| S01 | Saturday 15:15 - 16:45 | Moderators: Emily McWalter & Alissa Burge |
| 15:15 | Spine |
| Amelie Lutz | |
Back and neck pain are among the most common reasons to seek medical advice. While there are clearly established guidelines for cross-sectional imaging study utilization in the diagnostic work-up, there has been a significant increase in these exams. But cross-sectional imaging findings have been shown to often poorly correlate with patients’ symptoms. In order to better serve patients, we need new tools to enhance or replace existing MRI methods. In this talk, four potential approaches will be discussed to reach this goal: kinematic MRI, novel sequences to complement existing MRI protocols, MRI around metal in the post-operative setting, and PET/MRI. |
| 15:45 | Bone Marrow MRI: from Reconversion to Infiltration |
| Joan C. Vilanova | |
MRI is the technique of choice to analyze the bone marrow. It is essential to understand the normal composition and distribution of bone marrow and the changes that occur with age, as well as other physiologic factors that can affect those signals. The normal distribution of red and yellow marrow in the skeleton changes with age in a predictable sequence. It is mandatory to understand the standard and advanced techniques such as diffusion and DIXON to perform an accurate evaluation of bone marrow from a physiologic process such as reconversion through an infiltration process. |
| 16:15 | Panel Discussion |
| 16:45 | Adjournment & Meet the Teachers |
Organizers: Kathryn Fowler, Kartik Jhaveri, Lorenzo Mannelli, Valeria Panebianco, Scott Reeder, Reiko Woodhams
| S02 | Saturday 15:15 - 16:45 | Moderators: Kathryn Fowler & Elizabeth Hecht |
| 15:15 | LI-RADS: Pro |
| An Tang | |
The Liver Imaging Reporting And Data System (LI-RADS) was developed to standardize the interpretation, reporting and data collection for imaging examinations in patients at risk for hepatocellular carcinoma (HCC). The system has been developed by committees composed of radiologists, hepatologists, pathologists, and surgeons. In this debate, we will discuss the reasons why LI-RADS is needed and the problems that it solves. In response to current limitations of LI-RADS, we will discuss strategies to address unmet needs and to refine the system in response to new scientific evidence and user feedback. |
| 15:37 | LI-RADS: Con |
| John Leyendecker | |
LI-RADS is an important advance in standardization of HCC imaging and reporting. However, there are still many deficiencies that must be addressed for widespread implementation to succeed. This talk will highlight the concerns of LI-RADS users and the potential ways these concerns can be addressed in the future. |
| 15:59 | PI-RADS: Pro |
| Francois Cornud | |
The PI-RADS scoring system consists in a visual assessment to detect the presence of suspicious foci within the prostate. It has also been developped to describe signs of tumor extraprostatic extension. Diffusion Weighted Imaging (DWI) plays an unvaluable role to achieve this goal. Very high computed b-values allow to visually increase the conspicuity of tumor foci within the peripheral zone (PZ). DWI has also an important role to increase the sensitivity of T2W-MRI to localise tumor foci originating in the transition zone (TZ), without affecting the specificity. Dynamic Contrast Enhanced MRI plays a role to confirm the presence of a tumor in specific areas, like the Anterior FibroMuscular Stroma or to detect signs of seminal vesicle invasion, which may remain undetected by DWI alone. |
| 16:21 | PI-RADS - Con |
| Alberto Vargas | |
This talk will emphasize the weaknesses of the Prostate Imaging Reporting and Data system, highlight areas of potential improvement, and discuss ways of dealing with commonly encountered limitations of the guideline in "real-life" scenarios |
| 16:43 | Adjournment & Meet the Teachers |
Organizers: Qiyong Gong, John Port
| S03 | Saturday 15:15 - 16:45 | Moderators: Qiyong Gong |
| 15:15 | MR of Schizophrenia |
| John Sweeney | |
Schizophrenia is a common, debilitating psychiatric disorder with profound impact on cognitive and social functions. There are several areas in which structural and functional brain imaging are advancing understanding of the pathophysiology of this disorder. Beyond identifying illness associated features, these include: 1) identifying biologically homogeneous subgroups of patients within and across disorders, 2) providing quantitative traits for identifying genetic associations, 3) clarifying how antipsychotic drugs alter brain systems, and 4) characterizing long term progression of illness. This presentation will review progress in each of these areas. |
| 15:45 | MR of Post-Traumatic Stress Disorder |
| Osamu Abe | |
With the advancement not only in magnetic resonance imaging technologies but also sophisticated post-processing techniques and powerful analytical tools, there should be certain CNS differences between PTSD patients and normal control. Hippocampus, amygdala and prefrontal cortex including anterior cingulate cortex are three key structures in the pathophysiology of PTSD, reproducibly confirmed by structural, diffusional, and functional MRI. Furthermore, these structures are related to the impairment both in salience network and default mode network in patients with PTSD. In this talk, we will show the audience recent results for voxel-based analyses and brain connectivity measured by diffusion and functional MRI. |
| 16:15 | Panel Discussion |
| 16:45 | Adjournment & Meet the Teachers |
Organizers: Natalie Serkova, Damian Tyler
| S04 | Saturday 15:15 - 16:45 | Moderators: Natalie Serkova & Damian Tyler |
| 15:15 | CEST MRI: The Technical Aspects |
| Michael McMahon | |
Chemical Exchange Saturation Transfer (CEST) imaging has emerged as an attractive alternative MRI contrast mechanism to T1 and T2 contrast (1-7). This lecture will cover the basic steps in generating CEST contrast maps, including acquisition, B0 map creation, and Post-processing of CEST MRI data. |
| 15:37 | CEST MRI: The Application |
| Kevin Ray | |
During this presentation, I will discuss some of the difficulties of clinical translation of CEST MRI, highlight the similarities and differences between endogenous and exogenous CEST MRI methods, and outline some of the principle applications of these methods in pre-clinical and clinical settings. Examples of such applications include: (1) pH imaging in ischaemic stroke using endogenous amide proton transfer, (2) pH imaging in cancer using exogenous diaCEST and paraCEST agents, (3) endogenous metabolite concentration imaging (e.g. GluCEST, GagCEST, GlycoCEST), and (4) glucose uptake and perfusion imaging using GlucoCEST. |
| 15:59 | Nanoparticle-Based Imaging: The Technical Aspects |
| Kevin Bennett | |
This presentation will outline the physical chemical and physical basis for nanoparticle contrast agent development, modification, and detection for imaging by MRI. Several emerging nanoparticle agents will be discussed in detail. |
| 16:21 | Nanoparticle-Based Imaging: The Application |
| Heike Daldrup-Link | |
This presentation will provide an overview of clinical applications of iron oxide nanoparticles for MR imaging and PET/MR imaging of patients with cancer. This will include safety considerations, applications for whole body cancer staging, applications for monitoring response to cancer immunotherapies and theranostic (combined therapeutic and diagnostic) applications. |
| 16:45 | Adjournment & Meet the Teachers |
| Level 7.4 Rooftop Terrace | Saturday 19:00 - 21:00 | (no CME credit) |
Organizers: Guoying Liu, Elena Vinogradov, Yi-Fen Yen
| N01 | Sunday 8:00 - 9:28 | Moderators: Chrit Moonen & Bruno Madore |
| 8:00 | Introduction: Concurrent MR Imaging of Real-Time Event |
| Bruno Madore | |
The expression 'concurrent MRI' relates to the use of an MR scanner as part of a larger integrated system, as opposed to a standalone diagnostic tool. Examples include image-guided therapies and hybrid imaging, where changes to tissues can be induced and tracked in real time. In this session, the ability of MRI to capture changes caused by ultrasound energy deposition, radiation therapy, brain plasticity and catheter steering will be presented. In the present talk, our work on hybrid ultrasound+MR imaging and on MR-compatible sensor development will also be detailed. |
| 8:30 | MR Imaging of Neuromodulation Feedback |
| Heidi Johansen-Berg | |
The talk will provide examples of use of MRI in humans to monitor effects of neuromodulation (using feedback or brain stimulation). This can be used to provide insights into healthy brain function and also to develop novel interventions for use in neurological or neuropsychiatric disorders. |
| 9:00 | MR Imaging of Therapeutic Ultrasound |
| Chrit Moonen | |
High Intensity Focused Ultrasound (HIFU), similar to External Beam Radiotherapy (EBRT), can be guided by imaging to plan, provide real-time guidance, and evaluate the therapeutic efficacy. MRI has major advantages for guidance because of its superior anatomic detail, and for HIFU for its thermal mapping. Here, we will pay particular attention how MRI can be used to describe and correct displacement of the target area. |
| 9:30 | Break & Meet the Teachers |
Organizers: Edward DiBella, Neville Gai, Vikas Gulani, Ileana Hancu
| N02 | Sunday 8:00 - 9:30 | Moderators: Neville Gai & Ileana Hancu |
| 8:00 | MR Basics (Refresher) Recap of Physics of RF & k-Space Acquisition |
| David Higgins | |
Basic MR physics will be reviewed, to provide a foundation for discussion of more advanced concepts in the course. The mechanism of simple radiofrequency excitation will be shown, and the information content of k-space will be illustrated and discussed. |
| 8:30 | Excitation & Parallel Transmission |
| V. Andrew Stenger | |
This lecture will cover the basic concepts needed to understand the theory and implementation of multi-dimensional RF pulses. The ideas of excitation k-space and the Fourier picture for small tip angle RF pulses will be covered in detail. The common k-space trajectories and pulse designs will be discussed. Examples of 2D and 3D spatially selective excitations as well as spectral spatial pulse designs will be presented. Applications including field inhomogeneity compensation and parallel transmission will be covered as well. |
| 9:00 | Cartesian & Non-Cartesian Sampling Schemes - Advantages & Disadvantages |
| Maria Altbach | |
Cartesian sampling is widely used in conventional MRI, however, non-Cartesian sampling schemes (e.g. radial or spiral sampling) offer advantages over Cartesian schemes. Among them is flexibility and efficiency of k-space sampling, motion insensitivity, and the ability to generate images with high spatio-temporal resolution from limited data. The lecture will cover the basic acquisition schemes of Cartesian and non-Cartesian sampling along with the conventional and state-of-the-art reconstruction methods with an emphasis on advantages and disadvantages. |
| 9:30 | Break & Meet the Teachers |
Organizers: Fernando Calamante, Hanzhang Lu, Steven Sourbron
| N03 | Sunday 8:00 - 9:28 | Moderators: Laura Parkes & Ze Wang |
| 8:00 | Physiology of Perfusion |
| Osamu Togao | |
This presentation covers macro- and micro-anatomy of cerebral vasculature and the basic mechanism and physiology of cerebral perfusion. |
| 8:22 | DSC Acquisition & Reconstruction |
| Ashley Stokes | |
Dynamic susceptibility contrast (DSC) MRI methods provide valuable information regarding cerebral perfusion. In this talk, I will discuss current recommendations for best practices in clinical DSC-MRI acquisition and reconstruction. I will also highlight more recent technological advancements for DSC-MRI, along with the associated advantages and trade-offs of these methods. This talk will provide both a basic foundation for understanding current DSC-MRI protocols and insight into future directions for DSC-MRI acquisition and reconstruction. |
| 8:44 | DSC Post-Processing & Modeling (with Demo) |
| Irene Mikkelsen | |
Pivotal in the understanding of processing of Dynamic Susceptibility Contrast perfusion imaging, is the concept of the Residue Function. This function is the underlying tissue function, which is indepent on how the contrast agent is administered to the tissue. This presentation describes the inverse problem and two ways of solving it. |
| 9:06 | DCE Acquisition & Reconstruction |
| Anders Garpebring | |
This talk will describe the basics of dynamic contrast-enhanced (DCE) MRI with focus on the acquisition of the data. Key prerequisites for accurate quantification of perfusion parameters such as Ktrans are sufficiently high spatial and temporal resolution but also accurate quantification of the contrast agent (CA) concentration. The basics of how this can be achieve will be covered in the talk. |
| 9:28 | Break & Meet the Teachers |
Organizers: Gregor Adriany, Christoph Juchem, Mary McDougall, Greig Scott
| N04 | Sunday 8:00 - 9:30 | Moderators: Natalia Gudino & Michael Twieg |
| 8:00 | Basics of Transmission Lines & Power Transfer |
| Nicola De Zanche | |
This lecture covers the basic concepts of RF power transfer over transmission lines. Tools such as scattering parameters and the Smith chart are also discussed. |
| 8:30 | Volume & Surface Coils |
| Christoph Leussler | |
RF coils (antennas) for MRI are designed to generate a RF magnetic field inside the body. Large body volume coils are optimized for the generation of a homogeneous RF magnetic field. Local surface coils are designed to provide high signal to noise ratio. Different designs and related physical aspects are discussed. |
| 9:00 | Multi-Tuned Coils |
| Dennis Klomp | |
Ever wanted to build your own multi-tuned RF coil to enable metabolic imaging? This 30 minute session will start from scratch and ends with you capable to make the most advanced multi-tuned, transmit and receive coil array (in theory)... |
| 9:30 | Break & Meet the Teachers |
Organizers: James Carr, Tim Leiner
| S01 | Sunday 8:00 - 9:20 | Moderators: Alex Barker & Christopher François |
| 8:00 | Contrast Agents: Practical Use & Safety Aspects |
| Giles Roditi |
| 8:20 | Contrast-Enhanced MRA |
| Jeremy Collins |
| 8:40 | Non-Contrast-Enhanced MRA |
| Ioannis Koktzoglou | |
This presentation will review established and emerging methods for non-contrast-enhanced magnetic resonance angiography. |
| 9:00 | Basics of Flow Imaging Including Extraction of Quantitative Measurements |
| Jos Westenberg | |
Time-of-Flight and Phase-Contrast imaging will be discussed for their role in aniography. Phase contrast imaging is sensitized to flow velocity, affecting the phase signal of flowing spins. This encoding of velocity enables flow velocity quantitation. Quantitative measures derived from velocity encoding will be discussed: valvular flow mapping with regurgitation assessment, transstenotic pressure drop, kinetic energy distribution and wall shear stress. Furthermore, some potential sources of error of phase contrast imaging will be discussed. |
| 9:20 | Break & Meet the Teachers |
Organizers: Anke Henning, Roland Kreis
| S02 | Sunday 8:00 - 9:15 | Moderators: Anke Henning & Roland Kreis |
| 8:00 | UHF MRSI: SNR, Speed & Resolution |
| Michal Považan | |
The temporal and spatial resolution of an MR experiment is always influenced by the available signal-to-noise ratio (SNR). In general, SNR increases with a higher static magnetic field (B0). Magnetic resonance spectroscopic imaging may benefit from the ultra-high field, however novel approaches are necessary to overcome the technical challenges that arise at such high magnetic field strengths. In this talk we focus on the specifics of UHF MRSI and present the most recent MRSI methods where the SNR gain can be traded off for higher spatial or temporal resolution. |
| 8:25 | Undersampled Spectroscopic Imaging: Benefits & Pitfalls |
| Ricardo Otazo | |
This lecture presents the main techniques to undersample MR spectroscopic imaging (MRSI) for increased imaging speed, including parallel imaging, compressed sensing and model-based subspace reconstruction |
| 8:50 | Spectral Editing: MEGA & Beyond |
| Ovidiu Andronesi |
| 9:15 | Break & Meet the Teachers |
Organizers: Christopher Hess, Alex MacKay
| S03 | Sunday 8:00 - 9:50 | Moderators: Christopher Hess & Alex MacKay |
| 8:00 | What Am I Looking for in a New Technique? |
| Scott Reeder | |
Acceptance of a new technique generally requires that the acquisition have one or more of the following qualities: faster, more robust/reliable, improved image quality, or offers new information not previously available by other acquisition techniques. Evaluation of new imaging techniques should focus on the specific anatomy of interest or on a specific clinical question, not the overall appearance of an image. Ultimately, determination of clinical impact requires evaluation of diagnostic accuracy, clinical effectiveness and the impact on clinical decision-making. Effective development and translation of new imaging techniques into clinical care requires partnership with clinical imaging experts. |
| 8:20 | Brain Perspective |
| Ari Blitz |
| 8:40 | Spine Perspective |
| Majda Thurnher |
| 9:00 | Head & Neck Perspective |
| Christine Glastonbury | |
While spatial and contrast resolution has greatly advanced in HN MR imaging and extraordinary detail can be seen with cranial nerve and inner ear imaging, our greatest problem in HN imaging remains the routine neck scan. Obtaining at least two-plane imaging of the neck with T1, T2 FS and T1 post contrast FS sequences is necessary. Diffusion weighted imaging has become an essential component of neck and skull base imaging and should also be included in a HN protocol. Trying to achieve at least 6 sequences in a reasonable time frame is problematic for HN MR imaging, and trying to achieve it with patients who have difficulty with secretion management after chemoradiation is even more complex. |
| 9:20 | What Do I Need to Know to Design a New Technique? |
| Jeffrey Duerk |
| 9:40 | Break & Meet the Teachers |
Organizers: Stephan Maier, Jennifer McNab, Noam Shemesh
| S04 | Sunday 8:00 - 9:30 | Moderators: Dmitry Novikov & Jennifer McNab |
| 8:00 | The Physics of Diffusion: What Are We Measuring? |
| Sune Jespersen | |
This lecture covers the basic physics of diffusion. I cover the random walk as a conceptual model of diffusion as well as a tool for simulations. The relation for the mean square displacement is derived, and scenarios leading to time-dependent diffusivities are described, along with their universal short and long time regimes. A central quantity, the propagator, is introduced, and the diffusion equation describing its evolution derived. Examples of solutions are given, and the cumulant expansion as a general framework to describe diffusion in complex media is presented. The connection to the diffusion MR signal is outlined. |
| 8:22 | Diffusion Encoding Using MRI: Single Pulse, Double Pulse, Oscillating Gradients |
| Andrada Ianus |
| 8:44 | Image Encoding for Diffusion MRI: EPI, Spiral, Radial, Multi-Shot, Etc. |
| Robert Frost | |
Single-shot echo-planar imaging, with parallel imaging and simultaneous multi-slice improvements, remains the most commonly used sequence for diffusion imaging of the brain. Many other sequences have been developed with the goal of increasing the spatial resolution of whole-brain diffusion data and their designs are influenced by several considerations including image artefacts, SNR and efficiency, scan time per image, motion sensitivity, and slice acquisition paradigm. These issues will be discussed and illustrated with examples of recent diffusion sequences. |
| 9:06 | Diffusion MR Signal to Quality Data: Preprocessing & Distortion Correction |
| Stamatios Sotiropoulos | |
In this talk, I will present an overview of the issues we encounter in diffusion MRI data and the preprocessing steps needed prior to starting any data analysis. Geometric distortions due to off-resonance effects, distortions due to subject motion, artifacts from physiological noise, detection of outliers and quality control are some of the topics that will be covered. Correcting for artifacts and distortions is key in order to extract the most from the data and allow subsequent analysis in an unbiased and precise manner. |
| 9:28 | Break & Meet the Teachers |
Organizers: Guoying Liu, Elena Vinogradov, Yi-Fen Yen
| N01 | Sunday 10:00 - 11:30 | Moderators: Bruno Madore & Chrit Moonen |
| 10:00 | Image-Guided Interventional Stroke Treatment: State of the Art and Future Directions |
| Steven Hetts | |
Periprocedural and intraprocedural imaging for acute ischemic stroke treatment are evolving rapidly. We will discuss the current imaging approach and evolving trends in imaging during stroke treatment. |
| 10:30 | MR Imaging of Drug & Gene Delivery & Therapeutic Effects |
| Kullervo Hynynen |
| 11:00 | MRI-guided Radiation Therapy |
| Cornelis van den Berg | |
This educational discusses the use of MRI in radiation therapy with a focus on MRI-guided radiation therapy. It explains the technological development in relation to how this disruptive technology can change radiation therapy improving outcome and patient toxicity. |
| 11:30 | Panel Discussion |
| 12:00 | Adjournment & Meet the Teachers |
Organizers: Edward DiBella, Neville Gai, Vikas Gulani, Ileana Hancu
| N02 | Sunday 10:00 - 11:30 | Moderators: Neville Gai & Ileana Hancu |
| 10:00 | Flow & Velocity Imaging |
| Martin Graves | |
The standard method of quantifying cardiovascular velocity and flow in MRI is to use a phase contrast (PC) imaging technique. This presentation will describe the basic principles of the PC method, its practical implementation and clinical optimisation. |
| 10:30 | Motion Compensation: Pulse Sequence & Reconstruction Strategies |
| Pelin Aksit Ciris | |
MRI is slow relative to the time scale of patient motion. Fundamentals of spin physics restrict scan times for most applications to the order of several seconds to minutes. Demand for higher resolution isotropic volumes has further increased acquisition times for some scans. Motion over the course of an MR acquisition has the potential to corrupt imaging data. This talk will describe potential sources of motion and their impact on MR data, then review conventional and emerging strategies for pulse sequence and reconstruction strategies for motion compensation. Advantages and disadvantages of various methods will be discussed. |
| 11:00 | Reduced FOV, Reference Scans, Gradient Pre-Emphasis |
| Xiaohong Joe Zhou | |
This lecture focuses on three pulse sequence strategies to improve the image quality. First, methods for reducing the field-of-view (FOV) are described using examples of spatial saturation, multiple one-dimensional selective RF pulses, and/or multi-dimensional RF excitation. Second, reference scans are presented for measuring errors in k-space and enabling various phase corrections in pulse sequences utilizing echo trains. Third, gradient pre-emphasis is discussed as an effective method to reduce the adverse effects caused by eddy currents. Although these three topics may appear isolated, together they reflect a central theme of how to improve image quality by managing the artifacts. |
| 11:30 | Lunch & Meet the Teachers |
Organizers: Fernando Calamante, Hanzhang Lu, Steven Sourbron
| N03 | Sunday 10:00 - 11:30 | Moderators: Laura Parkes & Ze Wang |
| 10:00 | DCE Post-Processing & Modeling (with Demo) |
| Jesper Kallehauge | |
Post-processing and modeling of DCE time curves allow for reducing a vast amount of data into a set of parametric maps related to the underlying tissue properties: Permeability, Perfusion, compartmental composition etc. Multiple steps and methods are involved in reaching this point with possible pitfalls resulting in potential misinterpretation of the acquired data. Participants should come away from this seminar understanding these steps and how choices made during data acquisition influence what can sensibly be extracted from the data. |
| 10:22 | ASL Acquisition & Reconstruction |
| Weiying Dai | |
The lecture will cover the key components of arterial spin labeling (ASL) data acquisition and reconstruction, including basic principles, different labeling approaches, background suppression techniques to improve the temporal stability of ASL signals, advanced ASL techniques, readout options, and image reconstruction. |
| 10:44 | ASL Post-Processing & Modeling (with Demo) |
| Michael Chappell | |
The aim of this talk is to introduce the key steps involved in the analysis of ASL data to produce a perfusion-weighted image, a full quantified perfusion image and even images of other haemodynamic parameters. We will see that ASL analysis is for the most part quite simple and eve more advance methods are quite accessible through software tools that are now freely available. |
| 11:06 | ASL: Beyond CBF |
| Peiying Liu | |
This talk will cover advanced ASL-based techniques which provide quantitative measurements of hemodynamic and physiological parameters beyond brain perfusion measured in conventional ASL. Such advances include the implementation of different preparation and acquisitions modules, as well as comprehensive modeling of the signals. With these techniques, new hemodynamic and physiological parameters, including blood oxygenation, tissue transit time, arterial blood volume, vascular compliance, and water permeability of blood-brain barrier, can be obtained. |
| 11:28 | Adjournment & Meet the Teachers |
Organizers: Gregor Adriany, Christoph Juchem, Mary McDougall, Greig Scott
| N04 | Sunday 10:00 - 11:30 | Moderators: Natalia Gudino & Michael Twieg |
| 10:00 | Receive Arrays & Circuity |
| Peter Roemer | |
Fundamental limits of Signal-to-Noise(SNR) ratio exist that cannot be exceeded even with an idealized noiseless receiver coil. These limits can be approached in certain circumstances with proper coil design. The objective is to provide the audience with an understanding of these limits and their relationship to practical aspects of coil design. In turn this will help guide the choice of coil element size, array extent, and total coil count for imaging a specific anatomical location. |
| 10:30 | Transmit Arrays & Circuitry for UHF Body Imaging |
| Stephan Orzada | |
As the main magnetic field strength increases, the corresponding RF wavelength is shortened. This leads to pronounced wave effects in the transmit field, causing inhomogeneous excitation. Multi-channel arrays provide additional degrees of freedom to mitigate such effects and to manipulate (or to tailor) RF transmission. Roughly these can be divided in 3 types, namely local arrays, remote circumferential arrays and travelling wave arrays. Examples of these arrays are presented in this educational talk. |
| 11:00 | RF Modelling |
| Joseph Rispoli | |
Radiofrequency (RF) modelling offers an efficient means to characterize the design and performance of RF coils. Simulations are particularly important for establishing MRI scan parameters to ensure safety compliance. This talk provides an overview of several numerical methods that may be employed to model the electrodynamics of RF coils; emphasis is placed on the finite-difference time-domain (FDTD) method and considerations for achieving accurate simulation and validation. |
| 11:30 | Lunch & Meet the Teachers |
Organizers: James Carr, Tim Leiner
| S01 | Sunday 10:00 - 11:40 | Moderators: Alex Barker & Christopher François |
| 10:00 | Advanced Techniques: 4D Flow, TKE |
| Pim van Ooij | |
The first part of the talk will show the derivation of clinically relevant parameters (velocity vectors, peak velcocity, wall shear stress) from 4D flow MRI data in laminar flow conditions. the second part of the talk will show the derivation of clinically relevant parameters (turbulent kinetic energy, turbulent wall shear stress) from 4D flow MRI data in turbulent flow conditions. |
| 10:20 | MR Techniques for stroke-related vessel wall imaging |
| Zhaoyang Fan | |
Stroke is one of the major causes of morbidity and mortality worldwide and is the number one cause of adult disability. This disease primarily arises from pathogenesis in a large blood vessel such as the aorta, carotid artery, and intracranial artery and venous sinus. Black-blood MR, commonly known as MR vessel wall imaging (VWI), has emerged as a leading noninvasive imaging modality for directly assessing the vessel wall. Many of previous studies have shown the promise of using MR VWI for characterizing different vessel wall pathologies that potentially result in a stroke. The present lecture will focus on recent (within the last decade) technical developments in MR VWI at the carotid artery, intracranial vessels, and aortic arteries. |
| 10:40 | Cerebrovascular Vessel Wall Imaging from a Clinical Perspective |
| Anja van der Kolk | |
Vessel wall MRI of the supra-aortic and intracranial vasculature has seen an exponential increase in popularity in the last two decades. It can provide a wealth of information on pathologic processes of the vessel wall associated with cerebrovascular diseases – like atherosclerosis, vasculitis, Moyamoya disease and aneurysms – that may be used in the differential diagnosis of vasculopathies, in (stroke) risk assessment, and for planning individual patient-based treatment strategies. This lecture will discuss the clinical potential of vessel wall MRI in these cerebrovascular diseases, with a specific focus on intracranial vessel wall pathology. |
| 11:00 | Chest & Abdominal |
| Iacopo Carbone | |
Cardiovascular MRI: Vascular: Part 2
The target audience of this lecture will be imagers (radiologists or cardiologists), dealing with vascular examinations on regular daily practice. Training doctors will particularly benefit from this lecture. The presentation will give the basis on how to perform Vascular MRI study of the aorta.The main focus of the presentation will be the acute aortic syndromes, encompassing the whole spectrum of the topic from its pathophysiology and revised classification to different MRI protocols and diagnosis. At the end of the presentation the audience will be able to recognize and classify the main acute aortic clinical scenarios, differentiating real emergencies from deferrable urgencies and to eventually integrate imaging techniques including CT and echocardiography. |
| 11:20 | Peripheral Vascular Disease |
| Jeremy Collins |
| 11:40 | Adjournment & Meet the Teachers |
Organizers: Anke Henning, Roland Kreis
| S02 | Sunday 10:00 - 11:40 | Moderators: Anke Henning & Roland Kreis |
| 10:00 | Spectral Simulations in GAMMA: Gradients & Soft Pulses |
| Jan Willem van der Veen | |
Gradients and soft pulses are simulated in GAMMA to correct for technical shortcomings of actual mrs sequences. Simulations are made in a spatial grid to handle chemical shift artifacts, four compartment problem, and the effect of crushers. Described is how to prevent aliasing of the grid with the phase roll of the crushers and how to speed up the calculations. Finally a few practical applications are mentioned to improve quantification of the metabolites. |
| 10:25 | Classification Tools for MRS of Cancer |
| Sabine Van Huffel | |
This lecture explains how to extract diagnostic information from the raw MR spectra possibly combined with information from other MR modalities. Starting from basic and advanced concepts in machine learning, the most important classification methods are surveyed. The application of these classifiers in assessing brain tumor heterogeneity is illustrated in a variety of case studies. In-vivo single-voxel MR Spectroscopy (MRS) as well as chemical Shift Imaging are considered, long-echo time as well as short-echo time acquisition schemes. Moreover, it is shown how to combine these measurements with other basic (T1-weighted,T2-weighted) as well as advanced (PWI, DWI, DTI, DKI) MR modalities. |
| 10:50 | Functional MR Spectroscopy |
| Paul Mullins | |
Proton MRS is often thought of as a static measure. In the past 10 years however, this view has been challenged by several studies showing that it is actually sensitive to fluctuations in neurometabiolites as a result of neural activity. This technique of "functional" MRS (fMRS) is not new, having been around since 1991, however with the ready availability of 3T or higher MRI systems, improved acquisition techniques and accurate fitting packages, fMRS has seen renewed interest. A discussion of the main technique, the result that might be expected and experimental considerations for fMRS will be presented using Glutamate as the model neurometabolite. Attendees should come away with a renewed appreciation for the role 1H-fMRS may play in understanding neural activity and function. |
| 11:15 | Diffusion-weighted MR Spectroscopy |
| Francesca Branzoli | |
Diffusion-weighted 1H MR spectroscopy (DW-MRS) provides unique cell-specific and compartment-specific microstructural information based on the diffusion properties of intracellular metabolites in brain tissue. In this talk, the basic aspects of DW-MRS data acquisition and processing will be presented, together with some clinical and preclinical applications. |
| 11:15 | Adjournment & Meet the Teachers |
Organizers: Stephan Maier, Jennifer McNab, Noam Shemesh
| S04 | Sunday 10:00 - 11:30 | Moderators: Chun-Hung Yeh & Jennifer McNab |
| 10:00 | Diffusion Data Interpretation: Data-Driven |
| Jürgen Finsterbusch | |
The signal of diffusion-weighted MR reflects the tissue structure on a cellular or microstructure scale. Many different approaches have been proposed that aim to characterize diffusion-weighted data or derive diffusion or microstructural tissue properties from it. They could be divided into model- and data-driven approaches. Data-driven approaches either derive diffusion or structural properties directly from the data or, in a broader sense, approximate the data with equations that are “borrowed” from diffusion in simple physical systems or motivated mathematically. The most important of these approaches will be covered in this presentation. |
| 10:22 | Diffusion Data Interpretation: Model-Driven |
| Ariel Rokem | |
Models of diffusion MRI are mathematical expressions that describe the data, summarize it and approximate it. The values of the fit parameters are used to interpret the data in light of the structure of the tissue or its physical properties. This presentation will introduce a framework for model comparison using cross-validation: the model is fit to one part of the data and the model parameters are used to predict the signal in another part of the data. Cross-validation is used to assess parameter reliability, as well as accuracy of the model with respect to the data. |
| 10:44 | Tractography |
| Thijs Dhollander | |
In this introductory course on diffusion MRI based tractography, I will introduce the basics of tractography. I will by no means provide a comprehensive overview or review of all possible techniques and literature, but rather focus on the most essential basics of this area and a selection of its applications. As a result of attending this course, participants should be empowered to participate in the ongoing discussions about the strengths and limitations of tractography, as well as make informed and critical decisions on the use of tractography in their own work. |
| 11:06 | Microstructure for In-Vivo Human Applications |
| Susie Huang | |
This lecture will provide a brief overview of technical considerations involved in in vivo diffusion MR microstructural imaging studies with a focus on human neuroimaging. We will cover biophysical models and signal representations of the diffusion MRI signal as they relate to probing tissue microstructure in the human brain. We will study metrics derived using different diffusion models and acquisition schemes in the setting of normal development and pathological changes in white matter disease. In addition, the specific advantages of high-gradient systems for characterizing tissue microstructure for in vivo human imaging will be explored. |
| 11:28 | Adjournment & Meet the Teachers |
Organizers: Christopher Hess, Alex MacKay
| S03 | Sunday 10:10 - 12:00 | Moderators: Christopher Hess & Alex MacKay |
| 10:10 | Fast Imaging - Parallel Imaging, Compressed Sensing & Beyond |
| John Pauly | |
Throughout the history of MRI a long sequences of techniques have been developed to make images with less data. When MRI first emerged as a clinical imaging modality, images were acquired by fully sampling a rectangular region in spatial-frequency, or k-space. Faster acquisitions have been based on the structure of the data, knowledge of the receive array sensitivity, models of the statistics of the image, and, more recently, models of the images themselves. The common thread is using other knowledge we have about the MRI system and subject to provide additional prior information to reduce the amount of data we need to collect. This talk will highlight this sequence of methods, and look at the potential and challenges they present for clinical application. |
| 10:32 | Modern Functional & Diffusion Imaging |
| Mara Cercignani | |
Diffusion and functional MRI are among the most popular MRI techniques used in neuroscience research. Although basic versions of these techniques have found their way to the clinic relatively soon after their introduction, almost none of the technological advances introduced in the past 20 years have been adopted outside the research setting. This lecture will review some of the latest flavours of diffusion and functional MRI and their potential clinical applications |
| 10:54 | Fingerprinting & Synthetic MRI |
| Nicole Seiberlich |
| 11:16 | MRS of Novel Metabolites |
| Gulin Oz | |
This talk will start with an overview of neurochemicals (beyond NAA, Cr, Cho) measurable by MRS and the cellular/biochemical processes that they reflect, present examples of their utility in addressing novel biological questions, then follow with data quality requirements to be able to reliably quantify these neurochemical profiles and finish with a summary of recent efforts to simplify and automate acquisition of high quality MRS data at 3T and make advanced MRS acquisitions MR technologist friendly. |
| 11:38 | Panel Discussion |
| 12:00 | Adjournment & Meet the Teachers |
Organizers: Chunlei Liu, Peter van Zijl, Elena Vinogradov
| N01 | Sunday 13:15 - 14:45 | Moderators: Jongho Lee & Elena Vinogradov |
| 13:15 | Paramagnetic & Diamagnetic Susceptibility in Tissue |
| Ferdinand Schweser | |
This class will discuss the chemistry and physics of magnetic susceptibility, explaining why some substances affect tissue susceptibility substantially when they are present in very low concentrations whereas other substances need to be present in high concentrations to alter the tissue’s susceptibility measurably. We will discuss the how and why of the differential effects of magnetic susceptibility on |
| 13:37 | Magnetization Transfer: MTC, NOE, CEST |
| Alexej Jerschow | |
The aim of this presentation is to give the MRI practitioner a good overview of the methods used in CEST and MT imaging, the underlying mechanisms, the current state of the art, and to outline the opportunities and limitations of the methods. |
| 13:59 | Tissue Magnetic Susceptibility Mapping (QSM) |
| Barbara Dymerska |
| 14:21 | What Are We Really Measuring in CEST? |
| Daniel Gochberg | |
This talk will examine the underlying drivers of the CEST signal, and it will discuss the implications for choosing CEST pulse sequences and metrics that maximize solute specificity. |
| 14:43 | Break & Meet the Teachers |
Organizers: Edward DiBella, Neville Gai, Vikas Gulani, Ileana Hancu
| N02 | Sunday 13:15 - 14:35 | Moderators: Jeffrey Fessler & Berkin Bilgic |
| 13:15 | Parallel Imaging |
| Suchandrima Banerjee | |
With the increasing use of multicoil array for MR signal reception, and motivated by the need to increase acquisition speed, parallel imaging has become as essential part of MR scans. This talk will aim to impart basic understanding and develop an intuition for underlying concepts of parallel imaging reconstruction with a focus on most widely used methods such as SENSE and GRAPPA. Dynamic acceleration and extension to non-cartesian trajectories will be touched upon and the impact of parallel imaging reconstruction on signal-to-noise will be discussed. |
| 13:35 | Basic Sparsity & Compressed Sensing |
| Michael Lustig | |
T.B.A. |
| 13:55 | Low-Rank Methods |
| Bradley Sutton | |
For dynamic imaging or parameter mapping applications, there is a significant amount of spatiotemporal correlations in the data, with many parts of the image sharing similar temporal signal profiles. This results in a data matrix that is low rank. Several methods have been developed to exploit this low-rank structure to achieve very high imaging speed. This talk will describe these low rank methods and demonstrate the imaging speed that can be achieved. |
| 14:15 | Dictionary & Model-Based Methods |
| Mariya Doneva | |
This lecture explains the principles of model-based reconstruction methods and their linearization using dictionaries for MR parameter mapping. |
| 14:35 | Break & Meet the Teachers |
Organizers: Fernando Calamante, Hanzhang Lu, Steven Sourbron
| N03 | Sunday 13:15 - 14:55 | Moderators: Laura Parkes & Thomas Christen |
| 13:15 | Novel Labeling Techniques of ASL |
| Qin Qin | |
This lecture will describe in depth the most recent developments of ASL labeling techniques. PCASL has been further optimized to minimize sensitivity to off-resonance and pulsatile velocity at the labeling plane. Multi-delay PCASL aims to reduce the effect of prolonged transit time. In addition to the improvements of spatially selective ASL, advanced velocity-selective pulse trains have been proposed, for more robustness to eddy current effects, or higher perfusion signal with Fourier transform based velocity selective inversion. Acceleration-selective ASL has also been demonstrated. The pros and cons of each labeling method will be compared. |
| 13:40 | Technical Advances in Body ASL |
| Charlotte Buchanan | |
There have been a number of recent advances in body ASL. ASL has been applied in the heart, liver, kidney and placenta with studies using ASL in diseases such as diabetes, compensated liver cirrhosis and chronic kidney disease. There are however a number of considerations that are required for use of ASL in the body including which labelling and readout schemes to use and how to deal with respiratory and cardiac motion. Efforts are now needed to harmonise techniques and assess variation in sensitivity, specificity and reproducibility in order to make ASL a clinically useable tool for body applications. |
| 14:05 | Is ASL Useful for Brain Mapping? |
| Wen-Chau Wu | |
Since its introduction in 1990's, ASL has gone through abundant developments that have remarkably improved this contrast-material-free technique in data acquisition, image quality, and quantitative modeling. We now have a variety of methods to choose from and a number of review articles to refer to. However, it still seems an open question when it comes to the usefulness of ASL in brain mapping. In this presentation, the issues that have been keeping us from saying yes to the question will be reviewed. The usefulness and caveats of ASL in brain mapping will be discussed from the viewpoint of clinical application. |
| 14:30 | DCE/DSC Beyond Perfusion & Permeability |
| Ben Dickie | |
A healthy cerebrovasculature is crucial for meeting the brains ever changing demand for oxygen and nutrients. Aging and many neurodegenerative diseases lead to insidious vascular changes to vessel size, geometry, and blood brain barrier (BBB) integrity. New approaches to the acquisition and analysis of DCE- and DSC-MRI data are providing novel insights into these cerebrovascular abnormalities, aiding understanding of disease mechanisms and helping to identify novel treatment targets. |
| 14:55 | Break & Meet the Teachers |
Organizers: Gregor Adriany, Christoph Juchem, Mary McDougall, Greig Scott
| N04 | Sunday 13:15 - 14:25 | Moderators: Natalia Gudino & Michael Twieg |
| 13:15 | Dielectric Materials & Resonators |
| Rita Schmidt | |
This talk will review and explain effects in dielectric materials relevant to MRI. It will cover effects due to the body tissues properties, tailoring of the RF field using high permittivity dielectric materials as well as resonant structure implementations. Applications of dielectrics for MRI in a range of magnetic fields will be shown. |
| 13:50 | UHF Coil & Array Design |
| Tamer Ibrahim | |
The clinical and research potential of MRI for whole-body applications at high (≥ 3 tesla) fields and of head applications at ultrahigh (UHF) (≥7 tesla) fields appears to be limitless. It is however limited by technical challenges. The most notable of these difficulties include 1) safety concerns regarding exceeding radiofrequency (RF) power deposition in tissue and 2) large image inhomogeneity/voids due to “undesired” RF field inhomogeneity across the anatomy. The main aim of this course is to explore UHF coil and array designs that aim at addressing these issues. |
| 14:25 | Break & Meet the Teachers |
Organizers: Sebastian Kozerke, Reza Nezafat, Bernd Wintersperger
| S01 | Sunday 13:15 - 14:35 | Moderators: Aleksandra Radjenovic & Peng Hu |
| 13:15 | Cardiac Function |
| Pierre Croisille |
| 13:35 | Myocardial Perfusion |
| Raymond Kwong |
| 13:55 | Scar Imaging |
| Charlene Liew | |
Scar imaging is the backbone of viability quantification of |
| 14:15 | Clinical Needs & Applications |
| David Sosnovik |
| 14:35 | Break & Meet the Teachers |
Organizers: Kathryn Fowler, Catherine Hines, Kartik Jhaveri, Lorenzo Mannelli, Valeria Panebianco, Scott Reeder, Reiko Woodhams
| S02 | Sunday 13:15 - 14:45 | Moderators: Masoom Haider & David Karow |
| 13:15 | Technical Considerations for Prostate MRI Acquisition |
| Alberto Vargas | |
The aim of this session is to summarize the latest technical developments relevant to optimization of clinical prostate MRI protocols |
| 13:37 | Guidelines & Recommendations |
| Jelle Barentsz | |
In this talk, a literature review will be shown of PI-RADS v2. The role of experience and training will be discussed. To ensure optimal quality, certification and quality criteria will be provided. Finally, the role of an expertise network will be emphasized. It will be concluded, that it has been shown that PI-RADSv2 is an adequate ‘‘language’’ for assessing the risk of the presence of clinically significant PCa. The sensitivity is significantly better than that of PI-RADSv1. Nonetheless, there is large heterogeneity that could be reduced by an improved PI-RADSv3 and by training and certification of radiologists. Equally important, however, is the training of urologists and other involved physicians in being able to communicate in the same ‘‘language’’. |
| 13:59 | Prostate MRI & Recurrence |
| Jurgen Fütterer | |
mpMRI is a helpful tool in the evaluation of the treated prostate gland. |
| 14:21 | PET/MRI of Prostate Cancer |
| Joseph Ippolito | |
This educational talk provides an overview of PET/MRI in the evaluation of prostate cancer with a focus on the strengths and weaknesses of PET/MRI versus PET/CT as well as the individual strengths and weaknesses of MRI versus PET. This talk also discusses methods for evaluating initial staging as well as biochemical recurrence in prostate cancer patients and discusses current progress made in the radiopharmaceutical field and its ability to synergize with emerging methods in MRI. |
| 14:43 | Break & Meet the Teachers |
Organizers: Fernando Boada, Elna-Marie Larsson
| S03 | Sunday 13:15 - 14:45 | Moderators: Fernando Boada & Elna-Marie Larsson |
| 13:15 | MR/PET Methodology Brain (Advantages & Limitations) |
| Julie Price |
| 13:45 | Attenuation Correction with MR/PET |
| Hongyu An | |
PET/MR is a promising multi-modality imaging approach. Attenuation is by far the largest correction required for quantitative PET imaging. The challenges in MR based PET attenuation correction have negatively impacted the acceptance of PET/MR in clinical trials. Since the inception of PET/MR, MR based attenuation correction approaches have been extensively pursued, especially for brain imaging. In this presentation, I will provide background of PET/MR attenuation correction and review various methods. The advantages and disadvantages of these methods are discussed. |
| 14:15 | Hybrid PET/MR in Epilepsy |
| Jie Lu |
| 14:45 | Break & Meet the Teachers |
Organizers: Stephan Maier, Jennifer McNab, Noam Shemesh
| S04 | Sunday 13:15 - 14:30 | Moderators: Jennifer McNab & Noam Shemesh |
| 13:15 | Tissue Architecture & Water Diffusion Obstacles |
| Itamar Ronen |
| 13:40 | Spatial & Temporal Features of Diffusion Encoding |
| Frederik Laun | |
Links between measured signal, the temporal profile of the diffusion-encoding gradients and spatial features of the measured probes will be explained. Among others, the temporal gradient profiles "short-short", "long-long", "long-short", and gradient profiles with multiple gradient pulses will be discussed. |
| 14:05 | Looking from Within: Diffusion of Compartment Specific Metabolites |
| Julien Valette | |
Diffusion-weighted NMR spectroscopy (DW-MRS) offers the unique ability to non-invasively quantify diffusion properties of endogenous brain metabolites in vivo. In contrast to water molecules, which are ubiquitous in biological tissues, most brain metabolites are confined into the intracellular space, and some of them are even thought to exhibit preferential cellular compartmentation (within neurons or glial cells). It is thus expected that DW-MRS may provide specific cellular information. Here we will see how DW-MRS can be related to cellular microstructure, opening perspectives for non-invasive and quantitative measurements of cell-specific morphology under normal and pathological conditions. |
| 14:30 | Break & Meet the Teachers |
Organizers: Chunlei Liu, Peter van Zijl, Elena Vinogradov
| N01 | Sunday 15:15 - 16:43 | Moderators: Jongho Lee & Elena Vinogradov |
| 15:15 | Susceptibility Anisotropy |
| Richard Bowtell |
| 15:37 | CEST MRI of Biomolecules |
| Kannie WY Chan | |
Chemical Exchange Saturation Transfer (CEST) MRI allows us to access molecular information with an enhanced sensitivity. Various contributing proton exchange mechanisms provide ample information for imaging biomolecules and their related pathophysiology. This molecular contrast is sensitive to alterations of exchanging environments in vivo, e.g. CEST contrast of proteins in the brain is different from that in brain tumors with acidic pH. Thus, CEST contrast characterized by the z-spectrum provides readouts for comprehensive physiological and molecular assessments. This talk will present CEST imaging of biomolecules in the brain, and its applications, challenges and opportunities in studying brain tumors and neurological disorders. |
| 15:59 | QSM Clinical Applications |
| Yukunori Korogi | |
The QSM values of the substantia nigra were significantly higher in PD patients than in healthy subjects. QSM showed higher diagnostic performance than R2* mapping for the discrimination between PD patients and controls. The QSM value in GPl increases gradually with age, which allows for the identification of GPm in elderly PD subjects. QSM can detect the abnormalities in normal-appearing basal ganglia in patients with neuropsychiatric systemic lupus erythematosus (NPSLE), which likely represents increased iron deposition. |
| 16:21 | CEST Almost Clinical Applications |
| Seth Smith | |
The goal of this educational presentation is to discuss the important contributions that CEST MRI can have for clinical-translational studies, by highlighting the unique contrasts available and examining the current applications of CEST MRI in the literature. We will further discuss the potential limitations for more clinically viable adoption of CEST and discuss the opportunities to overcome these limitations, including some studies that have begun to take the clinical leap. We will close by discussing the potential impact of a unique contrast to clinical-translational studies of the human condition. |
| 16:43 | Adjournment & Meet the Teachers |
Organizers: Edward DiBella, Neville Gai, Vikas Gulani, Ileana Hancu
| N02 | Sunday 15:15 - 16:55 | Moderators: Berkin Bilgic & Jeffrey Fessler |
| 15:15 | MR Fingerprinting: Introduction |
| Martijn Cloos | |
Magnetic Resonance Fingerprinting (MRF) is an exciting new framework to rapidly acquire simultaneous quantification of multiple tissue properties, but what is it that distinguishes MRF from other quantitative MR techniques? |
| 15:35 | MR Fingerprinting: Reconstruction Considerations |
| Debra McGivney | |
This lecture will outline various considerations associated with the quantification of tissue properties in the framework of MR fingerprinting |
| 15:55 | Machine Learning: Introduction |
| Martin Uecker | |
Machine learning has been a hot topic lately due to the substantial advances in classification, image segmentation and many other tasks where the best-performing methods are now often based on deep neural networks. Machine learning can be applied even when a mathematical description of the model is not at hand or too complicated. This talk will give a brief introduction to machine learning with a focus on artificial neural networks. |
| 16:15 | Machine Learning: Practical Approaches to Reconstruction |
| Mehmet Akçakaya | |
Machine learning methods have found wide use in MRI reconstruction, with a recent focus on artificial neural networks, in particular convolutional neural networks. In this talk, we will overview both model-based and data-driven machine learning approaches for reconstruction. We will also consider practical aspects of implementing deep artificial neural networks for MRI reconstruction. |
| 16:35 | Alternate Reconstruction Workflows: Practical Experience |
| Craig Meyer | |
This educational talk will discuss image reconstruction software platforms that go beyond the platforms provided by the vendors. These platforms can be used for prototyping new reconstruction methods and for enabling capabilities such as real-time interactive scanning. Open-source image reconstruction software libraries accelerate image reconstruction research and enable reproducible research. |
| 16:55 | Adjournment & Meet the Teachers |
Organizers: Fernando Calamante, Hanzhang Lu, Steven Sourbron
| N03 | Sunday 15:15 - 16:30 | Moderators: Thomas Christen & Laura Parkes |
| 15:15 | Advanced Reconstruction Techniques for DCE/DSC |
| Krishna Nayak | |
This talk will review advanced reconstruction methods for DCE-MRI and DSC-MRI. These methods allow for superior extraction of perfusion, permeability, and other tracer-kinetic parameters of interest (from noisy data), and allow for improvements in spatio-temporal resolution and coverage through the use of sparse data sampling (in k,t space). We will start by reviewing the current workflow in DCE/DSC, and identifying the opportunity for improvement. Then we will go through four classes of reconstruction, which have some overlap: 1) spatial and temporal sparsity constraints, 2) data-driven constraints, 3) tracer-kinetic model-based constraints, 4) arterial input function estimation. Finally, we will discuss the magnitude of the improvement that can be achieved using these techniques. |
| 15:40 | Methods to Validate Quantitative Perfusion Measures |
| Audrey Fan | |
Cerebral blood flow (CBF) is a critical physiological biomarker that select appropriate treatments for cerebrovascular patients and is affected in aging and numerous neurological disorders. However, validation of perfusion biomarkers has been challenging, due to (a) inability to compare with a simultaneous reference standard; and (b) insufficient testing in disease cases, where pathology may interact with the imaging mechanism itself to create CBF inaccuracies. This talk describes how to define an appropriate perfusion measure to address a research/clinical question, and design experiments to validate this measurement. It also describes multi-modal imaging and challenge studies (cerebrovascular reactivity) contribute confidence in quantitative perfusion measures. |
| 16:05 | New Contrast Agent/Tracer in Perfusion Imaging? |
| Thomas Christen | |
The vast majority of perfusion MR approaches require the injection of a gadolinium based contrast agent or the magnetic labeling of arterial spins. Yet, other types of contrasts or tracers have also been proposed to probe the micro or macro vascular network. This lecture will present recent perfusion techniques based on the use of (1) iron oxide particles, (2) spontaneous or challenge-based BOLD contrast fluctuations, and (3) hyperpolarized compounds. These methods can offer high SNR, short acquisition times, and provide access to new biophysical markers such as microvessel geometry, hematocrit and blood oxygenation. |
| 16:30 | Adjournment & Meet the Teachers |
Organizers: Gregor Adriany, Christoph Juchem, Mary McDougall, Greig Scott
| N04 | Sunday 15:15 - 16:15 | Moderators: Natalia Gudino & Michael Twieg |
| 15:15 | Construction of Rx Arrays |
| Robin Etzel | |
The main aim of this course is to demonstrate MRI researchers/students the basic procedures for phased-array construction and show an optimized protocol for constructing, tuning and decoupling a highly parallel array coil. The goal is to provide a better understanding of the basic experimental RF tools and procedures to facilitate the efficient design and construction of highly parallel MRI receive-arrays. We demonstrate the protocol with the construction of a 16-channel coil array of overlapped surface coil elements. |
| 15:45 | Construction of Rx Arrays |
| Robin Etzel | |
The main aim of this course is to demonstrate MRI researchers/students the basic procedures for phased-array construction and show an optimized protocol for constructing, tuning and decoupling a highly parallel array coil. The goal is to provide a better understanding of the basic experimental RF tools and procedures to facilitate the efficient design and construction of highly parallel MRI receive-arrays. We demonstrate the protocol with the construction of a 16-channel coil array of overlapped surface coil elements. |
| 16:15 | Adjournment & Meet the Teachers |
Organizers: Sebastian Kozerke, Reza Nezafat, Bernd Wintersperger
| S01 | Sunday 15:15 - 16:55 | Moderators: Aleksandra Radjenovic & Elie Mousseaux |
| 15:15 | Myocardial Strain Assessment: Techniques & Processing |
| El-Sayed Ibrahim | |
Different MRI techniques have been developed over the past 30 years for measuring heart mechanics and assessing regional cardiac function. These techniques include tagging with saturation bands, spatial modulation of magnetization (SPAMM), complementary SPAMM (CSPAMM)), harmonic-phase (HARP) analysis, strain-encoding (SENC), displacement-encoding with stimulated-echoes (DENSE), tissue phase-mapping (TPM), cine cardiac feature-tracking (FT), and magnetic resonance elastography (MRE). Further, the recent advancements in in vivo MRI diffusion tensor imaging (DTI) of the heart allowed for better understanding of the cardiac myofiber structure and its effect on the heart function. In this presentation, these techniques will be reviewed along with their clinical applications. |
| 15:35 | Cardiac DTI: Techniques & Postprocessing |
| Andrew Scott | |
Diffusion tensor cardiovascular magnetic resonance is unique in noninvasively assessing cardiac microstructure. In this session we examine the acquisition and processing techniques used to overcome the difficulties in measuring microscopic diffusion while the heart is moving with the cardiac and respiratory cycles. |
| 15:55 | Clinical Needs & Applications |
| Andrew Taylor | |
Cardiac magnetic resonance (CMR) Imaging is now an essential investigation in the management algorithm of many cardiac conditions. By providing highly accurate structural and functional information, as well as non-invasive tissue characterization, CMR can improve both diagnostic accuracy and quantification of disease severity, leading to more effective healthcare delivery. Evolving CMR techniques, such as those utilizing parametric mapping and 4-dimensional flow quantification, offer new mechanistic insights into disease processes and may ultimately drive the development of novel targets for intervention. |
| 16:15 | T1/T1rho/MT Imaging: Principles & Techniques |
| Walter Witschey |
| 16:35 | T2/T2* Imaging: Principles & Techniques |
| Rohan Dharmakumar | |
This presentation will aim to achieve three tasks: a) outline key cardiac MRI approaches used for T2 and T2* imaging;(b) describe the recent advances in T2 and T2* imaging; and (c) summarize the evolving T2- and T2*-based cardiac MRI-based biomarkers that are being actively studied for improving the clinical management of heart disease. |
| 16:55 | Adjournment & Meet the Teachers |
Organizers: Kathryn Fowler, Catherine Hines, Kartik Jhaveri, Lorenzo Mannelli, Valeria Panebianco, Scott Reeder, Reiko Woodhams
| S02 | Sunday 15:15 - 16:45 | Moderators: Masoom Haider & David Karow |
| 15:15 | Placenta & Pregnant Patient |
| Nathalie Siauve | |
Understanding placental functions remains largely concealed from non-invasive in vivo investigations, although placental insufficiency is responsible for most failures in pregnancy. Functional MRI offers new perspectives for placental imaging. The vascularisation can be studied with IVIM and the pseudo perfusion coefficient (D*) and the perfusion fraction (f), and with ASL and the blood flow (fASL). DCE MRI also provides a definite assessment of perfusion but requires an exogenous contrast agent. The oxygenation can be studied with BOLD. The placental structure can be studied with DWI and the apparent diffusion coefficient (ADC), and with IVIM and the diffusion coefficient (Dr). |
| 15:37 | Fetal MRI |
| Manjiri Dighe | |
This presentation will review the technique and common indication of fetal MRI with a review of the newer techniques at the end. Illustrative cases will be presented. |
| 15:59 | Renal & Adrenal Pathologies |
| Nicolas Grenier |
| 16:21 | MRU & Bladder |
| David Childs | |
MR urography has proven to be a robust technique for the assessment of the urothelium in both the pediatric (congenital anomalies) and adult (urothelial carcinoma) populations. Technical challenges (motion, contraindication to contrast, etc.) remain, although newer MRI techniques are increasingly providing solutions to these issues. The increasing use of diffusion and perfusion-weighted imaging has also provided the benefit of multi-parametric data. While the detection of urothelial carcinoma can be achieved with various endoscopic and urographic imaging tests, the accurate staging of tumors (both T and N stage) remains a challenge. Advances have been achieved in anatomic MRI, perfusion MRI, and diffusion weighted imaging for the T-staging of bladder carcinoma, although the assessment of nodal status remains a significant challenge. Newly described PET/MRI methods have shown promising results in improving both the specificity of focal urothelial lesions and accurate determination of nodal status, though research is ongoing. |
| 16:43 | Adjournment & Meet the Teachers |
Organizers: Fernando Boada, Elna-Marie Larsson
| S03 | Sunday 15:15 - 16:45 | Moderators: Fernando Boada & Elna-Marie Larsson |
| 15:15 | Dementia |
| Ian Law | |
The benefits of PET/MRI in dementia is still in development. There is no firm evidence to suggest added value of this hybrid technique for dementia work-our over sequential scanning besides convenience for patient and clinician. |
| 15:45 | Multimodal Simultaneous MR-PET Imaging |
| Irene Neuner | |
Simultaneous measurement of PET-MR-EEG has become feasible now a day with the aim of best utilizing the complementary information provided by each modality. Several studies have already shown the possibility of simultaneous measurement of PET-MR-EEG. However such possibility comes with technical and practical challenges. To that extent, we aim to give an overview about the technical challenges in integrating EEG in to hybrid PET-MR scanners and with possible solutions. |
| 16:15 | Epilepsy |
| Timothy Shepherd |
| 16:45 | Adjournment & Meet the Teachers |
Organizers: Stephan Maier, Jennifer McNab, Noam Shemesh
| S04 | Sunday 15:15 - 16:55 | Moderators: Jennifer McNab & Noam Shemesh |
| 15:15 | Looking from the Outside: Extracellular Diffusion |
| Dmitry Novikov | |
Diffusion in the extracellular space is considered as a function of an increasing diffusion time, equivalent to the coarse-graining of the cellular arrangement over an increasing diffusion length. The three major limits are covered: Short-time S/V limit; long-time limit of approaching the tortuosity asymptote; and the tortuosity limit. The relevant degrees of freedom of cell packing, distinct in each of the three limits, will be discussed. |
| 15:40 | Macro- vs. Micro-Anisotropy |
| Filip Szczepankiewicz | |
What are the distinguishing marks of anisotropic structures in a microscope, and how are these features reflected in the diffusion weighted signal? The lecture will survey the features of anisotropic diffusion on the micro- and macro-scale and connect them to the MRI experiments that may be used to probe such features. |
| 16:05 | How Small Is Small? Probing Very Small Compartment-Short Diffusion Time |
| Manisha Aggarwal | |
This lecture will cover the concepts and applications of oscillating-gradient diffusion MRI acquisition methods to probe tissue microstructure using short effective diffusion times. We will discuss how oscillating diffusion-encoding gradients can be used to characterize restricted diffusion in neuronal tissues, using selective sampling of the temporal diffusion spectrum D(ω) over discrete narrow frequency bands. We will then explore the applications as well as some current limitations of OGSE diffusion MRI acquisitions for probing tissue microstructure over varying length scales. |
| 16:30 | Panel Discussion |
| 16:55 | Adjournment & Meet the Teachers |
| Plenary Hall (Paris Room) | Sunday 17:30 - 18:15 |
| 17:00 | Welcome |
| 18:15 | How Early Life Events Shape Our Brain: An MRI Perspective |
| 18:15 | Adjournment |
| Exhibition Hall | Sunday 18:30 - 20:00 | (no CME credit) |
Organizers: Fernando Calamante, Hanzhang Lu, Steven Sourbron
| N03 | Monday 7:00 - 7:50 | Moderators: Lirong Yan & Irene Mikkelsen |
Organizers: Jongho Lee, Utaroh Motosugi, Yi-Fen Yen
| N04 | Monday 7:00 - 7:50 | Moderators: Utaroh Motosugi & Yi-Fen Yen |
| 7:00 | Basic Physics of Compressed Sensing |
| Jong Chul Ye |
| 7:25 | Clinical Applications of Compressed Sensing |
| Akira Yamamoto |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Kathryn Fowler, Catherine Hines, Kartik Jhaveri, Lorenzo Mannelli, Valeria Panebianco, Scott Reeder, Reiko Woodhams
| S01 | Monday 7:00 - 7:50 | Moderators: Kathryn Fowler & Marc Gollub |
| 7:00 | Staging/Pre-Op |
| Stephanie Nougaret |
| 7:25 | Response |
| Regina Beets-Tan |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Tim Leiner, Bernd Wintersperger
| S02 | Monday 7:00 - 7:50 | Moderators: Dana Peters & Walter Witschey |
| 7:00 | Respiratory motion correction |
| Markus Henningsson |
| 7:25 | Correcting Cardiac Motion |
| Keigo Kawaji |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Guanshu Liu, Natalie Serkova, Damian Tyler
| S03 | Monday 7:00 - 7:50 | Moderators: Gregory Metzger & Xiang Xu |
| 7:00 | Recent Technical Developments of Molecular MRI in Cancer Imaging |
| Willem Mulder |
| 7:25 | Clinical Translation & Applications of Molecular MRI in Cancer |
| Craig Malloy |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Eric Chang, Garry Gold, Emily McWalter, Edwin Oei, Philip Robinson
| S04 | Monday 7:00 - 7:50 | Moderators: Erin Englund & Hermien Kan |
| 7:00 | MRI of Muscle Physiology |
| David Bendahan |
| 7:25 | Clinical Muscle Imaging with Emerging Techniques |
| Kimberly Amrami |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Andre Obenaus, Pia Maly Sundgren
| S05 | Monday 7:00 - 7:50 | Moderators: Andre Obenaus & Natalie Zahr |
| 7:00 | Alcohol: WM & Alcohol |
| Natalie Zahr |
| 7:25 | Alcohol: Effects of Alcohol Using MRS |
| Mark Frye |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Gregor Adriany, Matthias Günther, Michael Hansen, Christoph Juchem, Greig Scott
| S06 | Monday 7:00 - 7:50 | Moderators: Mary McDougall & Greig Scott |
| 7:00 | Fabricating Electronics |
| Pascal Stang |
| 7:25 | Gradient Controller Tutorial |
| Michael Twieg |
| 7:50 | Adjournment & Meet the Teachers |
| Exhibition Hall 1271-1304 | Monday 8:15 - 10:15 | (no CME credit) |
| Exhibition Hall 1369-1393 | Monday 8:15 - 10:15 | (no CME credit) |
| Exhibition Hall | Monday 8:15 - 9:15 | (no CME credit) |
| Exhibition Hall | Monday 8:15 - 9:15 | (no CME credit) |
| W07 | Monday 8:15 - 9:15 | (no CME credit) |
| W08 | Monday 8:15 - 9:15 | (no CME credit) |
Organizers: Ulrich Katscher, Jose Marques, Stefan Ropele
| S05 | Monday 8:15 - 10:15 | (no CME credit) |
8:15
|
Introduction to Magnetic Susceptibility Mapping: From Magnetism to Magnetic Fields & Back to the Start! | |
1University of Nottingham |
8:35
|
QSM, the Quantitative & Qualitative Susceptibility Mapping | |
1Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Jena, Germany |
8:50
|
QSM Technical Implementation Challenges | |
1Cornell University, United States |
9:00
|
Roundtable: What Is Missing to Make QSM a Clinical Product? | |
9:00
|
Roundtable: What Is Missing to Make QSM a Clinical Product? | |
1Philips Healthcare |
9:00
|
Roundtable: What Is Missing to Make QSM a Clinical Product? | |
9:15
|
Iron Accumulation in Neurodegenerative Diseases & Aging: QSM as a New Tool in Clinical Research | |
9:35
|
Clinical Applications of a Myelin & Iron Biomarker: The Contribution of QSM to the Study of Multiple Sclerosis | |
9:55
|
Debate: Is QSM Ready for Clinical Use as a Diagnostic Tool? | |
1Hospital Universitari Vall D’Hebron |
9:55
|
Debate: Is QSM Ready for Clinical Use as a Diagnostic Tool? | |
1Konkuk University Medical Center |
Organizers: Franklyn Howe, Petra Huppi, Duan Xu
| W05/06 | Monday 8:15 - 10:15 | (no CME credit) |
8:15
|
Imaging Early Brain Development: Challenges & Potential of MRI in Infants | |
1Cognitive Neuroimaging Unit U992, INSERM, Gif-sur-Yvette, France |
8:45
|
Imaging Function in Developing Preterm Brain with Simultaneous EEG-fMRI | |
1Kings College London |
9:15
|
Quantitative MRI from Childhood to Young Adulthood, Development & Clinical Application | |
1UCL Institute of Child Health, United Kingdom |
9:45
|
Learning-Based Quantification of Baby Brain Development | |
1UNC-Chapel Hill |
Organizers: John Port, Martin Sherriff
| N01 | Monday 8:15 - 10:15 | Moderators: James Stuppino & John Port |
8:15
|
The Bright Future of AI/ML in Radiology | |
1Mayo Clinic, United States |
||
Artificial intelligence will result in substantial changes in the way that radiology and medicine are practiced. Portions of diagnosis and therapeutics that have a clear pattern are likely to be replaced, augmented, or improved with computer technologies. This will also happen more broadly in all of the world. We must be prepared for these changes, and with proper involvement, we can use this technology to improve everyone's lives. |
8:45
|
MR Tech View: Will AI/ML Put My Job at Risk? | |
1Brigham and Women's Hospital, United States |
||
MR Technology and our mother modality Radiology are on the brink of significant change. Computer programming and hardware exist to automat many functions once done by technologists or physicians. We are grudging moving forward to embrace these improvements. Somewhat untrusting and with great trepidation we struggle to balance faster exam times, greater ancillary tasks and new technology. We must carefully but quickly earn these new skills and build new workflows in our departments. MR Technologists are very resilient and with proper education and support can make this new world a better one for our patients and ourselves. |
9:15
|
Radiologist View: Will AI/ML Put My Job at Risk? | |
1University Hospitals Tuebingen, Germany |
||
The routine use of Artificial Intelligence (AI) in medicine and in medical imaging will become reality, that´s a fact. This is true not only for radiology, but for all medical professions. The question is, how fast this may happen, for which indications and clinical scenarios, and how this will be implemented in our routine workflows. Indeed, implementation and use of AI in radiology is even beneficial and wanted, given the exponentially rising demand of diagnostic imaging and radiological procedures. But will AI replace our profession? Will we have to stop training radiologists? Radiology is always changing and has always been developing alongside new technologies. Therefore, AI will not replace our profession, but it will change our work and it will make us have to train even more. There are a number of reasons why diagnostic radiology has a bright future, implementing AI and ML. |
9:45
|
Panel Discussion |
10:15
|
Adjournment & Meet the Teachers |
Organizers: Guanshu Liu, Arvind Pathak
| S02 | Monday 8:15 - 10:15 | Moderators: Robia Pautler & Xiaolei Song |
8:15
|
MRI Capable Theranostic Agents | |
1Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States |
||
New generation magnetic resonance imaging (MRI) contrast agents such as nanoparticles can be developed as theranostic agents which integrate the MRI contrast enhancing capability with therapeutic functions. The objective of this lecture is to give the audience an update of the recent developments in MRI enabled theranostics and stimulate the interests and new ideas to further advance the research and clinical translations of MRI enabled theranostics. The rational design of MRI capable theranostics agents, approaches for making the desired theranostic platforms, and MRI methods developed to enable MRI visualization of delivery processes will be discussed and presented with examples. |
8:55
|
Treatment Monitoring Using Smart MRI Agents | |
1Johns Hopkins Univ. Sch. of Medicine, United States |
||
In this presentation we will summarize the current state of molecular MRI using biologically active and/or targeted “smart” imaging agents to detect treatment response in several preclinical models of human diseases including cancer. Both methodological and biological aspects of the MR imaging strategies will be considered. We anticipate that by the end of the talk the audience should have improved understanding and appreciation of mechanisms and applications of novel state-of-the-art MRI imaging agents to various disease processes in preclinical models. |
9:35
|
Potential & Requirements for Clinical Translation | |
1University of Manchester, United Kingdom |
||
This presentation discusses clinical translation of novel agents. Firstly, the conventional diagnostic drug development pathway is outlined. Then six unconventional pathways are introduced and illustrated with examples from MR and other diagnostic imaging modalities. |
10:15
|
Adjournment & Meet the Teachers |
10:55
|
||
| TBD |
| Power Pitch Theater A - Exhibition Hall | Monday 8:15 - 9:15 | Moderators: sergio uribe & Michael Hope | (no CME credit) |
| 1 | 8:15
|
Non-invasive pressure estimations by virtual fields – cardiovascular pressure drops from 4D flow MRI |
1Department of Medical Engineering, KTH Royal Institute of Technology, Stockholm, Sweden, 2Clinical Sciences, Karolinska Institutet, Stockholm, Sweden, 3Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 4Department of Congenital Heart Disease, Evelina Children’s Hospital, London, United Kingdom, 5Departments of Surgery and Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, 6Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden |
| 2 | 8:15
|
The Effect of Model Compliance and Pulsatile Flow for In-Vitro Simulation of the Aorta |
1Mechanical Engineering, University of Wisconsin, Madison, WI, United States, 2Radiology, University of Wisconsin, Madison, WI, United States, 3School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States, 4Biomedical Engineering, University of Wisconsin, Madison, WI, United States |
| 3 | 8:15
|
3D Hemodynamics Characterization in Patients with Hypercholesterolemia using 4D Flow data and a Finite Element Method. |
1Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile, 2Department of Electrical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 3Department of Radiology and Biomedical Engineering, University of Texas Southwestern, Dallas, TX, United States, 4Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile, 5Department of Structural and Geotechnical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 6Department of Radiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile |
| 4 | 8:15
|
Caval Blood Flow Distribution in Fontan Circulation: Comparison between ASL-Measured Pulmonary Perfusion and 4D Flow |
1Bioengineering, University of Texas at Dallas, Richardson, TX, United States, 2Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 3Pediatrics, UT Southwestern Medical Center, Dallas, TX, United States, 4Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States |
| 5 | 8:15
|
Postoperative changes in volume flow rate in the thoracic aorta and the aortic arch branches in patients with aortic valve stenosis: a prospective serial 4D flow MRI study |
1Department of Diagnostic Radiology, Tohoku University Hospital, Sendai, Japan, 2Department of Electrical and Mechanical Engineering, Nagoya Institute of technology, Nagoya, Japan, 3School of Engineering, Tohoku University, Sendai, Japan, 4Siemens Japan K.K., Tokyo, Japan, 5Division of Cardiovascular Surgery, Tohoku University Hospital, Sendai, Japan, 6Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan |
| 6 | 8:15
|
4D-Flow-MRI analysis of aortic flow patterns after replacement of the ascending aorta with a physiologically pre-shaped, 90° bent prosthesis |
1Department of Radiology and Nuclear Medicine, University Hospital Schleswig-Holstein, Luebeck, Germany, 2Department of Cardiac and Cardiothoracic Vascular Surgery, University Hospital Schleswig-Holstein, Luebeck, Germany, 3Fraunhofer MEVIS, Bremen, Germany |
| 7 | 8:15
|
Impact of field strength (1.5, 3.0 and 7.0 Tesla) and sequence on quantification of aortic flow volumes, peak velocity and wall shear stress using 4D flow MRI |
1Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular Medicine and HELIOS Hospital Berlin Buch, Department of Cardiology and Nephrology, Berlin, Germany, 2DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, Germany, 3Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, 4SCO:SSIS Statistical Consulting, Berlin, Germany, 5Clinic Agatharied, Department of Cardiology, Ludwig-Maximilians-University Munich, Hausham, Germany, 6Siemens Healthcare, Erlangen, Germany, 7Department of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, IL, United States |
| 8 | 8:15
|
Quantifying the Impact of Velocity Field Distortions on Particle Tracking Techniques |
1Linköping University, Linköping, Sweden, 2Center for Medical Image Science and Visualization (CMIV), Linköping, Sweden, 3University Hospital Linköping, Linköping, Sweden |
| 9 | 8:15
|
Quantitative MRI detects acute vascular effects of e-cig aerosol inhalation |
13400 Spruce St, University of Pennsylvania, Philadelphia, PA, United States, 2Radiology, University of Pennsylvania, Philadelphia, PA, United States, 3University of Pennsylvania, Philadelphia, PA, United States |
| 10 | 8:15
|
Accelerating 4D-Flow Acquisitions by Reducing TE and TR with Optimized RF and Gradient Waveforms |
1Radiological Sciences, University of California, Los Angeles, CA, United States, 2Bioengineering, University of California, Los Angeles, CA, United States, 3Biomedical Physics, University of California, Los Angeles, CA, United States |
| 11 | 8:15
|
A Dual Echo, Dual VENC (DEDV) phase contrast method for Simultaneous Measurement of Myocardial and Blood Flow Velocities |
1Physics and Texas Center for Superconductivity, University of Houston [Main Campus], HOUSTON, TX, United States, 2Baylor St. Luke's Medical Center, Houston, TX, United States |
| 12 | 8:15
|
30 times accelerated 4D flow MRI in the carotids using a Pseudo Spiral Cartesian acquisition and a Total Variation constrained Compressed Sensing reconstruction |
1Radiology and Nuclear Medicine, Academic Medical Center (AMC), Amsterdam, Netherlands, 2Biomedical Engineering and Physics, Academic Medical Center (AMC), Amsterdam, Netherlands |
| 13 | 8:15
|
Alterations of Cardiac 4D Hemodynamics and Blood Energetics in Hypertrophic Cardiomyopathy |
1Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 2Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Chicago, IL, United States, 3Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States |
| 14 | 8:15
|
Dynamic flow imaging and quantification using cine FISS arterial spin labeling |
1Radiology, NorthShore University HealthSystem, Evanston, IL, United States, 2Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 3Medicine, NorthShore University HealthSystem, Evanston, IL, United States, 4Siemens Medical Systems, Chicago, IL, United States, 5Radiology, Prtizker School of Medicine, University of Chicago, Chicago, IL, United States |
| 15 | 8:15
|
4D Flow Cardiac MRI Using Semi-Automated Retrospective Valve Tracking for Assessment of Severe Mitral Insufficiency |
1Academic Medical Center Amsterdam, Amsterdam, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Utrecht University Medical Center, Utrecht, Netherlands, 4Pie Medical Imaging, Maastricht, Netherlands |
| Power Pitch Theater B - Exhibition Hall | Monday 8:15 - 9:15 | Moderators: Fraser Robb & Natalia Gudino | (no CME credit) |
| 16
|
8:15
|
The iPRES-W AIR Coil: A Flexible RF Coil for Simultaneous MR Image Acquisition, Wireless Communication, and Localized B0 Shimming |
1Brain Imaging Analysis Center, Duke University, Durham, NC, United States, 2Medical Physics Graduate Program, Duke University, Durham, NC, United States, 3GE Healthcare, Aurora, OH, United States |
| 17
|
8:15
|
Towards wearable MR detection: A stretchable wrist array with on-body digitization |
1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2Electronics Laboratory, ETH Zurich, Zurich, Switzerland, 3Integrated Systems Laboratory, ETH Zurich, Zurich, Switzerland |
| 18 | 8:15
|
High Impedance Detector Arrays for Magnetic Resonance |
1Bernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States, 2Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, NY, United States, 3The Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, NY, United States |
| 19 | 8:15
|
Highly Flexible, Light Weight 24 Channel 3T Bilateral Brachial Plexus Array Worn as a Close Fitting Variable Size Vest |
1G. E. Healthcare Technologies, Aurora, OH, United States, 2G. E. Healthcare Technologies, Waukesha, WI, United States, 3Radiology, University of California, San Diego, La Jolla, CA, United States, 4Radiology, VA San Diego Healthcare System, San Diego, CA, United States, 5Electrical Engineering, University of California, San Diego, La Jolla, CA, United States |
| 20 | 8:15
|
Custom, 3D Sprayed MRI receive coils |
1EECS, UC Berkeley, Berkeley, CA, United States, 2Georgia Institute of Technology, Atlanta, GA, United States, 3ME, UC Berkeley, Berkeley, CA, United States |
| 21
|
8:15
|
First clinical pilot study using screen-printed flexible MRI receive coils for pediatric applications |
1Department of Radiology, Stanford University, Stanford, CA, United States, 2University of California Berkeley, Berkeley, CA, United States, 3Lucile Packard Children's Hospital Stanford, Stanford, CA, United States, 4GE Healthcare, Aurora, OH, United States, 5Department of Electrical Engineering, Stanford University, Stanford, CA, United States |
| 22 | 8:15
|
Volumetric resonators based on novel materials for 3 T MRI |
1Department of Nanophotonics and Metamaterials, ITMO University, Saint Petersburg, Russian Federation, 2Department of Radiology, Vreden Russian Institute of Traumatology and Orthopedics, Saint Petersburg, Russian Federation, 3Nonlinear Physics Center, Research School of Physics and Engineering, Australian National University, Canberra, Australia, 4C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands |
| 23 | 8:15
|
New ferroelectric ceramics for transmit efficiency enhancement at 1.5 Tesla |
1Radiology Department, C.J. Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands, 2Department of Nanophotonics and Metamaterials, ITMO University, Saint Petersburg, Russian Federation, 3Giricond Research Institute, Ceramics Co., Saint Petersburg, Russian Federation |
| 24
|
8:15
|
Comparison of a 16-channel monopole/dipole hybrid array with a combined 8-channel monopole + 8-channel high dielectric constant (HDC) disk dipole array for head imaging at 10.5T |
1Center for Magnetic Resonance Research, Minneapolis, MN, United States |
| 25 | 8:15
|
Pilot Tone Software Synchronization for Wireless MRI Receivers |
1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Stanford University, Stanford, CA, United States, 3GE Healthcare, Aurora, OH, United States, 4Procyon Engineering, San Jose, CA, United States |
| 26
|
8:15
|
Demonstration of a new volumetric wireless coil for extremities imaging |
1Department of Nanophotonics and Metamaterials, ITMO University, Saint Petersburg, Russian Federation, 2Centre for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands |
| 27 | 8:15
|
High Precision Wireless Clock Recovery for On-Coil MRI Receivers Using Round-Trip Carrier Phase Tracking. |
1Invivo Corporation, Gainesville, FL, United States, 2Philips Research, Hamburg, Germany |
| 28 | 8:15
|
Antenna Design for Wireless Clock Syncing and Q-spoiling in MRI |
1Stanford University, Stanford, CA, United States, 2GE Healthcare Inc., Stanford, CA, United States, 3GE Healthcare Inc., Aurora, OH, United States |
| 29
|
8:15
|
3D imaging with a portable MRI scanner using an optimized rotating magnet and 1D gradient coil |
1Massachusetts Institute of Technology, Cambridge, MA, United States, 2Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 3Harvard Medical School, Boston, MA, United States |
| 30 | 8:15
|
Portable single-sided MR: multicomponent T2 relaxometry and depth profiling with a Unilateral Linear Halbach sensor |
1Electrical Engineering & Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 2David H. Koch Institute For Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States, 3A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 4Harvard Medical School, Boston, MA, United States, 5Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States |
Organizers: Michael Lustig, Demian Wassermann
| S01 | Monday 8:15 - 10:15 | Moderators: Oliver Bieri & Christiane Kuhl |
8:15
|
Clinical Needs | |
1Case Western Reserve University, United States |
8:45
|
Technical Trends | |
1University of Wisconsin-Madison, United States |
| 31 | 9:15
|
Non-ECG, free-breathing myocardial T1-T2 mapping of acute myocardial infarction using low-rank tensor MR multitasking |
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Department of Radiology, Xuanwu Hospital, Beijing, China |
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Myocardial tissue characterization by T1-T2 mapping is promising for diagnosing myocardial infarction, ischemia, and more. This is typically performed using ECG triggering and breath-holding, which is uncomfortable and unreliable in patients. This work describes a novel method for non-ECG free-breathing joint T1-T2 mapping using cardiovascular MR multitasking, modeling the underlying 6D multidimensional image—which has 2 spatial dimensions + 4 time dimensions (cardiac, respiratory, T1, and T2)—as a low-rank tensor. T1 and T2 measurements in acute myocardial infarction patients agreed with reference methods and predicted late gadolinium enhancement with 100% sensitivity and 92% specificity. |
| 32
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9:27
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5D Flow MRI – Respiratory Motion Resolved Accelerated 4D Flow Imaging Using Low-Rank + Sparse Reconstruction |
1ETH Zurich, Zurich, Switzerland |
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We present a low-rank + sparse reconstruction method which resolves respiratory motion in 4D flow magnetic resonance imaging as a low-rank signal component. Respiratory motion resolved 4D flow MRI data is reconstructed and compared to the total variation based XD-GRASP method and a standard parallel imaging acquisition protocol. Good agreement of the reconstructed results with the reference shows that a low-rank model is effective in resolving respiratory motion in 4D flow magnetic resonance imaging. |
| 33 | 9:39
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Multi-echo Magnetic Resonance Fingerprinting: Simultaneous derivation of T1, T2, B0, T2*, T2', Tx/Rx phase maps, and T2*-corrected magnitude maps in in-vivo and phantom studies |
1Tomographic Imaging, Philips Research Europe, Hamburg, Germany |
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This work describes a Magnetic Resonance Fingerprinting (MRF) implementation using multiple echo acquisitions within one TR. In this way, B0, T2*, R2', and Tx/Rx phase maps are derived in addition to the standard M0, T1, and T2 maps, as demonstrated in in-vivo and phantom experiments. Accounting for the difference in T2 and T2*, the inherent bias of MRF-derived M0 maps can be corrected. The derived R2' map may have diagnostic relevance for neurodegenerative diseases. |
| 34 | 9:51
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MP2RAGEME: T1, T2* and QSM mapping in one sequence at 7 Tesla |
1Radiology, Academic Medical Center, Amsterdam, Netherlands, 2Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, 3Social Brain Laboratory, Netherlands Institute for Neuroscience, Amsterdam, Netherlands, 4Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 5Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands |
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Quantitative T1, T2* and QSM information can be acquired in a single acquisition, using a multi-echo extension of the MP2RAGE sequence, MP2RAGEME. This simultaneous acquisition results in large time savings, perfectly coregistered data and minimal image quality differences. Following a correction for residual transmit B1-sensitivity quantitative T1 and T2* and QSM-values were in excellent agreement with those obtained from separately acquired MP2RAGE and GRE data. Values were also in correspondence with literature. From the MP2RAGEME data, a multiparametric cortical parcellation was obtained, as well as a combined arterial and venous map. |
| 35 | 10:03
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Simultaneous Proton Density Fat Fraction Imaging and Water T1-Mapping with Low B1+ Sensitivity (PDFF-T1) |
1Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc., Chicago, IL, United States |
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Quantitative multi-parametric MR imaging is an important component of diagnosis and objective staging of diffuse liver disease, reducing the need for biopsy. The goal of the current study was to validate a new simultaneous proton density fat fraction and water T1-mapping approach (PDFF-T1) with low B1+ sensitivity in a short, patient-friendly breath-hold acquisition. It is shown (simulations, phantoms, in-vivo) that a time-varying flip angle excitation scheme leads to improved accuracy of PDFF and that fat-water separation enables water-specific T1 mapping, all in a single patient-friendly breath-hold, with low sensitivity to inhomogeneity in the transmitted radiofrequency (B1+) field. |
10:15
|
Adjournment & Meet the Teachers |
| N02 | Monday 8:15 - 10:15 | Moderators: Stamatios Sotiropoulos & Robert Smith |
| 36
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8:15
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Super-resolution for spherical deconvolution of multi-shell diffusion MRI data |
1imec-Vision Lab, Dept. of Physics, University of Antwerp, Antwerp, Belgium, 2Dept. of Radiology, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium |
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Multi-tissue constrained spherical deconvolution (MT-CSD) can simultaneously estimate the full white matter fiber orientation distribution function (fODF) and the apparent densities of cerebrospinal fluid and grey matter from multi-shell diffusion MRI data, making it an attractive option for clinical and neuroscientific studies. Unfortunately, MT-CSD at high spatial resolution is challenging due to scan time and signal-to-noise ratio constraints. We propose a new MT-CSD approach that enables super-resolution estimation from multiple thick-sliced data sets with varying slice orientation. Using data acquired on a clinical scanner, we demonstrate high-quality tissue density maps and fODFs at 1×1×1mm3 spatial resolution in under 10 minutes. |
| 37
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8:27
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Differential Sensitivity of Various Microstructural Metrics to Training-Induced White Matter Dynamics |
1Cardiff University Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 2Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 3Department of Neurobiology, Tel Aviv University, Tel Aviv, Israel, 4Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel |
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Previous in-vivo MRI studies on training-induced WM microstructural dynamics were mostly based on DTI measurements showing changes in FA. The non-specificity of FA as a WM marker stimulated us to obtain a more specific characterization of WM microstructural changes. Using multi-parametric MR with the ‘Tractometry’ approach we show significant changes in the fornix post a navigation working memory task. Critically, we report here for the first time significant microstructural changes with susceptibility, shown in vast areas of the fornix. Fr, MD, RD and λ1 also show significant changes but in limited areas of the fornix. |
| 38 | 8:39
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Reducing false positives in tractography with microstructural and anatomical priors |
1Computer Science department, University of Verona, Verona, Italy, 2Signal Processing Laboratory 5 (LTS5), Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland, 3Radiology department, University Hospital Center (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 4Sherbrooke Connectivity Imaging Laboratory (SCIL), University of Sherbrooke, Sherbrooke, QC, Canada, 5Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Science, Sherbrooke Molecular Imaging Center, Sherbrooke, QC, Canada |
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Tractography has proven particularly effective for studying noninvasively the neuronal architecture of the brain but recent studies have showed that the high incidence of false positives can significantly bias any connectivity analysis. We present a novel processing framework that can dramatically reduce these false positives, i.e. improving specificity, without affecting the sensitivity, by considering two very basic observations about white-matter anatomy. Our results may have profound implications for the use of tractography to study brain connectivity. |
| 39
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8:51
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Fast and accurate white matter bundle segmentation |
1Division of Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Medical Faculty, University of Heidelberg, Heidelberg, Germany |
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Automatic white matter fiber bundle segmentation in diffusion-weighted MRI brain scans enables detailed studies of white matter characteristics in healthy and diseased brains. Existing approaches combine processing steps such as tractography, atlas registration and cortical parcellation, resulting in pipelines that are computationally intensive and tedious to set up. We present a novel convolutional neural network-based approach that incorporates or circumvents most of the usually required processing steps (no registration, no tracking, no parcellation). We demonstrate in 105 subjects from the Human Connectome Project that the proposed approach is much faster than existing methods while providing more accurate results. |
| 40 | 9:03
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A data-driven groupwise fiber clustering atlas for consistent white matter parcellation and anatomical tract identification of subjects across the lifespan |
1Harvard Medical School, Boston, MA, United States |
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We propose an anatomically curated white matter parcellation atlas generated from a large population of 100 healthy adult subjects, leveraging a well-established data-driven groupwise fiber clustering pipeline and expert neuroanatomy knowledge. We demonstrate the ability of the proposed method to parcellate a total of 541 subjects ranging in age from 1 day to 82 years. The results suggest that our parcellation algorithm provides high generalization and consistency of white matter parcellation and tract identification for subjects across the lifespan. |
| 41 | 9:15
|
Bundle-Wise Deep Tracker: Learning to track bundle-specific streamline paths |
1University of Sherbrooke, Sherbrooke, QC, Canada |
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We propose a novel bundle-wise tracking algorithm based on deep learning and recurrent neural networks. This allows bundle-specific features to be learned directly from the diffusion signal without the need to reconstruct a fiber orientation distribution. With a high amount of examples, the proposed method improves classic algorithms for several quantitative measures such as tracking efficiency, number of valid streamlines, and volume coverage. |
| 42 | 9:27
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Anchor tracts: a novel concept for reducing false positives in fiber tractography |
1Division of Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany |
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Numerous reports have shown that fiber tractography suffers from a difficult sensitivity-specificity tradeoff. We present an approach that leverages knowledge about certain well studied tracts (anchor tracts) in a tractogram to quantitatively assess and score the remaining tracts (candidate tracts) according to their plausibility in conjunction with this context information. We show that our approach has the potential for greatly reducing the number of false positive tracts in fiber tractography while maintaining high sensitivities. |
| 43
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9:39
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Investigating U-Shape Fibers from Data-Driven Clustering of White Matter Tractography |
1Medical Biophysics, Western University, London, ON, Canada, 2Biomedical Engineering, Western University, London, ON, Canada, 3Robarts Research Institute, Western University, London, ON, Canada |
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Studies of white matter tractography typically investigate fibers that make up long association tracts, such as the arcuate fasciculus. As a result, the local structural connections comprising short association (cortico-cortical), U-shaped fibers, or U-fibers, are poorly understood. Previous work suggests these fibers play an important role in communication between adjacent cortical regions. We introduce a flexible, data-driven tool incorporating multimodal MRI techniques to aid differentiation of fiber tracts via clustering techniques, including a filter to identify and extract U-fibers. Using this tool, we present a preliminary investigation of U-fibers between controls (N=20) and patients diagnosed with temporal lobe epilepsy (N=19). |
| 44 | 9:51
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Tractography-based parcellations show limited sensitivity to internal structure |
1Developmental Imaging and Biophysics Section, UCL GOS Institute of Child Health, University College London, London, United Kingdom, 2Neuroradiological Academic Unit, UCL Institute of Neurology, University College London, London, United Kingdom, 3Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London, United Kingdom |
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Connectivity-based parcellation of subcortical structures using diffusion tractography is a common paradigm. Typically, these analyses imply voxel-level specificity of connectivity, and spatial coherence is taken as imaging-based evidence for anatomically distinct subnuclei. However, by spatially permuting diffusion parameters and repeating the parcellation, we demonstrate that internal structure in diffusion anisotropy is not necessary for a plausible parcellation to be obtained. This suggests that such parcellations should be interpreted with some caution. |
| 45 | 10:03
|
Ultra-high resolution multi-shell dMRI and tractography of the ex vivo human brain using kT-dSTEAM at 9.4T |
1Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands |
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Here we explore the high resolution acquisition of multi-shell and undersampled diffusion data with 9.4T kT-dSTEAM and analysis of such data for crossing fiber tractography. This permits effective usage of both high SNR and diffusion-weighting inherent to data with multiple b-values and shows superior definition of white matter tracks at ultra-high resolution for tractography. In addition, 3D undersampled acquisition allows more room in the trade-off between acquisition time, resolution, b-values and directions. |
| N03 | Monday 8:15 - 10:15 | Moderators: Kai-Hsiang Chuang & Ian Driver |
| 46 | 8:15
|
Covariation of pulse oximetry amplitude and BOLD fMRI across vigilance states |
1NIH, Bethesda, MD, United States |
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While pulse oximetry (PO) is often used with fMRI to provide the timing of heart beats, few studies have focused on fluctuations in the amplitude of PO waveform in the context of fMRI signals. Here, we examine correlations between spontaneous fMRI signals and PO amplitude (POA) variations, observing a strong dependence on vigilance state. During alertness, POA-fMRI correlations were weaker but encompassed regions comprising the default-mode network. During drowsiness and NREM sleep, POA co-varied extensively with BOLD signals across the brain. |
| 47
|
8:27
|
Mechanisms underlying negative fMRI response in the striatum |
1Neurology & Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 3Duke University, Durham, NC, United States, 4Stanford University, Stanford, CA, United States, 5National Institute of Environmental Health Sciences, Durham, NC, United States, 6Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States |
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Optogenetic stimulation of striatal neurons and several afferents evoke robust negative fMRI responses in the striatum, while striatal electrophysiological recordings during the same stimulations show increases in neuronal activity. Pharmacological manipulations during D1MSN-induced negative striatal responses suggest responses are downstream of MSN activity, but not interneurons or local DA release. Fiber-photometry data from D2MSNs shows a similar pattern of neurovascular uncoupling/negative coupling. This negative fMRI response is also apparent in the human brain. Our results indicate that positive BOLD in the striatum is mediated through DA release, and that negative BOLD in the striatum is induced by local neuronal activations. |
| 48 | 8:39
|
Visually evoked negative BOLD signal coupled with silenced neuronal activity; an fMRI and intra-cranial electrocorticography study in humans |
1Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, 2University Medical Centre Utrecht, Utrecht, Netherlands |
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Neuroimaging techniques provide a unique window on the study of human brain function in healthy as well as pathological conditions. Intra-cranial electrocorticography (ECoG) at high frequency broadband power is associated with positive blood-oxygenation-level-dependent signal, but the electrophysiological correlates of negative BOLD signals are are less well understood. Here we investigate the relationship between negative BOLD and neuronal population activity measured with ECoG, in humans, using a paradigm that excludes blood stealing as a source of negative BOLD signal. |
| 49 | 8:51
|
Visual contrast levels modulate excitation and inhibition in the human visual cortex – a combined fMRI-MR Spectroscopy study at 7 Tesla |
1Wellcome Centre for Integrative Neuroimaging, FMRIB Division, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom, 3College of Health and Human Sciences, Purdue University, West Lafayette, IN, United States |
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We used 7 Tesla combined fMRI-MRS to show that simultaneously measured hemodynamic and neurochemical responses in the human visual cortex changed as a function of visual contrast. BOLD change increased linearly to rise in visual contrast, glutamate increased and GABA decreased. Quantification of this change using an excitation:inhibition index demonstrated a switch from inhibitory-dominant to excitatory-dominant neurochemical response. Our results are a step towards disambiguating contributions of cortical excitation and inhibition to stimulus evoked hemodynamic response. |
| 50 | 9:03
|
The potential for gas-free measurements of absolute oxygen metabolism during both baseline and activation states in the human brain |
1Neurosciences Graduate Program, Medical Scientist Training Program, University of California, San Diego, La Jolla, CA, United States, 2Center for Functional MRI, University of California, San Diego, La Jolla, CA, United States, 3Radiology, Stanford University, Stanford, CA, United States, 4Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, CA, United States, 5Psychiatry, Center for Human Development, University of California, San Diego, La Jolla, CA, United States, 6Radiology, University of California, San Diego, La Jolla, CA, United States |
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We tested noninvasive methods to measure absolute oxygen metabolism (CMRO2) in both baseline and activation states without the use of special gases: VSEAN to measure baseline O2 extraction fraction (OEF), and FLAIR-GESSE to measure R2’ to estimate the scaling parameter M. Primary findings were: M derived from R2’ had less variation across subjects compared to hypercapnia-derived M; OEF values were in good agreement with previous PET findings; and, variation of baseline CBF/CMRO2 coupling across subjects does not follow activation coupling, suggesting different mechanisms may be involved. These results support the potential of gas-free methods for quantitative physiological measurements. |
| 51 | 9:15
|
The dynamic BOLD-CBF coupling during resting-state in the aging brain: a dual-echo pCASL study |
1Neuroscience, Imaging and Clinical Sciences, Department of Neuroscience, Imaging and Clinical Sciences - Institute for Advanced Biomedical Technologies, Chieti, Italy |
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Simultaneous acquisition of BOLD and CBF data using ASL allows the study of resting-state brain function from a different perspective with respect to functional connectivity. In particular, recent evidence showed that spontaneous BOLD and CBF fluctuations are strongly coupled in the cortex. Here we show that this coupling is markedly reduced in elderlies with normal cognitive scores, with a regional specific effect in the left supramarginal gyrus, an area known to be involved in different memory functions. These findings suggest that the study of dynamic BOLD-CBF coupling can potentially offer early biomarkers of functional changes in the aging brain. |
| 52 | 9:27
|
Dynamic measurement of oxygen extraction fraction using a Multiple‑Offset‑Spin‑Echo Echo‑Planar Imaging (MOSE‑EPI) pulse sequence |
1Center for MRI Research, Peking University, Beijing, China, 2MR Research China, GE Healthcare, Beijing, China |
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The development of neuroimaging methods to detect functional oxygen extraction fraction (OEF) is crucial for understanding mechanisms of physiologic function and the underlying neuronal activities. However, dynamic measurement of the OEF is currently limited by the long acquisition time. In this study, a novel pulse sequence using a multiple-offset-spin-echo (MOSE) with an echo-planar imaging (EPI) acquisition scheme was developed to improve the temporal resolution of dynamic OEF measurements. A motor task experiment was performed for ten subjects. The OEF activation maps generated through the proposed technique and compared to traditional blood oxygenation level-dependent (BOLD) activation maps. |
| 53 | 9:39
|
Influence of end-tidal CO2 on cerebrovascular reactivity mapping: within-subject and across-subject effects |
1Division of MR Research, Johns Hopkins University, Baltimore, MD, United States, 2Johns Hopkins University, Baltimore, MD, United States, 3National Institutes of Health, Bethesda, MD, United States |
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The relationship between end-tidal (Et) CO2, and the output measure, BOLD signal, is highly non-linear, due to both physiological non-linearity between cerebral blood flow (CBF) and CO2 as well as biophysical non-linearity between CBF and BOLD. In this study, we found that, across subjects, baseline EtCO2 and ΔEtCO2 inversely influenced the measured CVR values. Therefore, these factors should be taken into account when comparing CVR between groups or patients. However, these inter-subject differences appear to have an independent physiological underpinning, as manipulations of these factors within the subject did not seem to have an effect on the measured CVR values. |
| 54 | 9:51
|
Hemodynamic response altered by focused ultrasound-mediated disruption of the blood-brain barrier |
1Brigham and Women's Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Boston Children's Hospital, Boston, MA, United States |
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Focused ultrasound (FUS) disruption of the blood-brain barrier (BBB) is a promising technology for achieving targeted delivery of pharmacological agents into the brain. While the method has been shown to be safe from the standpoint of not damaging tissue cells, it causes other changes to local physiology that are not fully understood. This study aims to characterize the effects on the hemodynamic response that FUS BBB opening causes. We present BOLD fMRI data showing the effect and preliminary ASL measurements of cerebral blood flow designed to better understand the effect. |
| 55
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10:03
|
Active, neuronal-activity-dependent trans-membrane water cycling detected by NMR |
1Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy For Advanced Studies, Zhejiang University, Hangzhou, China, 2Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 3Section on Critical Brain Dynamics, LSN, NIMH, National Institutes of Health, Bethesda, MD, United States, 4Section on Quantitative Imaging and Tissue Sciences, DIBGI, NICHD, National Institutes of Health, Bethesda, MD, United States |
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Transmembrane water cycling has long been thought an entirely passive, diffusion-dominated process. Recent studies suggest that an energetically active water cycling (AWC) mechanism, driven by Na+-K+-ATPase (NKA) pump activity, also occurs in different cell types, including neurons and astrocytes. Here we hypothesize that monitoring AWC could provide a new, more direct physical indicator of neuronal activity, which involves much ion cycling and enhanced NKA activity. By investigating neuronal populations in vitro under resting conditions with spontanotanous activity, and perturbed with tetrodotoxin (TTX), we found TTX simultanously reduces neuronal spiking activity and AWC (by >63%) suggesting AWC directly reflects neuronal activity. |
| N04 | Monday 8:15 - 10:15 | Moderators: Gigi Galiana & Christian Guenthner |
| 56 | 8:15
|
High Spatial Resolution BOLD fMRI Using Simultaneous Multislice Excitation with Echo-Shifting Gradient Echo at 7 Tesla |
1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Department of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China, 3Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China |
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Signal to noise gain at ultra-high field has pushed blood oxygen level dependent functional MRI towards high spatial resolution with the benefit of improved accuracy in functional mapping. However, the techniques available for high spatial resolution fMRI are mainly based on echo-planar imaging technique, which faces geometric distortion. In this work, we proposed a technique combining simultaneous multislice excitation with echo-shifting, which can be virtually free from distortion artifacts, for high spatial resolution fMRI. Significant activation was identified in visual and motor experiments with in-plane resolution of 1.0×1.0 mm2 and an acceleration factor of 10 at 7 Tesla. |
| 57 | 8:27
|
Simultaneous Multi-VENC and Multi-Slice (SMVMS) Phase Contrast Imaging Using Dual Steady-State Sequence |
1Helen Wills Neuroscience Institute, University of California, Berkeley, CA, United States, 2Advanced MRI Technologies, Sebastopol, CA, United States |
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Phase contrast (PC) MRI has been successfully applied to quantify flow velocity over the cardiac cycle by adding bipolar gradients with opposite polarity to cine gradient echo (GRE) sequences with prospective cardiac gating. However, PC-MRI suffers from a couple of disadvantages: 1) velocity aliasing which requires multiple acquisition without prior knowledge of the highest potential velocity and 2) excessive lengthy scan with whole brain coverage. In this work, we propose the Simultaneous Multi-VENC and Multi-Slice (SMVMS) technique to eliminate both issues. Instead of sequentially acquiring multiple slices with low and high velocity encoding (VENC) schemes, this interleaves an echo-shift technique in a Dual TR Steady-State (DSS) sequence using SMS excitation, which allows fast acquisition by sharing low- and high-VENC acquisitions with multiple slices in a single measurement. |
| 58 | 8:39
|
Diffusion interleaved and slice-shuffled (DiSS) imaging for joint diffusion-relaxometry studies |
1Biomedical Engineering, King's College London, London, United Kingdom, 2Centre for Medical Image Computing, University College London, London, United Kingdom |
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Imaging protocols that allow diverse contrast mechanisms to be sampled with different mixes open up exciting opportunities for joint modelling of tissue properties. However joint sampling with conventional sequence structures can be extremely inefficient and so prohibitively time consuming. Here we explore the joint inversion recovery-diffusion sampling challenge and create an efficient capability by breaking the “one-volume – one encoding” paradigm to interleave the diffusion encoding not per volume but for every slice. Flexible sampling during inversion recovery allowing sufficient samples for a joint fit to be acquired in a much shorter time. The approach has been tested in normal volunteer brain examinations. |
| 59 | 8:51
|
High Contrast and Resolution Simultaneous T1 and T2 MPRAGE at 7T |
1MRRC, Dept. of Radiology, University of Pittsburgh, Pittsburgh, PA, United States |
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T2W MRI is useful for lesion detection in neurological disorders. At 7T, while SNR can be excellent for high-resolution imaging, T2W imaging is known to be difficult due to problems with B1 amplitude and homogeneity, as well as low T2 contrast between WM vs. GM. To address these, we developed new simultaneous T1W/T2W MP2RAGE sequence. We simulated the new sequence to optimize brain contrast and implemented on 7T combined with B1-shimmed pTx multi-transceiver and high-order B0 shim. The results show homogeneous contrast of WM vs. GM over whole brain with excellent SAR efficiency, giving high resolution detection of hippocampal sub-structures. |
| 60 | 9:03
|
A 2D multi-shot inversion recovery EPI (MS-IR-EPI) sequence for high spatial resolution T1-mapping at 7T |
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 3University of Amsterdam, Amsterdam, Netherlands |
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The present study uses an efficient 2D, multi-shot, inversion-recovery EPI (MS-IR-EPI) acquisition that combines separately excited k-space segments after each inversion pulse together with steps in slice ordering to generate T1-maps with high SNR per unit time. We show that although the inversion times systematically vary across slices, consistent T1-maps can be generated across the whole brain. Such T1-maps provide high spatial resolution and SNR, with little image distortion and can be collected in a short acquisition time. |
| 61 | 9:15
|
Silent, 3D MR Parameter Mapping using Magnetization Prepared Zero TE |
1ASL Europe, GE Healthcare, Munich, Germany, 2Neuroimaging, King’s College London, London, United Kingdom |
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Here we describe a novel method for 3D, quantitative, silent MR parameter mapping based on 1) combined T1 and T2 magnetization preparation, 2) Zero TE image encoding and 3) least-squares dictionary matching. |
| 62 | 9:27
|
Multiband zoom TSE imaging: increasing efficiency with multiband tip-back preparation pulses |
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom |
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Inner volume imaging can be appealing as it negates the need to encode a large field of view when the region of interest resides within a larger tissue structure. However, conventional zoom approaches with precisely limited field of view produce strong saturation throughout the image volume, placing a restrictive lower limit on the minimum TR, in order to avoid reduced signal and contrast. Here we present a new multiband tip-back preparation pulse in combination with a zoom multiband TSE sequence, which realises the benefits of reduced field of view encoding without the penalty of saturation in the intermediate slice areas. |
| 63 | 9:39
|
Simultaneous Magnetic Resonance Angiography and Multiparametric Mapping in the Transient-state |
1Technical University of Munich, Munich, Germany, 2GE Global Research, Munich, Germany, 3Imago7 Foundation, Pisa, Italy |
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Quantitative Transient-state Imaging (QTI) is a non-random, dictionary-less MR Fingerprinting alternative. Through iterative reconstructions, QTI recovers a series of contrast-weighted images from transient-state acquisitions and subsequently estimates the parameters that best describe the resulting dynamic signal evolutions. Here, we extend the QTI framework by incorporating a simple velocity model that accounts for blood flowing into and out of the imaging slice. The model, however wrong, can be very useful: it predicts signal hyperintensities in the presence of flow, allowing for the simultaneous reconstruction of MR Angiography images, hundreds of dynamic contrast-weighted images, and their corresponding parametric maps. |
| 64 | 9:51
|
Novel Tumor-Selective Dual-Contrast 3D MRI Toward Zero False-Positiveness in Brain Metastases: A Feasibility Study |
1Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Republic of Korea, 2Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea, 3Department of Biomedical Engineering, Sungkyunkwan University (SKKU), Suwon, Republic of Korea |
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The purpose of this work is to develop a novel, tumor-selective dual-contrast 3D MRI technique that can clearly differentiate small brain metastases from contrast-enhanced vessels while potentially eliminating false-positiveness in the corresponding diagnosis. After injecting contrast agents, the proposed pulse sequence employs a pair of mixed encodings in each TR, yielding highly tumor-selective, blood-suppressed images from the latter to increase the sensitivity of metastases detection while producing blood-enhanced signals from the former to evaluate the false-positiveness of the detected metastases. It is expected that the proposed method enhances detection sensitivity to brain metastases while substantially reducing false-positiveness. |
| 65
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10:03
|
Clinical Imaging Potential of FRONSAC |
1Department of Biomedical Engineering, Yale University, New Haven, CT, United States, 2Department of Diagnostic Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany, 3Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 4Department of Neurosurgery, Yale University, New Haven, CT, United States |
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Despite potential for more flexible and efficient encoding that better complements receiver geometry, the past decade of work with nonlinear gradients (NLGs) has shown relatively modest improvements on accelerated image quality. In this work we present the first experimental evidence that the previously introduced ROtary Nonlinear Spatial ACquisition (FRONSAC) can notably improve accelerated image quality, both in vitro and in humans. Furthermore, this work introduces and demonstrates a number of robust and flexible attributes of this method, which are crucial to reducing scan times in a clinical setting. |
| S03 | Monday 8:15 - 10:15 | Moderators: Houchun Hu & Elizabeth Hecht |
| 66 | 8:15
|
Arterial-Spin-Labeling (ASL) perfusion MRI predicts cognitive function in elderly individuals: a four-year longitudinal study |
1MR Research, Johns Hopkins University, Baltimore, MD, United States, 2Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, 3Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas, Dallas, TX, United States |
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Identification of biomarkers that can predict cognitive decline is of utmost importance for advance in dementia pharmacotherapy. In this study, cerebral blood flow (CBF) is investigated as a predictor for cognitive decline in a healthy aging population. We found CBF in the frontal lobe to be most predictive for cognitive decline, specifically for episodic memory and in the older population. This suggest that CBF can be used as a biomarker to identify subjects susceptible to cognitive decline, to identify suitable cohorts for clinical trials, and to monitor the effects of pharmacotherapy. |
| 67 | 8:35
|
Measuring human placental blood flow with multi-delay 3D GRASE pseudo-continuous arterial spin labeling at 3 Tesla |
1Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 3Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 4Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States |
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Placenta influences the health of both a woman and her fetus during pregnancy. Maternal blood supply to placenta can be measured non-invasively using arterial spin labeling (ASL). The purpose of this study is to present a multi-delay pseudo-continuous arterial spin labeling (pCASL) combined with a fast 3D inner-volume gradient- and spin-echo (GRASE) imaging technique to simultaneously measure placental blood flow (PBF) and arterial transit time (ATT), and to study PBF and ATT evolution with gestational age during the second trimester. The PBF values were compared with uterine arterial Doppler ultrasound to assess its potential clinical utility. |
| 68 | 8:55
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Reverse double inversion-recovery: improving motion robustness of cardiac T2-weighted dark-blood turbo spin-echo sequence |
1Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States, 2Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, United States |
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The cardiac T2-weighted dark-blood turbo spin-echo (TSE) sequence based on double inversion-recovery (DIR) is subject to motion artifacts due to mismatching of slices from the dark-blood preparation and the TSE readout. Here we propose reverse double inversion-recovery (RDIR), which performs the slice-selective inversion of the DIR preparation in the same cardiac phase as the TSE readout to minimize the slice mismatching. RDIR was evaluated in healthy subjects and patients. Results show that RDIR-TSE achieved a significantly improved image quality in the right ventricle and an improved image quality in the left ventricle compared to the standard DIR-TSE. |
| 69 | 9:15
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Phase-encoded xSPEN: A novel high-resolution volumetric alternative to RARE MRI |
1Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, 2Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, United States |
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We have recently introduced cross-term SPatiotemporal ENcoding (xSPEN), a technique with exceptional resilience to field heterogeneities. This study explores a multi-scan extension of xSPEN, which simultaneously yields ky/kz data containing low and high frequency components as well as transposed low-resolution z/y images, with unique downsampling characteristics. A reconstruction scheme converting this information into high resolution 3D images with fully multiplexed volumetric coverage is introduced. The Results provide a series of high-resolution multiscan xSPEN imaging examples and analyzes their sensitivity vis-a-vis commonly used 2D RARE and multi-slab 3D RARE MRI techniques. |
| 70 | 9:35
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Prospective motion correction with NMR markers using only native sequence elements |
1Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Zurich, Switzerland |
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A new method for tracking active NMR markers is presented. It requires no alterations of the MR sequence and can be used for prospective motion correction (PMC) in brain MRI. The proposed method collects high-frequency information present due to gradient switching from multiple short, temporally separated snippets within one or more TR of the given sequence. A tracking precision on the order of 10µm and 0.01° (RMS) for translational and rotational degrees of freedom is obtained. The method is demonstrated in-vivo with high-resolution 2D T2*-weighted GRE and 3D MPRAGE brain scans. |
| 71 | 9:55
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Learning a Variational Network for Reconstruction of Accelerated MRI Data |
1Institute of Computer Graphics and Vision, Graz University of Technology, Graz, Austria, 2Center for Biomedical Imaging and Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, NYU School of Medicine, New York, NY, United States, 3Safety & Security Department, AIT Austrian Institute of Technology GmbH, Vienna, Austria |
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In this work, we propose variational networks for fast and high-quality reconstruction of accelerated multi-coil MR data. A wide range of experiments and a dedicated user study on clinical patient data show that the proposed variational network reconstructions outperform traditional reconstruction approaches in terms of image quality and residual artifacts. Additionally, variational networks offer high reconstruction speed, which is substantial for the incorporation into clinical workflow. |
| S04 | Monday 8:15 - 10:15 | Moderators: Satoshi Goshima & Ihab Kamel |
| 72 | 8:15
|
View-Sharing Artifact Reduction with Retrospective Compressed Sensing Reconstruction in the Context of Contrast-Enhanced Liver MRI for Hepatocellular Carcinoma (HCC) Screening |
1Radiology, Stanford University, Stanford, CA, United States, 2Electrical Engineering and Radiology, Stanford University, Stanford, CA, United States, 3Radiology, Veteran Affairs Palo Alto Health Care System, Palo Alto, CA, United States |
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View-sharing (VS) increases spatiotemporal resolution in dynamic contrast-enhanced (DCE) MRI by temporally sharing high frequency k-space data across contrast phases. However, this temporal sharing results in respiratory motion occurring in any single phase to propagate artifacts across all phases. Compressed sensing (CS) can eliminate need for VS by recovering missing k-space data from pseudorandom under-sampling, reducing temporal blurring while maintaining spatial resolution. We tested CS versus VS in the setting of DCE MRI for HCC. CS reduced respiratory artifacts, produced images with a more synthetic appearance, and did not result in a difference in lesion detection. |
| 73 | 8:27
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Dynamic Gd-EOB-DTPA enhanced MR imaging of the liver: Value of High Temporal-resolution Images with Parallel imaging and Compressed Sensing |
1Radiology, Seirei Hamamatsu General Hospital, Hamamatsu, Japan, 2Global MR Applications and Workflow, GE Healthcare, Hino, Japan, 3Global MR Applications and Workflow, GE Healthcare, Madison, WI, United States, 4Global MR Applications and Workflow, GE Healthcare, Rochester, MN, United States |
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With ARC and CS, breath-hold dynamic Gd-EOB-DTPA enhanced MR imaging for the liver can be successfully performed with acceptable image quality and lesion recognitions on a clinical 3T magnet. High temporal resolution images with CS-LAVA for dynamic contrast MR study may give us benefits in comparison of Turbo-LAVA with lower temporal resolutions. |
| 74 | 8:39
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Prospective Comparison of Gadoxetic Acid-Enhanced Liver MRI And Contrast-Enhanced CT With Histopathological Correlation For Preoperative Detection Of Colorectal Liver Metastases Following Chemotherapy And Potential Impact On Surgical Plan |
1UHN, Toronto, ON, Canada |
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Complete resection of colorectal cancer liver metastases increases survival and is a recommended therapeutic option. Thus accurate detection of liver metastases is crucial. Many patients receive preoperative chemotherapy which often causes hepatic steatosis and decreases sensitivity of CT in detecting liver metastases. This prospective study with histopathological correlation compared the diagnostic performance of gadoxetic acid Liver MRI in the preoperative detection of liver metastases following chemotherapy including the influence of hepatic steatosis and lesion size. We also evaluated the potential change in the hepatic resection plan due to inclusion of gadoxetic acid MRI compared to CT. |
| 75 | 8:51
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Combined Gadoxetic Acid and Gadobenate Dimeglumine Enhanced Liver MRI for Liver Metastasis Detection: A Parameter Optimization Study |
1Department of Radiology, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, 2Department of Biomedical Engineering, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, 3Department of Medical Physics, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, 4Department of Medicine, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, 5Department of Emergency Medicine, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States |
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The detection of small perivascular metastatic lesions can be challenging with gadoxetic acid-enhanced liver MRI because both, blood vessels and metastases appear hypointense during the hepatobiliary phase. We sought to demonstrate the feasibility of combined gadoxetic acid (GA)/gadobenate dimeglumine (GD) liver MRI for improved lesion detection and optimize the imaging protocol regarding GA-dosing, imaging time after GD-injection and flip angle. Preliminary results show a homogenously enhanced liver and vasculature (“plain-white-liver”) 1-3min after GD-bolus detection with optimal contrast using flip angles of 25-35°. The combined GA/GD protocol has potential to improve the diagnostic performance of hepatobiliary phase liver MRI. |
| 76 | 9:03
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Gadoxetate-enhanced abbreviated MRI is reliable and effective for HCC surveillance in high-risk patients. |
1Liver Imaging Group, University of California San Diego, San Diego, CA, United States, 2Radiology, University of California San Diego, San Diego, CA, United States, 3Gastroenterology and Hepatology, Virginia Mason Medical Center, Seattle, WA, United States, 4Hepatology, University of California San Diego, San Diego, CA, United States |
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Gadoxetate enhanced abbreviated MRI (AMRI) is a simple, rapid acquisition protocol aimed at reducing the cost and increasing the throughput of MRI-based HCC surveillance. Here we analyze 330 consecutive patients with cirrhosis or chronic HBV who underwent at least one screening AMRI. The rate of HCC detected at cross sectional analysis (3.3%) was in line with published incidence of HCC, while the technical failure rate was low (5.8%) despite high prevalence of cirrhosis and ascites. Longitudinal analysis demonstrated high sensitivity, specificity, and negative predictive value in HCC detection, using a composite reference standard. |
| 77 | 9:15
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Volumetric Apparent Diffusion Coefficient Histogram Analysis in Differentiating Intrahepatic Cholangiocarcinoma from Hepatocellular Carcinoma |
1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China |
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Accurate differentiation between intrahepatic cholangiocarcinoma (IHCC) and hepatocellular carcinoma (HCC) is essential for adequate treatment planning. In the present study, non-contrast volumetric ADC histogram analysis was employed to differentiate IHCC (n=33) and HCC (n=98). The results suggested that except the kurtosis and skewness, all the volumetric ADC histogram parameters, were helpful in distinguishing IHCC from HCC. Among all the parameters, 75th percentile ADC was most helpful to distinguish the two diseases. This non-contrast method provides useful information in differentiating IHCC from HCC, it benefits patients who are contraindicate to contrast agents. |
| 78 | 9:27
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Motion Correction of Diffusion-weighted imaging in the analysis of Apparent Diffusion Coefficient for preoperative staging of hepatocellular carcinoma |
1School of Medical Information Engineering, Guangzhou University of Chinese Medicine, Guangzhou, China, 2Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 3Guangzhou Medical University, Guangzhou, China, 4Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China |
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Preoperative tumor staging of hepatocellular carcinoma (HCC) is a critical issue that influences tumor recurrence and patient survival in clinical practice. One of the challenges encountered in DWI of the liver is cardiac motion that can affect the accuracy of ADC measurements, which may inevitably influence the performance of DWI for HCC staging. However, the impact of motion for ADC and HCC staging has not been thoroughly investigated. In this work, we quantitatively investigate the relationship of motion correction, ADC and staging of HCC in order to widen the understanding of applications in DWI for tumor assessment. |
| 79 | 9:39
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Partial velocity-compensated diffusion encoding for combined motion compensation and residual vessel signal suppression in liver DWI |
1Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany, 2Philips Japan, Tokyo, Japan, 3Philips MR Clinical Science, Best, Netherlands, 4Philips Healthcare, Hamburg, Germany |
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Despite its strong clinical significance in lesion detection and tumor staging, liver DWI remains challenged by its strong sensitivity to motion effects. Motion-compensated diffusion encoding schemes have been recently proposed to improve DW liver signal homogeneity especially in the left liver lobe, a region typically affected by cardiac motion. However, motion-compensated diffusion encoding is associated with hyperintense vessel signal even at high b-values, which can obscure lesion detection. The present work proposes a partial velocity-compensated diffusion encoding for combined motion compensation and residual vessel signal suppression in liver DWI. |
| 80
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9:51
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Characterization of Abdominal Neoplasms using a Fast T2 Mapping Radial TSE Technique |
1Electrical and Computer Engineering, University of Arizona, Tucson, AZ, United States, 2Medical Imaging, University of Arizona, Tucson, AZ, United States, 3Biomedical Engineering, University of Arizona, Tucson, AZ, United States |
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Radial turbo spin-echo (RADTSE) based methods have been proposed for quantitative T2 mapping. RADTSE yields high spatio-temporal resolution and allows the reconstruction of co-registered images at multiple TE times from a short acquisition (i.e. a breath hold). We investigate the clinical utility of RADTSE for the quantitative characterization of abdominal neoplasms. |
| 81 | 10:03
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Using Tumor Stiffness as a Potential Biomarker for Predicting Hepatocellular Carcinoma Recurrence |
1Department of Radiology, the Third Affiliated Hospital of Sun Yat-sen University(SYSU), Guangzhou, China, 2Department of Pathology, the Third Affiliated Hospital of Sun Yat-sen University(SYSU), Guangzhou, China, 3Department of Radiology, Mayo Clinic, Rochester, MN, United States, 4Department of Epidemiology and Biostatistics, West China School of Public Health Sichuan University, ChengDu, China |
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Hepatocellular carcinoma (HCC) is a highly aggressive cancer and one of the leading causes of cancer-related deaths around the world. Our preliminary analysis of 78HCCsshowed 3D MRE is a promising, noninvasive technique for predicting the early recurrence of HCCs after hepatic resection. MRE-assessed tumor stiffness correlates with features such as encapsulation, macrovascular invasion, and histological grade. In the future, larger studies will improve our understanding of the relationship between HCC stiffness, invasiveness, and outcome for better allocation of treatment strategies and surveillance follow-up. |
| S06 | Monday 8:15 - 10:15 | Moderators: Irene Vavasour & Frederik Barkhof |
| 82
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8:15
|
Spatial Distribution of Multiple Sclerosis lesions in the Cervical Cord |
1NeuroPoly Lab, Polytechnique Montreal, Montreal, QC, Canada, 2Faculty of Medicine, University of Montreal, Montreal, QC, Canada, 3Department of Radiology and Biomedical Imaging, Zuckerberg San Francisco General Hospital, University of California, San Francisco, CA, United States, 4Montreal Neurological Institute, Montreal, QC, Canada, 5Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China, 6Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 7Department of Radiology, University Hospital of Rennes, Rennes, France, 8University of Rennes, INRIA, CNRS, INSERM, Rennes, France, 9University Rennes, INRIA, CNRS, INSERM, Rennes, France, 10Department of Neurology, University Hospital of Rennes, Rennes, France, 11University Hospital of Montpellier, Montpellier, France, 12CRMBM, CNRS, Aix-Marseille University, Marseille, France, 13CEMEREM, Hôpital de la Timone, AP-HM, Marseille, France, 14Department of Neurology, CHU Timone, APHM, Marseille, France, 15Neuroimaging Research Unit, INSPE, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 16Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 17Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 18Massachusetts General Hospital, Boston, MA, United States, 19Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, 20Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada |
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The study of the spatial distribution of multiple sclerosis (MS) lesions in the cervical spinal cord provides a means to further understand the disease pathophysiology. In this study we involve 358 patients across 7 sites, where cervical lesions were manually segmented. Using Spinal Cord Toolbox, lesion segmentations were registered to a common-space template and voxel-based lesion probability maps (LPMs) were computed across the patient population to assess lesion topography. Results revealed a predominance of lesions in the upper cord (C1-C3) and dorsal column, which confirms prior histopathology work and encourages further study of associations between cervical spine lesion volume and distribution with clinical status. |
| 83 | 8:27
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Spatiotemporal development of spinal cord lesions in a primate model of multiple sclerosis |
1NINDS, National Institutes of Health, bethesda, MD, United States, 2CENIR, Institut du Cerveau et de la Moelle epinière, Paris, France, 3National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, 4National Institute of Neurological Disorders and Stroke, National Institutes of health, Bethesda, MD, United States |
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The spatiotemporal development of spinal cord (SC) lesions in multiple sclerosis (MS) is poorly understood, despite the high prevalence of these lesions and their important contribution to patient disability. In this study, we report for the first time the serial imaging of SC lesions in a nonhuman primate model of MS. The results demonstrated substantial clinical and imaging features shared between this animal model and human MS. In particular, we observed focal and subpial demyelinating lesions that appeared at disease onset and proceeded to affect much of the entire cord over the course of several weeks to months. |
| 84 | 8:39
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Thalamic lesions, thalamic volume and cognitive deficit in secondary progressive MS |
1Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 2Translational Imaging Group (TIG), Centre for Medical Image Computing (CMIC), University College London, London, United Kingdom, 3Leeds Institute of Health Sciences, University of Leeds, Leeds, United Kingdom, 4Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, United Kingdom, 5Edinburgh Clinical Trials Unit, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom, 6Statistics and Epidemiology, Division of Health Sciences, Warwick Medical School, University of Warwick, Warwick, United Kingdom, 7Keele University Medical School, Royal Stoke University Hospital, Stoke-on-Trent, United Kingdom, 8Department of Neurology, Royal Hallamshire Hospital, Sheffield, United Kingdom, 9Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, 10Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 11Brain MRI 3T Research Centre, C. Mondino National Neurological Institute, Pavia, Italy, 12National Institute for Health Research (NIHR), University College London Hospitals (UCLH) Biomedical Research Centre (BRC), London, United Kingdom, 13Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands |
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We investigated the cross-sectional relationships between thalamic lesions (i.e. total thalamic lesion volume), thalamic volume, and cognitive deficit in 55 subjects with secondary progressive multiple sclerosis. We measured: total intracranial volume, T2 lesion volume (T2LV), thalamic volume, thalamic lesions, and symbol digit modalities test (SDMT). Thalamic lesions inversely correlated with thalamic volume and these two variables were independently associated with cognitive deficit as measured by SDMT. After adjusting for T2LV, thalamic volume was the strongest predictor of cognitive deficit. Thalamic lesions may have clinical relevance independent of thalamic volume and will be longitudinally investigated in a bigger sample size. |
| 85 | 8:51
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QSM identifies pro-inflammatory iron-positive MS lesions |
1Radiology, Weill Cornell Medical College, New York, NY, United States, 2Neurology, Yale University, New Haven, CT, United States |
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Multiple sclerosis is an autoimmune disorder whose demyelinated plaques may be connected with elevated iron. We combined quantitative susceptibility mapping (QSM) with histopathological techniques to quantify iron, macrophages/microglia, and pro/anti-inflammatory markers to demonstrate that regions of high susceptibility on QSM correspond to pro-inflammatory iron-positive macrophages/microglia. QSM is therefore a valuable clinical tool to identify smoldering lesions not visible using conventional MRI techniques. |
| 86
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9:03
|
A longitudinal study of lesion evolution in Multiple Sclerosis using multi-contrast 7T MRI |
1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 2Philips Healthcare, Mölndal, Sweden, Mölndal, Sweden, 3Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom |
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We use multi-contrast 7T MRI to evaluate longitudinal changes in white matter tissue properties prior to and after lesion appearance. Four MS patients were scanned 6 times at 6-week intervals, and 20 new lesions were identified on FLAIR images in that period. Of these, 35% showed a hypointense rim and 65% showed no rim in QSM data. Subtle changes in MT, NOE, and QSM relative to NAWM values could be detected 6 weeks prior to the first clinical appearance of new lesions. In future studies, these data will provide insight into specific tissue changes that precede lesion development in MS. |
| 87 | 9:15
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A 3-year follow-up study of enhancing and non-enhancing multiple sclerosis (MS) lesions in MS patients with clinically isolated syndrome (CIS) using a multi-compartment T2 relaxometry (MCT2) model |
1University of Rennes, INRIA, CNRS, INSERM, IRISA UMR 6074, VISAGES ERL U-1228, F-35000 Rennes, France, Rennes, France, 2CRL, Boston Children’s Hospital, Department of Radiology, 300 Longwood Avenue, WB215, Boston, MA 02115, USA, Boston, MA, United States, 3Department of Neurology, Rennes University Hospital, Rennes, France, Rennes, France |
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Obtaining information on condition of tissue microstructures (such as myelin, intra/extra cellular cells, free water) can provide important insights into MS lesions. However, MRI voxels are heterogeneous in terms of tissue microstructure due to the limited imaging resolution owing to existing physical limitations of MRI scanners. Here we evaluated a multi-compartment T2 relaxometry model and then used it to study the evolution of enhancing (USPIO and gadolinium positive) and non-enhancing lesions in 6 MS patients with CIS characteristics over a period 3 years with 7 follow-up scans after baseline. |
| 88 | 9:27
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A multi-parametric study of MS lesions |
1Department of Neuroscience, Brighton & Sussex Medical School, Brighton, United Kingdom, 2Neuroimaging Laboratory, Santa Lucia Foundation IRCCS, Rome, Italy |
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Counter-intuitively, reduced orientation dispersion has been reported in MS lesions, and confirmed by histology. Here we classify lesional tissue based on its orientation dispersion, and we compute a series of indices from from diffusion and magnetization transfer MRI to highlight potential differences in the pathological substrate of lesions with reduced vs increased orientation dispersion. We show that lesions with reduced dispersion are more likely to show extensive demyelination and axonal loss. |
| 89 | 9:39
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The Age effect on Multi-parametric Magnetic Resonance Imaging changes in Multiple Sclerosis lesions |
1Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, 2Signal Processing Laboratory (LTS 5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 3Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 4Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 5Neurology Department and Neuroimaging Laboratory, Basel University Hospital, Basel, Switzerland |
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We assessed the effect of age on the longitudinal evolution of intralesional neurite density and orientation dispersion indices, magnetization transfer ratio and T1 relaxometry in a cohort of relapsing-remitting MS patients. While we observed a decrease of neurite dispersion in lesions and stable neurite density, MTR and qT1, age did not seem to influence those longitudinal changes in MS lesions. |
| 90 | 9:51
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Linking macrostructural and microstructural damage in early MS: a geostatistical and diffusion MRI study |
1Queen Square MS Centre. Neuroinflammation department. UCL Institute of Neurology, University College London, London, United Kingdom, 2Department of Geoinformatics - Z_GIS, Salzburg University, Salzburg, Austria, 3Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, Salzburg, Austria, 4Translational Imaging Group, CMIC, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 5Department of Medical Statistics, London School of Hygiene and Tropical Medicine, University of London, London, United Kingdom, 6Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 7Brain MRI 3T Research Centre, C. Mondino National Neurological Institute, Pavia, Italy |
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Macroscopic white matter (WM) lesion volume has been extensively used to predict disability progression in multiple sclerosis (MS). However, currently used lesion-related metrics fail to capture the complexity of WM-lesion spatial distribution. Here we used geostatistics, an emerging approach to model spatial data projected onto a common coordinate space, to characterise the spatial distributional features of WM lesions of patients with their first MS attack, the clinical relevance of lesion distributional properties and their microstructural correlates, through diffusion MRI. We conclude that WM-lesion spatial distributional features reveal novel aspects of MS pathology, are clinically relevant and possess specific microstructural features. |
| 91 | 10:03
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The relevance of cortical lesions in cortical thinning in multiple sclerosis by ultra-high field MRI |
1Department of Radiology, A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden, 4Department of Radiology, Karolinska University Hospital, Stockholm, Sweden, 5Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States, 6Department of Neurosciences, University of California, San Diego, CA, United States |
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Cortical lesions (CL) and cortical atrophy are frequent in multiple sclerosis (MS) and main determinants of disease progression. The relationship between them is still unknown, mostly due to the low sensitivity of clinical magnetic resonance imaging (MRI) to CL. Disconnection from white matter (WM) lesions has also been proposed as a pathogenic mechanism for cortical MS atrophy. Using 7 Tesla MRI that has shown increased sensitivity to CL than clinical MRI, we showed, in a large MS cohort that WM lesions are the main determinant of cortical thinning. Nevertheless, CL resulted as the main contributors of physical and cognitive disability. |
| W03/04 | Monday 8:15 - 10:15 | Moderators: Ileana Hancu & Savannah Partridge |
| 92
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8:15
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The role of diffusion-weighted MRI in the prediction of response in I-SPY 2 TRIAL |
1Radiology & Biomedical Imaging, UCSF, San Francisco, CA, United States, 2Epidemiology and Biostatistics, UCSF, San Francisco, CA, United States, 3School of Medicine, University of Washington, Seattle, WA, United States, 4Surgery and Radiology, UCSF, San Francisco, CA, United States |
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Diffusion weighted MRI can be used to characterize water mobility and cellularity of tumor by measuring the apparent diffusion coefficient (ADC). Functional tumor volume (FTV) measures size change along the treatment. This study showed that after only 3 weeks of pre-surgery chemotherapy, ADC added value to the logistic regression model of using FTV alone to predict pCR or RCB as outcomes for patients with advanced breast cancer in I-SPY 2 TRIAL. The effect of adding ADC is statistically significant and increase the estimated area under the ROC curve after adjusted for breast cancer subtype categorized by HR and HER2 status. |
| 93 | 8:27
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ACRIN 6702 DWI Trial: The Value of Alternate ADC Metrics Compared to Standard ADC for Decreasing Breast MRI False-Positives |
1Radiology, University of Washington, Seattle, WA, United States, 2ACRIN Biostatistics Center, Brown University, Providence, RI, United States, 3Memorial Sloan Kettering Cancer Center, New York, NY, United States |
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The ACRIN 6702 trial confirmed that standard ADCs from multi b-value DWI acquisition are lower in malignancies than in benign lesions and that application of standard ADCs can eliminate one in five unnecessary biopsies. Secondary analysis from this trial demonstrated that application of alternate ADC metrics, including perfusion insensitive ADCØ and normalized ADC provide no practical benefit over standard ADC for improving conventional DCE-MRI performance. These findings suggest that standard ADC calculations alone are sufficient for improving breast MRI specificity and should be the primary metric included in the next edition of the BI-RADS atlas. |
| 94
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8:39
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DCE-MRI based radiomics signature: a potential biomarker for preoperative prediction of sentinel lymph node metastasis in breast cancer |
1Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, 2Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, China, 3Radiology, Stony Brook Medicine, Stony Brook, NY, United States, 4Computer Science, Stony Brook University, Stony Brook, NY, United States, 5Psychiatry, Stony Brook Medicine, Stony Brook, NY, United States |
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This study is the first to combine DCE-MRI radiomics with clinical information to predict sentinel lymph node (SLN) metastasis in breast cancer. The prediction model was established in a training set, and was further validated in a completely independent validation set, with AUC of 0.898 and negative predictive value of 0.902. This prediction performance surpasses the previous study using T2w and DWI, and is particularly useful for eliminating the unnecessary, invasive SLN biopsy and axillary dissection in patients with negative SLN, offering a step towards precision medicine of breast cancer. |
| 95
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8:51
|
Multi-compartmental sodium quantification in breast using a bilateral dual-tuned proton/sodium coil and multi-pulse excitation scheme at 7T |
1Center for Advanced Imaging Innovation and Research (CAI2R) and Center for Biomedical Imaging, New York, NY, United States, 2The Sackler Institute of Graduate Biomedical Science, New York University School of Medicine, New York, NY, United States |
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Sodium is an important electrolyte in the human body and is a distinct MRI contrast mechanism in breast cancer as it provides insight on cellular viability, ion homeostasis, inflammation, and fluid content. Due to sodium low SNR, intracellular sodium concentration (C1), volume fractions for the intracellular (α1) or extracellular compartments (α2), and fluid (α3) remain largely unexplored. We built a custom bilateral dual-tuned 1H/23Na RF coil and developed a novel fingerprinting-based sodium excitation scheme on a 7T system to enable multi-compartmental sodium quantification in breast. In this work we describe the coil, pulse sequence and preliminary results in one subject. |
| 96
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9:03
|
CEST MRI – a potential tool for breast cancer grade and proliferation rate differentiation |
1High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria, 3Siemens Healthineers, Sydney, Australia |
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I this study, we investigated which CEST contrast changes are characteristic and dominant for breast malignancies. In 18 female patients, we performed DWI, CEST imaging, and T1-CE MRI. Significant differences in MTRasym between G1 and G3 was found (P= 0.007). Between G1 and G2 (P=0.066) as well as between G2 and G3 no difference were observed (P= 0.089). Correlation test demonstrated a strong positive correlation between mean MTRasym measured in region of its maximum and proliferation factor, Ki-67 (r=0.890, P˂0.001). This preliminary results show that CEST-MRI of the breast has a potential to provide information regarding the tumor histological features. |
| 97 | 9:15
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ACRIN 6702 Multisite Breast DWI Trial: Comparison of Site vs. Centralized ADC Measures and Factors Affecting Data Quality |
1Radiology, University of Washington, Seattle, WA, United States, 2ACRIN Biostatistics Center, Brown University, Providence, RI, United States, 3Hematology/Oncology, Vanderbilt University, Nashville, TN, United States, 4Biomedical Engineering, University of Texas, Austin, TX, United States, 5Radiology, University of Michigan, Ann Arbor, MI, United States |
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Diffusion-weighted imaging (DWI) shows potential to improve lesion characterization and diagnostic performance of conventional contrast-enhanced breast MRI. Promising preliminary data from the ACRIN 6702 multisite trial show that DWI can reduce false-positive breast MRIs. Comparison of independently performed site and centrally-measured ADC values showed reasonable agreement, but suggest that further standardization of DWI interpretation and analysis tools across sites could improve diagnostic performance. Results also show more work is needed to address image quality issues and increase utility for measuring ADC values in MRI-detected breast lesions. |
| 98 | 9:27
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Radiomics with magnetic resonance imaging of the breast for early prediction of response to neo-adjuvant chemotherapy in breast cancer patients |
1Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Department of Scientific Computing, Florida State University, Tallahassee, FL, United States, 3Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 4Department of Pathology, Medical University of Vienna, Vienna, Austria |
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Breast cancer patients that achieve |
| 99 | 9:39
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Ultrafast Dynamic Contrast Enhanced MRI of the Breast Using DISCO: Are the Quantitative Parameters Helpful in Differentiating between BI-RADS 4 and 5 Subcentimeter Invasive Carcinomas and Benign Lesions? |
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Lenox Hill Radiology, New York, NY, United States, 3Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 4Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States |
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The quantitative parameters derived from ultrafast dynamic contrast enhanced (UF-DCE) breast MRI using DISCO were analyzed for the assessment of possible utility in the differentiation between subcentimeter invasive carcinoma and benign lesions. Of all these parameters (MS, CER, IAUGC, BAT and Ktrans), BAT was the only parameter that predicted subcentimeter invasive carcinoma. We believe the significantly shorter BAT for subcentimeter invasive carcinomas is congruent with the known pathophysiology of cancer and may reflect its increased vascularity or shunt formation. BAT can be a complementary parameter to conventional steady-state DCE MRI, which could further stratify subcentimeter BI-RADS 4 and 5 lesions. |
| 100 | 9:51
|
Lymph node multi-parametric MRI characteristics of responders and non-responders of neoadjuvant chemotherapy |
1Department of Radiology, Stony Brook University, Stony Brook, NY, United States, 2Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, 3Department of Medicine, Stony Brook University, Stony Brook, NY, United States |
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In the I-SPY 1 breast cancer clinical trial, change in size of the primary in-breast tumor in response to neoadjuvant therapy was a strong predictor of pathologic complete response. In this study, I-SPY 1 MRI lymph node characteristics was studied. Lymph nodes of patients who achieved pathologic complete response after chemotherapy had different characteristics from those who have residual disease in the tumor bed. The percent change of the signal enhancement ratio of each individual lymph node was the best parameter to differentiate between pathologic complete responders versus incomplete or non-responders. |
| 101 | 10:03
|
Evaluation of microstructure heterogeneity from diffusion q-space imaging (QSI), diffusion weighted imaging (DWI) and non-Gaussian diffusion models in whole breast tumour |
1Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom, 2Breast Unit, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 3School of Medicine, University of Aberdeen, Aberdeen, United Kingdom, 4Pathology Department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 5Francis Crick Institute, London, United Kingdom |
||
QSI was compared against conventional DWI and non-Gaussian diffusion models, namely diffusion kurtosis imaging (DKI) and stretched-exponential model (SEM) to evaluate diffusivity heterogeneity for profiling breast tumour cell diversity. We investigated whole breast tumours excised from surgery, with imaging performed overnight on the same day on a clinical system. Asymmetry in diffusivity distribution was quantified as histogram skewness, median and 25th-percentile. Correlation analysis was performed to compare QSI against other models. The skewness of diffusivity distribution derived from QSI was the highest among the models and provided a wider spread of values across cohort, allowing more sensitive clinical applications. |
| W07 | Monday 9:15 - 10:15 | (no CME credit) |
| W08 | Monday 9:15 - 10:15 | (no CME credit) |
Organizers: James Carr, Tim Leiner, Reza Nezafat, Bernd Wintersperger, Jennifer Keegan, Sebastian Kozerke, Winfried Willinek
| Plenary Hall (Paris Room) | Monday 10:30 - 12:15 | Moderators: James Carr & Reza Nezafat |
| 10:30 | ISMRM & ESMRMB Awards |
| 11:15 | Tissue Characterization in the Human Heart |
1Brigham & Women's Hospital, United States |
| 11:35 | Current & Emerging Techniques for Evaluating Cardiac Function |
1Pontificia Universidad Catolica de Chile, Chile |
| 11:55 | Putting it All Altogether: What is the Clinical Impact? |
1University College London |
| 12:15 | Adjournment |
| Plenary Hall (Paris Room) | Monday 12:30 - 13:30 | (no CME credit) |
| Exhibition Hall | Monday 13:45 - 15:45 | (no CME credit) |
| 66 | 13:45
|
Arterial-Spin-Labeling (ASL) perfusion MRI predicts cognitive function in elderly individuals: a four-year longitudinal study |
1MR Research, Johns Hopkins University, Baltimore, MD, United States, 2Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, 3Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas, Dallas, TX, United States |
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Identification of biomarkers that can predict cognitive decline is of utmost importance for advance in dementia pharmacotherapy. In this study, cerebral blood flow (CBF) is investigated as a predictor for cognitive decline in a healthy aging population. We found CBF in the frontal lobe to be most predictive for cognitive decline, specifically for episodic memory and in the older population. This suggest that CBF can be used as a biomarker to identify subjects susceptible to cognitive decline, to identify suitable cohorts for clinical trials, and to monitor the effects of pharmacotherapy. |
| 67 | 14:05
|
Measuring human placental blood flow with multi-delay 3D GRASE pseudo-continuous arterial spin labeling at 3 Tesla |
1Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 3Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 4Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States |
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Placenta influences the health of both a woman and her fetus during pregnancy. Maternal blood supply to placenta can be measured non-invasively using arterial spin labeling (ASL). The purpose of this study is to present a multi-delay pseudo-continuous arterial spin labeling (pCASL) combined with a fast 3D inner-volume gradient- and spin-echo (GRASE) imaging technique to simultaneously measure placental blood flow (PBF) and arterial transit time (ATT), and to study PBF and ATT evolution with gestational age during the second trimester. The PBF values were compared with uterine arterial Doppler ultrasound to assess its potential clinical utility. |
| 68 | 14:25
|
Reverse double inversion-recovery: improving motion robustness of cardiac T2-weighted dark-blood turbo spin-echo sequence |
1Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States, 2Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, United States |
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The cardiac T2-weighted dark-blood turbo spin-echo (TSE) sequence based on double inversion-recovery (DIR) is subject to motion artifacts due to mismatching of slices from the dark-blood preparation and the TSE readout. Here we propose reverse double inversion-recovery (RDIR), which performs the slice-selective inversion of the DIR preparation in the same cardiac phase as the TSE readout to minimize the slice mismatching. RDIR was evaluated in healthy subjects and patients. Results show that RDIR-TSE achieved a significantly improved image quality in the right ventricle and an improved image quality in the left ventricle compared to the standard DIR-TSE. |
| 69 | 14:45
|
Phase-encoded xSPEN: A novel high-resolution volumetric alternative to RARE MRI |
1Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, 2Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, United States |
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We have recently introduced cross-term SPatiotemporal ENcoding (xSPEN), a technique with exceptional resilience to field heterogeneities. This study explores a multi-scan extension of xSPEN, which simultaneously yields ky/kz data containing low and high frequency components as well as transposed low-resolution z/y images, with unique downsampling characteristics. A reconstruction scheme converting this information into high resolution 3D images with fully multiplexed volumetric coverage is introduced. The Results provide a series of high-resolution multiscan xSPEN imaging examples and analyzes their sensitivity vis-a-vis commonly used 2D RARE and multi-slab 3D RARE MRI techniques. |
| 70 | 15:05
|
Prospective motion correction with NMR markers using only native sequence elements |
1Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Zurich, Switzerland |
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A new method for tracking active NMR markers is presented. It requires no alterations of the MR sequence and can be used for prospective motion correction (PMC) in brain MRI. The proposed method collects high-frequency information present due to gradient switching from multiple short, temporally separated snippets within one or more TR of the given sequence. A tracking precision on the order of 10µm and 0.01° (RMS) for translational and rotational degrees of freedom is obtained. The method is demonstrated in-vivo with high-resolution 2D T2*-weighted GRE and 3D MPRAGE brain scans. |
| 71 | 15:25
|
Learning a Variational Network for Reconstruction of Accelerated MRI Data |
1Institute of Computer Graphics and Vision, Graz University of Technology, Graz, Austria, 2Center for Biomedical Imaging and Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, NYU School of Medicine, New York, NY, United States, 3Safety & Security Department, AIT Austrian Institute of Technology GmbH, Vienna, Austria |
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In this work, we propose variational networks for fast and high-quality reconstruction of accelerated multi-coil MR data. A wide range of experiments and a dedicated user study on clinical patient data show that the proposed variational network reconstructions outperform traditional reconstruction approaches in terms of image quality and residual artifacts. Additionally, variational networks offer high reconstruction speed, which is substantial for the incorporation into clinical workflow. |
| Exhibition Hall 1451-1475 | Monday 13:45 - 15:45 | (no CME credit) |
| Exhibition Hall 1476-1508 | Monday 13:45 - 15:45 | (no CME credit) |
| Exhibition Hall | Monday 13:45 - 14:45 | (no CME credit) |
| Exhibition Hall | Monday 13:45 - 14:45 | (no CME credit) |
| W07 | Monday 13:45 - 14:45 | (no CME credit) |
| W08 | Monday 13:45 - 14:45 | (no CME credit) |
Organizers: Muhamed Barakovic, Alessandro Daducci, Tim Dyrby
| S05 | Monday 13:45 - 15:45 | Moderators: Ileana Jelescu & Muhamed Barakovic | (no CME credit) |
13:45
|
Developmental & Computational Properties of Axons | |
14:05
|
Diffusion MRI Techniques for Mapping Axon Diameter: Can We Image Axon Diameter in the Brain? | |
1University College London, United Kingdom |
14:25
|
Axon Diameter Mapping with q-t MRI: Is It the Inner or the Outer? | |
1Radiology, New York University School of Medicine, New York, NY, United States |
14:45
|
The Effect of Axon Diameter on High Temporal Resolution Functional Data | |
15:05
|
Axons, Axons, So Many Axons … What Do We Really Need to Measure? | |
1CUBRIC, School of Psychology, United Kingdom |
15:25
|
Discussion |
Organizers: Pierre-Louis Bazin, Wietske van der Zwaag
| W05/06 | Monday 13:45 - 15:45 | Moderators: Pierre-Louis Bazin & Wietske van der Zwaag | (no CME credit) |
13:45
|
Cerebellar Lobular Structure & Connectional Architecture | |
1Max Planck Institute |
14:15
|
Structural & Functional MRI of the Human Cerebellar Nuclei | |
14:45
|
Insights into Cerebellar Microstructure from Diffusion in Many Dimensions | |
1DRCMR, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark |
15:15
|
Cerebellar Structural & Functional Abnormalities in Multiple Sclerosis | |
Organizers: Sebastian Kozerke, Tim Leiner, Reza Nezafat
| N02 | Monday 13:45 - 15:45 | Moderators: Sebastian Kozerke & Tim Leiner |
13:45
|
Nuts & Bolts of Machine Learning | |
1Imperial College London, United Kingdom |
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This talk will give an overview of machine learning techniques for medical image analysis. We will describe both supervised and supervised machine learning approaches. A particular focus will be on deep learning approaches, including Convolutional Neural Networks (CNN) and how these can be used in cardiovascular MR imaging. We will demonstrate machine learning applications for the fast reconstruction of cardiac MR images from undersampled k-space data, image super-resolution as well segmentation of the cardiovascular anatomy in cine cardiac MRI. |
14:15
|
Role of Machine Learning in Image Acquisition & Reconstruction | |
1Institute of Computer Vision and Graphics, Graz University of Technology, Austria, 2Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States |
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In this educational, we give an overview how deep learning is currently used in static and dynamic MRI reconstruction of undersampled k-space data. While we observe large improvements in terms of image quality and artifact removal for learning-based approaches compared to traditional approaches, we have to consider also several challenges. We will discuss both advantages and challenges using examples of current deep learning-based approaches for reconstruction of undersampled k-space data, focusing on the design of network architectures and loss functions. |
14:45
|
Machine Learning: A Clinical Perspective on CV Disease | |
1Johns Hopkins University, United States |
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Machine learning methods are better suited for meaningful risk prediction in extensively phenotyped large-scale epidemiological studies than traditional methods or risk scores. This strategy could yield insights about specific use of variables for specific event prediction and guiding strategies to prevent cardiovascular disease outcomes. Potentially, these techniques could be applied retrospectively to analyze large data sets for identifying disease mechanisms, and as a means of hypothesis generation, without prior assumptions. |
15:15
|
Will ML Replace Radiologists? | |
In this presentation the current state of the art of Machine Learning in medical image analysis will be discussed and what impact this may have on the role of clinical radiologists. |
15:45
|
Adjournment & Meet the Teachers |
Organizers: Kathryn Fowler, Catherine Hines, Kartik Jhaveri, Lorenzo Mannelli, Valeria Panebianco, Scott Reeder, Reiko Woodhams
| S01 | Monday 13:45 - 15:45 | Moderators: Thomas Hope & Ihab Kamel |
13:45
|
Liver Fat, Iron, & Fibrosis Abbreviated Protocols | |
1Radiology, Mayo Clinic, Rochester, MN, United States |
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With the emergence of non-alcoholic fatty liver disease (NAFLD) as most common chronic liver disease, detection and quantification of liver fat and fibrosis becomes important. Iron overload frequently seen in association with fatty liver and liver fibrosis. Noninvasive quantification of liver fat, iron and fibrosis with MRI is now considered the standard for diagnosis and monitoring. In this presentation, typical clinical scenarios that requires MRI abbreviated protocol for liver fat, iron and fibrosis quantification, candidate sequences and multi-parametric MRI protocols will be discussed. MRI protocols will be illustrated with clinical examples and limitations will be highlighted. |
14:09
|
Liver Screening & Surveillance-HCC | |
1Mount Sinai School of Medicine, United States |
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In this presentation, we will discuss the different scenarios in which AMRI can be used: 1) in the context of cancer screening or diagnosis (liver cancer, liver metastases, prostate cancer); 2) for liver health assessment (fat, fibrosis and iron), 3) in cases of contra-indications to gadolinium contrast. We will discuss the current evidence on the use of AMRI, cost savings, limitations and future directions. |
14:33
|
Screening the High-Risk Pancreas | |
1Radiological Department, General Hospital Ca' Foncello, Treviso, Italy |
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MRI is an imaging method useful in screening high risk patients for pancreatic cancer |
14:57
|
Active Surveillance in Managing Prostate Cancer | |
1Radiology, Johns Hopkins University, Baltimore, MD, United States |
||
Active surveillance (AS) has emerged as an important management strategy to avoid overtreatment of low-risk indolent prostate cancer and MRI of the prostate has been documented to offer high accuracy for the detection and localization of clinically significant cancer with high negative predictive value. The main role of MRI in AS is in patient selection and monitoring with a potential to minimize the invasiveness of follow-up. Abbreviated prostate MRI protocols offer a diagnostic accuracy and cancer detection rates that are equivalent to those of conventional full multiparametric MRIs. |
15:21
|
Breast Cancer Screening | |
1University of Washington, United States |
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Abbreviated breast MRI protocols hold potential to reduce time and overall costs of breast MRI examinations, which could increase accessibility for more widespread screening. A growing number of studies have demonstrated that abbreviated MRI protocols can provide comparable diagnostic accuracy to that of conventional full MRI protocols for breast cancer screening. Current approaches and performance results will be reviewed, along with discussion of future directions. |
15:45
|
Adjournment & Meet the Teachers |
| Power Pitch Theater A - Exhibition Hall | Monday 13:45 - 14:45 | Moderators: Amnon Bar-Shir & Marion Menzel | (no CME credit) |
| 102
|
13:45
|
A novel iterative sparse deconvolution method for multicolor 19F-MRI |
1Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands, 2Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Department of Radiology, Academic Medical Center, Amsterdam, Netherlands |
| 103 | 13:45
|
Multimodal Assessment of Orbital Immune Cell Infiltration and Tissue Remodeling During Development of Graves’ Disease by 1H/19F MRI |
1Experimental Cardiovascular Imaging, Heinrich Heine University, Düsseldorf, Germany, 2University of Essen, Essen, Germany |
| 104 | 13:45
|
Hyperpolarized Xe-129 Imaging of Pluripotent Stem Cell-Derived Alveolar-Like Macrophages in the Lungs: Proof-of-Concept Study Using Superparamagnetic Iron-Oxide Nanoparticles |
1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada |
| 105 | 13:45
|
In Vivo Molecular Imaging of MUC1-Expressing Colorectal Tumors Using Targeted Hyperpolarized Silicon Particles |
1The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 2Rowan University, Glassboro, NJ, United States, 3Rice University, Houston, TX, United States |
| 106
|
13:45
|
Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes |
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and San Francisco, CA, United States, 3Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States |
| 107 | 13:45
|
In-vivo metabolism of co-hyperpolarized [1-13C] pyruvate and [1,3-13C] acetoacetate identifies cytosolic and mitochondrial redox in ischemic perfused hearts |
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4Department of Chemistry, University of Texas at Dallas, Dallas, TX, United States |
| 108 | 13:45
|
Probing perturbed hepatic metabolism in bile-duct-ligated rats with hyperpolarized 13C pyruvate and arginine |
1Laboratory for Functional and Metabolic Imaging, Swiss Federal Institute of Technology, Lausanne (EPFL), Lausanne, Switzerland, 2Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland, 3Centre d'Imagerie Biomedicale (CIBM), Swiss Federal Institute of Technology, Lausanne (EPFL), Lausanne, Switzerland, 4Laboratory for Functional and Metabolic Imaging & Centre d'Imagerie Biomedicale (CIBM), Swiss Federal Institute of Technology, Lausanne (EPFL), Lausanne, Switzerland |
| 109 | 13:45
|
Hollow Manganese-Silicate (HMS) Nanoparticles as a Liver Specific MRI contrast agent |
1Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, 2National Creative Research Initiative Center for Nanospace-confined Chemical Reactions and Department of Chemistry, Pohang University of Science and Technology (POSTECH), Gyeongbuk, Republic of Korea, 3Departments of Health Science and Technology and Medical Device Management and Research, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Seoul, Republic of Korea |
| 110 | 13:45
|
Magnetic Resonance Temperature Imaging for Nanoparticle-Mediated Tumor Photothermal Therapy |
1Medical Imaging Department, First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China, 2Center for Molecular Imaging and Translational Medicine, Xiamen University, Xiamen, China, 3MR Research China, GE Healthcare, Beijing, China |
| 111 | 13:45
|
Amide proton transfer-weighted imaging in meningioma: Prediction of tumor grade, histologic subtype and association with Ki-67 proliferation status |
1Department of Radiology, Zhujiang Hospital of Southern Medical University, Guangzhou, China, 2Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States |
| 112 | 13:45
|
Brown Adipose Tissue Mass Measurement by Z-Spectrum Imaging |
1Radiology, University of Illinois, Chicago, IL, United States, 2Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, 3Center for MR Research, University of Illinois at Chicago, Chicago, IL, United States, 4Research Resource Center, University of Illinois at Chicago, Chicago, IL, United States, 5Radiology, Northwestern University, Chicago, IL, United States, 6Physiology and Biophysics, University of Illinois, Chicago, IL, United States |
| 113 | 13:45
|
Carbon Nanodots as Diamagnetic CEST MRI Contrast Agents for Cell Labeling |
1Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD, United States, 2Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States, 3Kennedy Krieger Institute, Baltimore, MD, United States, 4Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States |
| 114 | 13:45
|
Correlation of tissue pH via 31P-MRSI with MTRasym derived from APT-CEST-MRI in glioblastoma and normal appearing white matter |
1Neuroradiology, University Hospital Frankfurt, Frankfurt am Main, Germany, 2Brain Imaging Center, Goethe University Frankfurt, Frankfurt am Main, Germany |
| 115 | 13:45
|
Imaging vascular inflammation as a marker for T-cell infiltration in preclinical tumor models. |
1Biomedical Imaging, Genentech, South San Francisco, CA, United States, 2Genentech, South San Francisco, CA, United States |
| 116 | 13:45
|
Translational Radiogenomics of Brain Tumors: From Lab-Invesigation to Clinical Application |
1Department of Neurosurgery, Medical Center Freiburg, Freiburg, Germany, 2Department of Nueroradiology, Medical Center Freibrurg, Freibrurg, Germany, 3Medical Center Freiburg, Freiburg, Germany |
| Power Pitch Theater B - Exhibition Hall | Monday 13:45 - 14:45 | Moderators: Pek Lan Khong & Irene Marco-Rius | (no CME credit) |
| 117
|
13:45
|
MRI-only Treatment Planning using Pseudo CT Generation from Deep Learning Approach |
1Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, United States |
| 118
|
13:45
|
Online Super-resolution 4D T2-weighted MRI for MRI-guided Radiotherapy |
1Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom, 2CR-UK Cancer Imaging Centre, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom |
| 119 | 13:45
|
Rapid MR Imaging of Ocular Movement using Shared K-Space Data for Radiotherapy Planning |
1Ophthalmology, Leiden University Medical Center, Leiden, Netherlands, 2Radiology, C.J. Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands |
| 120 | 13:45
|
Visual pathway structure and localisation of tumour-induced disturbance in optic pathway glioma: correlations between diffusion-MRI, visual evoked potentials, and optical coherence tomography |
1UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom, 2Opthalmology Department, Great Ormond Street Children’s Hospital, London, United Kingdom, 3Haematology and Oncology Department, Great Ormond Street Children’s Hospital, London, United Kingdom |
| 121 | 13:45
|
Differentiation between vasogenic edema and infiltrative tumor in patients with high grade gliomas using texture patch based analysis |
1Functional Brain Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 3Department of Chemical Physics, Weizmann Institute, Rehovot, Israel, 4Neuro-Oncology Service, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 5Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel |
| 122
|
13:45
|
Evaluating intratumoral necrosis in gliomas: a multi-modal study of acidosis, cellularity, and vascularity |
1Radiology & Biomedical Imaging, Yale University, New Haven, CT, United States, 2Biomedical Engineering, Yale University, New Haven, CT, United States |
| 123 | 13:45
|
Oxygen enhanced-MRI detects radiotherapy-induced change in hypoxia in xenograft models and lung cancer patients |
1Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom, 2Department of Clinical Oncology, The Christie Hospital NHS Trust, Manchester, United Kingdom, 3Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, United Kingdom, 4Division of Pharmacy and Optometry, University of Manchester, Manchester, United Kingdom, 5Bioxydyn Ltd, Manchester, United Kingdom, 6Department of Radiology, The Christie Hospital NHS Trust, Manchester, United Kingdom |
| 124
|
13:45
|
Assessment of Distant Tumor Stimulation from Liver Radiofrequency Ablation in a Rat Breast Carcinoma Model using Hyperpolarized 13C-Pyruvate MRI |
1Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States |
| 125 | 13:45
|
Late gadolinium enhancement of colorectal liver metastases post-chemotherapy is associated with tumour fibrosis and overall survival post-hepatectomy |
1Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada, 2Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada, 3Department of Pathology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada |
| 126
|
13:45
|
Human Hyperpolarized 13C MR of Liver and Bone Metastases using both EPSI and EPI Acquisitions |
1Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2UC Berkeley - UCSF Graduate Program in Bioengineering, UCSF, San Francisco, CA, United States, 3Department of Medicine, UCSF, San Francisco, CA, United States |
| 127 | 13:45
|
Two Dimensional COSY on Biopsy Distinguishes Indolent From Aggressive Kidney Masses |
1Translational Research Institute, Brisbane, Australia, 2Faculty of Medicine, The University of Queensland, Brisbane, Australia, 3The University of Queensland, Brisbane, Australia, 4Department of Urology, Princess Alexandra Hospital, Brisbane, Australia, 5Aquesta Uropathology, Brisbane, Australia, 6Department of Radiology, Princess Alexandra Hospital, Brisbane, Australia |
| 128 | 13:45
|
In vivo cancer detection and dynamics with magnetic particle imaging |
1Department of Bioengineering, University of California, Berkeley, CA, United States, 2Lodespin Labs, Seattle, WA, United States, 3Department of Material Science and Engineering, University of Washington, Seattle, WA, United States, 4Magnetic Insight, Inc., Alameda, CA, United States, 5Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, United States |
| 129
|
13:45
|
Ferumoxytol-enhanced MRI: Early Results in Solid Organ Masses. |
1Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 2Diagnostic Cardiovascular Imaging Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 3Department of Radiology and Imaging Sciences, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea |
| 130 | 13:45
|
Whole-Body MRI for Metastatic Cancer Detection using T2-Weighted Imaging with Fat and Fluid Suppression |
1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, 3Kidney Cancer Program, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, United States, 4Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States |
| 131
|
13:45
|
Whole body functional and anatomical MRI: Accuracy in staging and interim response monitoring of Childhood and Adolescent Hodgkin’s Lymphoma compared to multimodality conventional imaging |
1Centre for Medical Imaging, University College London, London, United Kingdom, 2Cancer Research UK and UCL Cancer Trial Centre, University College London, London, United Kingdom, 3Institute of Nuclear Medicine, University College London Hospital, London, United Kingdom, 4Department of Paediatric Haemato-oncology, University College London Hospital, London, United Kingdom |
Organizers: Noam Shemesh, Fernando Calamante, Jennifer McNab
| N01 | Monday 13:45 - 15:45 | Moderators: Fernando Calamante & Noam Shemesh |
13:45
|
Microstructure/Diffusion-Mediated MRI Signals | |
1Department of Neuroscience, Medical University of South Carolina, Charleston, SC, United States |
||
Diffusion MRI is highly sensitive to the microstructural properties of biological tissues, such as cellularity and membrane permeability. However, the connections between standard diffusion measures and specific microstructural properties are complex and subtle, making the biological interpretation of changes in diffusion measures associated with disease very challenging. Microstructural modeling has frequently been combined with diffusion MRI to improve interpretability, but the reliability of model predictions is often limited by uncertainties in their underlying assumptions. Here we review these considerations by examining several examples of how microstructure affects commonly employed diffusion measures. |
14:15
|
Application of Microstructure/Diffusion-Mediated Signals to Study Disease | |
1Medical College of Wisconsin, United States |
||
This talk will summarize state-of-the-art techniques to probe tissue microstructure and describe ongoing efforts to understand how the biology of nervous system tissue relates to DWI signal and models. |
| 132 | 14:45
|
Do Non-Gaussian diffusion MRI methods improve the detection or specification of cellular alterations following traumatic brain injury? |
1QMI/NIBIB, National Institutes of Health, Bethesda, MD, United States, 2Henry M. Jackson Foundation, Bethesda, MD, United States, 3NIBIB, National Institutes of Health, Bethesda, MD, United States, 4NICHD, National Institutes of Health, Bethesda, MD, United States, 5APG, Uniformed Services University, Bethesda, MD, United States |
||
Following traumatic brain injury (TBI), numerous microscale cellular alterations appear and evolve with a range of consequences for adverse outcomes and recovery. Diffusion tensor MRI (DTI) has been identified as a potentially sensitive tool for characterizing these changes, but is notably limited in providing specific information about particular cellular alterations and more advanced non-Gaussian frameworks have been developed that may address these limitations. To assess the utility of non-Gaussian modeling for improved detection and specification of TBI-related cellular alterations, we compared DTI, DKI and MAP-MRI in mouse brains following mild TBI and their correspondence to histopathology in the same tissue. |
| 133
|
14:57
|
Histological Validation of in-vivo VERDICT MRI for Prostate using 3D Personalised Moulds |
1Centre for Medical Image Computing, University College London, London, United Kingdom, 2Centre for Medical Imaging, University College London, London, United Kingdom, 3Research Department for Tissue & Energy, University College London, London, United Kingdom, 4Department of Pathology, University College London Hospital, London, United Kingdom, 5Division of Surgery and Interventional Science, University College London, London, United Kingdom |
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VERDICT analysis can successfully distinguish benign from malignant prostate tissue in-vivo showing promising results as a cancer diagnostic tool. However, the accuracy with which model parameters reflect the underlying tissue characteristics is unknown. In this study, we quantitatively compare the intracellular, extracellular-extravascular and vascular volume fractions derived from in-vivo VERDICT MRI against histological measurements from prostatectomies. We use 3D-printed personalised moulds designed from in-vivo MRI that help preserve the orientation and location of the gland and aid histological alignment. Results from the first samples using the 3D mould pipeline show good agreement between in-vivo VERDICT estimates and histology. |
| 134 | 15:09
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Microscopic diffusion anisotropy reveals microstructural heterogeneity of malformations of cortical development associated with epilepsy: A b-tensor encoding study at 7T |
1Clinical Sciences Lund, Medical Radiation Physics, Lund University, Lund, Sweden, 2Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden, 3Random Walk Imaging AB, Lund, Sweden, 4Clinical Sciences Lund, Diagnostic Radiology, Lund University, Lund, Sweden, 5Skane University Hospital, Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden, 6Skane University Hospital, Department of Clinical Sciences Lund, AKVH-Neurology Helsingborg, Lund University, Lund, Sweden |
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Malformations of cortical development are macro- or microscopic abnormalities of the cerebral cortex. Here, we investigated such malformations associated with epilepsy using b-tensor encoding, which is a recently developed technique that permits estimation of microscopic anisotropy also in regions where diffusion is isotropic on the voxel level. Results show a large heterogeneity in microscopic anisotropy between lesions, which we hypothesize represents different levels of axonal content. The characteristics of some types of lesions depended strongly on whether they were associated to other lesions, which could be clinically helpful for indicating hidden sources of epileptic seizures. |
| 135
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15:21
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Investigating microstructural heterogeneity of white matter hyperintensities in Alzheimer’s disease using single-shell 3-tissue constrained spherical deconvolution |
1Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, 2Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia, 3The Australian eHealth Research Centre, CSIRO Health and Biosecurity, Brisbane, Australia, 4Department of Medicine, Austin Health, University of Melbourne, Melbourne, Australia, 5Department of Molecular Imaging & Therapy, Centre for PET, Austin Health, University of Melbourne, Melbourne, Australia |
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White matter hyperintensities (WMH) observed on FLAIR MRI are highly prevalent in Alzheimer’s disease. Although often associated with cognitive decline, such associations are highly variable, likely due to the underlying pathological heterogeneity within these lesions. Here, we explore this potential heterogeneity in vivo in an Alzheimer’s disease cohort, by investigating relative tissue fractions obtained using single-shell 3-tissue constrained spherical deconvolution (SS3T-CSD). We show distinguishable tissue profiles of lesions based on classification as periventricular or deep, and additionally show heterogeneity within lesions, thus highlighting the pitfalls of binary classification of WMH, and the value of investigating their underlying diffusional properties. |
| 136
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15:33
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Neurite Orientation Dispersion and Density Imaging: Added Value in the Detection of Tubers in Patients With Tuberous Sclerosis Complex |
1Department of radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, 2Department of interventional radiology, China Meitan General Hospital, Beijing, China, 3Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 4Department of Neurosurgery, China National Clinical Research Center for Neurological Diseases, Beijing, China |
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The aim of this study was to evaluate the performance of Neurite Orientation Dispersion and Density Imaging (NODDI) in depicting cortical tubers in patients with tuberous sclerosis complex (TSC). By comparing with conventional MRI and DTI, the intracellular volume fraction (ICVF) derived from NODDI showed privilege over both techniques with higher sensitivity and better contrast ratio. Our result has revealed that NODDI was better at detecting microstructural disruption than DTI and conventional MRI sequences with a more reasonable model assumption, and may somehow shed light on the management of epilepsy in TSC patients. |
15:45
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Adjournment & Meet the Teachers |
| N03 | Monday 13:45 - 15:45 | Moderators: Nicola De Zanche & Manushka Vaidya |
| 137 | 13:45
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The MRF Array: an iPRES Coil Array for Accelerated Magnetic Resonance Fingerprinting |
1Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, 2Quality Electrodynamics, Mayfield Heights, OH, United States, 3Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States |
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Magnetic Resonance Fingerprinting (MRF) depends on spatially and temporally incoherent encoding fields for fast quantitative imaging. However the achievable encoding is limited by hardware. The iPRES concept, which adds ΔB0 and B1+ encoding to a receive array, is an excellent candidate for additional encoding for MRF. Here we present preliminary results of a 16 channel iPRES array, referred to as the MRF array. The MRF array uses in-bore power amplifiers to provide vastly increased encoding capabilities while minimizing the cost of additional hardware. Such encoding schemes are expected to allow for acceleration of quantitative imaging techniques such as MRF. |
| 138
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13:57
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Optimization and validation of dipole antenna geometry for body imaging at 10.5T |
1Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 3Biomedical Image Analysis, Eindhoven University of Technology, Eindhoven, Netherlands |
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Body MRI at 10.5T shows potential for improving signal-to-noise ratio compared to |
| 139 | 14:09
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Ultimate intrinsic transmit efficiency for RF shimming |
1Center for Computational and Data-Intensive Science and Engineering (CDISE), Skolkovo Institute of Science and Technology, Moscow, Russian Federation, 2Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, United States, 3Bernard and Irene Schwartz Center for Biomedical Imaging (CBI), Department of Radiology, New York University School of Medicine, New York, NY, United States, 4Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, NY, United States |
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We introduce a new performance metric for RF shimming, the ultimate intrinsic transmit efficiency (UITXE), which provides an absolute reference independent of any particular coil design. We show in simulation that it represents a performance upper bound, which could be approached with finite transmit arrays with an increasing number of coils. In particular, we demonstrated that a 24-channel array could achieve 70% of the UITXE. UITXE could be employed in a straightforward manner in experiments to assess absolute performance of actual arrays and evaluate RF shimming approaches. The associated ideal current patterns could provide new insight for optimal array design. |
| 140 | 14:21
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32-Channel Combined Surface Loop / “Vertical” Loop Tight-Fit Array Provides for Full-Brain Coverage, High Transmit Performance, and SNR Improvement at 9.4T: an Alternative to Surface Loop / Dipole Antenna Combination. |
1Institute of Physics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany, 2High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany |
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Tight-fit human head ultra-high field (UHF,>7T) transceiver (TxRx) surface loop phased arrays improve transmit (Tx)-efficiency in comparison to Tx-only arrays, which are larger to fit receive (Rx)-only arrays inside. A drawback of the TxRx-design is that the number of array elements is restricted by the number of available RF Tx-channels (commonly <16), which limits the Rx-performance. A new 32-element tight-fit human head array, which consists of 18 TxRx-loops and 14 Rx-only vertical loops, was constructed. The array provides for full-brain coverage, ~50% greater B1+, and ~30% greater SNR near the brain center as compared to common Tx-only/ Rx-only (ToRo) array. |
| 141 | 14:33
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Evaluation of Parallel Imaging performance gains with 64 channel receivers at 7 Tesla |
1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2Lifeservices LLC, Minneapolis, MN, United States |
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Evaluation of a 64 channel receiver relative to a 32 channel receiver shows that gains in parallel imaging performance for SMS/MB of 40 to 60% is feasible, such that, highly desirable, single-shot, multislice, whole brain coverage with <1s TR and 1mm or better isotropic resolutions would be achievable at 7T. |
| 142 | 14:45
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Feasibility Study of a Double Resonant (23Na/1H) 8 Channel Rx Head Coil for MRI at 3T |
1Computer Assisted Clinical Medicine,Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany |
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The implementation of 23Na-sodium MRI in the clinical routine is of increasing interest since it can provide valuable information on tissue viability. A design criterion of such double resonant RF setups is to keep the performance of the 1H MRI approximately at the same level as single resonant setups while optimizing the 23Na imaging. This work investigates the feasibility and performance of a double resonant 8 channel receive (Rx) head coil for 1H and 23Na MRI at 3T using EM simulations and a head model. |
| 143 | 14:57
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Whole-body 7T 31P birdcage transmit coil driven by a 35kW RF amplifier with an integrated 30-element 31P receive array and an 8-element 1H transmit/receive array |
1Oxford Centre for Clinical MR Research (OCMR), RDM Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, 2Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sceinces, Bratislava, Slovakia, 3MR Coils BV, Zaltbommel, Netherlands, 4High-Field MR Centre, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, 5Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 6The Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom |
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We describe our experiences implementing a whole-body transmit coil driven by a 35kW RF power amplifier, with a 30-element 31P receive array, and an 8-element 1H transmit/receive array, optimised for cardiac 31P-MRS at 7T. We describe an adaptation to the vendor’s standard SAR monitoring to monitor RF power levels up to the full 35kW output of the RFPA. This new hardware was found to achieve better 31P B1+ and SNR at the depth of the heart than other coils available in our institution. This setup promises to allow the first regionally-resolved, whole-heart 31P-MRSI studies at 7T in the near future. |
| 144 | 15:09
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A 16-channel Rx-only radiofrequency coil for MR spine imaging at 7T |
1Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, Essen, Germany, 2High-Field and Hybrid MR Imaging, University Hospital Essen, Essen, Germany, 3Hamm-Lippstadt University of Applied Sciences, Hamm, Germany, 4University of Applied Science Ruhr West, Mülheim an der Ruhr, Germany, 5Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany |
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In clinical MRI systems operating at 1.5 and 3T, built-in 1-channel radiofrequency (RF) transmit body coils are broadly used in conjunction with local receive RF coils. Recently, a 32-channel Tx/Rx remote body coil has been presented for 7T body MRI. In this work we present an additional 16-channel receive-only spine coil to boost signal-to-noise ratio in comparison to measurements where only the 32-channel Tx/Rx remote body coil is used for reception. The SNR gain is demonstrated in a body-sized phantom. Furthermore, first in-vivo imaging results for 7T MRI of the spine during free-breathing are shown. |
| 145
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15:21
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Higher and more homogeneous B$$$_1^+$$$ for bilateral breast imaging at 7T using a multi-transmit setup with 5 dipole antennas and a 30-loop element receive array |
1Radiology, UMC Utrecht, Utrecht, Netherlands, 2Biomedical Image Analysis, Eindhoven University of Technology, Eindhoven, Netherlands |
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Imaging of the breast at 7 tesla is compromised by the inhomogeneous B1+. To overcome this challenge we explored the use of five fractionated dipole antennas in a multi-transmit system in combination with 30 receiver coils. This coil shows larger SNR, larger FOV and higher and more homogeneous B1 field in the breasts than the currently used breast coil at our institute. The high B1+ and an increased field of view achieved by the fractionated dipole antennas, opens the way to translate routinely used breast imaging protocols from 3T to 7T enabling advanced clinical research. |
| 146 | 15:33
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31-channel receive coil array combined with an 8-channel whole-brain dipole transmit array |
1LIFMET, EPFL, Lausanne, Switzerland, 2Department of Radiology, University of Lausanne, Lausanne, Switzerland, 3Department of Radiology, University of Geneva, Geneva, Switzerland, 4CIBM-AIT, EPFL, Lausanne, Switzerland |
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To increase the parallel imaging performances while keeping high transmit field, the combination of a high-density receive coil array and a tight-fitted whole-brain dipole coil array was investigated. Measured noise correlation matrix, signal-to-noise ratio and g-factor maps were evaluated for the 31-channel receive coil array, and MRI acquisition time could be decreased up to 3.4 times without attenuation in data quality. MR images demonstrated a large spatial coverage, including cerebellum and cerebral cortex, thanks to the whole-brain dipole transmit array while the 31-channel receive coil array provided highly accelerated image acquisition. |
| N04 | Monday 13:45 - 15:45 | Moderators: Catie Chang & Laurentius Huber |
| 147
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13:45
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Imaging Primary Neuronal Activity in the Human Optical Cortex at 1.35Hz |
1Department of Biomedical Engineering, King's College London, London, United Kingdom, 2Brigham and Women's Hospital, Boston, MA, United States, 3Institute of Neuroradiology, University Medical Center Goettingen, Goettingen, Germany, 4MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom |
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In this work we have developed a novel functional MRE system for humans capable of probing stiffness changes in the brain driven by monocular visual stimulation. A continuous visual stimulus was applied at an ON/OFF frequency of 1.35 Hz during a segmented 2D multi-slice MRE sequence with 3D motion encoding operating at 50 Hz vibration frequency. Significant stiffness changes were recorded between ON/OFF during the stimulus experiment that also differed in baseline to control scans (OFF/OFF). Since the BOLD signal is entirely saturated at such high stimulation frequencies, we hypothesize that stiffness changes are due to direct neuronal activities. Data match similar results obtained in mice. |
| 148
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13:57
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Inter-Regional BOLD Latency after Vascular Reactivity Calibration is Correlated to Reaction Time |
1Institute of Biomedical Imaging, National Taiwan University, Taipei, Taiwan, 2Department of Medical Imaging, Taipei Medical University-Shuang Ho Hospital, New Taipei, Taiwan, 3Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, 4Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland |
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Inter-regional BOLD latency between visual and sensimotor cortices were first monitored with fast fMRI (TR=0.1 s) and then calibrated for vascular reactivity using a breath-holding task. Significant delayed response (left: t=4.0, p=0.0019; right: t=6.0, p<0.0001) in the sensorimotor cortex was observed than the visual cortex was detected after removing the vascular confound. Significant correlation between reaction time (428 ± 41ms) and the inter-regional BOLD timing difference (432 ± 149ms) was found within and across subjects. |
| 149
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14:09
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Global responses to microstimulation at 7T and comparison with vibrotactile stimulation |
1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 2Department of Physiology, University of Gothenburg, Gothenburg, Sweden |
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Single unit intra-neural microstimulation (INMS) allows the precise delivery of low-current electrical pulses into human peripheral nerves to stimulate individual afferent nerve fibres. We compare the global pattern of positive and negative BOLD response to INMS with that of perceptually matched vibrotactile stimulation of the skin. INMS and vibrotactile stimulation result in a similar pattern of positive BOLD response, but distinct differences in negative BOLD signals. INMS results in strong negative BOLD response of the DMN, whilst vibrotactile stimulation results in strong ipsilateral negative BOLD response likely to represent active inhibition which is not seen for INMS. |
| 150 | 14:21
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Ultrahigh spatiotemporal-resolution fMRI reveals distinct brain-wide functional networks of different hippocampal subfields |
1BRIC, UNC at Chapel Hill, Chapel Hill, NC, United States, 2Department of Psychology, UNC at Chapel Hill, Chapel Hill, NC, United States |
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The hippocampal formation consists of distinct subfields, which contribute to different aspects of memory function, and exhibit different brain network topologies. However, the brain-wide resting-state functional connectivity of hippocampal subfields in human remains poorly understood mainly due to technical limitations. Previous efforts to identify hippocampal subfield functional networks compromised either spatial resolution, spatial coverage or temporal resolution. We have developed a new approach, named Partition-encoded Simultaneous Multi-slab (PRISM), capable of acquiring ultrahigh isotropic resolution images while maintaining the acceleration capability. Our results of resting-state functional connectivity at 7T reveal distinct brain-wide functional networks associated with different hippocampal subfields. |
| 151 | 14:33
|
High-frequency BOLD responses in human thalamus detected through fast fMRI at 7 Tesla |
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, 2Society of Fellows, Harvard University, Cambridge, MA, United States, 3Radiology, Harvard Medical School, boston, MA, United States, 4Radiology, Harvard Medical School, Boston, MA, United States |
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No current technique can noninvasively localize neural activity in human subcortical structures at subsecond temporal resolution. Recent studies have demonstrated that fast (>0.2 Hz) fMRI responses can be detected in human cortex. We aimed to test whether fast fMRI signals can also be detected in the thalamus. We presented oscillating visual stimuli in order to induce oscillatory neural activity in visual thalamus, and observed large-amplitude fMRI oscillations at 0.5 Hz. We conclude that high-frequency fMRI responses can be detected in thalamus, suggesting fast fMRI has the potential to be used for whole-brain imaging. |
| 152 | 14:45
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Functional organization of visual temporal frequency preference revealed by thalamo-visual correlation |
1National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States |
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Thalamo-visual connections play an important role in the visual system. Little is known about the temporal frequency tuning properties of the thalamo-visual correlation in humans. Here we demonstrated that thalamo-visual correlation is significantly modulated by the temporal frequency of a stimulus. Using correlation with thalamus as an index, human visual cortex is organized along a temporal dimension, with the anterior calcarine preferring low temporal frequencies and posterior calcarine preferring higher temporal frequencies. |
| 153 | 14:57
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Probing temporal information in fast-TR fMRI data during attention modulations |
1CMRR, University of Minnesota, Minneapolis, MN, United States |
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The introduction of fast-TRs has allowed for explorations of temporal features in fMRI data. Further, the ability to concurrently retain relatively high degrees of spatial precision as well as large volume coverage, while also maintaining high SNR efficiency, could provide unprecedented axis to the human brain. In this work we explore the possibility of exploiting the temporal specificity of fMRI using a temporal multi-voxel pattern analysis and high temporal resolution 7T fMRI data during attention modulations. |
| 154 | 15:09
|
Mesoscopic and microscopic imaging of sensory responses in the same animal |
1INSERM U1128, Laboratory of Neurophysiology and New Microscopy, Université Paris Descartes, Paris, France, 2INSERM U979 ‘Wave Physics for Medicine’ Lab, Paris, France, 3NeuroSpin, Bât 145, Commissariat à l'Energie Atomique-Saclay Center, Gif-sur-Yvette, France |
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We developed a chronic olfactory bulb preparation compatible with repetitive imaging of the same mice with BOLD-fMRI (17.2 T), functional ultrasound imaging (fUS) and two-photon laser scanning microscopy. BOLD-fMRI and fUS mesoscopic signals are highly correlated with microscopic vascular and dendritic neuronal signals in response to odour concentrations. Furthermore, minimal odour stimulation reveals that there is no threshold of neuronal activation below which functional hyperemia is not triggered, warranting measurement of blood flow dynamics to detect the lowest levels of brain activation. These data establish the strengths and limits of mesoscopic imaging techniques to report neural activity. |
| 155 | 15:21
|
A transfer function model for local signal propagation in spatiotemporal MR data |
1Weill Cornell Medicine, New York, NY, United States, 2Leibniz Institute for Neurobiology, Magdeburg, Germany |
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In order to understand the sources of dynamic EPI signals under complex stimuli or in the resting state, local signal transfer functions were computed from natural stimulation data sets, and the coherence vector was mapped and color coded analogously to conventional methods for structural connectivity maps. As expected, signal propagation is frequency dependent, whereas high frequencies are caused by cardiovascular pulsations, but low frequencies are less well understood. We conclude that the observed frequency dependence of this local signal transfer model might aid the understanding of the foundation of functional connectivity analysis and the meaning of observed complex patterns such as the resting states. |
| 156
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15:33
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Visceral stimulation triggers high-frequency BOLD responses in the rat brain |
1Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 2Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States, 3Psychological Science, Purdue University, West Lafayette, IN, United States |
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Blood oxygen level dependent (BOLD) fMRI reports brain activity by measuring the vascular response to neural activity mediated through neurovascular coupling. Theoretical modeling of neurovascular coupling suggests its effect as a low-pass filter that cuts off at <0.2Hz. However, recent evidence suggests that BOLD fluctuations may also contain high frequency components. From a different perspective to address the origin of high-frequency BOLD signals in the rat brain, we examined the BOLD and local field potential (LFP) responses to visceral stimulation (electrical stimulation of the stomach or the vagus nerve), in comparison with the corresponding responses to commonly used sensory stimulation, such as forepaw stimulation. We report herein that visceral (forestomach and vagal nerve) stimulation can induce high-frequency (up to 0.8Hz) BOLD responses. The neuronal origins of such responses are different from those underlying the responses to forepaw stimulation, and likely modulate hemodynamic fluctuations through a more rapid mechanism of vascular control. |
| S02 | Monday 13:45 - 15:45 | Moderators: Cristina Cudalbu & Nuno Miguel Pedrosa de Barros |
| 157 | 13:45
|
Automatic Removal of Ghosting Artifacts from MR Spectra using Deep Learning |
1Depts. Radiology and Biomedical Research, University of Bern, Bern, Switzerland |
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Ghosting artifacts in clinical MR spectroscopy are problematic since they superimpose with metabolites and lead to inaccurate quantification. Here, we make use of “Deep Learning” (DL) methods to remove ghosting artifacts in MR spectra of human brain. The DL method was trained on a huge database of simulated spectra with and without ghosting artifacts, which represent complex variants of ghost-ridden spectra, transformed to time-frequency spectrograms. The trained model was tested on simulated and in-vivo spectra. The preliminary results for ghost removal show potential in simulated and in-vivo spectra, but need further refinement and quantitative testing. |
| 158 | 13:57
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A novel structured low-rank framework for ghost removal and denoising of EPSI data |
1Electrical and Computer Engineering, The University of Iowa, Iowa City, IA, United States, 2GE Healthcare, Postdam, Germany, 3GE Global Research, Munich, Germany |
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Spectral interleaving is often used in echoplanar spectroscopic imaging (EPSI) sequences to achieve high spatial and spectral resolution, especially on high field scanners with larger chemical shift dispersion. Unfortunately, a major roadblock is the spurious Nyquist ghost artifacts, resulting from phase errors between interleaves. We introduce a novel framework, that simultaneously capitalizes on annihilation relation between the interleaves introduced by phase relations, as well as a linear predicability of the spectra, to remove the phase errors and to provide spectral denoising of the spectra. In addition, we also exploit on the low-rank structure of the EPSI data to provide additional spatial denoising, which will further improve the signal to noise ratio of the datasets. |
| 159 | 14:09
|
To which extent the Cramér-Rao bound (CRB) is a reliable benchmark in quantitative MRS? |
1AgroResonance - UR370 QuaPA, INRA, Saint Genès Champanelle, France |
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Following MRS data fitting, absolute or relative Cramér-Rao bounds (CRB and rCRB, respectively) are often computed as indices of parameter uncertainties. However, the unknown true values of parameters are required to compute CRB. Here, we studied the effect of substituting the true values by the noisy estimates on the bounds (noted CRB* and rCRB*). We showed by simulations that both CRB* and rCRB* are particularly sensitive to noise. Also, the mode of rCRB* distribution is left-shifted, which leads to a significant false positive risk when rCRB* is thresholded. A threshold not exceeding 20% is recommended to limit this risk. |
| 160
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14:21
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Multi-vendor, multi-site comparison of 1H-MRS PRESS data acquired at 25 research sites |
1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Imaging Institute, Cleveland Clinic Foundation, Cleveland, OH, United States, 4Radiology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, United States, 5Department of Radiology, Haukeland University Hospital, Bergen, Norway, 6Department of Clinical Medicine, University of Bergen, Bergen, Norway, 7Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, 8Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 9Department of Biomedical Engineering, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States, 10Department of Radiology, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan, 11Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway, 12NORMENT – Norwegian Center for Mental Disorders Research, University of Bergen, Bergen, Norway, 13Department of Kinesiology, KU Leuven, Leuven, Belgium, 14REVAL Rehabilitation Research Center, Hasselt University, Diepenbeek, Belgium, 15Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany, 16Brain and Consciousness Research Centre, Taipei Medical University, Taipei, Taiwan, 17School of Health Sciences, Purdue University, West Lafayette, IN, United States, 18Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany, 19Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway, 20Shandong Medical Imaging Research Institute, Shandong University, Jinan, China, 21Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United States, 22Department of Radiology, University of Calgary, Calgary, AB, Canada, 23Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China, 24Department of Neurology, BG University Hospital Bergmannsheil, Bochum, Germany, 25Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom, 26Department of Radiology, Taipei Veterans General Hospital, National Yang-Ming University, School of Medicine, Taipei, Taiwan, 27Department of Radiology, Maastricht University Medical Center, Maastricht, Netherlands, 28Department of Psychiatry, Columbia University, New York, NY, United States, 29New York State Psychiatric Institute, New York, NY, United States, 30GE Healthcare, Calgary, AB, Canada, 31GE Healthcare, Taipei, Taiwan, 32Department of Psychology, University of Washington, Seattle, WA, United States, 33GE Healthcare, Berlin, Germany, 34Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada, 35Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States, 36Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, United States, 37Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada, 38Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 39School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada, 40Leuven Research Institute for Neuroscience & Disease (LIND), KU Leuven, Leuven, Belgium, 41Department of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany, 42Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 43Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States, 44Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany |
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In vivo 1H MR spectroscopy (MRS) provides valuable information regarding various brain disorders. In order to enable further clinical acceptance of MRS, this technique needs to be robust across multiple sites and MR vendors. Therefore, we analyzed data from 288 healthy subjects from 25 research sites across the three major vendors and examined vendor-, site- and participant-related effects on metabolites detected by PRESS 1H-MRS at 3T. Within-site and inter-site coefficients of variation were between 2-16%. Significant effects of vendor were found for Ins/tCr and Glx/tCr. Effect of sites contributed ~30% to total variance of all quantified metabolites. |
| 161 | 14:33
|
Towards in vivo neurochemical profiling of multiple sclerosis with MR spectroscopy at 7 Tesla: Apparent increase in frontal cortex water T2 in aged patients with progressive multiple sclerosis stabilizes in biexponential model constrained by tissue and CSF partial volumes |
1Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, United States, 2Department of Biomedical Engineering, Columbia University School of Engineering and Applied Science, New York, NY, United States, 3Department of Neurology, Yale University School of Medicine, New Haven, CT, United States, 4Mandell Multiple Sclerosis Center, Saint Francis Hospital, Hartford, CT, United States, 5Department of Radiology, Columbia University Medical Center, New York, NY, United States |
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Water is a common internal reference for metabolite quantification by 1H-MRS. We investigate potential influences on water-referenced metabolite quantification by differences in frontal cortex water T2 in individuals with relapsing-remitting, progressive, and no multiple sclerosis. Water T2 differed in monoexponential models, exhibiting highest values in progressive multiple sclerosis only when analyses were not age-controlled. Groupwise T2 did not differ in biexponential models constrained by tissue and CSF partial volumes, suggesting that monoexponential T2 differences reflected disparate proportions of water in tissue and CSF rather than differential behavior within them. Our results suggest stability of water T2 within frontal cortex tissue and CSF with multiple sclerosis and emphasize the superiority of metabolite quantification with group-specific T2 values when voxel composition may differ. |
| 162 | 14:45
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Metabolite Quantification of 1H-MRSI spectra in Multiple Sclerosis: A Machine Learning Approach |
1Department of Computer Science, Technical University of Munich, Munich, Germany, 2Institute for Digital Communications, University of Edinburgh, Edinburgh, Scotland, 3Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland, 4Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, University College London, London, United Kingdom |
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As an alternative to model-based spectral fitting tools, we introduce a machine-learning framework for estimating metabolite concentrations in MR spectra acquired from a homogeneous cohort of 42 patients with Secondary Progressive Multiple Sclerosis. Our framework based on random-forest regression performs a 42-fold cross validation on this dataset which involves (1) learning the spectral features from this cohort; (2) estimating concentrations and calculating relative error over the LCModel estimates. Compared to the LCModel, our method, after training, gives a low estimation error and a 60-fold improvement in estimation speed per patient. |
| 163 | 14:57
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Quantification of Phosphatidylcholine in the gall bladder using 31P MRSI suggest differences in biliary disorders: A Pilot Study. |
1Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria, 2High-field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 3Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria, 4Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, 5Faculty of Healthcare, University of Prešov, Prešov, Slovakia, 6Department of Radiology, General Hospital of Levoča, Levoča, Slovakia, 7Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria |
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This study focuses on quantification of phosphatidylcholine (PtdC) in the gall bladder and investigates concentration differences between biliary pathologies and healthy subjects. Significant different PtdC content was detected in patients suffering from primary sclerosing cholangitis (PSC). Subjects with primary biliary cholangitis (PBC) showed high variances in PtdC concentration. Even though, the PSC and control group are relatively small our results justify for further ongoing studies on this topic. |
| 164 | 15:09
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Neural-network discrimination of cardiac disease from 31P MRS measures of myocardial creatine kinase energy metabolism |
1Radiology, Division of MR Research, Johns Hopkins University, Baltimore, MD, United States, 2Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, United States, 3Radiology, Division of MR Resaerch, Johns Hopkins University, Baltimore, MD, United States |
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Myocardial energy demands are the highest in the body and cardiac metabolism is altered in common diseases. Only phosphorus magnetic resonance spectroscopy (MRS) can measure ATP and creatine-kinase (CK) metabolism, a primary reserve of ATP, noninvasively in the human heart. Here, neural-network analysis is used to test whether the combination of 31P MRS measurements of phosphocreatine and [ATP] concentrations, the CK reaction-rate and its ATP flux, can discriminate cardiac diseases among prior study data from 178 subjects. We find that a three-layer neural-network adequately discriminates diseases without over-training, suggesting that heretofore unidentified differences in CK metabolism may underlie cardiac disease. |
| 165
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15:21
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Enhancing In Vivo Hyperpolarized 13C Chemical Shift Imaging by an Iterative Reconstruction |
1Chemical & Biological Physics, Weizmann Institue, Rehovot, Israel |
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Hyperpolarized 13C magnetic resonance spectroscopic imaging (MRSI) is a powerful metabolic technique, but it’s challenged by a rapid and irreversible decay of the signal that usually compromises its achievable spatial resolution. In this work we explore a way to improve this by utilizing a priori anatomical information derived from 1H MRI. Enhanced HP-MRSI implementations based on Spectroscopy with Linear Algebraic Modeling (SLAM) were thus assayed, to enhance HP-MRSI’s spatial resolution without compromising SNR. 13C experiments were performed in-vivo and pyruvate/lactate images reconstructed for physiological compartments by SLAM; we compare these results to those arising by traditional Fourier analyses. |
| 166
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15:33
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Constrained MRSI Reconstruction Using Water Side Information with a Kernel-Based Method |
1Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Paul C. Lauterbur Research Center for Biomedical Imaging, Institutes of Advanced Technology, Shenzhen, China |
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Reconstruction for MR spectroscopic imaging (MRSI) is a challenging problem where incorporation of spatiospectral prior information is often necessary. While spectral constraints have been effectively utilized in the form of temporal basis functions, spatial constraints are often imposed using spatial regularization. In this work, we present a new kernel-based method to incorporate a priori spatial information, which was motivated by the success of kernel-based methods in machine learning. It provides a new mechanism for constrained image reconstruction, effectively incorporating a priori spatial information. The proposed method has been evaluated using both simulation and in vivo data, producing very impressive results. This new reconstruction scheme can be used to process any MRSI data, especially those from high-resolution MRSI experiments. |
| S03 | Monday 13:45 - 15:45 | Moderators: Nicolas Boulant & S. Johanna Vannesjo |
| 167
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13:45
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On pseudo-concomitant fields caused by gradient coil vibrations |
1Dept. of Radiology, Medical Physics, Medical Center University of Freiburg, Faculty of Medicine, Freiburg, Germany, 2Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan |
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We demonstrate that a negative quadratic phase accrual, which we term a pseudo-concomitant field, is likely to be caused by gradient vibration and has a nearly constant spatial distribution. Accounting for this effect may be of importance for phase-sensitive MR applications utilizing strong gradients, such as flow imaging. |
| 168 | 13:57
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$$$B_{0}$$$-component determination of the gradient system transfer function using standard MR scanner hardware |
1Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany, 2X-Ray and Molecular Imaging Laboratory, Ostbayerische Technische Hochschule Amberg-Weiden, Weiden, Germany, 3Siemens Healthcare GmbH, Erlangen, Germany |
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As a linear and time-invariant (LTI) system, the dynamic gradient system can be described by the system transfer function. While special measurement equipment like field cameras can be used to precisely determine even higher orders of the transfer function, phantom-based approaches were introduced for alternative determination without additional hardware needed. This study reports on phantom-based measurements of B0-components, which resulted in transfer functions with sufficiently high resolution for the characterization of mechanical resonances. |
| 169 | 14:09
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GIRF measurement using a combination of triangular and chirp waveform input functions |
1Philips Research Europe, Hamburg, Germany |
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Gradient-impulse-response-function (GIRF) measurement is a well-established method for MRI gradient-system characterization. Typical GIRF input-functions are triangles or chirps. For triangles, measurements have to be performed with different pulse lengths to get a continuous frequency spectrum due to blind spots in the spectrum, requiring long scan times. In contrast, the spectrum of the chirp waveform covers a large frequency range without blind spots. However, at low frequencies the chirp fails due to a diverging intensity in its spectrum. We interleaved both waveforms and obtained a continuous gradient modulation transfer function (GMTF) spectrum down to low frequencies in short measurement time. |
| 170 | 14:21
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Spatially-selective excitation using a tailored nonlinear ΔB0 pattern generated by an integrated multi-coil ΔB0/Rx array |
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 4Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands, 5Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States |
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Multi-coil ΔB0 shim arrays have recently been used for zoomed imaging of target ROIs in mice, providing improved acquisition efficiency without the high SAR, long RF pulses, and other limitations of conventional selective excitation methods that rely solely on linear gradients. We extend this work to zoomed 3D EPI in humans using an integrated ΔB0/Rx array coil to dynamically switch-on a static, spatially-tailored nonlinear ΔB0 pattern during RF excitation. Proof-of-concept selective excitations of the occipital visual cortex and the peripheral cerebrum are shown, with strong correspondence to the target patterns. Four-fold in-plane undersampled EPI of occipital visual cortex demonstrates the method’s potential for efficient high-resolution neuroimaging. |
| 171 | 14:33
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Improved multi-band RF performance using GRATER-based predistortion |
1Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, 2Electrical Engineering, University of Southern California, Los Angeles, CA, United States |
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The Gradient Reversal Approach to Evaluate RF (GRATER) has been shown to accurately measure small-tip RF pulses in phantoms, without the need for added hardware or sophisticated processing. Imperfect RF production can be measured with GRATER, and RF waveforms can be appropriately predistorted. We demonstrate substantial improvements in multi-band RF performance using this approach. For example, a 0.648 ms, 30º FA, 4- band RF pulse with 2 cm center-to-center spacing and 5 mm slice thickness (desirable for SMS cardiac imaging) excites spurious side-lobes with 10.4% and 3.4% max signal before and after GRATER-based RF predistortion, respectively. |
| 172 | 14:45
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MR Fingerprinting (MRF) incorporating simultaneous detection of RF transmit field and B0 inhomogeneity |
1State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China, 2Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China |
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MR fingerprinting with B1+ and B0 field inhomogeneity detection is proposed with an IR-spoiled GRE based sequence. With this sequence, a 12s/slice acquisition simultaneously provide unbiased T1, T2* maps and B1+, B0 information at isotropic 1mm resolution. |
| 173 | 14:57
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Deep Learning Based Approach for Main and RF Field Maps Estimation in MRI |
1GE Healthcare, Bangalore, India |
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In MRI, automatic estimation of main (B0) and RF (B1) field maps from the scanned images will help daily quality assurance and field corrected reconstruction. In this paper, a novel approach based on deep learning technique is presented to estimate B0 and B1 maps from the scanned images. A modified version of stacked convolutional encoder with random skip connections deep learning network is constructed. Two separate networks are used to estimate B0 and B1 maps individually. The networks are trained and tested with phantom images. The results show that the estimated maps are comparable to the actual field maps. Automatic map estimation based on deep learning approach is the first step towards achieving daily quality assurance and field correction from the regular scanned images. |
| 174 | 15:09
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An empirical $$$B^-_1$$$ Non-uniformity Correction of Phased-Array Coil Images without Measuring Coil Sensitivity |
1Radiology, University of Illinois at Chicago Medical Center, Chicago, IL, United States |
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Radio Frequency (RF) receiving coil arrays improve the signal-to-noise ratio (SNR), and enable partial parallel imaging. However, these benefits often come at the cost of image non-uniformity. $$$B^-_1$$$ non-uniformity correction techniques are confounded by signal that not only varies due to coil induced $$$B^-_1$$$ sensitivity, but also due to true signal variations in proton density, susceptibility, and relaxation rates. Herein, we propose an empirical method that produces a $$$B^-_1$$$ non-uniformity-corrected complex image from the phased-array coil images themselves using minimal assumptions and without measuring the coil sensitivities. This method is validated using MRI of the abdomen, brain, and a homogeneous phantom. |
| 175 | 15:21
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Improved image quality for long readout imaging using piecewise linear field map model |
1Bioengineering Department, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2Beckman Institute, University of Ilinois at Urbana-Champaign, Urban, IL, United States |
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Trajectories such as spiral or EPI enable fast acquisition compared to spin warp imaging. While a spin warp acquisition has a readout of 2-3 ms, a spiral trajectory readout can be as long as 60 ms. The efficiency of the spiral trajectory comes at a cost of image quality through magnetic field inhomogeneity and T2* decay during long readouts. In this work, a signal model with a piecewise linear field map is used to correct for the magnetic field inhomogeneity effects during long imaging readouts . The proposed method shows the ability to correct for resulting image artifacts. |
| 176 | 15:33
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Measuring MRI Gradient Trajectory Dynamics using Simultaneous EEG-FMRI |
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom |
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Simultaneous EEG-FMRI data acquisition provides an opportunity for characterization of magnetic field dynamics during imaging, by leveraging the information contained in the EEG induced gradient artefacts. Using a simple effective loop model, we reduce the complex EEG electrode geometry to small effective loops located at off-isocentre positions, which we use to fit first order (linear in space) models of the magnetic field rate of change. From these, estimates of the actual field dynamics, and trajectory/encoding information can be derived at no cost. In this proof-of-principle, we demonstrate estimation of gradient dynamics during a conventional EPI acquisition using simultaneous EEG recordings. |
| S04 | Monday 13:45 - 15:45 | Moderators: John Detre & Sung-Hong Park |
| 177 | 13:45
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Interleaved qBOLD: Combining Extravascular R2’ and Intravascular R2 Mapping for Improved Estimation of Brain Hemodynamic Parameters |
1Radiology, University of Pennsylvania, Philadelphia, PA, United States |
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In qBOLD, the accuracy of local deoxygenated blood volume (DBV) and hemoglobin oxygen saturation (Yv) maps is impaired because of coupling of these two parameters in the signal model. Here, we introduce an interleaved qBOLD method that combines extravascular R2’ and intravascular R2 mapping in a single pulse sequence. Prior knowledge for DBV and Yv is obtained from the velocity-selective-spin-labeling module in the sequence, subsequently used as priors for qBOLD processing. Data obtained in eight subjects demonstrates significantly improved performance yielding plausible values averaging 60.1±3.3% for Yv and 3.1±0.5% and 2.0±0.4% for DBV in gray and white matter, respectively. |
| 178
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13:57
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Multi-delay arterial spin labeling (ASL) more accurately detects hypoperfusion in Moyamoya disease: comparison with a normative PET/MRI database |
1Radiology, Stanford University, Stanford, CA, United States, 2GE Healthcare, Menlo Park, CA, United States, 3Neurosurgery, Stanford University, Stanford, CA, United States |
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We directly compared multi-delay arterial spin labeling (ASL) and standard ASL measurements of cerebral blood flow (CBF) to simultaneously acquired [15O]-PET scans on hybrid PET/MRI in Moyamoya disease. For these Moyamoya patients (N=15) with extremely long arterial transit times, multi-delay ASL outperforms standard ASL in regional correlation and reduces bias relative to PET. We also constructed a voxelwise, normative CBF database based on healthy controls (N=15) with PET/MRI, and identified regions of hypoperfusion in frontal and parietal regions of patients. Multi-delay ASL is more specific to areas of Moyamoya hypoperfusion (more similar to PET), whereas standard ASL overestimates these areas due to low signal. |
| 179
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14:09
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Cerebral Metabolic Rate of Oxygen (CMRO2) mapping by a joint model of quantitative susceptibility mapping (QSM)-based method and quantitative BOLD (qBOLD) |
1Biomedical Engineering, Cornell University, Ithaca, NY, United States, 2Radiology, Weill Cornell Medical College, New York, NY, United States, 3Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China |
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In this work, we propose a gradient echo (GRE) based measurement of oxygen extraction fraction (OEF) based on a simultaneous modeling of the magnitude (using quantitative BOLD corrected for non-blood tissue susceptibility) and phase (based on QSM), without additional vascular challenges and empirical assumptions. Compared to methods based on QSM only and on qBOLD only, the proposed model provided better CMRO2 contrast between gray and white matter, and more uniform OEF in healthy subjects. |
| 180 | 14:21
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3D MRI Mapping of Whole-Brain Water Permeability with Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS) |
1Radiology, Stony Brook University Hospital, Stony Brook, NY, United States, 2Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States |
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Breakdown of the blood-brain barrier has been hypothesized as a key mechanism leading to neuronal dysfunction that underlies many neurological and psychiatric diseases. Compared with exogenous contrast agents, trans-capillary water permeability may provide a more direct and sensitive assessment of BBB integrity at disease onset and progression. While the current gold standard approach to measure water permeability is O15-H2O PET, its widespread use is limited by availability and cost. Here, we propose a novel MRI-based method, IDEALS, to non-invasively map BBB water permeability with high sensitivity and whole-brain coverage. This method was applied in healthy participants and brain tumor patients. |
| 181
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14:33
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Identify the neurovascular coupling efficacy of long-term depolarization or seizer-like events in the hippocampus with optogenetic single-vessel fMRI |
1High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2University of Tuebingen, Tuebingen, Germany, 3Neurology, Renmin Hospital of Wuhan Universit, Wuhan University, Wuhan, China, 4Graduate Training Centre of Neuroscience, University of Tuebingen, Tuebingen, Germany |
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Optogenetic activation can elicit seizure-like events in the hippocampus of anesthetized rats. However, it remains unclear how the hemodynamic signaling responds to the seizure-like events or long-term depolarization in hippocampus. Here, we applied the multi-model fMRI platform to acquire concurrent single-vessel fMRI and calcium signal upon optogenetic stimulation in the hippocampus. The neurovascular coupling coefficient was significantly lower for the long-term depolarization/seizure-like calcium event than that of normally evoked events. The reduced neurovascular coupling efficacy during seizure-like events indicates the lack of sufficient blood supply under high-energy demand of long-term depolarization, and eventually causes tissue damage. |
| 182 | 14:45
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Black-blood angiography of the lenticulostriate artery at 3T using a high-resolution intracranial vessel wall MR technique: a comparison validation with 7T TOF-MRA |
1State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2The Innovation Center of Excellence on Brain Science, Chinese Academy of Sciences, Beijing, China, 3Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 4University of Chinese Academy of Sciences, Beijing, China, 5Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, 6Xuanwu Hospital, Beijing, China |
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The lenticulostriate artery (LSA) supplies blood to the basal ganglia and its vicinity. Noninvasive imaging of the LSA could be clinically useful to understand mechanisms of microvascular pathology or guide early therapeutic intervention. In this study, we used a recently developed high-resolution intracranial vessel wall MR imaging technique to visualize the LSA in a black-blood (BB) fashion at 3T. Compared to 7T TOF-MRA, this approach can depict the LSA, particularly the stems and proximal segments, with comparable image quality. |
| 183
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14:57
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Periventricular cerebral blood flow: A biomarker for small vessel ischemia |
1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States, 3Siemens Healthineers, Madrid, Spain |
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We evaluated periventricular white matter (PVWM) cerebral blood flow (CBF) as a mechanistically specific biomarker for small vessel ischemia and demonstrated the feasibility of its measurement using state-of-the-art arterial spin labeling. We constructed the PVWM region of interest and demonstrated that mean CBF in PVWM had higher correlation with lesion volumes than global, grey matter, or white matter CBF, even after correction for global CBF, age, and sex. PVWM CBF also showed higher correlation with Trail A and B processing speed than CBF in other regions, or lesion volumes. |
| 184
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15:09
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Quantification of flow hemodynamics using non-contrast enhanced 4-dimensional dynamic magnetic resonance angiography |
1Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States |
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Arterial spin labeling (ASL)-based non-contrast enhanced dynamic MR angiography (NCE-dMRA) can provide not only dynamic flow depiction but also quantitative hemodynamics. According to the indicator dilution theory, we proposed a novel analytical solution for arterial blood flow (aBF) quantification in NCE-dMRA. Compared to the previous truncated singular value decomposition (t-SVD), reliable aBF measures were obtained using the proposed method from both simulation and experimental data. Hemodynamic maps including aBF, arterial blood volume and arterial transit time were successfully generated. Our preliminary patient data suggest that the dynamic flow patterns in conjunction with quantitative hemodynamic may provide complementary information for clinical diagnosis. |
| 185 | 15:21
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Investigation of Intracranial Artery Selective Visualization in Superselective 4D-MR Angiography with Pseudo-Continuous Arterial Spin Labeling Combined with CENTRA-Keyhole and View-sharing (SS-4D-PACK) |
1Philips Japan, Tokyo, Japan, 2Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 3Philips Research, Hamburg, Germany, 4Division of Radiology, Department of Medical Technology, Kyushu University Hospital, Fukuoka, Japan, 5Philips Healthtech, Tokyo, Japan |
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Four dimensional (4D) MR Angiography with Pseudo-Continuous Arterial Spin Labeling (pCASL) combined with CENTRA-Keyhole and View-sharing (4D-PACK) has demonstrated high flow visualization ability in clinical use. In this study, we combined Superselective-pCASL with 4D-PACK (SS-4D-PACK) and investigated artery-selective visualization ability in SS-4D-PACK through comparison with contrast inherent inflow enhanced multi-phase angiography combining vessel-selective arterial spin labeling technique (CINEMA-Select). SS-4D-PACK showed higher vessel selectivity and vessel visualization in peripheral artery compared with CINEMA-Select. |
| 186
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15:33
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Acceleration of Vessel-Selective 4D MR Angiography by pCASL in combination with Acquisition of Control and Labeled Images in the Same Shot (ACTRESS) |
1C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom |
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In the last decade, MR dynamic angiography (4D-MRA) using arterial spin labeling has become an important alternative to contrast-enhanced 4D-MRA, although scan-time is usually much longer than contrast-enhanced 4D-MRA. Among other advantages, it has the attractive possibility to allow for vessel-selective visualization. In this study, we propose an adaptation of ACTRESS (Acquisition of ConTRol and labeled Images in the Same Shot) approach for pCASL to enable vessel-selective 4D-MRA with almost halved scan-time. In an in-vivo study, it was shown that pCASL-ACTRESS approach provided vessel-selective 4D-MRA with comparable image quality to a conventional pCASL-approach, but acquired in approximately half the scan-time. |
| S06 | Monday 13:45 - 15:45 | Moderators: Jürgen Reichenbach & Masaki Fukunaga |
| 187 | 13:45
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Direct Imaging of Diamagnetic Susceptibility of Beta Amyloid Aggregates in Transgenic Mouse Models of Alzheimer’s Disease using Quantitative Susceptibility Mapping MRI |
1University of California Berkeley, Berkeley, CA, United States, 2Duke University School of Medicine, Durham, NC, United States |
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We demonstrated in a phantom that beta amyloid is diamagnetic and can generate strong contrast on susceptibility maps. Based on this, it is further shown both in vivo and ex vivo that magnetic susceptibility mapping could be used to monitor accumulation of amyloid plaques in AD mouse models. Most importantly, the diamagnetic susceptibility map and paramagnetic susceptibility map provided histology-like image contrast for identifying deposition of beta amyloid plaques and iron. |
| 188
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13:57
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Iron-induced relaxation mechanisms in the human substantia nigra: towards quantifying iron load in dopaminergic neurons |
1Faculty of Physics and Earth Sciences, Leipzig University, Leipzig, Germany, 2Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 3Paul Flechsig Institute of Brain Research, Leipzig, Germany, 4Felix Bloch Institute for Solid State Physics, Leipzig University, Leipzig, Germany |
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Pathological iron accumulation in the human brain is a biomarker for neurodegeneration. Several diagnostically promising MR-based methods for in vivo iron quantification were proposed, based on the empirical relationship between R2* and iron concentration. However, these do not account for different chemical forms and cellular distribution of iron. We combined post mortem MRI, advanced quantitative histology and biophysical modeling to develop a generative theory linking obtained iron concentrations to quantitative MR parameters. The impact of nanoscale molecular interaction of water with iron and of iron-rich dopaminergic neurons was quantified in substantia nigra. |
| 189
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14:09
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Accurate and Efficient QSM Reconstruction using Deep Learning |
1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Harvard Medical School, Boston, MA, United States, 3Radiology, Stanford University, Stanford, CA, United States |
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Quantitative Susceptibility Mapping (QSM) is a powerful MRI technique to quantify susceptibility changes and reveal pathology such as multiple sclerosis (MS) lesions and demyelination. QSM reconstruction is very challenging because it requires solving an ill-posed deconvolution and removing the effects of a dipole kernel on tissue phases to obtain susceptibility. To address the limitations of existing QSM reconstruction methods in accuracy, stability and efficiency, an iteration-free data-driven QSM reconstruction is proposed that trains a deep learning model to approximate COSMOS QSM quantification from acquired signals and pre-processed phases. Cross-validated on in-vivo datasets with 15 single direction QSM scans and 3 COSMOS QSM results from 3 healthy subjects, the proposed deep learning method achieves accurate QSM reconstruction, outperforming state-of-the-art methods across various metrics. The deep learning solution is also faster than iterative reconstruction by several orders of magnitude, which enables broader clinical applications. |
| 190
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14:21
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Quantitative susceptibility mapping using deep neural network |
1Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea, 2Department of Radiology, Harvard Medical School, Boston, MA, United States |
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In this study, we designed a deep neural network that functions as dipole deconvolution in QSM reconstruction. For label data, COSMOS reconstructed QSM maps were used so that the network produces ground truth like COSMOS results without streaking artifacts. The performance of our network was superior to conventional QSM results with lower RMSE for multiple head orientation input data. |
| 191
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14:33
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Vertebral Column Quantitative Susceptibility Mapping using Joint Background Field Removal and Dipole Inversion |
1Diagnostic and Interventional Radiology, Technical Univeristy of Munich, Munich, Germany, 2Institute of Medical Engineering, Technical University of Munich, Munich, Germany, 3Philips Research Laboratory, Hamburg, Germany, 4Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, Munich, Germany |
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Quantitative susceptibility mapping (QSM) with joint background field removal and dipole inversion is applied in the spine of osteoporosis patients and healthy volunteers. Preliminary multi-MR-parametric patient results are compared to low-dose CT scans to investigate the feasibility of QSM to qualitatively and quantitatively detect features of diseased tissues and differentiate positive and negative susceptibility sources in comparison to R2*-mapping. |
| 192 | 14:45
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Microscopic susceptibility anisotropy imaging: A clinically viable gradient-echo MRI technique |
1Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 2Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom, 3Institute of Imaging Science, Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States |
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The orientation dependence of the gradient-echo MR signal in brain white matter conflates two principal effects, (i) the susceptibility properties of tissue microenvironments, especially the myelin microstructure, and (ii) the axon orientation distribution with respect to the external magnetic field. This work introduces a clinically feasible MRI method based on gradient-echo and diffusion measurements, which we refer to as microscopic susceptibility anisotropy imaging, that disentangles both effects, hence enabling us to estimate microscopic susceptibility anisotropy unconfounded by fibre crossings and orientation dispersion as well as magnetic field direction. |
| 193 | 14:57
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How should we compare QSM results? A correlation based analysis as an alternative to traditional error metrics |
1Advanced MRI Section, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States |
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During the last QSM Workshop, the results of first “Quantitative Susceptibility Mapping (QSM) Reconstruction Challenge” were presented, which was performed to allow a systematic comparison of various QSM algorithms. One unresolved issue was the fact that the comparison metrics did not properly deal with the effect of smoothing. Here, we propose a comparison method based on pearson correlations, which are calculated over 1D lines throughout the QSM volumes, and show its robustness relative to other metrics under the influence of over-smoothing. |
| 194 | 15:09
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Age- and sex-related spatial patterns of variation in normal brain magnetic susceptibility (QSM) revealed by Blind Source Separation (BSS) and Supervised Machine Learning |
1Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, 2Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, United States, 3MR Research Laboratory, IRCCS, Don Gnocchi Foundation ONLUS, Milan, Italy, 4BairdMS Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States |
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Previous studies using QSM have demonstrated a relatively high inter-subject variation of brain susceptibility. In the present work, we combined a blind source separation technique with a machine learning strategy to disentangle spatial networks of independent variation of brain susceptibility. As a first step toward a better understanding of the underlying causes of variation, we studied their associations with age and sex. The analysis revealed several networks with distinct anatomical features, although the applied analysis technique did not involve any information about anatomy, age, or sex. |
| 195 | 15:21
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Constrained Dipole Inversion for Quantitative Susceptibility Mapping Using a "Kernel+Sparse" Model |
1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Shenzhen, China, 3Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States |
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In quantitative susceptibility mapping (QSM), constrained dipole inversion is often necessary to overcome the ill-posedness of the underlying dipole deconvolution problem. Existing methods achieve this by the use of spatial regularization. In this work, we propose a novel "kernel+sparse" model for constrained dipole inversion. In this model, the kernel term absorbs the prior information by representing the susceptibility as a function of prior features while the sparse term accounts for the localized novel features. The proposed method has been evaluated using both simulated and in vivo data, producing impressive results. This method may prove to be useful for many QSM studies. |
| 196
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15:33
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Sensitivity of Relaxometry and Quantitative Susceptibility Mapping to Microscopic Iron Distribution |
1Radiology, University of Wisconsin - Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 3Medicine, University of Wisconsin - Madison, Madison, WI, United States, 4Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, 5Emergency Medicine, University of Wisconsin - Madison, Madison, WI, United States |
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MRI-based iron quantification enables the non-invasive assessment of tissue iron concentration. MRI relaxation parameters such as R2 and R2* are sensitive to iron concentration, but may depend on the microscopic spatial distribution of iron. Quantitative Susceptibility Mapping (QSM) is a promising iron quantification technique, but its sensitivity to the spatial distribution of iron remains unknown. In this work, we performed simulations and in vitro experiments using whole versus lysed erythrocytes to investigate this sensitivity. Our results suggest that QSM, unlike R2 and R2* relaxometry, is independent of the microscopic distribution of iron. |
| W03/04 | Monday 13:45 - 15:45 | Moderators: Jeff Dunn & Konstantin Momot |
| 197 | 13:45
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Correlations of T1ρ with properties of articular cartilage depend on the spin-lock amplitude and orientation of the sample |
1Department of applied physics, University of Eastern Finland, Kuopio, Finland, 2Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 3Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland |
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Several studies have reported different findings on the correlations of the CW-T1ρ relaxation time in articular cartilage with its different properties. Most studies agree on the sensitivity of CW-T1ρ to cartilage proteoglycans, although reports specifically against this also exist. Furthermore, CW-T1ρ has been connected to the collagen network properties and also correlated with T2 relaxation time. Orientation dependence of CW-T1ρ has been reported, as well as its dependence on the spin-locking amplitude. This study aims to combine all of these aspects in a single study. |
| 198 | 13:57
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Using Multidimensional Data Analysis to Identify Traits of Hip OA |
1UCSF, San Francisco, CA, United States |
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This study aims to use big data analytics and imaging to simultaneously analyze all the combined variables in order to identify biomarkers able to classify the different disease progression of hip OA. 102 subjects and their 184 variables were examined. Big data analytics tool, Topological Data Analysis (TDA), was used to generate hypotheses. Three main groups were identified: healthy control subjects, subjects with radiographic and morphological evidence of OA, and subjects who progressed inconsistently were separated by knee biomechanics. The analysis obtained with TDA proposes new phenotypes of these subjects also shows the potential for further examination. |
| 199
|
14:09
|
T2 Texture Analysis Reveals Potential Cartilage-preserving Effect in Presence of Heterozygous WNT1 Mutation in Human |
1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 2Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, 3Folkhälsan Institute of Genetics and University of Helsinki, Helsinki, Finland, 4Department of Orthopedics, Oulu University Hospital, Oulu, Finland, 5Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland, 6Center for Molecular Medicine, Karolinska Institutet, and Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden |
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Quantitative MRI (qMRI) assessment of tibiofemoral articular cartilage was performed in 13 WNT1 mutation-positive (MP) subjects and 13 mutation-negative (MN) controls. Cartilage thickness, T2 and T1r relaxation times, and texture features contrast, homogeneity and dissimilarity of T2 maps were determined in six regions of interests. Texture features demonstrated an opposing trend with age between the two groups in medial tibiofemoral cartilage, suggesting a possible age-related cartilage preservation in MP subjects. Similar differences were not observed in the other qMRI parameters, suggesting that texture analysis is a more sensitive and accurate tool for quantitative cartilage assessment than mere mean relaxation time measurements. |
| 200 | 14:21
|
Can A Machine Diagnose Knee MR Images? Fully-automated Cartilage Lesion Detection by using Deep Learning |
1Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States |
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This study evaluated a fully-automated cartilage lesion detection system utilizing a deep convolutional neural network (CNN) to segment bone and cartilage followed by a second CNN classification network to detect structural abnormalities within the segmented tissues. The CNN network was trained to detect cartilage lesions within the knee joint using sagittal fat-suppressed T2-weighted fast spin-echo images in 125 subjects. The proposed CNN model achieved high diagnostic accuracy for detecting cartilage lesions with a 0.914 area under curve on receiver operation characteristics analysis. The optimal threshold for sensitivity and specificity of the CNN model was 84.3% and 84.6% respectively. |
| 201 | 14:33
|
Automated Knee Cartilage Segmentation with Very Limited Training Data: Combining Convolutional Neural Networks with Transfer Learning |
1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States, 3LVIS Corporation, Palo Alto, CA, United States, 4Mechanical Engineering, Stanford University, Stanford, CA, United States, 5Bioengineering, Stanford University, Stanford, CA, United States, 6Neurology & Neurological Sciences, Stanford University, Stanford, CA, United States, 7Neurosurgery, Stanford University, Stanford, CA, United States, 8Orthopaedic Surgery, Stanford University, Stanford, CA, United States |
||
Magnetic resonance imaging is commonly used to study osteoarthritis. In most cases, manual cartilage segmentation is required. Recent advances in deep-learning methods have shown promise for automating cartilage segmentation, but they rely on the availability of large training datasets that rarely represent the exact nature or extent of data practically available in routine research studies. The goal of this study was to automate cartilage segmentation in studies with very few training datasets available by creating baseline segmentation knowledge from larger training datasets, followed by creating transfer learning models to adapt this knowledge to the limited datasets utilized in typical study. |
| 202 | 14:45
|
Isotropic 3D T2 mapping of knee cartilage with a novel water excitation technique |
1Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 2Center for Biomedical Imaging (CIBM), Lausanne, Switzerland |
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The goal of this study was to develop an isotropic 3D lipid-insensitive T2 mapping technique of knee cartilage. Therefore we combined an existing isotropic 3D T2-prepared gradient-echo T2 mapping technique (Iso3DGRE) with the novel lipid-insensitive binomial off-resonant RF excitation (LIBRE) pulse. LIBRE pulse optimization was performed through numerical simulations and verified in phantom experiments, yielding complete fat signal nulling using a LIBRE pulse as short as 1 ms. T2 mapping of knee cartilage performed in five healthy volunteers with LIBRE excitation allowed for improved cartilage delineation and precise T2 values compared with normal excitation. |
| 203 | 14:57
|
Accelerating 3D-Biexponential T1ρ Mapping of Cartilage using Compressed Sensing with Different Regularizations |
1Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States |
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Quantitative T1ρ imaging usually requires multiple spin-lock times to obtain T1ρ maps, which makes the acquisition time demanding especially for biexponential models. Compressed Sensing has demonstrated significant acquisition time reduction in MRI. Similar improvements are expected for T1ρ relaxation mapping, given the extensive correlations in the series of images. However, it is not clear which combination of sparsifying transform and regularization function performs best for biexponential T1ρ mapping. Here, we compare five CS approaches: l1-norm of principal component analysis, spatio-temporal finite differences, exponential dictionaries, low rank, and low rank plus sparse. Our preliminary results, with three datasets, suggest that L+S is the most suitable method with least T1ρ estimation error. |
| 204 | 15:09
|
UTE-T2* Shows Deep Cartilage Subsurface Matrix Changes 2 Years After ACL Reconstruction |
1Department of Orthopaedic Surgery, Stanford University, Stanford, CA, United States, 2Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States, 3Department of Radiology, Stanford University, Stanford, CA, United States |
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The purpose of this study is to compare 2-D and 3-D assessments of UTE-T2* maps for evidence of alterations to the subsurface cartilage matrix suggestive of cartilage at risk for early OA 2 years after ACL reconstruction. UTE-T2* values from small 2-D, single slice ROIs correlated to 3-D ROI values that encompassed a larger degree of weight-bearing cartilage. Results indicate that single slice 2-D UTE-T2* mapping may be an efficient means to assess the medial femoral cartilage as an imaging marker of pre-osteoarthritis while 3-D assessments provide additional sensitivity to changes in the tibial plateau. |
| 205 | 15:21
|
Local associations between intervertebral disc T1rho/T2, muscle health, physical activity, and clinical disability using voxel-based relaxometry |
1UCSF/UC Berkeley Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA, United States, 2Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States |
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Region of interest based analysis of intervertebral disc composition in low back pain populations is (1) time-consuming and (2) limited in reproducibility, even more so in patients with advanced degeneration. This study applies voxel-based relaxometry (VBR) to investigate the spatial distributions of T1ρ and T2 in lumbar intervertebral discs, and their association to patient reported outcomes and spinal muscle health. Our results demonstrate the potential to use VBR as a tool to more effectively measure biochemical differences in the intervertebral discs across low back pain subgroups and monitor changes over time. |
| 206 | 15:33
|
Quantitative MRI in early intervertebral disc degeneration: T1rho correlates better than T2 and ADC with biomechanics and matrix content |
1Orthopedic Surgery, Academic Medical Center, Amsterdam, Netherlands, 2Orthopedic Surgery, VU University Medical Center, Amsterdam, Netherlands, 3Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands, 4Plastic, Reconstructive and Hand Surgery, VU University Medical Center, Amsterdam, Netherlands, 5Oral and Maxillofacial Surgery, VU University Medical Center, Amsterdam, Netherlands, 6Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands |
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We correlated quantitative T2, T1rho and Apparent Diffusion Coefficient (ADC) values to disc mechanical behavior and gold standard early DDD markers in a graded degenerated lumbar IVD caprine model to assess their potential for early DDD detection. T1rho nucleus values correlate better than T2 and ADC with biomechanical, histological, and GAG changes. |
| W08 | Monday 14:45 - 15:45 | (no CME credit) |
| Exhibition Hall 1509-1553 | Monday 16:15 - 18:15 | (no CME credit) |
| Exhibition Hall | Monday 16:15 - 17:15 | (no CME credit) |
| Exhibition Hall | Monday 16:15 - 17:15 | (no CME credit) |
| W07 | Monday 16:15 - 17:15 | (no CME credit) |
| W08 | Monday 16:15 - 17:15 | (no CME credit) |
Organizers: Peter Caravan, Ira Krefting
| N01 | Monday 16:15 - 18:15 | Moderators: Tim Leiner | (no CME credit) |
16:15
|
State of the Art on Gd Deposition: Science, Clinical & Regulatory Reaction | |
16:30
|
What Do We Still Need to Know About GBCAs? A Roadmap for Further Studies | |
1FDA |
16:45
|
Q & A |
16:55
|
Can Contrast-Enhanced MR Be Replaced? Non-Contrast Methods, Ultra-Low-Dose Contrast & Where Contrast Is Essential | |
1Massachusetts General Hospital, United States |
17:10
|
Gadolinium-Based Contrast Agents: State of the Art & Future Directions | |
1University of Torino, Italy |
17:25
|
Rust Never Sleeps: Iron as an Alternative to Gadolinium for Contrast-Enhanced Imaging | |
1Oregon Health Sciences University, United States |
17:40
|
Metal-Free Contrast Agents | |
17:55
|
Q & A |
Organizers: Shella Keilholz, Hanbing Lu
| N02 | Monday 16:15 - 18:15 | Moderators: Shella Keilholz | (no CME credit) |
16:15
|
Infraslow Electrical Activity & BOLD Oscillations | |
1Neuroscience, Emory University, Atlanta, GA, United States |
16:39
|
Contribution of Vigilance Fluctuations to Resting-State fMRI | |
1NINDS, NIH |
17:03
|
Electrophysiological Brain Networks: Insights from Magnetoencephalography (MEG) | |
1University of Nottingham |
17:27
|
Global Cerebral Glucose Metabolism & the Global Signal from Resting-State fMRI | |
17:51
|
Panel Discussion |
Organizers: Marcus Alley, Bernd Jung
| S01 | Monday 16:15 - 18:15 | Moderators: Joseph Cheng & Bernd Jung |
16:15
|
Spin Gymnastics 1 & 2 | |
1University of Wisconsin - Madison, United States |
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This educational lecture will provide a general overview of the basic physics of MRI. A broad range of topics will be covered, including magnetization and signal generation, relaxation of magnetization, the spin echo phenomenon, spatial encoding of signal, and a very brief introduction to the concept of k-space. Several of the topics will be introduced in this lecture and will be further elucidated by other presenters in this course. |
17:45
|
Image Quality | |
1Division of Radiological Physics, Dept. of Radiology, University Hospital Basel, Basel, Switzerland, 2Dept. of Biomedical Engineering, University of Basel, Basel, Switzerland |
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This educational talk presents an overview of key aspects influencing and quantitatively depicting image quality. Several examples for the different types of image quality aspects are given. The importance of signal-to-noise ratio (SNR) and the "triangle of death" for image quality in MRI is discussed in particular. |
18:15
|
Adjournment & Meet the Teachers |
Organizers: Eric Chang, Garry Gold, Edwin Oei, Philip Robinson
| W05/06 | Monday 16:15 - 18:15 | Moderators: Xiaojuan Li & Ashley Williams |
16:15
|
Relaxation | |
1Oulu University Hospital, Finland |
16:40
|
Standardization, Phantoms | |
1NIST, United States |
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This talk will review how to design a phantom for MSK applications, how to develop standardization across platforms, and considerations for reproducibility and reliability studies. |
17:05
|
Image Processing, Machine Learning and Multimodal Data Analysis | |
1University of California, San Francisco, United States |
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In this lecture, we provide an overview on the potential of coupling of cutting edge technologies in quantitative MRI, deep learning and big data analytics fields. The main goal is to show how those techniques can be applied to discover latent feature able to accurately characterize disease status and predict progression. The data-driven extraction of features from relaxation maps and multidimensional analysis of data from various sources can exploit the real potential of quantitative MRI technique, to date still hampered by tedious and time-consuming manual image post-processing pipelines; and deeply underused due to the handcrafting of too simplistic image representations. |
17:30
|
Common Pitfalls in Quantitative MSK MRI | |
1University of Saskatchewan, Canada |
17:55
|
Panel Discussion |
18:20
|
Adjournment & Meet the Teachers |
| Power Pitch Theater A - Exhibition Hall | Monday 16:15 - 17:15 | Moderators: Oliver Bieri & Mark Chiew | (no CME credit) |
| 207 | 16:15
|
Maxwell-compensated waveform design for asymmetric diffusion encoding |
1Clinical Sciences, Lund, Lund University, Lund, Sweden, 2Random Walk Imaging AB, Lund, Sweden |
| 208 | 16:15
|
Spin And Field Echo (SAFE) dynamic field correction in 3T fetal EPI |
1King's College London, London, United Kingdom, 2Physikalisch-Technische Bundesanstalt, Braunschweigh and Berlin, Germany |
| 209
|
16:15
|
Self-Gated and Real-time Simultaneous Multi-Slice Cardiac MRI from the Same Acquisition |
1Intistut für Diagnostische und Interventionelle Radiologie, University Medical Center Göttingen, Göttingen, Germany, 2Partner Site Göttingen, German Centre for Cardiovascular Research (DZHK), Göttingen, Germany |
| 210
|
16:15
|
Phase Encoded xSPEN: A High-Definition Approach to Volumetric MRI with Unusually High Acceleration Factors |
1Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, 2Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, United States |
| 211
|
16:15
|
Accelerated T2-Weighted Imaging of the Abdomen with Self-Calibrating Wave-Encoded 3D Fast Spin Echo Sequences |
1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Global MR Applications and Workflow, GE Healthcare, Menlo Park, CA, United States, 3Radiology, Stanford University, Stanford, CA, United States |
| 212
|
16:15
|
Tilted-CAIPI for Highly Accelerated Distortion-Free EPI with Point Spread Function (PSF) Encoding |
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 3Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States |
| 213
|
16:15
|
Silent MRF : Quantitative scan with reduced noise using the Magnetic Resonance Fingerprinting (MRF) framework |
1Radiology, Case Western Reserve University, Cleveland, OH, United States |
| 214 | 16:15
|
Focused, High-Resolution, Distortion-Free Diffusion Imaging |
1Department of Radiology, Mayo Clinic, Rochester, MN, United States |
| 215
|
16:15
|
DP-TSE MRF: Rapid and Accurate T2 and ADC Quantification Using Diffusion-Prepared Turbo Spin-echo Magnetic Resonance Fingerprinting |
1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 2Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, 3State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China |
| 216 | 16:15
|
Shuttered EPI Brain Imaging at 7 Tesla |
1Department of Radiology, Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 2Department of Radiology, A.A. Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA, United States, 3Department of Biomedical Engineering, Vanderbilt University Institute of Imaging Science, Vanderbilt Univserity, Nashville, TN, United States |
| 217
|
16:15
|
Echo Planar Time-resolved Imaging (EPTI) |
1A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, 3Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China |
| 218 | 16:15
|
TOPPE: A framework for rapid prototyping of MR pulse sequences |
1Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States |
| 219
|
16:15
|
Time-optimal control based RF pulse design under gradient imperfections |
1Institute of Medical Engineering, Graz University of Technology, Graz, Austria, 2Institute for Mathematics and Scientific Computing, University of Graz, Graz, Austria, 3Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 4Johann Radon Institute for Computational and Applied Mathematics (RICAM), Austrian Academy of Sciences, Linz, Austria |
| 220
|
16:15
|
Fast multi-component T1 and T2 correlation measurements using steady-state free precession |
1Magnetic Resonance and X-ray Imaging Department, Fraunhofer Development Center X-ray Technology (EZRT), Würzburg, Germany, 2Experimental Physics 5, University of Würzburg, Würzburg, Germany |
| 221 | 16:15
|
MEG-Navigators for Motion Detection and Quality Assurance in MR Elastography |
1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland |
| Power Pitch Theater B - Exhibition Hall | Monday 16:15 - 17:15 | Moderators: Xiaoqi Huang & Fei Li | (no CME credit) |
| 222 | 16:15
|
Iron-related gene expression associated with magnetic susceptibility reductions: Application to the pathophysiology of a movement disorder population |
1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Department of Psychiatry, Hannover Medical School, Hannover, Germany, 3Siemens Healthcare, Erlangen, Germany, 4Douglas Mental Health Institute, McGill University, Montreal, QC, Canada, 5Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States |
| 223
|
16:15
|
Multimodal ASL/PET/mRNA-expression analysis reveals CBF changes after single dose of antipsychotics depend on dopamine D2 receptor density profiles. |
1Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom, 2Imanova Ltd., Centre for Imaging Sciences, Hammersmith Hospital, London, United Kingdom, 3Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK, London, United Kingdom, 4Translational Medicine Neuroscience and Biomarkers, F. Hoffmann-La Roche Ltd, Basel, Switzerland, 5Department of Experimental and Clinical Medical Sciences, University of Udine, Udine, Italy, 6Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy |
| 224 | 16:15
|
Impaired modulation of hippocampal glutamate during memory consolidation in schizophrenia: Evidence from ¹H fMRS |
1Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States |
| 225
|
16:15
|
N-acetyl-cysteine supplementation improves functional connectivity in the cingulate cortex in early psychosis |
1Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, 2Dutch connectome lab, University Medical Center (UMC), Utrecht, Netherlands, 3Service of General Psychiatry and Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland, 4Department of psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland |
| 226
|
16:15
|
Altered Brain Development in Infants and Young Children with at Risk Genetics for Psychiatric Dysfunction |
1Brown University Warren Alpert School of Medicine, Providence, RI, United States, 2Memorial Hospital, Brown University, Providence, RI, United States, 3Waisman Center, University of Wisconsin, Madison, WI, United States, 4Center for Neuroimaging, King's College, London, United Kingdom |
| 227
|
16:15
|
7T MRS in First Episode Psychosis: Neurotransmitter Deficits and Neuronal Impairment |
1Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, United States |
| 228 | 16:15
|
A DTI connectome and machine learning approach to predict symptom improvement in depressed adolescents with cognitive-behavioral therapy (CBT) |
1University of California, San Francisco, San Francisco, CA, United States, 2Florida State University, Tallahassee, FL, United States, 3Umea University, Umea, Sweden |
| 229 | 16:15
|
Neural network classification of ADHD based on white matter connectograms derived from diffusion spectrum imaging |
1Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, 2Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan, 3Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan, 4Molecular Imaging Center, National Taiwan University, Taipei, Taiwan |
| 230 | 16:15
|
Hippocampal-subfield Specific Connectivity Alterations in Major Depressive Disorder Patients at 7 Tesla |
1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States |
| 231 | 16:15
|
Reduced Local Segregation in Single-Subject Grey Matter Networks in Adult PTSD |
1HMRRC, West China Hospital, Chengdu, China, China, 2Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom, London, United Kingdom, 3uaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan, Chengdu, China |
| 232 | 16:15
|
Sertraline treatment modulates salience connectivity in major depressive disorder |
1Brain and Consciousness Research Center, Taipei Medical University, Taipei, Taiwan, 2GE Healthcare, Taipei, Taiwan, 3National Yang-Ming University, Taipei, Taiwan, 4Department of Radiology, National Defense Medical Center, Taipei, Taiwan |
| 234 | 16:15
|
Abnormal Perfusion and Perfusion fluctuation in Bipolar Disorder measured by ASL |
1State University of New York at Binghamton, BINGHAMTON, NY, United States, 2Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States, 3Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States |
| 235 | 16:15
|
Elevated brain iron in cocaine addiction as indexed by magnetic field correlation imaging |
1Neuroscience, Medical University of South Carolina, Charleston, SC, United States, 2Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States, 3Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States |
| 236 | 16:15
|
Deletion of CRTC1 is associated with strong neuroenergetic dysfunctions in a mouse model of mood disorders. |
1Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2Animal Imaging and Technology Core (AIT), Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne., Lausanne, Switzerland, 3Center for Psychiatric Neuroscience (CNP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, 4Department of Radiology, University of Geneva, Geneva, Switzerland, 5Department of Radiology, University of Lausanne, Lausanne, Switzerland |
Organizers: Kathryn Fowler
| S02 | Monday 16:15 - 18:15 | Moderators: Sudhakar Venkatesh & Ralph Sinkus |
16:15
|
Measuring Liver Function-Technical Aspects | |
1Leeds Imaging Biomarkers Group, University of Leeds, United Kingdom |
||
This talk will provide a broad introduction of MRI methods to measure the function of liver parenchyma, with more in-depth treatment of Dynamic Gadoxetate-Enhanced MRI for the quantification of hepatocellular transporter function. We will also cover some basic facts about the liver, review competing non-MRI techniques for assessing liver function, and present examples of applications in basic science, drug development and clinical practice. |
| 237 | 16:45
|
Clinical Assessment of Nonalcoholic Steatohepatitis (NASH) with Multi-parametric MRI |
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Gastroenterology, Mayo Clinic, Rochester, MN, United States, 3GE Healthcare, Waukesha, WI, United States, 4GE Healthcare, Menlo Park, CA, United States, 5GE Healthcare, Silver Spring, MD, United States, 6Anatomic Pathology, Mayo Clinic, Rochester, MN, United States, 7Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States |
||
In 27 clinical patients, we performed multi-parametric hepatic MRI, including proton density fat fraction with R2* correction, MR Elastography (MRE), and T1 mapping to characterize nonalcoholic steatohepatitis (NASH). Fat fraction and multiple MRE-assessed mechanical parameters successfully diagnosed NASH (p<0.05 for all). Diagnostic abilities of all parameters were evaluated based on steatosis, inflammation and ballooning scores respectively. Spearman correlations were used to analyze the correlations between imaging parameters. We found that T1 relaxation time had a significantly positive correlation (ρ=0.72, p=0.0005) with fat fraction. In summary, multi-parametric MRI is a potential imaging surrogate for diagnosing NASH. |
| 238 | 16:57
|
Implementation of T1 Mapping in Routine Clinical MR Liver Exam For The Detection of Hepatic Fibrosis and Portal Hypertension in Hepatitis C Patients |
1Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, United States, 2Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, United States, 3Interventional Radiology, Clinical Center, NIH, Bethesda, MD, United States |
||
Application of two short single breath hold T1 mapping shMOLLI technique (before and after Gadolinium injection) to a routine clinical MRI liver exam can detect both severe fibrosis and portal hypertension in Hepatitis C. The technique was prospectively validated in 29 patients with reference standard clinical methods including liver biopsy and direct portal venous pressure measurements. Utilizing this method would allow for a comprehensive anatomic and functional MRI study in a single session without substantial prolongation of scan time, thereby, allow non-invasive monitoring of therapy and/or progression of disease. |
17:09
|
Prognosis & Prediction for Liver Tumors | |
1Johns Hopkins Hospital, United States |
| 239
|
17:39
|
Preoperative Remnant Liver Function Evaluation using a Clinical-Available Gd-EOB-DTPA-Enhanced MR Imaging Protocol in HCC Patients |
1Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing, China, 2Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, China, 3Beijing Tsinghua Changgung Hospital, School of Medicine, Tsinghua University, Beijing, China |
||
Accurate evaluating of remnant liver function preoperatively is important for surgery planning and reducing posthepatectomy liver failure (PHLF) rate in hepatocellular carcinoma (HCC) patients. In this study, an accurate remnant liver function evaluation method was proposed using a clinical-available MR imaging protocol. The remnant liver function measured by the proposed method showed significant difference between the patients with and without PHLF. More importantly, ROC analysis showed the proposed method has a larger AUC than remnant liver volume and ICG based parameters in predicting PHLF. |
| 240
|
17:51
|
MRI texture features as predictors of histopathologic and genomic characteristics of hepatocellular carcinoma. |
1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Department of Medicine/Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, United States |
||
The goal of this study was to assess the diagnostic value of texture features measured with MRI compared to qualitative imaging traits for the prediction of histopathologic and genomic characteristics of hepatocellular carcinoma (HCC) lesions. Texture features exhibited additional, complementary correlations with histopathology and genomics compared to qualitative imaging traits, including association with microvascular invasion and expression of immunotherapy target CTLA4. These promising results warrant further investigation of texture features as predictors of histopathologic and genomics measurements in HCC. |
| 241 | 18:03
|
Presence of non-hypervacular hypointense nodule on hepatobiliary phase of gadoxetic acid enhanced MR: Risk of tumor recurrence after curative treatment for small single nodular HCC and guidance for selection of treatment option |
1Radiology, Seoul National University Hospital, Seoul, Republic of Korea |
||
Presence of non-hypervascular hypointense nodule on hepatobiliary phase of gadoxetic acid enhanced liver MR can stratify the risk of tumor recurrence after curative treatment for small single nodular HCC equal to or less than 3cm. |
18:15
|
Adjournment & Meet the Teachers |
| N03 | Monday 16:15 - 18:15 | Moderators: Julia Velikina & Sajan Goud Lingala |
| 242
|
16:15
|
3D-Patch-Based Low-Rank Reconstruction (PROST) for Highly-Accelerated CMRA Acquisition |
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom |
||
Free-breathing coronary MR angiography (CMRA) has shown great potential to visualize coronary stenosis. Three-dimensional (3D) CMRA, however, remains time consuming because a large amount of data is needed to accurately visualize all major coronary arteries. Scan acceleration using compressed sensing (CS) reconstruction has successfully been applied to coronary artery imaging. For high acceleration factors, however, CS-based techniques suffer from residual aliasing artifacts which compromise the diagnostic value of the reconstructed image. We propose a new 3D-patch-based reconstruction that exploits the complex 3D anatomy of the coronary arteries in an effective low-rank framework, which combined with 100% respiratory efficiency enables high-quality isotropic Cartesian CMRA images in ~3 mins. |
| 243 | 16:27
|
Kernel low-rank regularization: an efficient approach for recovering dynamic images on a manifold |
1University of Iowa, Iowa City, IA, United States |
||
The main focus of this abstract is to introduce an efficient algorithm to recover a free breathing and ungated cardiac MR image series from highly undersampled measurements. The main contributions are (i) a kernel low-rank algorithm to estimate the manifold structure (Laplacian) from noisy navigator signals, (ii) a fast algorithm that uses the Laplacian basis functions to recover the data from highly undersampled measurements. The utility of the algorithm is demonstrated on radial acquisitions from patients with congenital heart disease; the results show that the framework is a promising alternative to self-gating methods. |
| 244 | 16:39
|
Gradient-Controlled Local Larmor Adjustment (GC-LOLA) for CAIPIRINHA-Accelerated bSSFP Imaging with Improved Banding Behavior |
1The Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, 2Department for Diagnostic and Interventional Radiology, University of Würzburg, Würzburg, Germany, 3Siemens Healthcare, Erlangen, Germany |
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The simultaneous multi-slice (SMS) imaging technique CAIPIRINHA has proven to be highly efficient for extending the slice coverage in 2D imaging. When accelerating balanced steady-state free-precession (bSSFP) sequences with SMS-CAIPIRINHA, modulating k-space by means of slice-specific RF phase cycles leads to undesired slice-specific shifts of the bSSFP pass-band structure. Gradient-controlled local Larmor adjustment (GC-LOLA) removes this drawback. By means of slice gradient unbalancing, the Larmor frequency is made slice position dependent, which allows compensating for the pass-band shifts and stabilizes CAIPIRINHA-accelerated bSSFP imaging with respect to B0 field inhomogeneity. |
| 245 | 16:51
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Ultrafast Speech Imaging at High Spatial Resolution using Model-Consistency Condition Reconstruction with Progressive Temporal Basis Learning |
1University of Wisconsin - Madison, Madison, WI, United States |
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Dynamic MRI holds high potential for real-time imaging of upper airway, which can provide insights into questions of speech science and also have important clinical applications. However, speech imaging places increased demands on spatial and temporal resolution, necessitating image reconstruction from severely undersampled data. Previously reported methods use low-rank constraints with spiral navigators to enable temporal basis estimation, otherwise infeasible with standard learning methods. We propose an alternative solution based on a novel concept of progressive learning, which does not require separate specialized pulse sequences for navigator acquisitions, while providing high 7.4 ms temporal and 1.25x1.25x8 mm spatial resolution. |
| 246
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17:03
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3D Dynamic Hyperpolarized-13C Parallel MRI of Human Brain using SVD Low-Rank Matrix Completion |
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Department of Radiology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea |
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The goal of this feasibility study was to develop and apply new 3D dynamic hyperpolarized 13C combined parallel imaging + compressed sensing MRI methods for human brain studies. The new framework utilizing multichannel coils and low-rank matrix completion reconstruction provided greatly improved coverage as compared to prior 2D acquisitions. Whole-brain coverage was achieved, while maintaining the image quality in terms of spatial distribution, temporal dynamics and quantitative accuracy of the 13C biomarkers. Animal studies and simulations also showed that the pMRI+CS framework provided improved performance over CS alone, and was able better to recover low-SNR peaks. |
| 247
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17:15
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Reconstruction of Arrhythmic Cardiac Cycles in Patients with Atrial Fibrillation |
1New York University School of Medicine, New York, NY, United States, 2Siemens Healthineers, Erlangen, Germany |
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Arrhythmia is often a significant challenge to acquiring diagnostic quality cardiac MRI. While discarding atypical cardiac cycles can exclude short-lived arrhythmic events, such as premature ventricular contractions (PVCs), this fails for atrial fibrillation (Afib), where subjects have an irregular cardiac cycle pattern. Harnessing the potential of the XD-GRASP MRI technique to reconstruct continuously acquired data with cardiac and respiratory phase as extra dimensions, we propose to additionally classify cardiac cycles for Afib patients according to their preload state, and simultaneously reconstruct the different types of arrhythmic cycles in a five-dimensional image space. |
| 248 | 17:27
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Highly Undersampled Kooshball Reconstruction with Low-rank Modeling and Sparsity Constraints for High-resolution T1 Mapping |
1Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2Department of Radiology, University of Washington, Seattle, WA, United States |
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Highly undersampled 3D radial is very useful for 3D imaging acceleration, and compressed sensing and low-rank can be used for reconstruction of the undersampled kooshball data. In this study, we propose a novel reconstruction method for fast 3D T1 mapping of carotid artery using 3D radial sampling. The reconstruction method is based on low-rank modeling with parallel imaging and sparsity constraints, and is potential to improve the accuracy and precision of T1 estimation. The aim of this study is to evaluate the effectiveness of the proposed method using phantom and in vivo imaging experiments on volunteers and carotid atherosclerosis patients. |
| 249 | 17:39
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Assessing MR image reconstruction quality using the Fourier Radial Error Spectrum plot |
1Electrical Engineering, University of Southern California, Los Angeles, CA, United States |
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This work introduces the Fourier radial error spectrum plot (ESP) as a novel approach to quantifying the quality of reconstructed MR images. While conventional error metrics such as normalized root mean squared error (NRMSE) or structural similarity (SSIM) are widely used, they are simple scalar-measures that only provide one-dimensional insight into image quality. In contrast, ESP describes reconstruction quality with a spectrum that provides a quantitative evaluation of image quality at every spatial resolution scale. Our results show that ESP provides more comprehensive information than conventional error metrics, and can guide the design of new and improved image reconstruction approaches. |
| 250
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17:51
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Complex Image Extraction in Phased-Array Imaging |
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States |
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Phased-array coils are used in MRI to improve signal-to-noise ratio (SNR) or to accelerate data acquisition speed through parallel imaging. It is beneficial to have a phased-array imagery reconstruction method that extracts the complex magnetization information from the multichannel data. In this work, we adopt the fusion frame theory to estimate the magnitude of the underlying magnetization and further employ the matched-filter method to estimate the magnetization phase, thereby reconstructing a complex image that does not have coil sensitivity weightings. |
| 251 | 18:03
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Rapid self-tuning compressed-sensing MRI using projection onto epigraph sets |
1Electrical and Electronics Engineering Department, Bilkent University, Ankara, Turkey, 2National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey, 3Department of Electrical Engineering, Pennsylvania State University, State College, PA, United States, 4Neuroscience Program, Bilkent University, Ankara, Turkey, 5Electrical & Computer Engineering Department, University of Illinois at Chicago, Chicago, IL, United States |
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Successful compressed-sensing reconstruction often involves tuning one or more regularization weights. However, tuning the regularization weights is a subject-specific, task-dependent and non-trivial task. Recent studies have proposed to determine the weights by minimizing the statistical risk of removing significant coefficients using line searches across a range of parameters. However, the line-search procedures lead to prolonged reconstruction times. Here, we propose a new self-tuning approach generalized for multi-coil, multi-acquisition CS reconstructions that leverage projection onto epigraph sets of l1 and TV balls. The proposed method yields 7 to 9-fold gain in computational efficiency over conventional methods while enabling further improved image quality. |
| N04 | Monday 16:15 - 18:15 | Moderators: Noam Shemesh & Ileana Jelescu |
| 252
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16:15
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Breaking the power law scaling of the dMRI signal on the Connectom scanner reveals its sensitivity to axon diameters |
1Center for Biomedical Imaging, NYU School of Medicine, New York, NY, United States, 2CUBRIC, Cardiff University, Cardiff, United Kingdom |
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We demonstrate that in vivo diffusion MRI becomes sensitive to intra-axonal properties such as the inner axon diameters, when diffusion weightings in the range $$$b\sim7,000-25000\,\mathrm{s/mm^2}$$$ are achieved on the Human Connectom scanner (using gradients of 300mT/m). By analyzing the diffusion-weighted signal in the human white matter as a function of $$$b$$$, we observe significant deviations from the $$$b^{-1/2}$$$ scaling associated with the conventional “stick” model of infinitely-narrow axons. Our estimated effective MR diameters, heavily weighted by the tail of the axon diameter distribution, agree well with those calculated from histology histograms available from literature. |
| 253
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16:27
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The Dot…wherefore art thou? Search for the isotropic restricted diffusion compartment in the brain with spherical tensor encoding and strong gradients |
1CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 2Clinical sciences, Lund, Lund University, Lund, Sweden, 3Random Walk Imaging AB, Lund, Sweden |
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The accuracy of biophysical models requires that all relevant tissue compartments are modelled. The so-called “dot compartment” is a conjectured compartment that represents small cells with apparent diffusivity approaching zero. We establish an upper limit of the “dot-fraction” across the whole brain in vivo, by using ultra-high gradients and optimized gradient waveforms for spherical tensor encoding. We report a notable signal above the noise floor in the cerebellar gray matter even for an extremely high b-value of 15000 s/mm2. For cerebral tissue, the dot-fraction seems negligible, and we consider how exchange may have affected this result. |
| 254 | 16:39
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Effect of combining linear with spherical tensor encoding on estimating brain microstructural parameters |
1Radiology, New York University School of Medicine, New York, NY, United States, 2Clinical Sciences, Lund University, Lund, Sweden, 3Random Walk Imaging AB, Lund, Sweden |
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The diffusion MRI signal, as measured with conventional linear tensor encoding (LTE), has been shown to have not enough features to fully model the white matter microstructure. Here we investigate whether adding spherical encoding (STE) to LTE makes microstructural parameter estimation more robust. On signal simulations and in in vivo MRI data, we demonstrate that the intra-axonal diffusivity and axonal water fraction are estimated with higher precision, thereby enabling a 20 minute whole brain protocol to extract brain microstructural parameters without imposing constraints or priors. |
| 255 | 16:51
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Unconstrained Estimation of Microstructure by the Combination of Single- and Double-planar diffusion encoding |
1University Freiburg, Faculty of Medicine, Freiburg, Germany |
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Modeling of white matter microstructure using standard diffusion MRI protocols is a poor-conditioned problem. With standard measurements there is a global degeneracy: There are two significantly different microstructural parameter sets explaining experimental data equally well. In this work we use an additional planar double diffusion encoding to resolve the degeneracy, and extend a Bayesian estimation framework to a combination of linear and planar diffusion encoding. This enables us to produce reliable estimates without applying any constraints to the microstructural diffusion model. |
| 256
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17:03
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A Novel Method for Fast and Efficient Measurement of Diffusion Tensor Size and Shape Distributions |
1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States |
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We demonstrate through simulations and empirical data that it is possible to simultaneously estimate the variance of the voxel-wise diffusion tensor shape and size distributions using efficient isotropic and linear diffusion encodings on a whole-body clinical MRI scanner with whole-brain coverage at 3mm isotropic resolution in under 2 minutes. |
| 257 | 17:15
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The "Magic DIAMOND" method: probing brain microstructure by combining b-tensor encoding and advanced diffusion compartment imaging |
1Université de Sherbrooke, Sherbrooke, QC, Canada, 2Dept. of Radiology, Boston Children’s Hospital, Boston, MA, United States, 3MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, 4Department of Clinical Sciences, Lund, Lund University, Lund, Sweden, 5Random Walk Imaging AB, Lund, Sweden |
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Via q-trajectory encoding, b-tensors enable the disentanglement of isotropic and anisotropic diffusion components. Relevant metrics are usually extracted from data acquired with a combination of linear and spherical b-tensors with 1D parametric distributions of diffusivities. Independently, the DIAMOND model proposed an analytic result for a 6D parametric compartmental tensor distribution based on linearly acquired data. In this work, we extend DIAMOND’s analyticity to axisymmetric acquisitions. Evaluating this "Magic DIAMOND" approach on in vivo data, we show that it can tease apart isotropic diffusion and diffusivity compartments of crossing fascicles, hereby integrating specific compartments with intra-compartment diffusional variance. |
| 258 | 17:27
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On the magnetic field and echo time dependence of the pseudo-diffusion coefficient |
1Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 2Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom, 3Department Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 4Center for Medical Physics and Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 5CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom |
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It has been reported that a strong echo time dependence of the perfusion fraction f exists in liver and pancreas. The purpose of this work is to investigate whether a similar dependence exists for the pseudo-diffusion coefficient D*. Thereto, the livers of six healthy volunteers were examined at two echo times (TE = 40/80 ms) at two field strengths. In contrast to f, D* shows almost no echo time dependence in the healthy liver and the observed field strength dependence was smaller than the fit uncertainty. |
| 259 | 17:39
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Cell specific anisotropy with double diffusion encoding spectroscopy in the human brain at 7T |
1Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 2C. J. Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands |
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The measurement of intracellular metabolite mobility with diffusion weighted spectroscopy (DWS) provides a cell-specific probe for microstructure. Measurements in animals and humans with conventional one dimensional diffusion encoding and model-guided analysis suggest that the main component of the intracellular space of both neurons and astrocytes comprises mainly anisotropic fibrous geometries. In this study we performed double diffusion encoded spectroscopy (DDES) in the human brain as a direct probe of anisotropic intracellular diffusion. As expected, our results support a main fibrous component but the results also suggest a more complex geometry of astrocytes that could include isotropic compartments. |
| 260 | 17:51
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Validity Regimes of the Spherical Mean Technique |
1Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal |
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The mean spherical technique (SMT) has been proposed as an attempt to disentangle microscopic diffusion properties from the mesoscopic tissue organization. However, it remains unclear under which conditions exactly the technique could still fruitfully deliver its metrics. In this study, SMT’s microscopic fractional anisotropy estimates (μFA) are investigated using synthetic and high-quality diffusion data. We find that any compartmental heterogeneity can crucially impact the µFA extracted from SMT. In addition, the b-value ranges where SMT delivers accurate information is specific to the microstructure itself. Our work suggests that SMT-driven µFA should be examined with care. |
| 261 | 18:03
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Non-Invasive Determination of Sodium Pump Activity In Vivo with DWI |
1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 2Radiology, University of Washington, Seattle, WA, United States, 3Radiology, University of Colorado Denver, Aurora, CO, United States |
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Using a very simple model, Monte Carlo random walk simulated DWI b-space decays exhibit sensitivity to parameters measuring membrane Na+,K+-ATPase activity, cell density, and voxel average cell volume. Furthermore, the simulation matching the literature experimental in vivo human cerebral cortex b‑space decay has model parameters in near absolute agreement with the most pertinent literature values. The model parameters are: kio = 2 s-1, ρ = 80,400 cells/μL, and V = 9.2 pL. In addition, the ADC of this simulation agrees with published results. |
| S03 | Monday 16:15 - 18:15 | Moderators: Tobias Kober & Jürgen Reichenbach |
| 262
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16:15
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Simultaneous B1 and T1 Mapping Using Spiral Variable-Flip-Angle Acquisitions for Whole-Brain Coverage in Less Than One Minute |
1Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland, 2Department of Biomedical Engineering, University of Basel, Basel, Switzerland, 3High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 4Siemens Healthcare GmbH, Application Development, Erlangen, Germany, 5Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States |
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Rapid variable-flip-angle T1 mapping techniques are frequently applied in clinical settings, but their accuracy is often impaired by incomplete spoiling or flip angle miscalibrations. To eliminate these two error sources simultaneously, a combined B1 and T1 mapping method is proposed based on spiral 2D multislice spoiled gradient echo imaging with high spoiling efficiency. The transition to steady state is minimized by an optimized single preparation pulse. A single-shot spiral readout during the preparation module enables ultrafast B1 mapping and as a result reproducible bias-free T1 mapping with whole-brain coverage at clinically relevant resolution in less than one minute. |
| 263
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16:27
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Rapid simultaneous acquisition of QSM and MTV |
1Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Institute of Biomedical Engineering, Ecole Polytechnique de Montreal, Montreal, QC, Canada, 3Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States |
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Quantitative susceptibility mapping (QSM) and macromolecular tissue volume (MTV) represent quantitative methods that improve characterization of neurodegenerative diseases. MTV involves acquisition of 3D-Gradient Echo (GRE) at multiple flip angles with long TR and short TE. High-quality QSM requires 3D-GRE at multiple head orientations with long TE. We exploit (i) unused time due to long TR in MTV to collect additional late echoes that allow QSM processing, (ii) acquire each of the multiple flip angles at a different head orientation. These permit simultaneous acquisition of QSM and MTV, whereby two maps are obtained at the scan time of a single contrast. |
| 264 | 16:39
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Myelin water atlas: a template for myelin distribution in the brain |
1Physics, University of British Columbia, Vancouver, BC, Canada, 2International Collaboration on Repair Discoveries, Vancouver, BC, Canada, 3Rehabilitation Sciences, University of British Columbia, Vancouver, BC, Canada, 4Pediatrics, University of British Columbia, Vancouver, BC, Canada, 5UBC MRI Research Centre, University of British Columbia, Vancouver, ON, Canada, 6IoPPN, King's College London, London, United Kingdom, 7Radiology, University of British Columbia, Vancouver, BC, Canada, 8Medicine, University of British Columbia, Vancouver, BC, Canada, 9MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, 10UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 11ImageTech Lab, Simon Fraser University, Surrey, BC, Canada, 12University of British Columbia, Vancouver, BC, Canada, 13Physical Therapy, University of British Columbia, Vancouver, BC, Canada, 14Kinesiology, University of British Columbia, Vancouver, BC, Canada |
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In-vivo information about myelin content in the brain is desirable for studying brain diseases and injuries. Normative information is key for determining what is abnormal when assessing neurological conditions that affect myelin. We used myelin water imaging to create a template specific to myelin, the myelin water atlas, for healthy brains. The resulting atlas shows strong agreement with well-known anatomical features that have demonstrated that different brain regions have distinct amounts of myelin. Our work shows one of the potential applications of using the myelin water atlas as a reference to visualize demyelination in the brain of individual subjects. |
| 265 | 16:51
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Multi-atlas tool for automated magnetic susceptibility quantification in brain nuclei |
1Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Kennedy Krieger Institute, Johns Hopkins University, Baltimore, MD, United States, 3Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, 4Siemens Healthineers, Baltimore, MD, United States |
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Quantitative magnetic susceptibility offers a non-invasive measure of important brain tissue molecules, such as iron complexes and myelin, potentially providing significant information about normal and pathological conditions during aging. We developed an automated process to quantify tissue susceptibility in a biologically meaningful set of structures, thereby generating universal and sharable quantitative susceptibility measures. Our susceptibility-based multi-atlas outperformed the single atlas and the T1-weighted multi-atlases. Our tool and normalization algorithm offered consistent measures of magnetic susceptibility over different image protocols and platforms. Automatic and reliable quantitative susceptibility mapping measures will facilitate individual analyses and studies on aging and neurodegeneration. |
| 266 | 17:03
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High-resolution in-vivo multi-parametric MRI using MR-STAT with a highly parallelized, limited-memory reconstruction algorithm |
1Center for Image Sciences, UMC Utrecht, Utrecht University, Utrecht, Netherlands |
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MR-STAT is a framework for obtaining multiple quantitative parameter maps from a very short scan. The parameter maps are obtained by fitting a Bloch-based signal model directly to the time domain data. No Fourier transform is needed. In this work we demonstrate that MR-STAT can obtain excellent high-resolution in-vivo quantitative maps using very short Cartesian acquisitions standardly available on clinical MR systems. The solution of the large-scale reconstruction problem is made possible by a highly parallelized, limited-memory algorithm. |
| 267 | 17:15
|
Increased Measurement Efficiency for Fat Quantification Using a Mixed Polarity Bipolar Acquisition Scheme |
1St Jude Children's Research Hospital, Memphis, TN, United States |
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A new mixed polarity bipolar GRE sequence is proposed for fat quantification by mixing positive and negative readout polarity in one echo acquisition. Accurate fat fraction maps can be obtained using the proposed method with up to 50% scan time savings compared to a dual shot unipolar GRE method. |
| 268 | 17:27
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Comparison of 3D spoiled-gradient multiple echo with STEAM for proton density fat fraction and fatty acid composition estimation |
1Univ. Lyon, INSA‐Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, F69621, VILLEURBANNE, France, Lyon, France, 2Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Lausanne, Switzerland, 3Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), Centre Hospitalier Lyon Sud, Pierre-Bénite, Lyon, France, 4Hospices Civils de Lyon, Département d'imagerie digestive, CHU Edouard Herriot, Lyon, Lyon, France |
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A total of 39 volunteers underwent an imaging and spectroscopy protocol on a 3T Ingenia Philips system with an axial 3D spoiled-gradient multiple echo sequence on abdominal region and a set of three STEAM sequences acquired on subcutaneous adipose tissue, visceral adipose tissue and liver. The quantification of Proton density fat fraction (PDFF), proportion of saturated (SFA), monounsaturated (MUFA) or polyunsaturated (PUFA) fatty acids from both MRI and MRS methods were compared. Good correlation with a little bias was found for the liver PDFF. Values of PUFA, MUFA and SFA from both techniques were poorly correlated. |
| 269 | 17:39
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Quantitative Measurements of Deep Medullary Vein Caliber and Oxygenation Level Using MRI Phase and Complex Images |
1Biomedical Research Imaging Center and Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States |
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Collagenosis-induced narrowing of deep medullary vein (DMV) caliber has been implicated as one of the main causes of small vessel disease. However, a non-invasive imaging method for monitoring the DMV narrowing is still lacking. We present an MRI method for non-invasive measurement of DMV caliber and oxygenation level base on MRI phase and complex images acquired using a double echo gradient echo sequence at 7 T. The measured DMV caliber distribution agreed well with earlier report. Our approach can serve as an invaluable tool for studying the role of venous lumen narrowing in the pathogenesis of small vessel disease. |
| 270 | 17:51
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Silent T1-Mapping Using the Variable Flip Angle Method with Zero Echo Time |
1Neuroimaging, King's College London, London, United Kingdom, 2GE Healthcare, Munich, Germany, 3Medicine, University of British Columbia, Vancouver, BC, Canada, 4Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 5Radiology, University of British Columbia, Vancouver, BC, Canada |
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In this work we present a silent whole brain T1-mapping technique with zero echo time using a variable flip angle (VFA) scheme with a 3D radial sequence (RUFIS). The technique is compared to a conventional Cartesian gradient-echo based sequence (DESPOT1-HIFI) in a quantitative T1 phantom as well as in vivo in a single subject. Phantom measurements showed good agreement between techniques with average difference of 28 ms. In vivo T1 maps showed good correspondence between RUFIS and DESPOT1-HIFI. |
| 271 | 18:03
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Explicit mathematical expression for the Cramér-Rao lower bound for experimental design and parameter estimation in parallel imaging |
1National Institutes of Health, Baltimore, MD, United States |
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The Cramér-Rao lower bound (CRLB) is widely used in the design of magnetic resonance (MR) experiments for parameter estimation. Previous work has considered only Gaussian or Rician noise distributions in this calculation. However, the noise distribution for multiple-coil acquisitions, such as in parallel imaging, obeys the noncentral χ-distribution under many circumstances. Here, we present the general mathematical expression for the CRLB calculation for parameter estimation from multiple-coil acquisitions. Our results indicate that the CRLB calculation must account for the noncentral χ-distribution of noise in multi-coil acquisitions, especially in the low-to-moderate signal-to-noise ratio (SNR) regime. |
| S04 | Monday 16:15 - 18:15 | Moderators: Kerstin Timm & Jan Henrik Ardenkjær-Larsen |
| 272 | 16:15
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In vivo Imaging of Hyperpolarized Silicon-29 Nanoparticles |
1Institute for Biomedical Engineering, ETH & University of Zurich, Zurich, Switzerland, 2Labolatory of Physical Chemistry, ETH Zurich, Zurich, Switzerland |
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Hyperpolarized silicon particles exhibit very long T1 relaxation at room temperature, making them favourable as novel imaging MR probes. It has recently been shown that silicon particles in the nanometer size range can be efficiently polarized and image even after 4 hours upon transfer of the sample to the imaging system. The objective of the present work was to demonstrate the imaging capability of surface functionalized hyperpolarized nanometer size silicon particles in an experimental in-vivo setting. |
| 273 | 16:27
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An in vivo metabolic imaging study of myopathy in transgenic mice using C-13 hyperpolarized pyruvate generated by ParaHydrogen |
1Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy |
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Hyperpolarized [1-13C]pyruvate has been widely exploited for the in vivo investigation of metabolic processes under normal and diseased conditions. The possibility to obtain it using the cost effective and fast PHIP (ParaHydrogen Induced Polarization) method would allow a widespread application of this powerful diagnostic tool to pre-clinical research and would pave the way to future clinical translation. Here we show the first in vivo studies carried out on genetically modified mice using [1-13C]pyruvate obtained by means of the PHIP-SAH (PHIP-Side Arm Hydrogenation) method. The results obtained from PHIP-SAH hyperpolarized pyruvate are consistent with the pathologic state of the heart tissue. |
| 274 | 16:39
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Hyperpolarized sodium [1-13C]glycerate as a probe for assessing glycolysis in vivo |
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Electrical and Computer Engineering, University of Texas at Dallas, Richardson, TX, United States, 4Chemistry and Biochemistry, San Francisco State University, San Francisco, CA, United States, 5Stanford University, Stanford, CA, United States, 6Chemistry and Biochemistry, California State University, Fullerton, Fullerton, CA, United States |
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We describe the synthesis, development and in vivo application of sodium [1-13C]glycerate as a novel probe for evaluating glycolysis using hyperpolarized 13C MRS. [13C]glycerate displayed a high level of polarization and long spin-lattice relaxation time. In vivo spectroscopic studies with hyperpolarized [13C]glycerate in rat liver furnished metabolic products, pyruvate and lactate, originating from glycolysis. The levels of production and relative intensities of these metabolites were directly correlated with the induced glycolytic state (fasted versus fed). This work establishes hyperpolarized [13C]glycerate as a novel agent for clinically relevant 13C MRS studies of energy metabolism and further provides opportunities for evaluating intracellular redox states in biochemical investigations. |
| 275
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16:51
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Overestimation of cardiac lactate production due to liver metabolism of hyperpolarized [1-13C] pyruvate |
1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland |
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Spectroscopy is widely used in hyperpolarized metabolic experiments due to its simplicity and robustness. In this work, it is shown that with spectroscopic acquisition in rat hearts, the cardiac lactate production is overestimated due to liver metabolism of [1-13] pyruvate. It is demonstrated that this overestimation can be addressed using spatially resolved data. |
| 276 | 17:03
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Hyperpolarized 13C Metabolic Imaging of Human Hypertrophic Cardiomyopathy |
1Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3GE Healthcare, Toronto, ON, Canada, 4Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 5Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 6Cardiology, St. Michael's Hospital, Toronto, ON, Canada |
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The feasibility of using hyperpolarized 13C to interrogate in vivo human metabolism in the healthy heart has recently been demonstrated. In this abstract we demonstrate the feasibility of using hyperpolarized 13C imaging to detect metabolic alterations in human hypertrophic cardiomyopathy. Results show significantly elevated 13C-bicarbonate-to-pyruvate ratio near the apex of the heart, corresponding to the known location of disease. The 13C-bicarbonate images also show a different spatial distribution from those observed in healthy volunteers. These results show good prospects for imaging the altered cardiac energetics in the diseased heart using this technology. |
| 277
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17:15
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Imaging the healthy human brain with hyperpolarized [1-13C] pyruvate |
1Radiology, University of Cambridge, Cambridge, United Kingdom, 2Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 3Global Research, General Electric, Munich, Germany, 4Healthcare, General Electric, Cambridge, United Kingdom, 5Pharmacy, Addenbrooke's Hospital, Cambridge, United Kingdom, 6MRIS, Addenbrooke's Hospital, Cambridge, United Kingdom, 7Medicine, University of Cambridge, Cambridge, United Kingdom, 8Oncology, University of Cambridge, Cambridge, United Kingdom, 9Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, 10Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom |
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Initial results from imaging the healthy human brain with [1-13C] pyruvate are presented. Labelled lactate and bicarbonate formation are seen, as well as differences in gray and white matter perfusion. |
| 278 | 17:27
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Hyperpolarized Carbon-13 Metabolic Imaging of Pediatric Patients with Brain Tumors: Initial Experience |
1Radiology, Chonnam National University College of Medicine, Gwanju, Republic of Korea, 2Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 3Pediatric Hematology-Oncology, University of California San Francisco, San Francisco, CA, United States, 4Neurology, Neurosurgery and Pediatrics, University of California San Francisco, San Francisco, CA, United States |
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This study applied hyperpolarized 13C metabolic imaging in pediatric populations for the first time to our knowledge. Dynamic 13C data were acquired following injection of hyperpolarized [1-13C]pyruvate in the first 3 pediatric patients with brain tumors as part of an ongoing trial ( |
| 279 | 17:39
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Multimodal Characterization of In Vivo Metabolic Activities with Hyperpolarized 13C MRI, 18F-FDG PET, and EPR Imaging in Pancreatic Ductal Adenocarcinoma Tumors |
1National Cancer Institute, National Institutes of Health, Bethesda, MD, United States |
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Profiling the metabolic and physiologic phenotypes of tumors has become important in treatment planning and response monitoring. Here, multimodal imaging methods, including hyperpolarized 13C MRI, 18F-FDG PET, and EPRI imaging, were used to profile the metabolic and physiologic features of human pancreatic ductal adenocarcinoma (PDAC) tumors, Hs766t, MiaPaCa-2, and SU.86.86. PDACs have some of the worst prognoses of all cancers. Experimental results have demonstrated, for the first time, the feasibility and advantages of multimodal metabolic and physiologic assessment of xenograft tumors. This multimodal imaging approach will complement tumor characterization, lead to better prognostics, and earlier response monitoring in cancer treatment. |
| 280
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17:51
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The Rate of Hyperpolarized [1-13C] Pyruvate to [1-13C] Lactate Conversion Distinguishes High-Grade Prostate Cancer from Low-Grade Prostate Cancer and Normal Peripheral Zone Tissue in Patients |
1Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA, United States, 2The Graduate Group in Bioengineering, Universities of California at Berkeley and San Francisco, Berkeley and San Francisco, CA, United States, 3Urology, University of California at San Francisco, San Francisco, CA, United States, 4Pathology, University of California at San Francisco, San Francisco, CA, United States |
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The accurate discrimination of aggressive from indolent prostate cancer at diagnosis remains a pressing clinical need. High spatial and temporal resolution 3D dynamic hyperpolarized 13C MRSI has previously demonstrated the ability to correlate hyperpolarized (HP) [1-13C]pyruvate to [1-13C]lactate conversion, kPL, with cancer grade in murine models. This initial analysis of patients studies enrolled in a phase II pre-prostatectomy clinical trial demonstrated for the first time that maxmium kPL (kPLmax) is significantly elevated in high-grade prostate cancer versus both normal (p=0.0003) and low-grade disease (p=0.034). |
| 281 | 18:03
|
Detection of D-amino acid oxidase using hyperpolarized molecular probes |
1Laboratory for Functional and Metabolic Imaging (LIFMET), EPFL, Lausanne, Switzerland, 2Center for Biomedical Imaging (CIBM), Lausanne, Switzerland |
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D-amino acid oxidase (DAO) is an enzyme that catalyzes the degradation of D-amino acids in the body. Here, we explored the possibility of detecting D-amino acid oxidase activity by monitoring its metabolism in the rat kidney after a bolus injection of hyperpolarized D-[1-13C]alanine. Our data show that D-alanine is readily converted to lactate only when the DAO enzyme is not inhibited, indicating that the observed metabolism is that of DAO. |
| S05 | Monday 16:15 - 18:15 | Moderators: Pierre Croisille & Andrew Scott |
| 282 | 16:15
|
Magnetic susceptibility of hemorrhagic myocardial infarction: correlation with tissue iron and comparison with relaxation time MRI |
1Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 2Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 3Biophysics, University of Pennsylvania, Philadelphia, PA, United States, 4Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, United States, 5Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 6Surgery, Columbia University, New York City, NY, United States |
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Hemorrhagic myocardial infarction (MI) is a frequent complication of primary percutaneous coronary intervention and independently associated with impaired LV remodeling, function, and arrhythmias. We demonstrate that cardiac quantitative susceptibility mapping (QSM) shows increased susceptibility in infarcts compared to remote myocardium and correlates with iron content and infarct pathophysiology. QSM is a more specific marker of hemorrhagic MI than relaxation time MRI, susceptibility-weighted imaging, and late gadolinium enhanced (LGE) MRI. |
| 283 | 16:27
|
Myocardial T2 mapping using a Black-blood hEart-rate Adaptive T2-prepared bSSFP (BEATS) sequence |
1Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States, 2Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China, 3Department of Computer Science, Technical University of Munich, Munich, Germany, 4Biomedical Engineering Department, Cairo University, Giza, Egypt, 5Department of Radiology, Peking University First Hospital, Beijing, China, 6Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States |
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Quantification of T2 in areas bordering myocardium and blood pool is challenging due to partial volume errors. Blood signal suppression would effectively reduce partial volume effects and improve image contrast at the blood-myocardium boundaries. This study proposed a Black-blood hEart-rate Adaptive T2-prepared bSSFP (BEATS) sequence for myocardial T2 mapping to improve blood-myocardial border definition. Both phantom and in vivo studies proved the advantages of BEATS sequence compared to T2prep-bSSFP T2 mapping. The proposed BEATS sequence efficiently suppresses the blood signal, resulting in better definition of blood/myocardium border by reducing the impact of partial volume effect in T2 measurements, which improves the assessment of edema post myocardial infarction. |
| 284 | 16:39
|
Assessment of Myocardial Fibre Architecture in Cardiac Amyloidosis Patients using In-Vivo Cardiac Diffusion Tensor Imaging |
1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2Department of Cardiology, University Hospital Zurich, Zurich, Switzerland, 3Dept. Cardiology, Pneumology and Angiology, Heinrich Heine University, Düsseldorf, Germany |
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In-vivo cardiac diffusion tensor imaging (cDTI) allows imaging of alterations in the cardiac fibre architecture in diseased hearts. In this work, changes in the myocardial microstructure in patients with cardiac amyloidosis were assessed using cDTI and T1 mapping. Mean diffusivity and T1native are significantly increased in the patients and the helical fibre configuration is comparable to healthy controls. There is a trend towards higher/lower MD/FA with increased T1native, respectively. In agreement with T1 mapping, diffusion results support the presence of myocardial degeneration and emphasize the potential of cDTI as contrast agent free tool for characterizing cardiac involvement in amyloidosis patients. |
| 285 | 16:51
|
Cardiac Magnetic Resonance Elastography for the Diagnosis of Patients with Heart Failure with Preserved Ejection Fraction |
1Radiology, Mayo Clinic, Rochester, MN, United States |
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Heart failure with preserved ejection fraction (HFpEF) accounts for half of incident heart failure cases per year. Currently, the diagnostic reference standard is invasive. The objective of this study is to evaluate if cardiac MR elastography (MRE) can measure increased myocardial stiffness in patients with HFpEF. Fifty-eight volunteers and 10 patients were enrolled. The mean left-ventricle myocardial stiffness of HFpEF patients (10.5±1.7 kPa) was significantly higher (p=0.002) than control subjects (8.0±1.2 kPa).This study motivates further investigation into the use of cardiac MRE as a quantitative noninvasive imaging technique to assist in the diagnosis and therapy monitoring of patients with HFpEF. |
| 286
|
17:03
|
Cardiac Phase-resolved Late-Gadolinium Enhancement Imaging |
1Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 3Computer Assisted Clincial Medicine, Heidelberg University, Mannheim, Germany, 4University of Minnesota, Minneapolis, MN, United States, 5Working Group on Cardiovascular Magnetic Resonance Imaging, Max-Delbrück-Centrum and Charité -Medical University Berlin, Berlin, Germany, 6Department of Cardiology and Nephrology, HELIOS Klinikum Berlin-Buch, Berlin, Germany |
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Late Gadolinium Enhancement (LGE) is commonly acquired during a single end-diastolic phase with inversion-recovery contrast that nulls healthy myocardial tissue. In this work, we propose a method for acquisition of cardiac phase-resolved LGE images based on an ECG triggered Look-Locker experiment with continuous FLASH imaging. Semi-quantitative evaluation of this pulsed-inversion recovery allows synthetization of LGE image contrast for all cardiac phases. Accurate functional depiction with temporal resolution up to 60 ms is obtained in healthy subjects at 3T. Images of 20 patients on a clinical 1.5T scanner show promising depiction of focal scar at a temporal resolution of 80ms. |
| 287
|
17:15
|
High resolution in-vivo diffusion tensor cardiovascular magnetic resonance: a comparison of single-shot EPI and interleaved spiral trajectories with motion induced phase correction |
1Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, United Kingdom, 2National Heart and Lung Institute, Imperial College, London, United Kingdom, 3National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States |
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The spatial resolution of DT-CMR STEAM acquisitions was increased by implementing an interleaved variable density spiral readout. Bulk motion during STEAM diffusion encoding is unavoidably encoded in the image phase which can result in signal loss for multi-shot acquisition when the multiple interleaves are combined. A phase correction was implemented using the fully sampled centres of k-space to calculate the differences in phase between interleaves. In 7 volunteers we show improved data quality at 2.0x2.0mm2 using interleaved spirals compared to single-shot EPI and we obtain similar DT-CMR parameters. |
| 288 | 17:27
|
Microvascular obstruction impacts recovery of T1 and T2 relaxation and strain parameters following acute myocardial infarction |
1Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, 2Schulich Heart Research Program, Sunnybrook Research Institute, Toronto, ON, Canada, 3Division of Cardiology, St. Michael's Hospital, Toronto, ON, Canada, 4Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada |
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Microvascular obstruction (MVO) is a frequent complication in acute myocardial infarction (AMI). A comprehensive regional and serial characterization of tissue response in the presence and absence of MVO will help assess the high-risk patients. In this study, we utilized T1 and T2 relaxation as well as tissue strain properties to evaluate tissue response in STEMI patient’s post-AMI. We observed that measures of infarct edema, hemorrhage and strain in patients with MVO fail to recover to remote levels and have significantly lower recovery rates compared to patients without MVO. Remote T2 alterations may further be an early indicator of adverse remodeling. Our study shows that MVO impacts disease progression by hindering the regional myocardial systolic function and edema recovery post-AMI. |
| 289 | 17:39
|
The effects of cardiac allograft vasculopathy on intimal coronary artery wall thickness, myocardial fibrosis, and myocardial extracellular volume |
1Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, 2Center for BioMedical Imaging (CIBM), Lausanne, Switzerland, 3Cardiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, 4Pathology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, 5School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom |
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Cardiac allograft vasculopathy (CAV) occurs with a high prevalence after heart transplantation (HTx) and is a major cause of mid-term to late heart transplant failure. In this study we investigated whether the presence of CAV as diagnosed by x-ray coronary angiography or intima thickness as assessed by optical coherence tomography (OCT) is linked with the myocardial T1 relaxation time, extracellular volume, or interstitial fibrosis as assessed by endomyocardial biopsies (EMB). |
| 290 | 17:51
|
The Difference between Extracellular Space Expansion and Diffuse Myocardia Fibrosis in Defferent Severity Distolic Dysfunction (DD) Type 2 Diabetes Mellitus (T2DM) Rhesus Monkeys using Excellelar Volume mapping and Non-contrast T1ρ mapping |
1West China Hospital, Sichuan University, Chengdu, China, 2Sichuan Primed Bio-Tech Group Co., Ltd, Chengdu, China, 3Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States |
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In this study, diffuse myocardial fibrosis was quantifitied in type 2 diabetes mellitus (T2DM) rhesus monkeys with different severity diastolic dysfunction (DD) using ECV derived from T1 mapping and mFI derived from non-contrast T1ρ mapping. Different behaviors of ECV and mFI to differentiate HC from T2DM with mild DD was observed. This reflects the difference between extracellular space expansion and collagen content during the process of myocardial fibrosis. This difference is benifite for us to better understand the pathophysiology of DD. |
| 291 | 18:03
|
Intravoxel incoherent motion MR imaging: Evaluation of myocardial microcirculation in diabetes patients |
1Radiology, Dalian medical university, Dalian, China, 2Dalian medical university, Dalian, China |
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Because of 80% type 2 diabetic patients died of cardiovascular complications, diabetic microangiopathy in the diabetic cardiomyopathy couldn’t be ignored. At present, we lack simple and accurate methods for assessment of myocardial microcirculation. Intravoxel incoherent motion (IVIM) technology is a new noninvasive method that can be used for quantitatively assessing myocardial microcirculation status. |
| S06 | Monday 16:15 - 18:15 | Moderators: Alon Leeor & Filiz Yetisir |
| 292
|
16:15
|
Reduction of Peripheral Nerve Stimulation (PNS) using Pre-Excitation Targeting the Potassium System (PRE-TAPS) |
1Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 2Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 3Harvard Medical School, Boston, MA, United States, 4Department of Anesthesiology Mannheim, Heidelberg University, Mannheim, Germany, 5Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States |
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PNS has become the main limitation of fast MRI using current gradient hardware. We recently presented a novel pipeline to simulate magnetically induced PNS thresholds in arbitrary coil geometries. Now, we use this framework and detailed modeling of ion dynamics and Action Potential (AP) generation to test a new strategy for PNS reduction. The method (which we call “PRE-TAPS”) pre-saturates the nerve membrane by playing gradient pulses prior to the main imaging gradient. Our model suggests that this simple pulse-sequence modification could effectively increase PNS thresholds by up to 30%. |
| 293
|
16:27
|
On-line Subject-Specific Local SAR Assessment by Deep Learning |
1Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, 2MR Code BV, Zaltbommel, Netherlands, 3Biomedical Image Analysis, Eindhoven University of Technology, Eindhoven, Netherlands |
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One of the most critical aspects that limits the application of ultra-high field MRI is the local Specific Absorption Rate (SAR) evaluation. The key aspect is that local SAR information could only be obtained by off-line simulation using generic body models, which hardly match with the patient's body and positioning. In this work we present a first deep learning approach for local SAR assessment. Results, show that the relation between local SAR on the one hand and MR Dixon images and B1-field maps on the other hand, can be accurately and instantaneously mapped by a Convolutional Neural Network (CNN). |
| 294 | 16:39
|
NEUROMAN: Reference Computational Human Phantoms for Evaluation of Safety Thresholds for Peripheral Nerve Stimulation |
1IT'IS Foundation, Zürich, Switzerland, 2Department of Anatomy, Ajou University, Suwon, Republic of Korea, 3Department of Anatomy, Dongguk University, Gyeongju, Republic of Korea, 4ETH, Zürich, Switzerland |
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The trend towards stronger magnetic fields and/or faster gradient switching in magnetic resonance imaging poses safety risks for patients, e.g., due to tissue heating and unwanted neurostimulation. The IEEE-ICES TC95 SC6 was formed to re-evaluate nerve excitation safety thresholds in response to temporal and spatial characteristics of electric fields induced by externally applied fields or implants. To this end, we are developing reference human anatomical models with unprecedented details in the peripheral nervous system, connectivity to organs and muscles, and functionalized with compartmental nerve models to investigate interactions with neuronal electrophysiology. We employ these phantoms to investigate current safety guidelines. |
| 295 | 16:51
|
Workflow proposal for defining SAR safety margins in parallel transmission |
1NeuroSpin, CEA, Saclay, France, 2Irfu, CEA, Saclay, France |
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SAR calculations in parallel transmission (pTx) typically rely on electromagnetic simulations performed on generic models. Uncertainties however often exist due to tolerances in the lumped element values, cable losses, phase offsets and different coupling between transmit elements. Additional uncertainties in SAR evaluation include intersubject variability and exam supervision. In this work, we review a workflow that has been implemented in our laboratory with home-made and commercial pTx coils at 7T. Based on this strategy, nearly 100 healthy volunteers have been scanned with no reported incidents, while still allowing to exploit pTx to mitigate efficiently the RF inhomogeneity problem. |
| 296
|
17:03
|
SAR estimation error due to body model mismatch for fetal imaging at 3 Tesla |
1Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, 2A.A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 3Harvard Medical School, Boston, MA, United States, 4Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Boston, MA, United States, 5Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 6Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States |
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RF safety concerns have been raised for both the mother and the fetus for 3 T fetal MRI. Parallel transmission can address these concerns by reducing the maternal and fetal SAR however it also relies on one or more body models to predict that individual’s local SAR. In this work, we assess the range of error incurred when various pregnant or non-pregnant models are used to predict SAR in pregnant patients. We model the degree of over or underestimation of SAR in 56 combinations of model/patient and find a maximum SAR under/over-estimation of 59%/142%. |
| 297 | 17:15
|
Optimizing the Topography of Transmit Coils for SAR Management |
1Electrical and Electronics Engineering Department, Bilkent University, Ankara, Turkey, 2National Magnetic Resonance Research Center (UMRAM), Ankara, Turkey, 3Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 4Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, United States |
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Specific absorption rate (SAR) is a significant issue for ultra-high field (UHF, B0≥7T) imaging. In this study, we investigate a strategy based on optimizing the topography of transmit elements in 3D (i.e., adding bumps to a resonant planar structure) in order to reduce the local SAR while keeping B1+ efficiency constant inside a region of interest. For proof of concept, we modified three different resonant structures and compared their performance to previous designs with EM simulations. In addition, we built one of the proposed design and experimentally tested it using a whole-body 10.5T scanner. |
| 298 | 17:27
|
Magnetic resonance imaging in patients with cardiac implanted electrical devices: single centre two year experience including thoracic imaging and non-MRI conditional devices. |
1Clinical Physics, Barts Health NHS Trust, London, United Kingdom, 2Medical Physics and Engineering, Kings College London, London, United Kingdom, 3Department of Cardiovascular Imaging, Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom, 4Institutes for Cardiovascular Science, University College London, London, United Kingdom, 5National Institutes of Health, Bethesda, MD, United States, 6William Harvey Research Institute, Queen Mary University of London, London, United Kingdom |
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Over a million patients worldwide have cardiac implantable electronic devices (CIEDs), with a 50-75% lifetime MRI requirement. Although conventionally contraindicated, MRI-conditional CIEDs and evidence supporting safer scanning of non-MRI conditional CIEDs are changing practice. We report single center experience of CIED MRI scanning over 24 months. 179 MRI scans were acquired, 31% non-MRI conditional devices, 79% thoracic scans. Clinical impact was high (including cancer diagnosis and treatment planning, suspected cord compression and stroke). All patients were safely scanned with no clinically-significant events or device parameter changes resulting from MRI. These data support increased provision of MRI to CIED patients. |
| 299
|
17:39
|
Exploring the impact of nulling currents on a cardiac guidewire in reducing worst case SAR at 1.5T |
1Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom |
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MRI with non-MR compatible objects, namely wires, poses several challenges as risks of high Local SAR and reduced image quality due to B1 enhancement. In this work we looked at previously proved current nulling techniques and at their relationship with the reduction of worst case SAR scenarios. Results showed that current nulling leads to large reductions in worst case SAR, but that performance varies with coil design and sensor location. The analysis could be used to aid design of experimental setup for maximum safety. |
| 300 | 17:51
|
Reduction of the absorbed power around electrode tips in deep brain stimulation patients using pTx: Impact of number and arrangement of channels |
1Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Psychiatry, Massachusetts General Hospital, Charlestown, MA, United States |
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We assess the potential of pTx for reduction of the absorbed power around electrode tips (APAET) in DBS patients using a realistic DBS patient model and electromagnetic field co-simulation. We simulate 5 coils, including a birdcage coil driven in quadrature and as a 2-channel pTx coil as well as four pTx coils with up to 16 channels arranged in up to two rows. We compare magnitude least square pulses with explicit constraints on the APAET and global SAR. We show that pTx, especially using head-only arrays, has the potential to alleviate the safety problem of DBS patients at 3 Tesla. |
| 301 | 18:03
|
Comparison between experimental and simulated electric fields near a hip implant in a parallel transmit hip coil |
1School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia, 2School of Public Health and Preventive Medicine, Population Health Research on Electromagnetic Energy, Monash University, Australia, 3Siemens Healthcare Pty Ltd, Brisbane, Australia, 4Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia |
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The high conductivity of metal implants causes them to focus electric fields in tissue, which may increase the local temperature. In the case of parallel transmit (pTx) MRI, careful simulations of the patient and coil are required to predict heating, but validation of the simulations is challenging near metal implants. In this work, direct measurement of E-field near a hip prosthesis is performed inside a pTx hip coil, and results are compared with simulated data with and without considering decoupling. Neglecting decoupling leads to differences of up to 80% with measured data, showing the importance of realistic simulations. |
| W03/04 | Monday 16:15 - 18:15 | Moderators: Weiying Dai & David Thomas |
| 302 | 16:15
|
Advanced Automatic Planning for Super-Selective Arterial Spin Labeling Flow Territory Mapping |
1Philips Research, Hamburg, Germany, 2Philips Healthcare, Best, Netherlands |
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This study presents an advanced fully automated approach based on vessel detection and analysis. It is completely integrated in the scanner console and allows labeling of the major brain feeding vessels in an efficient and robust way. Average processing time to find optimal labeling positions for all major brain feeding arteries is <15 seconds. |
| 303
|
16:27
|
Non-contrast assessment of blood-brain-barrier permeability with water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST) MRI |
1Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Department of Neurology, Johns Hopkins University, Baltimore, MD, United States, 3Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 4Department of Radiology, New York University Langone Medical Center, New York, NY, United States |
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A new method for non-contrast assessment of blood-brain-barrier (BBB) permeability to water has been proposed: water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST) MRI, which allows selective imaging of venous ASL signal. Studies were performed to show proof-of-principle and Look-Locker readout were applied to expedite data acquisition. The results were consistent with previous literature. Mild hypercapnia was also shown to enhance the sensitivity of the technique significantly. |
| 304
|
16:39
|
Investigation into water transport mechanisms in the brain using a combination of T2 measurements and crusher gradients with ASL |
1C.J. Gorter Center for High Field MRI, Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Leiden Institute of Brain and Cognition, Leiden, Netherlands |
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TRUST and crusher gradients were combined with time-encoded pCASL to examine the transport of water from the vasculature to the tissue in the brain. At early time points, where the intravascular portion of the ASL signal is high, the crusher gradients resulted in a large reduction in the average signal. By comparing the intravascular fraction obtained from crushed signal to T2 measurements, it was observed that the change in T2 is greater in later time points than the change in intravascular fraction. This suggests that T2 methods are more sensitive to alterations in the blood-brain barrier than crusher gradient techniques. |
| 305 | 16:51
|
Arterial Spin Labeled Input Function (ASLIF): signal acquisition during pseudo-continuous arterial spin labeling |
1Fraunhofer MEVIS, Bremen, Germany, 2University Bremen, Bremen, Germany, 3mediri GmbH, Heidelberg, Germany |
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In ASL pseudo-continuous labeling (pCASL) is often used as a labelling scheme due to its increased SNR compared to pulsed variants. After labeling and a subsequent post-labeling delay, the amount of labeled blood in the organ of interest is acquired. In this abstract, we describe a new approach, which allows to measure the blood signal while it is labeled. Results are presented for a four-phase Hadamard-encoded pCASL sequence. This will ultimately allow for a realtime monitoring of the arterial input function in pCASL. |
| 306
|
17:03
|
Time-encoded golden angle radial ASL |
1C.J. Gorter Center for high field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Philips, Best, Netherlands |
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The golden angle readout provides a flexible approach to acquire multiple reconstructions, each with a different trade-off between spatial and temporal resolution from the same dataset. In combination with a Hadamard labeling scheme, the golden angle readout can be optimized for reconstructions at multiple spatial resolutions, allowing for multi-slice acquisition. By changing to single-slice acquisition, high temporal resolution angiography and high quality perfusion images can be reconstructed from a single dataset. |
| 307 | 17:15
|
Cerebral Blood Volume Mapping using Fourier-Transform based Velocity-Selective Saturation Pulse Trains |
1Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China, 4Ewha Womans University, Seoul, Republic of Korea, 5Case Western Reserve University, Cleveland, OH, United States |
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A new non-contrast cerebral blood volume (CBV) quantification technique is proposed using Fourier-transform based velocity-selective saturation (FT-VSS) pulse trains. Its utility is assessed for healthy subjects at 3T and compared to a method using conventional flow-dephasing VS pulse trains. FT-VSS showed greater immunity to gradient imperfections and up to 40% higher SNR. The better performance of FT-VSS pulse trains in CBV measurements can be explained by the effective background suppression related to its velocity-selective profile: static tissue signal in the saturation band and flowing spins in the passband, which is opposite from the velocity response of the conventional method. |
| 308 | 17:27
|
Robust estimation of quantitative perfusion from multi-phase pseudo-continuous arterial spin labelling |
1Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, 2Cancer Research UK & Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom, 3Wellcome Centre for Integrative Neuroimaging, FMRIB, University Oxford, Oxford, United Kingdom |
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Multi-phase pcASL has been proposed as a means to achieve accurate perfusion quantification that is robust to imperfect shim in the labelling plane. There exists a previously unrecognised bias in the estimation process that is a function of noise on the data. In this work this boas is addressed, exploiting information common to voxels containing tissue fed by the same artery, identified using clustering methods. |
| 309
|
17:39
|
Optimized Scan Design for ASL Fingerprinting and Multiparametric Estimation using Neural Network Regression |
1Dept of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, United States, 2FMRI Laboratory, University of Michigan, Ann Arbor, MI, United States |
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We investigate an optimization method for ASL fingerprinting acquisition schemes as well as a neural network framework for estimating hemodynamic parameters from the data. |
| 310 | 17:51
|
Improving Perfusion Image Quality and Quantification Accuracy Using Multi-contrast MRI and Deep Convolutional Neural Networks |
1Radiology, Stanford University, Stanford, CA, United States, 2Electrical Engineering, Stanford University, Stanford, CA, United States, 3Global Applied Science Lab, GE Healthcare, Menlo Park, CA, United States |
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We propose a novel method that uses deep convolutional neural networks (dCNNs) to combine multiple contrasts from MRI, including single- and multi-delay pseudo-continuous arterial spin labeling (PCASL) and structural scans, to synthesize perfusion maps that approach the accuracy of the PET perfusion measurements. The dCNN was trained and tested on both healthy and patient datasets, and demonstrated significant improvement on both image quality (higher structural similarity and lower normalized root mean square error) and quantification accuracy (regional CBF comparable with PET) than either ASL method alone. This method may potentially be generalized to other qualitative/quantitative applications. |
| 311
|
18:03
|
Acceleration of arterial spin labeling data acquisition using spatio-temporal total generalized variation (TGV) reconstruction |
1Institute of Medical Engineering, Graz University of Technology, Graz, Austria, 2Institute of Mathematics and Scientific Computing, University of Graz, Graz, Austria, 3Department of Neurology, Medical University of Graz, Graz, Austria, 4BioTechMed-Graz, Graz, Austria |
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3D imaging sequences such as GRASE or RARE-SoSP are the preferable choice for acquiring ASL images. However, a tradeoff between the number of segments and blurring in the images due to the T2 decay has to be chosen. In this study we propose a reconstruction algorithm based on total generalized variation for reducing the number of segments and therefore the acquisition time of one image. We incorporate the averaging procedure in the reconstruction process instead of reconstructing each image individually. This allows exploiting temporal redundancy and spatial similarity for improving the reconstruction quality of ASL images. |
| W07 | Monday 17:15 - 18:15 | (no CME credit) |
| W08 | Monday 17:15 - 18:15 | (no CME credit) |
| W03/04 | Monday 18:30 - 19:30 | (no CME credit) |
| W05/06 | Monday 18:30 - 19:30 | (no CME credit) |
Organizers: Stephan Maier, Jennifer McNab, Noam Shemesh
| N03 | Tuesday 7:00 - 7:50 | Moderators: Qiyuan Tian & Chris Clark |
| 7:00 | Next-Generation Diffusion Anisotropy Mapping Techniques for Neurosurgery |
| Timothy Shepherd |
| 7:25 | Using Tractography to Guide Tumor Resections |
| Natalie Voets |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Jongho Lee, Utaroh Motosugi, Yi-Fen Yen
| N04 | Tuesday 7:00 - 7:50 | Moderators: Koji Sakai & Yi-Fen Yen |
| 7:00 | Basic Physics of Multiband Imaging |
| Berkin Bilgic |
| 7:25 | Clinical Applications of Multiband Imaging |
| Seung Hong Choi |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Kathryn Fowler, Catherine Hines, Kartik Jhaveri, Lorenzo Mannelli, Valeria Panebianco, Scott Reeder, Reiko Woodhams
| S01 | Tuesday 7:00 - 7:50 | Moderators: Victoria Chernyak & Jeffrey Brown |
| 7:00 | Pre-Treatment |
| Andrea Rockall |
| 7:25 | Monitoring response to therapy |
| Nandita deSouza |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Sebastian Kozerke, Reza Nezafat
| S02 | Tuesday 7:00 - 7:50 | Moderators: Jessica Bastiaansen & Angus Lau |
| 7:00 | Imaging Cardiac Metabolism |
| Marie Schroeder |
| 7:25 | Imaging of Cardiac Microstructure |
| Christian Stoeck |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Guanshu Liu, Natalie Serkova, Damian Tyler
| S03 | Tuesday 7:00 - 7:50 | Moderators: Fabao Gao & Damian Tyler |
| 7:00 | Recent Technical Developments of Molecular Imaging in Cardiovascular Diseases |
| Michal Neeman |
| 7:25 | Clinical Translation & Applications of Molecular MRI in Cardiovascular Diseases |
| René Botnar |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Eric Chang, Garry Gold, Emily McWalter, Edwin Oei, Philip Robinson
| S04 | Tuesday 7:00 - 7:50 | Moderators: Emily McWalter & Sander Brinkhof |
| 7:00 | Physiologic Articular Cartilage Imaging |
| Stefan Zbyn |
| 7:25 | Clinical Articular Cartilage Imaging with Emerging MR Methods |
| Pia Jungmann |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Andre Obenaus, Pia Maly Sundgren
| S05 | Tuesday 7:00 - 7:50 | Moderators: Minming Zhang & Christopher Smyser |
| 7:00 | Nicotine - Effects in Brain Functional Connectivity |
| Victor Vergara |
| 7:25 | Imaging of the Developing Brain |
| Serena Counsell |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Gregor Adriany, Matthias Günther, Michael Hansen, Christoph Juchem, Greig Scott
| S06 | Tuesday 7:00 - 7:50 | Moderators: Mary McDougall & Greig Scott |
| 7:00 | Techniques for Generating a Field |
| Patrick Goodwill |
| 7:25 | Magnet-Building Tutorial |
| Jason Stockmann |
| 7:50 | Adjournment & Meet the Teachers |
| Exhibition Hall 1554-1573 | Tuesday 8:15 - 10:15 | (no CME credit) |
| Exhibition Hall | Tuesday 8:15 - 9:15 | (no CME credit) |
| Exhibition Hall | Tuesday 8:15 - 9:15 | (no CME credit) |
Organizers: Michael Steckner
| S06 | Tuesday 8:15 - 10:15 | (no CME credit) |
8:15
|
Introduction & Overview | |
1TMRU |
8:20
|
PNS Investigations, Unresolved Issues & Novel Solutions | |
1University of Western Ontario |
8:43
|
Exploring the PNS Characteristics of the Connectome Gradients | |
1Siemens Healthineers |
9:06
|
State-of-Art Neuron Models | |
9:29
|
A New Neuron Model for MRI Exposures | |
1Heidelberg University, Mannheim, Germany |
9:52
|
Cardiac Implant Vendor Understanding of Electric Field Threshold Values Necessary to Stimulate the Heart | |
1Medtronic, Inc. |
Organizers: Linda Knutsson, Esben Petersen, Sophie Schmid
| W03/04 | Tuesday 8:15 - 10:15 | Moderators: Eric Achten & Linda Knutsson | (no CME credit) |
8:15
|
What is QIBA? | |
1Oregon Health Sciences University, United States |
8:30
|
What is EIBALL? | |
1Institute of Cancer Research, Surrey, United Kingdom |
8:45
|
QIBA Profile on DSC | |
1MGH Athinoula A Martinos Center, Charlestown, MA, United States |
9:00
|
QIBA Profile on DCE | |
9:15
|
QIBA Profile on ASL | |
1Gold Standard Phantoms Limited |
9:30
|
QA in Clinical Trials Using Phantoms | |
1Radiology, UT Southwestern Medical Center, Dallas, TX, United States |
9:45
|
Panel Discussion |
Organizers: Christopher Smyser, Pia Maly Sundgren
| S01 | Tuesday 8:15 - 10:15 | Moderators: Christopher Smyser |
8:15
|
Glucose & the Developing Brain: What Do We Know? | |
1Washington University |
8:45
|
Effects of Nutrition on Brain Development | |
1University Medical Center Utrecht, Netherlands |
9:15
|
Using MRI/S to Study Metabolic Signatures of Early Brain Development & Disease | |
1Kanagawa Children's Medical Center, Kanagawa, Japan, 2National Institute of Radiological Sciences, Chiba, Japan |
||
In the developing brain, metabolites concentrations such as NAA, choline and myo-inositol show dynamic change. We can use 1H-MRS to measure such metabolite concentrations. It is important to know such signature for the precise evaluation of neonatal brain pathology, particularly in hypoxic-ischemic encephalopathy. 1H-MRS is also a powerful tool for the diagnosis and disease monitoring forpediatric neuro-metabolic diseases. |
9:45
|
Advanced Neuroimaging Techniques to Study Brain Metabolism in Pediatric Populations | |
1USC/Childrens Hospital Los Angeles, United States, 2Rudi Schulte Research Institute, Santa Barbara, CA, United States |
||
In this presentation, various methods that have been used or could potentially be used to study metabolism in the pediatric brain are presented. Beyond widely available proton (1H) MR spectroscopy, this includes phosphorus (31P) MRS, carbon 13 (13C) MRS methods as well as MR imaging approaches that measure the cerebral metabolic rate of oxygen. |
10:15
|
Adjournment & Meet the Teachers |
| Power Pitch Theater A - Exhibition Hall | Tuesday 8:15 - 9:15 | Moderators: Douglas Noll & Peder Larson | (no CME credit) |
| 312 | 8:15
|
Imaging of the Thoracic Spinal Cord using Radially Sampled Averaged Magnetization Inversion Recovery Acquisitions (rAMIRA) |
1Division of Radiological Physics, Dept. of Radiology, University Hospital Basel, Basel, Switzerland, 2Dept. of Biomedical Engineering, University of Basel, Basel, Switzerland, 3Dept. of Radiology, University Hospital Basel, Basel, Switzerland |
| 313 | 8:15
|
FLAWS imaging improves depiction of the thalamic subregions for DBS planning in epileptic patients |
1Radiology, University Hospital of Rennes, Rennes, France, 2VISAGES ERL U-1228, Univ Rennes, Inria, CNRS, Inserm, IRISA UMR 6074, Rennes, France, 3LTSI, Université de Rennes 1, Rennes, France, 4U1099, INSERM, Rennes, France, 5Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 6Radiology, University Hospital Lausanne (CHUV), Lausanne, Switzerland, 7Signal Processing Laboratory, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 8Neurology, University Hospital of Rennes, Rennes, France, 9Neurosurgery, University Hospital of Grenoble, Grenoble, France, 10Neurosurgery, University Hospital of Rennes, Rennes, France |
| 314 | 8:15
|
Silent T2* Encoding using ZTE Combined with Gradient-Echo Burst (BURZTE) |
1GE Healthcare, Munich, Germany, 2IMAGO7 Foundation, Pisa, Italy, 3GE Healthcare, Menlo Park, CA, United States |
| 315 | 8:15
|
Using 3D high-resolution MR Fingerprinting (MRF) to assist detection and characterization of epileptic lesions |
1Radiology, Case Western Reserve University, Cleveland, OH, United States, 2Epilepsy Center, Cleveland Clinic, Cleveland, OH, United States, 3Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 4Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, 5Neuroradiology, Cleveland Clinic, Cleveland, OH, United States |
| 316 | 8:15
|
An Optimized Single-shot Sequence for Fast T2w Imaging of the Brain |
1Electrical and Computer Engineering, University of Arizona, Tucson, AZ, United States, 2Medical Imaging, University of Arizona, Tucson, AZ, United States, 3Biomedical Engineering, University of Arizona, Tucson, AZ, United States |
| 317
|
8:15
|
The UK7T Network – optimized design of a multi-site, multi-vendor travelling heads study. |
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 3Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom, 4Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, 5Institute of Neuroscience & Psychology, University of Glasgow, Glasgow, United Kingdom |
| 318 | 8:15
|
Evaluation of a wave-MPRAGE sequence for brain morphometery |
1Center for Brain Science, Harvard University, Cambridge, MA, United States, 2AA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 3Department of Psychology, Harvard University, Cambridge, MA, United States, 4Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, United States |
| 319 | 8:15
|
Methods to accelerate STAGE: Toward 8 min for Twelve 3D images on 1.5T |
1Neusoft Medical System, Shanghai, China, 2Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China, 3The MRI Institute for Biomedical Research, Detroit, MI, United States, 4Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang, China, 5Department of Radiology, School of Medicine, Wayne State University, Detroit, MI, United States |
| 320 | 8:15
|
Accelerated quantitative susceptibility and R2* mapping with flexible k-t-segmented 3D-EPI |
1MR Physics, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 2Medical Physics Group, Institute of Diagnostic and Interventional Radiology, University Hospital Jena, Jena, Germany, 3Department of Neurology, Essen University Hospital, Essen, Germany, 4Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany, 5Department of Physics and Astronomy, University of Bonn, Bonn, Germany |
| 321 | 8:15
|
Myelin Lipid 1H Density Measurements by IR-UTE are Consistent Before and After D2O Exchange |
1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Department of Chemistry, Temple University, Philadelphia, PA, United States, 4SAIF Core Facility, Children's Hospital of Philadelphia, Philadelphia, PA, United States |
| 322 | 8:15
|
Formalin Tissue Fixation Biases Myelin Density Measurement by Quantitative Magnetization Transfer and Myelin Water Imaging |
1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 5Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States |
| 323 | 8:15
|
High Resolution Diffusion Tensor Imaging of the Hippocampus in Temporal Lobe Epilepsy |
1Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Neurology, University of Alberta, Edmonton, AB, Canada |
| 324
|
8:15
|
Repeatability of measuring pulsatile brain tissue motion and volumetric strain with retrospectively-gated DENSE at 7T |
1Radiology, University Medical Center Utrecht, Utrecht, Netherlands |
| 325 | 8:15
|
Isotropic 3D quantification of R1 and R2 relaxation and proton density in 6 minutes scan time |
1SyntheticMR, Linköping, Sweden, 2Center for Medical Imaging Science and Visualization (CMIV), Linköping, Sweden, 3Radiation Physics, Linköping, Sweden, 4Center for Medical Imaging Science and Visualization (CMIV), Linkoping, Sweden |
| 326 | 8:15
|
Zero Time of Echo imaging with an Adiabatic Fat Suppression Pulse at 7T |
1GE Healthcare, Pisa, Italy, 2Imago7, Pisa, Italy, 3IRCCS Stella Maris, Pisa, Italy, 4GE Healthcare, Munich, Germany, 5GE Healthcare, Waukesha, WI, United States, 6University of Pisa, Pisa, Italy, 7King's College London, London, United Kingdom |
| Power Pitch Theater B - Exhibition Hall | Tuesday 8:15 - 9:15 | Moderators: Eric Sigmund & Karyn Chappell | (no CME credit) |
| 327 | 8:15
|
Intramuscular variability and sex difference in diffusion properties and 3D architecture of human lower leg muscles assessed with ultra-high-field diffusion tensor imaging and tractography |
1Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, 2Siemens Healthcare, Erlangen, Germany, 3APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 4Institut NeuroMyoGène, Université Claude Bernard Lyon 1, INSERM, CNRS, Villeurbanne, France |
| 328 | 8:15
|
Time-dependent diffusion and the random permeable barrier model predict muscles fiber dimensions in Duchenne muscular dystrophy mice |
1Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Human Genetics, Leiden University Medical Center, Leiden, Netherlands, 3Radiology, New York University School of Medicine, New York, NY, United States |
| 329 | 8:15
|
Relationship of paraspinal muscle DTI metrics to isometric strength measurements |
1Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universität München, München, Germany, 2Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technische Universität München, München, Germany, 3Department of Sport and Health Sciences, Technische Universität München, München, Germany |
| 330 | 8:15
|
Imaging human motor unit activity using MRI. |
1Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 2Newcastle University, Newcastle upon Tyne, United Kingdom, 3Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom, 4Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom |
| 331 | 8:15
|
Clinical Feasibility of Isotropic MAVRIC SL Imaging of Total Joint Arthroplasties |
1Hospital for Special Surgery, New York, NY, United States, 2General Electric Healthcare, Waukesha, WI, United States |
| 332 | 8:15
|
Solid-State MRI as a noninvasive alternative to computed tomography for craniofacial imaging |
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Plastic Surgery, University of Pennsylvania, Philadelphia, PA, United States |
| 333 | 8:15
|
Subregional bone marrow adipose tissue composition in the proximal femur: Comparison of 3T Chemical Shift Encoded-MRI and Magnetic Resonance Spectroscopy |
1Radiology, NYU Langone Health, New York, NY, United States, 2Université de Lyon; CREATIS CNRS UMR 5220, Inserm U1206, INSA-Lyon, UCBL Lyon 1, Villeurbanne, France, 3Osteoporosis Center, Hospital for Joint Diseases, NYU Langone Health, New York, NY, United States, 4Department of Rheumatology, NYU Langone Health, New York, NY, United States |
| 334 | 8:15
|
Temporal Changes of a Canine Model of Patellar Tendinopathy Using UTE MRI T2* Assessment: A Pilot Study |
1Department of Radiology and Imaging - MRI, Hospital for Special Surgery, New York, NY, United States, 2Cornell University, Ithaca, NY, United States, 3VetPath Services, Stone Ridge, NY, United States |
| 335 | 8:15
|
Knee Cartilage UTE T2* Quantification with Water-Fat Decomposition |
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Global MR Applications and Workflow, General Electric, San Diego, CA, United States, 3Joint Graduate Program in Bioengineering, University of California, San Francisco/Berkeley, San Francsico, CA, United States |
| 336 | 8:15
|
Strategies for Obtaining Relaxation Rates due to Chemical Exchange from Parameter Free Atomistic Simulations |
1University of Oulu, Oulu, Finland, 2Oulu University Hospital, Oulu, Finland |
| 337 | 8:15
|
Automatic Segmentation of Hip Cartilage with Deep Convolutional Neural Nets for the evaluation of Acetabulum and Femoral T1ρ and T2 relaxation times. |
1Center for Digital Health Innovation, University of California, San Francisco, San Francisco, CA, United States, 2Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States |
| 338 | 8:15
|
Assessment of the clinical feasibility of routine T2 mapping of the intervertebral disc using highly undersampled k-space data |
1High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Department of Orthopaedics, Medical University of Vienna, Vienna, Austria, 3Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 4Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, 5LTS5, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 6High Field MR Centre of Excellence, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria |
| 339 | 8:15
|
Voxel-wise ratios of amide proton transfer (APT) signals and standardized uptake values (SUVs) of fluorodeoxyglucose (FDG) in the differentiation of myxoid-rich soft-tissue tumors with FDG-PET/MR imaging |
1Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 3Healthcare, Philips Electronics Japan, Tokyo, Japan, 4Philips Research, Hamburg, Germany, 5Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan |
| 340 | 8:15
|
Assessment of early treatment response by multiparametric whole-body MRI as a 1-step approach to prediction of overall response rate in patients with multiple myeloma |
1Department of Diagnostic Radiology, Hiroshima University Hospital, Hiroshima, Japan |
| 341
|
8:15
|
Simultaneous Bilateral Knee MR Imaging |
1Radiology, Stanford University, Stanford, CA, United States, 2Radiology, Erasmus MC, Rotterdam, Netherlands |
Organizers: Kathryn Fowler, Kartik Jhaveri, Lorenzo Mannelli, Valeria Panebianco, Scott Reeder, Mustafa Shadi Bashir, Claude Sirlin, Reiko Woodhams
| S02 | Tuesday 8:15 - 10:15 | Moderators: Daniel Margolis & Alberto Vargas |
8:15
|
Prostate Cancer: Defining Clinically Significant Disease | |
1National Cancer Institute, United States |
||
The goal of performing MRI in prostate cancer is to help distinguish indolent, low risk prostate cancers from those harboring clinically significant features. This presentation reviews the criteria for clinically significant tumors and underscores the benefits that accrue when using MRI as a gateway for the diagnosis of prostate cancer. |
| 342 | 8:45
|
T2-weighted MRI-derived textural features can help the assessment of peripheral zone prostate cancer aggressiveness: results from multi-center data. |
1Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway, 2Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands, 3St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway |
||
The assessment of prostate cancer aggressiveness is currently based on Gleason grading of histological samples obtained by TRUS-guided biopsies, which can lead to substantial underestimations due to sampling errors. We previously showed that textural features derived from T2-weighted MRI could potentially serve as a non-invasive biomarker for prostate cancer aggressiveness. The aim of this work was to validate these preliminary results in a multi-center study. We found that the combination of intensity and textural features could distinguish between low/intermediate and high-grade with an accuracy of 71%, which was significantly higher than intensity (60%) or textural features (68%) alone. |
| 343 | 8:57
|
Radiomics measured with mpMRI predicts histopathological and genomics markers of prostate cancer aggressiveness. |
1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, United States |
||
The goal of this study was to assess the association of multiparametric MRI (mpMRI) radiomic features with histopathological and genomic markers of prostate cancer (PCa) aggressiveness. mpMRI histogram and texture features showed multiple significant correlations with Gleason score, modified Gleason score Grade Group and genomics Decipher risk score. General linear models showed high accuracy for prediction of the histopathological and genomics features (accuracy range 0.77-0.94). The results indicate that MRI radiomics analysis is promising for noninvasive assessment of PCa aggressiveness on the histopathological and genomics levels. |
9:09
|
Current State-Of-The-Art Imaging Protocol: Where Are The Gaps? | |
1Joint Dept of Medical Imaging - MSH, University of Toronto, Canada |
||
In Pi-Rads v2 there are technical recommendations for performance of multiparametric MRI (mpMRI) of the prostate. When using this protocol there are several issues that lead to suboptimal or non-diagnostic images that remain unaddressed. Some of these can be mitigated through altering patient preparation or a changing of pulse sequence parameters. Further optimization and development of robust pulse sequences and imaging systems to improve prostate MRI image quality is an unmet need that can benefit from further research. A second critical area in need of further development is related to value which goes hand in hand with cost reduction. This is also tied to the growing and controversial concerns related to repeated Gd administration for DCE MRI and the unknown long-term effects of Gd deposition in the brain in an otherwise healthy patient population with long life expectancy. The necessity of DCE MRI and the potential of proton spectroscopy to replace DCE MRI are other potential areas of innovation. |
| 344 | 9:39
|
Reduced distortion in prostate DWI by using split echo type TSE-DWI (SPLICE) with MultiVane acquisition |
1Philips Japan, Shinagawa, Tokyo, Japan, 2Department of Radiology, Gifu University Hospital, Gifu, Japan, 3Philips Healthcare, Shinagawa, Tokyo, Japan |
||
To reduce image distortion in prostate DWI, split-echo type TSE-DWI (SPLICE) was combined with MultiVane (current Philips implementation of PROPELLER) acquisition, named MV-SPLICE. To avoid non-CPMG artifacts in SPLICE, the spin echoes and stimulated echoes were separated by the unbalanced readout gradient and acquired in separate MultiVane k-space for separate reconstruction. ADCs and SNRs in transition zone and peripheral zone, and distortion for DWI and T2W images in the anterior-posterior direction of prostate diameter for MV-SPLICE were compared to conventional EPI and MultiVane TSE-DWI (MV-ALSOP). We demonstrated that MV-SPLICE is insensitive to distortion and can provide comparable ADC measurement. |
| 345 | 9:51
|
Accelerated 3D 1 mm isotropic T2w-Imaging of the Prostate in less than 3 min |
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Siemens Healthcare Limited, Frimley, United Kingdom, 3Cancer Imaging, King's College London, London, United Kingdom |
||
Three dimensional (3D), isotropic T2-weighted imaging of the prostate requires a long acquisition time. Here we propose a 3D T2-prepared multi-shot bSSFP acquisition with a variable density undersampled trajectory and TV-SENSE reconstruction. Results from a healthy volunteer study demonstrate that 3D 1 mm isotropic resolution T2-weighted images of the prostate can be acquired in 2 min 45 s, with image quality that is comparable to the clinical standard turbo spin echo sequences but only takes 1/3 of the acquisition time. |
| 346 | 10:03
|
Targeted Biopsy Validation of Peripheral Zone Prostate Cancer Characterization with MR Fingerprinting and Diffusion Mapping |
1Radiology, Case Western Reserve University, Cleveland, OH, United States, 2School of Medicine, Case Western Reserve University, Cleveland, OH, United States, 3Radiology, Johns Hopkins University, Baltimore, MD, United States, 4Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, 5Biostatistics, Case Western Reserve University, Cleveland, OH, United States, 6Urology, Cleveland Clinic, Cleveland, OH, United States, 7Urology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States |
||
Targeted biopsy validation is presented for characterization of peripheral zone (PZ) prostate cancer grades and differentiation of prostate cancer from prostatitis, using a quantitative MR protocol comprising of MRF-relaxometry and standard EPI based ADC mapping. Mean T1, T2 and ADC in prostate cancer were significantly lower than in NPZ. Mean T2 and ADC in low-grade cancer were significantly higher than intermediate and high-grade cancer with similar AUCs (0.80) for both for differentiating grades. Mean T2 and ADC in prostate cancer were significantly lower than prostatitis. T2 was a significant predictor for prostate cancer over prostatitis while ADC was not significant. |
10:15
|
Adjournment & Meet the Teachers |
Organizers: Vikas Gulani, James Pipe
| S03 | Tuesday 8:15 - 10:15 | Moderators: Vikas Gulani & James Pipe |
8:15
|
Measuring the Value of MRI: Comparative Effectiveness & Outcomes Research | |
1NYU Medical Center, United States |
||
With growing emphasis on value in health care, there is a need to assess the effects of MRI use on patient health outcomes. The value, or the health outcomes relative to the cost, can be studied using established comparative effectiveness research and outcomes assessment methods. The synthesis of clinical context with test use also allows for analyses of personalized decision making based on test information. The major methods described will include decision analysis, cost effectiveness, and study of intermediate outcomes. These methods can allow for quantification of population level health benefits, comparison with other tests or interventions, and identification of research priorities based on predicted impact. |
8:37
|
The Meaning of MR Value to Underserved Populations: Thoughts & Initial Technical Experience | |
1Dayanada Sagar College of Engineering, India |
8:49
|
Questions |
| 347
|
8:55
|
Diagnostic Comparison of Two Rapid Knee MRI Protocols for Comprehensive Whole-Joint Assessment: A Multi-Reader Feasibility Study |
1Radiology, Stanford University, Palo Alto, CA, United States, 2Harvard Medical School, Stanford, MA, United States, 3Radiology & Nuclear Medicine, Erasmus Medical Center, Rotterdam, Netherlands |
||
There were approximately 1.25 million clinical knee magnetic resonance imaging (MRI) scans performed in the US annually. Most knee MRI protocols require approximately 30 minutes of scan time. However, there is interest in expedited imaging protocols, especially under the ISMRM Value Initiative. Through a study involving 35 patients and 5 readers, we have demonstrated the feasibility of (1) a single 5-minute DESS sequence and (2) a 5-minute DESS sequence paired with a 2-minute coronal PDFS sequence, as two potential methods for accurate, rapid, and comprehensive diagnostic whole-joint knee MRI. |
| 348 | 9:00
|
How Fast is “Fast MRI” for Breast Cancer Screening? |
1Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States |
||
We compare the scan and total study times from a newly implemented abbreviated MR protocol (AP) for breast cancer screening consisting of localizer, T2-STIR, and single pair of pre- and post-contrast 3D T1 sequences to similar times from our full MRI screening protocol. A retrospective analysis was performed using scan time data obtained from image dicom files as well as data from the Radiology Information System (RIS) for technologist activity times to determine the variance between the two protocols. The results of this study will help guide operational value improvements and estimates for appropriate pricing for the newly implemented AP for breast cancer screening. |
| 349 | 9:05
|
Benefits and Challenges of Spiral MRI in Routine Clinical Brain Imaging: Early Results |
1Philips Healthcare, Gainesville, FL, United States, 2Barrow Neurological Institute, Phoenix, AZ, United States, 3Phoenix Children’s Hospital, Phoenix, AZ, United States, 4Philips Innovation Campus, Bangalore, India, 5Philips Healthcare, Best, Netherlands, 6Philips Healthcare, Tokyo, Japan, 7Philips Healthcare, Gurgaon, India, 8Nationwide Children’s Hospital, Columbus, OH, United States, 9University of Texas Southwestern Medical Center, Dallas, TX, United States, 10Kyushu University Hospital, Fukuoka, Japan, 11University of Michigan, Ann Arbor, MI, United States, 12Lahey Hospital & Medical Center, Burlington, MA, United States, 13Fortis Memorial Research Institute, Gurgaon, India, 14University of Washington, Seattle, WA, United States, 15Dent Neurologic Institute, Amherst, NY, United States |
||
Spiral MRI possesses several advantages vs. Cartesian MRI, due to differences in their k-space trajectories and underlying MR physics, which can be leveraged for added value in routine clinical imaging. A Spiral Neuroimaging Cooperative, consisting of nine clinical sites, was formed for the multi-center evaluation of spiral MRI as an alternative to Cartesian MRI in routine clinical imaging. Post-contrast brain spiral 2DT1SE were compared with Cartesian 2DT1SE or TSE. Spirals demonstrated faster scanning with consistent flow artifact reduction vs. both Cartesian options, and superior overall image quality (T1 contrast, lesion visualization) vs. TSE. |
| 350 | 9:10
|
30 brain MRI exams in 1 hour using a multi-contrast EPI sequence |
1Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden, 2Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, 3MR Applied Science Laboratory Europe, GE Healthcare, Stockholm, Sweden |
||
An in-house developed multi-contrast EPI sequence producing six MR contrasts (T1-FLAIR, T2-w, DWI, ADC, T2*-w, and T2-FLAIR) was used as a fast brain MRI protocol. Seven healthy volunteers were scanned repeatedly to investigate how many brain MRI exams that can be performed over the course of one hour. With a net scan time of one minute and an additional minute for table movements and switch of subjects, it was possible to perform 30 brain MRI examinations in 1 h. |
| 351 | 9:15
|
Rapid Synthetic MRI of the whole brain using simultaneous multi-slice technique |
1Global MR Applications & Workflow, GE Healthcare, Menlo Park, CA, United States, 2Global MR Applications & Workflow, GE Healthcare, Waukesha, WI, United States, 3SyntheticMR, Linköping, Sweden |
||
Synthetic MRI enables reconstruction of multiple MRI contrasts from a single scan based on voxel-wise computation of relaxation parameters. This can improvement scan productivity and workflow considerably. The utility of synthetic MRI has recently been demonstrated in clinical settings. However in its current implementation whole brain coverage can be achieved within 5 minutes only if a thick slice prescription (~ 4mm) is used, but this might provide insufficient through-plane resolution for certain clinical protocols and can also lead to partial voluming effects. This work explores the simultaneous multislice approach for more efficient through plane coverage with synthetic MRI. |
| 352 | 9:20
|
Decision Curve Analysis for Prostate Biopsy using MRI with or without Dynamic Contrast Enhancement |
1Radiology, NYU School of Medicine, New York, NY, United States |
||
Prostate MRI with dynamic contrast enhancement (DCE) is controversial with growing interest in noncontrast (NC) MRI. Decision curve analyses performed on data from two contemporary studies identified ranges of high grade cancer probability thresholds at which DCE had the highest net benefit. DCE MRI has the most benefit in moderate or moderate-high risk threshold ranges, thought to vary based on the study differences in disease prevalence, reference standard, and the presence or absence of additional DCE reconstruction images. The risk ranges in which NC versus DCE MRI optimize net benefit may help inform the best clinical use of prostate MRI. |
| 353 | 9:25
|
Impact of Routine Magnetic Resonance Imaging on Diagnosis and Treatment of Women with Benign Gynecologic Conditions Seen in a Multidisciplinary Fibroid Center |
1Radiology, Stanford University, Stanford, CA, United States, 2Medicine, Stanford University, Stanford, CA, United States, 3Obstetrics & Gynecology, Stanford University, Stanford, CA, United States |
||
Pelvic ultrasounds often represent the first and only line of imaging for uterine fibroid evaluation. Our study aims to determine the added value of routine pelvic magnetic resonance imaging (MRI) on diagnosis and treatment of women presenting with symptomatic uterine fibroids. A retrospective review was performed on 569 consecutive women referred to our multidisciplinary fibroid center over a three-year period. Compared to ultrasound alone, MRI affected diagnosis in over a third of patients, which also altered treatment options. These findings justify the use of routine pelvic MRI in women with symptomatic fibroids, particularly those presenting with dysmenorrhea. |
| 354 | 9:30
|
Staging hemodynamic failure: BOLD fMRI cerebrovascular reactivity beats [15O]-H2O-PET. |
1Neuroradiology, University Hospital Zurich, Zurich, Switzerland, 2Neurosurgery, University Hospital Zurich, Zurich, Switzerland, 3Pharmacology & Toxicology, University Hospital Zurich, Zurich, Switzerland, 4Neurology, University Hospital Zurich, Zurich, Switzerland, 5Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland |
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The actual gold standard stroke risk assessment is cerebral blood flow (CBF) measured with [15O]-H2O-PET, which is available only in few specialized centers and requires ~1mSv radioactive dose. Otherwise, quantitative CVR measurements derived (with our temporal decomposition iterative algorithm) from Blood-Oxygen-Level-Dependent (BOLD) fMRI with CO2 challenge might apply as a surrogate imaging-marker for hemodynamic failure, as the <7 minutes acquisition can easily be clinically implemented, and has – as proved in this study – twice higher specificity*sensitivity for staging hemodynamic failure in chronic cerebrovascular steno-occlusive diseases than PET. Therefore, BOLD CVR shall be widely implemented for assessing stroke risk. |
| 355 | 9:35
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A solar powered MR spectrometer system |
1MRI, ISD Ltd, Bradley, United Kingdom, 2Academic Radiology, University of Sheffield, Sheffield, United Kingdom |
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Most MRI systems have very high electrical power consumption and require extensive cryogenic support systems. A spectrometer design has been developed for a low cost, low weight and low power specialised MR system capable of ‘unplugged’ operation for worldwide use in remote locations. |
| 356 | 9:40
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REconstruction of MR images acquired in highly inhOmogeneous fields using DEep Learning (REMODEL) |
1Medical Imaging Research Centre, Dayananda Sagar College of Engineering, Bangalore, India, 2Dept. of Radiology, Columbia University Medical Center, New York, NY, United States |
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The aim of this study was to develop and demonstrate a supervised learning algorithm to reconstruct MR images acquired in highly in-homogeneous magnetic fields. Brain images were used to train a deep neural network. This was performed for image sizes of 32 x 32 and 64 x 64. Results obtained demonstrate REMODEL’s ability to reconstruct the images obtained in in-homogeneous magnetic fields of up to ±50 kHz with high fidelity. The root-mean-square-error for these reconstructions compared to the uncorrupted ground truth was lesser than 0.15 and significantly lesser than the corrupted images. |
| 357 | 9:45
|
Creating Standardized MR Images with Deep Learning to Improve Cross-Vendor Comparability |
1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States |
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A very common task for radiologists is to compare sequential imaging studies that were acquired on different MR hardware systems, which can be difficult and inaccurate because of different designs across scanners and vendors. Cross-vendor standardization and transformation is valuable for more quantitative analysis in clinical exams and trials. With in-vivo multi-vendor datasets, we show that it is possible to achieve accurate cross-vendor transformation using the state-of-art Deep Learning Style-transfer algorithm. The method preserves anatomical information while transferring the vendor specific contrast "style". The usage of unsupervised training enable the method to further train and apply on all existing large scale MRI datasets. This technique can lead to a universal MRI style which benefits patients by improving inter-subject reproducibility, enabling quantifiable comparison and pushing MRI to be more quantitative and standardized. |
9:50
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Panel Discussion |
10:15
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Adjournment & Meet the Teachers |
| N01 | Tuesday 8:15 - 10:15 | Moderators: Bettina Baessler & Krishna Nayak |
| 358 | 8:15
|
Improved 2D cardiac Cine MRI with retrospective gating using Golden-angle Radial acquisition and Angle-Based echo-Sharing (GRABS) |
1UIH America, Inc., Houston, TX, United States, 2United Imaging Healthcare, Shanghai, China |
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Cardiac Cine MRI with retrospective gating using Golden-angle Radial acquisition and Angle-Based echo-Sharing is a promising technique permitting retrospective gating, arbitrary temporal resolution, and arrhythmia data rejection. It is an easy-to-implement and effective technique that features improved image quality by reducing streaking artifacts. |
| 359
|
8:27
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Feasibility of Ultra-high Simultaneous Multi-slice and In-plane Accelerations for Cardiac MRI Using Outer Volume Suppression and Leakage-Blocking Reconstruction |
1Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 3Computer Assisted Clincial Medicine, University of Minnesota, Mannheim, Germany |
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Simultaneous multi-slice (SMS) imaging has gained increasing interest for enabling high scan-time acceleration at the cost of minimal loss in SNR. However, its applications in cardiac MRI have been limited, as the feasible acceleration is restricted by unfavorable coil geometry. In this study, we investigate the use of outer-volume suppression (OVS) in combination with CAIPIRINHA to promote dissimilarities among the multi-bands. We propose a time and SAR efficient multi-band scheme for OVS and apply these techniques with a leakage blocking reconstruction to increase the feasible acceleration in cardiac cine and perfusion imaging. Combining these techniques, we achieve clinical image quality with 5 fold SMS acceleration in Cine and 16-fold spatial-only acceleration in perfusion MRI. |
| 360 | 8:39
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Feasibility of absolute myocardial blood flow quantification using Simultaneous Multi Slice (SMS) SSFP first-pass myocardial perfusion imaging and iterative reconstruction at 1.5 Tesla. |
1Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom, 3Siemens Healthcare, Erlangen, Germany, 4The Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia |
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Quantification of myocardial blood flow (MBF) enhances diagnosis and provides prognostic information. Simultaneous Multi Slice (SMS) imaging allows greater spatial coverage of the heart with minimal signal-to-noise penalty and is thus desirable for perfusion imaging. 5 patients underwent two rest perfusion scans using a dual-bolus technique with SMS protocol (6 slices) and iterative reconstruction and standard 3 slice bSSFP sequence. Absolute MBF was quantified with a fermi-constrained deconvolution algorithm. Global and territorial MBF was comparable between the different methods. Future evaluation in patients with stress testing and greater heart coverage may provide clinical utility in patients with coronary artery disease. |
| 361 | 8:51
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Improving compressed sensing reconstructions for myocardial perfusion imaging with residual artifact learning |
1Radiology & Imaging Sciences, University of Utah, Salt lake city, UT, United States, 2US MR R&D Collaborations, Siemens Healthineers, Salt Lake City, UT, United States, 3Cardiology, University of Utah, Salt Lake City, UT, United States |
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Compressed sensing/constrained reconstruction methods have been successfully applied to myocardial perfusion imaging for improving in-plane resolution and improving slice coverage without losing temporal resolution. |
| 362
|
9:03
|
Beat-by-Beat Dynamic Assessment of Myocardial Oxygenation with Highly Time-Resolved, Free-breathing, Ungated Cardiac T2 BOLD MRI Using a Low-Rank Tensor Formulation |
1Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, United States, 2Lawson Research Institute, London, Canada, 3Siemens Healthineers, Los Angeles, CA, United States, 4Cedars Sinai Medical Center, Los Angeles, CA, United States |
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Coronary vasodilation and the ensuing myocardial hyperemia following the administration of a provocative stressor is a dynamic process. However, established perfusion methods are confounded by contrast accumulation and lack the temporal resolution to accurately evaluate the process. BOLD CMR is an emerging method for monitoring myocardial perfusion without contrast agents, but the current methods are slow. We developed a non-ECG-gated, free breathing, beat-to-beat, cardiac/respiratory phase-resolved, T2-based BOLD CMR sequence at 3T using a low rank tensor framework to enable highly time-resolved assessment of coronary reactivity. We tested the proposed technique in an animal model with and without coronary disease. |
| 363
|
9:15
|
Non-invasive pressure-volume loops from cardiovascular magnetic resonance and brachial pressure |
1Department of Clinical Physiology, Skåne University Hospital, Lund University, Lund, Sweden, 2Department of Biomedical Engineering, Faculty of Engineering, Lund University, Lund, Sweden |
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Cardiac pressure-volume loop analysis provides important information on cardiac function, but is currently not widely utilized clinically since invasive measurements are required. This study aimed to develop and validate a non-invasive method of estimating pressure-volume loops, via a model-based framework using cardiovascular magnetic resonance. The method yields individualized pressure-volume loops computed using time-varying elastance, with left ventricular volume and brachial pressure as input. Experimental validation showed strong agreement to in-vivo measurements, and application to healthy controls and heart failure patients yielded expected results. Hence, the model is a promising method for obtaining pressure-volume loops from magnetic resonance imaging. |
| 364 | 9:27
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Subtle changes in hyperelastic properties of myocardium with cardiotoxicity remodeling from CMR |
1Mechanical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 2Biomedical Engineering, University of Auckland, Auckland, New Zealand, 3Anatomy with Radiology, University of Auckland, Auckland, New Zealand, 4Kinesiology, University of Montreal, Montreal, QC, Canada |
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The aim of this study was to assess subtle changes in 3D geometrical and mechanical properties of left ventricle in childhood acute lymphoblastic leukemia survivors. Global 3D volume or ejection fraction were not sensitive enough while time dependent 3D geometrical parameters over the cardiac cycle showed that early diastole is more affected than systole or late diastole. Smaller hyper-elastic properties were found in the high risk group than in the standard risk, high risk with cardioprotective agent or healthy volunteers group. High temporal resolution and local parameters would improve the detection of these subtle changes. |
| 365
|
9:39
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Self-gated free-breathing cine DENSE imaging by adaptively reducing residual T1-echo energy |
1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 2Radiology, University of Virginia, Charlottesville, VA, United States |
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Cine DENSE is a well-established myocardial strain imaging technique that typically requires breath-holding. In this study, we developed a self-gated free-breathing adaptive acquisition algorithm that reduces free-breathing artifacts by minimizing the residual energy of the phase-cycled T1-relaxation signal. The algorithm adaptively repeats the acquisition of the k-space data with the highest residual T1-echo energy. Evaluation in 7 healthy subjects demonstrated that the method provides high quality free-breathing self-gated cine DENSE images in a clinically-reasonable scan time. |
| 366
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9:51
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Assessment of Regional Myocardial Velocities by Tissue Phase Mapping and Feature Tracking in Healthy Children and Pediatric Patients with Hypertrophic Cardiomyopathy: A Comparison Study |
1Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 2Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 3Department of Pediatrics, Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States, 4Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 5Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States, 6Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Chicago, IL, United States |
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In this study, we compare tissue phase mapping (TPM) and feature tracking (FT) of standard cine SSFP images for the assessment of regional myocardial velocities in 15 pediatric patients with hypertrophic cardiomyopathy (HCM) and 20 age-matched healthy controls. Data analysis included the calculation of segmental (AHA 16-segment model) left ventricular radial and long-axis peak velocities in systole and diastole. Both techniques detected significantly decreased diastolic velocities in HCM patients compared to controls, suggesting reduced myocardial relaxation despite normal ejection fraction. Lower temporal resolution of FT derived velocities resulted in systematically lower peak velocities compared to directly measured TPM velocities. |
| 367 | 10:03
|
Cardiac Single Breath-hold Balanced SSFP Cine ‘Watermark’ provides Cardiac Function via Magnitude and 2D Myocardial Strain via Phase |
1MRI Research Center, Auburn University, Auburn, AL, United States, 2Siemens Healthineers, Malvern, PA, United States |
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Cardiac MRI myocardial tagging enables quantification of myocardial strain. However, tagging remains limited to a research context due to the time-intensive analysis and need to run multiple sequences. CMR sequences must be fast and efficient. We previously developed a FLASH-based cine sequence called Cine ‘Watermark’ (CWM) that acquires normal cine magnitude images plus ‘hidden’ (via phase) cardiac strain data for calculating myocardial strain. Here we present a Balanced SSFP (bSSFP) version of CWM that presents improved SNR and scan efficiency. The bSSFP CWM is demonstrated in human subjects at 3T and its performance is compared to conventional Grid-Tagging MRI. |
| N02 | Tuesday 8:15 - 10:15 | Moderators: Luis Hernandez-Garcia & Seong-Gi Kim |
| 368
|
8:15
|
Unraveling Cardiac and Respiratory Contributions to Brain Tissue Motion using Single Shot 2D DENSE at 7T MRI. |
1Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Neurology, University Medical Center Utrecht, Utrecht, Netherlands |
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The cardiac cycle and respiration both influence CSF dynamics and therefore the displacement of brain tissue. In this work we unravel their contribution to brain tissue displacement using a single shot 2D cine displacement-encoded imaging method employing stimulated echoes (DENSE) for brain motion measurements. Displacement-encoded data sets in the Feet-to-Head direction of seven volunteers were fitted to a linear model. Consistent trends in displacements were observed. The developed DENSE sequence results showed similar sized contributions to brain tissue displacement. Relating these displacements to contributions to the clearance system remains future work. |
| 369
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8:27
|
Macromolecular proton fraction closely correlates with myelin loss in the rat ischemic stroke model |
1Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russian Federation, 2Massachusetts General Hospital, Charlestown, MA, United States, 3Institute of Cytology and Genetics SB RAS, Novosibirsk, Russian Federation, 4Siberian State Medical University, Tomsk, Russian Federation, 5Department of Radiology, University of Washington, Seattle, WA, United States |
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Non-invasive quantitative assessment of myelin damage in ischemic stroke is currently unavailable. The goal of this study was to evaluate a recently proposed myelin imaging technique, macromolecular proton fraction (MPF) mapping in the rat stroke model and compare it with histological myelin quantitation. MPF decrease in the brain infarct closely correlated (R = 0.81, p<0.001) with luxol fast blue staining on the 1st, 3rd, and 10th day after stroke. Further improvement in accuracy of myelin quantitation (R = 0.98) was achieved with the use of bivariate linear regression model including T2 to correct errors related to edema. |
| 370 | 8:39
|
The effect of breath-hold on cardiovascular pulse in the brain - a multimodal MREG study. |
1OFNI/Radiology, Oulu University Hospital, Oulu, Finland |
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MREG enables critical sampling of human brain physiology. This study reveals novel pulsation changes during repeated breatholds of 32 seconds. Cardiorespiratory control centers in the brain stem show increased pulsation amplitude during the end of the breathold. Also the overall cardiac pulse propagation in the brain alters markedly by breathold, especially when repeated. The findigs show that the MREG data enables spatially accurate estimation of the status of the cardiovascular pulsation which is the primary driver of glymphatic brain clearance. |
| 371
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8:51
|
ASL imaging and 31P/1H-MRS during prolonged breath-hold among experienced freedivers: Insights into cerebrovascular and metabolic responses |
1Department of Radiology, University Hospital Bonn, Bonn, Germany, 2Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 3Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada, 4Radiology Department, Amsterdam Medical Center, Amsterdam, Netherlands, 5Department of Anesthesiology, University Hospital Bonn, Bonn, Germany, 6Philips Healthcare, Bonn, Germany, 7Philips Healthcare, Best, Netherlands, 8Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, 9Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany |
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This pCASL and 31P/1H-MRS study explored the cerebrovascular reactivity (CVR) and its efficacy on brain metabolic stability during a five-minute breath-hold in fifteen experienced freedivers. Cerebral blood flow (CBF) increase occurred later than the decrease of the recently discovered arterial transit time correlate, spatial CoV. The latter may thus be an early CVR biomarker. CBF varied between vessel territories, gray and white matter and usually lowered with more experience. MRS showed near stable physiological cerebral pCr, ATP and pH concentrations despite peripheral lactate acidosis. In conclusion, this trial revealed that CVR sufficiently compensates the metabolic challenge of a five minute breath-hold. In conclusion, this trial revealed that cerebral perfusion increase sufficiently compensates the metabolic challenge of a five-minute breath-hold. |
| 372 | 9:03
|
Sensitivity and specificity of cerebrovascular reactivity in predicting surgical decisions in Moyamoya patients |
1Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2University of Texas Southwestern Medical Center, Dallas, TX, United States |
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Moyamoya disease (MMD) is characterized by chronic occlusion of the distal intracranial internal carotid arteries and can be treated by revascularization surgery. At present, surgical decisions are primarily based on symptomatology and imaging studies such as DSA and SPECT. However, current procedures are costly, invasive, and qualitative. Here we applied a novel iVas-MRI technique that provides quantitative assessment of multiple hemodynamic parameters in a single scan of 9 minutes, and examined its sensitivity and specificity in predicting surgical decisions. Our results showed that iVas-MRI has an overall accuracy of 0.93 in predicting surgical decisions in MMD. |
| 373 | 9:15
|
Baseline Risk Factors Suggestive of Advanced Vascular Disease Predict Differences in Brain CBF Changes After Carotid Revascularization Surgery |
1HMS / BIDMC, Boston, MA, United States, 2TUFTS Medical School, Boston, MA, United States, 3SUNY Binghamton, Binghamton, NY, United States, 4Stanford School of Medicine, Stanford, CA, United States, 5University of Arizona, Tucson, AZ, United States |
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Carotid stenosis is a risk factor for stroke. A number of risk factors are associated with stroke. Our work shows specific risk factors that predict differences in brain perfusion using ASL MRI technique after carotid revascularization surgery. Specifically elevated systolic blood pressure, chronic renal insufficiency, and history of prior stroke have mpacts on initial baseline to immediately post surgery prefusion increase, and baseline elevated cholesterol and body mass index show differences in 1 day to 6 months post operation. This is in contrast to hypertension, smoking and diabetes, which did not show significant predict relationships. Our work suggests that these risk factors may be more closely related to cerebrovascular dysfunction. |
| 374 | 9:27
|
Clinical Feasibility Study of an Accelerated 3D Intracranial Magnetic Resonance Angiography Using Compressed-Sensing Algorithm |
1Department of Radiology, Peking University First Hospital, Beijing, China, 2Philips Healthcare, Beijing, China |
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Accelerated 3D intracranial magnetic resonance angiography(MRA) using Compressed-Sensing algorithm could be clinically valuable not only for improving the image quality and having almost the same diagnostic performance compared to conventional intracranial MRA, but also for reducing the scanning time which could improve the overall workflow of MRA imaging. It is a feasible protocol in intracranial MRA imaging. |
| 375 | 9:39
|
Multiscale multimodal imaging of the mouse cerebral vascular architecture. |
1Bio-imaging Lab, University of Antwerp, Wilrijk, Belgium, 2Laboratory of Cell Biology and Histology, University of Antwerp, Wilrijk, Belgium, 3Molecular Imaging Center Antwerp, University of Antwerp, Wilrijk, Belgium |
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We present a multiscale multimodal atlas of the mouse cerebral vasculature co-registered to the Allen Brain atlas space. To this end, we combined MRI anatomical imaging with the macro vasculature detected with TOF-MRA as well as the micro vasculature acquired from 3D microscopic imaging of a cleared mouse brain. To achieve a better homogeneity, we used a double labeling of the vasculature using isolectin to stain the vascular wall combined with an albumin staining of the blood vessel lumen. The atlas provides a reference space across multiple imaging modalities and a link to other functional, anatomical and genetic information. |
| 376 | 9:51
|
Hybrid Vessel Centerline Tracking: Towards Automated Lesion Analysis on 3D Intracranial Vessel Wall MR |
1Cedars Sinai Medical Center, Los Angeles, CA, United States, 2Tsinghua University, Beijing, China, 3Beihang University, Beijing, China, 4Xuanwu Hospital, Beijing, China |
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We proposed a hybrid vessel centerline tracking method on 3D intracranial vessel wall MR. TOF MRA was used as a complementary modality that provides additional information for potential vessel path extraction. Results show high agreement of results from the proposed method and manual rater. |
| 377
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10:03
|
Three Dimensional Intra- and Extra-cranial Arterial Vessel Wall Joint Imaging in Patients with ischemic stroke |
1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, shenzhen, China, 2XinJiang Medical University, Urumchi, China, 3Department of Radiology, Chinese PLA General Hospital, Beijing, China |
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Intracranial and carotid atherosclerotic plaques are responsible for about 75% of ischemic stroke, the leading cause of mortality and morbidity worldwide. A 3D intra- and extra-cranial arterial vessel wall joint imaging was developed for simultaneously evaluating intracranial and carotid arterial plaques. The aim of this study was to assess the clinical potential of the 3D joint imaging technique in a large-scale patients with recent cerebrovascular symptoms. In general, this joint imaging method allows satisfactory image quality and comprehensive evaluation of atherosclerotic disease, and it has great potential to be used for optimizing treatment. |
| N03 | Tuesday 8:15 - 10:15 | Moderators: Daniel Gallichan & Jana Hutter |
| 378
|
8:15
|
Chirp-Encoded 3D GRE and MPRAGE sequences |
1Monash Biomedical Imaging, Monash University, Melbourne, Australia, 2School of Psychological Sciences, Monash University, Melbourne, Australia, 3Department of Electrical and Computer System Engineering, Monash University, Melbourne, Australia, 4School of Software and Electrical Engineering, Swinburne University of Technology, Melbourne, Australia, 5Institute of Medicine, Research Centre Juelich, Juelich, Germany |
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Non-Fourier encoding such as random, noiselets and chirp encoding have demonstrated image quality improvement in accelerated compressive sensing (CS) MRI applications. However, implementation of the non-Fourier encoding schemes in 2D spin echo sequence limits its use in practice, due to the fact that spin echo is inherently a slow sequence. In this work, we present a novel implementation of chirp encoding in fast 3D gradient echo (GRE) and MPRAGE sequences. The chirp encoding scheme is compared with conventional Fourier encoding for compressive sensing and susceptibility weighted imaging applications. The evaluation demonstrates that chirp encoding is able to preserve spatial resolution better than the Fourier encoding. |
| 379 | 8:27
|
Three Vencs for the Price of Two: Efficient Multi-Venc Phase-Contrast MRI for Improved Velocity Dynamic Range |
1Department of Radiology, Northwestern University, Chicago, IL, United States, 2Department of Biomedical Engineering, Northwestern University, Evanston, IL, United States, 3Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc., Chicago, IL, United States, 4Philips Healthcare, Gainesville, FL, United States |
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Single-venc 4D flow MRI is inherently limited by the need to set a velocity encoding sensitivity (venc), where velocity(v)>venc results in velocity aliasing and v<<venc results in elevated noise. Thus, we propose a novel multi-venc encoding scheme for reconstruction of a triple-venc 4D flow dataset from our previously described 7TR dual-venc sequence. This triple-venc dataset can be used to improve velocity unwrapping without increasing scan time. The aim of this study was to systematically evaluate the utility of 7TR triple-venc velocity encoding to improve velocity dynamic range and further decrease velocity noise beyond the capabilities of current dual-venc methods. |
| 380 | 8:39
|
Single-scan multi-spin-echo SPEN for dynamic T2 mapping and for 3D T2 weighted anatomical imaging |
1Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel |
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SPatiotemporal ENcoding (SPEN) provides single-shot 2D images free from T2* effects, and with enhanced robustness to field distortions. SPEN’s acquisition module is relatively short, opening the possibility to combine SPEN with a multi-spin-echo protocol, thus collecting several images in one shot. This work explores this possibility towards two different aims: the single-shot characterization of spatially-resolved T2 maps, and the accelerated acquisition of 3D images incorporating a phase encoding. Both approaches proved successful, as exemplified with real-time T2 mapping of in vivo kidney on a perfused mouse and high resolution volumetric acquisitions on ex vivo phantoms and human volunteers. |
| 381 | 8:51
|
Fast imaging with ultrahigh isotropic resolution using partition-encoded simultaneous multi-slab (PRISM) |
1BRIC, UNC at Chapel Hill, Chapel Hill, NC, United States |
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Fast imaging with ultrahigh isotropic resolution has gained widespread interests but is technically challenging. The simultaneous multi-slice (SMS) and 3D imaging can hardly achieve high isotropic resolution without compromising temporal resolution or imaging contrast that needs long TR. A novel method, Partition-encoded Simultaneous Multi-slab (PRISM) imaging, was proposed to mitigate the physical constraints of thin slice excitation by applying partition encoding onto simultaneous multi-slab acquisition and provide ultrahigh isotropic resolution while maintaining the acceleration capability and TR flexibility. Using the PRISM technique, whole-brain fMRI with spatial resolution of 1mm isotropic and a temporal resolution of 2 seconds has been achieved. |
| 382 | 9:03
|
Faster T2 Shuffling with Wave-encoding |
1Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Department of Electrical Enginerring and Computer Science, Massachussets Institute of Technology, Cambridge, MA, United States |
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T2-shuffling is a recently proposed approach that can reconstruct multiple, sharp T2-weighted images from a single fast spin-echo (FSE) scan. Wave-CAIPI is a parallel imaging technique that uses additional sinusoidal gradients to spread aliasing in the readout direction, to take full advantage of coil-sensitivity information in highly accelerated rectilinear acquisitions. In this work, we augment T2-shuffling with wave-encoding and examine the ability of this combined approach in accelerating FSE acquisition that can achieve multiple T2-weighted images reconstruction. We demonstrate the efficacy of our technique through a 2D simulation, where wave-encoding was shown to provide good reconstruction at 2-3x higher accelerations. |
| 383 | 9:15
|
Highspeed Imaging with Sub-millisecond Temporal Resolution of the Vocal Folds Oscillations using EGG-Gated Gradient Echo with Rapid Phase Encoding |
1Dept.of Radiology, Medical Physics, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 2German Consortium for Translational Cancer Research Freiburg Site, German Cancer Research Center (DKFZ), Heidelberg, Germany, 3Institute of Musicians' Medicine, Freiburg University Medical Center, Germany Faculty of Medicine, University of Freiburg, Freiburg, Germany |
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We present a novel encoding method that allows sampling of one-dimensional periodic motion with sub-millisecond time resolution by applying very short phase encoding gradients along the direction of motion. The technique is applied to the oscillatory motion of the vocal folds during singing, and MR data are gated using an electroglottography synchronisation signal. Dynamic images during vocal fold oscillation were acquired with a temporal resolution of about 690 µs, and closing of the vocal folds was assessed. |
| 384 | 9:27
|
Synthetic MP2RAGE: multiple ‘on-demand’ contrasts from a single acquisition |
1Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 3Siemens Healthcare SAS, Saint-Denis, France, 4Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 5Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, 6Signal Processing Laboratory (LTS 5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland |
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MP2RAGE and FLAWS sequences are increasingly used for brain clinical research imaging at ultra-high field. Yet, the ability to provide at the same time an optimal contrast between GM and WM for segmentation, an accurate T1 mapping and/or the ability to highlight only a single tissue or lesions, is in practice not possible with only one single MP2RAGE acquisition. In this work, we demonstrate that synthetic ‘uniform’ images with ‘on-demand’ clinically relevant contrasts could be generated at 7T from a single MP2RAGE acquisition providing an accurate T1 map, allowing for instance tissue signal nulling or lesion signal enhancement. |
| 385
|
9:39
|
Interleaved SPEN with per-shot correction for high definition human DTI measurements |
1Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel |
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Sub-mm DTI is of great interest for clinical diagnosis and healthy tissue studies. Segmented imaging is hindered in these applications, due to complications associated to unavoidable motions in-between shots. This work demonstrates the advantages resulting from using interleaved, segmented SPatially ENcoded (SPEN) methods for DTI, thanks to their ability to (i) provide low-resolution but fully sampled images per shot; (ii) compensate for rigid-body motions by simple phase corrections, and (iii) zoom on restricted FOVs without folding complications. All this enables high-resolution diffusion MRI on humans, as shown here by delineating the pons anatomy at a 0.74mm in-plane resolution. |
| 386 | 9:51
|
Parallel Transmit Excitation Pulses for Shuttered Echo Planar Imaging |
1Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 3Radiology, Vanderbilt University, Nashville, TN, United States |
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A parallel transmission based shutter excitation is proposed for multishot EPI that overcomes its sensitivity to motion and dynamic phase changes between shots. The g-factor performance, flip angle error, and SAR are characterized as a function of the number of transmit coils, and compared to ideal single-channel excitation. |
| 387 | 10:03
|
An Optimized 3D Stack-of-Stars TSE Pulse Sequence for Simultaneous T2-weighted Imaging and T2 Mapping |
1Electrical and Computer Engineering, University of Arizona, Tucson, AZ, United States, 2Medical Imaging, University of Arizona, Tucson, AZ, United States, 3Siemens Healthcare, Tucson, AZ, United States, 4Department of Surgery, University of Arizona, Tucson, AZ, United States, 5Biomedical Engineering, University of Arizona, Tucson, AZ, United States |
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A 3D stack-of-stars Turbo Spin Echo sequence is presented for efficient T2-weighted imaging and T2 mapping. The pulse sequence parameters are optimized for T2 estimation, SNR, and SAR and the view ordering is designed to enable efficient k-space coverage for both non-selective and slab selective acquisitions. The technique provides excellent anatomical coverage within clinically acceptable times. Utility of the sequence is demonstrated in vivo on the knee, brain and for carotid vessel wall imaging. |
| N04 | Tuesday 8:15 - 10:15 | Moderators: David Norris & Rosa Sanchez Panchuelo |
| 388
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8:15
|
Functional Mapping of Body Part Representations across Layers and Columns in Humans |
1SFIM, NIMH, Bethesda, MD, United States, 2University of Glasgow, Glasgow, United Kingdom, 3NIMH, Bethesda, MD, United States, 4MBIC, Maastricht, Netherlands |
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In this work, we seek to characterize the mesoscopic circuitry of the sensorimotor system across layers, columns and brain areas. We use a blood volume and BOLD signal sensitive fMRI methodology during task and rest with 0.78 mm resolution. We find ‘columnar’-dependent connectivity, representing the same body parts (e.g. digits) across different sensory and motor areas. In the hand knob, we find ‘columnar’ networks with a finer spatial scale than the regime of individual digit representations. Layer-dependent differences of task-induced and resting-state fMRI are indicative of different input-output-driven activity. |
| 389
|
8:27
|
Cortical depth dependent resting state fMRI with motion correction |
1Dept. of Radiology, Medical Physics, Medical Center University of Freiburg, Faculty of Medicine, Freiburg, Germany, 2Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, 3Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland |
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We used |
| 390 | 8:39
|
Improved spatial specificity of the early positive BOLD response observed with high-resolution fMRI at 3T |
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States, 3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States |
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Previous studies have demonstrated improved spatial specificity of conventional BOLD fMRI when restricting the analysis to the initial dip, however recent evidence suggests that it may be possible to achieve high specificity by restricting the analysis to the early phase of the response. Here we tested this concept by employing a spatial resolution test pattern in the visual cortex and observed the evolution of this pattern over time in signal subjects. We find that the spatial pattern of the early stages of the BOLD response appear to exhibit improved spatial specificity. |
| 391 | 8:51
|
Columnar processing of acoustic features in human auditory cortex |
1Maastricht Centre for Systems Biology, Maastricht University, Maastricht, Netherlands, 2Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands, 3Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States |
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Using ultra-high field fMRI, we explored the cortical depth dependent stability of acoustic feature preference in human auditory cortex. In accordance with results from invasive recordings in cat auditory cortex, we observed a relatively stable (i.e., columnar) tuning to frequency and temporal modulations, while spectral modulation tuning was less stable throughout the cortical depth. This could represent simpler spectral tuning in middle auditory cortical layers, compared to more complex spectral tuning superficially. Furthermore, results suggest a coding strategy in which tuning to some features is kept stable orthogonal to the cortex, while tuning to other features systematically varies. |
| 392 | 9:03
|
Cortical feedback to superficial layers of V1 contains predictive scene information. |
1Institute of Neuroscience & Psychology, University of Glasgow, Glasgow, United Kingdom, 2Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands |
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A central characteristic of brain function is the ability to merge sensory input with internal representations of the world, but relatively little is known about cortical feedback channels that facilitate internal representations. We blocked feedforward input to subsections of human primary visual cortex by occluding one quarter of the visual field while participants viewed 384 real-world scenes. Using high-resolution 7T fMRI, we show that superficial layers of V1 exhibit predictive response properties unique from those associated with V1 feedforward processing. Our findings suggest that feedback to superficial layers of V1 provides neurons with contextual information not available via feedforward input. |
| 393 | 9:15
|
Depth-dependent functional mapping of mental prediction in human somatosensory cortex |
1SFIM, NIMH, Bethesda, MD, United States, 2Cognitive Neuroscience Lab, Division of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan |
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High-resolution, cortical depth-dependent fMRI allows researchers to address questions about the feed-forward and feed-back driven activity non-invasively. The processing of finger-touching in the sensory cortex is a complex interplay between feed-forward activity from the thalamus and feed-back input from higher-order brain areas representing touching anticipation/prediction. Here we use high-resolution (0.7mm) fMRI at 7T to investigate this interplay in the human brain with BOLD and blood-volume-sensitive fMRI as a function of cortical depth. We find that we can reveal that prediction input in S1 is dominated from superficial layers, while thalamo-cortical feed-forward input is dominant in middle cortical layers, as expected from previous work in animals. |
| 394
|
9:27
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True laminar resolution fMRI of the human visual cortex at 7T |
1Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands, 2Maastricht Brain Imaging Centre (MBIC), Maastricht, Netherlands |
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Current laminar BOLD fMRI studies at ultra-high field are typically carried out at sub-millimetre spatial resolution (~0.7mm isotropic), which, however, results in each voxel covering more than one cortical layer. Thus, layer-resolved activation profile can only be obtained if such data is analysed with post-processing tools at super-resolution. In this study, we demonstrate a novel functional mapping approach by acquiring fMRI data at true laminar resolution (100µm) in humans at 7T, compare it to the conventional high-resolution GE-EPI and analyse the depth-dependent BOLD signal change to visual stimulation. |
| 395 | 9:39
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The EPI rs-fMRI signal shows an orientation effect with respect to B0 and phase-encode axis across cortical depth |
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, United States, 2Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 3Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States |
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The cortex exhibits a strict vascular architecture and vessel orientation to the B0 field should impact the local susceptibility and hence the local BOLD signal. Cortical folding could thus lead to local variations in the signal. Here, we used high-resolution 7T EPI rs-fMRI data and found substantial variations of the signal amplitdude's coefficient of variation (σ/μ) with the local cortical orientation to B0. This effect was measurable throughout cortical depths with a maximised effect of +70% at the surface. We compare this to orientation-dependent blurring effects along the phase-encode axis, which we found to be significant too. |
| 396 | 9:51
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Estimating the Spatial Precision of Multivoxel Pattern of BOLD Response at 7T |
1CMRR, University of Minnesota, Minneapolis, MN, United States, 2University of Glasgow, Glasgow, United Kingdom, 3Maastricht University, Maastricht, Netherlands |
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fMRI has limited spatial accuracy due to the vascular nature of the signal source. At high fields, sub-millimeter functional images can be acquired with the hopes of investigating cortical columns and/or layers. The efforts to improve the spatial accuracy of the signals tends to be focused on the acquisition side, rather than the analysis side. Here, we explore the use of multi-voxel pattern analysis as a means to circumvent the apparent spatial specificity limits of ultra-high field fMRI. |
| 397 | 10:03
|
Hypercapnic and hyperoxic laminar calibrated BOLD: are conventional models adequate? |
1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany |
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Several sub-millimetre-resolution fMRI acquisitions have been developed in recent years, however none taken singularly directly reflects neural activity. We use a calibrated BOLD approach combining BOLD and VASO measurements with respiratory manipulations (CO2 and O2) and a motor task to estimate cortical profiles of changes in O2 metabolism, a parameter more tightly related to neuronal function. Calculated hypercapnic calibration parameters are consistent with previous findings, while physiologically implausible estimates of O2 metabolism changes are found with hyperoxic calibration. A possible reason for this is reported, which questions the validity of conventional models for hyperoxic calibration at this resolution. |
| S04 | Tuesday 8:15 - 10:15 | Moderators: Luisa Ciobanu & A. Dean Sherry |
| 398 | 8:15
|
Intracellular MEMRI signals reflect the frequency of action potentials in Aplysia neurons |
1NeuroSpin/CEA, Gif-sur-Yvette, France, 2University of Bordeaux, Bordeaux, France |
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We show a positive correlation between electrical activity and MEMRI signal intensity in identified neurons in Aplysia buccal ganglia and demonstrate that the MEMRI signal reflects mainly fast and high membrane depolarization processes such as action potentials, and it is not sensitive to slow and small membrane depolarization, such as post-synaptic potentials. |
| 399 | 8:27
|
Active Targeting of human neutrophil granulocytes by non-invasive 19F MRI |
1Heinrich-Heine University, Düsseldorf, Germany, 2Albert-Ludwigs-University, Freiburg, Germany |
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The purpose of the present study was to target human neutrophils by PFCs to enable their visualization by 19F MRI. We coupled a neutrophil-binding peptide (NG2) to PFCs and showed the specific binding and internalization of NG2-PFCs by 19F MRI, microscopy and FACS. Interestingly, NG2-PFCs show an increased labelling of neutrophils from MI patients and these cells also showed an increased migration into an artificial circulation system which contained an IL-8 doped matrigel placed in a flow chamber. In conclusion, NG2-PFCs are suited to label neutrophil granulocytes after MI and enable their non-invasive visualization by 1H/19F MRI. |
| 400
|
8:39
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Layer specific neural interactions in the thalamo-cortical and cortico-cortical networks: An optogenetic manganese-enhanced MRI study |
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China |
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The thalamo-cortical projections terminating in the primary somatosensory cortex are anatomically organized into layers. However, the functional layer-specificity of the axonal pathways which comprise the thalamo-cortical circuit remains to be studied. Combining optogenetic stimulation and manganese-enhanced MRI, the present study selectively induces neural activity in the ventral posteromedial nucleus to induce the deposit of manganese in its projections in-vivo. By identifying the cortical regions with increased contrast, using images acquired with the MDEFT MRI experiment, we infer the layer-specific connections from the thalamus to the primary somatosensory cortex. |
| 401 | 8:51
|
Noninvasive imaging of transgene expression using CEST-MRI |
1Molecular Imaging Research Center (MIRCen), Commissariat à l'Energie Atomique, Fontenay-aux-Roses, France, 2US27, Inserm, Fontenay-aux-Roses, France |
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Gene therapy often uses viral vectors to insert a therapeutic gene into cells. It is necessary to develop molecular imaging techniques to safely monitor gene expression. We designed a strategy to image expression of a transgene using a genetically engineered CEST reporter. An adeno associated vector encoding for 150 L-arginine residues fused to a fluorophore was produced and injected in the mouse brain. Specific signals were observed in both CEST and fluorescence modalities, demonstrating the possibility to use CEST-based reporter genes to monitor transgene distribution and expression. Such noninvasive imaging modality could be valuable for further developments of gene therapy. |
| 402 | 9:03
|
OATP1A1 reporter gene-enhanced magnetic resonance imaging of Triple Negative Breast Cancer in animal models at 3 Tesla |
1Medical Imaging, Robarts Research Institute, London, ON, Canada, 2Medical Biophysics, University of Western Ontario, London, ON, Canada, 3Ontario Institute for Cancer Research, Toronto, ON, Canada |
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Preclinical cancer models are invaluable for studying oncogenic pathways and assessing therapies. However, precise detection of small tumours with specificity, sensitivity and high resolution remains challenging. A member of the Organic Anion Transporting Polypeptide 1 (OATP1) family of proteins, called OATP1A1, can take up the clinically-approved, liver-specific paramagnetic agent Gd-EOB-DTPA. Significant increases in spin-lattice relaxation rates were exhibited at 3T by triple negative breast cancer (TNBC) cells engineered to express OATP1A1 and pilot data showed enhancement of OATP1A1-expressing orthotopic TNBC tumours in mice. Our data supports the utility of OATP1A1 for improved MR detection of TNBC tumours in animal models. |
| 403 | 9:15
|
MR/ fluorescence dual-modality image-guided multifunctional albumin nanoassembies for sonodynamic therapy of glioma |
1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2University of Chinese Academy of Sciences, Beijing, China, 3The First College of Clinical Medical Sciences，China Three Gorges Unversity, Yichang, China |
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Sonodynamic therapy (SDT) is a non-invasive and effective therapeutic modality for solid cancerous tumors. In this study, to improve the effectiveness of SDT, we fabricated a high-performance multifunctional albumin nanoassembies (HSA-Ce6-Mn NCs) having higher cell uptake efficiency and the tumor accumulation. It also exhibited an excellent ability of MR/ fluorescence (FL) dual-modality imaging so that glioma margin and HSA-Ce6-Mn NCs metabolism could be clearly visualized. The SDT has been demonstrated for suppressing the tumor growth in-vivo under a MRI-guided FUS system and it is highly expected to have a great potential in clinical translation. |
| 404 | 9:27
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Multimodality cellular and molecular imaging of the impact of a primary tumor on metastatic growth in a syngeneic mouse model of breast cancer brain metastasis |
1Medical Biophysics, Western University, London, ON, Canada, 2Western University, London, ON, Canada |
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The mechanisms that influence metastatic growth rates are poorly understood. One mechanism of interest known as concomitant tumor resistance (CTR) can be defined as the inhibition of metastatic growth by existing tumor mass. Conversely, the presence of a primary tumor has also been shown to increase metastatic outgrowth, termed concomitant tumor enhancement (CTE). The goal of this research was to use conventional and cellular MRI , and bioluminescence imaging to study the impact of a primary tumor on the development of breast cancer brain metastases in a syngeneic mouse model. |
| 405 | 9:39
|
Europium(2+/3+) dual mode MRI contrast agents: combining paraCEST and T1w contrast in one oxygen-sensitive agent. |
1UT Southwestern Medical Center, Dallas, TX, United States, 2University of Texas at Dallas, Dallas, TX, United States |
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The ability to determine hypoxia in tumors in vivo could provide useful diagnostic contrast information. MRI contrast agents could provide this information. Eu2+ is isoelectronic with Gd3+, and produces T1w contrast on a similar level, in addition, it is not oxidatively stable. In an aerobic atmosphere, it oxidizes rapidly to Eu3+, which does not produce T1 contrast, but can belong to a conceptually different class of contrast agents: paraCEST (chemical exchange saturation transfer) agents. A Eu2+/3+ agent was tested in different tissues in-vivo to show the correlation between the rate of oxidation and the surrounding oxidative environment of the tissue. |
| 406
|
9:51
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Renal pH Imaging Using Aspirin Analogs and CEST MRI |
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States |
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Developing new tools that can be used to detect changes in renal tissue is of great interest for nephrologists. Indeed, standard measurements of blood-urea nitrogen and serum creatinine might not detect kidney injury until a 50% loss in function occurs. As kidneys play a preeminent role in controlling acid-base balance, pH mapping should enable early detection of changes in renal health. Here we propose administration of salicylate based diaCEST MRI agents to map renal pH. As we show, aspirin and three analogs: salicylic acid, 2,4-dihydroxy benzoic acid, 2,5-dihydroxy benzoic acid displayed promise in vitro and in vivo for pH mapping. |
| 407 | 10:03
|
Development and Proof of Principle for Free Radical Imaging with the Novel Field-cycling in vivo DNP-MRI |
1Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka, Japan, 2Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan, 3Osaka University, Suita, Japan, 4University of Yamanashi, Yamanashi, Japan, 5Kinjo Gakuin University, Nagoya, Japan, 6Fuji Electric Co., Ltd, Tokyo, Japan |
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In vivo DNP-MRI was reported as a new imaging method for free radical species in vivo1, and the field-cycling was utilized to overcome the large difference between electron and nuclear spin resonances2,3. Unfortunately the development of the clinical DNP-MRI has severe difficulties due to less applicability. Here, we developed the novel field-cycling DNP-MRI for clinical trial by rotating the magnets for MRI (0.3T) and ESR (4.7mT), and the free radicals placed under the palm of volunteers were visualized, superimposed on the anatomical MRI image, and demonstrated the proof of principle for free radical imaging with the newly developed field-cycling DNP-MRI. |
| S05 | Tuesday 8:15 - 10:15 | Moderators: Xiang Xu & Greg Stanisz |
| 408
|
8:15
|
NOE-mediated CEST Imaging of Glioma at 7 Tesla Aids Early Response Evaluation of Patients Undergoing Radio-Chemotherapy |
1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Radiation Oncology, Medical Faculty, University of Heidelberg, Heidelberg, Germany, 3Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany |
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Reliable biomarkers for an early assessment of treatment response are urgently needed. In this study, we investigated the rNOE-mediated CEST signals in patients undergoing radio- and chemotherapy at three different time points including pre and post treatment. The results were compared to the standard clinical determination of responders and non-responders (RANO criteria) and the relaxation compensated CEST contrast NOEAREX showed a statistically significant difference between the two groups directly after therapy. Hence, NOEAREX might potentially help determining early tumor response to therapy. |
| 409
|
8:27
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CEST-Dixon for human breast cancer characterization at 3T: a preliminary study |
1Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3Philips Research, Hamburg, Germany |
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Previous studies have demonstrated the application of CEST to breast malignancies and its potential to aid tumor characterization. However, artifacts can develop in breast CEST imaging due to strong lipid signals. In this work, CEST-Dixon sequence is used for fat free CEST imaging to characterize suspicious lesions in patients. The CEST effects are higher in the ER- IDC than the ER+ IDC, benign and normal groups. The results also indicate positive correlation of CEST with the Ki-67 level. Thus, CEST-Dixon has a potential for improved non-invasive characterization of breast lesions, potentially differentiating more aggressive from less aggressive tumors. |
| 410
|
8:39
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Decoding IDH Genotype in Grade-II and -III Gliomas with Protein-based Amide Proton Transfer-Weighted (APTw) MRI |
1Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China, 2Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 3Department of Pathology, Zhujiang Hospital, Southern Medical University, Guangzhou, China, 4Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China |
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We explored the possibility of using the APTw signal intensity as a surrogate marker to identify IDH mutation status in gliomas. 105 patients with newly diagnosed grade-II/III gliomas were included. APTw histogram data obtained from tumor burden was recorded. The Mean, Peak, 10th, 25th, 50th, 75th, 90th Percentiles of APTw signal histograms were significantly higher in the IDH-wildtype group than in the IDH-mutant group. The classification for 50th Percentile APTw to differentiate these two glioma groups was 78.1%. Preoperative APTW imaging may assist in predicting the IDH mutation status in gliomas. |
| 411
|
8:51
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Quantifying the glucose CEST Effect in Patients with oropharyngeal squamous cell carcinoma at 3T in vivo using an oxygen challenge |
1Wellcome Centre for Integrative Neuroimaging, FMRIB, University of Oxford, Oxford, United Kingdom, 2Department of Oncology, University of Oxford, Oxford, United Kingdom, 3Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, United Kingdom, 4Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom, 5MR Applied Sciences Lab, GE Healthcare, Menlo Park, CA, United States |
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Characterizing tumor treatment response is an ongoing radiological challenge as both the anatomical and physiological characteristics of the tumor are changing as the treatment course progresses. GlucoCEST imaging may provide an avenue towards understanding the evolving tumor metabolic environment over the course of treatment. In this preliminary assessment, we show that an oxygen challenge can highlight changes in the vasculature of tumors post radiotherapy. |
| 412 | 9:03
|
Amide proton transfer (APT) imaging of benign ovarian cystic lesions |
1Department of Clinical Radiology, Kyushu University, Fukuoka, Japan, 2Department of Obstetrics and Gynecology, Kyushu University, Fukuoka, Japan, 3Philips Research, Hamburg, Germany |
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It is important to diagnose benign ovarian cystic lesions as early and correctly as possible because some types of lesions have malignant potential. The objective of our study is to investigate whether amide proton transfer (APT) imaging is useful for evaluation of benign ovarian cystic lesions. We compared the APT signal in three different benign ovarian cystic lesions using three different durations of presaturation pulse. |
| 413
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9:15
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Separation of the contribution of protein concentration and pH to measured APT signal changes in a preclinical model of brain metastases |
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2CRUK & MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom, 3Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom |
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Amide proton transfer (APT) studies usually attribute the altered APT signal in tumours to an increased cytosolic protein concentration. However, other concomitant changes in pH, T1, or water content make absolute quantification of protein concentration or pH from APT signals challenging. In this study, we separate the contributions of protein concentration and pH to APT signal differences in a preclinical model of brain metastases by combining in vivo and ex vivo measurements. We show that 66% of the observed APT signal difference was caused by protein concentration alterations, with the remaining 34% signal change reflecting an increase in tumour pH. |
| 414
|
9:27
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Deep CEST MRI – 9.4T spectral super-resolution from 3T CEST MRI data |
1High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2X, Mountain View, CA, United States, 3Diagnostic & Interventional Neuroradiology, University Hospital Tuebingen, Tuebingen, Germany |
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CEST peaks are easy to detect at ultra-high-field strengths due to high signal and spectral separation. However, spectral coalescence and line broadening makes modeling of CEST effects at clinical field strengths (<=3T) a challenge. In this proof-of-concept study of super-resolution CEST imaging, the underlying spectral features of 3T Z-spectra were predicted using a neural network trained on 9.4T data. Applying the neural network to untrained volunteer and patient data acquired at 3T resulted in the expected contrast in healthy gray and white matter and tumor tissue in Z-spectra and APT, NOE, and MT CEST maps. |
| 415 | 9:39
|
NaSA-CEST: MR monitoring of brain inflammation using an aspirin metabolite as contrast agent |
1Johns Hopkins Univeristy, Baltimore, MD, United States, 2Northwest University, Xi'an, Shaanxi, China, 3Xi'an Jiaotong University, Xi'an, Shaanxi, China |
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Sodium salicylate (NaSA), a nonsteroidal anti-inflammatory drug and the main metabolite of aspirin, can accumulate specifically in inflamed tissue. We investigated the use of NaSA-enhanced CEST MRI for in vivo mapping of brain inflammation, induced by intrastriatal injection of lipopolysaccharide (LPS). Inflamed mice exhibited an increase of ~8% NaSA-CEST signal on the AUC10-30min images, with signals for the ipsilateral striatum significantly higher than those for the mirrored contralateral regions. While for the non-inflamed sham mice, which received saline instead of LPS, no such NaSA-CEST signal could be observed. Our NaSA-CEST approach could possibly lead to the development of inflammation-specific theranostics. |
| 416
|
9:51
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Multicolor metabolic quantitative CEST (mmqCEST) imaging: possibility and limitations |
1UMC Utrecht, Utrecht, Netherlands, 2University of Nottingham, Nottingham, United Kingdom, 3Copenhagen University Hospital Hvidovre, Copenhagen, Denmark |
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Multicolor metabolic CEST imaging: possibility and limitations |
| 417
|
10:03
|
CEST Fingerprinting: Initial Study in Human Subjects |
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China, 3Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States |
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CEST fingerprinting was recently proposed to achieve efficient exchange rate quantification for pH mapping. Here we present the initial data of pH mapping in healthy subjects and one acute stroke patient at clinical scanners in an 8-min scan using CEST fingerprinting. The pH maps of the healthy volunteers are homogenous and the values fall in the normal physiological range. The pH map in the patient shows an inhomogenous acidic area. This study shows CEST fingerprinting has the potential to detect acidosis in human subjects. |
| W05/06 | Tuesday 8:15 - 10:15 | Moderators: Shigeki Aoki & Dorothee Auer |
| 418
|
8:15
|
Exploring Temporal Dynamics in Resting-State Networks using Co-Activation Pattern Analysis |
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2Barrow Neurological Institute, Phoenix, AZ, United States, 3University of Colorado, Boulder, CO, United States |
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We propose a novel group CAP analysis method to investigate temporal dynamics of specific resting-state networks. Our data-driven method computes less spatially overlapping d-CAPs for each group. We compare network-dynamics between different populations using d-CAP based measurements. Using simulation, we demonstrate that the proposed method is able to determine spatially less overlapping d-CAPs for each group accurately. Using real fMRI data, we find reduced network-dynamics of most networks in PD subjects as hypothesized, which corroborates and expands upon previous electrophysiologic reports. |
| 419 | 8:27
|
Findings from SNAP-MRA and PCASL in Patients with Parkinson’s Disease “OFF” and “ON” Levodopa |
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2Tsinghua University Yuquan Hospital, Beijing, China, 3Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China |
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This study aimed to evaluate the effect of levodopa on cerebral arteries and gray matter cerebral blood flow (CBF) in patients with Parkinson’s disease (PD). We scanned 33 PD patients with “OFF” and “ON” levodopa using Simultaneous Non-Contrast Angiography and intraPlaque Hemorrhage (SNAP) MRA and Pseudo-Continuous Arterial Spin Labeling (PCASL), and used multiple statistical methods to analyze the data. Results from the statistical analysis show that after taking levodopa, patient’s treatment outcomes are highly correlated with his/her gray matter CBF. The results also suggest that levodopa can dilate cerebral arteries and improve CBF, but only in patients with mild symptoms. |
| 420 | 8:39
|
Functional MRI can distinguish between optimal and non-optimal frequencies in PD-DBS |
1GE Global Research, Bangalore, India, 2Department of Neuroscience and Experimental Therapeutics, Albany Medical Center, Albany, NY, United States, 3GE Global Research, Niskayuna, NY, United States, 4Department of Neurosurgery, Albany Medical Center, Albany, NY, United States |
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Deep Brain Stimulation is an effective treatment for Parkinson's disease symptoms. Despite its success, the underlying principle and the mechanisms are not yet fully understood. In this study, we recorded concurrent DBS-fMRI to 1) elucidate brain regions activated at the clinically optimal settings and, 2) determine the effect of changes in stimulation frequency on whole-brain activation. Optimal DBS frequencies showed activation in the thalamus and motor cortices. Further, there was a significant difference in activation in the sensorimotor cortices between the optimal and non-optimal frequencies, indicating potential use for fMRI as a tool for optimizing DBS parameters. |
| 421 | 8:51
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Early Stage Parkinson’s Disease Shows Changes in Energy and Period Content of Resting-State Networks |
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of Colorado, Boulder, CO, United States, 3University of Management & Technology, Lahore, Pakistan |
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Low-frequency BOLD fluctuations of major resting-state networks in early Parkinson’s disease (PD) were studied and compared with matched normal controls. Empirical Mode Decomposition (EMD) was used to decompose the natural occurring frequency bands of major brain resting-state networks. The novelty of our approach lies in the data-adaptive decomposition of fMRI data using EMD, and identification of resting-state networks based on energy and period (inverse frequency) characteristics of intrinsic mode functions. For most networks studied that showed a large effect size, the frequency content of the associated network time series was found to be significantly reduced in PD. |
| 422 | 9:03
|
Resting state functional corticostriatal connectivity in Parkinsonian monkeys |
1Center for Life Science Technologies, RIKEN, Kobe, Japan, 2Okayama University, Okayama, Japan, 3Kyoto University, Kyoto, Japan, 4Department of Neuroscience, Washington University, St. Louis, MO, United States, 5St. Luke's hospital, St. Louis, MO, United States |
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Studies in animal models of Parkinson’s disease have established that excessive synchronization of neuronal activity in basal ganglia cortical loops is the hallmark of movement disorders in Parkinson’s disease. However, majority of the studies have focused on basal ganglia and motor areas in Parkinson’s disease models and it is still unclear how dopamine denervation influences other neocortical areas, which each exhibit distinct corticostriatal and thalamocortical connectivity profiles. To address this issue, we investigate the effects of dopaminergic neuronal loss on functional connectome using resting-state fMRI in anesthetized MPTP-treated monkeys. |
| 423
|
9:15
|
MR imaging of neuromelanin-iron cluster within human postmortem substantia nigra |
1Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea, 2Department of Anatomy, Pusan National University School of Medicine, Yangsan, Republic of Korea, 3Department of Electrical and Computer Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea, 4Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea |
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The overall goal of this work was to provide a truth of neuromelanin-sensitive T1 weighted image with magnetization transfer effects and to segment the respective distribution of neuromelanin-iron complex and ferric iron within substantia nigra which are important to monitor Parkinson’s disease. Postmortem MR experiment at 7T and histological validation were performed for six normal midbrain samples. The correlation between T2*/T2 and neuromelanin pigments was highest compared to other MR parameters, especially compared to T2*, which shows specific distributions of paramagnetic molecules. Iron deposits were highly correlated with iron-sensitive T2 and T2* and the correlation was reduced for T2*/T2. |
| 424 | 9:27
|
Lateral-ventral tier nigral iron deposition and neuromelanin depletion in Parkinson's disease |
1Center for Advanced Neuroimaging, University of California Riverside, Riverside, CA, United States, 2Department of Neurology, Emory University, Atlanta, GA, United States, 3Department of Bioengineering, University of California Riverside, Riverside, CA, United States |
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The substantia nigra, a neuromelanin containing structure in the brainstem, contains a dense distribution of dopaminergic neurons which undergo degeneration in Parkinson’s disease. In this abstract, we examine spatial locations of neuromelanin depletion and iron deposition in the substantia nigra after onset of Parkinson’s disease. We found the lateral-ventral tier of substantia nigra to exhibit significant neuromelanin depletion whereas iron deposition was observed across the entire substantia nigra. These results accord with prior histological studies examining substantia nigra neuronal loss and may offer insight into the mechanisms behind this loss. |
| 425
|
9:39
|
Fractional Anisotropy Within the Subthalamic Nucleus: An Imaging Biomarker for Early Parkinson’s Disease? A High-Resolution 7Tesla Magnetic Resonance Imaging Study |
1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2Neurology, University of Minnesota, Minneapolis, MN, United States |
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In this study, we used high-resolution 7Tesla MRI to study whether subthalamic nucleus (STN) characteristics, such as volume and fractional anisotropy (FA), can be used as a biomarker for Parkinson’s Disease (PD). 7Tesla MRI data were acquired for twenty-nine PD patients and twenty-one controls. Right STN volume was significantly lower in PD patients and it was negatively correlated with the UPDRS motor score. The PD group also had significantly decreased FA values in bilateral STN. To our knowledge, this is the first study to report differences in volume and FA of the STN between people with PD and controls. |
| 426 | 9:51
|
Disrupted Cortical and Subcortical Effective Connectivity in Early Parkinson’s Disease (PD): Insights from Parkinson’s Progressive Markers Initiative (PPMI) dataset |
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of Colorado Boulder, Boulder, CO, United States |
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This study utilized resting-state fMRI data to evaluate effective (directional) connectivity in newly diagnosed unmedicated patients with early PD to derive a comprehensive picture of the nature of cortico–striatal–thalamic loop connectivity in PD. We found decreased effective connectivity between the key areas in the cortico–striatal–thalamic loops in unmedicated early stage PD patients . These results were mostly lateralized to the hemisphere opposite the predominant side of parkinsonian symtoms. The findings of this study are mainly important, given the fact that, looking at changes in effective connectivity and its relation to different disease related factors may help us better understand the heterogeneity of PD and more accurately target therapeutic interventions (i.e. deep brain stimulation). |
| 427 | 10:03
|
Role of hippocampus in genesis of visual hallucinations in Parkinson’s disease: Insights from hippocampal sub-volumetry analysis |
1Neurology, NIMHANS, Bengaluru, India, 2Symbiosis International University, Pune, India, 3NIMHANS, Bengaluru, India, 4Department of Electronics, Symbiosis Institute of Technology, Symbiosis International University, Pune, India |
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The neurobiological underpinnings of psychosis, manifested through visual hallucinations (VH) in Parkinson’s disease (PD), are not fully elucidated, however, are linked to memory impairment and are associated with alterations in the hippocampus. To obtain profound understanding of the role of hippocampus in VH, a hippocampal subfield volumetric analysis on PD patients with (PD-P) and without psychosis (PD-NP) and healthy controls (HC) was performed. The results demonstrated a clear pattern with lowest volumes in PD-P, followed by PD-NP and the highest in HCs in several subfields. Moreover, the PD-P volumes in multiple sub-fields highly correlated with memory and attention scores. |
| W07 | Tuesday 9:15 - 10:15 | (no CME credit) |
| W08 | Tuesday 9:15 - 10:15 | (no CME credit) |
| Plenary Hall (Paris Room) | Tuesday 10:45 - 11:15 |
| 10:45 | When Fast Is Not Fast Enough: The Challenging Path Towards Pediatric MRI Without Anesthesia |
Organizers: Fernando Boada, Tim Leiner, Chunlei Liu, Stephan Maier, Daniel Sodickson
| Plenary Hall (Paris Room) | Tuesday 11:15 - 12:15 | Moderators: Fernando Boada & Chunlei Liu |
| 11:15 | Image Interpretation |
1Radboud University, Netherlands |
| 11:30 | Image Acquisition & Reconstruction |
1Philips Research Hamburg, Germany |
| 11:45 | Questioning Dogmas of the Imaging Process |
1Dept. of Radiology, Medical Physics, University Medical Centre Freiburg, Freiburg, Germany |
| 12:00 | Data Platforms & Architecture |
1NYU School of Medicine, United States |
| 12:15 | Adjournment |
| Plenary Hall (Paris Room) | Tuesday 12:30 - 13:30 | (no CME credit) |
| Exhibition Hall 1689-1736 | Tuesday 13:45 - 15:45 | (no CME credit) |
| Exhibition Hall | Tuesday 13:45 - 14:45 | (no CME credit) |
| Exhibition Hall | Tuesday 13:45 - 14:45 | (no CME credit) |
| Exhibition Hall | Tuesday 13:45 - 14:45 | (no CME credit) |
| W07 | Tuesday 13:45 - 14:45 | (no CME credit) |
Organizers: Kamil Uludag, Essa Yacoub
| N04 | Tuesday 13:45 - 15:45 | (no CME credit) |
13:45
|
Laminar Neural Recordings with Electrophysiology | |
14:15
|
Acquisition Methods for Laminar fMRI | |
14:45
|
Data Analysis for Laminar fMRI | |
1Massachusetts General Hospital, United States |
15:15
|
Modeling Vascular Bias in Laminar fMRI | |
Organizers: Eric Ahrens, Ulrich Flögel
| W05/06 | Tuesday 13:45 - 15:45 | (no CME credit) |
13:45
|
19F MRI for Inflammation & Cytotherapy Detection in Cancer | |
1Robarts Research Institute, Canada |
14:05
|
Optimized Pulse Sequence Design for 19F MRI | |
1Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland |
14:25
|
Fluorinated Gas MRI for Structural & Functional Imaging of the Airways | |
1Lakehead University |
14:45
|
Boosting 19F MRI Sensitivity by Hyperpolarization | |
1Institute for Biometry and Medical Informatics, Otto-von-Guericke University Magdeburg, Medicinal Faculty, Magdeburg, Germany |
15:05
|
Tracking Immunotherapeutic T Cells Using 19F MRI | |
15:25
|
Translating 19F MR Inflammation Imaging to the Clinical Setting | |
Organizers: Elena Kaye, Viola Rieke
| N01 | Tuesday 13:45 - 15:45 | Moderators: Valentina Giannini & Elizabeth Sutton |
13:45
|
Radiomics in MRI: Getting Started | |
1Laboratoire de Traitement de l'Information Médicale (LaTIM - INSERM UMR 1101), Brest, France |
||
Better standardization, transparency and sharing practices are required in the radiomics community to improve the quality and reproducibility of published studies and to achieve faster clinical translation. In this course, emphasis will be put on the presentation of the standardized radiomics workflow defined by the Image Biomarker Standardisation Initiative (IBSI), a group of more than 55 researchers from 19 institutions in 8 countries. Since 2016, the IBSI has put efforts into standardizing both the computation of radiomics features and the image-processing steps required before feature extraction. This standardized workflow along with consensual benchmark values could serve as a calibration tool for future radiomics investigations. Finally, radiomics methods specific to MRI will also be presented in this course. |
14:45
|
MR-Radiomics in Oncology | |
1University of Texas, United States |
15:45
|
Adjournment & Meet the Teachers |
Organizers: Gregor Adriany, Christoph Juchem, Mary McDougall, Gregory Metzger
| N02 | Tuesday 13:45 - 15:45 | Moderators: Samantha By & Christoph Juchem |
13:45
|
Ultrahigh Fields: What You Want & What You Don't | |
1Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, United States |
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Since the introduction of the first 7 Tesla system in 1999, steady improvements in instrumentation and ever expanding armamentarium of image acquisition and engineering solutions to challenges posed by ultrahigh fields (UHF) has brought UHF imaging to exquisite anatomical detail and biological information content in many organ systems of the human body. However, like all technologies, magnetic resonance applications at UHF have applications-specific advantages and limitations. This lecture will aim to clarify the primary advantages that we should exploit (“what we want”), while avoiding some of the pitfalls that detract from these advantages (“what you don’t want”). |
14:15
|
System Requirements Beyond 3T | |
1Centre for Image Sciences, University Medical Center Utrecht, Netherlands |
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This educational reviews the system requirements of a modern ultra high field MR system. It describes magnetic and gradient specifications and discusses in more depth RF challenges and solutions for successful UHF MR imaging. |
14:45
|
Getting What You Want: Managing the Mayhem | |
1CMRR - University of Minnesota, United States |
||
In this educational lecture, we will review possible strategies that can be used to manage the mayhem of RF non-uniformity and SAR, the two major challenges at ultrahigh field. Specifically, we will start with a brief discussion as to what is possible on a standard system and will then focus on what is possible when parallel transmission is available. In particular, we will discuss the various forms of parallel transmission alongside their demonstrated utility for brain and body imaging at 7 Tesla and above. We will also explain how parallel transmission can be used to reduce or manage SAR. In the end, we will summarize what is learned and will discuss other aspects of parallel transmission that are not covered in this lecture. |
15:15
|
The Payoff for the Pain | |
1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Erwin L. Hahn Institute for MRI, University of Duisburg-Essen, Essen, Germany |
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This presentation will emphasize some clinical and scientific applications in human ultra-high field MR that particularly benefit from the changing physical characteristics at high magnetic fields, including susceptibility-weighted imaging and phase contrast techniques, imaging with X-nuclei, MR spectroscopy, and CEST imaging. |
15:45
|
Adjournment & Meet the Teachers |
| Power Pitch Theater A - Exhibition Hall | Tuesday 13:45 - 14:45 | Moderators: Marco Palombo & Leslie Ying | (no CME credit) |
| 428
|
13:45
|
Deep Learning Method for Non-Cartesian Off-resonance Artifact Correction |
1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States |
| 429 | 13:45
|
Gibbs-Ringing Artifact Reduction in MRI via Machine Learning Using Convolutional Neural Network |
1Guangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, Guangzhou, China, 2Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, 3Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China |
| 430
|
13:45
|
Simultaneous detection and identification of MR artifact types in whole-body imaging |
1Section on Experimental Radiology, University Hospital of Tuebingen, Tuebingen, Germany, 2Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany, 3Department of Radiology, University Hospital of Tuebingen, Tuebingen, Germany |
| 431 | 13:45
|
Automatic Assessment of MR Image Quality with Deep Learning |
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2Vascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle, WA, United States |
| 432 | 13:45
|
Automatic detection of cerebral microbleeds using Susceptibility-Weighted Imaging and a 3D deep residual network |
1The UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA, United States, 2Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States |
| 433
|
13:45
|
Deep learning diffusion fingerprinting to detect brain tumour response to chemotherapy |
1Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom |
| 434 | 13:45
|
Machine learning based estimation of axonal permeability: validation on cuprizone treated in-vivo mouse model of axonal demyelination |
1Computer Science Department and Centre for Medical Imaging Computing, University College London, London, United Kingdom, 2CENIR, ICM, Paris, France, 3Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France, 4INRIA, Université Côte d'Azur, Sophia-Antipolis, France, 5Parietal, CEA, INRIA, Saclay, France, 6AP-HP, Hôpital Saint-Antoine, Paris, France, 7Hôpital de la Pitié Salpêtrière, Sorbonne Universités, UPMC Paris 06 UMR S 1127, Inserm UMR S 1127, CNRS UMR 7225, Institut du Cerveau et de la Moelle épinière, Paris, France, 8AP-HP, Hôpital de la Pitié Salpêtrière, Paris, France |
| 435 | 13:45
|
Direct and Fast Learning of Fiber Orientation Distribution Function for Tractography |
1Center for Brain Imaging Science and Technology, Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, China, 2Department of Instrument Science & Technology, Zhejiang University, Hangzhou, China, 3MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China, 4Department of Imaging Sciences, University of Rochester, Rochester, NY, United States |
| 436 | 13:45
|
Predict the slow oscillation of the single-vessel resting-state fMRI signal of rats and humans with echo state networks |
1MPI for Biological Cybernetics, Tübingen, Germany |
| 437 | 13:45
|
Dynamic Causal Modelling with neuron firing model in Generalized Recurrent Neural Network framework |
1Department of Electrical and Computer Engineering, New York University, Brooklyn, NY, United States, 2Department of Radiology, New York University, New York, NY, United States |
| 438
|
13:45
|
AUTOmated pulse SEQuence generation (AUTOSEQ) using Bayesian reinforcement learning in an MRI physics simulation environment |
1Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Physics, Harvard University, Cambridge, MA, United States, 4Department of Biostatistics, Harvard University, Cambridge, MA, United States |
| 439 | 13:45
|
Towards a fully Automated Time-context Sensitive Convolutional Neural Network for Common Carotid Artery Lumen Segmentation on Dynamic MRI |
1Seaman Family Magnetic Resonance Research Centre, Calgary, AB, Canada, 2Medical Image Computing Lab, Campinas, Brazil |
| 440 | 13:45
|
Artificial neural networks for stiffness estimation in magnetic resonance elastography |
1Mayo Clinic, ROCHESTER, MN, United States |
| 441 | 13:45
|
MLS: Self-learned joint manifold geometry and sparsity aware framework for highly accelerated cardiac cine imaging |
1Electrical Engineering, University at Buffalo, Buffalo, NY, United States, 2Biomedical Engineering, University at Buffalo, Buffalo, NY, United States |
| 442 | 13:45
|
MoDL: Model Based Deep Learning Architecture for Image Recovery with Prior Information. |
1University of Iowa, Iowa City, IA, United States |
| Power Pitch Theater B - Exhibition Hall | Tuesday 13:45 - 14:45 | Moderators: Michael Albert Thomas & Rachel Katz-Brull | (no CME credit) |
| 443 | 13:45
|
Structural Determination Using 129Xe NMR Line-shape in Chemical Shift Imaging |
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Physiology, University of Pennsylvania, Philadelphia, PA, United States, 3Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States |
| 444 | 13:45
|
Standardisation and quantification of 23Na-MRI: repeatability and reproducibility of sodium imaging |
1Informatics, Imaging and Data Sciences, The University of Manchester, Manchester, United Kingdom, 2CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester, United Kingdom, 3Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 4Bioxydyn Ltd., Manchester, United Kingdom |
| 445 | 13:45
|
Improved Quantification of Hepatic Fatty Acid Metabolism in Nonalcoholic Steatohepatitis: Serum Biochemistry and In vivo Proton MRS Study with Spin-Spin Relaxation Time Correction at 9.4 T |
1Department of Biomedical Engineering and Research Institute of Biomedical Engineering, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea |
| 446
|
13:45
|
Assessing metabolism and function of normothermically perfused ex vivo livers by multi-nuclear MR imaging and spectroscopy |
1Oxford Centre for Clinical Magnetic Resonance Research (OCMR), University of Oxford, Oxford, United Kingdom, 2Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 3Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, 4Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, 5OrganOx Ltd, Oxford, United Kingdom, 6Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, 7Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom |
| 447 | 13:45
|
Effects of Deuteration on Pyruvate Metabolism in the Isolated Heart |
1UT Southwestern Medical Center, Dallas, TX, United States, 2University of Texas at Dallas, Richardson, TX, United States, 3Veterans Affairs North Texas Healthcare System, Dallas, TX, United States |
| 448 | 13:45
|
Oxidative stress measured by in-vivo, longitudinal 1H MRS and ex-vivo ESR spectroscopy in a rat model of chronic Hepatic Encephalopathy |
1Center for Biomedical Imaging, EPFL, Lausanne, Switzerland, 2Service of Biomedicine, CHUV, Lausanne, Switzerland, 3Swiss Center for Liver Disease in Children, Department of Pediatrics, HUG, Geneva, Switzerland, 4Laboratory of Physics of Complex Matter, EPFL, Lausanne, Switzerland |
| 449
|
13:45
|
NMR spectroscopy based blood test to diagnose brain cancer at early stages |
1Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, United States, 2Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, United States, 3Biochemistry and Cell Biology | Chemistry, Rice University, Houston, TX, United States |
| 450 | 13:45
|
Human Glioblastoma Cell Lines Co-oxidize [2,4-13C]betahydroxy-butyrate and [U-13C]-glucose: A 13C NMR Spectroscopic Study |
1Kenneth R. Peak Center, Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, United States |
| 451 | 13:45
|
Patch-based super-resolution of 7 T MRSI of Glioma: Initial results |
1High Feld MR Centre, Medical University of Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 3icometrix, R&D, Leuven, Belgium, 4Diagnostic Image Analysis Group, Radboud University Medical Center, Nijmegen, Netherlands, 5Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 6Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 7F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 8Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, 9Department of Medicine 1, Division of Oncology, Medical University of Vienna, Vienna, Austria, 10Department of Electrical Engineering-ESAT, STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium, 11BioImaging Lab, Universiteit Antwerpen, Antwerp, Belgium |
| 452
|
13:45
|
IMPORTANCE OF THE LACTATE SHUTTLE FOR BRAIN ACTIVATION: AN IN VIVO LOCALIZED 1H-MRS AND FUNCTIONAL MRI STUDY DURING WHISKER STIMULATION |
1CNRS/Université Bordeaux, Centre de Résonance Magnétique des Systèmes Biologiques UMR 5536, Bordeaux, France, Metropolitan, 2CH Lausanne, Switzerland, Département de Physiologie, Lausanne, Switzerland, 3Lausanne University Hospital, Department of Clinical Neurosciences, Laboratory of Cellular and Molecular Neurotherapies (LCMN), Lausanne, Switzerland |
| 453 | 13:45
|
Real time observation of shifts in cerebral metabolism caused by cocaine administration via MRS, DNP, and NMR |
1Box 100245, University of Florida, Gainesville, FL, United States, 2University of Florida, Gainesville, FL, United States, 3University of Colorado, Boulder, CO, United States |
| 454 | 13:45
|
Evidence for Two T2 Components of N-Acetyl-Aspartate (NAA) In Healthy White Matter |
1MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, 2UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 3ImageTech Lab, Simon Fraser University, Surrey, BC, Canada, 4Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 5International Collaboration on Repair Discoveries, Vancouver, BC, Canada, 6Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, 7Radiology, University of British Columbia, Vancouver, BC, Canada |
| 455 | 13:45
|
Elevated brain NAA occurs without loss of neuronal integrity and correlates with increasing Sickle Cell Disease related stress. |
1Radiology, Albert Einstein College of Medicine, Bronx, NY, United States, 2Hematology, Albert Einstein College of Medicine, Bronx, NY, United States, 3Physiology & Biophysics, Albert Einstein College of Medicine, Bronx, NY, United States, 4Pathology, Albert Einstein College of Medicine, Bronx, NY, United States, 5Medicine, Albert Einstein College of Medicine, Bronx, NY, United States |
| 456 | 13:45
|
Cerebral Metabolite Changes and Sleep Correlates in Obstructive Sleep Apnea |
1Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 2School of Nursing, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 3Radiological Sciences, UCLA School of Medicine, Los angeles, Los Angeles, CA, United States, 4Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 5Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States |
| 457 | 13:45
|
Cortical GABA levels correlate with visual search performance in children with autism spectrum disorder |
1School of Health Sciences, Purdue University, West Lafayette, IN, United States, 2Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 3Department of Speech, Language, & Hearing Sciences, Purdue University, West Lafayette, IN, United States |
Organizers: Edwin Oei, Jung-Ah Choi, Emily McWalter, Miika Nieminen
| S01 | Tuesday 13:45 - 15:45 | Moderators: Miika Nieminen & Jung-Ah Choi |
13:45
|
Physiology of Joint Tissues in Osteoarthritis | |
1University of Cambridge |
14:15
|
Whole Joint Imaging of Osteoarthritis with Morphological & Quantitative MRI | |
1Stanford University, Stanford, CA, United States, 2Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States |
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Imaging tools are needed to detect and stage joint status early enough in the disease process that osteoarthritis modifying interventions might have a chance. The purpose of this talk is to introduce MRI methods for morphologic and quantitative evaluation of osteoarthritis of the knee. Compositional MRI measures of OA will also be discussed. |
| 458 | 14:45
|
Three Dimensional Adiabatic T1rho Prepared Ultrashort Echo Time Cones (3D AdiabT1rho UTE-Cones) Sequence for Whole Knee Imaging |
1University of California, San Diego, San Diego, CA, United States, 2GE Healthcare, San Diego, CA, United States, 3VA San Diego Healthcare System, San Diego, CA, United States |
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To propose a combination of a three dimensional ultrashort echo time sequence employing cones trajectories with an AdiabT1rho preparation (3D AdiabT1rho UTE-Cones) for volumetric T1rho assessment of both short and long T2 tissues in the knee joint on a clinical 3T scanner. Simulation, phantom, ex vivo and in vivo studies were carried out in this feasibility study. |
| 459
|
14:57
|
Ultrashort Echo Time Imaging of the Osteochondral Junction in Subjects with Knee Osteoarthritis and Age-matched Healthy Volunteers |
1Radiology, University of Cambridge, Cambridge, United Kingdom, 2Experimental Medicine Imaging, GlaxoSmithKline, Stevenage, United Kingdom, 3GE Healthcare, Little Chalfont, United Kingdom, 4Trauma & Orthopaedics, University of Cambridge, Cambridge, United Kingdom |
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We describe in vivo translation of ultrashort TE (UTE) imaging of the osteochondral junction (OCJ) at the knee in 9 subjects with osteoarthritis (OA) and 4 age-matched healthy volunteers. The OCJ plays an important role in onset and progression of OA. Our study demonstrates that UTE imaging of the OCJ is repeatable and demonstrates OCJ defects in OA subjects but not in healthy volunteers. Areas of OCJ damage commonly co-locate to other osteochondral pathology (bone marrow lesions and cartilage defects). UTE imaging of the OCJ may be a helpful tool for assessing OCJ damage in clinical studies of OA. |
| 460 | 15:09
|
T1ρ and T2 of articular cartilage and medial meniscus at baseline and 6-month can predict the degenerative changes of cartilage at 3 years after ACL reconstruction |
1Biomedical Engineering, Cleveland Clinic, Cleveland, OH, United States, 2Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 3Orthopedic Surgery, University of California, San Francisco, San Francisco, CA, United States |
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Patients with anterior cruciate ligament (ACL) injury have a high risk of development of early post-traumatic osteoarthritis (PTOA) even after ACL reconstruction. The aim of this study was to investigate the risk factors that may predict the longitudinal cartilage degeneration by using MR T1ρ/T2 imaging. The first 6-month changes of T1ρ/T2 values of the cartilage and anterior horn of medial meniscus significantly correlated with the 3-year cartilage degenerative change after ACL reconstruction. And also, T2 values of the posterior horn of medial meniscus prior to surgery significantly correlated with the cartilage degeneration of anterior medial tibia 3-year after the reconstruction. |
| 461 | 15:21
|
Quantitative Assessment of Disc Biochemical Composition and Vertebral Body Fat in Patients with Low Back Pain |
1Radiology, UCSF, San Francisco, CA, United States, 2Orthopedic Surgery, UCSF, San Francisco, CA, United States |
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We present a cross sectional study of 53 subjects with chronic lower back pain (n=39) and healthy controls (n=14). We have assessed disc biochemical composition (T1rho and T2 mapping) and vertebral bone marrow fat (6-point chemical-shift based imaging) as well as Pfirrmann grading. We have found significant associations between mean and standard-deviation of T1rho and T2 with vertebral bone marrow fat content in the adjacent vertebral body. We have also found strong associations of T1rho and T2 with clinical Pfirrmann grading. |
| 462 | 15:33
|
New Diffusion Tensor and Dixon Imaging Results in Human Skeletal Muscle from the GESTALT Longitudinal Study of Aging |
1Norwich Medical School, University of East Anglia, Norwich, United Kingdom, 2National Institute on Aging, National Institutes of Health, Baltimore, MD, United States, 3Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States |
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This work investigates how aging influences skeletal muscle diffusion tensor imaging (DTI) measures in a healthy cohort with a broad age range. Sixty participants, from 23-87 years old, were recruited and tract-based DTI indices were calculated in their thigh quadriceps muscles. Through piecewise regression, we identified trends in DTI indices and Dixon fat measures with respect to age, including a previously undocumented decline in fractional anisotropy (FA) in older age, particularly in men (r=-0.46, p=0.06). Our results also show statistically significant differences in FA between quadriceps muscles (p<0.001) that may reflect differences in composition and patterns of use. |
15:45
|
Adjournment & Meet the Teachers |
| N03 | Tuesday 13:45 - 15:45 | Moderators: Stamatios Sotiropoulos & David Atkinson |
| 463
|
13:45
|
Diffusion Acceleration with Gaussian process Estimated Reconstruction (DAGER) |
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen, Germany |
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Diffusion acceleration is a challenging task, particularly when using simultaneous multi-slice (SMS) imaging with in-plane acceleration. In this work, we develop a method termed DAGER: Diffusion Acceleration with Gaussian process Estimated Reconstruction, to improve SMS with in-plane acceleration, achieving a total acceleration factor of 12 (MB=4, R=3). In addition, DAGER reconstruction doesn't cause major degradation of angular resolution, indicating the Gaussian process model used in DAGER can accurately estimating the degree of local smoothness in q-space. |
| 464
|
13:57
|
Multi-shell SHARD reconstruction from scattered slice diffusion MRI data in the neonatal brain |
1Centre for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom |
||
Diffusion MRI (dMRI) offers a unique probe into neural connectivity in the developing brain. However, analysis of neonatal brain imaging data is complicated by inevitable subject motion. Here, we develop a method for reconstructing multi-shell HARDI data from scattered slices, jointly estimating an uncorrupted data representation and per-excitation (slice or multiband package) motion parameters. The reconstruction relies on orthogonal decomposition of multi-shell dMRI data using a bespoke spherical harmonics and radial decomposition (SHARD), together with outlier rejection, distortion, and slice profile correction. We evaluate the method on publicly-released datasets for 40 neonatal subjects from the developing Human Connectome Project. |
| 465
|
14:09
|
Joint Virtual Coil Reconstruction with Background Phase Matching for Highly Accelerated Diffusion Echo-Planar Imaging |
1Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, 2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 3Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 4Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States |
||
We proposed a joint-virtual-coil (VC) acquisition/reconstruction method to improve accelerated single-shot EPI (SS-EPI) in diffusion imaging (DI). A background phase correction scheme for matching the phase of reference training data with accelerated diffusion-weighted data was developed for robust reconstruction. Additional Gy prewinding-blips were added to the EPIs, to create complementary shifted-ky sampling strategy across TRs, which help better utilizes smooth-phase and joint-information priors in the joint-virtual-coil (jVC) reconstruction. The proposed method was demonstrated in highly-accelerated DI with SS-EPI and extended to generalized slice dithered enhanced resolution (gSlider) acquisition to achieve efficient high-resolution DI. |
| 466
|
14:21
|
Magnitude versus complex-valued images for spinal cord diffusion MRI: which one is best? |
1Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 2Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 3Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, 4Philips UK, Guildford, Surrey, United Kingdom, 5NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montréal, Montréal, QC, Canada, 6Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montréal, QC, Canada, 7Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 8Dementia Research Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 9Brain MRI 3T Research Centre, C. Mondino National Neurological Institute, Pavia, Italy, 10Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy |
||
Advanced diffusion imaging of the spinal cord is hampered by low signal-to-noise ratio, leading to strong Rician bias in magnitude images. Here, we investigate how to mitigate such bias studying complex-valued 3T diffusion scans of the cervical cord. We test two approaches, based on decorrelated phase (DP) and total variation (TV) filtering, corroborating results with simulations. The DP and TV methods, proposed for the brain, can be applied successfully also in the cord. Moreover, they appear useful pre-processing tools for image denoising, as state-of-the-art noise removal based on Marčenko-Pastur principal component analysis (MP-PCA) performs better on complex-valued as opposed to magnitude data. |
| 467 | 14:33
|
Robust estimation of diffusion MRI metrics based on slicewise outlier detection (SOLID) |
1Medical Physics, Radiology, Helsinki University Hospital, Helsinki, Finland, 2Department of Physics, University of Helsinki, Helsinki, Finland, 3Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, 4Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom |
||
The accurate characterization of diffusion process with MRI is compromised by various artefacts including intensity related errors. If not appropriately accounted for, model estimates can become significantly biased resulting in erroneous metrics. Slicewise intensity errors, in particular, are often handled by excluding the entire image or slice information, or by voxelwise robust estimators that experience difficulties in partial volume regions. In this work, we describe a fast and accurate algorithm to detect slicewise outliers and a framework to incorporate this information as data uncertainty in model estimation algorithms. |
| 468 | 14:45
|
Influence of the lipids on the quantification of IVIM parameters in the vertebral bone marrow. |
1LTSI, INSERM UMR 1099, Rennes, France, 2Centre Eugène Marquis, CRLCC, Rennes, France, 3Department of Imaging, Rennes University Hospital, Rennes, France |
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The aim of this study was to assess the effect of the lipids on the quantification of IVIM parameters in the vertebral bone marrow. Diffusion sequences were acquired with and without fat suppression on healthy volunteers. The results of our study show that fat is a confounding factor for the quantification of the diffusion coefficient and perfusion fraction; whereas it has no significant effect on the quantification of the pseudo-diffusion coefficient. |
| 469
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14:57
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Longitudinal multi-component HARDI atlas of neonatal white matter |
1Centre for the Developing Brain, School of Bioengineering and Imaging Sciences, King's College London, London, United Kingdom, 2Department of Biomedical Engineering, School of Bioengineering and Imaging Sciences, King's College London, London, United Kingdom |
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We describe a method for creating a longitudinal atlas of developing white matter (WM) of neonates using the multi-shell multi-tissue constrained spherical deconvolution technique and multi-contrast registration on high-quality high angular resolution diffusion imaging (HARDI) data. We present an atlas that consists of one isotropic and two orientationally-resolved components. The atlas reveals |
| 470 | 15:09
|
Probing microstructural heterogeneity and mild traumatic brain injury-induced gray matter alterations in the rat brain using diffusion kurtosis imaging |
1Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2University of Eastern Finland, Kuopio, Finland |
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In heterogeneous brain tissue microenvironments, the probability distribution of spin displacements deviates from Gaussianity. Examining the non-Gaussian behavior of the diffusion-encoded signal with diffusion kurtosis imaging (DKI) could potentially allow probing cellular heterogeneity and injury-induced changes that are not discernible in the limited (q,t)-regime that pulsed-gradient DTI with conventional b-values explores. Here, we investigated the sensitivity of DKI to intrinsic cellular heterogeneity and mild traumatic brain injury (mTBI)-induced gray matter (GM) alterations in the rat brain. The results demonstrate distinct contrasts in mean kurtosis maps reflecting microstructural heterogeneity in GM regions, and detection of region-specific alterations in the cortex and thalamus. |
| 471 | 15:21
|
Cross-vendor and Cross-protocol harmonisation of diffusion MRI data: a comparative study |
1CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 2Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 3Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 4Harvard Medical School, Boston, MA, United States, 5Image Sciences Institute, Department of Radiology, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands, 6Mint Labs Inc, Barcelona, Spain, 7Department of Radiology, University of Pennsylvania and the Children's Hospital of Philadelphia, Philadelphia, PA, United States, 8Institute of Imaging & Computer Vision, RWTH Aachen University, Aachen, Germany, 9Machine Intelligence and Perception group, Microsoft Research Cambridge, Cambridge, United Kingdom, 10New York University, New York, NY, United States |
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We present a comparison of five different methods that estimate mappings between scanners for diffusion MRI data harmonisation. The methods are evaluated on a dedicated dataset of the same subjects acquired on three distinct scanners with ‘standard’ and ‘state-of-the-art’ protocols, with the latter having higher spatial and angular resolution. Our results show that cross-vendor harmonisation and spatial/angular resolution enhancement of single-shell diffusion data sets can be performed reliably, although some challenges remain. The dataset is available upon request and can serve as a useful testbed for future method development in cross-site/cross-hardware and cross-vendor diffusion MRI harmonisation. |
| 472 | 15:33
|
Segmentation of the brain using direction averaged signal in DWI images |
1Psychological and Brain Sciences, Indiana University, Bloomington, IN, United States |
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A novel segmentation method using the direction-averaged DWI signal is proposed. Two images can be obtained from the fitting of the direction-averaged DWI signal: one with superior contrast between the gray matter and white matter; one with prominent CSF contrast. A pseudo T1 weighted image can be constructed and standard segmentation tools can be applied. The method was tested on the HCP subjects in SPM12 and FSL, and showed good agreement with segmentation using the T1 weighted image with the same resolution. |
| S02 | Tuesday 13:45 - 15:45 | Moderators: Freddy Odille & Giulia Ginami |
| 473 | 13:45
|
Assessment of respiratory motion-resolved and nonrigid motion-corrected 3D Cartesian coronary MRA |
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom |
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Slow acquisitions and susceptibility to respiratory motion artifacts are major challenges in free-breathing 3D whole-heart coronary MR angiography (CMRA). Recently, a respiratory-resolved approach has been proposed to improve scan efficiency and reduce motion artifacts using non-Cartesian acquisitions. However, irregular respirations compromise its suitability for Cartesian imaging. Here, sparsity in a motion-corrected domain is exploited to generate high-quality respiratory-resolved Cartesian images, used to estimate nonrigid motion fields. These are incorporated into a motion-corrected generalized matrix reconstruction, to further improve coronary vessel sharpness. Thus, this approach provides high-quality respiratory-resolved Cartesian CMRA images and a motion-corrected CMRA image at a given respiratory phase. |
| 474
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13:57
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Nonrigid Motion Correction using 3D iNAVs with Generalized Motion Compensated Reconstruction and Autofocusing |
1Electrical Engineering, Stanford University, Stanford, CA, United States |
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We present a novel framework to combine two well-known methods for motion correction: generalized motion compensated reconstruction (GMCR) and autofocusing. In this hybrid technique, 3D image-based navigators (3D iNAVs) are utilized for motion tracking. The beat-to-beat and voxel-by-voxel motion information within the 3D iNAVs are directly inputted into GMCR to mitigate motion artifacts. To reduce computation time, an autofocusing step is incorporated. The overall correction scheme is evaluated in free-breathing coronary magnetic resonance angiography and renal magnetic resonance angiography exams. In all six in vivo studies, images reconstructed with the proposed strategy outperform those generated with beat-to-beat 3D translational correction. |
| 475 | 14:09
|
Effects of reconstruction with deformable motion correction on abdominal DCE-MRI images |
1Radiation Oncology, University of Michigan, Ann Arbor, MI, United States, 2Radiology, University of Michigan, Ann Arbor, MI, United States, 3Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States |
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Image reconstruction with deformable motion correction for dynamic contrast-enhanced (DCE) MRI can counteract artifacts in dynamic images and estimated perfusion maps. In this study, we present the results of applying a reconstruction method with deformable motion correction to 54 DCE-MRI examinations of 31 patients. Deformable motion correction is found to compensate for up to 15 mm of residual motion after rigid-body motion correction. Motion-correction also reduces liver-wide bias caused by motion-distorted input functions and removes localized artifacts at liver edges. Finally, for several cases, motion-correction makes lesion edges sharper in reconstructed images. |
| 476 | 14:21
|
3D non-rigid motion-corrected dynamic contrast enhanced MRI of the liver with high isotropic resolution |
1Department of Radiology, Charité, Berlin, Germany, 2Division of Imaging Sciences and Biomedical Engineering, King’s College London, London, United Kingdom, 3Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany |
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Dynamic Contrast Enhanced (DCE) MRI of the liver is an important diagnostic tool. The main challenge is complex respiratory motion of the abdomen. Here we present a motion correction approach for DCE-MRI. Golden Radial Phase Encoding data was acquired continuously in a patient after contrast injection during free-breathing. In a first step, non-rigid respiratory motion was estimated from the data. The motion information was then used to reconstruct 3D motion corrected dynamic images with a temporal resolution of 13s and an isotropic spatial resolution of 1.5mm3. The proposed technique strongly reduced motion artefacts and ensured high image quality. |
| 477
|
14:33
|
Cardiac and respiratory motion-corrected whole-heart PET-MR imaging for simultaneous assessment of coronary anatomy, cardiac function and myocardial integrity |
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare, Frimley, United Kingdom, 3Nuclear Medicine, TU Munich, Munich, Germany |
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Image degradation due to cardiac and respiratory motion remains a challenge for cardiac PET-MR imaging. Here we propose a simultaneous dual-phase PET and Coronary MR angiography (CMRA) acquisition and reconstruction framework that allows for the visualisation of coronary anatomy, estimation of ventricular function and motion-corrected myocardial PET in a single efficient examination. A validation study in healthy subjects shows that left ventricular ejection fraction can be estimated from dual-phase CMRA images at 3T. Results from patients with cardiovascular disease show improvements in respiratory motion corrected dual-phase CMRA and in PET image quality when applying both cardiac and respiratory motion correction. |
| 478 | 14:45
|
Joint PET-MR image registration for cardiac and respiratory motion correction of simultaneous cardiac PET-MR |
1Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, 2Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 3MR Research Collaborations, Siemens Healthcare, Frimley, United Kingdom, 4MR R&D Collaborations, Siemens Medical Solutions, New York, NY, United States, 5Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, United Kingdom |
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Cardiac Positron Emission Tomography (PET) can provide diagnostic information about myocardial perfusion and metabolism with excellent sensitivity. The main challenge is physiological motion of the heart due to breathing and heartbeat. Here we present a joint PET-MR image registration approach which provides non-rigid cardiac and respiratory motion information utilising image data from a simultaneous PET-MR scan of less than 4min. In addition, attenuation correction information is also derived from the MR scan. The motion information is utilised in a motion-corrected PET image reconstruction which improves PET image quality, enhances visualisation of small features and increases measured uptake values by 22±7%. |
| 479 | 14:57
|
Improved subsampling trajectory for reliable assessment of cardiac and respiratory motion in 5D MRI for body motion correction |
1Section on Experimental Radiology, University Hospital of Tuebingen, Tuebingen, Germany, 2Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany, 3Department of Radiology, University Hospital of Tuebingen, Tuebingen, Germany |
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Respiratory and cardiac motion may cause artifacts in body trunk imaging if patients cannot hold their breath or triggered acquisitions are not practical. Retrospective correction strategies cope with motion by fast sequences under free-movement conditions. In the acquisition, a random subsampling with global variable-density scaling is usually applied. Improved sampling efficiency in terms of acquired SNR per sample can be achieved if the underlying energy distribution is considered. An image upscaling via dictionary learning from the localizer with extraction of the energy distribution and local shaping of the hybrid Cartesian subsampling improves the overall image quality and SNR by 45%. |
| 480 | 15:09
|
Estimation of a signal-appropriate reference volume to improve registration of high b-value diffusion volumes in the human placenta |
1Medical Biophysics, Western University, London, ON, Canada, 2Dept of Obstetrics and Gynaecology, Western University, Ontario, ON, Canada, 3Division of Maternal, Fetal, and Newborn Health, Children's Health Research Institute, London, ON, Canada |
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A technique is presented to aid in better motion correction of high b-value diffusion images of the human placenta in utero for the purposes of quantification using intra-voxel incoherent motion (IVIM). A registration reference volume is calculated with signal intensities and tissue features with similarity to volumes with high diffusion weighting, and produce more successful registrations than when using the b=0 volume as a reference. |
| 481 | 15:21
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Off k-space center and spin-history artifacts Self-Navigator Intelligent Filter (SNIF) for quasi-random 3D-radial acquisitions |
1Laboratoire d'Imagerie par Résonance Magnétique Médicale et Multi-Modalités (IR4M), Université Paris-Sud, Orsay, France, 2Université Paris-Saclay, Orsay, France, 3CNRS, Orsay, France, 4Applications & Workflow, GE Healthcare, Orsay, France, 5Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States |
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For 3D radial acquisitions featuring a quasi-random order of spoke orientations in k-space, implementable in UTE pulse sequences, respiratory and cardiac self-navigators are usually extracted from the assumed k-space center thanks to standard bandpass filters to perform self-gating. To remove more efficiently the background noise, SNIF, Self-Navigator Intelligent Filter, takes into account the underlying physics of the MR acquisition to filter out of the DC signal both off k-space center and spin-history effects. SNIF systematically enhances both respiratory and cardiac self-navigators. It even sometimes reveals their spectral first harmonics, which remained otherwise buried into the background noise. |
| 482 | 15:33
|
CAPTURE: Consistently-Acquired Projections for Tuned and Robust Estimation - A Self-Navigated Respiratory Motion Correction Approach |
1Washington University in St. Louis, St. Louis, MO, United States |
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In this study, we present a fully-automated and robust self-navigated approach to obtain 4D motion-resolved images during free breathing. A 1D navigator was acquired consistently in order to reduce the signal contamination due to system imperfections. The resulting projections were then 'tuned' using complex phase rotation for adapting to scan-to-scan variations, followed by the detection of the respiratory curve. CAPTURE successfully detected respiratory motion in all subjects. A blind radiological review by two radiologists shows the significant quality improvement in motion-corrected images. |
| S03 | Tuesday 13:45 - 15:45 | Moderators: Claudia Calcagno & Kevin DeMarco |
| 483 | 13:45
|
Relationship between MR characteristics of peripheral artery lesions and difficulty of peripheral endovascular procedures |
1Schulich Heart Program and the Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 2Division of Vascular Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada, 3Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada |
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The most common mode of failure for percutaneous vascular interventions (PVI) is the inability to cross hard lesions with a guidewire. This study uses magnetic resonance (MR) lesion characterization to predict the difficulty of PVI. Steady state free precession (SSFP) MR angiography and ultrashort echo time imaging were used to categorize lesions as “hard” (e.g. calcium, collagen), or “soft” (thrombus, lipids). 17 patients were imaged prior to PVI. MRI-defined hard lesions required significantly longer time to cross (14.81 min vs 1.61 min) and required stenting more often. |
| 484 | 13:57
|
Antibiotic treatment affects vascular elastin remodeling both focally and distally to the site of aortic injury in a murine model |
1School of Biomedical Engineering Imaging Sciences, King's College London, London, United Kingdom, 2Radiology department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile |
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Atherosclerosis is a systemic, inflammatory disease of the large and medium-sized arteries. Although vascular interventions aim at treating focal stenosis, they may trigger systemic responses that accelerate lesions elsewhere. Elastin remodeling plays a crucial role in vessel wall thickening with monocytes and vascular smooth muscle cells (VSMC) being the primary sources of elastin synthesis. In this study, we used an elastin-binding MR contrast agent to assess whether (1) vascular injury in the abdominal aorta accelerates atherosclerosis in the brachiocephalic artery located distally to the site of injury (2), whether antibiotic treatment alters vascular elastin remodeling and (3) whether antibiotic treatment alters VSMC migration and proliferation and monocyte recruitment and polarization. |
| 485 | 14:09
|
In Vivo Quantification of Aortic Stiffness in Abdominal Aortic Aneurysm Patients using MR Elastography: A Longitudinal Study |
1Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, United States, 2Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States, 3Center for Biostatistics, The Ohio State University, Columbus, OH, United States |
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Abdominal aortic aneurysm (AAA) rupture causes death in 90% of AAA patients. Clinically, the rupture potential is evaluated using AAA diameter. Aortic stiffness can potentially provide more accurate rupture risk assessment. Therefore, the aim of this study is to use non-invasive MR elastography (MRE) to estimate aortic stiffness in AAA patients, and study the relationship between stiffness and AAA diameter. Results showed that aortic stiffness varied during the serial follow-up, demonstrating (1) no correlation between AAA stiffness and diameter, and (2) AAA diameter may not be an accurate indicator for rupture potential. |
| 486 | 14:21
|
Increases in the Prevalence of Subclinical Cerebrovascular Atherosclerosis with Age: A 3.0 T Magnetic Resonance Imaging Study of Community-based Adults |
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China, 2Department of Neurology, Beijing Tiantan Hospital, Beijing, China, 3Center for Brain Disorders Research, Capital Medical University and Beijing Institute for Brain Disorders, Beijing, China, 4Department of Radiology, University of Washington, Seattle, WA, United States |
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It is well established that atherosclerotic diseases occurring in intracranial and extracranial carotid arteries are associated with ischemic cerebrovascular events. It is important to find a surrogate risk factor for subclinical cerebrovascular atherosclerosis in asymptomatic subjects for stroke prevention. This study sought to investigate the association between age and subclinical cerebrovascular atherosclerosis in community-based adults using MR vessel wall imaging. We found that the prevalence of cerebrovascular atherosclerotic plaques increased with age. The association between age and cerebrovascular atherosclerosis suggests that age was an independent indicator for subclinical cerebrovascular atherosclerosis. |
| 487
|
14:33
|
Vascular risk factors and intracranial atherosclerosis at 7T vessel wall MRI in Caucasian ischemic stroke and TIA patients |
1Radiology, UMC Utrecht, Utrecht, Netherlands, 2Neurology, UMC Utrecht, Utrecht, Netherlands, 3Epidemiology, UMC Utrecht, Utrecht, Netherlands |
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There is a lack of knowledge on the association between cardiovascular risk factors and intracranial atherosclerotic lesion burden in the Caucasian population. In this study 105 Caucasian stroke and TIA patients underwent 7T intracranial vessel wall imaging within 3 months after symptom onset. Poisson regression analysis showed that older age, higher systolic blood pressure, diabetes mellitus and a higher SMART risk score (wherein multiple cardiovascular risk factors are combined) were associated with a higher number of vessel wall lesions. Controversially, dyslipidemia and cigarette smoking were not associated with the severity of intracranial vessel wall lesions. |
| 488 | 14:45
|
Preliminary study of PET/MR 18F-NaF imaging combined with CATCH sequence of high-risk plaque |
1Department of Nuclear Medicine, Chinese PLA General Hospital, Beijing, China, 2Department of Cardiology, Chinese PLA General Hospital, Beijing, China, 3Cedars Sinai Medical Center, Los Angeles, CA, United States, 4Siemens Shenzhen Magnetic Resonance Ltd. China, Beijing, China |
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This study aimed to investigate the value of PET/MR 18F-NaF combined with CATCH technology in the diagnosis of high-risk plaque preliminarily. We compared if it had the statistical difference of PMR and TBRmax between the culprit vascular plaque and the control,and evaluated if it had correlation between PMR and TBRmax. There were higher PMR and TBRmax in culprit plaque. PMR and TBRmax had a weak correlation. PET/MR 18F-NaF combined with the CATCH technique can noninvasively determine the location of high-risk plaque in coronary artery, and is valuable for the diagnosis of high-risk plaque. |
| 489 | 14:57
|
Gender-Related Difference in Atherosclerosis: Magnetic Resonance Coronary Artery Wall Thickness is a Predictor of Coronary Plaque Burden in Asymptomatic Young Women |
1Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, United States, 2Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, United States, 3Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, United States, 4Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, Bethesda, MD, United States |
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This study evaluates the potential association of coronary plaque burden with traditional atherosclerosis risk factors and coronary wall thickness (VWT) measured with time-resolved phase-sensitive dual-inversion black-blood TRAPD-MRI. The study demonstrates that there is substantial coronary plaque burden in asymptomatic subjects at low and intermediate Framingham score. In addition, there was evidence of a gender-dimorphic association between the predictors and plaque burden. In women, coronary wall thickness was the strongest and common significant predictor for all plaque burden scores and the presence of calcification. Meanwhile in men, age was the strongest and common predictor of all plaque burden scores and the presence of calcification. This suggests that atherogenesis in women may differ from men and that VWT could supplement traditional risk scores for CAD risk stratification in women. This is in line with the previous studies that demonstrated the impaired utility of these CAD risk score models for women compared to men. |
| 490 | 15:09
|
Association between Vulnerability of Carotid Artery Atherosclerotic Plaques and White Matter Lesions in Asymptomatic Elderly Population: A MR Vessel Wall Imaging Study |
1Department of Radiology, Taizhou People's Hospital, Taizhou, China, 2Department of Radiology, Yangzhou First People’s Hospital, Yangzhou, China, 3Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, 4Department of Radiology, University of Washington, Seattle, WA, United States, 5Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China |
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This study investigated the relationship between morphological and compositional characteristics of carotid artery atherosclerotic plaques and WML in asymptomatic elderly population using 3D multicontrast MR vessel wall imaging. We found that carotid artery plaque compositional characteristics, especially calcification, intraplaque hemorrhage, and high risk plaque, were significantly associated with the severity of WML, suggesting that vulnerable atherosclerotic plaque in carotid artery might be an independent indicator for cerebral ischemic lesions in asymptomatic elderly adults. |
| 491 | 15:21
|
Intraplaque Hemorrhage and Calcification Detection with Quantitative Susceptibility Mapping |
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2The MRI Institute for Biomedical Research, Detroit, MI, United States, 3Center for Functional and Metabolic Mapping, Robarts' research institute, Western University, London, ON, Canada, 4Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 5Xuanwu Hospital, Capital Medical University, Beijing, China |
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In carotid atherosclerosis, the vulnerable feature that has drawn the most attention is intraplaque hemorrhage (IPH). Clinically, MPRAGE has been used to detect IPH. However, IPH has several drawbacks. The susceptibility difference between arterial blood, vessel wall and different types of plaque makes QSM a potential tool for carotid plaque imaging. The purpose of this work was to develop an optimized protocol for both intraplaque hemorrhage and calcification imaging using Quantitative Susceptibility Mapping (QSM) and demonstrate initial clinical validation of QSM as a tool for characterizing components of carotid plaque. |
| 492 | 15:33
|
Identification of high-risk plaque features in intracranial atherosclerosis: initial experience using high-resolution MRI with a quantitative radiomics approach |
1Radiology, Changhai Hospital, Shanghai, China, 2Radiology, University of California, San Francisco, CA, United States |
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This study aims to evaluate a radiomic approach including texture analysis based on HR-MRI to differentiate acute symptomatic plaque from asymptomatic plaque. 94 patients with basilar artery stenosis underwent HR-MRI. The stenosis value, plaque area/burden, lumen area, intraplaque hemorrhage (IPH), contrast enhancement ratio and 94 quantitative radiomic features were extracted. Multivariate logistic analysis and a random forest model were performed. Results: IPH and enhancement ratio were independently associated with acute symptoms. Radiomic features in T1 and CE-T1 images were associated with acute symptoms. The combined T1 and CE-T1 radiomic approach had a significantly higher AUC of 0.940. Conclusion: Radiomic analysis accurately distinguished between acutely symptomatic plaques and asymptomatic plaques. |
| S04 | Tuesday 13:45 - 15:45 | Moderators: Christopher Quarles & Peiying Liu |
| 493
|
13:45
|
Flow Compensation in Dynamic Susceptibility Contrast MRI for an Increase in Arterial Input Function Precision |
1Centre d’imagerie moléculaire de Sherbrooke, Département de médecine nucléaire, Université de Sherbrooke, Sherbrooke, QC, Canada, 2MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, 3Service de neurochirurgie, Département de chirurgie, Université de Sherbrooke, Sherbrooke, QC, Canada |
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Arterial input functions (AIF) measured inside major arteries in perfusion MRI are derived from the contrast agent induced changes in the blood signal. Such signal measurements of flowing blood are prone to (in)flow induced effects. Here, the effects of pulsatile blood flow are studied for AIF measurement in dynamic susceptibility contrast (DSC) with dual-echo single-shot EPI. First moment flow compensation is shown to partially recover the noise attributed to flow effects. The resulting signal-to-noise ratio is increased by a factor of 14 (2) in the middle (internal) carotid artery providing a more precise AIF for cerebral blood flow calculation. |
| 494
|
13:57
|
Comparison of Cerebral Blood Volume Estimates using Quantitative Susceptibility Mapping, and R2* relaxometry |
1Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Department of Radiology, Basel University Hospital, Basel, Switzerland |
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Intracranial vascularity is modified in a wide array of diseases, including various forms of dementia, cancer, and stroke. When assessment of the vascular architecture is needed, one potential approach is steady state imaging with ferumoxytol to estimate cerebral blood volume (CBV). Building upon recent work, in this study we investigate the correlation between QSM and R2* based CBV estimates. Results from 19 healthy volunteers show that the QSM based CBV estimates demonstrated a high degree of correlation in gray and white matter, but larger variance than R2* based measures. |
| 495
|
14:09
|
The effects of diffusion on the tissue orientation dependent gradient echo dynamic susceptibility contrast signal |
1UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 2Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 3Pediatrics, University of British Columbia, Vancouver, BC, Canada, 4Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 5Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada |
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Gradient echo dynamic susceptibility contrast (DSC) imaging of cerebral white matter tissue perfusion exhibits a strong dependency on the angle between white matter fibres and the main magnetic field. Here, we investigate the extent to which the diffusion of spins within the locally magnetically inhomogenous environment affects the orientation dependency of the DSC signal using a numerical model of the transverse magnetization within a voxel containing both isotropic and anisotropic vasculature. We found that diffusion increases the measured change in $$$R_2^*$$$ by up to an average of 3.2% for typical diffusion values, independent of fibre orientation, and further improves the fit between the simulated and measured $$$R_2^*$$$ values. |
| 496 | 14:21
|
Accelerated dynamic quantitative perfusion imaging using an optimized simultaneous multi-slice (SMS) spin and gradient echo (SAGE) sequence with joint-virtual coil (JVC) reconstruction |
1MGH Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States, 2Department of Biomedical Engineering, Zhejiang University, Hangzhou, China |
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A 5-echo spin and gradient echo (SAGE) sequence was implemented with SMS to provide whole brain coverage at a high spatio-temporal resolution during DSC imaging. Complementary k-space sampling between echoes and joint-virtual coil (JVC) reconstruction were used to achieve high quality reconstruction at 9x acceleration, which enabled 1.9x1.9x5 mm whole-brain imaging at a TR of 1.6s. The multi-echo images from this sequence were fit to achieve quantitative R2 and R2* maps for each TR. This has been shown to limit T1 leakage effects and provide more accurate and detailed perfusion measures with the potential to better assess tumor diagnostics and progression. |
| 497 | 14:33
|
Quantitative assessment of exercise-stimulated muscle perfusion: a comparison between DCE and DSC imaging |
1Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, 2Division of Geriatrics, University of Utah, Salt Lake City, UT, United States, 3Epidemiology, University of Utah, Salt Lake City, UT, United States, 4Cardiovascular Medicine, University of Utah, Salt Lake City, UT, United States, 5Vascular Surgery, University of Utah, Salt Lake City, UT, United States |
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For one group of healthy subjects, we measured exercise-stimulated perfusion in calf muscles using both DCE and DSC MRI, and found that the muscle perfusion estimates by the two methods were comparable, but the vascular-fraction estimates were not. Without confounding contribution from extravascular signals, DSC data has the potential of characterizing tissue vasculature more precisely. Acquisition of both DCE and DSC data in one exam can be achieved with either two injections of low contrast dose or acquisition techniques of interleaved T1 and T2* imaging. |
| 498 | 14:45
|
Evaluation of UTE for improved contrast enhanced DCE MRI at 7T |
1Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States |
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We investigated the feasibility of using an ultrashort echo time (UTE) technique for DCE MRI imaging of prostate cancer patients at 7T to minimize the impact of the increased R2* relaxivity on signal enhancement curves and pharmacokinetic parameter assessment. The Gd concentration-time curves and pharmacokinetic parameter maps were compared to clinical DCE MRI at 3T. The proposed method achieved DCE MRI at 7T with a signal time course comparable to 3T DCE MRI but with increased SNR for improved spatial resolution and no R2* effects, which are exacerbated with increasing field. |
| 499
|
14:57
|
A Multislice TRICKS-Based DCE-MRI Method for Measurement of Murine Kidney Function |
1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States, 2Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States |
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A multislice method based on time-resolved imaging of contrast kinetics was developed for measurement of murine kidney size and function. A total of eight slices covering both kidneys were imaged with a temporal resolution of 1.23 sec/scan. The estimated kidney volume showed a good agreement with a three-dimensional volume scan. By fitting contrast kinetics using a modified bi-compartment model, renal perfusion and normalized glomerular filtration rate (GFR) were quantified, and subsequently used to calculate renal blood flow and GFR. In conclusion, this method allows simultaneous and reliable measurement of mouse kidney volume, perfusion, blood flow, and GFR. |
| 500
|
15:09
|
Improved reliability for mapping water exchange across blood-brain barrier by diffusion prepared three-dimensional pseudo-continuous arterial spin labeling |
1Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States |
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A 3D diffusion-prepared gradient and spin echo (GRASE) pseudo-continuous ASL (pCASL) sequence was proposed to improve the reliability for mapping water exchange across the BBB non-invasively. The motion sensitive non-CPMG component signal was eliminated by gradients to spread the diffusion weighted signal across 4π before GRASE readout. Based on test-retest scans (~2 weeks apart) in aged subjects (67±8yrs), excellent reproducibility (ICC=0.87) was achieved for water exchange rate (Kw) measured by the proposed 3D sequence. Whole brain Kw was averaged to be 107.7±19.0 min-1 and 113.0±17.8 min-1 for the proposed 3D and 2D DW-pCASL method, respectively, well matching the literature results. |
| 501 | 15:21
|
Demonstrating a novel non-contrast MR perfusion technique: EVM-EPI MR perfusion |
1Neuroradiology, Massachusetts General Hospital, Boston, MA, United States, 2Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States, 3Neurology, University of Pittsburgh, Pittsburgh, PA, United States, 4Radiology, Massachusetts General Hospital, Boston, MA, United States |
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EVM-EPI MR perfusion is a novel, non-contrast MR perfusion technique, which amplifies latent imperceptible contrast variation in perfused tissue of a T2*-weighted cine acquisition via Fourier methods at frequencies of cardiac perfusion. |
| 502
|
15:33
|
Assessment of white matter anisotropy effects in mq-BOLD based mapping of relative Oxygen Extraction Fraction |
1Department of Neuroradiology, Technical University of Munich, Munich, Germany, 2Department of Radiology & Biomedical Imaging, Yale University, New Haven, CT, United States, 3Philips Healthcare, Hamburg, Germany, 4Departement of Radiology, Technical University of Munich, Munich, Germany, 5School of Engineering & Applied Science, Yale University, New Haven, CT, United States, 6Clinic for Neurology, Technical University of Munich, Munich, Germany |
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Anisotropy effects were proven to strongly affect T2* and DSC-measurements, however influences on the relative Oxygen Extraction Fraction (rOEF) by multi-parametric quantitative BOLD (mq-BOLD) have not been investigated yet. Therefore, we present a methodolocigal study within healthy elderly. The major aim was to evaluate anisotropy effects on rOEF and all mq-BOLD related parameters at the same time. We found strong orientation dependencies of T2*, T2, R2' and rCBV on the main-nerve-fiber orientation towards B0 with variations up to 26.6%. However, our results show rather low angle dependency of rOEF with 13.6% as R2’ and rCBV effects show partially counteracting influences. |
| S05 | Tuesday 13:45 - 15:45 | Moderators: Andre Obenaus & Guangming Lu |
| 503
|
13:45
|
Multi-parametric MRI data fusion reveals acute and persistent brain changes in concussed female varsity rugby players |
1Medical Biophysics, Western University, London, ON, Canada, 2Centre for Functional and Metabolic Mapping, Robarts Research Institute, London, ON, Canada, 3Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands, 4Molecular Medicine, Robarts Research Institute, London, ON, Canada, 5Microbiology and Immunology, Western University, London, ON, Canada, 6Anatomy and Cell Biology, Western University, London, ON, Canada, 7Primary Care Sport Medicine, Fowler Kennedy Sport Medicine, London, ON, Canada, 8Physical Medicine and Rehabilitation, Western University, London, ON, Canada, 9Paediatrics Critical Care Medicine, London Health Sciences Centre, London, ON, Canada, 10Occupational Therapy, Western University, London, ON, Canada, 11Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, Netherlands, 12Centre for Functional MRI of the Brain (FMRIB), Oxford University, Oxford, United Kingdom |
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Multi-parametric 3T MRI data was acquired in female varsity rugby players during the in- and off-season and compared to concussed teammates acutely (24-72 hours) and longitudinally (3- and 6-months) after a mild traumatic brain injury (mTBI). Using linked independent component analysis, we found acute and prolonged resting state functional connectivity and diffusion white matter microstructure changes that persisted beyond symptomatic recovery and clearance to return to play. These fused components also significantly correlated with aspects of concussion history and were robust and consistent across model orders and within individual concussed athletes longitudinally. |
| 504 | 13:57
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Chronic Neurovascular Dysfunction in a Mouse Model of Repeated Mild Traumatic Brain Injury |
1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Sunnybrook Research Institute, Toronto, ON, Canada, 3Mouse Imaging Centre, Toronto, ON, Canada, 4Grenoble Institut des Neurosciences, Université Grenoble Alpes, Grenoble, France, 5Bruker Biospin MRI, Ettlingen, Germany, 6Inserm, U1216, Grenoble, France, 7Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada |
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In-situ assessments of brain function following repeated mild traumatic brain injury (rmTBI) have yet to be seen. Herein, we report the first functional imaging study in the chronic phase of a mouse model of rmTBI. Pseudo-continuous arterial spin labelling MRI revealed a reduction in basal cerebral blood flow and cerebral reactivity, while electrophysiological recordings of evoked responses were greatly reduced in injured brain. Finally, immunohistochemical analysis of vascular endothelium, astrogliosis, and neurons was performed to investigate cellular populations. |
| 505 | 14:09
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A Weighted Head Accelerator Mechanism (WHAM) for imaging brain tissue deformation during mild head rotation using a tagged MRI sequence |
1Imaging Research Center/Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, Cincinnati, OH, United States, 2Radiology, Nationwide Children's Hospital, Columbus, OH, United States, 3Division of Sports Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 4Department of Physics, University of Cincinnati, Cincinnati, OH, United States, 5Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States |
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A new research tool, the Weighted Head Accelerator Mechanism (WHAM), is described. The WHAM, used together with a custom MRI sequence, permits in depth investigations into brain biomechanics during mild head rotations and the evaluation of mild traumatic brain injury mitigating strategies by directly evaluating their effects on brain biomechanics in vivo. |
| 506 | 14:21
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Ribbon Tractography Reveals Reorientation of White Matter in the Corpus Callosum Following Severe Traumatic Brain Injury |
1Harvard Medical School - Massachusett General Hospital - Martinos Center for Biomedical Imaging, Boston, MA, United States, 2Department of Neurology, Massachusetts General Hospital, Boston, MA, United States, 3Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States, 4University of São Paulo, São Paulo, Brazil |
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Traditional streamline tractography does not capture the changes in fiber twisting resulting from traumatic brain injury. We used ribbon tractography to quantify the acute directional changes in white matter tracts in patients with traumatic brain injury. We identified significant changes in the corpus callosum of these patients both as compared to healthy controls and between the acute and follow-up scans of a subset of patients. These findings reveal alterations in the architecture of the corpus callosum within and beyond the area of injury and offer a potential marker for structural changes that are not detected by standard techniques. |
| 507 | 14:33
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The Evolution of White Matter Microstructural Changes after Mild Traumatic Brain Injury: A Longitudinal DTI and NODDI Study |
1Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Department of Radiology, University of Washington, Seattle, WA, United States, 3Brain and Spinal Cord Injury Center, San Francisco General Hospital and Trauma Center, San Francisco, CA, United States, 4Department of Neurological Surgery and Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, United States, 5Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States |
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Problem: Mild traumatic brain injury (mTBI) can result in long-term sequelae. Lack of sensitive biomarkers makes diagnosis challenging. Methods: Cross-sectional and longitudinal study of 40 mTBI patients at 2 weeks and 6 months after injury. Diffusion tensor imaging and multishell neurite orientation dispersion and density imaging (NODDI) parameters were assessed. Results: Cross-sectional analysis between patients at 2-weeks and controls revealed a decrease of fractional anisotropy and increase of mean diffusivity in the patient group together with elevated free water values. Longitudinally, after mTBI, a decline in neurite density was observed. Conclusions: NODDI measurements are sensitive imaging biomarkers for the subtle underlying white matter pathology after mTBI. |
| 508 | 14:45
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5-Year Arterial Spin Labeling MR Perfusion sequelae of concussive blast traumatic brain injury |
1University of Washington Medical Center, Seattle, WA, United States |
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Concussive blast traumatic brain injury (cbTBI) may benefit from evaluation with advanced MR imaging techniques. Here we report the results of a 5-year follow-up prospective, observational, longitudinal human cohort study evaluating cbTBI using arterial spin labeling, correlated with durable measures of long term outcome taken from an extensive battery of neurobehavioral, neuropsychological, and psychiatric evaluations. Specifically, service members who sustained combat-related cbTBI exhibited significant, regional hypoperfusion 5 years post-injury compared to combat-deployed controls, associated with measures of long term outcome. |
| 509 | 14:57
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Redundancy and resiliency of arousal mechanisms in traumatic coma patients |
1Department of Radiology, A.A. Martinos Center for Biomedical Imaging, MGH and Harvard Medical School, Boston, MA, United States, 2Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States, 3Department of Neurology, A. A. Martinos Center for Biomedical Imaging, MGH and Harvard Medical School, Boston, MA, United States |
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Traumatic brain injury to brainstem/thalamic/hypothalamic/basal-forebrain arousal nuclei is implicated in the pathogenesis of coma. However, due to difficulty in localizing these nuclei with conventional MRI, it is unknown which lesioned nuclei cause coma, and which are compatible with recovery of arousal/consciousness. We mapped our recently developed brainstem arousal-nuclei atlases and current thalamic/hypothalamic/basal-forebrain atlases to 3Tesla susceptibility-weighted-images in twelve acute traumatic-coma patients, who recovered full arousal/consciousness within six-months. We identified multiple combinations of injured brainstem/thalamic arousal-nuclei that cause acute coma, yet are compatible with a full recovery of arousal/consciousness. Thus, there is redundancy and resiliency of arousal mechanisms in traumatic coma. |
| 510
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15:09
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Assessing Mild Traumatic Brain Injury (TBI) Induced Optic Neuropathy in Novel Closed-head Injury Mouse Model Using Diffusion Basis Spectrum Imaging (DBSI) |
1Radiology, Washington University School of Medicine, St Louis, MO, United States, 2Neurology, Washington University School of Medicine, St Louis, MO, United States, 3Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, United States, 4Biomedical Engineering, Washington Univerisyt is St. Louis, St Louis, MO, United States |
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Traumatic brain injury (TBI) is a major cause of death and disability worldwide, and mild TBI (mTBI) is the most common type injury. TBI-induced optic neuropathy (ON) has recently raised attention due to subjective complaints of visual impairment. Currently, non-invasive and longitudinal direct assessment in TBI-induced ON is still limited. In the current study, we applied diffusion basis spectrum imaging (DBSI) to a novel surgery-free and closed-head impact model of TBI called modCHIMERA at 3 days post-injury to study TBI-induced ON with histological validation on our imaging metrics. |
| 511 | 15:21
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Association Between Concussion-induced Dizziness and Damage of Thalamo-cortical Connectivity after mild Traumatic Brain Injury |
1Research Center of Translational Imaging, College of Medicine, Taipei Medical University, Taipei, Taiwan, 2Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 3Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, 4Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 5Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan, 6Department of Medical Research, Taipei Medical University Hospital, Taipei, Taiwan |
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Dizziness is a frequent symptom of concussion, however neuroimaging evidence that supports clinical symptoms after mTBI was less explored. This study demonstrated the post-concussion damages of thalamo-cortical networks revealed by the axonal injuries of specific fiber tracts and the altered functional connectivity. The estimates of Dizziness Handicap Inventory significantly correlated to the functional connectivity of thalamic nuclei. |
| 512 | 15:33
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Metabolic concentrations in normal appearing brain tissue: 3 month after severe pediatric TBI. |
1Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russian Federation, 2Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation, 3Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russian Federation |
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In this study for the first time cerebral NAA, Asp and Glu concentrations of major inhibitory were simultaneously estimated in patients severe TBI . This work revealed significant reduction NAA and Asp concentrations in frontal lobe (on 65 and 61% respectively) in patients with severe TBI as compare to control group. At the same time, there was no significant change in Glu concentration. Our findings indicate that the main reason for the [NAA] reduction in the chronic severe TBI is caused by a decrease in [Asp]. Precursor of synthesis [NAA]. [Asp] reduction along with an unchanged Glu level may be caused by the dysfunction of one of the most important metabolic regulation systems - the malate-aspartate shuttle (MAS). |
| S06 | Tuesday 13:45 - 15:45 | Moderators: Reena Jha & Jeong Hee Yoon |
| 513
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13:45
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Noninvasive Staging of Liver Fibrosis using Magnetic Resonance, Ultrasound, and Transient Elastography: a Comparison with Liver Biopsy |
1Centre de recherche du centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada, 2Department of Gastroentology and Hepatology, Université de Montréal, Montreal, QC, Canada, 3Department of Medicine, Division of Gastroenterology, McGill University Health Centre (MUHC), Montreal, QC, Canada, 4Department of Pathology, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada, 5Department of Pathology and Cellular Biology, Université de Montréal, Montreal, QC, Canada, 6Department of Radiology, Radio-Oncology and Nuclear Medicine, Université de Montréal, Montreal, QC, Canada, 7MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada |
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Elastographic techniques measure liver stiffness as surrogate biomarker of liver fibrosis. We performed paired comparisons of MRE, pSWE, and TE for staging liver fibrosis. For classification of dichotomized fibrosis stages F0 vs. ≥ F1, ≤ F1 vs. ≥ F2, ≤ F2 vs. ≥ F3, and ≤ F3 vs. F4, the AUCs were respectively 0.92, 0.84, 0.89, 0.89 for MRE; 0.76, 0.83, 0.80, 0.75 for pSWE; and 0.75, 0.70, 0.77, 0.84 for TE. Overall, MRE provided a diagnostic accuracy similar or higher than ultrasound-based elastographic techniques. |
| 514 | 13:57
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Liver R2* as a Biomarker of Liver Iron Concentration: Interim Results from a Multi-Center, Multi-Vendor Reproducibility Study at 1.5T and 3T |
1Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 3Global MR Applications & Workflow, GE Healthcare, Menlo Park, CA, United States, 4Radiology, The Johns Hopkins University, Baltimore, MD, United States, 5Siemens Healthineers, Baltimore, MD, United States, 6Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 7Radiology, Technical University of Munich, Munich, Germany, 8Siemens Healthineers, Los Angeles, CA, United States, 9Medicine, University of Wisconsin-Madison, Madison, WI, United States, 10Radiology, Stanford University, Stanford, CA, United States, 11Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 12Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 13Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States |
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R2* is a promising biomarker of liver iron concentration (LIC), with application in the assessment of iron overload. Previous works have demonstrated the high correlation of liver R2* with biopsy-determined LIC. Although R2* measurements may be affected by multiple confounding factors, including the presence of fat and noise bias, confounder-corrected R2* mapping has been shown to be highly insensitive to the presence of these confounding factors. However, the multi-center reproducibility of confounder-corrected R2* for liver iron quantification remains unknown. This abstract demonstrates excellent reproducibility of R2* for liver iron quantification in a multi-center, multi-vendor study at both 1.5T and 3T. |
| 515 | 14:09
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Estimating Liver Water and Fat T1 and T2, and PDFF using Flip Angle Corrected Multi-TR, Multi-TE 1H MRS |
1Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, CA, United States, 2NAFLD Research Center, Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, CA, United States |
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Multi-TR, multi-TE (MTRTE) 1H MRS estimates T1 and T2 of fat and water and liver proton density fat fraction (PDFF) in a single breath-hold by assuming a perfect 90° pulse, which is not guaranteed in vivo and may introduce bias. We introduce a flip angle corrected multi-TR, multi-TE (FAC MTRTE) 1H MRS sequence based on a non-steady state approach and compare the T1, T2, and PDFF given by MTRTE and FAC MTRTE MRS. T1 estimates given by MTRTE MRS and FAC MTRTE MRS were significantly different, due to the MTRTE sequence not being acquired with a perfect 90° flip. |
| 516 | 14:21
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Rapid multi-slice abdominal T1 mapping with high spatial and temporal resolution using an inversion recovery radial steady-state free precession (IR-radSSFP) technique |
1Electrical and Computer Engineering, The University of Arizona, Tucson, AZ, United States, 2Department of Medical Imaging, The University of Arizona, Tucson, AZ, United States, 3Biomedical Engineering, The University of Arizona, Tucson, AZ, United States, 4Siemens Healthcare, Tucson, AZ, United States |
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A radial IR steady-state free precession technique combined with a principal component based iterative algorithm are demonstrated for rapid high-resolution abdominal T1 mapping. This method yields high quality T1 maps for 10 slices with spatial resolution as high as of 0.83x0.83x3mm from data acquired in a breath-hold or a short free-breathing scan. The method is a significant improvement over existing abdominal T1 mapping techniques. |
| 517 | 14:33
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Evaluation of Four T1 Mapping Sequences for Obtaining the Extracellular Volume Fraction in Abdominal Imaging |
1Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 2Indiana University School of Medicine, Indianapolis, IN, United States, 3Radiology and Clinical Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 4MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany, 5MR R&D Collaborations, Siemens Medical Solutions USA, Inc, Chicago, IL, United States, 6Siemens Medical Solutions, USA Inc, Chicago, IL, United States |
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Many different T1 mapping sequences and extracellular volume (ECV) fraction have proven to be useful tools for evaluation of tissue fibrosis, however their potential has not been explored in abdominal imaging. We evaluated 4 different T1 mapping techniques; Dual-flip angle VIBE (DFA VIBE), MOLLI, SASHA and IR-SNAPSHOT and obtained similar ECV fractions of the liver and pancreas. DFA VIBE has the highest spatial coverage in 1 breath hold but suffers from inhomogeneous T1 in the aortic blood. IR-SNAPSHOT has advantage of not requiring cardiac gating and provides the most homogenous T1 of the blood within the aorta. |
| 518 | 14:45
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Automated liver-segment localization and segmental hepatic proton-density fat fraction measurement |
1Radiology, University of California, San Diego, La Jolla, CA, United States, 2Biomedical Informatic, University of California, San Diego, La Jolla, CA, United States |
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Hepatic proton-density fat fraction (PDFF) has emerged as an imaging biomarker for liver fat content in non-alcoholic fatty liver disease. To account for the spatial heterogeneity of liver fat, one approach is to manually place a region of interest (ROI) and estimate the PDFF in each hepatic Couinaud segment separately. We trained a convolutional neural network to automatically locate each liver segment and calculate segmental PDFF values. We show that segmental PDFF measurement based on our automated approach closely matches those based on manual placement by a trained image analyst, demonstrating the feasibility of utilizing CNNs to automatically extract clinically valuable quantitative information from source images. |
| 519 | 14:57
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Assessment of hepatic fibrosis and steatosis in pediatric non-alcoholic fatty liver disease using multifrequency MR elastography |
1Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 22Center for Chronically Sick Children, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany |
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Multifrequency MR elastography MRE was applied to detect fibrosis and steatosis, two pathological features associated with pediatric non-alcoholic fatty liver disease (NAFLD). Shear wave speed (c) obtained from MRE is a measure of tissue stiffness and can differentiate moderate from advanced fibrosis. Penetration rate (a) as another MRE parameter is able to detect moderate steatosis and is negatively correlated with hepatic fat fraction. Both MRE derived mechanical parameters c and a are independently responsive to fibrosis and steatosis and could be used in the future as imaging markers for the noninvasive assessment of prediatric NAFLD. |
| 520 | 15:09
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Can Negligible Hepatic Steatosis Determined by MRI-Proton Density Fat Fraction Obviate the Need for Liver Biopsy in Potential Liver Donors? |
1UHN, Toronto, ON, Canada |
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Hepatic steatosis in potential liver donor candidates has important implications towards outcomes of liver transplant recipients and donor safety. Hepatic steatosis in potential donors in excess of established but varying institutional thresholds are considered as grounds for donor ineligibility. However, negiblible/absent hepatic steatosis (<5%) is considered acceptable universally. Currently Liver biopsy is regarded as reference standard. We show in our study that MR-PDFF has very high NPV for excluding significant hepatic steatosis (>10%). Thus MRI-PDFF can be utilized for liver donor screening and obviates the need for liver biopsy when MRI-PDFF values are <5% |
| 521 | 15:21
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Intravoxel Incoherent Motion Diffusion-weighted MRI for Assessing Necroinflammation in Patients with Chronic Liver Disease |
1Centre de recherche du centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada, 2MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, 3Department of Radiology, Radio-Oncology and Nuclear Medicine, Université de Montréal, Montreal, QC, Canada, 4Department of Gastroentology and Hepatology, Université de Montréal, Montreal, QC, Canada, 5Department of Medicine, Division of Gastroenterology, McGill University Health Centre (MUHC), Montreal, QC, Canada, 6Department of Pathology, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada, 7Department of Pathology and Cellular Biology, Université de Montréal, Montreal, QC, Canada |
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Necroinflammation is a hallmark feature in several causes of chronic liver disease. Because it has multiple tissue contrast mechanisms, MRI is ideally suited for characterization of histopathological changes (i.e. inflammation, fat, iron, and fibrosis) that may occur concomitantly in chronic liver disease. We evaluated intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) MRI for assessment of necroinflammation. Perfusion fractions were significantly correlated with necroinflammation grades (ρ = 0.49, P < 0.0001) and could discriminate grades ≤ A1 vs. ≥ A2 and ≤ A2 vs. A3 with good accuracy (AUC: 0.81 and 0.80, respectively). Our results suggest that perfusion fraction may be used for assessing liver necroinflammation. |
| 522
|
15:33
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Free-Breathing Hepatic Fat Quantification in Children and Infants Using a 3D Stack-Of-Radial Technique: Assessment of Accuracy and Repeatability |
1Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, 2Physics and Biology in Medicine, University of California Los Angeles, Los Angeles, CA, United States, 3Pediatrics, Division of Neonatology, David Geffen School of Medicine, University of California Los Angeles, Mattel Children's Hospital, Los Angeles, CA, United States, 4Biomedical Engineering, Tsinghua University, Beijing, China |
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Non-alcoholic fatty liver disease (NAFLD) has increasing prevalence in children and early risk factors for NAFLD may be present during infancy. MRI can non-invasively quantify hepatic fat, but current techniques require breath-holding (BH), which is not possible in many children and infants. In this study, a novel free-breathing (FB) 3D stack-of-radial fat quantification technique was developed and evaluated in children and infants. The proposed FB technique achieved accurate and repeatable hepatic fat quantification and improved image quality compared to conventional BH techniques. This FB technique can potentially improve the diagnosis and monitoring of NAFLD in children and infants. |
| W03/04 | Tuesday 13:45 - 15:45 | Moderators: Serena Counsell & Claire Kelly |
| 523 | 13:45
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Emerging Metabolic Trajectories in the Developing Fetal Brain |
1Developing Brain Research Laboratory, Children's National Health System, Washington, DC, United States, 2Diagnostic Imaging and Radiology, Children's National Health System, Washington, DC, United States, 3Pediatrics, The George Washington University School of Medicine, Washington, DC, United States |
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Knowledge of metabolite changes in the fetal brain will provide insight into the biochemical changes in the developing brain. Findings from measurement of metabolite concentration as a function of increasing GA are reported. Significant increases in NAA, Cr, Cho and scyllo-Inositol with increasing GA in the fetal brain was observed in this study. Changes in myo-Inositol with GA did not reach significance. |
| 524 | 13:57
|
Developmental Score of the Neonatal Brains: Characterizing Diffusion MRI Changes in the Term- and Preterm-born Infants |
1Radiology, Johns Hopkins University School of Medicine, BALTIMORE, MD, United States, 2Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, BALTIMORE, MD, United States, 3Laboratory Medicine, Children’s and Women’s Health, Norwegian University of Science and Technology, Trondheim, Norway |
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Postmenstrual age (PMA) is used as a time-scale to evaluate brain development, but it contains inaccuracy with regards to the estimated time of conception because the duration from the last menstrual period to conception varies. To address this variation, we designed a developmental score (DevS) that aligned individuals with similar development patterns together, and provides a linear trajectory of DTI-measurement as a function of an underlying brain developmental index. Compared to PMA, DevS showed an improved the regression with DTI-measurements, and it better separated the developmental differences between term- and preterm-born infants. |
| 525 | 14:09
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Quantitative assessment of pediatric brain myelination in a clinical setting using macromolecular proton fraction |
1Radiology, University of Washington, Seattle, WA, United States, 2Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russian Federation, 3Radiology, First Children's Hospital, Tomsk, Russian Federation |
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The fast macromolecular proton fraction (MPF) mapping method has been implemented as a part of a clinical pediatric MRI protocol for a 1.5T MRI scanner. 3D MPF maps were obtained from 31 pediatric patients aged from 2 weeks to 7 years without abnormal brain findings. MPF maps allowed robust quantitation of age-related changes in the myelin content. Temporal trajectories of regional brain myelination were analyzed using the general logistic model that enabled the formal description of distinctions in the onset and speed of myelination across a range of white and gray matter structures. |
| 526 | 14:21
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MR Fingerprinting enables quantitative measures of brain tissue relaxation times and myelin water fraction in early brain development |
1Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2Chang Gung University College of Medicine, Kaohsiung, Taiwan |
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In this study, a high-resolution MR Fingerprinting technique was developed for rapid and simultaneous quantification of T1, T2 and myelin water fraction in pediatric neuroimaging. The method was applied to five subjects from 3 months to 52 months old and high quality quantitative maps were obtained from all subjects without evident motion artifacts. Our preliminary results also show a trend of decrease in T1/T2 and increase of myelin water fraction with age, which are consistent with finding in literature. |
| 527 | 14:33
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Patterns of subcortical gray matter and white matter myelination from 4.5 months to 1 year-old: an observational study comparing the whole brain T1w/T2w ratio myelin mapping technique and an autopsy infant myelin-staining study |
1Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia, 2Neuroscience Research, Murdoch Children's Research Institute, Melbourne, Australia, 3Neurosurgery, The Royal Children's Hospital, Melbourne, Australia, 4Medical Imaging, The Royal Children's Hospital, Melbourne, Australia, 5Paediatrics, University of Melbourne, Melbourne, Australia, 6Radiology, University of Melbourne, Melbourne, Australia, 7Epilepsy, Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, 8Neurology, The Royal Children's Hospital, Melbourne, Australia, 9Victorian Infant Brain Study (VIBeS), Murdoch Children's Research Institute, Melbourne, Australia, 10Medicine, Monash University, Melbourne, Australia |
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The whole brain T1w/T2w ratio technique enables in vivo quantitative myelin mapping using clinically acquired MRI sequences, which is potentially useful when investigating developmental myelination trajectories. Post-mortem infant myelin-staining studies provide useful references. This study characterizes myelination trajectories of 27 subcortical brain regions in typically developing 4.5 months to 1 year-old children using the T1w/T2w ratio technique and compared the patterns with those demonstrated by an autopsy infant myelin-staining study. Similar myelination trajectory patterns were observed in the structures that commenced myelination before birth. This highlights the T1w/T2w ratio as potential myelin imaging biomarker for these structures during this period. |
| 528 | 14:45
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Profiling myelin maturation with quantitative susceptibility mapping (QSM) in pediatric brains |
1Brain Imaging and Analysis Center, Duke University, Durham, NC, United States |
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Quantitative susceptibility mapping (QSM) has been increasingly used to access brain development, especially white matter myelination. In this study, diffusion tensor imaging (DTI) has been used to delineate the corpus callosum in the pediatric brains, followed by tract-based QSM analysis to accurately derive the baseline susceptibility across subjects. The baseline susceptibility is then used to evaluate white matter and myelin development. |
| 529 | 14:57
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Neonate functional brain networks and distinctive intra-network connectivity |
1Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 2Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 3Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States, 4Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China |
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Little is known on the network organization in the neonatal brain. Here, we used a novel parcellation method, called regularized-Ncut (RNcut), to parcellate the neonate brain into functional networks with resting-state fMRI. RNcut effectively delineates the neonatal functional networks including the primary sensorimotor and higher-order networks. Based on RNcut parcellation of functional networks, intra-network connectivity was quantified. Distinctive intra-network connectivity was revealed for the first time. We found that the primary sensorimotor network has the highest intra-network connectivity while |
| 530 | 15:09
|
Prenatal Maternal Cortisol Response Predicts One-month Infant White Matter Microstructure |
1Waisman Center, University of Wisconsin Madison, Madison, WI, United States, 2Psychology, University of Wisconsin Madison, Madison, WI, United States, 3Center for Healthy Minds, University of Wisconsin Madison, Madison, WI, United States, 4Psychiatry, University of Wisconsin Madison, Madison, WI, United States, 5Medical Physics, University of Wisconsin Madison, Madison, WI, United States |
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Exposure to differing concentrations of cortisol likely has a significant impact on brain development in childhood and adolescence; however, little is known about the time immediately following birth. Using multi-shell diffusion imaging data, we examined the associations between prenatal maternal diurnal cortisol patterns and infant white matter microstructure. Infant measures were associated with the slope of the maternal cortisol response across white matter, suggesting variations of cortisol within the intrauterine environment may have a significant influence on processes of early brain development. |
| 531 | 15:21
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Influence of Infant Feeding on Longitudinal Brain and Cognitive Development |
1Pediatrics, Brown University, Providence, RI, United States, 26Waisman Center, University of Wisconsin, Madison, WI, United States, 3Pediatrics, Memorial Hospital of Rhode Island, Providence, RI, United States |
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Infancy and early childhood are sensitive and rapid periods of brain growth that coincide with the emergence of nearly all cognitive, behavioral, and social-emotional functions. Brain growth, including myelination, is modulated modulated by neural activity and are responsive to environmental, genetic, hormonal, and other influences, including nutrition. He we use longitudinal neuroimaging to examine the influence of early infant nutrition, specifically breastfeeding, on brain and cognitive development. |
| 532 | 15:33
|
Early specific connections of the Visual Word Form Area during the first year of reading instruction: a longitudinal MRI study in children |
1INSERM, Gif-sur-Yvette, France, 2INSERM, Paris, France, 3CEA, Gif-sur-Yvette, France, 4University College London, London, United Kingdom, 5College de France, Paris, France, 6CNRS, Gif-sur-Yvette, France |
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Specialized in word recognition, the visual word form area (VWFA) is located in the posterior fusiform gyrus of the left hemisphere, regardless of one’s writing system. To test the hypothesis that this consistent location is determined by specific connections to linguistic regions, we studied 6-7year old children throughout the process of learning to read. Using diffusion and functional MRI, we analysed the white-matter connectivity of cortical regions processing visual categories (words, houses, faces, tools). We showed that the emerging VWFA has specific and stable connections to the inferior-dorsal parietal cortex, and these connections exhibit microstructural maturation related to reading improvement. |
| W07 | Tuesday 14:45 - 15:45 | (no CME credit) |
| W08 | Tuesday 14:45 - 15:45 | (no CME credit) |
| Exhibition Hall 1765-1802 | Tuesday 16:15 - 18:15 | (no CME credit) |
| Exhibition Hall | Tuesday 16:15 - 17:15 | (no CME credit) |
| Exhibition Hall | Tuesday 16:15 - 17:15 | (no CME credit) |
Organizers: Maxime Descoteaux, Ivana Drobnjak, Shawna Farquharson, Andrada Ianus
| N04 | Tuesday 16:15 - 18:15 | Moderators: Tim Dyrby | (no CME credit) |
16:15
|
Clinical Power Pitch: The Role of Diffusion MRI in Diagnosing & Monitoring Multiple Sclerosis | |
16:23
|
Clinical Power Pitch: The Challenges of Neurosurgical Intervention for Tumour Management | |
| TBD |
16:31
|
Clinical Power Pitch: The Challenges of the First 1000 Days of Life & Role of DWI in the Assessment of the Developing Brain | |
1Boston Children's Hospital, United States |
16:39
|
Clinical Power Pitch: The Role of Diffusion MRI in Quantifying Tumour Microstucture | |
| TBD |
16:47
|
Clinical Power Pitch: The Importance & Challenges of Neuroimaging in Dementia | |
| TBD |
16:55
|
MR Scientist Power Pitch: The Advantages of Using AFD to Study Neurodegeneration in Clinical Populations | |
17:03
|
MR Scientist Power Pitch: Multi-Dimensional Diffusion for Brain Imaging | |
1Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden |
17:11
|
MR Scientist Power Pitch: The Potential of G-Ratio Mapping in MS | |
1McGill University, Canada |
17:19
|
MR Scientist Power Pitch: Imaging of Cancer Cell Size & Cellularity Using Temporal Diffusion Spectroscopy | |
1Vanderbilt University |
17:27
|
MR Scientist Power Pitch: White Matter Tract Integrity Modelling & Its Applications | |
1Radiology, NYU School of Medicine, New York, NY, United States |
17:35
|
Discussion |
Organizers: Giulia Ginami, Tim Leiner, Michael Salerno
| S05 | Tuesday 16:15 - 18:15 | (no CME credit) |
16:15
|
Past, Present & Future of Cardiac MRI: Clinical Insights | |
16:40
|
Speeding Up: Acceleration Techniques for Cardiac MRI | |
1ECE, University of Minnesota, Minneapolis, MN, United States |
17:00
|
Sharpening: Motion Correction in Cardiac MRI | |
1King's College London |
17:20
|
Quantifying 1: Tissue Characterization: Novel Approaches to Cardiac MRI Relaxometry | |
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States |
17:40
|
Quantifying 2: Tissue Characterization: Cardiac Magnetic Resonance Fingerprinting | |
1Case Western Reserve University, United States |
18:00
|
Panel Discussion |
Organizers: Marcus Alley, Bernd Jung
| S01 | Tuesday 16:15 - 18:15 | Moderators: Bernd Jung & Matthias Weigel |
16:15
|
Spin Echo Imaging | |
1GE Healthcare, United States |
17:15
|
Gradient Echo Imaging | |
1Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany |
||
Magnetic resonance imaging (MRI) techniques can usually be classified into spin-echo (SE) and gradient-echo (GRE) pulse sequences. In this presentation, the basic physical principles of GRE imaging, as well as different mechanisms to generate image contrast will be explained. Differences between SE and GRE MRI will be discussed. Additionally, the influence of different pulse sequence parameters (e.g. echo time, repetition time, flip angle; as well as spoiling techniques and preparation pulses) on the image contrast will be covered. Clinical applications of GRE imaging techniques will be shown exemplarily. |
18:15
|
Adjournment & Meet the Teachers |
Organizers: Eric Chang, Garry Gold, Emily McWalter, Edwin Oei, Philip Robinson
| S03 | Tuesday 16:15 - 18:15 | Moderators: Jenny Bencardino & James Linklater |
16:15
|
MR-US Fusion in MSK Interventions | |
The basic principles of MR-US fusion and potential applications to the musculoskeletal system will be discussed. Development of a simple phantom for training will be described. Examples of injections performed to date will be shown to illustrate potential applications and challenges in obtaining adequate registration. |
16:55
|
MR-Guided Focused Ultrasound: Musculoskeletal Applications and Research Highlights | |
1Radiology and Biomedical Imaging, University of California, San Francisco, United States |
||
Overview of clinical indications, research highlights, and future directions of musculoskeletal applications of magnetic resonance-guided focused ultrasound. |
17:35
|
Non-Oncologic MSK PET-MR | |
1Stanford University, United States |
||
New PET-MRI systems promise to combine high-resolution morphologic MR imaging with simultaneous functional information from PET to potentially provide a complete imaging modality for studying musculoskeletal disease. This educational talk will discuss emerging applications of PET-MRI in non-oncologic musculoskeletal disease and comparative advantages of PET-MRI over hybrid PET-computed tomography (PET/CT) systems or MRI alone. Technical considerations and challenges as they specifically relate to PET-MRI of musculoskeletal disease will also be discussed. |
18:15
|
Adjournment & Meet the Teachers |
| Power Pitch Theater A - Exhibition Hall | Tuesday 16:15 - 17:15 | Moderators: Chunlei Liu & Samuel Hurley | (no CME credit) |
| 533 | 16:15
|
On the Sensitivity of Bone Marrow Magnetic Susceptibility and R2* on Trabecular Bone Microstructure |
1Diagnostic and Interventional Radiology, Technical Univeristy of Munich, Munich, Germany, 2Institute of Medical Engineering, Technical University of Munich, Munich, Germany, 3Philips Research Laboratory, Hamburg, Germany, 4Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, Munich, Germany |
| 534
|
16:15
|
Pushing the limits of short-T2 MRI: 200 mT/m gradient strength and 2 MHz bandwidth |
1Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Zurich, Switzerland |
| 535 | 16:15
|
New post-processing methods for simultaneous measurement of R2, R2', R2*, QSM, positive and negative susceptibility maps using mGESFIDE acquisition |
1Department of electrical and computer engineering, Seoul National University, Seoul, Republic of Korea, 2Department of Biomedical Engineering, Hankuk University of Foreign Studies, Gyeonggi-do, Republic of Korea |
| 536
|
16:15
|
Repeatability and Reproducibility of a New Method for Quantifying Triglyceride Saturation Using Bipolar Multi-Echo MRI |
1Pattern Recognition Lab, Department of Computer Science, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 2Radiology, Duke University Medical Center, Durham, NC, United States, 3Center for Advanced Magnetic Resonance Development, Duke University Medical Center, Durham, NC, United States, 4MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, 5MR R&D Collaborations, Siemens Healthineers, Cary, NC, United States |
| 537 | 16:15
|
Calibrating variable flip angle (VFA)-based T1 maps: when and why a simple scaling factor is justified |
1CAMH, Toronto, ON, Canada |
| 538 | 16:15
|
“In vivo” Field-Cycling relaxometry of tumours. Evidence for the role of the intracellular water lifetime as tumour biomarker. |
1University of Torino, Torino, Italy, 2University of torino, Torino, Italy, 3Stelar srl, Mede (PV), Italy |
| 539 | 16:15
|
In-vivo Vagus Nerve to Central Nervous System Tracing using Manganese Enhanced Magnetic Resonance Imaging |
1Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 2Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States |
| 540
|
16:15
|
Fat Quantification Using A High-Resolution Bipolar Gradient Water-Fat Sequence |
1Medical Biophysics, Western University, London, ON, Canada, 2Robarts Research Institute, Western University, London, ON, Canada, 3Obstetrics and Gynaecology, Western University, London, ON, Canada, 4Physiology and Pharmacology, Western University, London, ON, Canada |
| 541
|
16:15
|
Robust Fat-water Separation using Binary Decision Tree Algorithm |
1Huazhong University of Science and Technology, Wuhan, China, 2Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences, Shen Zhen, China, 3University of Chinese Academy of Sciences, Beijing, China |
| 542
|
16:15
|
Human In-vivo Brain MR Current Density Imaging (MRCDI) based on Steady-state Free Precession Free Induction Decay (SSFP-FID) |
1Center for Magnetic Resonance, DTU Elektro, Technical University of Denmark, Kgs. Lyngby, Denmark, 2Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark, 3Department of Neurology, Copenhagen University Hospital, Bispebjerg, Denmark, 4High-Field Magnetic Resonance Center, Max-Planck-Institute for Biological Cybernetics, Tübingen, Germany, 5German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 6Department of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany |
| 543 | 16:15
|
Multi-receiver coil combination for breast phase-based Electrical Property Tomography Using B1- estimation |
1electrical electronic engineering, Yonsei University, seoul, Republic of Korea, 2Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea |
| 544
|
16:15
|
Electrical permittivity imaging at 3T: a precision and accuracy study of three $$$ \it{B_1^+}$$$ mapping techniques |
1Department of Radiotherapy, University Medical Center Utrecht, Utrecht, Netherlands, 2Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, 3Department of Radiation Oncology, Academic Medical Center Amsterdam, Amsterdam, Netherlands |
| 545 | 16:15
|
Multi-frequency MREIT Demonstrated using Semipermeable Membrane Models |
1SBHSE, Arizona State University, Tempe, AZ, United States, 2ECEE, Arizona State University, Tempe, AZ, United States |
| 546 | 16:15
|
The impact of CSF pulsation on reconstructed brain conductivity |
1Philips Research Europe, Hamburg, Germany, 2Hokkaido University Hospital, Sapporo, Japan |
| 547 | 16:15
|
In Vivo Conductivity Imaging of Tissue Response after Radiation Therapy |
1Division of RI Convergence Research, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea, 2Biomedical Engineering, Kyung Hee University, Seoul, Republic of Korea, 3Radiology, Chonnam National University Medical School, Gwangju, Republic of Korea, 4Konkuk University, Seoul, Republic of Korea |
| Power Pitch Theater B - Exhibition Hall | Tuesday 16:15 - 17:15 | Moderators: Manus Donahue & Ji Eun Park | (no CME credit) |
| 548 | 16:15
|
Rethinking vascular artifacts: testing the sensitivity of ASL vascular signal as a biomarker of disease |
1Rochester Institute of Technology, Rochester, NY, United States, 2Helmholtz-Zentrum Dresden-Rossendorf Institut für Radiopharmazeutische Krebsforschung PET-Zentrum, Dresden, Germany, 3The University of Alabama at Birmingham, Birmingham, AL, United States, 4Columbia University Medical Center, New York, NY, United States |
| 549 | 16:15
|
Exploiting small fluctuations in labeling efficiency in pseudo-continuous arterial spin labeling for combined flow-territory determination and CBF-mapping |
1Department of Radiology, Leiden University Medical Center, Leiden, Netherlands |
| 550 | 16:15
|
The Influence of the cardiac cycle on velocity-selective and acceleration-selective Arterial Spin Labeling |
1C.J. Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands, 2Imaging Division, University Medical Center Utrecht, Utrecht, Netherlands |
| 551
|
16:15
|
Improving Arterial Spin Labeling using Deep Learning |
1Department of Bio and Brain Engineering, Korea Advanced Institute of Science & Technology (KAIST), Daejeon, Republic of Korea, 2Department of Radiology, Seoul National University College of Medicine, Seoul, Korea, Democratic People's Republic of |
| 552
|
16:15
|
Contrast Enhancement for Early Tumor Detection by Active-Feedback Field Locking and Refocusing |
1Chemistry & Biochemistry, University of California, Los Angeles, Los Angeles, CA, United States |
| 553 | 16:15
|
Measurement of artifact-free arterial input functions for T1-weighted dynamic contrast-enhanced MRI: Inter- and intra-patient variability |
1Department of Biomedical Imaging Science, University of Leeds, Leeds, United Kingdom, 2Department of Medical Physics, German Oncology Centre, Limassol, Cyprus, 3Department of Medical Physics & Engineering, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 4Department of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom |
| 554 | 16:15
|
Estimation of Pharmacokinetic Parameters in Dynamic Contrast Enhanced MRI via Random Forest Regression |
1Computer Science, Technical University of Munich, Munich, Germany, 2Neuroimaging Sciences, University of Edinburgh, Edinburgh, United Kingdom, 3Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, 4Institute for Digital Communication, University of Edinburgh, Edinburgh, United Kingdom, 5Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom |
| 555 | 16:15
|
Influence of whole-brain DCE-MRI (k,t) sampling strategies on variance of pharmaco-kinetic parameter estimates |
1Electrical Engineering Department, University of Southern California, Los Angeles, CA, United States |
| 556 | 16:15
|
Characterization of Breast Lesion using T1-perfusion MRI: Semi- Quantitative Vs Quantitative Analysis |
1Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, 2Department of Biomedical Engineering, AIIMS Delhi, New Delhi, India, 3Department of Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, New Delhi, India |
| 557 | 16:15
|
Manganese-enhanced MRI: comparison of agents in the rat pancreas |
1Edinburgh Imaging, The University of Edinburgh, Edinburgh, United Kingdom, 2Experimental Medicine Imaging, GlaxoSmithKline, London, United Kingdom, 3Endocrinology Unit, The University of Edinburgh, Edinburgh, United Kingdom, 4BHF/University of Edinburgh Centre for Cardiovascular Sciences, The University of Edinburgh, Edinburgh, United Kingdom |
| 558
|
16:15
|
Novel contrasts at +2.7 ppm, +1.2 ppm, and -1.7 ppm investigated in vivo with high spectral resolution CEST MRI in the human brain at 9.4T |
1High-field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany |
| 559 | 16:15
|
A Novel MR Fingerprinting Approach for Fast Quantitative Chemical Exchange Saturation Transfer MRI Analysis by Subgrouping Proton Exchange Models (CEST-SPEM) |
1Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States |
| 560 | 16:15
|
Evaluating Feasibility of Creatine-weighted CEST MRI in Human Brain at 7T using Z-spectral Fitting Approach |
1Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, 2Biomedical Engineering, AIIMS Delhi, New Delhi, India, 3Sidra Medical and Research Center, DOHA, Qatar, 4Radiology, University of Illinois at Chicago, Chicago, IL, United States, 5Radiology, University of Pennsylvania, Philadelphia, PA, United States |
| 561 | 16:15
|
CO2 induced pHi changes in the brain of polar fish: a TauCEST application |
1University of Bremen, Bremen, Germany, 2Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research, Bremerhaven, Germany |
| 562 | 16:15
|
Characterizing the sensitivity of ihMT for various dipolar relaxation times (T1D) at high RF power using frequency-alternated and cosine-modulated RF pulses for dual frequency-offset saturation |
1Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 3Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical Schooll, Boston, MA, United States |
Organizers: Reza Nezafat, Tim Leiner
| S02 | Tuesday 16:15 - 18:15 | Moderators: René Botnar & Zahi Fayad |
16:15
|
MRI of Atherosclerosis of Various Vascular Beds in the Era of Artificial Intelligence | |
1University of Washington, United States |
16:45
|
Towards 3D & 4D Comprehensive CMR | |
1University Hospital Lausanne, Switzerland |
||
Imaging of the heart remains time consuming, operator dependent, and inefficient. New paradigms that combine modern image acquisition and reconstruction strategies promise significantly improved ease-of-use and time efficiency. These are critical ingredient for a more wide-spread adoption and improved clinical impact of cardiac MR in general. |
| 563 | 17:15
|
LGE-CMR derived texture features reflect poor prognosis in hypertrophic cardiomyopathy patients with systolic dysfunction: preliminary results |
1Peking Union Medical College, Beijng, China, 2CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China |
||
In this study, we evaluated the prognostic value of texture features based on late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) images in hypertrophic cardiomyopathy (HCM) patients with systolic dysfunction. 1.5 T CMR cine and LGE images were performed on 67 HCM patients with systolic dysfunction. Texture features were extracted from LGE images. Cox proportional hazard analysis and Kaplan-Meier analysis were used to determine the association of texture features with event free survival. The result showed that increased LGE heterogeneity (higher X0_GLRLM_energy, higher X1_H_uniformity, lower X0_H_skewness and lower X0_GLCM_cluster_tendency) was associated with adverse events in HCM patients with systolic dysfunction. |
| 564
|
17:27
|
Cardiac MRI measured left atrial function can identify patient with pulmonary hypertension due to left heart disease. |
1Academic Radiology, The University of Sheffield, Sheffield, United Kingdom, 2Radiology, Sheffield Teaching Hospitals, Sheffield, United Kingdom, 3Sheffield Pulmonary Vascular Disease Unit, Sheffield Teaching Hospitals, Sheffield, United Kingdom |
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Patients with left heart disease commonly develop pulmonary hypertension (PH) [1], initially due to passive backward transmission of high left ventricular filling pressures through the pulmonary circulation. Assessment of left atrial reservoir and pump function using changes in left atrial area over time are useful to differentiate patients with left heart disease from other cases of suspected pulmonary hypertension (Mann-Whitney u test p-value 0.0015 and 0.0067 respectively). |
| 565 | 17:39
|
All-In-One MRI of Atherosclerosis: Towards Higher Clinical Value |
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Department of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, 4Department of Radiology, Anzhen Hospital, Capital Medical University, Beijing, China |
||
Multi-contrast MRI is a promising yet under-utilized imaging modality for evaluating the disease status of atherosclerosis. Major drawbacks of conventional protocols include long complex scan procedures and variability in image interpretation due to the qualitative nature of the images. In this |
| 566
|
17:51
|
MR Imaging Biomarkers of Cardiac Function and Rotational Mechanics in Boys with Duchenne Muscular Dystrophy |
1Department of Bioengineering, University of California, Los Angeles, CA, United States, 2Department of Radiology, University of California, Los Angeles, CA, United States, 3Department of Medicine (Cardiology), University of California, Los Angeles, CA, United States, 4Department of Internal Medicine/Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, United States, 5Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United States |
||
Duchenne Muscular Dystrophy (DMD) severely impacts heart health. Decreasing LV ejection fraction (EF) is a late and highly variable outcome in this cohort. Earlier indications of cardiac involvement would improve patient management and provide insight into the utility of emerging therapy. Boys with DMD (N=25) and healthy volunteers (N=8) underwent cardiac MRI exams including short-axis tagged images. EF, peak LV twist, and peak mid-wall circumferential strain (Ecc) were estimated. Ecc and twist were significantly reduced in patients (9.3°±4.3° vs. 14.8°±3.6°, p< 0.004) and (-15.8±5.8% vs. -18.5±3.2%, p<0.02). Whereas, EF was not significantly different between groups. ~50% of DMD patients with normal EF had reduced twist and Ecc. Reduced peak LV twist and mid-wall Ecc measured by MR tagging may be earlier and more sensitive indicators of cardiac involvement in boys with DMD. |
| 567 | 18:03
|
Assessment Pre- and Post-Ablation Energetics and Vortex Size Alterations of Left Atrial Hemodynamics in Patients with Paroxysmal Atrial Fibrillation: 4D flow MRI Study |
1Cardiac Sciences - Stephenson Cardiac Imaging Centre, University of Calgary, Calgary, AB, Canada, 2University of Calgary, Calgary, AB, Canada, 3Western University, London, ON, Canada, 4Carleton University, Ottawa, ON, Canada, 5University of Ottawa, Ottawa, ON, Canada |
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This study may be of interest for clinicians and researchers who study left atrial diseases and arrhythmias. This study demonstrated a significant decrease of flow energetics and vortex size in patients with history of atrial fibrillation. |
18:15
|
Adjournment & Meet the Teachers |
| N01 | Tuesday 16:15 - 18:15 | Moderators: Shanshan Wang & Florian Knoll |
| 568
|
16:15
|
A Multi-scale Deep ResNet for Radial MR Parameter Mapping |
1Electrical and Computer Engineering, University of Arizona, Tucson, AZ, United States, 2Department of Medical Imaging, University of Arizona, Tucson, AZ, United States, 3Biomedical Engineering, University of Arizona, Tucson, AZ, United States |
||
Quantitative mapping of MR parameters has shown great potential for tissue characterization but long acquisition times required by conventional techniques limit their widespread adoption in the clinic. Recently, model-based compressive sensing (CS) reconstructions that produce accurate parameter maps from a limited amount of data have been proposed but these techniques require long reconstruction times making them impractical for routine clinical use. In this work, we propose a multi-scale deep ResNet for MR parameter mapping. Experimental results illustrate that the proposed method achieves reconstruction quality comparable to model-based CS approaches with orders of magnitude faster reconstruction times. |
| 569
|
16:27
|
Transfer learning for reconstruction of accelerated MRI acquisitions via neural networks |
1Electrical and Electronics Engineering, Bilkent University, Ankara, Turkey, 2National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey, 3Neuroscience Graduate Program, Bilkent University, Ankara, Turkey |
||
Neural network architectures have recently been proposed for reconstruction of undersampled MR acquisitions. These networks contain a large number of free parameters that typically have to be trained on orders-of-magnitude larger sets of fully-sampled MRI data. In practice, however, large datasets comprising thousands of images are rare. Here, we propose a transfer-learning approach to address the problem of data scarcity in training deep networks for accelerated MRI. Results show that networks obtained via transfer-learning using only tens of images in the testing domain achieve nearly identical performance to networks trained directly in the testing domain using thousands of MR images. |
| 570 | 16:39
|
DeepSPIRiT: Generalized Parallel Imaging using Deep Convolutional Neural Networks |
1Radiology, Stanford University, Stanford, CA, United States, 2Electrical Engineering, Stanford University, Stanford, CA, United States |
||
A parallel-imaging algorithm is proposed based on deep convolutional neural networks. This approach eliminates the need to collect calibration data and the need to estimate sensitivity maps or k-space interpolation kernels. The proposed network is applied entirely in the k-space domain to exploit known properties. Coil compression is introduced to generalize the method to different hardware configurations. Separate networks are trained for different k-space regions to account for the highly non-uniform energy. The network was trained and tested on both knee and abdomen volumetric Cartesian datasets. Results were comparable to L2-ESPIRiT and L1-ESPIRiT which required calibration data from the ground truth. |
| 571 | 16:51
|
Inception-CS: Deep Learning For Sparse MR Reconstruction in Glioma Patients |
1University of California San Francisco, San Francisco, CA, United States, 2Columbia University Medical Center, New York, NY, United States, 3University of California Irvine, Irvine, CA, United States, 4Hofstra Northwell School of Medicine, Manhasset, NY, United States |
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Sparse MR image reconstruction through deep learning represents a promising novel solution with early results suggesting improved performance compared to standard techniques. However, given that neural networks reconstruct using a learned manifold of rich image priors, it is unclear how the algorithm will perform when exposed to pathology not present during network training. In this study we: (1) present a novel Inception-CS architecture for reconstruction using extensive residual Inception-v4 modules; (2) demonstrate state-of-the-art reconstruction performance in glioma patients however only when representative pathology is available during algorithm training. |
| 572 | 17:03
|
Deep learning MR reconstruction with Automated Transform by Manifold Approximation (AUTOMAP) in real-world acquisitions with imperfect training |
1A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 2Department of Physics, Harvard University, Cambridge, MA, United States |
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Automated Transform by Manifold Approximation (AUTOMAP) is a generalized MR image reconstruction framework based on supervised manifold learning and universal function approximation implemented with a deep neural network architecture. Here we investigate the effect of significant sampling trajectory error in spiral acquisitions, where mismatch between training and runtime scanner trajectories may result in unpredictable reconstruction artifacts. We demonstrate through Monte Carlo analysis that the error in AUTOMAP reconstruction increases smoothly as a function of trajectory error, demonstrating reasonable robustness to trajectory deviation. We find these simulation results are consistent with reconstruction performance on real scanner data acquired from human subjects. |
| 573 | 17:15
|
Deep Generative Adversarial Neural Networks for Compressed Sensing (GANCS) Automates MRI |
1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Electrical Engineering, Stanford University, stanford, CA, United States, 3Stanford University, stanford, CA, United States, 4Radiology, Stanford University, Stanford, CA, United States, 5Radiation Oncology, Stanford University, Stanford, CA, United States, 6Stanford University, Stanford, CA, United States |
||
MRI suffers from aliasing artifacts when undersampled for real-time imaging. Conventional compressed sensing (CS) is not however cognizant of image diagnostic quality, and substantially trade-off accuracy for speed in real-time imaging. To cope with these challenges we put forth a novel CS framework that permeates benefits from generative adversarial networks (GAN) to modeling a manifold of MR images from historical patients. Evaluations on a large abdominal MRI dataset of pediatric patients by expert radiologists corroborate that GANCS retrieves improved images with finer details relative to CS-MRI and deep learning schemes with pixel-wise costs, at 100 times faster speed than CS-MRI. |
| 574 | 17:27
|
ReconNet: A Deep Learning Framework for Transforming Image Reconstruction into Pixel Classification |
1Monash Biomedical Imaging, Monash University, Melbourne, Australia, 2School of Psychological Sciences, Monash University, Melbourne, Australia, 3Department of Electrical and Computer System Engineering, Monash University, Melbourne, Australia, 4Institute of Medicine, Research Centre Juelich, Juelich, Germany |
||
A deep learning framework is presented that transforms the image reconstruction problem from under-sampled k-space data into pixel classification. The underlying target image is represented by a quantized image, which makes it possible to design a network that classifies each pixel to a quantized level. We have compared two deep learning encoder-decoder networks with the same complexity: one is a classification network and the other is a regression network. Even though the complexity of both the networks is the same, the images reconstructed using the classifier network have resulted in a six times improvement in the mean squared error compared to the regression network. |
| 575 | 17:39
|
Deep convolutional framelet neural network for reference-free EPI ghost correction |
1KAIST, Daejeon, Republic of Korea |
||
Annihilating filter-based low rank Hankel matrix approach (ALOHA) was recently used as a reference-free ghost artifact correction method. Inspired by another discovery that convolutional neural network can be represented by Hankel matrix decomposition, here we propose a deep CNN for reference-free EPI ghost correction. Using real EPI experiments, we demonstrate that the proposed method effectively removes the ghost artifacts with much faster reconstruction time compared to the existing reference-free approaches. |
| 576 | 17:51
|
Scan-specific Robust Artificial-neural-networks for k-space Interpolation (RAKI): Database-free Deep Learning Reconstruction for Fast Imaging |
1Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 3Computer Assisted Clinical Medicine, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany |
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Long scan times remain a limiting factor in MRI. Accelerated imaging is commonly required, with parallel imaging being the most clinically used approach. Recently, machine learning has also been applied to accelerated MRI reconstruction, where the focus has been on training regularizers on large datasets. In this work, we develop a scan-specific deep learning k-space method for reconstruction of undersampled data. The proposed method, Robust Artificial-neural-networks for k-space Interpolation (RAKI) learns a non-linear convolutional neural network from limited autocalibration signal. Phantom, cardiac and brain data show that RAKI improves upon the reconstruction quality of linear k-space interpolation-based parallel imaging methods. |
| 577 | 18:03
|
Application of a Scan-Specific Deep Learning Reconstruction to Multiband/SMS Imaging |
1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2Computer Assisted Clinical Medicine, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany, 3Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States |
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The use of convolutional neural networks (RAKI (Robust Artifical-neural-networks for k-space Interpolation)) trained for a scan specific acquisition is applied to Multiband/Simultaneous MultiSlice aliased k-space. With CNN’s of similar size as the RO-SENSE-GRAPPA kernels, reduced signal aliasing is obtained. |
| N02 | Tuesday 16:15 - 18:15 | Moderators: Priti Balchandani & Pratik Mukherjee |
| 578
|
16:15
|
High-resolution T2*-weighted imaging of subcortical brain enhanced by motion and field compensation |
1Institute for Biomedical Engineering, ETH Zurich & University of Zurich, Zurich, Switzerland |
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We apply field control and prospective motion correction simultaneously to obtain a high-quality and high-resolution (0.3mm x 0.3mm x 1mm) T2* weighted depiction of subcortical brain structure which is a notoriously difficult region for T2* weighted scans at high field due to physiological field fluctuations. The combined approach of field control and motion correction achieved superior imaging results in the studied scenario. |
| 579 | 16:27
|
7T MRI allows detection of disturbed cortical layers in medial temporal lobe in patients with Alzheimer’s disease |
1Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Human Genetics, Leiden University Medical Center, Leiden, Netherlands, 3Anatomy and Neurosciences, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, Netherlands, 4Percuros BV, Leiden, Netherlands |
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Using 7T T2*-w imaging, we scanned post-mortem hemispheres of aged controls and patients with Alzheimer’s disease (AD) to assess the potential of MRI for anatomical cortical parcellation of the medial temporal lobe based on |
| 580
|
16:39
|
GABA concentration in sensorimotor area correlates with observed inhibitory response measured by magnetoencephalography. |
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2School of Psychology, University of Nottingham, Nottingham, United Kingdom |
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Electrophysiological imaging suggests that task induced change in beta oscillations (13-30Hz) modulates with attention, and reflects synaptic inhibitory responses. GABA is known to mediate synaptic inhibition and hence may relate to these electrophysiological dynamics. Here, we determined GABA concentration in primary sensorimotor cortex, using MRS at 7T, and measured the electrophysiological response to a sensory attention task, using MEG, in the same region. We correlated the post-stimulus synchronisation in beta in the left sensory-motor cortex with GABA concentration detected using a STEAM sequence. Results show significant correlation (R = 0.48; p 0.010) across 28 participants. |
| 581 | 16:51
|
Ultra-high resolution MR spectroscopic imaging at 7 Tesla in Multiple Sclerosis: Initial results and comparison with clinical MR imaging |
1High-field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 3Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 4Center for Brain Research, Medical University of Vienna, Vienna, Austria, 5Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 6F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 7Comenius University in Bratislava, Martin, Slovakia, 8Department of Neurology, Medical University of Vienna, Vienna, Austria |
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Conventional T1/T2-weighted MRI has become indispensable for Multiple Sclerosis(MS) diagnosis and treatment monitoring, although it reflects only general macroscopic tissue damage. MRSI allows the additional mapping of pathological processes in MS on a biochemical level. In 39 relapsing-remitting MS patients and an age/sex-matched control group(n=10), we show that clinically feasible ultra-high resolution (100x100 matrix) FID-MRSI in ~6min reveals even well-delineated (sub-)cortical MS lesions down to ~3mm in regions inconspicuous on conventional MRI. Regions of mIns were often larger than on FLAIR and NAA maps, suggesting that mIns increase may be an earlier imaging biomarker for neuroinflammation/lesion development than conventional MRI. |
| 582 | 17:03
|
Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of Alzheimer’s disease: comparison with amyloid plaques detection in human brains. |
1Molecular Imaging Research Center (MIRCen), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Fontenay aux Roses, France, 2INSERM U986, Université Paris-Sud, Fontenay-aux-Roses, France, 3Institut des Maladies Emergentes et des Therapies Innovantes (IMETI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Fontenay aux Roses, France |
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Gadolinium(Gd)-stained MRI is based on Gd-contrast agent administration into the brain. This method significantly improves the detection of amyloid plaques, one of the lesions of Alzheimer's disease and a potential biomarker for its diagnosis. Here, we aimed to better understand the origin of contrast induced by amyloid plaques by determining critical parameters required for their detection using five mouse models of amyloidosis presenting with different plaque typologies. Then, we showed for the first time that Gd-stained MRI can detect amyloid plaques in postmortem human brain tissues and compared the detection achieved in mice with those obtained in human samples. |
| 583 | 17:15
|
$$$^{31}$$$P MRSI of asymptomatic C9orf72 carriers and non-carriers at 7 Tesla |
1Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy, 2Radiology/Centre for Image Sciences, University Medical Centre Utrecht, Utrecht, Netherlands, 3Neurology, Brain Center Rudolf Magnus, University Medical Centre Utrecht, Utrecht, Netherlands |
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Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease with a largely unknown pathogenesis. The most common gene mutation in both familial and sporadic ALS is the C9orf72 repeat expansion. Investigating asymptomatic carriers of this mutation might give more insight into possible preclinical brain alterations. Using whole brain 31P MRSI at 7T, glycerophosphoethanolamine-to-phosphocreatine ratio (GPE/PCr) and uridine diphosphoglucose-to-phosphocreatine ratio (UDPG/PCr) were found to be higher in a number of brain regions in asymptomatic carriers compared with asymptomatic non-carriers. The increased GPE/PCr and UDPG/PCR might respectively indicate an increased catabolism of the cell membranes and an imbalance of energy metabolism. |
| 584 | 17:27
|
Interpreting fast and slow 23Na relaxation rates in human brain: comparisons with tissue microstructure at 7 Tesla. |
1University of Melbourne, Melbourne, Australia |
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23Na, a quadrupolar nucleus, exhibits bi-exponential relaxation in brain tissue. This study aimed to compare fast and slow sodium T2* relaxation times obtained using a 3D multi-echo radial sequence, to measures of tissue microstructure derived from advanced diffusion MRI and proton T1 mapping at 7T. We observed significant correlations between sodium T2* relaxation times and all measures of fibre and cellular density and T1. The results suggest that relative contribution of quadrupolar and dipolar relaxation pathways are related to the underlying tissue microstructure. |
| 585 | 17:39
|
Whole Brain FLAIR Imaging at 7T Employing Universal Pulses |
1German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 2NeuroSpin, CEA, Saclay, France, 3Department of Physics and Astronomy, University of Bonn, Bonn, Germany |
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In this work, we present a fluid suppressed Turbo-Spin-Echo sequence for ultra-high-field application. To obtain images comparable in contrast and homogeneity with 3T results, we replaced all RF pulses with universal parallel transmit kT-point pulses. During the imaging session, no pulse calculations or complex B1 shimming procedures are necessary, making this approach a promising tool for clinical application. |
| 586
|
17:51
|
Parallel transmission kT-points and CAIPIRIHNA accelerated MP2RAGE for ultra-high field anatomical imaging |
1Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands, 2MBIC - Maastricht Brain Imaging Center, Maastricht University, Maastricht, Netherlands, 3Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 4Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 5Department of Radiology, University Hospital of Lausanne, Lausanne, Switzerland, 6LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland |
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The MP2RAGE imaging sequence is widely used for T1 weighted anatomical imaging, especially at 7T, where B1 inhomogeneity may degrade the image quality. This study demonstrates an improved MP2RAGE sequence featuring kT-points parallel transmission excitation and CAIPIRINHA 2D acceleration for improved T1 weighted anatomical images of the living human brain at 7 T and 9.4 T. High resolution (0.6 mm and 0.45 mm isotropic) data with high contrast-to-noise ratio allow for improved cortical segmentation, e.g. for cortical laminar investigations. We further demonstrate a 6-fold accelerated whole brain CAIPIRINHA acquisition at 0.6 mm resolution in only 4:10 min. |
| 587
|
18:03
|
Compartmental brain sodium concentrations in human brain tissues in white matter and grey matter: a multi-echo ultra-high field 23Na-MRI study |
1CRMBM, Aix-Marseille University, Marseille, France, 2CEMEREM, APHM Hôpitaux de la Timone, Marseille, France, 3Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 4German Cancer Research Centre, Division of Medical Physics in Radiology, Heidelberg, Germany |
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Using multi-echo 23Na-MRI at 7T acquired in 13 healthy subjects and modelling the relationship between signal and reference concentration and applying it to in vivo 23Na-MRI signal, we quantify both T2* decay times and concentrations associated with short and long components for the first time. Relaxation times and concentrations differed between grey and white matter and subregions of differing tissues, suggesting sensitivity of 23Na toward features of tissue composition. As such, these results raise the prospect of multi-echo 23Na-MRI as an adjunct source of information on biochemical mechanisms in both physiological and pathophysiological states. |
| N03 | Tuesday 16:15 - 18:15 | Moderators: Moriah Thomason & Tomoki Arichi |
| 588
|
16:15
|
Short-range functional connections at birth predict neurodevelopmental outcome at 2 years of age |
1Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 2Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States |
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Short-range functional connectivity (FC) is the major contributor to overall significant FC increases around birth. With |
| 589 | 16:27
|
“Multi-Layer Connectome” for Robust Multi-Subject Brain Network Analysis and its Application to Baby Connectome Development Study |
1University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea |
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We propose a multi-layer connectome analysis method that extends the existing majority of single-layer brain network studies. In this method, multiple subjects’ connectome constitutes a multi-layer hyper-network with hyper-edges across layers. Result from applying this method to delineating neonatal brain development indicates that our method can capture robust group-level modules while keeping meaningful individual variability. The “increasing functional segregation/integration” model is further refined by us with a “consistent large-scale functional segregation/integration” with “rewiring-induced module refinement”, as well as an invert-U-shaped subject variability in modular structure in the first two years of life. |
| 590 | 16:39
|
Resting-state functional connectivity alterations in adolescents with fetal alcohol spectrum disorders |
1MRC/UCT Medical Imaging Research Unit, Division of Biomedical Engineering, University of Cape Town, Cape Town, South Africa, 2Department of Human Biology, University of Cape Town, Cape Town, South Africa, 3Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States, 4Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa |
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In a study of children with fetal alcohol spectrum disorders (FASD) and community controls assessed at age 11 years, alcohol-exposed children showed |
| 591 | 16:51
|
Early Development of Modular Organization in Brain Functional Networks at Multiple Scales |
1Sun Yat-Sen University, Guangzhou, China, 2University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 3South China University of Technology, Guangzhou, China |
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Increasing studies focus on delineating the development of brain networks of infants by detecting the corresponding modular organization. However, in these papers, the adopted module detection method, i.e., maximizing modularity, has a resolution limit, such that modular structures could only be investigated at a particular scale. To address this issue, by leveraging a novel multi-resolution modularity detection method, we explored the development of |
| 592 | 17:03
|
Integrated structural and functional connectivity analysis to characterize abnormalities in ADHD |
1Brigham and Women's Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Boston Children's Hospital, Boston, MA, United States |
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We introduce a novel approach for integrating novel diffusion MRI (dMRI) derived microstructural properties and resting state functional MRI (rsfMRI) derived functional measures to obtain a comprehensive understanding of brain abnormalities in neuropsychiatric disorders. We applied this methodology to study abnormalities in children with attention-deficit hyperactivity disorder (ADHD), providing a probabilistic view of the abnormal connections, thus accounting for the heterogeneity in the presentation of ADHD. We further show that the integrated analysis is significantly more sensitive than separate dMRI and rsfMRI analyses. Apart from known connections reported to be abnormal in the literature, we find several new abnormal connections in ADHD subjects with high probability. |
| 593 | 17:15
|
Finding the baby in the bath water – evidence for task-specific changes in resting state functional connectivity evoked by training |
1National Institute of Mental Health, Bethesda, MD, United States |
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Resting-state fMRI (rsFMRI) has been used for studying training-related changes in brain function during the offline period of skill learning. However, the lack of experimental control during “rest” makes it difficult to separate the impact of training from technical artifacts and experimental confounds like time-of-day (TOD) related changes in MRI signal. Here, by using multiple tasks (rest, visuo-spatial training, motor sequence training), we mapped out the spatial topography of changes in rsFC evoked by TOD and by training. Our findings suggest that task-specific changes in rsFC due to visuo-spatial and motor-sequence learning are dissociable from changes due to TOD. |
| 594 | 17:27
|
A connectome-wide investigation of the longitudinal effect of real-time fMRI amygdala neurofeedback emotional training on resting-state connectivity in combat veterans with PTSD |
1Laureate Institute for Brain Research, Tulsa, OK, United States, 2Laureate Psychiatric Clinic and Hospital, Tulsa, OK, United States, 3George Mason University, Fairfax, VA, United States, 4University of Arkansas, Fayetteville, AR, United States, 5University of Oklahoma, Norman, OK, United States |
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We introduced a longitudinal Multivariate Distance Matrix Regression (LMDMR) analysis for a connectome-wide study of the longitudinal effect on resting-state fMRI functional connectivity (rsfMRI-fc) without a priori seed definition. We applied this analysis to investigate the effect of real-time fMRI amygdala neurofeedback training in combat veterans with PTSD. The analysis revealed a significant interaction between a decrease in hyperarousal symptom and an increase in rsfMRI-fc between the precuneus and the left superior frontal region. This result suggests that enhanced regulation of emotional memory retrieval helped reduce PTSD symptoms. |
| 595
|
17:39
|
Intra-operative acquisition of sensorimotor fMRI during glioma resection: evaluation of feasibility and clinical applicability. |
1Neuroradiological Academic Unit, UCL Institute of Neurology, London, United Kingdom, 2Psychology and Language Sciences, Birkbeck-UCL Centre for Neuroimaging, London, United Kingdom, 3Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 4Medical Physics and Biomedical Engineering, University College London Hospital, London, United Kingdom, 5Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom, 6Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 7Department of Neuroanaesthesia, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 8Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany |
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Intra-operative fMRI has the potential to improve neurosurgical outcomes and we have previously shown that the task-related BOLD signal can be acquired under general anaesthesia. Our next goal was to acquire fMRI intra-operatively with the skull open.
In 12 patients, we performed 24 acquisitions of a passive sensorimotor paradigm during the resection of their brain tumour. The fMRI data were evaluated by neuroradiologists, assessing its applicability for the provision of a clinical report on the location of sensorimotor activation to the neurosurgeon. 17/24 acquisitions were scored as useful.
We conclude that intra-operative fMRI is feasible and produces clinically useful data. |
| 596 | 17:51
|
Real-Time Resting-state fMRI for Presurgical Mapping in Patients with Brain Tumors |
1Neurology, Physics and Astronomy, University of New Mexico, Albuquerque, NM, United States, 2Neurosurgery, University of New Mexico, Albuquerque, NM, United States, 3Neurology, University of New Mexico, Albuquerque, NM, United States |
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We investigated the feasibility of presurgical mapping in patients with brain tumors using real-time rsfMRI analysis methodology in combination with high-speed multi-band EPI. The objective was to map sensorimotor and language resting state networks in the vicinity of brain tumors and to monitor data quality online. We validated this approach in comparison with tfMRI and intra-operative electrocorticography (ECog). The data in patients show a high degree of consistency between resting state connectivity, task-based activation and ECS localization of motor cortex and Broca’s area. Localization of Wernicke’s area was more variable, both in rsfMRI and tfMRI. |
| 597 | 18:03
|
Association between Tremor Severity Improvement and Functional Connectivity Changes after Magnetic Resonance Guided Focused Ultrasonic Thalamotomy Treatment in Essential Tremor Patients |
1Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland Baltimore, Baltimore, MD, United States, 2Department of Neurosurgery, University of Maryland Baltimore, Baltimore, MD, United States, 3Department of Neurology, University of Maryland Baltimore, Baltimore, MD, United States |
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Essential tremor (ET) is the most common movement disorder and often characterized by a slowly progressive involuntary posture and/or kinetic tremor, usually affecting both upper extremities. Ablation of the ventral intermediate nucleus (VIM) of the thalamus with MRgFUS is an effective and FDA-approved treatment for medication refractory ET patients. However, very little is known regarding brain functional changes before and after the treatment and even less about its association with the tremor severity changes after treatment. This study aimed at investigating the longitudinal tremor improvement and its association with the changes of Functional connectivity of left VIM at 1-year post-treatment. |
| S04 | Tuesday 16:15 - 18:15 | Moderators: Rob Tijssen & Graham Wright |
| 598
|
16:15
|
Real-time acquisition, reconstruction, and mixed-reality display system for 2D and 3D cardiac MRI |
1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Department of Radiology, School of Medicine, Case Western Reserve University, Cleveland, OH, United States |
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Cardiac images suitable for 3D visualization are acquired, reconstructed, and displayed in real-time using the Microsoft HoloLens. This system could be used for guiding cardiac (or other) interventions, or be used to view time-resolved 2D or 3D datasets to facilitate the visualization of anatomical changes through time. |
| 599 | 16:27
|
Initial results for MRI-guided catheterization in children and young adults with congenital heart disease using the partial saturation (pSAT) sequence |
1Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 2Paediatric Cardiology, Queen Elizabeth University Hospital, Glasgow, United Kingdom, 3Division of Imaging and Biomedical Engineering, King's College London, London, United Kingdom, 4King's College London, London, United Kingdom, 5Philips, Hamburg, Germany, 6Physikalisch-Technische Bundesanstalt, Berlin, Germany, 7Philips Research Laboratories, Hamburg, Germany, 8UT Southwestern Medical Center, Dallas, TX, United States |
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CMR is a promising alternative to x-ray fluoroscopy for the guidance of cardiac catheterization procedures. We have recently developed a partial saturation (pSAT) sequence which enables passive tracking of balloon-wedge catheters with positive contrast, using a dilution containing gadolinium. 23 patients from 2 different centres were recruited. MRI-guidance was performed using the pSAT sequence applied in the iSuite platform® or an interactive imaging mode. During real-time MRI catheterization the balloon was visualized during 64±19% of the scanning time. pSAT angle was 30-50° in all patients. Mean subjective image quality scores were 3.7 out of 5 for heart visualisation and 4.6/5 for balloon/blood contrast. |
| 600 | 16:39
|
MRI-guided right heart catheterization using a commercial nitinol guidewire: Experience in 6 patients |
1National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States |
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We have performed MRI-guided right heart catheterization in patients with a commercial nitinol guidewire for the first time. MRI-guided cardiovascular interventions have been limited by the unavailability of an guidewire that is safe and visible. Here, we use real-time spiral gradient echo imaging to reduce RF-induced heating on a commercial nitinol 150cm Glidewire. The Glidewire was found to generate <0.2°C in the ASTM-2182 phantom in all configurations. With IRB approval, the guidewire catheterization was performed on six patients. Blood biomarkers remained normal and the reported clinical benefits were increased shaft conspicuity, increased shaft stiffness, and ability to track to chambers. |
| 601 | 16:51
|
Fully MR-Guided Implantation of a Bioresorbable Scaffold in the Left Coronary Artery of a Pig at 3T |
1Dept. of Radiology, Medical Physics, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 2Dept. of Cardiology and Angiology I, University Heart Center, Freiburg, Germany, 3MaRVis Interventional GmbH, Frechen, Germany |
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MR-guided cardiovascular interventions do not use ionizing radiation, provide excellent soft tissue contrast, and enable functional measurements. The feasibility of MR-guided percutaneous coronary intervention has been demonstrated in animal trials using metallic stents. Recently, bio-resorbable vascular scaffolds have been introduced for stenting of coronary arteries. These scaffolds enable artifact-free MR imaging of the coronary artery segment that the result of the intervention can be readily assessed via MR imaging. We show the first fully MR-guided PCI with a bioresorbable scaffold in the LCA of a pig at 3T using dedicated active guiding catheters, an MR-safe guidewire and BVS delivery system. |
| 602 | 17:03
|
Assessing MR-guided catheter contact with the myocardium using device motion: A feasibility study |
1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Sunnybrook Research Institute, Toronto, ON, Canada |
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Assessing contact of the catheter tip with the endocardial wall remains challenging during MR-guided electroanatomic voltage mapping (EAVM) of the heart. In this study we investigated whether the synchronicity of catheter motion with the beating heart can serve as an indicator of catheter-endocardium contact. The results from this study show that that synchronicity could potentially provide an indirect measure of endocardial contact and could serve a metric by which quality of EAVM data can be evaluated. |
| 603
|
17:15
|
Real-time MRI endoscopy at up to 10 frames/sec |
1Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, United States, 2Russell H. Morgan Dept. of Radiology, Johns Hopkins University, Baltimore, MD, United States, 3Biomedizinishe NMR Forschungs GmbH, Max-Plank-Institut fur biophysikalische Chemie, Gottingen, Germany |
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Mininally-invasive intravascular MRI at 3T and above is capable of providing high resolution imaging from within blood vessels and identifying atherosclerosis using miniaturized detectors ~2mm in diameter. Endoscopic MRI is a technique that employs the miniature probe itself to localize the MRI signal to a sensitive disk, and provide images from the view-point of the probe itself. At 3T, acquisition speed has been limited to 2 frames/sec at 300μm resolution, which although fast, is not truly real-time. Here we report a truly real-time MRI endoscope with fully integrated real-time continuous MRI visualization at up to 10 frames/sec. |
| 604 | 17:27
|
Real-time MR Brain Infusion Monitoring Enables Accurate Prediction of End Drug Distribution |
1Therataxis, LLC, Baltimore, MD, United States, 2TherVoyant, Madison, WI, United States, 3Medical Physics, Madison, Madison, WI, United States, 4Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 5Psychiatry, University of Wisconsin - Madison, Madison, WI, United States, 6Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, 7Radiology, University of Wisconsin- Madison, Madison, WI, United States |
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The hetergeneity of the brain makes designing a desired end drug distribution through pressurized catheters difficult. We present a method to utilize real-time MR monitoring of a co-infused Gd tracer during initial stages of the infusion to derive a real-time 3D estimate of the velocity front. We demonstrate considerable improvement in predicting the actual drug distribution using the MR real-time data in four cases using a large animal surgical model. |
| 605 | 17:39
|
Real-time MRI-guided endovascular model of cerebral ischemia in swine |
1Department of Neurology and Neurosurgery, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland, 2Central Clinical Hospital of Ministry of the Interior and Administration in Warsaw, Warsaw, Poland, 3Department of Surgery and Roentgenology with the Clinic, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland, 4Department of Gamete and Embryo Biology, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland, 5NeuroRepair Department, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland, 6Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 7Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States |
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Animal models of stroke are essential for developing therapies. Rodent models of stroke are widely used but they lack clinical relevance. Endovascular models in large animals are most desired, but till now they were available in expensive and hard-to-access dogs and primates. Swine is preferred model but till now stroke modeling was through surgical craniotomy, a highly invasive procedure inflicting unrelated morbidity. Endovascular modeling was not possible due to vascular rete preventing catheter access to cerebral vessels. We circumvented this obstacle by intra-arterially injecting SPIO-labeled pro-coagulant thrombin under real-time MRI, which was instrumental to fine-tune injection to occlude cerebral arteries. |
| 606 | 17:51
|
PET-MRI Quantification of 89Zr-Iron Oxide Nanoparticles for Targeted Magnetic Drug Therapy |
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Bioengineering, University of California, Berkeley, Berkeley, CA, United States |
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One recent application of magnetic nanoparticles is to deploy an endovascular magnetic device to selectively remove magnetically-linked chemotherapy during an intra-arterial treatment procedure. In order to measure the device’s efficacy, 89Zr-iron oxide nanoparticles could be imaged using PET-MR. We measured quantitative susceptibility values (Δχ), R2*, and 89Zr-PET uptake of increasing concentrations of 89Zr-IONP in vitro, and in liver in vivo by acquiring a multi-echo UTE GRE sequence and time-of-flight PET. Phantom evaluations demonstrated linear correlation between Δχ, R2*, and 89Zr-IONP uptake. In vivo, substantial increase was observed after 89Zr-IONP infusion. This approach shows promise tracking the biodistribution of radiolabelled magnetic nanoparticles. |
| 607
|
18:03
|
Perceptual Accuracy of a Mixed-Reality System for MR-Guided Breast Surgical Planning in the Operating Room |
1Radiology, Stanford University, Stanford, CA, United States, 2Bioengineering, Stanford University, Stanford, CA, United States, 3Mechanical Engineering, Stanford University, Stanford, CA, United States, 4Surgery, Stanford University, Stanford, CA, United States, 5Electrical Engineering, Stanford University, Stanford, CA, United States |
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One quarter of women who undergo lumpectomy to treat early-stage breast cancer in the United States undergo repeat surgery due to concerns that residual tumor was left behind. We have developed a supine breast MRI protocol and a system that projects a 3D “hologram” of the MR data onto a patient using the Microsoft HoloLens. The goal is to reduce the number of repeated surgeries by improving surgeons’ ability to determine tumor extent. We are conducting a pilot study in patients with palpable tumors that tests a surgeon’s ability to accurately identify tumor location via mixed-reality visualization during surgical planning. |
| S06 | Tuesday 16:15 - 18:15 | Moderators: Takeshi Yokoo & Mi-Suk Park |
| 608 | 16:15
|
Dietary intervention can induce changes in hepatic fat content during the day detectable by MR spectroscopy |
1MR-Unit, Dept. Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic |
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We analyzed in vivo hepatic fat content changes during the day under different dietary interventions (fasting, fat alone, fat + fructose, fat + glucose, and glucose alone). Single voxel 1H MR spectroscopy of the liver in ten healthy volunteers was used at 3T MR system. We demonstrated that it is possible to induce the hepatic fat content changes by appropriately chosen dietary interventions and that such changes can be detected noninvasively by 1H MR spectroscopy. |
| 609 | 16:27
|
Dynamics of adipose tissue and liver fat: Effects of acute exercise |
1German Diabetes Center Düsseldorf, Düsseldorf, Germany |
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Impaired adipose tissue fat uptake may lead to liver fat accumulation. Acute exercise releases adipose tissue fat, which also increases liver fat. Here we examine how a single bout of HIIT exercise affects the dynamics of adipose tissue and liver fat by MRS and an insulin clamp. Subjecting participants to a single bout of HIIT resulted in an improved response to insulin in both adipose tissue and liver. These results suggest that adipose tissue sequesters harmful saturated fats that otherwise would accumulate in the liver and that exercise improves the uptake of these fats thereby leading to long-term health effects. |
| 610 | 16:39
|
A Novel Analysis Strategy for Assessing Liver Lipid Composition with Magnetic Resonance Spectroscopy |
1Radiology, University of Minnesota, Minneapolis, MN, United States, 2Pediatrics, University of Minnesota, Minneapolis, MN, United States |
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Measuring lipid composition (e.g., saturation levels) with MRS requires analysis of small lipid resonances in addition to the 1.3 ppm methylene peak. This is straightforward in adipose tissue but difficult in the liver due to lower concentration and greater spectral linewidths. In this work we propose a new fitting method that models the full lipid spectrum from 3 parameters and fits a multi-TE array of spectra simultaneously. This approach produces repeatable and physically reasonable estimations of liver fat composition in a wide range of fat factions. |
| 611 | 16:51
|
Gd-EOB-DTPA-enhanced T1ρ Imaging vs. Diffusion Metrics for Assessment Liver Inflammation and Early Stage Fibrosis of Nonalcoholic Steatohepatitis in Rabbits |
1Radiology, Southern Medical University, Guangzhou, China, 2Radiology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 3Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 4Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 5Philips Healthcare, Beijing, China, 6Southern Medical University, Guangzhou, China |
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This study is to evaluate applications of T1ρ, T1ρ on hepatobiliary phase (HBP, with Gd-EOB-DTPA enhancement) and IVIM in assessing of early-stage NASH in rabbits model. Results show that T1ρ (HBP) after Gd-EOB-DTPA administration is a more sensitive method for assessment of NAFLD activity, while a combination of T1ρ(HBP) and IVIM showed highest diagnostic value. |
| 612 | 17:03
|
Assessment of Portal Hypertension with Multi-parametric Hepatic MR Elastography in Mouse Models |
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States |
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We used multi-parametric hepatic MR Elastography (MRE) in two different mouse models with congestion and cirrhosis-induced portal hypertension, respectively. Spearman correlation was used to analyze the relationships between the MRE-assessed liver stiffness, damping ratio, volumetric strain, stiffness frequency dispersion, and the portal pressure directly measuared in vivo. We found that volumetric strain and damping ratio had negative correlations (ρ=-0.7515, ρ=-0.5528 respectively), while shear stiffness had a positive correlation (ρ=0.6983) with portal pressure. Additionally, damping ratio changes differently in portal hypertension induced by congestion and cirrhosis. In summary, multi-parametric MRE has potential to differentiate and quantify congestion and cirrhosis-induced portal hypertension. |
| 613 | 17:15
|
Staging of rat liver fibrosis using monoexponential, stretched exponential and diffusion kurtosis models with diffusion weighted imaging- magnetic resonance |
1Department of Radiology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China, 2Zhujiang Hospital, Southern Medical University, Guangzhou, China, 3The First Affiliated Hospital of Jinan University, Guangzhou, China, 4MR Clinical Science, Philips Healthcare, Guangzhou, China |
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Non-Gaussian DWI in Various Stages of Liver Fibrosis |
| 614 | 17:27
|
Observed MRI changes following Directly-Acting Antiviral Therapy in Hepatitis-C virus patients |
1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 2NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom |
||
Hepatitis C Virus (HCV) is globally the largest viral cause of mortality. Directly Acting Antiviral (DAA) therapy achieves >90% sustained virological response in HCV patients. We used multiparametric MRI to assess changes in hepatic angio-architecture after patients had DAA therapy. The time window between pre- and post-treatment scans was of 3-6 months. We observed changes in hepatic microstructure indicated by a reduction in liver T1 (35±4ms), T2 (2.5±0.8ms) and T2* (3.0±0.7ms) which we suggest are linked to reduced pro-inflammatory milieu, including interstitial oedema, within the liver. No changes were observed in hepatic/splanchnic blood flow or perfusion. |
| 615 | 17:39
|
Quantitative Characterization of the Motion Sensitivity of Stimulated Echo Diffusion-weighted Imaging in the Liver |
1Medical Physics, University of Wisconsin Madison, Madison, WI, United States, 2Radiology, University of Wisconsin Madison, Madison, WI, United States, 3Global MR Applications & Workflow, GE Healthcare, Madison, WI, United States |
||
STimulated Echo (STE) DWI is able to provide high b values with moderate echo times by increasing the mixing time (TM). However, long TM in STE-DWI also lead to increased sensitivity to bulk motion. To understand the tradeoff between SNR and motion sensitivity of STE DWI, this study assessed the quantitative relationship between TE, TM, and motion |
| 616 | 17:51
|
Golden Angle Radial Reconstruction Using Partial Separability for High Spatiotemporal Resolution Liver Dynamic Contrast-Enhanced Imaging |
1Center for Biomedical Imaging Research, Tsinghua University, Beijing, China |
||
Dynamic Contrast-Enhanced imaging is an important tool in diagnosing hepatic diseases. Improving spatiotemporal resolution is of great significance for clinical purpose. In this work we introduce the partial separability constraint to the reconstruction of stack-of-stars golden angle radial data. Both in-vivo and stimulated liver experiment were conducted and the proposed method (PS+S) showed better reconstruction quality compared to the existing methods without partial separability constraint. |
| 617
|
18:03
|
Improving Variable-Density Single-Shot Fast Spin Echo with Deep-Learning Reconstruction Using Variational Networks |
1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Global MR Applications and Workflow, GE Healthcare, Menlo Park, CA, United States, 3GE Global Research Centre, GE Healthcare, Herzliya, Israel, 4Radiology, Stanford University, Stanford, CA, United States, 5GE Global Research Centre, GE Healthcare, Niskayuna, NY, United States |
||
In this work, a deep-learning-based reconstruction approach using a variational network (VN) was developed to accelerate the variable density single-shot fast spin echo (VD SSFSE) reconstruction. The image quality of this approach was clinically evaluated compared to standard parallel imaging and compressed sensing (PICS). The VN approach achieves improved image quality with higher perceived signal-to-noise ratio and sharpness. It also allows real-time image reconstruction of VD SSFSE sequences for practical clinical deployment. |
| W03/04 | Tuesday 16:15 - 18:15 | Moderators: Anke Henning & Christopher Rodgers |
| 618 | 16:15
|
Towards Full-Brain FID-MRSI At 7T With 3D Concentric Circle Readout Trajectories |
1High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States, 3Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 4The Johns Hopkins University School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD, United States, 5Kennedy Krieger Institute, F. M. Kirby Research Center for Functional Brain Imaging, Baltimore, MD, United States |
||
Proton magnetic resonance spectroscopic imaging is a powerful technique for clinical diagnosis; however, low spatial resolutions together with long scan times and SNR-per-time inefficiency prevent its wide spread application. The already proposed 2D-CONCEPT (concentric circle echo planar trajectories) sequence overcomes this issue by capitalizing most efficiently on the hardware constraints of the gradient system. The purpose of this abstract is to present first preliminary results of an extension to 3D-CONCEPT for full-brain 3D-FID-MRSI at 7T for a 64x64x31 matrix acquired within 23 minutes. |
| 619
|
16:27
|
Whole Brain High Resolution Metabolite Mapping Using 1H FID MRSI with Slice-wise B0 Shim Updating at 9.4T |
1Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2IMPRS for Cognitive and Systems Neuroscience, Eberhard-Karls University of Tuebingen, Tuebingen, Germany, 3Institute of Physics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany |
||
In this work, we present high resolution whole-brain metabolite maps acquired at 9.4T for the first time. By combining a robust acceleration method with dynamic B0 slice-wise shim updating, we achieved high quality metabolite maps from 10 slices of the brain with a nominal voxel size of ~80μL in ~25 minutes. |
| 620 | 16:39
|
Prospective motion and B0 shim correction for MRS at 7 Tesla |
1University of Minnesota, Minneapolis, MN, United States |
||
The goal of this study was to demonstrate the feasibility of prospective motion and shim correction for MRS at 7 Tesla. We combined an optical tracking system for motion correction and a shim navigator for first-order B0 shim correction into a semi-LASER sequence. The new sequence was validated in the prefrontal cortex, a region sensitive to motion due to susceptibility effects induced by the proximity of the nasal cavity. Results show excellent performance, with similar spectral quality (signal-to-noise ratio and linewidth) before, during, and after motion when both motion and shim navigators are used. |
| 621
|
16:51
|
Reproducibility of cardiac 31P MRS at 7 T |
1OCMR, RDM Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, 2Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, 3Wellcome Centre for Intergrative Neuroimaging, University of Oxford, Oxford, United Kingdom, 4Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom |
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Cardiac PCr/ATP ratios measured by 31P MRS change in cardiovascular disease giving them value as a biomarker. We scanned 13 healthy volunteers at 7T, assessing their PCr/ATP with 6 ½ min 31P CSI scans. These data have better reproducibility than a 30min 3T protocol previously published by our centre. Repeated PCr/ATP measurements from subjects in this study were not significantly (P=0.83) different. Measurements were significantly different (P<0.001) from DCM patient data acquired in a previous 7T study using the same coil and pulse sequence. This data will allow us to plan future 7T 31P-MRS clinical studies. |
| 622 | 17:03
|
Creatine Kinase Rate Constant in the Human Heart at 7T: A Novel Superfast Magnetization Saturation Transfer Method |
1Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States, 2Department of Biomedical Engineering, University of Alabama Birmingham, Birmingham, AL, United States, 3Siemens Healthineers and AUMRI Center, Auburn, AL, United States, 4Auburn University, Auburn, AL, United States |
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Changes in Creatine Kinase (CK) system are observed in heart failure and measurement of CK reaction rate constant (kf) can be useful to monitor pathology. 7T MR scanner offers improved signal to noise and spectral resolution and has potential for robust measurements. In this study we demonstrate novel superfast saturation transfer method (T1nom – method) to measure ATP production rate via CK forward reaction in human hearts at 7T. Spatial localization was achieved by GOIA-1D-ISIS/2D-CSI approach. Our measured kf values were consistent with literature. |
| 623 | 17:15
|
Large FOV phosphor MR Spectroscopic imaging with multi-transmit proton MR imaging in the liver at 7 Tesla |
1University Medical Center Utrecht, Utrecht, Netherlands, 2University of Oxford Centre for Clinical Magnetic Resonance Research (OCMR), Oxford, United Kingdom |
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We combined 1H MRI and 31P MRSI in the liver by integrating a 31P RF body coil in a 7T MR system with a 16 channel 31P receive array merged with 1H fractionated dipole antennas The setup facilitates uniform 31P excitation by the body coil with high sensitivity from the receiver array, while providing B1 shimmed proton imaging with a dipole array. |
| 624
|
17:27
|
Dynamic perfusion and T2*-weighted 1H MRI interleaved with multivoxel 31P MRS of exercising human calf at 7T |
1Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, 2MR Center of Excellence, Medical University of Vienna, Vienna, Austria, 3Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, 4Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 5NMR laboratory, Institute of Myology, Paris, France |
||
To quantify perfusion and high-energy metabolite time courses of exercising gastrocnemius and soleus muscles in one time-resolved acquisition, 1H arterial spin labeling with multislice EPI was interleaved with multivoxel semi-LASER 31P-MRS. Perfusion mapping and T2* weighted MRI yielded reasonable time courses and were less sensitive to motion, compared to single slice acquisitions. Spectroscopic time courses of phosphocreatine, inorganic phosphate and pH with fitted PCr recovery time constants were consistent with literature in both GM and SOL. A significant 31P SNR increase was found when the VOI perceived adiabatic 1H inversion which can be explained by NOE. |
| 625
|
17:39
|
Metabolic Rate of Oxygen Consumption in Brain Tumors: A Pilot 17O-MRI Study |
1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 3Division of Radiology, German Cancer Research Center (DKFZ), Heidelverg, Germany |
||
The cerebral metabolic rate of oxygen (CMRO2) is an interesting biomarker and can be used as a diagnostic parameter in various neurodegenerative diseases or tumors. A dynamic 17O MRI inhalation method was optimized for application in a clinical setting and employed in two patient examinations to investigate CMRO2 in human brain tumors as part of an ongoing pilot study. In tumor tissue, a decrease in oxygen consumption was detected, which is in consistent with the Warburg effect. To our knowledge, the presented work includes the first patient study with dynamic 17O MRI. |
| 626 | 17:51
|
In vivo investigation of lithium brain distribution in bipolar patients using 7Li MRI |
1NeuroSpin, CEA, Gif-sur-Yvette, France, 2Hôpital Fernand Widal, Paris, France, 3Hôpital Albert Chenevrier, Créteil, France, 4Siemens Healthineers, Saint-Denis, France, 5Neurology, RWTH Aachen University Hospital, Aachen, Germany, 6INSERM UMRS-1144, Paris, France |
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As an effective but poorly understood treatment for the prevalent bipolar disorder, studies focused on investigating the cerebral distribution of lithium are of important clinical interest. Here, we report our preliminary results obtained from 5 euthymic bipolar patients using 7Li MRI at 7T. Using a 3D SSFP sequence with ultra-short TE and Twisted Projection Imaging k-space sampling, we can confirm the heterogeneity of lithium brain distribution, as demonstrated by the individual and average concentration values in seven large regions-of-interest. |
| 627 | 18:03
|
Dynamic 23Na-Imaging of the Human Lung with Fully Flexible Intrinsic Respiratory Gating |
1Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 3Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany |
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23Na lung MRI is a potential tool e.g. for investigating tumor viability and treatment response. The acquired data is, however, influenced by respiratory motion since breath-hold acquisitions are not possible due to the long measurement times. Here, we present a method for full flexibility in retrospective gating of 3D-radial data, combined with a Compressed-Sensing reconstruction. Up to 14 frames could be reconstructed from one in-vivo dataset, corresponding to a temporal resolution of 0.27 s. The temporal resolution of 23Na lung MRI could potentially lead to a more accurate quantification of the Tissue Sodium Concentration in the human torso. |
| W05/06 | Tuesday 16:15 - 18:15 | Moderators: Natarajan Raghunand |
| 628 | 16:15
|
Radiated Brain Microenvironment Enhances Glioma Growth and Blunts Immunotherapy |
1Washington University in St. Louis, Saint Louis, MO, United States |
||
Glioblastoma (GBM) is a highly aggressive, malignant, primary brain tumor. Despite state-of-the-art standard-of-care treatment (surgery, chemotherapy, radiation), GBM inevitably recurs, usually in the peritumoral irradiated tumor/brain interface within two centimeters of the margins of the resection cavity. Anti-PD-L1 (immune checkpoint) inhibitors represent an important new class of cancer treatments, but have shown little efficacy in GBM. In a mouse glioma model, we demonstrate that late evolving effects of radiation blunt the therapeutic effectiveness of anti-PD-L1. Carbogen/O2 gas challenge experiments in these mice six weeks post-irradiation demonstrate that the brain microenvironment is physiologically modified, consistent with the observed blunting of immunotherapy. |
| 629 | 16:27
|
Collagen is a major determinant of the viscoelastic properties of stromal-dense tumours: insights from pre-clinical MRE |
1Division of Radiotherapy & Imaging, The Institute of Cancer Research, London, United Kingdom, 2Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom, 3Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London, United Kingdom |
||
The relationship of magnetic resonance elastography-derived viscoelasticity quantified in vivo in nine pre-clinical tumour models exhibiting varying degrees of stromal density was compared with histological assessments of cellularity, collagen and vessel density. Both cellularity and collagen deposition were identified as important determinants of the relative tumour stiffness. |
| 630 | 16:39
|
Pre-existing inflammation in the brain promotes metastases invasion |
1Université de Sherbrooke, Sherbrooke, QC, Canada |
||
We studied the effect of pre-existing inflammation on the genesis of brain metastases using MRI. Molecular MRI enhanced with VCAM-1 targeted microparticles of iron oxide enable the assessment of pre-existing vascular inflammation and then of metastasis implantation. The occurrence of brain metastases was increased by 2 fold when inflammation was present; this could be blocked with VCAM-1 antibody. This underlies the key role of VCAM-1 in tumor seeding to the brain, and suggests that preventive inflammation targeted treatment in cancer patients may minimize risks of brain metastasis. |
| 631 | 16:51
|
Imaging the Interplay of Tumor Vascularity, Hypoxia, pHe, and Lactate |
1Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea, 3Sylverster Comprehensive Cancer Center, Miller School of Medicine University of Miami, Miami, FL, United States |
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We characterized tumor vascularity, extracellular pH (pHe), and tumor lactate in various tumor models, focusing on prostate cancer. Spatial mapping demonstrated that vascular blood flow and permeability varied significantly in well-vascularized regions across tumor models and that the fraction of tumor necrosis was higher in the human than the murine models. The spatially most heterogeneous tumor type was characterized by the lowest lactate, a pHe of ~7.1 in well-vascularized regions, with lower pHe in less vascularized regions, and increasing lactate with decreasing vascular blood flow and permeability. |
| 632
|
17:03
|
Assessing Tumor Hypoxia Based on Hypoxic Gas Breathing |
1Radiology, UT Southwestern Medical Center, Dallas, TX, United States |
||
Tumor response to hypoxic gas breathing challenge was explored using oxygen-sensitive MRI in rat 13762NF breast tumors and compared with the more conventional hyperoxic gas breathing challenge. In viable tumor regions, blood oxygenation decreased with 16% O2 breathing (demonstrated by an increase in R2*). A unique “on-and-off” pattern in T1-weighted signal intensity, which was closely related to tumor hypoxia level, was triggered by 16% O2 breathing but not 100% O2 breathing. When combined with hypoxic gas breathing, oxygen-sensitive MRI may reveal tumor hypoxia threshold, which is important for assessing the efficacy of hypoxia-activated prodrugs. |
| 633 | 17:15
|
Magnetic Resonance Angiography Reveals Increased Arterial Blood Supply and Tumorigenesis Following High Fat Feeding in a Mouse Model of Triple-negative Breast Cancer |
1Radiology, The University of Chicago, Chicago, IL, United States, 2Medicine, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, The University of Chicago, Chicago, IL, United States, 3Pathology, The University of Chicago, Chicago, IL, United States, 4Medicine, the Section of Hematology and Oncology, The University of Chicago, Chicago, IL, United States |
||
Breast cancer is the most commonly diagnosed malignancy among women in the US. Epidemiology shows that a high animal fat diet increases risk of triple-negative breast cancer (TNBC). Our previous work examined the effect of pre-pubertal exposure to high dietary animal fat in the SV40Tag mouse model of TNBC. We showed that a high animal fat diet changes mammary fat composition and increases incidence and aggressiveness of mammary cancers in this model. Here, we demonstrate using MR angiography that changes in fat composition and cancer incidence are paralleled by increases in vascular density in the mammary gland. |
| 634 | 17:27
|
Mapping of Glioma Metabolism Using In Vivo Deuterium Metabolic Imaging (DMI) |
1Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 2Department of Psychiatry, Yale University, New Haven, CT, United States, 3Department of Biomedical Engineering, Yale University, New Haven, CT, United States |
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Deuterium Metabolic Imaging (DMI) is a novel approach providing high 3D spatial resolution metabolic data from both animal models and human subjects. DMI relies on 2H MRSI in combination with administration of 2H-labeled substrates. In a rat glioma model we show how DMI combined with administration of [6,6’-2H2]-glucose and [2H3]-acetate allowed spatial mapping of differences in metabolism between normal brain and glioma. DMI data after infusion of 2H-labeled glucose revealed high glucose uptake and lactate production but limited glucose oxidation in glioma. Furthermore, DMI revealed acute therapeutic effects of a drug (dichloroacetate) targeting glucose oxidation. |
| 635 | 17:39
|
COX-2 Alters the Metabolic Secretome in Triple Negative Human Breast Cancer Xenografts |
1Division of Cancer Imaging Research, Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States, 2McGill University Health Centre and RI-MUHC, Montreal, QC, Canada, 3Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States |
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Tumor interstitial fluid (TIF) contains the tumor secretome and forms a critical component of the tumor microenvironment. Cyclooxygenase-2 (COX2) mediates the inflammatory response of cells and is upregulated in cancers. In cancers, COX-2 expression has been related to increased invasion and metastasis. Here, for the first time, using 1H MR spectroscopy we characterized changes in the metabolic patterns of TIF in tumors derived from triple negative SUM-149 human breast cancer cells with COX-2 overexpressed. COX-2 overexpression significantly altered several fundamental metabolic pathways. These data provide new insights into the role of COX-2 in tumor aggressiveness, and identify new metabolic targets. |
| 636 | 17:51
|
PI3K/mTOR inhibition of IDH1 mutant glioma leads to reduced 2HG production that is associated with increased survival |
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States |
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Mutant IDH1 produces the oncometabolite 2HG, which drives tumorigenesis in low-grade gliomas. One potential therapeutic option for such gliomas is treatment with a PI3K/mTOR inhibitor. Using cell models genetically-engineered to express mutant IDH1, we observed that PI3K/mTOR inhibition induced a reduction in 2HG levels in treated cells and tumors, that was associated with reduced cell proliferation and enhanced animal survival. The drop in 2HG was due to a reduction in its synthesis from both glucose and glutamine. Our study identifies MRS-detectable metabolic alterations that could serve as indicators of response for mutant IDH1 glioma patients undergoing treatment with PI3K/mTOR inhibitors. |
| 637 | 18:03
|
Ketone measurement in human glioma following an Atkins-based diet |
1Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Department of Radiology, Wake Forest School of Medicine, Winston, NC, United States, 5Departments of Neurology and Oncology, Wake Forest School of Medicine, Winston, NC, United States |
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Recent studies have focused on the use of ketogenic diet (KD) in the treatment of glioma since tumor cells are heavily glucose-dependent. Here, we assess the ability of MRS to monitor KD-therapy in glioma patients. Using a semi-LASER sequence at 3 T, with fully simulated basis for spectral fitting, we measured increases in acetone and β-hydroxybutyrate after KD in tumor and contralateral brain. NAA concentration decreased in contralateral brain and there was an observed elevation of β-hydroxybutyrate in IDH-mutated gliomas; potentially indicating differential response to KD. These results indicate a potential for MRS in monitoring KD-based therapy in glioma. |
| W07 | Tuesday 17:15 - 18:15 | (no CME credit) |
| S02 | Tuesday 18:30 - 20:30 | (no CME credit) |
| W05/06 | Tuesday 18:30 - 20:30 | (no CME credit) |
Organizers: Stephan Maier, Jennifer McNab, Noam Shemesh
| N03 | Wednesday 7:00 - 7:50 | Moderators: Bruce Damon |
| 7:00 | Heart |
| Martijn Froeling |
| 7:25 | Skeletal Muscle |
| José Raya |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Jongho Lee, Utaroh Motosugi, Yi-Fen Yen
| N04 | Wednesday 7:00 - 7:50 | Moderators: Utaroh Motosugi & Yi-Fen Yen |
| 7:00 | Basic Physics of Fingerprinting |
| Dan Ma |
| 7:25 | Clinical Applications of Fingerprinting |
| Jeffrey Sunshine |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Kathryn Fowler, Kartik Jhaveri, Lorenzo Mannelli, Valeria Panebianco, Scott Reeder, Reiko Woodhams
| S01 | Wednesday 7:00 - 7:50 | Moderators: Peter Gibbs & Reiko Woodhams |
| 7:00 | Pre-Treatment Breast Imaging |
| Francesco Sardanelli |
| 7:25 | Monitoring Response |
| Amy Fowler |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: James Carr, Bernd Wintersperger
| S02 | Wednesday 7:00 - 7:50 | Moderators: Amedeo Chiribiri & Phillip Young |
| 7:00 | Acquisition Strategies: Contrast-Enhanced & NCE Approaches |
| Krishna Nayak |
| 7:25 | Understanding Contrast Mechanisms, Contrast Agents & Perfusion Models |
| Smita Sampath |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Guanshu Liu, Natalie Serkova, Damian Tyler
| S03 | Wednesday 7:00 - 7:50 | Moderators: Christin Sander & Natalie Serkova |
| 7:00 | Recent Technical Developments of Molecular Imaging for Neurodegenerative Diseases |
| Youssef Wadghiri |
| 7:25 | Clinical Translation & Applications of Molecular MRI in Neurodegenerative Diseases |
| Robia Pautler |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Eric Chang, Garry Gold, Emily McWalter, Edwin Oei, Philip Robinson
| S04 | Wednesday 7:00 - 7:50 | Moderators: James MacKay & Mary Kate Manhard |
| 7:00 | MRI of Bone Microarchitecture |
| Chamith Rajapakse |
| 7:25 | MRI of Bone in the Clinic |
| Gregory Chang |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Andre Obenaus, Pia Maly Sundgren
| S05 | Wednesday 7:00 - 7:50 | Moderators: Norbert Campeau |
| 7:00 | Cannabis - Functional MRI & Cannabis |
| Christopher Whitlow |
| 7:25 | Adolescents & Developing Reward Circuitry |
| Matthew Wall |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Gregor Adriany, Matthias Günther, Michael Hansen, Christoph Juchem, Greig Scott
| S06 | Wednesday 7:00 - 7:50 | Moderators: Christoph Juchem & Greig Scott |
| 7:00 | Consumer-Grade Microcontrollers and Considerations for MRI Console Development |
| Sergei Obruchkov |
| 7:25 | Waveform Generator Tutorial: RF Vector Modulator |
| Natalia Gudino |
| 7:50 | Adjournment & Meet the Teachers |
| Exhibition Hall 2158-2189 | Wednesday 8:15 - 10:15 | (no CME credit) |
| Exhibition Hall | Wednesday 8:15 - 9:15 | (no CME credit) |
| Exhibition Hall | Wednesday 8:15 - 9:15 | (no CME credit) |
| W07 | Wednesday 8:15 - 9:15 | (no CME credit) |
Organizers: Jeff Bulte, Steven Conolly, Lawrence Wald
| S01 | Wednesday 8:15 - 10:15 | Moderators: Jeff Bulte & Lawrence Wald | (no CME credit) |
8:15
|
Basic Physics & Principles of MPI | |
1Preclinical Imaging, Bruker BioSpin MRI GmbH, Ettlingen, Germany |
8:45
|
Towards Functional Magnetic Particle Imaging (fMPI): A Rodent Hypercapnia Cerebral Blood Volume Study | |
1Massachusetts General Hospital, United States |
9:00
|
MPI Cell Tracking: How Does It Compare to MRI? | |
1Johns Hopkins University, Baltimore, MD, United States |
9:15
|
Advanced MPI Hardware with 1 Micromolar Sensitivity & Early MPI Preclinical Imaging Applications | |
1Magnetic Insight |
9:30
|
MRI Meets MPI: How to Build a Hybrid Scanner | |
9:45
|
Panel Discussion |
Organizers: Linda Moy
| W05/06 | Wednesday 8:15 - 10:15 | (no CME credit) |
8:15
|
Ultrafast & Non-Contrast Breast Screening | |
8:45
|
Preoperative & WB Staging with MRI & PET/MRI | |
1Medizinische Universität Wien |
9:15
|
7T & Advanced Breast Spectroscopy | |
1University Medical Center Utrecht, Netherlands |
9:45
|
Radiogenomics in Breast Cancer: New Approaches Towards Diagnosis & Treatment | |
1Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States |
Organizers: Wolfgang Bogner, Gregory Metzger
| S03 | Wednesday 8:15 - 10:15 | Moderators: Wolfgang Bogner & Greg Metzger |
8:15
|
Basic Principles for Imaging Non-Proton Nuclei | |
1NYU Langone Medical Center, United States |
||
Non-proton MRI (X-nuclei MRI) can provide new information on living tissues that is not available with proton (1H) MRI. Certain X-nuclei such as sodium (23Na), phosphorus (31P), oxygen (17O), potassium (39K), Chlorine (35Cl), and others, play an important role in the body metabolism (such as ion homeostasis, propagation of action potential, energy metabolism) and can also be detected with magnetic resonance imaging. |
8:40
|
Sodium (23Na) & Imaging Membrane Potential | |
1Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany |
||
Ions such as sodium (Na+), chlorine (Cl-) and potassium (K+) play an important role in many cellular physiological processes. In healthy tissue, the extracellular concentration of Na+ is approximately ten-fold higher than the intracellular concentration. A breakdown of this concentration gradient or an increase of the intracellular Na+ content can be used as an early marker in many disease processes. In this presentation, the focus will be on musculoskeletal and brain-related applications of Na+ MRI. In addition, the required hardware, as well as image acquisition and post-processing techniques that are suitable for Na+, K+, and Cl- MRI will be discussed. |
9:05
|
Multinuclear Spectroscopy & Imaging of 31P & 13C | |
1University Bern, Switzerland |
||
Early in history of MR, the enormous added value of multinuclear MRI/MRS has been recognized; however, the technical challenges (low sensitivity, difficult volume selection, need for extra hardware, no generally available internal concentration standards, etc.) limited the applications considerably. In particular 13C and 31P can serve as reporters in many metabolic pathways and increased membrane turnover in tumor biology. Ultrahigh field strengths and hyperpolarized 13C substances overcome now many of the obstacles and foster new applications. The lecture shall emphasize the added value, summarize the methodological limitations, and list some representative applications of 13C- and 31P-MRI/MRS. |
9:30
|
Exploring Metabolism with 17O | |
1University of Minnesota, United States |
||
In recent years, with technology advancement and increasing availability of the high/ultrahigh field MR scanners, in vivo 17O MR spectroscopy & imaging has emerged as a valuable tool for noninvasively exploring metabolism in living organ or tissue because of the greatly improved 17O MR sensitivity at higher field. Quantifying regional cerebral metabolic rate of oxygen (CMRO2) and its changes in animal or human brains may be the most important use of 17O MR. In this talk, I will present an overview of the 17O MRS/MRI technique, including the key aspects of the methodology and examples of potential applications. |
9:55
|
Panel Discussion |
10:20
|
Adjournment & Meet the Teachers |
Organizers: Eric Chang, Garry Gold, Emily McWalter, Edwin Oei, Philip Robinson
| W03/04 | Wednesday 8:15 - 10:15 | Moderators: Kimberly Amrami & Richard Hodgson |
8:15
|
Upper-Extremity Peripheral Nerve Imaging with US: European Perspective | |
1University of Genova, Italy |
||
The value of US to assess the most common disorders affecting peripheral nerves in the upper extremity, including compressive neuropathies, polyneuropathies, traumatic injuries, tumours and tumour-like lesions, will be discussed. A careful US approach with thorough understanding of soft-tissue planes and extensive familiarity with anatomy are prerequisites for obtaining reliable information regarding such kind of examination. US can provide a low-cost and noninvasive imaging, speed of performance, and important advantages over MR imaging, including higher spatial resolution and ability to explore long segments of nerve trunks in a single study and to examine tissues in both static and dynamic states with real time scanning. |
8:40
|
Upper-Extremity Peripheral Nerve Imaging with MRI: European Perspective | |
1Spital Thurgau AG, Switzerland |
||
MR neurography has become the modality of choice to image the peripheral nerves of the upper extremity. This talk will provide a comprehensive overview from a European perspective. |
9:05
|
Lower-Extremity Peripheral Nerve Imaging with US: American Perspective | |
1Univ. of San Diego, VA Medical Center, United States |
9:30
|
Lower-Extremity Peripheral Nerve Imaging with MRI: American Perspective | |
1Radiology, NYU School of Medicine, United States |
||
Entrapment neuropathies present a challenge to clinicians and radiologists alike. MR neurography has proven a reliable, non invasive, diagnostic method to identify that exact site of nerve entrapment and the associated direct and indirect MR signs of neuropathy. |
9:55
|
Panel Discussion |
10:20
|
Adjournment & Meet the Teachers |
| Power Pitch Theater A - Exhibition Hall | Wednesday 8:15 - 9:15 | Moderators: Ergin Atalar & Shaihan Malik | (no CME credit) |
| 638 | 8:15
|
Reducing Radiofrequency-induced Heating in Realistic Deep Brain Stimulation Lead Trajectories using Parallel Transmission |
1Physical Sciences, Sunnybrook Research Institue, Toronto, ON, Canada, 2Baylis Medical, Mississauga, ON, Canada, 3Massachusetts General Hospital, Boston, MA, United States, 4Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada |
| 639 | 8:15
|
Electrical lengthening to improve electromagnetic simulations and SAR calculations of meandered body dipole elements at 7T |
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, United Kingdom |
| 640
|
8:15
|
SAR Calculations in Transmit-Only-Receive-Only RF systems: A Comparison of Detuning Methods for Rx Array Coils and their Implementation in EM Simulations |
1Computer Assisted Clinical Medicine,Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany |
| 641
|
8:15
|
Sensitivity analysis of Peripheral Nerve Stimulation modeling: Which model parameters actually matter? |
1Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 2A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 3Harvard Medical School, Boston, MA, United States, 4Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States |
| 642
|
8:15
|
Validating and Measuring Transfer Functions of Straight Wires using a Combination of an Electro-optic Field Sensor and Simulation |
1Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 2German Consortium of Translational Cancer Research Freiburg Site, German Cancer Research Center (DKFZ), Heidelberg, Germany, 3BIOLAB Technology AG, Zürich, Switzerland |
| 643 | 8:15
|
Imaging Conditions and Image Quality for Patients with MR-conditional Implantable Medical Devices: Normal Volunteer Study |
1Course of Electric and Electronic Engineering, Graduate School of Engineering, Tokai University, Hiratsuka, Japan, 2Graduate School of Science and Technology, Tokai University, Hiratsuka, Japan, 3Department of Radiology, School of Medicine, Tokai University, Isehara, Japan |
| 644
|
8:15
|
Wireless MR-Compatibility Control of Active Implantable Medical Devices |
1National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey, 2REHIS Power Amplifier Technologies, Aselsan, Ankara, Turkey, 3Electrical and Electronics Engineering, Bilkent University, Ankara, Turkey |
| 645 | 8:15
|
Experimental implementation of test-field diversity method for RF-induced heating assessment of medical implants |
1IT'IS Foundation, Zurich, Switzerland, 2ETH-Zurich, Zurich, Switzerland |
| 646 | 8:15
|
SMART tracking: SiMultaneous Anatomical imaging and Real-Time needle tracking |
1Image Sciences Institute, UMC Utrecht, Utrecht, Netherlands |
| 647 | 8:15
|
MRI Safety Assessment of Orthopedic Implants on the Bone Surface via the Induced Tangential E-Fields |
1ITIS Foundation, Zurich, Switzerland, 2Department of Physics, Aristotle University of Thessaloniki, Thessaloniki, Greece, 3Center for Devices and Radiological Health (CDRH), US Food and Drug Administration (FDA), Silver Spring, MD, United States, 4Swiss Federal Institute of Technology (ETH), Zurich, Switzerland |
| 648 | 8:15
|
A Reproducible and Lower-Cost Thermo-Acoustic Ultrasound System for Detection of RF-Induced Lead Tip Heating in MRI |
1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Procyon Engineering, San Jose, CA, United States |
| 649 | 8:15
|
An Aerosol-Deposited Wireless Resonant Marker for Catheter Tracking in Interventional MRI |
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Quest Integrated, LLC, Kent, WA, United States, 3UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, CA, United States |
| 650 | 8:15
|
Actively-tracked metallic electrophysiology catheters and guidewires with miniature floating radio-frequency traps: Theory, Design and Validation |
1Cardiology, Johns Hopkins University, Baltimore, MD, United States, 2Radiology, Stanford University, Stanford, CA, United States, 3Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 4Abbott Inc., Saint Paul, MN, United States |
| 651 | 8:15
|
AN ACTIVE BIOPSY NEEDLE DESIGN FOR MRI GUIDED PROSTATE BIOPSY |
1Biomedical Engineering, Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey |
| 652
|
8:15
|
MRI-guided robotic arm (MgRA) drives optogenetic activation of the rat corpus callosum |
1Research Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Graduate Training Centre of Neuroscience, University of Tuebingen, Tuebingen, Germany, 3The Werner Reichardt Centre for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany |
| Power Pitch Theater B - Exhibition Hall | Wednesday 8:15 - 9:15 | Moderators: Aaron Hess & Daniel Hoinkiss | (no CME credit) |
| 653
|
8:15
|
The spatial distribution of arterial and venous vessels in the human brain |
1Nuclear medecine and radiobiology, Université de Sherbrooke, Sherbrooke, QC, Canada, 2Medecine, Université de Sherbrooke, Sherbrooke, QC, Canada, 3Diagnostic radiology, Université de Sherbrooke, Sherbrooke, QC, Canada |
| 654 | 8:15
|
A spatiotemporal fetal MRI atlas for multi-organ segmentation and growth analysis |
1School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom |
| 655
|
8:15
|
Accelerated high b-value diffusion-weighted MRI for higher-order diffusion analysis using a phase-constrained low-rank tensor model |
1Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, United States, 2Radiation Oncology, University of Michigan, Ann Arbor, MI, United States |
| 656 | 8:15
|
Construction of Spatiotemporal Infant Cortical Surface Atlas of Rhesus Macaque |
1Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States |
| 657
|
8:15
|
Efficient Super-Resolution in Intracranial Vessel Wall Magnetic Resonance Imaging using 3D Deep Densely Connected Neural Networks |
1Department of Bioengineering, UCLA, Los Angeles, CA, United States, 2Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States |
| 658 | 8:15
|
Simultaneous Relaxometry and Segmentation of Human Brain through a Deep Neural Network |
1Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA, United States |
| 659
|
8:15
|
Combining Multi-Site/Study MRI Data: A Novel Linked-ICA Denoising Method for Removing Scanner and Site Variability from Multi-Modal MRI Data |
1Imaging Center, Harvard Medical School, McLean Hospital, Belmont, MA, United States, 2Dalian University of Technology, Dalian, China, 3Oxford University, Oxford, United Kingdom, 4Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, United States, 5University of Arizona, Tucson, AZ, United States |
| 660
|
8:15
|
Real-time simultaneous shim and motion measurement and correction in CEST MRI using Double volumetric Navigators (DvNavs) |
1MRC/UCT Medical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa, 2Athinoula A. Martinos Center for Biomedical imaging/MGH, Charlestown, MA, United States, 3Department of Radiology, Harvard Medical School, Boston, MA, United States, 4Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, 5Cape Universities Body Imaging Centre (CUBIC-UCT), Cape Town, South Africa |
| 661 | 8:15
|
Real-time motion and dynamic transmit/receive B1 correction of CEST in the human brain at 7T |
1High-Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Department of Physics, University of Helsinki, Helsinki, Finland, 3Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 4Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States |
| 662 | 8:15
|
Brainstem abnormalities in structural MRI of young children with Autism Spectrum Disorder: evaluation of inter-method agreement. |
1INFN, Pisa, Italy, 2Humanities and Social Science, University of Strathclyde, Glasgow, United Kingdom, 3IRCCS Stella Maris, Pisa, Italy |
| 663 | 8:15
|
Automatic Segmentation of 3D Perivascular Spaces in 7T MR Images Using Multi-Channel Fully Convolutional Network |
1Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States |
| 664
|
8:15
|
Motion artifact quantification and localization for whole-body MRI |
1Section on Experimental Radiology, University Hospital of Tuebingen, Tuebingen, Germany, 2Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany, 3Department of Radiology, University Hospital of Tuebingen, Tuebingen, Germany |
| 665
|
8:15
|
Tract-Based Cluster Analysis |
1Natbrainlab, Forensic and Neurodevelopmental Science, King's College London, London, United Kingdom, 2Department of Neuroimaging, King's College London, London, United Kingdom, 3Department of Psychology, King's College London, London, United Kingdom, 4The Sackler Institute for Translational Neurodevelopment, King's College London, London, United Kingdom |
| 666 | 8:15
|
SEGUE: a Speedy rEgion-Growing algorithm for Unwrapping Estimated phase |
1Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom |
| 667 | 8:15
|
The Role of Partial Volume Modelling in Longitudinal Automated Multiple Sclerosis Lesion Segmentation |
1Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 2Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 3Signal Processing Laboratory (LTS 5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, 5Neuroimmunology Unit, Neurology, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 6Neurology Department and Neuroimaging Laboratory, Basel University Hospital, Basel, Switzerland, 7Medical Image Analysis Laboratory (MIAL), Centre d'Imagerie BioMédicale (CIBM), Lausanne, Switzerland |
Organizers: Andre Obenaus, Elna-Marie Larsson
| S02 | Wednesday 8:15 - 10:15 | Moderators: Andre Obenaus & Elna-Marie Larsson |
8:15
|
How to Optimise Spinal Cord MR Acquisitions | |
1Radiology, Vanderbilt University Medical Center, Nashville, TN, United States, 2Vanderbilt Univeristy Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States |
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The goal of this educational presentation is to develop an understanding of where spinal cord MRI is, its optimization, and impediments to future optimization. We will study what spinal cord optimization means and how improvements can have a real, sustained impact on the radiological and scientific community. We will identify needs, both patient and research centered, that could be addressed with improved spinal cord imaging methods. We will close by asking, “if we know what we need to have, and can identify some of the impediments to those needs, how do we optimize a spinal cord examination for maximal impact?” |
| 668
|
8:45
|
In vivo visualization of white and gray matter sub-structures using fast quantitative T1 mapping of the human spinal cord at 7T with 300-µm in-plane resolution |
1Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, 2iLab-Spine - Laboratoire international - Imagerie et Biomécanique du rachis, Marseille, France, 3APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 4Division of MRI Research, Department of Radiology, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, United States |
||
T1 mapping of the cervical spinal cord at 7T with a 300-µm in-plane resolution using the MP2RAGE sequence is presented. A semi-automated post-processing pipeline enabled group studies (n=10 healthy subjects) with quantitative evaluation within small spinal cord sub-structures from C1 to C7, explored for the first time using T1 mapping. This work lays the groundwork for improved characterization of spinal cord degeneration using 7T MRI, by allowing investigation within particular relevant regions such as the anterior/posterior gray matter horns and ventromedial white matter tracts. It also offers new perspectives to build dedicated spinal cord substructures templates. |
| 669 | 8:57
|
Spinal cord MRI and fMRI at 16.4 T during spinal cord stimulation in rats: initial experience |
1Center for Magnetic Resonance in Research, University of Minnesota, Minneapolis, MN, United States, 2A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, 3Neural Engineering Laboratory, Mayo Clinic, Rochester, MN, United States, 4Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, United States |
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This study aims at paving the way for spinal cord MRI and fMRI during spinal cord stimulation (SCS) in rats, with the goal of providing an experimental framework for assessing the impact of SCS on neuroplasticity and functional circuitry. MRI and fMRI of the spinal cord during SCS are extremely challenging due to motion and electrode-induced susceptibility artefacts. Here we demonstrated that high quality MRI and fMRI images of the spinal cord could be obtained at 16.4T during SCS with recently developed MB-SWIFT. This is the first study that attempts spinal cord fMRI during SCS in rats. |
9:09
|
Clinical Applications of Spinal Cord MR | |
1Medical University of Vienna, Austria |
| 670 | 9:39
|
Spinal Cord MRS Biomarkers of Clinical Impairment in Chronic Spinal Cord Injury |
1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2Department of Radiology, Swiss Paraplegic Centre, Nottwil, Switzerland, 3Max-Planck-Institute for Biological Cybernetics, Tuebingen, Germany, 4Spinal Cord Injury Center, University Hospital Balgrist, University of Zurich, Zurich, Switzerland, 5Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, London, United Kingdom, 6Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, United Kingdom, 7Department of Neurophysics, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 8Institute of Physics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany |
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Remote neurodegenerative changes above the level of injury are present following traumatic spinal cord injury (SCI), resulting in atrophy of the cervical cord of up to 30%. This study investigates the underlying biochemical changes at the cellular and molecular level which may subtend the development of atrophy using latest magnetic resonance spectroscopy in the spinal cord in healthy controls and SCI patients. Furthermore, we screen for potential MRS biomarkers investigating the association of biochemical changes and clinical outcome. |
| 671 | 9:51
|
Comparison of cervical cord results from a quantitative 3D multi-parameter mapping (MPM) protocol of the whole brain with a dedicated cervical cord protocol |
1Queen Square MS Centre, University College London, London, United Kingdom, 2Spinal Cord Injury Center Balgrist, University of Zurich, Zurich, Switzerland, 3Neurophysics Department, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 4NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 5Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada, 6Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, United Kingdom, 7Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 8Brain MRI 3T Centre, C. Mondino National Neurological Institute, Pavia, Italy |
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We present a comparison of cervical cord metrics obtained using both a whole brain and dedicated cord implementation of a recently introduced quantitative multi-parametric MRI protocol which provides apparent proton density, R1, magnetisation transfer saturation (MTsat) and R2* maps sensitive to microstructural tissue changes in brain and spinal cord. Similar whole cervical cord (levels C1-C5) parameters were obtained using either protocol, and inter-subject variation was low, however in order to investigate tissue-specific cord parameters the dedicated cord protocol with higher in-plane resolution would be desirable. |
| 672 | 10:03
|
1H-[13C]-NMR Investigations of Neuronal and Astroglial Metabolic Activity in Spinal Cord and Brain in Amyotrophic Lateral Sclerosis |
1NMR Microimaging and Spectroscopy, Centre for Cellular and Molecular Biology, Hyderabad, India |
||
Amyotrophic lateral sclerosis (ALS) is neurodegenerative disorder resulting from selective loss of both upper and lower motor neurons leading to progressive muscle weakness and paralysis. In the present study, we have used 1H-[13C]-NMR spectroscopy in conjunction with infusion of [1,6-13C2]glucose to evaluate neurometabolic activity in SOD1G37R mouse model of ALS. Our finding suggest reduced levels of glutamate, NAA, NAAG, and increased concentration of myo-inositol in spinal cord. More interestingly, the metabolic activity of glutamatergic and GABAergic neurons is decreased in the spinal cord, while it was increased in the cerebral cortex indicating strikingly different pathology in spinal cord and brain. |
10:15
|
Adjournment & Meet the Teachers |
| N01 | Wednesday 8:15 - 10:15 | Moderators: Sairam Geethanath & Nicole Seiberlich |
| 673 | 8:15
|
Game of Learning Bloch Equation Simulations for MR Fingerprinting |
1Department of Radiology, Case Western Reserve University, Cleveland, OH, United States |
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An MR fingerprinting (MRF) dictionary can be difficult to generate, especially when the dictionary calculation involves complicated physics. We present a new method, named MRF-GAN, based on the generative adversarial network (GAN) to create MR fingerprints. We demonstrate that MRF-GAN can generate accurate MRF fingerprints and the associated in vivo MRF maps comparing to the conventional MRF dictionary. Moreover, it can significantly reduce the dictionary generation time which opens the door to rapid calculation and optimization of MRF dictionaries with more complex physics. |
| 674
|
8:27
|
Optimal Experiment Design for Magnetic Resonance Fingerprinting: New Insights and Further Improvements |
1Athinoula A. Martinos Center for Biomedical Imaging, Chalestown, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Electrical Engineering, University of Southern California, Los Angeles, CA, United States, 4Radiology, Case Western Reserve University, Cleveland, OH, United States |
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The Cramer-Rao bound (CRB) based experiment design was previously described to optimize the SNR efficiency of MRF experiments. Here we revisit such a problem and provide new insights. Specifically, we present a new CRB-based experiment design approach, which introduces an additional set of constraints on the variation of flip angles to enforce the smoothness of the magnetization evolution. We demonstrate that the proposed approach is advantageous for highly-undersampled MRF experiments. We evaluated the effectiveness of the proposed approach with both simulations and phantom experiments. |
| 675
|
8:39
|
Cardiac Magnetic Resonance Fingerprinting in Heart Transplant Recipients |
1University Hospital (CHUV) / University of Lausanne (UNIL), Lausanne, Switzerland, 2Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 3Centre for BioMedical Imaging (CIBM), Lausanne, Switzerland |
||
Cardiac MRF (cMRF) has recently emerged as a method of rapidly characterizing myocardial tissue. It has been shown to be robust to different and varying heart rates with high reproducibility in T1 and T2 regardless of the length and regularity of the cardiac cycle. While these techniques have been validated in healthy volunteers, patient studies have yet to be performed. Therefore, in this abstract, we present the first use of cMRF in a patient population - heart transplant recipients - and show initial results. |
| 676
|
8:51
|
Learning Contrast Synthesis from MR Fingerprinting |
1Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, United States, 2International Computer Science Institute, Berkeley, CA, United States, 3Philips Research Europe, Hamburg, Germany |
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MR fingerprinting provides quantitative parameter maps from a single acquisition, but it also has the potential to reduce exam times by replacing traditional protocol sequences with synthetic contrast-weighted images. We present an empirical "artifact noise" model that makes it possible to train neural networks that successfully transform noisy and aliased MRF signals into parameter maps, which are then used to synthesize contrast-weighted images. We also demonstrate that a trained neural network can directly synthesize contrast-weighted images, bypassing incomplete simulation models and their associated artifacts. |
| 677 | 9:03
|
MR Fingerprinting for High Resolution Metabolic Imaging of Hyperpolarized [1-13C]Pyruvate |
1Department of Radiology & Biomedical Imaging, UCSF, San Francisco, CA, United States, 2GE Healthcare, San Francisco, CA, United States, 3Department of Electrical Engineering, Stanford University, Stanford, CA, United States |
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The purpose of this study was to investigate a new application of MR fingerprinting (MRF) methods for hyperpolarized 13C MRI. We show that introducing randomization of pulse parameters into a 13C SSFP acquisition train facilitates efficient extraction of individual hyperpolarized 13C metabolite levels based on their transient signal responses (i.e. "fingerprints"), in simulations as well as phantom and in vivo experiments. Application of MRF methods in this multi-spectral SSFP framework enables exploitation of the long T2 relaxation times of 13C nuclei for increased sensitivity and spatial resolution in hyperpolarized MRI. Initial results show that MRF approaches have great potential for application to hyperpolarized 13C metabolic imaging. |
| 678 | 9:15
|
MR Vascular Fingerprinting during Gas Challenges |
1Radiology, Stanford University, Stanford, CA, United States |
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The MR vascular fingerprinting (MRvF) approach extends the concept of MR fingerprinting to the study of microvascular properties and functions. Encouraging results have been obtained in healthy human volunteers as well as in stroke and tumor models in rats. However, it has been suggested that the method has a low sensitivity to blood oxygenation measurements. In this study, we tested the MRvF approach in healthy volunteers while breathing different gas mixtures (Hyperoxia (100%O2), Normoxia (21%O2), hypoxia (14%O2)) and examined the results when different types of fingerprints are considered. |
| 679 | 9:27
|
Correlation of MR fingerprinting with whole mount histopathology reveals epithelial and stromal density drive T1, T2 measurements in regions of prostatitis and prostate cancer: Preliminary findings |
1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Radiology, Case Western Reserve University, Cleveland, OH, United States, 3Radiology, University Hospitals, Cleveland, OH, United States, 4Pathology, University Hospitals, Cleveland, OH, United States, 5Urology, University Hospitals, Cleveland, OH, United States |
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Magnetic Resonance Fingerprinting (MRF) is a new technology aimed at generating quantitative T1 and T2 maps. In this study, histo-morphometric attributes that may be driving the MRF measurements of cancerous and prostatitis regions are explored via correlation of in vivo MRF maps with post surgical ex vivo histopathology. Our results suggest that epithelial density may be driving T1 and T2 MRF measurements in prostatitis regions while stromal density may be driving the T1 MRF signals within cancerous regions. |
| 680
|
9:39
|
Quantification of Long and Ultra-short Relaxation Times in Tissues with Ultra-short TE MR Fingerprinting (UTE-MRF) |
1Center for Brain Imaging Science and Technology, Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, China, 2State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China |
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Magnetic resonance fingerprinting (MRF) has been combined with ultra-short echo time technique (UTE-MRF) to enable the quantification of ultra-short T2/T2* tissues. A TE sinusoidal variation pattern is introduced to UTE-MRF acquisition to improve the ultra-short T2 detection accuracy to sub-millisecond. With the golden angle spiral acquisition and sliding window reconstruction, quantitative T1 and T2 maps of regular and ultra-short T2/T2* tissue components are acquired at 14s per slice. Since the B0 induced phase variation has been encoded into the signal evolution with variable TE, the B0 map is simultaneously obtained. |
| 681 | 9:51
|
Water-Fat Separation in Spiral Magnetic Resonance Fingerprinting using Conjugate Phase Reconstruction |
1Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Philips Research Hamburg, Hamburg, Germany |
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Water-fat separation can improve the quality of tissue parameter maps in quantitative imaging methods such as Magnetic Resonance Fingerprinting (MRF). We propose such a technique that uses the B0 map as prior information for spiral off-resonance correction through conjugate phase reconstruction, enabling efficient water-fat separation with only two echo points per frame, implemented in a single run MRF approach. With this technique, accurate tissue parameter maps can be produced in the presence of fat. |
| 682 | 10:03
|
Repeatability of 2D FISP MR Fingerprinting in the Brain at 1.5T and 3.0 T |
1IMAGO7 Foundation, Pisa, Italy, 2National Institute for Nuclear Physics, Pisa, Italy, 3IRCCS Fondazione Stella Maris, Pisa, Italy, 4Unit of Neuroradiology, AOUP, Pisa, Italy, 5Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy, 6Department of Computer Science, Technische Universitat Munchen, Munich, Germany, 7GE Healthcare, Munich, Germany, 8Cancer Research UK Cambridge Institute, University of Cambridge, UK, Cambridge, United Kingdom, 9Department of Radiology, University of Cambridge, Cambridge, United Kingdom |
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MR Fingerprinting is a new multi-contrast imaging method that is appealing for its ability to acquire multiple quantitative maps efficiently when compared to other repeated acquisitions varying a single parameter at a time. This work shows our first demonstration of MRF in vivo repeatability through test/re-test imaging of seven healthy human volunteers at 1.5T and 3.0T. We found the group root-mean-square-difference (NRMSD) of MRF-SSFP T1 measurements to be 5-6% in grey and white matter at 1.5T and 4-5% at 3.0T, T2 NRMSD to be 6-9% at 1.5T and 11-13% at 3.0T, and PD NRMSD to be 2-3% at 1.5T and 2-3% at 3.0T. |
| N02 | Wednesday 8:15 - 10:15 | Moderators: Emilie Bollache & Alejandro Roldan-Alzate |
| 683 | 8:15
|
Comprenhensive analysis of Hemodynamics parameters in patients with bicuspid aortic valve using 4D flow data and a finite element method. |
1Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile, 2Department of Electrical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 3Department of Cardiology, Hospital Universitari Vall d´Hebron, Vall d´Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain, 4Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile, 5Department of Structural and Geotechnical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 6Department of Radiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile |
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Bicuspid aortic valve (BAV) is the most common congenital cardiac defect. Current criteria to support surgical decision in BAV patients has been recently questioned, which motivates the development of better biomarkers to assess the disease stage of development. In this work, we extensively analyze several hemodynamics parameters in volunteers and BAV patients from 4D flow MRI using a finite-element-based quantification framework. We found that the backward velocity fraction, the circumferential WSS, and turbulence parameters, can be used together with the diameters of the vessel as a new risk marker, as it can strongly discriminate subjects from BAV patients. |
| 684
|
8:27
|
Accelerated abdominal 4D flow MRI using 3D golden-angle cones trajectory |
1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States, 3Applied Sciences Laboratory, GE Healthcare, San Diego, CA, United States |
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4D flow MRI enables comprehensive abdominal evaluation, but long acquisition times and motion corruption limit its clinical applicability. To address these limitations, we present a 4D flow sequence with a 3D golden-angle reordered cones sampling trajectory. Cones has high sampling efficiency to allow for vastly accelerated scan times, and excellent aliasing properties that diffuse respiratory and bowel motion artifacts. To further improve motion-robustness, respiratory signals are estimated from each cone readout, and then used to suppress motion during reconstruction. We show that these techniques can be combined to achieve high quality abdominal 4D flow renderings in under 5 minutes. |
| 685
|
8:39
|
PC-MRI with Phase Recovery from Multiple Wrapped Measurements (PRoM) |
1Electrical and Computer Engineering, The Ohio State University, Columbus, OH, United States, 2Cardiac MR R&D, Siemens Medical Solutions USA, Inc., Columbus, OH, United States, 3Richard M. Ross Heart Hospital, The Ohio State University, Columbus, OH, United States, 4Internal Medicine, The Ohio State University, Columbus, OH, United States, 5Biomedical Engineering, The Ohio State University, Columbus, OH, United States |
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In traditional phase-contrast MRI (PC-MRI), the strength of velocity encoding gradient (VENC) offers a tradeoff between the velocity-to-noise ratio (VNR) and the extent of phase wrapping. In contrast, dual-VENC (DV) acquisition achieves the VNR associated with lower of the two VENCs, with higher VENC measurement solely used to perform phase unwrapping1. Here, we demonstrate that the phase unwrapping can be more effective from two low-VENC measurements, where both VENC values are below the peak velocity. The proposed method, called Phase Recovery from Multiple wrapped measurements (PRoM), enables computationally simple yet near-optimal estimation of unwrapped phase (velocity) from multiple wrapped measurements. |
| 686
|
8:51
|
Inefficient Right Heart Function in Preterm Adults as shown with 4D Flow MRI |
1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 2Pediatrics, University of Wisconsin - Madison, Madison, WI, United States, 3Radiology, University of Wisconsin - Madison, Madison, WI, United States |
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Infants born preterm often have impaired pulmonary function, but little is known regarding long-term implications on right-heart function as these patients reach adulthood. We performed 4D flow MRI during rest and exercise in young adults born preterm and age-matched controls to compare their right heart function and efficiency. While flow and velocity in the pulmonary artery appeared similar in both groups, preterm subjects demonstrated increased kinetic energy in the right ventricle (RV) per unit of ejected blood. Pathline visualizations in the right ventricle suggested less structured filling during diastole. These data suggests decreased RV efficiency in preterm adults. |
| 687 | 9:03
|
Highly accelerated 4D flow in the aorta with compressed sensing, respiratory controlled adaptive k-space reordering and inline reconstruction |
1Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc., Columbus, OH, United States, 2Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 3Department of Biomedical Engineering, Northwestern University, Chicago, IL, United States, 4Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc., Chicago, IL, United States, 5Siemens Healthcare, Erlangen, Germany |
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The clinical application of 4D flow is limited by its long acquisition time. Recently, sparse sampling and compressed sensing (CS) reconstruction have been combined with 4D flow to speed up the image acquisition. However, most of CS reconstructions are implemented offline with long reconstruction times, making them infeasible for use in clinical settings. We developed a highly accelerated 4D flow with CS and Respiratory Controlled Adaptive k-space Reordering (ReCAR) acquisition to enable a 3-minute aortic protocol with isotropic 2.5mm voxels and fast 5-minute inline reconstruction. Initial volunteer tests show a good match of flow quantification results with the conventional technique. |
| 688 | 9:15
|
Real-time and self-gated flow using a golden-angle spiral trajectory |
1Cardiovascular Interventions Program, National Heart, Lung & Blood Institute, Bethesda, DC, United States, 2Biochemistry and Biophysics Center, National Heart, Lung & Blood Institute, Bethesda, DC, United States |
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Beat-to-beat measurements of cardiac output have been demonstrated as a valuable diagnostic tool during interventional cardiovascular MR procedures with physiological provocations such as exercise. This preliminary study investigates the potential of golden-angle spiral imaging for combined real-time and retrospectively-binned flow measurements at rest and during exercise. In flow phantoms and human subjects, good agreement was observed between reference Cartesian measurements and self-gated spiral acquisitions at rest. During exercise, real-time and self-gated spiral imaging measured an increase in cardiac output, demonstrating this technique’s potential application to interventional MRI. |
| 689 | 9:27
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Multi-vendor validation and reproducibility of 4D flow MRI using 4-fold parallel imaging acceleration with and without respiratory gating |
1Clinical Physiology, Department of Clinical Sciences, Skane University Hospital, Lund University, Lund, Sweden, 2Department of Biomedical Engineering, Faculty of Engineering, Lund University, Lund, Sweden, 3Lund University Bioimaging Center, Lund University, Lund, Sweden, 4Philips Healthcare, Lund, Sweden, 5Siemens Healthcare AB, Malmö, Sweden, 6Siemens Healthcare GmbH, Erlangen, Germany |
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4D-flow sequences on two 1.5T scanners from different vendors (Philips Achieva dStream and Siemens MAGNETOM Aera) were validated head-to-head. 4D-flow in a pulsatile flow phantom showed high accuracy and precision compared to reference laser particle image velocimetry for both scanners. 2D-flows in ascending and descending aorta and pulmonary trunk were compared to 57 4D-flow scans in 10 subjects. Lower bias for flow volumes was found on Aera (-4.7±12.5%) compared to Achieva (-18.0±20.1%). Kinetic energy showed lower bias for repeated examinations at the same scanner compared to different scanners the same day. 4D-flow without respiratory gating on Aera showed acceptable quality. |
| 690 | 9:39
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Hemodynamic Assessment of the Post-Myocardial Infarction Left Ventricle with 4D Flow MRI |
1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Medicine, University of Wisconsin-Madison, Madison, WI, United States, 3Medicine, Weill Cornell Medical College, New York, NY, United States, 4Radiology, Weill Cornell Medical College, New York, NY, United States, 5Radiology, University of Wisconsin-Madison, Madison, WI, United States |
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This work employed high resolution time resolved (4D) flow cardiac MRI (CMR) to characterize altered left ventricular (LV) flow physiology after anterior myocardial infarction (MI). 4D Flow CMR was used to quantify LV velocity (parallel to the LV long axis) at pre-specified landmarks in the basal, mid, and apical LV. Post-MI patients with impaired global LV function had reduced peak systolic velocity in all regions compared to age-matched controls (p<0.05). A difference in flow patterns between the LV base and apex was also discerned in post-MI patients, characterized by a marked reduction and prolongation of forward flow in the apex. |
| 691 | 9:51
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4D flow MRI Improves Dissection Flap Fenestration Detection in Type B Aorta Dissection |
1Radiology, Northwestern University, Chicago, IL, United States, 2Biomedical Engineering, Northwestern University, Chicago, IL, United States |
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Type B aortic dissections involve the aortic arch/descending aorta with false lumen patency/thrombosis, and size of entry tears identified as predictors of adverse events. These parameters suggest a complex hemodynamic environment that is poorly assessed by current diagnostic tools. The presence of additional fenestrations in the dissection flap likely also alters false lumen hemodynamics. 4D flow MRI offers a comprehensive assessment of 3D aortic hemodynamics in type B dissection. Our results demonstrate that 4D flow can detect nearly two-times the number of dissection flap fenestrations relative to time-resolved MRA, suggesting the potential for improved hemodynamic characterization of these patients. |
| 692 | 10:03
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Comprehensive 3D flow characterization in patients with Dilated Cardiomyopathy from 4D flow MRI data using a finite element method and 17-Segment Bullseyes |
1Department of Electrical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 2Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile, 3Department of Biomedical Engineering, King's College London, London, United Kingdom, 4Pontificia Universidad Católica de Chile, Santiago, Chile, 5Department of Structural and Geotechnical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 6Department of Radiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile |
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Dilated Cardiomyopathy (DCM) is a disease of the heart muscle characterized by the enlargement of the left ventricle and systolic/ diastolic dysfunction. Cardiac Magnetic resonance (CMR) is the gold standard to measure cardiac function using b-SSFP CINE images1. However, hemodynamic parameters within the ventricles have received less attention. In this work, we present a method that allows a comprehensive assessment of different flow parameters in the left ventricle of DCM patients using a finite element framework over 4D flow data sets. |
| N03 | Wednesday 8:15 - 10:15 | Moderators: Anders Dale & Timothy Shepherd |
| 693 | 8:15
|
Self-Organising Maps Enable Global Searching For Patch Based Segmentations |
1The Australian e-Health Research Centre, Commonwealth Science and Industrial Research Organisation, Brisbane, Australia |
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Most automated MRI tissue-segmentation techniques require whole-brain atlases, which are extremely time-consuming to manually delineate. This inhibits utilisation of complementary structural sequences during segmentation as matching atlases rarely exist. We demonstrate a means of reducing the computational complexity of patch-based segmentation using self-organising maps. This overcomes the need for local-only searching of matching patches and, in turn, the need for complete atlases. We demonstrate this technique’s ability to perform registration-free tissue-segmentation of target images using an atlas that is less than 2% complete. The technique may be used as-is, or for rapidly generating novel whole-brain atlases for other techniques. |
| 694
|
8:27
|
Bayesian Deep Learning for Uncertainty Generation in MR Image Segmentation |
1Department of Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 2Department of Radiology, University of Wisconsin - Madison, Madison, WI, United States, 3Department of Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, 4Department of Psychiatry, University of Wisconsin - Madison, Madison, WI, United States |
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The ability of generating model uncertainty for a predictive system on each prediction is crucial for decision-making, especially in the field of medicine, but it has been a missing part in conventional deep learning models. We propose the utilization of Bayesian deep learning, which combines Monte Carlo dropout layers with the original deep neural network at testing time to enable model uncertainty generation. Its prediction accuracy and the behavior of uncertainty were studied on MRI brain extraction. Its segmentation accuracy outperforms 6 popular methods, and the uncertainty’s reactions to different training set sizes and inconsistent training labels meet the expectation well. |
| 695 | 8:39
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Automated Segmentation of Cerebellar Nuclei from Ultra-High-Field Quantitative Susceptibility Maps with Multi-Atlas Shape Fusion |
1Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, 2Netherlands Institute for Neuroscience, Amsterdam, Netherlands, 3Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 4Medical Physics Group, Jena University Hospital, Jena, Germany, 5Siemens Healthcare GmbH, Erlangen, Germany, 6Department of Neurology, Essen University Hospital, University of Duisburg-Essen, Essen, Germany |
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Multi-atlas segmentation techniques fail to properly represent very small nuclei because of their low overlap in the fusion stage. We present a shape modeling approach that recovers more accurately such small structures, which we apply to the segmentation of the deep cerebellar nuclei. |
| 696 | 8:51
|
Automatic MS lesion segmentation in the spinal cord using deep learning |
1NeuroPoly Lab, Polytechnique Montreal, Montréal, QC, Canada, 2Faculty of Medicine, University of Montreal, Montreal, QC, Canada, 3Montreal Neurological Institute, Montreal, QC, Canada, 4Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 5Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China, 6Department of Radiology, University Hospital of Rennes, Rennes, France, 7Univ Rennes, Inria, CNRS, Inserm, IRISA UMR 6074, VISAGES ERL U-1228, F-35000, Rennes, France, 8Department of Neurology, University Hospital of Rennes, Rennes, France, 9University Hospital of Montpellier, Montpellier, France, 10CRMBM, CNRS, Aix-Marseille University, Marseille, France, 11CEMEREM, Hôpital de la Timone, AP-HM, Marseille, France, 12Department of Neurology, CHU Timone, APHM, Marseille, France, 13Neuroimaging Research Unit, INSPE, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 14Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 15Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 16Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada |
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Detection of multiple sclerosis (MS) lesions in the spinal cord |
| 697 | 9:03
|
Automated segmentation of calibration regions for pediatric whole brain T1- and T2-weighted ratio myelin mapping |
1Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia, 2Neuroscience Research, Murdoch Children's Research Institute, Melbourne, Australia, 3Neurosurgery, The Royal Children's Hospital, Melbourne, Australia, 4Medical Imaging, The Royal Children's Hospital, Melbourne, Australia, 5Paediatrics, University of Melbourne, Melbourne, Australia, 6Radiology, University of Melbourne, Melbourne, Australia, 7Epilepsy, Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, 8Neurology, The Royal Children's Hospital, Melbourne, Australia, 9Victorian Infant Brain Study (VIBeS), Murdoch Children's Research Institute, Melbourne, Australia, 10Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, 11School of Psychological Sciences, Monash University/Monash Institute of Cognitive and Clinical Neurosciences, Melbourne, Australia, 12Medicine, Monash University, Melbourne, Australia |
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Delineation of calibration regions is a key component of the T1w/T2w ratio myelin mapping approach. The existing method implemented in SPM was not designed for pediatric MRI application. We have developed an automated approach that is able to reliably segment appropriate calibration regions in the pediatric populations- the CSF and scalp fat layer. Using two pediatric MRI datasets, we demonstrated reliability of our segmentation method and the low variance of regional T1w/T2w ratios than the existing method. Our proposed calibration method has potential to be implemented in pediatric myelination studies using the whole brain T1w/T2w ratio technique. |
| 698 | 9:15
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Brain Tissue Segmentation and Subcortical Parcellation: How Reliable Are Different Tools? |
1Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany, 2MRI.Tools GmbH, Berlin, Germany, 3Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 4Department of Neurology, University Medicine Greifswald, Greifswald, Germany |
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Volume based morphometry is a well-established tool to investigate changes of brain structures in neurodegenerative diseases, and a variety of implementations is available. With MRI investigations as an indispensable instrument for diagnosis and disease progress monitoring, the question about reliability and robustness of these tools arises. This work examines the accuracy of CAT 12 and FreeSurfer by comparing a selection of their calculated subcortical volumes to a ground truth. |
| 699 | 9:27
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A novel strategy for automated near-real-time segmentation of the ventral-intermediate (VIM) nucleus for deep brain stimulation (DBS) surgery |
1Electrical and Computer Engineering, University of Arizona, Tucson, AZ, United States, 2Surgery, University of Arizona, Tucson, AZ, United States, 3Medical Imaging, University of Arizona, Tucson, AZ, United States |
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Direct visualization of thalamic nuclei using MRI has been challenging for applications such as Deep Brain Stimulation (DBS) surgery for treatment of essential tremor, where the ventral intermediate (VIM) nucleus is targeted. Current methods are mainly based on Diffusion Tensor Imaging (DTI) which is limited by low spatial resolution and distortion of EPI as well as manual post processing such as seeding specific areas to identify the cerebro thalamic tract. We have developed a novel strategy that combines a white-matter nulled MPRAGE sequence followed by fast near-real time automated segmentation of thalamic nuclei, which can be tailored for each patient for accurate targeting of the VIM nucleus. |
| 700 | 9:39
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Convolutional neural network based segmentation of the the spinal cord and intramedullary injury in acute blunt spinal cord trauma |
1Radiology and Biomedical Imaging, Zuckerberg San Francisco General Hospital and UCSF, San Francisco, CA, United States, 2Brain and Spinal Injury Center, San Francisco, CA, United States, 3Institute of Biomedical Imaging, NeuroPoly Lab, Polytechnique Montreal, Montreal, QC, Canada |
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This study aims to develop and validate a convolutional neural network for automatic segmentation of the spinal cord (SC) and intramedullary injury in acute blunt SC trauma patients. Using image augmentation of the axial slice cross section and U-net architecture, we were able to achieve a dice coefficient for SC segmentation of 0.92. The same network architecture was also able to identify areas of intramedullary injury. This is the first study to accurately segment the acute blunt trauma SC. Automatic segmentation of the SC in this population makes automatic biomarker analysis and quantitative prognostication of outcomes possible for SC injury. |
| 701 | 9:51
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High resolution T1-weighted brain imaging and segmentation at 7T: a travelling head study |
1School of Physics and Astronomy, University of Nottingham, Sir Peter Mansfield Imaging Centre, Nottingham, United Kingdom, 2Nuffield Department of Clinical Neurosciences, University of Oxford, Wellcome Centre for Integrative Neuroimaging (FMRIB), Oxford, United Kingdom, 3School of Psychology, Cardiff University, Cardiff University Brain Research Imaging Centre, Cardiff, United Kingdom, 4Department of Clinical Neurosciences, University of Cambridge, Wolfson Brain Imaging Centre, Cambridge, United Kingdom, 5University of Glasgow, Institute of Neuroscience & Psychology, Glasgow, United Kingdom |
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Ultra-high magnetic field (7T) MRI scanners can provide high spatial resolution images and excellent contrast for classifying brain tissue in vivo, but imaging reproducibility and tissue segmentation between sites is key for multi-site studies. Here, we present a travelling-head study focusing on the harmonized acquisition and segmentation of T1-weighted images acquired on three subjects at 0.7mm3 isotropic resolution at four different 7T sites. The aim of the study is to assess the harmonisation and robustness of the MPRAGE and MP2RAGE sequence across sites, by focusing on segmentation reproducibility and T1 estimation. |
| 702 | 10:03
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First Application of Automated Hippocampal Subfield Segmentation using 7T MRI in Patients with Major Depressive Disorder |
1Radiology, Icahn School of Medicine At Mount Sinai, New York, NY, United States, 2Biomedical Engineering, City College of New York, New York, NY, United States, 3Neurosurgery, Icahn School of Medicine At Mount Sinai, New York, NY, United States, 4Biomedical Engineering, University of Pennsylvania, Philadelphia, PA, United States, 5Psychiatry, Icahn School of Medicine At Mount Sinai, New York, NY, United States, 6Population Health Science and Policy Department, Icahn School of Medicine At Mount Sinai, New York, NY, United States, 7Radiology, Mount Sinai Medical Center, New York, NY, United States, 8Neuroscience, Icahn School of Medicine At Mount Sinai, New York, NY, United States |
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Major depressive disorder (MDD) is a debilitating illness, which is widely prevalent. There is a need to elucidate MDD pathophysiology to better target treatment. Studies have shown association between hippocampal subfield volumes and MDD, making the subfields potential biomarkers. We use high-resolution 7T-MRI to perform effective subfield delineations and evaluate subfield volume differences between sixteen patients and sixteen controls. Using automatic segmentation of hippocampal subfields software revealed a trend towards reduced right-CA1 and right-DG subfield volumes in patients compared to controls. Identifying hippocampal subfield volumes as imaging biomarkers for MDD may help design more targeted treatments for the disease. |
| N04 | Wednesday 8:15 - 10:15 | Moderators: Luis Hernandez-Garcia & Nadine Graedel |
| 703
|
8:15
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A Novel Method for Direct Detection and Spatial Mapping of Neuronal Activity |
1Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea, 2Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Republic of Korea |
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Although BOLD-fMRI is widely used for in-vivo functional brain mapping, there has been continuing interest in the possibility of using MRI to directly detect the neuronal activity. However, previous works failed to reach a clear consensus on that possibility. Here, we proposed a novel method for direct detection and spatial mapping of neuronal activity with temporal resolution on the order of the action-potential duration(4~5ms). We demonstrated its feasibility using an ex-vivo squid axon and an insulated copper-wire in an event-related electrical-stimulation paradigm. The results are very exciting and promising, although the underlying contrast mechanism needs to be elucidated. |
| 704 | 8:27
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Mapping Neural Circuitry at High Speed (10Hz) using functional Magnetic Resonance Elastography (fMRE) |
1Radiology, Brigham & Women's Hospital, Boston, MA, United States, 2Radiology, Harvard Medical School, Boston, MA, United States, 3Imaging Sciences and Biomedical Engineering, Kings College London, London, United Kingdom, 4Neuroradiology, University Medical Center Goettingen, Goettingen, Germany, 5Biomedical Engineering, Boston University, Boston, MA, United States, 6Mechanical Engineering, Boston University, Boston, MA, United States, 7Physics, University of Erlangen, Erlangen, Germany, 8Informatics, University of Oslo, Oslo, Norway, 9Biomedical Engineering, ETH, Zurich, Switzerland |
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Using MR elastography, the shear modulus of a mouse brain was monitored during noxious stimulation. Localized changes in tissue elasticity of >10% were observed in previously identified regions associated with noxious stimuli. The observed mechanical response persists over two decades of stimulus frequencies from 0.1-10 Hz. This demonstrates the mechanism behind the change in stiffness is not of vascular origin, which has a much slower response than 10Hz. but rather is either directly related to, or tightly coupled to primary neuronal activity. This opens a new window to explore the spatio-temporal processing of signals in the brain. |
| 705 | 8:39
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Hypercapnia-induced vasodilatation increases brain stiffness |
1Berlin Center for Advanced Neuroimaging, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Bernstein Center for Computational Neuroscience, Berlin, Germany, 3Institute of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 4Institute of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany |
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Cerebral MR elastography paired with arterial spin labelling was applied to a group of healthy male subjects during a hypercapnia challenge to analyze the interrelation between cerebral blood flow and mechanical properties of brain tissue in vivo. Hypercapnia-induced vasodilation and the associated increase in blood perfusion was accompanied by a highly significant increase in global cerebral stiffness by 3% (p<0.0001). |
| 706 | 8:51
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High resolution single-vessel fMRI with the radial encoding method |
1Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2Graduate Training Centre of Neuroscience, Tübingen, Germany |
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A golden angle radial encoding (GARE) method was implemented to map BOLD signal from individual venules penetrating the rat somatosensory cortex with 50 μm spatial resolution. This real-time acquisition method makes it possible to detect the hemodynamic signal from individual vessel with much finer spatial scale than previously reported methods. It also provides high flexibility to define the field of view to only focus on the activated brain regions and increase the sampling rate for fMRI imaging. This GARE method improves the existing single vessel fMRI method with higher spatiotemporal resolution. |
| 707 | 9:03
|
Functional sodium (23Na) MRI at 7T - Extracellular sodium decreases during cortical activation in the Human brain |
1Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, 2AP-HM, Timone Uinv Hospital, CEMEREM, Marseille, France, 3Computer Assisted Clinical Medicine, Centre for Biomedicine and Medical Technology Mannheim, Heidelberg University, Mannheim, Germany |
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Using dynamic multiecho 3D 23Na MRI with a temporal resolution of 25s, we demonstrated that functional 23Na MRI at 7T was sensitive enough to observe non-invasively in the Human brain, sodium signal variations during a conventional hand motor task. This acquisition performed at 3 different TEs showed that the closest spatial pattern of sodium signal changes relative to BOLD activation was the decrease of 23Na signal at long TE (19ms) assuming to mostly reflect the extracellular sodium changes. This work opens a new ear to better understand normal and abnormal activity-dependent metabolic coupling in the neuro-glia-vasculature ensemble. |
| 708 | 9:15
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BOLD fMRI with 0.5 mm isotropic voxel size and minimal in-plane distortion using 3D planes-on-a-paddlewheel (POP) EPI at 7 Tesla |
1Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia |
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High spatial resolution is essential for blood oxygenation level dependent fMRI of laminar or columnar structures and a voxel size of 0.5 mm would be desirable. With common 2D EPI acquisitions this leads to prohibitively long readout trains, echo times and high in-plane distortions. We therefore propose a 3D POP EPI with minimal in-plane distortion and an echo time dependent on the number of slices that can achieve 0.5 mm isotropic resolution. We further investigate analysis methods based on classical and Bayesian statistical inference for this high-resolution data and show the gained sensitivity when using the Bayesian inference scheme. |
| 709 | 9:27
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Blood-volume imaging using GRASE-VASO at ultra-high field for layer specific fMRI in human brain |
1Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United States, 2Center for Imaging of Neurodegenerative Diseases, Veteran Affairs Health Care System, San Francisco, CA, United States, 3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 4Department of Radiology, Harvard Medical School, Boston, MA, United States, 5Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, 6Advanced MRI Technologies, LLC, Sebastopol, CA, United States |
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Cortical layer-dependent fMRI opens new possibilities for studying neuronal circuitry. Gradient-echo BOLD contrast, which is commonly used for fMRI, suffers from decreased spatial specificity due to BOLD contrast arising in large draining veins. Vascular space occupancy (VASO) and gradient and spin echo (GRASE) acquisition techniques were shown to improve spatial specificity. Here, the technique to acquire BOLD-corrected GRASE-VASO images and its application to fMRI in human motor cortex at 7T are presented. The results suggest increased spatial specificity as compared to EPI-VASO, which could be beneficial for layer-dependent fMRI applications. |
| 710 | 9:39
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Turbo VSASL: slice- and velocity-selective ASL for high temporal resolution functional CBF mapping |
1MGH/HST Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Radiology, Massachusetts General Hospital, Boston, MA, United States, 3Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States |
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Velocity selective (VS) ASL theoretically allows high temporal resolution functional CBF mapping, since the arterial tag is immediately delivered to target microvascultature. This is in contrast to conventional ASL, which suffers from transit delays that limit minimum TR to about one second. VSASL, however, employs a nonselective VS tagging scheme, resulting in incomplete T1 recovery of tagged blood away from the imaging slice, and subsequent signal loss at low TRs. In this study, we introduce a slice-selective VS tag to mitigate T1 recovery effects, and for the first time demonstrate subsecond functional CBF mapping of the visual cortex. The approach is dubbed “Turbo VSASL”. |
| 711 | 9:51
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Band-free whole-brain alternating SSFP fMRI provides distortion-free activation maps in the visual cortex at 7T |
1Center for Biomedical Imaging (CIBM), EPFL, Lausanne, Switzerland |
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Although the potential of bSSFP for fMRI has been previously demonstrated, the use of bSSFP remains limited at high field due to the presence of banding artefacts. We demonstrate here that a modified bSSFP sequence with alternating phase cycles (0/180°) can provide distortion-free and band-free fMRI images at 7 Tesla with a wide coverage (72 mm), and temporal / spatial resolution that match that of conventional EPI (2 mm isotropic, TRvolume=1.7 s), by combining water-selective spectro-spatial pulses and very high undersampling (12-fold) coupled with controlled aliasing (CAIPIRINHA). |
| 712 | 10:03
|
Simultaneous Acquisition reveals Functional Connectivity in Brain and Spinal Cord |
1Stanford University, Palo Alto, CA, United States |
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We investigate resting-state brain and spinal cord functional connectivity of four healthy volunteers by means of a novel dynamic per slice shimming approach. Functional connectivity, between brain and spinal cord, reveals localization to corresponding sensory and motor areas. Our results are consistent with task-based brain-spinal cord activation results using a motor task , suggesting a strong connection of descending and ascending signals with the brain. |
| S04 | Wednesday 8:15 - 10:15 | Moderators: Winfried Willinek & Valeria Panebianco |
| 713 | 8:15
|
Four-dimensional T2-weighted imaging in prostate MRI with T2 shuffling |
1Radiology, Stanford University, Stanford, CA, United States, 2Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, United States, 3Applications and Workflow, GE Healthcare, Menlo Park, CA, United States |
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High-quality T2-weighted imaging is critical in the evaluation of the prostatic transition zone for cancer. We adapted an acquisition technique currently used mostly in musculoskeletal MRI termed T2 Shuffling (T2Sh) by incorporating outer volume suppression (OVS) and optimizing it for the prostate. Our retrospective review of 20 patients assessed T2Sh in the evaluation of the prostate. The overall image quality of T2Sh was comparable to that of 2D T2 FSE with water-fat separation and superior to that of 3D T2 FSE with OVS and water-fat separation. |
| 714 | 8:27
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Added value of magnetic resonance spectroscopic imaging to multiparametric MRI for detection of prostate cancer using PIRADS version 2 |
1Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India, 2Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India, 3Department of Urology, All India Institute of Medical Sciences, New Delhi, India |
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We report increase in sensitivity, specificity and accuracy of PIRADSv2 by addition of MRSI to mpMRI protocol for detection of cancer of prostate (CaP). 26 patients having a biopsy-proven CaP, were investigated at 3.0T using mpMRI including MRSI, followed by radical prostatectomy within 1 month. PIRADSv2 score for mpMRI, PIRADSv1 score for MRSI and Gleason grade group from radical prostatectomy specimens were determined. ROC curve analysis was used to determine the accuracy for cut-offs. A combination of MRSI PIRADSv1 cut-off ≥4 and PIRADSv2 cut-off ≥3 showed the best accuracy (96.2%) for CaP detection. When MRSI was added to PIRADSv2 scoring we found an improvement from 71.4% sensitivity and 91.9% specificity of PIRADSv2 to 91.8% sensitivity and 98% specificity for detecting CaP. |
| 715 | 8:39
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Gleason Probability Maps: A Radiomics Tool for Mapping Tumor Likelihood in MRI Space |
1Biophysics, Medical College of Wisconsin, Wawautosa, WI, United States, 2Radiology, Medical College of Wisconsin, Wawautosa, WI, United States, 3Pathology, Medical College of Wisconsin, Wawautosa, WI, United States, 4Urologic Surgery, Medical College of Wisconsin, Wawautosa, WI, United States |
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Intra and intertumoral heterogeneities are well recognized in prostate cancer. These differences affect the macroscopic imaging contrast characteristics of tumor and surrounding tissue. This study aims to generate three new, interpretable image contrasts by combining radiomic profiling with annotated, whole mount pathology. We show that these new image contrasts, Gleason probability maps, are indicative of prostate cancer in naïve data. |
| 716 | 8:51
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A Patch-Based Convolutional Neural Network Model for the Diagnosis of Prostate Cancer using Multi-Parametric Magnetic Resonance Images |
1Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China, 2Department of Radiology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China, 3MR Scientific Marketing, Siemens Healthcare, Shanghai, China |
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We proposed a patch-based convolutional neural network (CNN) model to distinguish prostate cancer using multi-parametric magnetic resonance images (mp-MRI). Our CNN model was trained in 182 patients including 193 cancerous (CA) vs. 259 normal (NC) regions, and tested independently in 21 patients including 21 CA vs 31 NC regions. The model produced an area under the receiver operating characteristic curve of 0.869, sensitivity of 90.5% and specificity of 67.7% for the differentiation of CA from normal regions, showing its potential for the diagnosis of prostate cancer in clinical application. |
| 717 | 9:03
|
Delineation accuracy of prostate cancer for focal therapy: comparison of MR imaging and histopathology characteristics |
1Radiation Oncology, the Netherlands Cancer Institute, Amsterdam, Netherlands, 2Radiology, the Netherlands Cancer Institute, Amsterdam, Netherlands, 3Pathology, the Netherlands Cancer Institute, Amsterdam, Netherlands, 4Urology, the Netherlands Cancer Institute, Amsterdam, Netherlands, 5Medical Physics, Aarhus University Hospital, Aarhus, Denmark, 6Oncology, Aarhus University Hospital, Aarhus, Denmark, 7Radiation Oncology, University Hospitals Leuven, Leuven, Belgium |
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The success of any focal therapy for prostate cancer relies on accurate tumor detection and delineation. Currently there are no guidelines for delineation of prostate tumors. In this study we showed that radiologists are better in delineating parts of tumors with Gleason pattern 4 and 5 than Gleason pattern 3, but still the sensitivity (0.56) needs to be improved for focal therapy and volume estimation. |
| 718 | 9:15
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Measurement using 3D-FSE-T2WI is useful in predicting early recovery of continence following radical prostatectomy in patients with prostate carcinoma. |
1Radiology, University of Yamanashi Hospital, Chuo-shi, Japan, 2Urology, University of Yamanashi Hospital, Chuo-shi, Japan |
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We conducted a prospective study to examine if preoperative anatomical evaluation of the urethra using 3D-FSE-T2WI is useful in predicting early recovery of continence following total prostatectomy in patients with prostate carcinoma. The length of the membranous urethra (8.4±1.7 mm vs. 5.7±0.6 mm, p=0.005) and the thickness of the pelvic diaphragm (10.8±1.4 mm vs. 8.8±0.5 mm, p=0.01) were significantly different between the patients who achieved continence and those who did not achieve continence 1 month after surgery. A longer membranous urethra and thicker pelvic diaphragm measured using 3D-FSE-T2WI are correlated to earlier recovery of continence following radical prostatectomy. |
| 719 | 9:27
|
How to improve the equivocal category PI-RADS score 3? Quantitative multiparametric MRI assessment of prostate cancerous and non-cancerous areas using correlative histopathology. |
1Department of Radiology, Sapienza University, Policlinico Umberto I, Rome, Italy |
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To stratify patients with PI-RADSv2 category 3 to define the correct diagnostic work-up (biopsy or follow-up), quantitatively analyzing mpMRI parameters (ADC, k-trans, K-ep and ve). Among 1272 men who underwent mpMRI, we retrospectively enrolled 98 patients treated with radical prostatectomy. Furthermore, we selected 100 negative patients. The 198 mpMRI exams were randomly, blindly reviewed by two radiologists. 95 PI-RADSv2 category 3 were found and quantitatively analyzed. ROC and AUC were determined to identify a cut-off value to define which PI-RADS 3 lesion should be biopsied. Quantitative imaging represents a tool to objectively stratify patients classified as PI-RADSv2 category 3. |
| 720 | 9:39
|
Patient-Specific 3D Printed and Augmented Reality Prostate Cancer Models Derived from MRI Data: Initial Results from Prospective Clinical Study |
1Center for Advanced Imaging Innovation and Research (CAI2R) and Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, NY, United States, 2Division of Urologic Oncology, Department of Urology, NYU School of Medicine, New York, NY, United States |
||
The objective of this study was to determine whether patient-specific 3D printed and augmented reality prostate cancer models derived from multi-parametric MRI data can influence pre-surgical planning and patient outcomes for patients undergoing robotic assisted radical prostatectomy. Initial results from our prospective study are presented. |
| 721 | 9:51
|
Quantitative mDixon Fat Fraction can differentiate metastatic nodes from benign nodes in prostate cancer patients. |
1Centre of Medical Imaging, UCL, London, United Kingdom, 2Nuclear Medicine, UCLH, London, United Kingdom, 3Physics, UCL, London, United Kingdom, 4Centre for Medical Imaging, UCL, London, United Kingdom |
||
Metastatic nodes in prostate cancer are associated with poor prognosis. Conventional MRI, relying on short-axis diameter (SAD) suffers from poor accuracy in identifying metastatic nodes. In this study, we compare fat fraction signal from MRI mDixon acquisitions (FF) with apparent diffusion coefficients of nodes and quantitative contrast-enhanced two-point mDixon T1 images (CE-mDixon), in discriminating between benign and metastatic nodes using 18F-Choline PET-CT as reference standard. We showed that FF and CE-mDixon discriminate benign from involved lymph nodes that are small in size unlike SAD or ADC of nodes; FF, not necessitating contrast agents, holds promise as a clinical tool. |
| 722
|
10:03
|
Diffusion MRI Detects and Differentiates Inflammation from Cancer Cells in Prostate Cancer Patients |
1Radiology, Washington University School of Medicine, St. Louis, MO, United States, 2Radiology, Changhai Hospital, Shanghai, China |
||
Recent consensus suggested PCa detection based on mpMRI lacks necessary sensitivity or specificity to differentiate prostatitis from PCa, which results in over-diagnosis and over-treatment. Our novel method, diffusion MRI histology (D-Histo), demonstrated its ability to accurately localize, quantify and distinguish between PCa and prostatitis. D-Histo’s improved diagnosis accuracy could more effectively guide treatment planning and assess treatment efficacy. |
| S05 | Wednesday 8:15 - 10:15 | Moderators: Qiyong Gong & Mark Meadowcroft |
| 723 | 8:15
|
Reversal of Behavioral and Metabolic Deficit with Withania Somnifera in Alzheimer's Disease Mice: A 1H-[13C]-NMR Study |
1NMR Microimaging and Spectroscopy, Centre for Cellular and Molecular Biology, Hyderabad, India |
||
Alzheimer’s disease (AD) is a degenerative disorder and the most common cause of dementia. The hallmark of AD is the accumulation of Aβ-plaque in the subject brain. At present there is no treatment for AD. Extracts of Withania somnifera (WS) roots has been shown to promote neurite outgrowth and improve learning and memory in AD mice. The current study examine the effects of WS on neurometabolism in AβPP-PS1 mouse model of AD by using 1H-[13C]-NMR spectroscopy in conjunction with infusion of [1,6-13C2]glucose. Our findings indicate that WS improved learning and memory, and ameliorate the neurometabolism in AβPPPS1 mice. |
| 724
|
8:27
|
Imaging disruption of blood-brain-barrier (BBB) in Mild Cognitive Impairment without using contrast agent |
1Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Department of Neurology, Johns Hopkins University, Baltimore, MD, United States, 3Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, United States |
||
Disruption of BBB in AD has received increasing attention due to its potential role in amyloid accumulation and clearance. However, measurement of BBB leakage in AD has been proven challenging, especially when using non-contrast techniques. In this study, we measured BBB permeability to water in MCI patients using a novel technique that does not require any contrast agent. It was found that MCI patients have a higher permeability-surface-area-product (PS), i.e. leaky BBB, compared to elderly controls. Individuals with higher PS values had poorer cognitive performance and more severe vascular inflammation. These findings support the role of BBB disruption in AD. |
| 725
|
8:39
|
Increased BBB leakage to water but not gadolinium in a rat model of Alzheimer’s disease |
1Division of Neuroscience and Experimental Psychology, The University of Manchester, Manchester, United Kingdom, 2Bioxydyn Ltd, The University of Manchester, Manchester, United Kingdom, 3Bioxydyn Ltd & Division of Informatics, Imaging, and Data Sciences, The University of Manchester, Manchester, United Kingdom |
||
The presence of blood-brain barrier (BBB) dysfunction in patients with Alzheimer’s disease (AD) is unclear. This study uses a novel MRI approach to study AD and age-related alterations in BBB leakage to water (PSw) and gadolinium (Ktrans) in a transgenic rat model of AD. We show PSw is increased in transgenic animals relative to wild-types but that Ktrans is independent of genotype. This study demonstrates the benefit of probing the BBB with molecules of different sizes, and suggests measurements of BBB permeability to water are more sensitive to AD-related BBB alterations than estimates of gadolinium leakage. |
| 726 | 8:51
|
Non-invasive Assessment of Glymphatic Inflow: Measurement of Perivascular Fluid Movement using Diffusion Tensor MRI |
1Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 2Francis Crick Institute, London, United Kingdom, 3Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, University College London, London, United Kingdom, 4Leonard Wolfson Experimental Neurology Centre, UCL Institute of Neurology, University College London, London, United Kingdom |
||
The glymphatic system may play a critical role in the parenchymal clearance of amyloid beta, a leading molecular candidate to initiate Alzheimer’s disease. Clinical investigation, however, is currently hindered by an absence of non-invasive techniques for assessment. The movement of fluid in the perivascular space represents a central component of the glymphatic pathway. Here, we present the first non-invasive evaluation of glymphatic function by using an ultra-long echo-time, low b-value, diffusion-tensor sequence targeted to the perivascular space of the rat brain. We demonstrate that this novel technique is sensitive to the fluid movement along perivascular channels that drives glymphatic inflow. |
| 727 | 9:03
|
Multinuclear MR and PET for Studying Energetic Adaptations in Individuals at Increased Risk for Alzheimer’s Disease |
1Department of Radiology, NYU School of Medicine, New York, NY, United States, 2Department of Neurology, Weill Cornell Medical College, New York, NY, United States, 3Department of Psychiatry, NYU School of Medicine, New York, NY, United States |
||
31P-MRS directly assesses metabolites linked to cellular metabolism, which may be altered at the early stages of Alzheimer’s disease (AD). A major challenge for 31P-MRS is the low sensitivity of the 31P nucleus. Therefore, 31P-MRS has only been used sporadically in AD research. To address this, we built a highly-sensitive dual-nuclei (31P/1H) radio frequency coil array and acquired whole-brain 31P-MRS data from cognitive normal subjects at increased risk for AD, who had previously received FDG and amyloid-PET evaluations. Our goal was to detect energetic abnormalities in this pre-clinical population and compare 31P-MRS findings with established PET-based biomarkers of AD. |
| 728 | 9:15
|
Brain 1H-MRS and volumetric changes predict conversion from Mild Cognitive Impairment to Alzheimer’s disease: a follow-up study |
1Functional MR Unit, Policlinico S.Orsola - Malpighi, Bologna, Italy, 2Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy, 3IRCCS Institute of Neurological Sciences, Bologna, Italy |
||
Predicting the possible evolution from the prodromal MCI stage to dementia is a great challenge for both clinic practice and research. We investigated the predictive role of magnetic resonance spectroscopy and brain volumetry in the progression from Mild Cognitive Impairment (MCI) to Alzheimer’s Disease (AD). The (NAA+NAAG)/ml ratio in the Posterior Cingulate Cortex (PCC) discriminates at baseline MCI converters from non-converters with an accuracy of 79% after a mean follow-up of 28 months. Volumetric reduction of the parahippocampal gyrus and fusiform gyrus was also found to be an accurate marker of progression to AD (Accuracy 84.2% and 73.6% respectively). |
| 729
|
9:27
|
Elevated cerebral blood flow in amyloid-positive elderly cognitively normal controls |
1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States, 3Department of Radiology and Biomedical Imaging, University of California – San Francisco, San Francisco, CA, United States |
||
We evaluated the effects of [18F]-Florbetapir PET-derived amyloid (A$$$\beta$$$) status on regional cerebral blood flow (CBF) measured using pulsed arterial spin labeling (PASL) in control subjects from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. Mean CBF in whole grey matter, posterior cingulate and precuneus showed significantly higher CBF in amyloid positive (A$$$\beta$$$+) group compared to the amyloid negative (A$$$\beta$$$-) group after eliminating subjects with poor PASL data quality as assessed by an automated algorithm. Subjects with higher CBF in the A$$$\beta$$$- group also demonstrated better episodic memory whereas a reverse trend was observed in the A$$$\beta$$$+ group. |
| 730 | 9:39
|
Intrinsic Visual Attention Networks and Their Structural Connectivity Reveal Structure-Function Changes of the Visual-Attention System in Subjective Cognitive Decline and Mild Cognitive Impairment |
1Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, 2Department of Psychology, National Taiwan University, Taipei, Taiwan, 3Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan, 4Molecular Imaging Center, National Taiwan University, Taipei, Taiwan, 5Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan |
||
In addition to the memory problems, older adults with mild cognitive impairment (MCI) may suffer from visual-attention problems. We speculated that even at the very early stage such as subjective cognitive decline (SCD), visual-attention function may be affected. We investigated the control, SCD and MCI groups’ functional connectivity of the attention and visual networks and the five association fiber tracts responsible for long-range dorsal and ventral pathways. The ventral attention and ventral visual networks exhibit significant group differences in all functional, structural connectivity and cortical thickness. Our findings suggest that in contrast to the top-down goal-directed dorsal attention and the object location of dorsal visual functions, the ventral attention and ventral visual functions for processing unfamiliar stimuli and object recognition may be changed in SCD and MCI. In summary, the visual-attention functions may be affected in SCD and MCI. |
| 731 | 9:51
|
Development of advanced multiparametric MRI biomarkers of Alzheimer’s disease |
1Translational Bioimaging Group, Barrow Neurological Institute, Phoenix, AZ, United States, 2Magnetic Resonance Technology Design Group, Barrow Neurological Institute, Phoenix, AZ, United States, 3Mayo Clinic - Arizona, Scottsdale, AZ, United States, 4Neurology, Alzheimer’s and Memory Disorders, Barrow Neurological Institute, Phoenix, AZ, United States, 5Human Brain Mapping Laboratory, Barrow Neurological Institute, Phoenix, AZ, United States |
||
The goal of this project is to establish advanced MRI signatures of each stage of Alzheimer’s disease (AD), including preclinical, mild cognitive impairment (MCI), and dementia stages. These advanced imaging methods will allow us to non-invasively investigate the underlying neurobiological changes that precede cognitive impairment. While structural MRI is known to change with disease progression, advanced MR imaging may provide more specific signatures of disease progression. The asymptomatic and MCI phases represent a clear potential for early intervention, and the non-invasive methods developed here may identify patients along the clinical trajectory of AD. |
| 732 | 10:03
|
Lower oxygenation in the peripheral subarachnoid space reflects decreased cerebral blood flow in dementia-related brain structures |
1Radiology, UMC Utrecht, Utrecht, Netherlands, 2UMC Utrecht, Utrecht, Netherlands, 32Danish Research Center for Magnetic Resonance, Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 4Department of Radiology, MR Research, John Hopkins Medical Center, Baltimore, MD, United States |
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We evaluated the relationship between cerebral blood flow (CBF) and T2 of peripheral CSF. The rationale behind this hypothesized association is the presumed dependency of T2 on oxygenation. The T2 of CSF was related to CBF and cognition in a group with cognitive decline. In contrast, no relationship was found between the T2 and CBF in a healthy aging cohort suggesting no relation between the T2 of CSF and oxygenation. Further investigation regarding the relation between T2 of CSF and cognition in the healthy aging cohort are ongoing and could shed light on the value of T2 as a biomarker. |
| S06 | Wednesday 8:15 - 10:15 | Moderators: Els Fieremans Fieremans & Andrada Ianus |
| 733
|
8:15
|
SYNCHROTRON X-RAY PHASE-CONTRAST IMAGING TO SIMULATE DIFFUSION TENSOR MRI: APPLICATION TO TRACTOGRAPHY |
1CREATIS UMR 5220, U1206, University of Lyon, Lyon, France, 2Institut Pascal UMR 6602, Université Clermont Auvergne, Le Puy en Velay, France, 3Laboratoire CarMeN, University of Lyon, Lyon, France, 4Lyon Neuroscience Research Center, Lyon, France, 5LARIS, UMR INRA IRHS, Université d'Angers, Angers, France |
||
As it provides the only method for mapping neural tracts in vivo, diffusion MRI tractography is gaining importance in clinical and neuroscience research. However, the precision of tractography results is influenced by many factors. In this study, we propose a highly realistic simulator based on real data acquired by synchrotron x-ray phase-contrast imaging. This imaging technique with histology-like resolution is demonstrated to reveal adequately the mouse brain in 3D by comparison with classical histology, which loses continuity along the sectioning axis. We expect that our simulator may serve as a tool for the validation and optimization of tractography algorithms. |
| 734
|
8:27
|
Validation of diffusion MRI models and tractography algorithms using chemical tracing |
1Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, 2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 3University of Rochester School of Medicine, Rochester, NY, United States, 4McLean Hospital, Belmont, MA, United States |
||
Brain circuitry is still poorly understood, posing a challenge to the validation of diffusion MRI (dMRI) tractography. Many aspects of tractography algorithms, such as their choice of diffusion model or deterministic vs. probabilistic approach, can impact on their performance. Therefore, beyond a qualitative validation, we need quantitative metrics for comparing and optimizing these algorithms. In this work we perform a systematic evaluation of different diffusion models and tractography algorithms by assessing their accuracy with respect to chemical tracing in macaques. We find that the combination of probabilistic tractography and GQI/DSI model yields the best results, and that accuracy does not always improve with higher angular resolution. |
| 735 | 8:39
|
The existence of the inferior fronto-occipital fasciculus (IFOF) revealed in the non-human primate by ex-vivo diffusion-weighted tractography and blunt dissection. |
1Groupe d’Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives (GIN-IMN) - UMR 5293, CNRS, CEA Université de Bordeaux, Bordeaux, France, 2Division of Neurosurgery, Structural and Functional Connectivity Lab, Azienda Provinciale per i Servizi Sanitari (APSS), Trento, Italy, 3Neurosurgery Unit, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children Hospital, IRCCS, Rome, Italy, 4École d'optometrie, Université de Montréal, Montreal, QC, Canada, 5Laboratory of Neuropsychiatry and Psychiatric Centre Copenhagen, University of Copenhagen, Copenhagen, Denmark, 6Danish Research Centre for Magnetic Resonance, Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 7Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark |
||
The existence of a ventral fronto-occipital association pathway in non-human primates similar to the inferior fronto-occipital fasciculus (IFOF) in humans, is nowadays still largely debated. In this study, we elucidate the existence, course and terminations of such a pathway using in the same non-human primate (vervet monkey) both ex-vivo diffusion-weighted tractography and blunt microdissection. From a methodological point of view, it allows an unprecedented anatomical validation of advanced tractography with microdissection for the first time in the same specimen. |
| 736 | 8:51
|
Post-mortem mapping of cortical layers using combined multicompartmental relaxometry and diffusometry at ultra-high field (7T and 11.7T) |
1UNIRS, CEA/DRF/Neurospin, Gif-sur-Yvette, France, 2Université Paris-Saclay, Orsay, France, 3FLI / Noeud Paris-Sud, Orsay, France, 4Université François-Rabelais de Tours, INSERM, Imagerie et Cerveau UMR 930, Tours, France, 5UNATI, CEA/DRF/Neurospin, Gif-sur-Yvette, France, 6http://cati- neuroimaging.com/, Gif-sur-Yvette, France |
||
The human cerebral cortex has a laminar structure presenting distinct cell organization and myelination. In this work, we compare the lamination observed from multicompartmental quantitative relaxometry- or diffusometry-based microstructural ultra-high field MRI on a post-mortem human brain visual cortex sample. This study reveals that the quantitative intra-neuritic volume fraction map provides a better delineation of the line of Gennari in the primary visual cortex whereas multicompartment T1 relaxometry provides a better segmentation of the superfical layers. Thus, this study strongly plays in favour of a combination of relaxometry and diffusometry methods to robustly map the cortex lamination in humans. |
| 737 | 9:03
|
A tunable permeability phantom for validating time-dependent diffusion models |
1Center For Biomedical Imaging, New York University Medical Center, New York, NY, United States |
||
Well characterized phantoms are essential for time-dependent diffusion model validations. Here we introduce a phantom made of permeable barriers with highly tunable micro-structural characteristics such as pore size, pore density and permeability and perform time-dependent diffusion measurements using three NMR and MRI systems. Our experimental results agree with the theory of time-dependent diffusion in disordered systems, making the phantom suitable for model validations in clinical and preclinical systems. |
| 738 | 9:15
|
A new computational framework for complex numerical simulation of diffusion-weighted NMR signal in brain tissue |
1Computer Science Department and Centre for Medical Imaging Computing, University College London, London, United Kingdom |
||
In this work, we introduce a new framework that we developed to use numerical simulations to investigate the complexity of brain tissue at a microscopic level with a detail never realised before. Directly inspired by the advances in computational neuroscience for modelling brain cells, the proposed toolbox enables numerical simulation of molecular diffusion within realistic digitalised brain cells, such as neurons and glia. Here we show a select set of examples offered by this new toolbox to demonstrate its versatility and potentiality. Further development is ongoing, which will support even more realistic conditions and fully digitalised tissues. |
| 739 | 9:27
|
Monte Carlo simulations of diffusion in mouse corpus callosum reconstructed from 3-d electron microscopy validate the time-dependence along axons |
1Center for Biomedical Imaging, New York University, New York, NY, United States |
||
We present a numerical framework for validation of diffusion models applied to biological tissues. By performing Monte Carlo simulations in a geometry created by automated segmentation of 3-dimensional mouse brain electron-microscopy images, we study the time-dependence of the diffusion coefficient and kurtosis along individual white matter axons, with or without orientation dispersion. Simulation results, together with the analysis of spatial correlations of axonal cross-section variations along axons, point at the short-range disorder in restrictions to diffusion, and agree with theoretical predictions. Our results are consistent with diffusion time-dependence observed in in vivo human brain data. |
| 740
|
9:39
|
Joint modelling of diffusion MRI and histology |
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre (Radboudumc), Nijmegen, Netherlands, 3Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom |
||
Constrained spherical deconvolution determines the orientation of white matter fibres from the diffusion MRI signal. To do so, the diffusion profile of a single fibre is estimated and assumed constant across the sample. However, the diffusion signal is dependent on microstructural properties such as axonal diameter, packing and myelination, which questions the assumption of a single-fibre response function. This multimodal study combines diffusion MRI with histology from the same tissue sample, to test the validity of a ‘brain-wide’ fibre response function. Preliminary results indicate that in practice the fibre response function is indeed dependent on local anatomy. |
| 741 | 9:51
|
Validation of Diffusion Spectrum Imaging of the Human Tongue with Histology |
1Diagnostic Radiology, University of Maryland School of Medicine, Baltimore, MD, United States, 2Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, United States, 3Neural and Pain Sciences and Orthodontics, University of Maryland School of Dentistry, Baltimore, MD, United States, 4Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, United States |
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In this study provides validation procedure for DSI anisotropy measures versus the histological analysis of the aligned tongue muscles. A fresh ex-vivo sample of the tongue is scanned using DSI multi-shell acquisition then the sample is fixed for further histological analysis and comparison with the fiber tracts using DSI reconstruction. The DSI delineation of muscle fibers is matching the histology images of the same region.
|
| 742
|
10:03
|
Histologically-derived fiber response functions for diffusion MRI data reveal systematic differences from model-based deconvolution kernels |
1Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2Vanderbilt University, Nashville, TN, United States, 3Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States |
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Spherical deconvolution for diffusion MRI requires a response function in order to accurately reconstruct the underlying voxel-wise fiber orientation distribution (FOD). Here, using 3D histologically-defined fiber orientation distributions and the corresponding diffusion signal, we derive the ground-truth fiber response functions. We show that there is significant variation in these response functions across the brain. We find that the current methods to estimate this function do not match the histological results, which leads to differences in fiber volume fractions. This is important because the wrong response function can amplify spurious peaks in the FOD and lead to inaccurate tractography. |
| W07 | Wednesday 9:15 - 10:15 | (no CME credit) |
| Plenary Hall (Paris Room) | Wednesday 10:45 - 11:15 |
| 10:45 | When the Right Thing to Do Is Also the Smart Thing to Do: Research & Results on Diversity in Research Organizations |
Organizers: Catherine Hines, Garry Gold, Arvind Pathak, Kelvin Lim
| Plenary Hall (Paris Room) | Wednesday 11:15 - 12:15 | Moderators: Catherine Hines & Arvind Pathak |
| 11:15 | Competition: Point of Care (POC) Diagnostics |
1Duke University, United States |
| 11:35 | Sustainable Low-field MRI for Point of Care Diagnostics |
1Center for Neural Engineering, Penn State University, University Park, PA, United States |
| 11:55 | Complement: Implementing MR into the POC Pipeline |
1Edinburgh Imaging, Dr., Edinburgh, United Kingdom |
| 12:15 | Adjournment |
| Plenary Hall (Paris Room) | Wednesday 12:30 - 13:30 | (no CME credit) |
| Exhibition Hall 2298-2321 | Wednesday 13:45 - 15:45 | (no CME credit) |
| Exhibition Hall | Wednesday 13:45 - 14:45 | (no CME credit) |
| Exhibition Hall | Wednesday 13:45 - 14:45 | (no CME credit) |
| W07 | Wednesday 13:45 - 14:45 | (no CME credit) |
Organizers: Krishna Nayak, Lawrence Wald, Andrew Webb
| N04 | Wednesday 13:45 - 15:45 | (no CME credit) |
13:45
|
Development of a Highly Compact 1.5 T Functional MRI System with Minimal Infrastructural Requirements | |
1Victoria University of Wellington, New Zealand |
14:09
|
Optimization of Permanent Magnet Array for a Portable MR Imager | |
18 Somapah Road, Singapore University of Technology and Design, Singapore, Singapore |
14:33
|
Single-Side NMR Systems & Their Uses in Biomedical Applications | |
1Robinson Research Institute, Victoria University of Wellington, Wellington, New Zealand |
14:57
|
Imaging with Non-Uniform Field Using a Rotating Halbach Magnet | |
1Massachusetts General Hospital, United States |
15:21
|
Millitesla MRI: Improving Signal & Reducing Noise | |
1Radiology, MGH/Martinos Center for Biomedical Imaging |
Organizers: Fan Lam, Chao Ma, Tom Scheenen
| W05/06 | Wednesday 13:45 - 15:45 | Moderators: Fan Lam & Chao Ma | (no CME credit) |
13:45
|
Fast, High-SNR Spectroscopy of Tissue Compartments with SLAM | |
1Radiology, Johns Hopkins University, Baltimore, MD, United States |
14:02
|
Ultrafast MRSI: Recent Advances & Potential Applications | |
1Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States |
14:19
|
On Spatial-Spectral Resolution in Echo-Planar MR Spectroscopic Imaging | |
14:36
|
Parallel Imaging & Spatial-Spectral Encoding Accelerated FID-MRSI at 7T | |
1Medical University of Vienna, Vienna, Austria |
14:53
|
Accelerated Multi-Dimensional MR Spectroscopic Imaging: 2D Spectral+2D/3D Spatial Encoding | |
1Radiology, UCLA Geffen School of Medicine, Lo Angeles, CA, United States |
15:10
|
Spectral Quality in Ultrafast MRSI | |
1University of Pittsburgh, Pittsburgh, PA, United States |
15:27
|
Spectroscopic Imaging Considerations for Hyperpolarized 13C | |
1Radiology, Stanford University, Stanford, CA, United States |
Organizers: Aikaterini Kotrotsou, Christopher Nguyen
| N02 | Wednesday 13:45 - 15:45 | Moderators: Dan Ma & Christopher Nguyen |
13:45
|
Can MRI Provide More Clinical Value? Increasing Utility & Reducing Cost | |
1MD Anderson Cancer Center, United States |
14:05
|
Low Field & Portable MR Hardware | |
1University and ETH Zürich, Switzerland |
14:25
|
Faster Comprehensive Scans | |
1Case Western Reserve University, United States |
14:45
|
Panel Discussion: Industry Perspective to increasing value of MRI | |
1GE Healthcare, United States |
14:45
|
Panel Discussion: Industry Perspective to Increasing Value of MRI | |
1Philips Healthcare, Netherlands |
||
This presentation examines a possible definition of "value in MRI" and offers a non-limiting interpretation from one of multiple possible perspectives of an industrial vendor and research collaborator. The seemingly simple equation defining value, like the Larmor equation, hides a considerable complexity with respect to the paths and dimensions to increasing value. We will examine the components that make up one version of the value equation and offer examples of the technologies, disciplines and strategies that are considered as part of an industrial investment in the development of tools that could increase value when embraced by healthcare professionals and organizations. |
14:45
|
Panel Discussion: Industry Perspective to increasing value of MRI | |
1HealthLytix, San Diego, CA, United States |
||
MRI has been proven to be an extremely important imaging modality for clinical diagnosis, prognosis and monitoring perspective. However, it is also very complicated first from the interface between hardware and software and the variability it generates across different vendor platforms and secondly the abundance of different imaging contrasts leading to ever lengthening of the imaging protocols. My talk will address the current status of MR imaging from a technology, platform & applications perspective and how industry can help & partner with academic institutions to increase value of MRI. |
14:45
|
Panel Discussion: Industry Perspective to Increasing Value of MRI | |
1Siemens Medical Solutions USA, United States |
15:45
|
Adjournment & Meet the Teachers |
| Power Pitch Theater A - Exhibition Hall | Wednesday 13:45 - 14:45 | Moderators: Toshiaki Taoka & Mami Iima | (no CME credit) |
| 743 | 13:45
|
Building a probabilistic atlas of the human corticospinal tract from 410 healthy participants by using enhanced bundle-specific tractography. |
1Groupe d’Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives (GIN-IMN) - UMR 5293, CNRS, CEA Université de Bordeaux, Bordeaux, France, 2Sherbrooke Connectivity Imaging Lab (SCIL), Université de Sherbrooke, Sherbrooke, QC, Canada |
| 744 | 13:45
|
Validation of dentato-rubro-thalamic tract in squirrel monkey brain |
1Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 3Psychology, Vanderbilt University, Nashville, TN, United States, 4Physics and Astronomy, Vanderbilt University, Nashville, TN, United States, 5Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN, United States, 6Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States, 7Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, United States, 8Neurology, Vanderbilt University Medical Center, Nashville, TN, United States |
| 745
|
13:45
|
Assessing the asynchronous macrostructural changes in white matter tracts of the developing brain |
1Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 2Wellcome Centre for Integrative Neuroscience - Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), University of Oxford, Oxford, United Kingdom |
| 746
|
13:45
|
An accurate and efficient infarction segmentation method for diffusion weighted images using a deep convolutional neural network |
1Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China, 2College of Engineering, Peking University, Beijing, China, 3Department of Neurology, Peking Union Medical College Hospital, Beijing, China, 4Department of Neurology, Peking University First Hospital, Beijing, China |
| 747
|
13:45
|
Selective degeneration of crossing fibres and its relationship with fractional anisotropy |
1Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada, 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Departments of Psychiatry and Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, 4MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States |
| 748 | 13:45
|
Quantifying diameter overestimation of undulating axons from synthetic DW-MRI |
1Computer Science, Centro de Investigación en Matemáticas A.C., Guanajuato, Mexico, 2University of Verona, Verona, Italy, 3Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 4Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden, 5Brain and Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 6University Hospital Center (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland |
| 749
|
13:45
|
Diffusion Anisotropy of the Extra-Axonal Environment is Linked to Axon Alignment |
1Department of Neuroscience, Medical University of South Carolina, Charleston, SC, United States, 2Department of Neurology, Medical University of South Carolina, Charleston, SC, United States, 3Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, United States |
| 750
|
13:45
|
Multishot high-resolution brain diffusion-weighted imaging using phase regularized reconstruction |
1Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Electrical Engineering, Stanford University, Stanford, CA, United States, 3Biomedical Engineering, Tsinghua University, Beijing, China, 4GE Healthcare, Menlo Park, CA, United States, 5Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, United States, 6Department of Bioengineering, Stanford University, Stanford, CA, United States |
| 751 | 13:45
|
Reversible white matter restricted diffusion in patients with cerebral malaria via ADC measurement on a 0.35T MR scanner |
1Electrical and Computer Engineering, University of Rochester, Rochester, NY, United States, 2Department of Imaging Sciences, University of Rochester, Rochester, NY, United States, 3Malawi MRI Center, Queen Elizabeth Central Hospital, Blantyre, Malawi, 4Department of Neurology, University of Rochester, Rochester, NY, United States |
| 752 | 13:45
|
Evaluation of Standardized and Study-Specific Diffusion Tensor Imaging Templates of the Adult Human Brain |
1Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States |
| 753 | 13:45
|
Characterization of Axonal Pathology Independent of Fiber Crossings in Multiple Sclerosis Using High-Gradient Diffusion MRI |
1Massachusetts General Hospital, Boston, MA, United States, 2Neurology, Massachusetts General Hospital, Boston, MA, United States |
| 754 | 13:45
|
Anatomy-constrained automated fiber tract reconstruction for surgery planning: a validation study in language-related white matter tracts |
1Translational Imaging Group, University College London, London, United Kingdom, 2Wellcome EPSRC Centre for Interventional and Surgical Sciences (WEISS), University College London, London, United Kingdom, 3Epilepsy Society MRI Unit, Chalfont St Peter, United Kingdom, 4Department of Clinical and Experimental Epilepsy, University College London, London, United Kingdom, 5Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Canada, 6Dementia Research Centre, University College London, London, United Kingdom |
| 755 | 13:45
|
Rapid Single Shot Whole Lung Acquisition of for Hyperpolarized Gas MRI Biomarkers of Airspace Enlargement. |
1Robarts Research Institute, London, ON, Canada, 2Department of Medical Biophysics, Western University, London, ON, Canada, 3Division of Respirology, Department of Medicine, Western University, London, ON, Canada |
| 756 | 13:45
|
The intracellular component of VERDICT (Vascular, Extracellular, and Restricted Diffusion for Cytometry in Tumors) MRI distinguishes Gleason 4 pattern better than Apparent Diffusion Coefficient |
1Centre of Medical Imaging, UCL, London, United Kingdom, 2Centre for Medical Imaging, UCL, London, United Kingdom, 3UCL, London, United Kingdom, 4UCLH, London, United Kingdom |
| 757 | 13:45
|
Validation of the VERDICT MRI Framework using a Novel Computational Model of Diffusion and Flow in Real-World Tumours. |
1Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 2University College London, London, United Kingdom, 3University of Bologna, Bologna, Italy |
| Power Pitch Theater B - Exhibition Hall | Wednesday 13:45 - 14:45 | (no CME credit) |
| 758 | 13:45
|
Double DANTE: an improved method for high-resolution intracranial vessel wall imaging |
1Department of Biomedical Engineering & Physics, Academic Medical Center, Amsterdam, Netherlands, 2Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, Netherlands, 3Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, 4A.A. Martinos Center for Biomedical Imaging, MGH, Harvard Medical School, Boston, MA, United States, 5MR Clinical Science, Philips Healthcare, Markham, ON, Canada, 6Department of Radiology, Utrecht Medical Center, Utrecht, Netherlands, 7Spinoza Centre for Neuroimaging, Amsterdam, Netherlands |
| 759
|
13:45
|
Clinical value of dark-blood late gadolinium enhancement without additional magnetization preparation |
1Department of Radiology, Maastricht University Medical Centre, Maastricht, Netherlands, 2School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 3Department of Cardiology, St Thomas' Hospital, London, United Kingdom, 4Department of Cardiology, Antwerp University Hospital, Antwerp, Belgium, 5British Heart Foundation Centre of Excellence, King's College London, London, United Kingdom, 6Pontificia Universidad Católica de Chile, Escuela de Ingeniería, Santiago, Chile |
| 760 | 13:45
|
Feasibility of Free-Breathing Fetal Cine Cardiac MRI based on Doppler Ultrasound, Compressed Sensing and Motion Compensation |
1Lund University, Skåne University Hospital, Department of Clinical Sciences Lund, Clinical Physiology, Lund, Sweden, 2Laboratory of Computing, Medical Informatics and Biomedical-Imaging Technologies, School of Medicine, Aristotle University, Thessaloniki, Greece, 3Lund University, Skåne University Hospital, Department of Clinical Sciences Lund, Diagnostic Radiology, Lund, Sweden, 4Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 5North medical GmbHMartinistraße 52, 20246, Hamburg, Germany, 6Faculty of Engineering, Lund University, Department of Biomedical Engineering, Lund, Sweden, 7Siemens Healthcare AB, Malmö, Sweden, 8Lund University, Department of Health Sciences, Physiotherapy, Lund, Sweden |
| 761 | 13:45
|
Geometrical Characterization of Marfan and Bicuspid Aortic Valve Patients Using Finite Element Methods |
1Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile, 2Department of Electrical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 3Department of Cardiology, Hospital Universitari Vall d´Hebron, Vall d´Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain, 4Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile, 5Department of Structural and Geotechnical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 6Department of Radiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile |
| 762
|
13:45
|
Myocardial T1 And T2 Mapping Using MR Fingerprinting: Comparison to clinical standards |
1Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, 2Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 3Case Western Reserve University, Cleveland, OH, United States, 4Case Western Reserve University School of Medicine, Cleveland, OH, United States, 5Case Western Reserve University School of Medcine, Cleveland, OH, United States, 6Cardiology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States |
| 763 | 13:45
|
Pericardial Enhancement in Recurrent and Constrictive Pericarditis: Correlation with Pathology in 52 Patients |
1Radiology, Mayo Clinic, Rochester, MN, United States |
| 764 | 13:45
|
Quantitative myocardial perfusion using multi-echo Dixon for respiratory motion correction and arterial input function estimation |
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Federal University of Minas Gerais, Belo Horizonte, Brazil, 3Federal Center for Technological Education of Minas Gerais, Belo Horizonte, Brazil, 4Philips Healt Systems, London, United Kingdom |
| 765
|
13:45
|
Automated 4D Flow Conservation Utilizing Adjacency Matrices |
1Medical Physics, University of Wisconsin Madison, Madison, WI, United States, 2Radiology, University of Wisconsin Madison, Madison, WI, United States |
| 766
|
13:45
|
Rapid Carotid Artery T2 and T1 Mapping Using a Radial TSE and IR-FLASH Approach |
1Department of Medical Imaging, University of Arizona, Tucson, AZ, United States, 2Department of Biomedical Engineering, University of Arizona, Tucson, AZ, United States, 3Electrical and Computer Engineering, University of Arizona, Tucson, AZ, United States, 4Siemens Medical Solutions, Tucson, AZ, United States, 5Department of Surgery, University of Arizona, Tucson, AZ, United States |
| 767
|
13:45
|
Improved phase unwrapping algorithm for automatic cine DENSE strain analysis using phase predictions and region growing |
1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 2Radiology, University of Virginia, Charlottesville, VA, United States |
| 768
|
13:45
|
Myocardial Edema Imaging – A Comparison of Three Techniques |
1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States, 3Department of Cardiology, West China Hospital, Chengdu, China, 4Siemens Healthcare Pte Ltd., Singapore, Singapore |
| 769 | 13:45
|
Prediction for development of cerebral hyperperfusion after carotid endarterectomy using cerebral oxygen extraction fraction map based on quantitative susceptibility mapping at 7T |
1Neurosurgery, Iwate Medical university, Morioka, Japan, 2Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical university, Yahaba, Japan, 3Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan, 4Cyclotron Reserch Center, Iwate Medical university, Takizawa, Japan |
| 770 | 13:45
|
Investigating the use of non-contrast enhanced Magnetic Resonance Multi-Sequence Thrombus Imaging (MSTI) to direct therapy in patients with acute iliofemoral Deep Vein Thrombosis |
1Academic Department of Vascular Surgery, King's College London, London, United Kingdom, 2Vascular Surgery Department, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, 3School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, 4School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom |
| 771 | 13:45
|
Strain Measurements from 3D Isotropic Cine MRI: Relation with Fibrosis in a Duchenne Patient Population |
1IADI, INSERM U947 & Université de Lorraine, Nancy, France, 2CIC-IT 1433, INSERM, Université de Lorraine and CHRU Nancy, Nancy, France, 3Compter Science Department, Technical University Munich, Munich, Germany, 4Department of Cardiothoracic Surgery, CHU Strasbourg and University of Strasbourg, Strasbourg, France |
| 772 | 13:45
|
Optimized respiratory-resolved motion-compensated 3D Cartesian coronary MRA |
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom |
Organizers: Michael Lustig, Demian Wassermann
| N01 | Wednesday 13:45 - 15:45 | Moderators: Leslie Ying & Demian Wassermann |
13:45
|
Introduction to Machine Learning in MR Imaging | |
1INRIA Parietal, United States |
||
Machine learning builds predictive models from the data. It is massive used on medical images these days, for a variety of applications ranging from segmentation to diagnosis.I will give an introductory tutorial to machine learning from a statistical point of view. I will introduce the methodology, the concepts behind the central models, the validation framework and a variety of caveats to look for.I will also discuss some applications to drawing conclusions from brain imaging, and use these applications to highlight various technical issues to have in mind when running machine learning models and interpreting their results. |
14:15
|
Machine Learning for Image Analysis | |
1Imperial College London |
| 773 | 14:45
|
Progressively Distribution-based Rician Noise Removal for Magnetic Resonance Imaging |
1Department of Electronic Information Engineering, Nanchang University, nanchang, China, 2Lauterbur Research Centre for Biomedical Imaging, Shenzhen Key Laboratory for MRI, Shenzhen Institutes of Advanced Technology, Shenzhen, China |
||
Different from the existing MRI denoising methods that utilizing the spatial neighbor information around the pixels or patches, this work turns to capture the pixel-level distribution information by means of supervised network learning. A wide and progressive network learning strategy is proposed, via fitting the distribution at pixel-level and feature-level with large convolutional filters. The whole network is trained in a two-stage fashion, consisting of the residual network in pixel domain with batch normalization layer and in feature domain without batch normalization layer. Experiments demonstrate its great potential with substantially improved SNR and preserved edges and structures. |
| 774 | 14:57
|
Deep neural network based framework for in-vivo axonal permeability estimation |
1Centre for Medical Image Computing and Dept of Computer Science, University College London, London, United Kingdom, 2CENIR, ICM, Paris, France, 3Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France, 4INRIA, Université Côte d'Azur, Sophia-Antipolis, France, 5Parietal, CEA, INRIA, Saclay, Sophia-Antipolis, France, 6AP-HP, Hôpital Saint-Antoine, Paris, France, 7Hôpital de la Pitié Salpêtrière, Sorbonne Universités, UPMC Paris 06 UMR S 1127, Inserm UMR S 1127, CNRS UMR 7225, Institut du Cerveau et de la Moelle épinière, Paris, France, 8AP-HP, Hôpital de la Pitié Salpêtrière, Paris, France, 9Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom |
||
This study introduces a novel framework for estimating permeability from diffusion-weighted MRI data using deep learning. Recent work introduced a random forest (RF) regressor model that outperforms approximate mathematical models (Kärger model). Motivated by recent developments in machine learning, we propose a deep neural network (NN) approach to estimate the permeability associated with the water residence time. We show in simulations and in in-vivo mouse brain data that the NN outperforms the RF method. We further show that the performance of either ML method is unaffected by the choice of training data, i.e. raw diffusion signals or signal-derived features yield the same results. |
| 775 | 15:09
|
Predictive Cytological Topography (PiCT): a Radio-Pathomics Approach to Mapping Prostate Cancer |
1Biophysics, Medical College of Wisconsin, Wawautosa, WI, United States, 2Radiology, Medical College of Wisconsin, Wawautosa, WI, United States, 3Pathology, Medical College of Wisconsin, Wawautosa, WI, United States, 4Biostatistics, Medical College of Wisconsin, Wawautosa, WI, United States, 5Urologic Surgery, Medical College of Wisconsin, Wawautosa, WI, United States, 6Radiation Oncology, Medical College of Wisconsin, Wawautosa, WI, United States |
||
We present a machine learning technique for mapping prostate cancer cellular features into MRI space. 39 patients were prospectively recruited for imaging prior to prostaectomy. Tissue was aligned with the MRI using a non-linear control point warping technique. Pathologist annotations were likewise transformed into MRI space. A partial least squares regression (PLS) algorithm was trained on two sets of 10 patients and applied to 19 test patients, using MRI values as the input to predict epithelial and lumen density. The output maps are new interpretable image contrasts predictive of prostate cancer presence. |
| 776 | 15:21
|
Common pitfalls in machine learning applications to multi-center data: tests on the ABIDE I and ABIDE II collections |
1Physics, University of Pisa, Pisa, Italy, 2National Institute for Nuclear Physics, Pisa, Italy |
||
Applying Machine Learning (ML) techniques on neuroanatomical MRI data, is becoming widespread for studying psychiatric disorders. However, such instruments require some precautions that, if not applied, may lead to inconsistent results that depend on the procedural choices made in the analysis. In this work, taking neuroimaging studies on Autism Spectrum Disorders as a reference, it is demonstrated that the strong dependency of the cerebral quantities extracted with the segmentation software FreeSurfer 6.0 on the MRI acquisition parameters can, in a multivariate analysis based on ML, obscure the differences due to medical conditions and give inconsistent and meaningless results. |
| 777 | 15:33
|
Quantitative Mapping by Data-Driven Signal-Model Learning |
1Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 2Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, 3LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland |
||
In quantitative MRI, tissue properties are typically estimated by fitting a signal model onto the acquired data. These models are derived from the underlying MR physics describing the signal behavior. The accuracy of the quantitative values heavily depends on the correctness of this model which is usually validated using gold-standard sequences with long acquisition times. Here, we suggest learning the signal model based on the values obtained from the gold-standard sequence with machine learning methods instead. The feasibility of the idea is shown using quantitative T2-mapping with a multi-echo spin-echo sequence and a classical single spin-echo as the gold standard. |
15:45
|
Adjournment & Meet the Teachers |
Organizers: Arvind Pathak, Kannie WY Chan, Damian Tyler
| S01 | Wednesday 13:45 - 15:45 | Moderators: Arvind Pathak & Kannie WY Chan |
13:45
|
Technical Aspects of Biomarker Development & Application | |
1Massachusetts General Hospital, United States |
14:20
|
Clinical Translation & Utility of Biomarkers | |
1The University of Hong Kong, Hong Kong |
||
Molecular imaging biomarkers hold the promise to provideunparalleled opportunities for elucidating disease phenotypes, understanding pathophysiology, facilitating development of targeted therapies and driving personalised medicine. To realise the full potential of imaging biomarkers, our scientific community is compelled to translate them into clinical research and practice. This talk will present the current and emerging imaging biomarkers in clinical practice, including MRI and hybrid-PET imaging biomarkers, and describe the applications, strategies, opportunities and challenges in clinical translation. |
| 778 | 14:55
|
Tropoelastin: A novel marker for atherosclerotic plaque instability |
1Biomedical Engineering, King's College London, London, United Kingdom, 2Centre de Biophysique Moléculaire, CNRS, Orleans, France, 3Radiology, Pontificia Universidad Católica de Chile, Santiago, Chile, 4Academic Department of Vascular Surgery, King's College London, London, United Kingdom |
||
Elastolysis and ineffective |
| 779 | 15:05
|
Quantitative 3D Deuterium MRS Imaging of Glucose Metabolisms in the Rat Brain |
1Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States |
||
Assessment of metabolic coupling between glycolysis and oxidation is crucial for understanding neuroenergetics. Based on our recently developed in vivo Deuterium (2H) MR (DMR) spectroscopic approach, we further developed a quantitative DMR imaging method for simultaneous measuring the glucose consumption rate (CMRglc) and TCA cycle flux (VTCA) in rat brain at 16.4 T. Regional metabolic rates were quantified and compared between two brain conditions. The metabolite images were also generated. This work demonstrates the feasibility and reliability of in vivo DMR imaging for assessing glucose metabolisms, which makes it possible to image CMRglc and VTCA in brains under different states. |
| 780
|
15:15
|
Hyperpolarized 13C β-hydroxybutyrate/acetoacetate as a biomarker for non-invasive monitoring of NAD+/NADH status in glioblastoma |
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, United States |
||
Conversion of acetoacetate (AcAc) to β-hydroxybutyrate (β-HB) by the mitochondrial enzyme β-hydroxybutyrate dehydrogenase depends upon NADH availability. Previous studies have shown the potential of β-HB-to-AcAc ratio to reflect the redox state in rat hearts and lymphoma cells. Here, we assessed the value of HP [1,3-13C]-AcAc in brain. We demonstrated the potential to probe AcAc to β-HB conversion in normal mice and mice with glioblastoma. Significantly higher levels of [1-13C]-β-AcAc and [1-13C]-β-HB were observed in tumor-bearing mice compared to control mice. Consistent with lower levels of NADH measured in tumors, the [1-13C]-β-HB-to-[1-13C]-β-AcAc ratio trended towards a decrease compared to normal brain. |
| 781 | 15:25
|
CEST MRI detection of Deoxycytidine Kinase activity using natural deoxycytidine |
1Radiology, Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States |
||
To assess the activity of deoxycytidine kinase ( |
| 782 | 15:35
|
PET-MR multiparametric imaging biomarkers for differentiating between progression and radionecrosis of brain tumors |
1Neuroradiology, Pitié Salpêtrière Hospital, APHP, Paris, France, 2UMR S 1127, CNRS UMR 7225, ICM, UPMC Univ Paris 06, Paris, France, 3Centre de NeuroImagerie de Recherche – CENIR, ICM, Paris, France, 4Nuclear Medecine, Pitié Salpêtrière Hospital, APHP, Paris, France |
||
The aim of this work was evaluating the diagnostic accuracy of PET-MRI in difficult cases of differentiating between tumor progression and radionecrosis in neuro-oncology. For each lesion, PET (SUVmax, SUV mean, SUVpeak) and MRI (ADC, CBV, CBF, pCASL CBF) biomarkers were extracted. The combination of PET and MRI biomarkers allowed to improve the diagnostic accuracy. The logistic regression model has shown that 94% cases were correctly classified using the combination of SUVpeak and pCASL rCBF. Excellent diagnostic accuracy was achieved for both qualitative and quantitative evaluation by means of combined analysis of morphological, functional and metabolic imaging markers. |
15:45
|
Adjournment & Meet the Teachers |
| N03 | Wednesday 13:45 - 15:45 | Moderators: Alex MacKay & Se-Hong Oh |
| 783
|
13:45
|
Multidimensional T1 Relaxation-T2 Relaxation Correlation Spectroscopic Imaging (RR-CSI) for In Vivo Imaging of Microstructure |
1Electrical Engineering, University of Southern California, Los Angeles, CA, United States, 2Radiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, 3Cardiology, Massachusetts General Hospital, Boston, MA, United States |
||
We propose a new multidimensional MRI experiment called T1 Relaxation-T2 Relaxation Correlation Spectroscopic Imaging (RR-CSI) for probing microstructure. RR-CSI acquires imaging data with two-dimensional relaxation contrast encoding and estimates a high-dimensional spectroscopic image by using spatially-constrained reconstruction. The spectroscopic image comprises a full 2D T1-T2 spectrum at every voxel. The distinct peaks in these spectra correspond to different microscopic tissue compartments, which enables spatial mapping of microstructure. Compared to conventional methods, RR-CSI has improved capabilities for resolving tissue microenvironments with similar relaxation parameters. RR-CSI is demonstrated with real MRI data, including the first in vivo human brain results. |
| 784
|
13:57
|
Comparison of Inhomogeneous Magnetization Transfer and Myelin Water Fraction Ex-Vivo at 7T |
1Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 2UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 3International Collaboration on Repair Discoveries, Vancouver, BC, Canada, 4Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, 5Radiology, University of British Columbia, Vancouver, BC, Canada, 6Medicine, Division of Neurology, University of British Columbia, Vancouver, BC, Canada, 7Physics and Astronomy, McMaster University, Hamilton, ON, Canada, 8MR Clinical Science, Phillips Healthcare Canada, Markham, ON, Canada, 9ImageTech Lab, Faculty of Applied Sciences, Simon Fraser University, Surrey, BC, Canada |
||
Inhomogeneous magnetization transfer (ihMT) shows promise as a |
| 785
|
14:09
|
A Sequence for High Quality Gradient Echo Myelin Water Imaging (GRE-MWI) at 3T and 7T |
1Electrical Engineering and Computer Science, Seoul National University, Seoul, Republic of Korea, 2Biomedical Engineering, Hankuk University of Foreign Studies, Seoul, Republic of Korea, 3Division of Cerebral Integration, National Institute for Physiological Sciences, Okazaki, Japan, 4Department of Radiology, Seoul St.Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea |
||
In this study, we propose an eddy current compensated 2D GRE-MWI sequence and demonstrate that the sequence is robust to physiological noises. The resulting myelin water fraction maps at 3T and 7T shows high quality images at high resolution (2 × 2 × 2 mm3 at 3T and 1.5 × 1.5 × 2 mm3 at 7T). |
| 786
|
14:21
|
Whole brain inhomogeneous Magnetization Transfer (ihMT) imaging at 3T: concentrating RF power to mitigate RF inhomogeneities effects |
1Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 2BIDMC, Harvard Medical School, Boston, MA, United States, 3Phelma, INPG, Grenoble, France, 4Aix Marseille Univ, APHM, Hôpital de La Timone, Pôle d’Imagerie Médicale, CEMEREM, Marseille, France, 5Aix Marseille Univ, APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, APHM, Marseille, France |
||
Inhomogeneous magnetization transfer (ihMT) is a new MRI modality that provides strong sensitivity to myelinated tissues. Previously, a 3D whole brain ihMT sequence, based on GRE readouts interleaved with bursts of MT saturation pulses, was developed and optimized at 1.5T. In this work we demonstrate that concentrating the MT pulse energy can mitigate the sensitivity of ihMT to RF inhomogeneities encountered in high field systems. Overall, this allows for 1.5mm3 resolution ihMTR maps to be acquired at 3T, with a reduced B1-induced bias and strong signal within the whole brain, allowing robust clinical applications of ihMT at 3T. |
| 787 | 14:33
|
Towards short dipolar relaxation time, T1D, MRI |
1Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 2CNRS, CRMBM, UMR 7339, Aix Marseille Universite, Marseille, France |
||
The inhomogeneous magnetization transfer (ihMT) technique has shown myelin sensitivity, and is understood to be dependent on power and the dipolar relaxation time parameter, T1D, which is longer in myelinated tissues. Implementation of ihMT can be adapted to provide a smaller, but non-negligible signal from other, relatively short T1D tissues. Simulations showed a measurable ihMT signal, achieved from fixed low duty cycle MT preparations with high B1 pulses, decayed with pulse width at a rate dependent on T1D. Thus short, high B1 pulses were implemented to acquire ihMT data from ex-vivo samples of rat heart, kidney, and tail tendon, demonstrating the feasibility of short T1D imaging. |
| 788 | 14:45
|
MT-Based Detection of Semi-Solids without Background Water Signal. |
1AMRI, LFMI, NINDS, NIH, Bethesda, MD, United States |
||
Brain tissue can be modeled as a system with a water pool and an invisible pool of semi-solids. The exchange between these pools can be measured by saturating the semi-solids and observing the decrease in water signal after exchange. This requires making a differential measurement, comparing data with and without saturation. Here we present a variation of the STEAM sequence, adding water suppression, which allows for observation of exchanging spins in a single acquisition without a water background signal. The method was demonstrated in both a phantom and human subject at 3 T. |
| 789 | 14:57
|
Elliptical Magnetization Transfer: Calculating MT Parameters from the bSSFP Signal Ellipse |
1Neuroimaging, King's College London, London, United Kingdom, 2Biomedical Engineering, King's College London, London, United Kingdom |
||
Balanced Steady-State Free-Precession images are sensitive to T1, T2, off-resonance and Magnetization Transfer effects. Previously, Gloor et al extracted MT parameters from SSFP data, but required external T1 & B1 maps and did not account for off-resonance effects. Here we show that by incorporating the elliptical method of Shcherbakova et al, B0 can be measured and the need for an external T1 map removed. We present results covering the whole brain at 1.5mm isotropic voxel size acquired in 20 minutes. We also discuss an interesting asymmetry seen in the SSFP ellipse at low flip-angles. |
| 790 | 15:09
|
3D microscopy with CLARITY on human brain tissue: a tool for informing and validating MRI-based histology |
1Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany, 2Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 3Center for Cognitive Neuroscience Berlin, Free University Berlin, Berlin, Germany |
||
Recent developments of methods for mapping tissue microstructure with MRI require histological 3D data for validation. Here, CLARITY on post mortem human brain was adapted for this purpose. We demonstrated clearing of up to 8 mm thick samples, 3D microscopy of up to 5 mm thick samples, and the application of multiple stains including markers for neurons, glia, and fibers. The result is a detailed histology-based characterization of cyto- and myelo-architectonics within a volume corresponding to a typical MRI voxel. This approach promises to help integrate MRI-based histology and optical microscopy in 3D, and enable the further development and validation of in vivo histology using MRI. |
| 791
|
15:21
|
Disentangling the contributions of brain tissue fraction and composition to quantitative MRI |
1The Edmond and Lily Safra Center for Brain Science, The Hebrew University of Jerusalem, Jerusalem, Israel |
||
In-vivo quantitative MRI (qMRI) aims at characterizing the biological properties of brain tissue. However, qMRI parameters are sensitive both to the molecular tissue properties and to the water content within each voxel. We introduce a novel approach that disentangles these two contributions to qMRI parameters and provides tissue-specific measurements. This is achieved by evaluating the dependency of qMRI parameters on the non-water fraction. Using phantoms, we show that this dependency changes as a function of molecular composition. In the human brain, our method reveals unique tissue signatures for different brain regions, along with region-specific age-related changes. |
| 792 | 15:33
|
Longitudinal assessment of adolescent brain myelination using a pulsed magnetization transfer approach |
1Advanced MRI, LFMI, NINDS, NIH, Bethesda, MD, United States, 2Georgetown Center for Functional and Molecular Imaging, Washington, DC, United States, 3Program for Translational Research on Adversity and Neurodevelopment, The Pennsylvania State University, University Park, MD, United States |
||
The spatiotemporal growth trajectories of white matter, and in particular myelin, are an important part of cognitive development during adolescence. Quantitative magnetization transfer (qMT) imaging can be used to measure the fraction of non-water protons (fMT) as an estimate of myelin in vivo. Here we used a recently developed, time-efficient pulsed MT approach to extract fMT from white matter regions at different stages of development in a community-based cohort of adolescents. We tested the sensitivity of this approach for detecting region-specific change in fMT in repeated scans that covered a period of 18 months. |
| S02 | Wednesday 13:45 - 15:45 | Moderators: Hongyu An |
| 793
|
13:45
|
Quantitative T1 and T2 Brain Atlases for the Detection of Abnormal Relaxation Times |
1Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 2Biolab - Department of Electronics and Telecommunications, Polytechnic University of Turin, Turin, Italy, 3Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, 4LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 5Neuroimaging Laboratory and Neurology Department, Basel University Hospital, Basel, Switzerland, 6Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland |
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This work aims at the detection of abnormal relaxation times in the human brain. To that end, a pipeline for creating normative atlases was established. High-resolution atlases of normative T1 and T2 values were created based on mapping data from 52 healthy subjects. A regression model including gender and age was introduced and z-score maps calculated to compare T1 and T2 maps of a single-subject to the derived norms. Initial results based on multiple sclerosis patient data detect not only lesional tissue but also presumably altered normal-appearing white matter regions. |
| 794 | 13:57
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Assessment of the total iron mass using Quantitative Susceptibility Mapping (QSM): Deep gray matter iron depletion in multiple sclerosis? |
1Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, 2Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, United States, 3MR Research Laboratory, IRCCS, Don Gnocchi Foundation ONLUS, Milan, Italy, 4BairdMS Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States |
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It is often overlooked that iron concentrations, as determined, e.g., via Quantitative Susceptibility Mapping (QSM), reflect the mass of iron per unit volume. Consequently, structural atrophy alone (i.e. decreased volume) increases the tissue iron concentration if the total mass of iron remains constant. In this work, we present a technique to assess the mass of regional tissue iron in milligrams (mg). We retrospectively applied the technique to data from a recently published 2-year longitudinal study, in which we had investigated iron concentration changes in Multiple Sclerosis (MS). |
| 795 | 14:09
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MRI2MRI: A deep convolutional network that accurately transforms between brain MRI contrasts |
1Ophthalmology, The University of Washington, Seattle, WA, United States, 2eScience Institute, The University of Washington, Seattle, WA, United States |
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Different brain MRI contrasts represent different tissue properties and are sensitive to different artifacts. The relationship between different contrasts is therefore complex and nonlinear. We developed a deep convolutional network that learns the mapping between different MRI contrasts. Using a publicly available dataset, we demonstrate that this algorithm accurately transforms between T1- and T2-weighted images, proton density images, time-of-flight angiograms, and diffusion MRI images. We demonstrate that these transformed images can be used to improve spatial registration between MR images of different contrasts. |
| 796 | 14:21
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Absolute Cerebral Blood Flow Derived from Low GBCA Dose DCE-MRI in Patients with Type 2 Neurofibromatosis |
1Division of Informatics, Imaging and Data Science, University of Manchester, Manchester, United Kingdom, 2Department of Neurosurgery, Salford Royal NHS Foundation Trust, Manchester, United Kingdom |
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A newly developed low dose T1W-DCE-MRI method, ACcomb, was used to estimate the absolute CBF of vestibular schwannomas (VS) and normal appearing brain tissue in a group of 12 consecutive type 2 neurofibromatosis (NF2) patients, undergoing anti-angiogenic bevacizumab treatment. This new method consistently displayed excellent gray-white matter flow contrast and produced mean GM and WM CBF estimates consistent with previous literature values. Use of this new method showed that at 90 days post bevacizumab treatment, there was increased positive correlation between CBF and estimated plasma volume within the VS, and a significant increase in CBF within normal appearing white matter. |
| 797
|
14:33
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Comparison of the Tofts and the Shutter Speed Model for DCE-MRI in patients with Brain Glioma |
1Department of Surgery and Cancer, Imperial College London, London, United Kingdom, 2Department of Computer, Control and Management Engineering Antonio Ruberti, La Sapienza University of Rome, Rome, Italy, 3Department of Imaging, Imperial College Healthcare NHS Trust, London, United Kingdom, 4Department of Medicine, Imperial College London, London, United Kingdom, 5Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom |
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DCE-MRI allows interrogation of patho-physiological insular micro-environments through the passage of contrast agents and model-based pharmacokinetic analysis. In this study, we analysed data from 14 patients with suspected primary glioma who underwent DCE-MRI. Using both the Tofts model and the shutter speed model (SSM), we evaluated the performance and variability of each extracted parameter. We then analysed the ability of the two models to discriminate between tumour and healthy tissue to test the differences between the two methods. Results showed higher performance for the SSM, with a high robustness for the mean capillary water molecule lifetime τi. |
| 798
|
14:45
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Multicenter and multiscanner reproducibility of Magnetic Resonance Fingerprinting relaxometry in the brain |
1Siemens Healthcare GmbH, Erlangen, Germany, 2Max Schaldach-Stiftungsprofessur für Biomedizinische Technik, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 3Siemens Medical Solutions USA Inc., Malvern, PA, United States, 4Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 5Radiology, Case Western Reserve University, Cleveland, OH, United States |
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Magnetic Resonance Fingerprinting (MRF) is a technique for generating tissue property maps by matching pseudo randomly varying MR signal time courses in each voxel with a precalculated dictionary of possible evolutions. In this study, the repeatability of MRF results on the same scanner as well as the reproducibility on different scanners is evaluated for the human brain. |
| 799 | 14:57
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Consensus acquisition protocol for quantitative MRI of the cervical spinal cord at 3T |
1NeuroPoly Lab, Polytechnique Montreal, Montreal, QC, Canada, 2MR Clinical Science, Philips Healthcare, Gainesville, FL, United States, 3Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 4Brain MRI 3T Research Centre, C. Mondino National Neurological Institute, Pavia, Italy, 5Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 6Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 7Department of Surgery, University of Toronto, Toronto, ON, Canada, 8VisAGeS team, INRIA (INSERM, CNRS, Rennes 1 University), Rennes, France, 9Department of Radiology, Rennes University Hospital, Rennes, France, 10Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR 7339, CNRS Aix-Marseille Université, Marseille, France, 11Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 12Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 13Department of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD, United States, 14Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, United States, 15Department of Radiology, Northwestern Feinberg School of Medicine, Chicago, IL, United States, 16Biospective, Inc., Montreal, QC, Canada, 17Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom, 18Department of Neurology, University of California San Francisco, San Francisco, CA, United States, 19Department of Neurophysics, Max Planck Institute, Leipzig, Germany, 20Spinal Cord Injury Center Balgrist, Balgrist University Hospital, Zurich, Switzerland, 21Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, United Kingdom, 22Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, London, United Kingdom, 23Harvard-MGH Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 24Montreal Neurological Institute, McGill University, Montreal, QC, Canada, 25Functional Neuroimaging Unit, CRIUGM, University of Montreal, Montreal, QC, Canada |
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We present a consensus recommendation for best practices in high quality data acquisition of quantitative MRI (qMRI) of the cervical spinal cord at 3T. We propose protocols for computing cross-sectional area (CSA), magnetization transfer ratio (MTR) and diffusion tensor imaging (DTI) from three main vendors. We demonstrate these protocols by repeated scans of a single subject, from which the data and analysis scripts are made available. We hope harmonized and publicly-available spinal cord imaging protocols will promote reproducibility and thus accelerate the progress for spinal cord measurements to be more widely accepted as MRI biomarkers in multicenter studies. |
| 800 | 15:09
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Quantitative Magnetic Resonance Imaging of the Human Brain with White Matter Hyperintensities: a New Approach towards Understanding the Underlying Pathology |
1Institute of Neuroscience and Medicine - 4 (INM-4), Research Centre Juelich, Juelich, Germany, 2Institute of Neuroscience and Medicine - 1 (INM-1), Research Centre Juelich, Juelich, Germany, 3Georgian Technical University (GTU), Tbilisi, Georgia, 4Jülich Aachen Research Alliance (JARA), Juelich, Germany |
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The interest in white matter hyperintensities (WMHs) has increased recently as they have been associated with various clinical disorders such as stroke and dementia. Although postmortem histopathological studies reported various underlying pathophysiological mechanisms, in vivo studies have not been specific enough to conform those results. We attempted to fill this gap with quantitative MRI of water content, T1, T2*, and MT parameters. These parameters were analyzed for white and grey matter globally and for manually segmented WMHs. Based on the changes identified for WMHs and their trend with WMH load, we were able to complement histopathological findings. |
| 801 | 15:21
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Robust diffusion parametric mapping of motion-corrupted data using a deep-learning-based method |
1Center for Brain Imaging Science and Technology, Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, China, 2Department of Instrument Science & Technology, Zhejiang University, Hangzhou, China, 3MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China, 4Department of Imaging Sciences, University of Rochester, Rochester, NY, United States |
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Motion occurring during the acquisition of diffusion-weighted image volumes is inevitable. Deficient accuracy of volumetric realignment and within-volume movements cause the quality of diffusion model reconstruction to deteriorate, particularly for uncooperative subjects. Taking advantage of the strong inference ability of neural networks, we reconstructed diffusion parametric maps with remaining volumes after the motion-corrupted data removed. Compared to conventional model fitting, our method is minimally sensitive to motion effects and generates results comparable to the gold standard, with as few as eight volumes retained from the motion-contaminated data. This method shows great potential in exploiting some valuable but motion-corrupted DWI data. |
| 802 | 15:33
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Crosstalk of atrophic trigeminal nerve to abnormal brain structure in idiopathic trigeminal neuralgia |
1Department of Medical Imaging, First affiliated hospital of Xi'an Jiaotong University, Xi'an, China, 2Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Neural and Pain Sciences, School of Dentistry, University of Maryland Baltimore, Baltimore, MD, United States |
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Idiopathic trigeminal neuralgia (ITN) is characterized by intermittent, lancinating attacks in the branches of the trigeminal nerve (TGN). 40 ITN patients and 40 matched controls underwent MRI sessions and clinical pain assessment. TGN volume of cisternal segment and whole brain grey matter volume (GMV) were evaluated using voxel-based morphometry, ect. Reduced GMV was found in the insula, dorsal anterior cingulate cortex, precuneus, and several areas of the temporal lobe in ITN subjects. Correlation analysis revealed that decreased GMV of the left insula and decreased TGN volume were associated with increased pain ratings, providing new insight into pathophysiology of the disease. |
| S03 | Wednesday 13:45 - 15:45 | Moderators: Guanshu Liu |
| 803 | 13:45
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Glycerophosphocholine increase is a reliable surrogate marker of chemotherapy response for various cancer drug treatments in triple-negative breast cancer cells |
1Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States |
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MRS-detected total choline is a promising noninvasive surrogate marker of chemotherapy response in breast cancer. We have utilized six widely clinically used cancer chemotherapeutic drugs to treat triple-negative breast cancer cells to elucidate their molecular effects on choline phospholipid metabolism. We employed high-resolution 1H MRS to detect changes in cellular choline metabolites combined with molecular approaches. Glycerophosphocholine increased in triple-negative breast cancer cells following all six types of chemotherapeutic treatment compared to vehicle control, while phosphocholine decreased, increased, or remained stable depending on the specific drug used, making glycerophosphocholine the most reliable surrogate marker of chemotherapy response in our study. |
| 804 | 13:57
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Parametric Response Mapping of Normalized FLAIR MR Images Provides Early Indication of Recurrence Risk in Glioblastoma |
1University of Michigan, Ann Arbor, MI, United States, 2Radiology, University of Michigan, Ann Arbor, MI, United States, 3Grenoble Institut des Neurosciences, GIN, Universite Grenoble Alpes, Grenoble, France, 4Biostatistics, University of Michigan, Ann Arbor, MI, United States |
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Glioblastoma is a particularly malevolent disease, with median expected survival around 14 months. Standard protocols for treatment assessment and recurrence rely on morphological approximations of tumor burden. Recently included by the RANO criteria, T2/FLAIR is now standard in imaging protocols, highlighting edema, presumed to be associated with tumor cell infiltration and critical for accurate description of tumor burden and radiation treatment planning. Advanced methods for early detection of change are underutilized. Application of the Parametric Response Map technique provides greater sensitivity to FLAIR signal changes indicative of tumor progression prior to those detectable by morphological analysis alone. |
| 805
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14:09
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Dynamic contrast enhanced MRI detects pancreatic cancer responses to stroma-directed therapy |
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Pancreatic Cancer Research Center, University of Pennsylvania, Philadelphia, PA, United States, 3Abramson Cancer Center, University of Pennsylvania, philadelphia, PA, United States, 4Halozyme Therapeutics, San Diego, CA, United States |
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Stroma-targeted |
| 806
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14:21
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In vivo monitoring of intracellular pO2 in response to CAR T cell immunotherapy against glioma |
1Bioengineering, UCSD, La Jolla, CA, United States, 2Radiology, UCSD, La Jolla, CA, United States, 3Neurological Surgery, UCSF, San Francisco, CA, United States |
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We explore the temporal dynamics of tumor intracellular partial pressure of oxygen (pO2) in a murine glioma model receiving human chimeric antigen receptor (CAR) T cell immunotherapy. Tumor cells were intracellularly labeled with perfluoro-crown-ether (PCE) nanoemulsion ex vivo before flank injection in mouse. The spin-lattice relaxation rate (R1) of PCE is linearly proportional to the local oxygen concentration, enabling longitudinal in vivo measurement of absolute pO2 values. Our results indicate that CAR T cell therapy induces significant tumor pO2 increase peaking three days post-intravenous injection and correlates to tumor growth reduction. |
| 807 | 14:33
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Hyperpolarized-13C Imaging of Treatment Responses on Prostate Cancer Patients using 3D Dynamic CS-EPSI Techniques |
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, CA, United States, 3School of Medicine, University of California, San Francisco, San Francisco, CA, United States |
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Two unmet clinical needs facing the management of prostate cancer are to determine the best treatment for individual patients and to evaluate therapy response. In this study, we applied 3D dynamic imaging technique using hyperpolarized 13C nuclei to non-invasively probe prostate cancer metabolism. Pyruvate-to-lactate conversion kPL correlated well with biopsy and histological finding in pre-surgery prostate cancer patients. kPL values dramatically decreased in a patient 6 weeks into androgen-deprivation therapy with associated PSA decrease, indicating early treatment response. A non-responder patient with castration-resistant cancer exhibited high kPL one month after treatment that correlated with clinical progression. |
| 808 | 14:45
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Amide chemical exchange saturation transfer at 7T: A possible biomarker for detecting early response to neoadjuvant chemotherapy in breast cancer patients |
1Radiology, UMC Utrecht, Utrecht, Netherlands, 2Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 3Medical Oncology, Academic Medical Centre Amsterdam, Amsterdam, Netherlands, 4Pathology, UMC Utrecht, Utrecht, Netherlands |
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Neoadjuvant chemotherapy (NAC) has an important role in the treatment of breast cancer and the need for early detection of treatment response is high. Therefore we investigated the feasibility of using APT CEST at 7T as a biomarker for this purpose. Ten lesions were included and APT signal before and after the first cycle of NAC were correlated to the pathological response. Significant differences were found in APT signal corresponding with the pathological response. These results suggest that APT CEST may be used to predict the response to NAC treatment in an early stage. |
| 809 | 14:57
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Hyperpolarized 13C MRSI monitoring of response to HDAC inhibition in glioblastoma |
1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Physical Therapy and Rehabilitation Science/Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 3Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, United States, 4Neurological Surgery, University of California San Francisco, San Francisco, CA, United States |
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Treatment of glioblastoma (GBM) is comprised of maximum safe surgical resection, radiotherapy and chemotherapy with Temozolomide. Nonetheless, the median survival of GBM patients is only 15 months with five-year survival rate of only 5.5%. Vorinostat, the clinically relevant histone deacetylase (HDAC) inhibitor, is a novel drug that inhibits cell proliferation and induces apoptosis in solid tumors. Following Vorinostat treatment, we show a significant decrease in hyperpolarized [1-13C] lactate-to-pyruvate ratio that was associated with enhanced survival of glioblastoma-bearing mice. This highlights the potential of hyperpolarized 13C MRSI for monitoring response to a type of anticancer therapy previously unexplored in GBM patients. |
| 810
|
15:09
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Efficacy of oral CKD-516 in combination with sorafenib on hepatocellular carcinoma using MRI and optical imaging |
1Radiology, Asan medical Center, Seoul, Republic of Korea, 2GangNeung Asan Medical Center, Gangneung, Republic of Korea, 3Chong Kun Dang Research, Seoul, Republic of Korea, 4MR Core Laboratory, Asan medical Center, Seoul, Republic of Korea |
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We used an oral form of CKD-516 and designed a combination experiment with sorafenib. BLI tumor viability measurement showed CKD-516 was effective in combination with sorafenib, but there was only a slight improvement when treated alone. By MRI, the CKD-516 group showed notable intratumoral hemorrhage and central necrosis from the early stage of treatment. By IHC, CKD-516 was advantageous in collapsing blood vessels in tumor tissue, and was more effective when treated in combination with sorafenib. Therefore, oral CKD-516 was advantageous over sorafenib in terms of vascular disrupting ability, and combination of CKD-516 with sorafenib reduced the rebound phenomenon. |
| 811 | 15:21
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Effect of lonidamine on response to temozolomide in a human glioma model |
1University of Pennsylvania, Philadelphia, PA, United States, 2Thomas Jefferson University, Philadelphia, PA, United States, 3Regina Elena National Cancer Institute, IRCCS, Rome, Italy, 4University of Alabama, Birmingham, AL, United States |
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The treatment of glioblastoma multiforme (GBM) includes temozolomide (TMZ) chemotherapy concurrent with radiotherapy. Lonidamine (LND), an inhibitor of monocarboxylate transporters 1&4, the mitochondrial pyruvate carrier, and complex II, is shown here to potentiate TMZ-induced growth inhibition of U251 glioma cells. Through LC-Mass Spectrometry of cells and 31P and 1H MRS of U251 xenografts, we identified mechanisms of this potentiation, including tumor-selective inhibition of bioenergetics (βNTP/Pi) and simultaneous acidification (intracellular pH and lactate) which may inhibit enzymes contributing to TMZ resistance such as glutathione-S-transferase and O6-methylguanine DNA methyltransferase (MGMT). LND may improve the current care of glioma patients and potentially overcome TMZ resistance. |
| 812 | 15:33
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Evaluating Therapeutic Response of Glioblastoma (GBM) with Chemical Exchange Saturation Transfer (CEST) |
1Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 2Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 3Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada |
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Early assessment of glioblastoma (GBM) response to standard 6-week chemo-radiation enables changing or adjusting therapy in patients with progressive tumors. Chemical Exchange Saturation Transfer (CEST) probes the concentration and exchange of labile proteins and peptides in ht tumor and is more sensitive to treatment-induced effects. CEST was capable of differentiating progressors from non-progressors as early as two weeks into the treatment. Moreover, certain CEST metrics (i.e. MTRNOE, MTRAmide, CESTNOE) were capable of characterizing GBM aggressiveness even before the start of the treatment. |
| S04 | Wednesday 13:45 - 15:45 | Moderators: Jung-Ah Choi & Charles Hutchinson |
| 813
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13:45
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Elastography, T2-mapping, and Dixon MRI of the gluteus maximus muscle in spinal cord injured and able-bodied subjects |
1Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 2Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands, 3Radiology and Nuclear Medicine, Academic Medical Center, Amsterdam, Netherlands, 4Reade, Centre for Rehabilitation and Rheumatology, Amsterdam, Netherlands, 5Center for Extreme Bionics, Media lab, MIT, Cambridge, MA, United States, 6Department of Rehabilitation, Academic Medical Center, Amsterdam Movement Sciences, Amsterdam, Netherlands, 7Image Sciences & Biomedical Engineering, King’s College London, London, United Kingdom, 8Human Movement Sciences, VU University, Amsterdam, Netherlands |
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Gluteus maximus biomechanical properties and composition are altered in spinal cord injured (SCI) subjects and increase the risk of deep tissue injury type of pressure ulcers. For this purpose, a multi-parametric MRI study of the gluteus maximus of SCI and able-bodied subjects was performed. The protocol consisted of MRE, T2-mapping, and Dixon. The gluteus maximus of SCI subjects had a lower stiffness, which was accompanied by a higher fat fraction, as compared to the able-bodied subjects. The proposed protocol has great potential in providing personalized information on deep tissue injury risk. |
| 814 | 13:57
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3D-T1rho mapping of upper arm muscles in post-stroke patients |
1Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States, 2Rusk Rehabilitation, New York University School of Medicine, New York, NY, United States |
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In this study, we evaluate the use of 3D-T1rho (T1ρ) relaxation mapping of the upper arm muscle glycosaminoglycan (GAG) content in healthy controls, and post stroke patients with pre and post hyaluronidase injections. Healthy controls (n=5) and post-stroke patients (n=5, pre and post treatment) were recruited. Dixon based water-fat imaging and T1ρ mapping were performed. Mono- and bi-exponential modeling was used to process the data. While water-fat distributions were not significantly different between the two groups, significant differences were noted in T1ρ values using mono- and bi-exponential analysis. T1ρ imaging shows significant changes that reflect the reduction of GAG’s following the treatment with hyaluronidase injection. |
| 815
|
14:09
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Water T2 mapping in fatty infiltrated thigh muscles of patients with neuromuscular diseases using a T2-prepared 3D TSE with SPAIR |
1Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany, 2Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, Munich, Germany, 3Friedrich-Baur-Institut, Ludwig Maximilian University, Munich, Germany, 4Department of Neurology, Technical University of Munich, Munich, Germany |
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In patients with neuromuscular diseases muscle water T2 is an important biomarker to monitor disease activity and therapy effectiveness. Especially, the thigh is of interest showing disease-characteristic patterns of involvement. Different T2 mapping approaches, routinely based on MESE, have been developed to minimize the effect of confounding factors. An alternative method is the T2Prep 3D-TSE combined with SPAIR. However, it remains unknown, how T2Prep 3D-TSE performs in the presence of fat. This work simulates the effect of SPAIR and T2preparation on the 3D-TSE readout in the presence of fat and compares T2Prep 3D-TSE and 2D-MESE to MRS in 34 patients. |
| 816
|
14:21
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Multi-parametric MR shows increased T2 heterogeneity in fat infiltrated muscles in Becker Muscular Dystrophy |
1Radiology, Amsterdam Medical Center, Amsterdam, Netherlands, 2Radiology; C.J. Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands, 3Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 4Neurology, Leiden University Medical Center, Leiden, Netherlands |
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Quantitative MR is increasingly used to assess muscle damage in muscular dystrophies, including BMD. Early markers that reflect changes in muscle tissue are becoming increasingly important with therapies aimed at preserving muscle tissue. This study used a multi-modal MR approach to examine diffusion properties, the average water T2 and SD of the water T2 in non-fat-infiltrated and fat-infiltrated muscles in BMD. Our results indicate that none of the proposed measures are sensitive to muscle tissue changes prior to the replacement of muscle tissue by fat and that only T2 heterogeneity is sensitive to muscle tissue changes in the presence of fat in patients with BMD. |
| 817
|
14:33
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Increased T1Rho relaxation in a Duchenne muscular dystrophy mouse model with increased muscle fibrosis |
1Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Human Genetics, Leiden University Medical Center, Leiden, Netherlands, 3Preclinical and Translational MRI, Academic Medical Center, Amsterdam, Netherlands |
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A T1Rho sequence was used in a Duchenne Muscular Dystrophy mouse model characterized by increased muscle fibrosis. Significantly higher T1Rho relaxation times were found compared to wild-type mice in which fibrosis was absent. Although both T1Rho and T2 values were increased, the increase was more pronounced for T1Rho than for T2 (14.2% vs 3.6%), indicating that T1Rho is affected by other processes than those resulting in increased T2 values. These data demonstrate the potential of T1Rho to assess muscle fibrosis in vivo. |
| 818 | 14:45
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Quantification of water T1 and fat fraction in skeletal muscle tissue using an optimal MR fingerprinting radial sequence (MRF-WF) |
1NMR Laboratory, Institute of Myology, Paris, France, 2NMR Laboratory, CEA, DRF, IBFJ, MIRCen, Paris, France |
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Quantitative T1-mapping might represent an efficient tool to monitor inflammation, necrosis or fibrosis processes in skeletal muscle tissues affected by neuromuscular disorders. However, standard T1-mapping sequences cannot separate the contribution of water and fat protons. If directly applied to fatty infiltrated skeletal muscles, a “global” T1 value would mainly reflect the degree of intramuscular fat and the other underlying processes would largely be hidden. Here, we proposed an optimal sequence allowing simultaneous estimation of water T1 and fat fraction. It was validated in phantom and in vivo acquisitions were performed on several subjects suffering from different neuromuscular diseases. |
| 819 | 14:57
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Quantitative T2 mapping of the thigh muscles and its correlation with the ADC: a feasibility study in assessing inflammatory myopathy |
1Radiology, Peking Union Medical College Hospital, Beijing, China, 2Rheumatology, Peking Union Medical College Hospital, Beijing, China, 3Advanced Clinical Imaging Technology, Siemens Healthcare, AG, Switzerland, 4MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China |
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We investigated the use of the T2 mapping technique to quantitatively evaluate the thigh muscles of 18 dermatomyositis (DM)/polymyositis (PM) patients and 10 healthy control subjects. Moreover, the correlation of T2 values with apparent diffusion coefficient (ADC) values was also studied. The results showed significantly elevated T2 values with edematous muscles and increased T2 values with unaffected muscles (normal appearing in conventional MRI) in DM/PM patients, compared to the control group. The T2 values of the edematous muscles were found to be closely correlated with the ADC. This study demonstrated that T2 mapping may be successfully used in the quantitative evaluation of inflammatory myopathy. |
| 820 | 15:09
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Magnetic resonance measurements of fat content and water diffusion in muscles of glucocorticoid-treated patients with polymyalgia rheumatica compared with healthy volunteers. |
1NIHR Musculoskeletal Biomedical Research Centre, Leeds, United Kingdom, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, 3Siemens Healthcare GmbH, Erlangen, Germany, 4School of Human and Health Science, University of Huddersfield, Huddersfield, United Kingdom, 5School of Medicine, University of Leeds, Leeds, United Kingdom |
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The purpose of this study was to assess differences in fat fraction and water diffusion between muscles in the healthy thigh and to assess differences between glucocorticoid treated patients with polymyalgia rheumatic (PMR) and healthy controls. Twenty five healthy volunteers and sixteen patients with PMR undergoing glucocorticoid treatment underwent MRI to assess muscle fat fraction and diffusion. The study found that the hamstrings have greater fat fraction and reduced diffusion compared to quadriceps in healthy individuals. Furthermore, alterations in fat fraction and diffusion parameters associated with glucocorticoid-treated PMR are more readily detectable in the hamstrings than the quadriceps. |
| 821
|
15:21
|
Both oxygen supply and phosphocreatine recovery rate show proximo-distal gradients along the human tibialis anterior after exercise |
1Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, 2Geriatrics, Radboud university medical center, Nijmegen, Netherlands |
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Since the rate of phosphocreatine recovery after exercise varied substantially within the tibialis anterior, we wondered if O2 supply also varied along this muscle. Therefore, we applied near infra-red spectroscopy to study the dynamic equilibrium of O2 supply and O2 utilization, intravoxel incoherent motion imaging for muscle perfusion and 31P-MRS during and after isometric exercise of the tibialis anterior. We observed higher post-exercise perfusion and faster phosphocreatine and oxyhemoglobin recovery proximally than distally in the tibialis anterior, indicating a proximo-distal gradient in O2 supply. This may be an adaptation to a higher proximal energy requirement. |
| 822 | 15:33
|
Work dependence of calf muscle DTI exercise response from dynamic imaging |
1Bernard and Irene Schwartz Center for Biomedical Imaging, NYU Langone Medical Center, New York, NY, United States, 2Center for Advanced Imaging and Innovation (CAI2R), NYU Langone Medical Center, New York, NY, United States, 3Department of Radiology, NYU Langone Medical Center, New York, NY, United States |
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We describe measurement of work dependence of exercise response of diffusion contrast in calf muscle with a multiple echo diffusion tensor imaging (MEDITI) in a clinical 3 T scanner. With radial imaging, accelerated diffusion encoding, and compressed sensing reconstruction, spatial resolution of 3.7 mm and temporal resolution of 16 s was achieved. Using an MR-compatible ergometer with pneumatic resistance and force/displacement monitoring, post-exercise recovery of T2 and DTI metrics following plantarflexion in gastrocnemius muscle were monitored as a function of total normalized work. Exercise response showed significant anisotropy, and trends of higher response with work were observed. |
| S05 | Wednesday 13:45 - 15:45 |
| 823 | 13:45
|
MR elastography and multiparametric MRI of chronic pancreatitis reversal after bariatric surgery in obese rats |
1UMR 1149 Center For Research on Inflammation, Inserm, Paris, France, 2Beaujon Hospital, Pancreatology, AP-HP, Clichy, France, 3Beaujon Hospital, Pathology, AP-HP, Clichy, France, 4Bichat Hospital, Pathology, AP-HP, Paris, France, 5Beaujon Hospital, Radiology, AP-HP, Clichy, France |
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In obesity, pancreas is affected by fatty infiltration and fibrosis. Bariatric surgery is one of the only therapies which demonstrably improves pancreas status in obesity. In the present work we investigated the mechanical properties at several frequencies, the PDFF and the T2* of pancreatic explants in an obese rat model of bariatric surgery. Bariatric surgery reversed the MRI parameters to values not significantly different than controls. MRI parameters closely matched the reference histology observations. MRE and multiparametric MRI may be used to monitor pancreatic status and treatment response in an obese rat model of bariatric surgery. |
| 824 | 13:57
|
T1 Mapping and MR Elastography (MRE) for the Diagnosis of Mild Chronic Pancreatitis |
1Shengjing Hospital of China Medical University, Shen Yang, China, 2Philips Healthcare, Beijing, China |
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We have investigated the value of both MR elastography (MRE) and T1 mapping for early detection of Mild Chronic pancreatitis(CP). Our study found that both MRE and T1 mapping had good diagnostic performance for detecting mild CP, with MRE slightly outperforming T1 mapping. |
| 825 | 14:09
|
Differentiation of Mass-forming Focal Pancreatitis (MFFP) from Pancreatic Cancer (CP): Added Value of Magnetic Resonance Elastography (MRE) to Dynamic Contrast-enhanced Magnetic Resonance Imaging (DCE-MRI) |
1Shengjing Hospital of China Medical University, ShenYang, China, 2Philips Healthcare China, Beijing, China |
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The differential diagnosis of mass-forming focal pancreatitis (MFFP) and pancreatic cancer (PC) is clinically important. Our study shows that combined assessment of magnetic resonance elastography (MRE) with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a promising technique with improved specificity of diagnosing PC from MFFP cases, when comparing with DCE-MRI. |
| 826 | 14:21
|
T1 mapping of the pancreas: correlation with HbA1c values |
1Gifu University, Gifu, Japan, 2Kyoto Prefectural University of Medicine, Kyoto, Japan, 3Philips Healthcare, Tokyo, Japan |
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The presence of pancreatic fibrosis is a representative feature of the pancreas in patients with impaired glucose tolerance (IGT). The T1 signal intensity of the pancreas is reported to be associated with pancreatic fibrosis and HbA1c values. In this study, we evaluated the feasibility of T1 mapping of the pancreas for the assessment of HbA1c values. Our results showed that increased T1 values of the pancreas was significantly correlated with HbA1c values, so the T1 values of the pancreas could serve as a potential imaging biomarker for the assessment of patients with IGT. |
| 827 | 14:33
|
Pancreas perfusion and transit-time measurement using pseudo-continuous ASL |
1Division of MRI Research, department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 2Global MR Applications and Workflow, GE Healthcare, Boston, MA, United States |
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While there are strong interests in non-contrast pancreatic perfusion measurement, reports of ASL use for this purpose are rare due to several challenges. In this work, we investigate the robustness of background-suppressed-pCASL for pancreatic perfusion, with an emphasis on quantifying blood-flow (PBF) and transit-time (ATT) using multiple-delays ASL. Robust ASL signal was obtained in all volunteers, and ATT was measured to be 1029±89ms. Measured ATT-corrected PBF was 162±12mL/100g.min. Evidence of heterogeneity in ATT and PBF was found, potentially linked to the complex vascular supply and different exocrine/endocrine functions. Hence, pCASL PBF measurement is feasible and holds promise for clinical studies. |
| 828 | 14:45
|
Comparison of T2WI and DWI qualitative assessment and T2W-based radiomic features for predicting complete response in patients with rectal cancer after neoadjuvant chemoradiotherapy |
1Memorial Sloan Kettering Cancer Center, New York, NY, United States |
||
Radiomics is a novel science that encompasses a computer-based extraction of quantitative features from images. Some studies have demonstrated that radiomics may help distinguishing malignant from benign diseases. We hypothesize that radiomics extracted from T2WI may improve qualitative MRI assessment in the evaluating of complete response in patient with locally advanced rectal cancer after neoadjuvant chemoradiotherapy. |
| 829 | 14:57
|
Machine Learning for Prediction of Chemoradiation Therapy Response in Patients with Locally-Advanced Rectal Cancer (LARC) Using Pre- and Early-Treatment Follow-up Multiparametric MRI |
1Department of Radiological Sciences, University of California, Irvine, CA, United States, 2Department of Radiation Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China, 3Department of Radiation Oncology, Rutgers-The State University of New Jersey, New Brunswick, NJ, United States, 4Department of Radiology, University of California, San Francisco, CA, United States |
||
A convolutional neural network (CNN) was implemented to predict the response of LARC patients receiving neoadjuvant chemoradiation therapy. The pre-treatment MRI, and the early-treatment follow-up MRI done at 2-3 weeks after the initiation of radiation were used. The MRI protocol included T2, DWI and DCE. A total of 41 patients were studied, with 8 pCR, 27 Tumor Regression Grade 1, and 9 TRG 2+3. The prediction accuracy was 0.71-0.89 for pCR vs. non-pCR; 0.70-0.77 for TRG(0+1) vs. TRG(2+3), not very good due to the limitations of a relatively small dataset. Using manually extracted tumor features in conjunction with neural network classifiers may achieve a higher accuracy. |
| 830 | 15:09
|
Multiparametric evaluation of inflammation and fibrosis in a radiation-induced murine model of colitis |
1Laboratory of Imaging Biomarkers, CRI-UMR1149, Inserm, Paris, France, 2Laboratory of Intestinal Inflammation, CRI-UMR1149, Inserm, Paris, France, 3Department of Radiology, Beaujon University Hospital, Clichy, France, 4Department of Pathology, Beaujon University Hospital, Clichy, France, 5Research Laboratory in Radiobiology and Radiopathology, IRSN, Fontenay-aux-Roses, France |
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The evaluation of fibrosis severity in Crohn’s disease is essential for patient management and prognosis, albeit seldom investigated. We validated a MR approach including diffusion-weighted imaging, magnetization transfer and FAIR perfusion to distinguish between moderate and severe forms of fibrosis in a radiation-induced murine model of colitis. The presence of fibrotic tissue and its accompanying vascular alterations induced a decrease in apparent diffusion coefficient and in perfusion, and an increase in the magnetization transfer ratio. This approach could be applied for diagnosis and assessment of intestinal fibrosis in patients. |
| 831 | 15:21
|
MRI predicts histopathologic composition of ileal Crohn's disease. |
1Radiology, Pitié Salpêtrière Hospital, UPMC, Paris, France, 2Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, 3Pathology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, 4Radiology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, 5Gastroenterology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States |
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The aim of our study was to assess the value of MRI for the characterization of histopathologic tissue composition of small bowel Crohn’s disease (CD), including assessment of inflammation, fibrosis and smooth muscle hypertrophy. Our results showed that MRI-based parameters including ADC, MaRIA score and layered pattern of enhancement can predict the degree of bowel inflammation. We also showed that wall thickness measured on T2WI can distinguish prominent muscle hypertrophy from prominent fibrosis in ileal CD. |
| 832 | 15:33
|
MRI of whole gut transit time in newly diagnosed coeliac disease. |
1Nottingham Digestive Diseases Centre and NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, United Kingdom, 2Medical Physics and Clinical Engineering, Nottingham University Hospitals, Queen’s Medical Centre, Nottingham, United Kingdom, 3Nottingham NHS Treatment Centre, Nottingham University Hospitals, Queen's Medical Centre Campus, Nottingham, United Kingdom, 4Department of Medicine and Surgery, Scuola Medica Salernitana Università di Salerno, Salerno, Italy |
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Coeliac disease (CD) is an autoimmune disease which affects 1 in 100 people. There is no cure and the only treatment is a lifelong gluten free diet. This study aims to improve our understanding of the functional motility disorder associated with CD using MRI. Whole gut transit time (WGTT), measured using MRI transit markers, was significantly delayed in the coeliac patients compared to helathy controls (p<0.04). The MRI gut transit test is quick and is acceptable to patients and could help long term monitoring and follow up, complementing existing more invasive techniques. |
| S06 | Wednesday 13:45 - 15:45 | Moderators: Jason Stockmann & Anke Henning |
| 833
|
13:45
|
Dynamic B0 Shimming for Multi-Slice Metabolite Mapping at Ultra-High Field in the Human Brain: Very High Order Spherical Harmonics vs. Multi-Coil |
1Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2IMPRS for Cognitive and Systems Neuroscience, Eberhard-Karls University of Tuebingen, Tuebingen, Germany, 3Department of Biomedical Magnetic Resonance, Eberhard-Karls University of Tuebingen, Tuebingen, Germany, 4Department of Physics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany |
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In this work, we evaluated the performance of two B0 shimming approaches (i.e. a very high order spherical harmonic shim system versus a multi-coil shim setup), for dynamic shimming in the context of high resolution and multi-slice metabolite mapping of the human brain at 9.4T. |
| 834
|
13:57
|
Integrated ΔB0/Rx coil array for improved spinal cord imaging at 3T |
1NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 2École polytechnique fédérale de Lausanne, Lausanne, Switzerland, 3Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 4A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 5Harvard Medical School, Boston, MA, United States, 6Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada |
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Spinal cord imaging is hampered by static and respiration-induced dynamic variations of B0, causing serious issues for EPI-based protocols and spectroscopy. Integrated ΔB0/Rx arrays could provide an effective means to further compensate small-scale variations, complementary to the existing spherical harmonic coils. Here, we designed, built and tested in a human subject an 8-channel integrated ΔB0/Rx coil for the cervical spinal cord. Results showed improvements for correcting static field variations as well as respiratory-induced variations. Future studies will investigate dynamic and real time shimming applications for the spinal cord. |
| 835 | 14:09
|
Regularized Second-order Dynamic Shimming |
1Wellcome Centre for Integrative Neuroimaging, FMRIB, University of Oxford, Oxford, United Kingdom |
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The implementation of dynamic shimming relies on determining robust and accurate shim currents. This work presents a novel, analytical, and fully automated regularized shim determination technique to solve ill-conditioned least-square problems and regularize current constraint challenges for dynamic shimming applications. The method is based on the Tikhonov regularization whereby the L-curve method is utilized to search for an optimal shim solution. The method improves shim current use efficiency and conditioning of the shim determination problem, outperforming the truncated singular value decomposition regularization based least-square method. |
| 836
|
14:21
|
Inter-slice current constrained B0 shim optimization for high order dynamic shim updating with strongly reduced eddy currents |
1Institute of Neuroscience and Medicine, Medical Imaging Physics (INM-4), Forschungszentrum Jülich, Jülich, Germany, 2Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 3Faculty of Medicine, Department of Neurology, RWTH Aachen University, Aachen, Germany |
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Dynamic shim updating using spherical harmonics is an effective B0 shim technique, but known to induce eddy currents which degrades the achievable shim quality. Current DSU implementations therefore use pre-emphasis which requires additional hardware and time-consuming system calibrations. To reduce eddy current generation, we have implemented an optimization algorithm which limits the maximum inter-slice shim current change. It is based on the assumption that a smooth variation of shim currents with small current steps will substantially reduce eddy currents. Simulations and initial experiments have shown that eddy currents can be drastically reduced without significant impact on the achievable shim quality. |
| 837 | 14:33
|
The orthogonal shim coil at 3-Tesla |
1High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2Graduate Training Center of Neuroscience, IMPRS, University of Tübingen, Tübingen, Germany, 3A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 4Harvard Medical School, Boston, MA, United States, 5Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 6Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, 7Department of Neuroscience and Biomedical Engineering, Alto University, Espoo, Finland |
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We purpose an integrated RF-shim coil array, where the shimming current path and the RF receiving coil are arranged |
| 838
|
14:45
|
Application of Integrated Parallel Reception, Excitation, and Shimming (iPRES) for Signal Loss Recovery in fMRI |
1Brain Imaging and Analysis Center, Duke University, Durham, NC, United States, 2Medical Physics Graduate Program, Duke University, Durham, NC, United States |
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Integrated parallel reception, excitation, and shimming (iPRES) coil arrays enable simultaneous image acquisition and localized B0 shimming with a single coil array. We propose to apply this novel technology to recover signal loss in fMRI by using a new shim optimization algorithm. Simulations and in vivo experiments performed with a 32-channel iPRES head coil array demonstrate that the proposed method can reduce both the B0 inhomogeneity and the signal loss in gradient-echo EPI images, particularly in the inferior frontal brain region, resulting in more activation in that region in a breath-holding fMRI experiment. |
| 839 | 14:57
|
MAGNUS: An ultra-high efficiency head-only gradient coil for imaging the brain microstructure |
1GE Global Research, Niskayuna, NY, United States, 2GE Healthcare, Florence, SC, United States, 3Uniformed Services University of the Health Sciences, Bethesda, MD, United States, 4Ft. Belvoir Community Hospital, Ft. Belvoir, VA, United States |
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An ultra-high gain asymmetric gradient coil design for imaging the brain microstructure is described. This design has greater than 4 times the gain of existing whole-body gradient coils and 3x that of the Compact 3T gradient coil with similar inner diameter. With a 1 MVA driver, this gradient coil is designed to deliver 200 mT/m at a maximum slew rate of 500 T/m/s. |
| 840 | 15:09
|
Constrained Optimization for Static and Dynamic B0 Shimming |
1MRRC, Dept. of Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 2Medical Imaging Physics (INM-4), Institute of Neuroscience and Medicine, Jülich, Germany |
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Dynamic shimming compared to global shimming improves B0 homogeneity over whole brain. However, typical shim optimization could result in high currents, particularly for small volume, e.g. small slab or slice. To address this we investigated the extent to which large reductions in aggregate shim current could be achieved through constrained optimization at 7T. We also investigated the extent to which alternate imaging orientation could improve homogeneity. The results show constrained optimization can provide robust shimming at substantially reduced aggregate current values, and angulated imaging improved shimming condition. The proposed methods enhanced multi-slice imaging by reducing both susceptibility-induced signal losses and distortions. |
| 841 | 15:21
|
Towards Real-time MRI Guided Cancer Therapy: Development of a high field Inline MRI-Linac |
1Ingham Institute, Liverpool, Australia, 2Liverpool Cancer Therapy Centre, Liverpool, Australia, 3University of Queensland, Brisbane, Australia, 4University of Sydney, Sydney, Australia |
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This study describes the progress that has been made using a dedicated split bore 1.0 Tesla magnet to provide an MRI-guided radiotherapy system. This magnet design has a number of advantages including patient entry in two orientations to investigate competing magnetic field-beam configurations. A number of beam and imaging experiments, including first in vivo results, are described which show the efficacy of the system as an integrated inline MRI-Linac. |
| 842 | 15:33
|
Integrated Parallel Reception, Excitation, and Shimming (iPRES) Breast Coil Array for Simultaneous MR Image Acquisition and Localized B0 Shimming |
1Brain Imaging and Analysis Center, Duke University, Durham, NC, United States, 2Medical Physics Graduate Program, Duke University, Durham, NC, United States, 3Medical Physics Graduate Program, Duke Kunshan University, Kunshan, China, 4GE Healthcare, Aurora, OH, United States |
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In breast imaging, the image quality is severely degraded by susceptibility-induced B0 inhomogeneities. Here, we apply the novel integrated parallel reception, excitation, and shimming (iPRES) technology to enable simultaneous image acquisition and localized B0 shimming of the breasts with the same coil array. Proof-of-concept in vivo experiments with only four iPRES(1) breast coil elements already show up to 43.3% reduction in B0 root-mean-square error with no SNR compromise. Simulations show that the shimming can be further improved by implementing more complex iPRES(N) geometries with N smaller shim loops per RF coil element. |
| W03/04 | Wednesday 13:45 - 15:45 | Moderators: Nadine Girard & Sean Deoni |
| 843 | 13:45
|
Fixel-based analysis of white matter fibre density and morphology in the preterm brain. |
1Centre for the Developing Brain, King's College London, London, United Kingdom, 2Centre for Medical Image Computing, University College London, London, United Kingdom |
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Fixel-based analysis (FBA) provides measures of fibre cross-section (FC) and fibre density (FD) for individual fibre populations within voxels containing crossing fibres, overcoming the limitations of the diffusion tensor model. FBA was applied to a preterm neonatal cohort to assess the effects of perinatal risk factors on white matter, identifying decreases in FD and FC in distinct fibre populations associated with increased prematurity, low birthweight, respiratory support and parenteral nutrition. We show that aberrant white matter development previously attributed to microstructural changes may be related to alterations in the cross-sectional area of specific fibre bundles at the macroscopic scale. |
| 844 | 13:57
|
Caffeine and brain development in preterm children |
1Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia, 2Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia, 3Department of Neurosurgery, The Royal Children's Hospital, Melbourne, Australia, 4Neuroscience research, Murdoch Children's Research Institute, Melbourne, Australia, 5Department of Medicine, Monash Medical Centre, Monash University, Melbourne, Australia, 6Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Australia, 7Department of Paediatrics, The University of Melbourne, Melbourne, Australia, 8Newborn research, The Royal Women's Hospital, Melbourne, Australia, 9Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia, 10Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, Australia, 11Florey Institute of Neuroscience and Mental Health, Melbourne, Australia |
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We investigated effects of neonatal caffeine treatment on brain structure and longitudinal development in a subset of preterm children from a randomized, placebo-controlled trial. Children had MRI at age 11 years (n=118; 64 received caffeine, 54 received placebo), of whom 43 (21 caffeine, 22 placebo) had MRI at term-equivalent age. Global and regional brain volumes, cortical morphometry and white matter microstructure were similar between treatment groups at age 11 years, as was brain development from term-equivalent age to 11 years of age. Any benefits of caffeine on brain structure weaken over time and were not apparent at age 11 years. |
| 845 | 14:09
|
Early postnatal music intervention in preterm birth reorganizes salience network interactions |
1Division of Development and Growth, Department of Pediatrics, University of Geneva, Geneva, Switzerland, 2Institute of mathematics, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 3Neuroscience of Emotion and Affective Dynamics Lab, Department of psychology and educational sciences, University of Geneva, Geneva, Switzerland, 44 Swiss center for affective neurosciences, University of Geneva, Geneva, Switzerland, 5Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland, 6Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland |
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The aim of this study is to characterize the preterm brain functional connectivity and to test the effectiveness of an early postnatal music intervention on preterm newborn’s functional brain development. We explored functional connectivity by resting state fMRI in 16 full-term 1 to 4 days old newborns and 29 preterm infants (born < 32weeks) at term equivalent age (TEA) randomly assigned to either music intervention (14 newborns) or control group. We identified a network of interest that represents resting state functional connectivity decrease in preterm control compared to full-term newborns. We found salience network functional connectivity to be especially altered by a premature birth but music intervention significantly increased its connectivity. To the best of our knowledge, this study is the first one to observe music effects on brain development in the preterm newborns. |
| 846
|
14:21
|
Cortical microstructures at birth predict neurodevelopmental outcome at 2 years of age |
1Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 2Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States |
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Cortical microstructural architecture in preterm brain, quantitatively delineated with DTI fractional anisotropy (FA), is characterized by various levels of dendritic arborization. With cortical FA an important indicator of |
| 847 | 14:33
|
Connectome of the Extremely Preterm Brain at Adolescence and Measures of Cognitive Functioning: Early Experience with White Matter Fibrography (WMF) |
1Boston University, Boston, MA, United States, 2University of North Carolina Children’s Hospital, Chapel Hill, NC, United States |
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Purpose: To analyze the fiber bundle architecture via white matter connectomes of extremely preterm (EP) born adolescents generated by Synthetic-MRI based white matter fibrography, and to study associations with summary measures of intelligence quotient (IQ) and executive function (EF). Methods: Eleven EP adolescents were scanned the tri-turbo spin echo pulse sequence, which is the concatenation of dual-echo TSE and single-echo TSE pulse sequences, both acquired with same geometry and scanner settings. Results: Connectome were successfully created for all subjects. Conclusion: White matter fibrography is a direct and reliable method for generating whole-brain white matter connectomes in adolescents born EP, and appears to have clinical relevance. |
| 848 | 14:45
|
Long term Brain Functional Connectivity changes after Neonatal Arterial Ischemic Stroke (NAIS): A resting state fMRI study |
1Institute Joliot/DRF/CEA, U1129/UNIACT, Neurospin, CEA-Saclay, Gif sur Yvette, France, 2Département de SSR pédiatrique, CHU Angers, Angers, France, 3Institute Joliot/DRF/CEA, UNATI, Neurospin, CEA-Saclay, Gif sur Yvette, France, 4Departement de Rééducation Fonctionnelle, CHU Saint Etienne, Saint Etienne, France, 5University Hospital Necker-Enfants Malades, Paris, France, 6CHU Lille, Lille, France |
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Resting state fMRI enables the study of plastic inter- and intra- hemispheric connectivity changes after early brain lesions. We studied 38 7yo children having suffered an arterial ischemic stroke in the neonatal period (NAIS) and 29 age-matched controls, with rs-fMRI, and language fMRI. Preprocessing took into account various sources of spurious signals (motion, lesion, interdependency of correlation measures, etc…). Tangent metric appeared the most accurate to classify groups of subjects and highlighted mostly a reduced inter-hemispheric connectivity in the auditory, language, and attentional networks, especially in patients with atypical clinical or fMRI language profiles, but with little evidence for intra-hemispheric changes. |
| 849
|
14:57
|
Macroscopic Hyperdynamic CSF and Ciliary Motion Dysfunction Predict Executive Dysfunction in Children and Adolescents with Congenital Heart Disease |
1Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 2Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, 3Pediatrics Internal Medicine, Children's Hospital of Pittsburgh UPMC, Pittsburgh, PA, United States, 4Developmental Biology, University of Pittsburgh, Pittsburgh, PA, United States, 5Department of Physical Medicine & Rehabilitation, Children's Hospital of Pittsburgh UPMC, Pittsburgh, PA, United States, 6Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, United States |
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An important role for cilia in congenital heart disease (CHD) pathogenesis has been seen in mouse model of CHD. There is a high prevalence of motile respiratory cilia dysfunction in human CHD patients. In this study, we investigate whether abnormal respiratory cilia motion in preadolescent CHD patients may be correlated with alterations in macroscopic CSF flow dynamics and poor executive cognitive function using phase contrast imaging. We show disturbance of CSF flow dynamics is significantly correlated with neurocognitive impairment in CHD subjects. |
| 850 | 15:09
|
Reduced Nasal Nitric Oxide Predicts Mis-matched Alterations in Regional Cerebral Perfusion and Functional Brain Connectivity in Older Children with Congenital Heart Disease |
1Radiology, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States, 2Children's Hospital of Pittsburgh, Pittsburgh, PA, United States |
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We investigate the relationship between congenital heart disease (CHD), regional CBF, functional connectivity, and nasal nitric oxide (nNO) levels in older children. Low nNO is associated with poor cardiac function in CHD although the precise mechanism is unknown. Results show that, in CHD patients, reduced nNO is associated with reduced regional CBF in the salience and default mode networks as well as reduced segregation globally (modularity) and regionally (frontally, parietally, and subcortically); these relationships are not present in normal controls. These results suggest intrinsic brain deficits (more so than impaired substrate delivery) may underlie neurocognitive deficits in CHD patients. |
| 851 | 15:21
|
Thalamic Lac/NAA threshold of 0.39 on proton MRS predicts outcome following therapeutic hypothermia in neonatal hypoxic ischemic encephalopathy |
1University College Hospital, London, United Kingdom, 2University College London, London, United Kingdom |
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Perinatal hypoxic ischemic brain injury remains a significant cause of neonatal morbidity and mortality. Accurate prediction of neurodevelopmental outcome following HIE is important for parental counselling and directing care towards optimised treatments. Proton MRS derived thalamic Lactate/N-acetylaspartate (Lac/NAA) peak area ratio at 1.5T was a robust MR outcome biomarker in the pre-cooling era; a cut off Lac/NAA of 0.29 accurately predicted outcome. The aim of this work is to identify the cut off threshold of thalamic Lac/NAA at 3T in the cooling era for outcome prediction. |
| 852 | 15:33
|
GABA levels in children with Autism and typically developing children differentially relate to social gesture performance |
1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Radiology, University of Calgary, Calgary, AB, Canada, 4Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, United States |
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Children with Autism (ASD) often suffer from motor abnormalities and the main inhibitory neurotransmitter GABA has been linked to ASD. We measure GABA in the primary sensorimotor cortex using MRS and measure praxis (social gesturing) in children with ASD and healthy children (TDC). We show that GABA is differentially related to social gestures in children with and without ASD. This suggests a complex relation between inhibition and gesture function. Reduced GABA levels may impair the performance of gestures with a communicative purpose, contributing to autistic phenotypes. Understanding the GABA system in ASD is important for developing patient-specific treatment in ASD. |
| Exhibition Hall 2418-2432 | Wednesday 16:15 - 18:15 | (no CME credit) |
| Exhibition Hall | Wednesday 16:15 - 17:15 | (no CME credit) |
| Exhibition Hall | Wednesday 16:15 - 17:15 | (no CME credit) |
| W07 | Wednesday 16:15 - 17:15 | (no CME credit) |
Organizers: Udunna Anazodo, Esther Warnert
| N03 | Wednesday 16:15 - 18:15 | Moderators: Daniel Gallichan & Penny Gowland | (no CME credit) |
16:15
|
Prologue: Why RESONATE in ISMRM? | |
1Lawson Health Research Institute, London, ON, Canada |
16:20
|
Monologue (Localizer #1): Towards Inclusiveness in ISMRM: Science in a Time of Growing Individualism | |
1The University of Western Ontario, Canada |
16:30
|
Monologue (Localizer #2): The Journey to Awareness of Social Bias in Science | |
1University of Southern California, United States |
16:40
|
Monologue (Localizer #3): The DTI of Social Implicit Bias in Science I | |
1Oslo Metropolitan University |
16:50
|
Monologue (Localizer #4): Towards RESONATE: Preventing & Reducing Biases Within ISMRM | |
1Radiology, Clinical Sciences, Lund University |
17:00
|
Dialogue (Scan): An Open-Guided Discussion on Localizers |
18:10
|
Epilogue (Recon): Summary, RESONATE In-phase | |
1Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands |
Organizers: Ulrike Dydak, Uzay Emir, Qiyong Gong
| N04 | Wednesday 16:15 - 18:15 | Moderators: Uzay Emir | (no CME credit) |
16:15
|
Functional Magnetic Resonance Spectroscopy for Cognitive Neuroscience & Psychiatry Research | |
1Psychiatry and Radiology, Yale University School of Medicine, New Haven, CT, United States |
16:45
|
Connectomic Insights into Anxiety & Depression | |
| TBD |
17:15
|
Linking Connectomics to Biochemical Trajectories of Aging: How the Human Brain Ages Differentially in Key Regions of the Default Mode | |
17:45
|
Connectome Dysfunctions & Treatment Modulations in Major Depressive Disorder | |
1Beijing Normal University, China |
Organizers: Marcus Alley, Bernd Jung
| S01 | Wednesday 16:15 - 18:15 | Moderators: Geon-Ho Jahng & Nicole Seiberlich |
16:15
|
Diffusion & Perfusion Weighted Imaging | |
1Department of Anatomy and Medical Imaging, School of Medical Sciences, The University of Auckland, New Zealand |
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This lecture is devoted to the basic technological aspects of diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) approaches used in MRI, using neuroimaging applications as examples, and with the concepts explained with minimal use of equations. PWI approaches covered are: dynamic susceptibility contrast (DSC) perfusion, dynamic contrast enhanced (DCE) perfusion, Arterial Spin Labeling (ASL), and the Intravoxel Incoherent Motion (IVIM) method. |
16:55
|
Parallel Imaging | |
1Fraunhofer IIS/MRB, Germany |
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In this presentation the basics of parallel Imaging are layed out. The talk will give a brief overview of the history of parallel MRI and the basic concept of multi-coil acquisition and reconstructions. Limitations and clinically most relevant applications will be duscussed. |
17:35
|
MR Angiography | |
1Depts. of Medical Physics & Radiology, University of Wisconsin - Madison, United States |
18:15
|
Adjournment & Meet the Teachers |
| Power Pitch Theater A - Exhibition Hall | Wednesday 16:15 - 17:15 | Moderators: Audrey Fan & Hirohiko Kimura | (no CME credit) |
| 853 | 16:15
|
Simultaneous measurements of global cerebral blood flow with 2D pseudo-continuous multi-TI arterial spin labeling and 15O-H2O PET in a hybrid PET/MR system |
1Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark |
| 854 | 16:15
|
Advanced lesion symptom mapping analyses and implementation as BCBtoolkit |
1BCBlab, Paris, France, 2Frontlab, Institut du Cerveau et de la Moelle épinière, Paris, France, 3Centre de Neuroimagerie de Recherche CENIR, Paris, France |
| 855 | 16:15
|
Validation of Cerebrovascular Reactivity by Arterial Spin Labeling MRI in Moyamoya Disease with Simultaneously Measured 15O-PET and Phase-contrast MRI |
1Radiology, Stanford University, Stanford, CA, United States, 2Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan, 3Applied Science Lab, GE Healthcare, Menlo Park, CA, United States, 4Neurosurgery, Stanford University, Stanford, CA, United States |
| 856
|
16:15
|
Adaptations in cerebral physiology due to chronic anaemia measured with Turbo-QUASAR ASL |
1Radiology & Nuclear Medicine, Academic Medical Center, Amsterdam, Netherlands, 2Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, 3Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, 4Cardiology and Radiology, Children's Hospital of Los Angeles, Los Angeles, CA, United States, 5Kate Gleason College of Engineering, Rochester Institute of Technology, Rochester, NY, United States, 6Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 7Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands, 8Haematology, Internal Medicine, Academic Medical Center, Amsterdam, Netherlands |
| 857
|
16:15
|
Noninvasive MRI measurements of oxygen extraction fraction reduction in response to blood transfusion in adults with sickle cell anemia |
1Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 2Pediatrics - Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, United States |
| 858 | 16:15
|
Relationship between the Degree of Unilateral Intracranial Artery Stenosis and Cerebral Perfusion: a High-resolution Intracranial Vessel Wall Imaging Study |
1First Clinical College,Tianjin Medical University, Tianjin, China, 2Department of Radiology,Tianjin First Central Hospital, Tianjin, China, 3Siemens Healthcare,MR Collaborations NE Asia, Beijing, China |
| 859 | 16:15
|
Identifying ischemic zone patterns and origins using multi-delay arterial spin labeling in vasospasm |
1University of Washington Medical Center, Seattle, WA, United States |
| 860
|
16:15
|
Non-contrast fingerprinting perfusion imaging reveals hemodynamic deficits in cerebrovascular diseases |
1The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 6Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 7Cognitive Science, Johns Hopkins University, Baltimore, MD, United States |
| 861 | 16:15
|
High-Resolution, Non-contrast Pseudo-Continuous Arterial Spin-Labeling (PCASL) MR-Angiography compared to standard clinical MRI in the detection of intracranial vessel pathologies with emphasis on intracranial arteriovenous shunts. |
1Radiology, Basel University Hospital, Basel, Switzerland, 2University of Wisconsin Madison, Madison, WI, United States, 3William Beaumont Hospital, Royal Oak, MI, United States |
| 862 | 16:15
|
Characteristics of Plaques and Lenticulostriate Arteries in Stroke Patients by Whole-Brain Vessel Wall Magnetic Resonance Imaging |
1Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China, 2Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, United States, 3MR Collaboration NEA, Siemens Healthcare, Beijing, China |
| 863 | 16:15
|
Comparison of velocity-selective and pulsed ASL perfusion MRI in patients with suspected cerebral cortical ischemia |
1Radiology, Massachusetts General Hospital, Boston, MA, United States, 2MGH/HST Martinos Center for Biomedical Imaging, Charlestown, MA, United States |
| 864 | 16:15
|
Intravoxel Incoherent Motion (IVIM) Perfusion Imaging in Hyperacute Stroke: Initial Results |
1University Hospital Basel, Basel, Switzerland, 2Neuroradiology, Stanford University, Stanford, CA, United States, 3Neurology, Stanford University, Stanford, CA, United States |
| 865 | 16:15
|
Superselective 4D MR Angiography with Pseudo-Continuous Arterial Spin Labelling Combined with CENTRA-Keyhole (SS-4D-PACK) Used to Visualize Brain Arteriovenous Malformations |
1Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2Philips Japan, Tokyo, Japan, 3Philips Research, Hamburg, Germany, 4Division of Radiology, Department of Medical Technology, Kyushu University Hospital, Fukuoka, Japan |
| 866 | 16:15
|
Impaired cerebrovascular reactivity assessed by BOLD hypercapnic fMRI is associated with increased risk of stroke in patients with symptomatic intracranial atherosclerotic stenosis |
1Department of Neurology, University Hospital Grenoble Alpes, Grenoble, France, 2Neuroradiology, University Hospital of Grenoble Alpes, Grenoble, France, 3Univ. Grenoble Alpes, Inserm, Grenoble Institute of Neurosciences, Grenoble, France, 4Univ. Grenoble Alpes, Inserm, CNRS, University Hospital Grenoble Alpes, IRMaGe, Grenoble, France |
| 867 | 16:15
|
Resting-State BOLD MRI for Evaluating Cerebrovascular Reserve in Stroke Patients |
1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States |
| Power Pitch Theater B - Exhibition Hall | Wednesday 16:15 - 17:15 | Moderators: Thomas Liu & Molly Bright | (no CME credit) |
| 868 | 16:15
|
Blood pressure correlated fluctuations of BOLD origin in fMRI signals: A multi-echo 7T study. |
1School of Physics and Astronomy, Cardiff University Brain Research imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom, 2School of Psychology, Caridiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom |
| 869 | 16:15
|
Determination of white matter cerebrovascular reactivity (CVR) and CVR compliance time responses to surgical revascularization using time regression analysis of hypercapnic BOLD fMRI data |
1Dept. of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 2Quantitative and Physical Biology Program, Vanderbilt University Medical Center, Nashville, TN, United States, 3Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States, 4Dept. of Neurology, Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 5Dept. of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, United States |
| 870
|
16:15
|
Differentiating neural and non-neural fMRI signals using CBV-BOLD fMRI |
1SFIM, NIMH, Bethesda, MD, United States, 2FMRIF, NIMH, Bethesda, MD, United States, 3MBIC, Maastricht, Netherlands, 4MPI-CBS, Leipzig, Germany |
| 871 | 16:15
|
Local neuronal synchronization and global functional disconnection are signatures of propofol-induced unconsciousness |
1University of Michigan, Ann Arbor, MI, United States, 2Medical College of Wisconsin, Milwaukee, WI, United States |
| 872 | 16:15
|
Absolute quantification of resting oxygen metabolism and cerebral physiology following acute exposure to repeated sub-concussive collisions: A calibrated MRI approach |
1Centre of Neuroscience studies at Queen's University, Kingston, ON, Canada, 2Cardiff University Brain Research Imaging Centre, Cardiff, United Kingdom, 3Department of Surgery at Queen's University, Kingston, ON, Canada |
| 873 | 16:15
|
Evaluation of task-induced δCMRO2 with a simultaneous acquisition of CBV, CBF and BOLD signals during normoxia and hypoxia conditions |
1Center for MRI Research, Peking University, Beijing, China, 2Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China, 3Beijing City Key Lab for Medical Physics and Engineering, Peking University, Beijing, China, 4MR Research China, GE Healthcare, Beijing, China |
| 874 | 16:15
|
Using measured Haemodynamic Response Functions in Population Receptive Field mapping at 7 T |
1SPMIC, University of Nottingham, Nottingham, United Kingdom, 2University of Nottingham, Nottingham, United Kingdom |
| 875 | 16:15
|
Visual temporal frequency preference shows a distinct cortical architecture using fMRI |
1National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States |
| 876
|
16:15
|
A Probabilistic Atlas of Digit Somatotopy in the Human Primary Somatosensory Cortex |
1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 2School of Psychology, University of Nottingham, Nottingham, United Kingdom, 3Department of Psychology, American University of Beirut, Beirut, Lebanon |
| 877 | 16:15
|
Modeling Motor Task Activation from Task-free fMRI with Machine Learning: Predictions and Accuracy in Individual Subjects |
1Medical College of Wisconsin, Milwaukee, WI, United States, 2First Affiliated Hospital of Xi'An Jiaotong University, Shaanxi Xi'an, China, 3Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), University of Oxford, Oxford, United Kingdom |
| 878 | 16:15
|
Performing Sparse Regularization and Dimension Reduction Simultaneously in CCA-Based Data Fusion |
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of Colorado, Boulder, CO, United States |
| 879 | 16:15
|
Evidence of Dense Functional Connectivity in the Human Brain |
1Department of Computer Science and Engineering, Indian Institute of Technology Delhi, New Delhi, India, 2Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, United States |
| 880 | 16:15
|
Matrix Tri-Factorization for BOLD-fMRI |
1UCL, London, United Kingdom |
| 881 | 16:15
|
Effect size and result overlap between individual and group results in fMRI studies |
1Radiology, UZ Brussel (VUB), Brussels, Belgium, 2Psychiatry, UZ Brussel, Brussel, Belgium, 3Psychiatry and Medical Psychology, UGent, Ghent, Belgium, 4Radiology, UZ Brussel, Brussels, Belgium |
| 882
|
16:15
|
Cross-vendor harmonization of T2-Relaxation-Under-Spin-Tagging (TRUST) MRI for the assessment of cerebral venous oxygenation |
1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States |
| N01 | Wednesday 16:15 - 18:15 | Moderators: Dmitry Novikov & Ileana Jelescu |
| 883 | 16:15
|
Including diffusion frequency dependence in the extra-axonal space to improve axonal diameter mapping using trapezoidal OGSE sequences |
1UNIRS, CEA/ISVFJ/Neurospin, Gif-sur-Yvette, France, 2UNATI, CEA/ISVFJ/Neurospin, Gif-sur-Yvette, France, 3INM-1 Forschungszentrum Jülich, Jülich, Germany |
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We performed Monte-Carlo simulations of the diffusion process in 3D biomimetic geometries accounting for the angular dispersion and tortuosity present in white matter. Diffusion MRI data synthesis using clinically plausible trapezoidal OGSE sequences was then performed and an extra-axonal linear-in-frequency dependence of the perpendicular diffusivity transverse to axons was observed over a wide range of axon diameter values. Simulated data was fed into an ActiveAx trapezoidal OGSE model accounting for this frequency-dependence. The estimation of axonal diameter is improved by this correction. |
| 884 | 16:27
|
LEMONADE(t): Exact relation of time-dependent diffusion signal moments to neuronal microstructure |
1Center for Biomedical Imaging, New York University, New York, NY, United States |
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The purpose of this work is to solve the two complementary problems: (i) Estimate the time-dependent (non-Gaussian) signatures of intra- and extra-neurite tissue compartments separately, irrespective of neurite orientational dispersion; and (ii) cure the notorious degeneracy in parameter estimation of multi-compartment models. We derive exact relations between time-dependent 2nd- and 4th-order signal moments, and all relevant time-dependent diffusion parameters in the intra- and extra-neurite space. Remarkably, the temporal dimension lifts the degeneracy in parameter estimation: The relations are formally invertible, multiple "branches" of solutions do not appear, and time-dependent DKI is enough to estimate all parameters. Precision, though, remains a challenge. |
| 885 | 16:39
|
Diffusion Time Dependence of NODDI in in vivo Human White Matter |
1Radiology, Juntendo University School of Medicine, Tokyo, Japan, 2Radiology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, 3Siemens Japan K.K., Tokyo, Japan, 4Siemens Healthcare GmbH, Erlangen, Germany |
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We investigated the diffusion time dependency of diffusion metrics, especially ICVF and INVF, compared with ADC using an oscillating gradient spin-echo sequence in in vivo human white matter at 3T. Our results show that the change ratio of both ICVF and INVF indicate similar tendency in the same white matter locations, with or without diffusivity calculation. Moreover, with higher oscillating frequency, ICVF decreased but ISOVF stayed almost unchanged, indicating that the rate of ICVF and the extra-cellular component may change with oscillating frequency beside the unchanged isotropic water component. |
| 886 | 16:51
|
Implications of nongaussian diffusion on the interpretation of multidimensional diffusion measurements |
1CFIN/MINDLab, Aarhus University, Aarhus C, Denmark, 2Dep. Physics and Astronomy, Aarhus University, Aarhus C, Denmark, 3Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal, 4Center for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom |
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Multidimensional diffusion weighting, such as magic angle spinning of the q-vector (q-MAS), relies on the assumption of multiple Gaussian compartments (MGC). Then the kurtosis measured with q-MAS can be fully ascribed to ensemble variance of isotropic diffusivity. However, in compartments with nongaussian diffusion, anisotropic time dependence of the diffusion tensor imparts orientation dependence on the q-MAS measured mean diffusivity, which in the presence of orientation dispersion leads to additional contributions to kurtosis. Yet another contribution arises from intracompartmental kurtosis. Using simulations and experiments we demonstrate that q-MAS derived diffusion kurtosis conflates variance in isotropic diffusivity with dispersion and intracompartmental kurtosis. |
| 887 | 17:03
|
Spectral anisotropy in multidimensional diffusion encoding |
1Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 2Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden, 3Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, 4Department of Chemistry, Lund University, Lund, Sweden, 5Random Walk Imaging AB, Lund, Sweden |
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To account for time-dependent diffusion in multidimensional diffusion encoding (MDE), the relevant temporal characteristics of encoding waveforms need to be identified and controlled. Based on the frequency domain analysis, we suggest a framework for analyzing the spectral content in MDE, which is useful to experimentally disentangle the effects of time-dependent diffusion. We introduce a novel concept of spectral anisotropy and demonstrate how differentiated temporal characteristics along orthogonal encoding axes may be used to isolate time-dependent diffusion in anisotropic domains, which is not possible with existing approaches without a priori model assumption. |
| 888 | 17:15
|
On the vanishing of the t-term in the short-time expansion of the diffusion coefficient for oscillating gradients in diffusion NMR |
1Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 2Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany |
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The short-time expansion of the diffusion coefficient in powers of t1/2 is universally connected to structural parameters of the boundaries restricting the diffusive motion. The t1/2-term is proportional to the surface-to-volume ratio. The t-term is related to permeability and curvature. The short-time expansion can be measured by application of oscillating gradients of long total duration. For oscillating gradients, the inverse of the oscillation frequency becomes the relevant time scale. The purpose of this work is to show that the oscillating gradient approach is blind to the t-term. Thus, the t-term does not bias the determination of the t1/2-term in experiments. |
| 889 | 17:27
|
Towards new modalities for probing the microstructure at very high b-values |
1Laboratory of Condensed Matter Physics, CNRS, Palaiseau, France |
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Modern clinical and animal scanners offer versatile options for diffusion MRI, including very high b-values, at which the conventional perturbative description and related model are not applicable. We demonstrate this failure for any nontrivial domain with a boundary, regardless its shape and permeability. Since the magnetization is localized near boundaries, the signal becomes more sensitive to the microstructure. Even the signal from the extracellular diffusion is shown to be non-Gaussian at high b-values. These non-Gaussian features offer new imaging modalities at ordinary gradients accessible on most MRI scanners but, if unnoticed, they may result in misleading biomedical interpretations. |
| 890 | 17:39
|
Imaging Microscopic Background Gradient Variations in the Mouse Brain |
1Dept. of Radiology, New York University School of Medicine, New York, NY, United States, 2Dept. of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States |
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Microstructures in biological tissues can produce susceptibility related microscopic background gradient (μBG). Mapping the spatial distributions of μBG can help us infer tissue microstructure. In this study, we reported an improved diffusion MRI based method to detect μBG and evaluated the method using a phantom as well as normal and dysmyelinated mouse brains. We found that 3D spatial variations of μBG were greater in white matter tracts than in gray matter structures. The contrast based on μBG spatial variations was able to distinguish white matter tracts in normal and dysmyelinated mouse brains. The method may be used to study myelin injury. |
| 891
|
17:51
|
In-vivo diffusion-fMRI using Incomplete Initial Nutation Diffusion Imaging (INDI) |
1Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, 2Department of Computer Science, University College London, London, United Kingdom |
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Diffusion functional-MRI (dfMRI) aims to capture microstructural changes occurring with neural activity. One of the confounding factors for dfMRI is that zero and nonzero b-values need to be acquired to deliver accurate changes in diffusivity, and those images are typically separated by at least one repetition time. Recently, Incomplete initial Nutation Diffusion Imaging (IDNI) was proposed for mapping the two images with a separation of <50ms. Here, we performed the first INDI-fMRI experiments using forepaw-stimulated rats. Functional signals are captured well both in ROI and voxel-wise analyses, enabling a more direct comparison of each signal’s time course. |
| 892 | 18:03
|
Abundance of cell bodies can explain the stick model’s failure in grey matter at high b-value |
1Computer Science Department and Centre for Medical Imaging Computing, University College London, London, United Kingdom, 2Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal |
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This work investigates the validity of the stick model used in diffusion-weighted MRI for modelling cellular projections in brain tissue. We hypothesize that the model will fail to describe the signals from grey matter due to an abundance of cell bodies. Using high b-value (≥3 ms/µm2) data from rat and human brain, we show that the assumption fails for grey matter. Using diffusion simulation in realistic digital models of neurons/glia, we demonstrate the breakdown of the assumption can be explained by the presence of cell bodies. Our findings suggest that high b-value data may be used to probe cell bodies. |
| N02 | Wednesday 16:15 - 18:15 | Moderators: Dinggang Shen & Greg Zaharchuk |
| 893
|
16:15
|
Classification of Dense Tumor, Tumor Necrosis and Tumor Infiltration in Glioma: Machine Learning and Diffusion MRI |
1Radiology, Washington University School of Medicine, St. Louis, MO, United States, 2Electrical & System Engineering, Washington University in St. Louis, St. Louis, MO, United States, 3Neurological Surgery, Washington University School of Medicine, St. Louis, MO, United States, 4Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States, 5Immunology and Pathology, Washington University School of Medicine, St. Louis, MO, United States |
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Here we introduce a diffusion MR-based imaging technique - Diffusion MRI Histology (D-Histo), to detect and differentiate various co-existing tumor pathologies including high-cellularity tumor (tumor), tumor necrosis (necrosis) and tumor infiltration (infiltration) within high grade glioma. We incorporated a support vector machine algorithm to generate an automation framework to predict locations of tumor lesion, necrosis and infiltration. The mean predictive accuracy of the D-Histo SVM classifier for tumor lesion, necrosis and infiltration were 91.9%, 93.7% and 87.8%. DTI-based prediction under the same framework resulted in 44.4%, 56.0% and 43.0% accuracy for the three pathologies. |
| 894
|
16:27
|
Machine learning with amide proton transfer and magnetization transfer MRI for predicting IDH mutation status in diffuse gliomas |
1Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China, 3Department of Pathology, Zhujiang Hospital, Southern Medical University, Guangzhou, China, 4Department of Pathology, Johns Hopkins University, Baltimore, MD, United States, 5F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States |
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The current diagnostic criterion for IDH mutation status is based on lab tests via surgical tissue samples. APTw and MT imaging contrast mechanisms can detect low-concentration mobile proteins and semi-solid macromolecules, respectively. We implemented a support vector machine (SVM)-based method to predict IDH1/2 genotype in gliomas using APTw and MT MRI features. 105 WHO Grade II and III glioma patients with complete imaging and genetic data were enrolled. Within the supervised classification framework, our results suggest that the use of APTw and MT features enabled the SVM to reach the accurate diagnosis of the IDH genotype in gliomas. |
| 895
|
16:39
|
Biomarkers for CTE diagnosis in retired NFL player using Machine learning |
1Electrical and Computer Engineering, Boston University, Boston, MA, United States, 2Department of Neurology, Boston University, Boston, MA, United States, 3Center for Clinical Spectroscopy, Brigham and Women's hospital, Boston, MA, United States, 4Boston University, Boston, MA, United States |
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Multiple concussions have the potential to develop Chronic Traumatic Encephalopathy (CTE), a neurodegenerative disease that is currently diagnosed only in postmortem by tau protein deposition in the brain. Since repetitive head trauma alters brain morphology and metabolism, magnetic resonance imaging and spectroscopy could be suitable candidates for CTE diagnosis. Therefore, we propose machine learning-based approach to identify CTE-related biomarkers. The model achieves 80% prediction accuracy with AUC of 0.72 using creatine, macromolecules and brain volume as features for the machine learning model. |
| 896 | 16:51
|
Prediction of Tumor Progression Time Interval in Malignant Glioma Using Textural Information derived from FLAIR and T1c MR-images and Machine Learning |
1Institute for Diagnostic and Interventional Neuroradiology, University Hosiptal Bern, Bern, Switzerland, 2Institute of Radiooncology, University Hosiptal Bern, Bern, Switzerland, 3Institute of Pathology, University Bern, Bern, Switzerland, 4Center for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland, 5Neurosurgery, University Hosiptal Bern, Bern, Switzerland |
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Glioma-patients get regular neuroradiological MRI-follow-ups to evaluate the tumor-progression-status. In this study it was investigated whether it is possible to predict tumor progression within the next follow-up period, from progression on a longer time-scale. The T1c- and FLAIR-images of two times 20 patients were investigated; one group having stable-disease at two subsequent follow-ups (ST-ST), the second group showed stable-disease during the first but progressive-disease during the second follow-up (ST-PR). By applying machine-learning (random-forests) on textural MRI-information, short-term progression could be predicted with an accuracy of 77.5%. This novel type of information can have an impact on improved personalized-treatment of glioma-patients. |
| 897 | 17:03
|
Radiogenomics of 154 WHO grade 2 and 3 gliomas via machine learning and the impact of texture analysis |
1Osaka International Cancer Institute, Osaka, Japan, 2Kansai Molecular Diagnosis Network for CNS Tumors, Osaka, Japan, 3Saga University, Saga, Japan, 4National Cancer Center Hospital, Tokyo, Japan, 5National Cancer Center Research Institute, Tokyo, Japan, 6Osaka National Hospital, Osaka, Japan |
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In this research, the authors performed radiomics for 154 LrGG and attempted to build a MRI based predictive model to classify clinically relevant 3 LrGG subgroups using machine learning algorithm. The impact of texture analysis such as GLCM and GLRLM on building the model was also investigated. Accuracy for predicting 3 molecular subgroups were 0.587 without and 0.546 with texture analysis. Although radiomics was shown to be a powerful tool to identify genetic subgroups of LrGG, little improvement is expected from texture analysis. |
| 898 | 17:15
|
Identifying Individual Motor Function Using Machine Learning Predication Based on Resting-State fMRI for Presurgical Mapping in Patients with Brain Tumor |
1First Affiliated Hospital of Xi'An Jiaotong University, Shaanxi Xi'an, China, 2Medical College of Wisconsin, Milwaukee, WI, United States |
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A novel machine learning model was developed using resting-state and task fMRI on healthy subjects. This study applied this novel model to clinical patients. Preliminary data on 25 patients with space-occupying brain tumors suggested our approach could accurately predict hand functional area at the individual level in patients with brain tumors, even in cases where patients had displacement of brain tissue and reorganization of brain motor functional network. Our methods implicated the great potential for clinical application of presurgical mapping. |
| 899 | 17:27
|
Machine learning and rapid multi-parametric relaxometry can differentiate demyelinating disorders with high accuracy |
1NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 2Athinoula A. Martinos Center for Biomedical Imaging, MGH, Charlestown, MA, United States, 3Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, 4Department of Radiology, Division of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden, 5Department of Neurology, Karolinska University Hospital, Stockholm, Sweden, 6Center for Medical Imaging Science and Visualization, CMIV, Linköping, Sweden, 7SyntheticMR, Linköping, Sweden, 8Montreal Health Institute, Montreal, QC, Canada, 9Harvard Medical School, Boston, MA, United States, 10Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada |
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Hereditary diffuse leukoencephalopathy with spheroids (HDLS) and multiple sclerosis (MS) are both demyelinating and neurodegenerative disorders that can be hard to distinguish clinically and radiologically. Here, we present a machine learning method that relies on rapid multi-parametric relaxometry and volumetry to achieve a robust classification of HDLS vs. MS. Linear discriminant analysis was shown to be a favorable approach compared to non-linear options. A leave-one-out cross-validation show a detection rate of 100% and 0% false positives for both conditions, which suggests that computer-assistance maybe helpful in accurately diagnosing these disorders. |
| 900 | 17:39
|
Early Prediction of Language Deficits in Very Preterm Infants Using Functional Connectome Data and Machine Learning |
1Perinatal Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States, 3Pediatric Neuroimaging Research Consortium, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States |
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Children who are born prematurely are at an increased risk for impaired neurodevelopmental outcomes, including language deficits. Earlier identification, soon after birth, of infants who are experiencing difficulties with complex language function is urgently needed to take advantage of critical windows of brain development so that targeted delivery of Early Intervention therapies can be undertaken during this optimal period. We propose to develop a robust machine learning framework that can analyze functional brain connectome data obtained at term corrected age to make an individual-level prediction about language outcomes at two years corrected age in very preterm infants. |
| 901 | 17:51
|
Machine learning classification of Parkinson’s disease using brainstem MRI and demographic features |
1Neurology, Emory University School of Medicine, Atlanta, GA, United States, 2Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, United States, 3Center for Advanced Neuroimaging, University of California Riverside, Riverside, CA, United States, 4Biomedical Engineering, Emory University School of Medicine, Atlanta, GA, United States, 5Bioengineering, University of California Riverside, Riverside, CA, United States |
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Objective biomarkers for Parkinson’s disease (PD) are needed, and a PD MRI diagnostic could have high impact in clinical and research applications. 3T MRI sequences sensitive to neuromelanin loss and iron accumulation in substantia nigra pars compacta and locus coeruleus robustly detect PD effects. We hypothesized that a multivariate MRI classifier can differentiate PD from controls with high accuracy. A machine learning classifier was developed using data from PD and controls (n=67) with brainstem MRI and demographic features as model inputs. Using 5-fold cross-validation the model demonstrated 86% accuracy, which is in a clinically useful range and warrants further development. |
| 902 | 18:03
|
Improved Prediction of the Final Infarct from Acute Stroke Neuroimaging Using Deep Learning |
1Tsinghua University, Beijing, China, 2Stanford University, Stanford, CA, United States |
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Magnetic Resonance Imaging (MRI) is a widely-used technique for clinics. Its advantages in providing multiple complimentary contrasts make it the best image tool for detecting presenting lesions in the brain. A lot methods have been proposed for lesion detection and segmentations using machine learning techniques. It is more sophisticated than common computer vision tasks since the estimation of treatment outcomes are not merely determined by lesions captured by current MR images. We targeted to develop an algorithm, based on 3D Convolutional Neural Network, to predict the final lesion shown on day-90 scans by processing the day-0 acute stroke images. |
| S02 | Wednesday 16:15 - 18:15 | Moderators: Jens Rosenberg & Monique Bernard |
| 903
|
16:15
|
A Continuum of Components: Robust Parameter Mapping in Sodium MRI |
1Dept. of Biomedical Engineering, The University of Melbourne, Melbourne, Australia, 2Melbourne Brain Centre Imaging Unit, The University of Melbourne, Melbourne, Australia |
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Bi-exponential models of T2*-weighted sodium data are prone to producing noisy parameter maps and low contrast between brain tissue types. Further, inherently low SNR has, to this point, necessitated a constant fast fraction weight. Here, a continuum model of sodium T2*-decay is introduced and applied to in vivo human multi-echo 7T data, producing high quality, high contrast parameter maps, and informative voxelwise estimates of the relative weighting between fast and slow decay components. |
| 904
|
16:27
|
High Field Hyperpolarized C-13 Dynamic Diffusion Weighted Imaging Based on Slice Selective Double Spin Echo Sequence |
1Bioengineering, UCSF & UC Berkeley, San Francisco, CA, United States, 2Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States |
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We designed and optimized a dynamic double spin echo (DSE) acquisition scheme for hyperpolarized(HP) 13C metabolites dynamic diffusion weighted imaging(DWI). Compared to traditional DSE sequence, our sequence could provide higher SNR for longer dynamic imaging duration. Our studies on TRAMP mice indicate a dynamic change of HP lactate ADC over time, which might have potential to improve the assessment of aggressive cancers. |
| 905 | 16:39
|
PET by MRI: Glucose Imaging by 13C MRS by Noise Suppression through Tensor Decomposition Rank Reduction |
1Radiation Biology, NIH/NCI, Washington DC, DC, United States, 2NIH/NINDS, Bethesda, MD, United States, 3GE HealthCare, Dallas, TX, United States, 4Applied Science Laboratory, GE HealthCare, Menlo Park, CA, United States, 5GE HealthCare, Toronto, ON, Canada, 6Technical University of Denmark, Lyngby, Denmark |
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We show here a new method of imaging glucose metabolism in vivo by 13C MRS without DNP that relies on a simple but efficient postprocessing procedure using the higher dimensional analogue of SVD, tensor decomposition. Using this procedure, without sacrificing accuracy, we achieve an order of magnitude increase in SNR in both DNP and non-hyperpolarized single voxel experiments. In CSI imaging experiments, we see an approximately 30 fold increase in SNR, enough that the glucose to lactate conversions can be imaged with a time resolution of 12 seconds and an overall spatial resolution that compares favorably to 18F-FDG PET. |
| 906 | 16:51
|
Deuterium Metabolic Imaging (DMI) of Human Brain Glucose Metabolism |
1Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 2Department of Psychiatry, Yale University, New Haven, CT, United States, 3Department of Biomedical Engineering, Yale University, New Haven, CT, United States |
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Deuterium Metabolic Imaging (DMI) is a novel approach providing high 3D spatial resolution metabolic data from both animal models and human subjects. DMI relies on 2H MRSI in combination with administration of 2H-labeled substrates. We show how DMI combined with administration of [6,6’-2H2]-glucose can image glucose uptake and metabolism at high spatial resolution in human brain at 4T. We provide longitudinal and transverse relaxation times of 2H-labeled brain metabolites at 4T and 11.7T to support further development and optimization of DMI applications. |
| 907 | 17:03
|
A Pilot Study for In Vivo Measurement and Quantification of Brain Glucose Metabolic Rates using Oral Uptake of Deuterated Glucose |
1Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States |
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Recently, we developed a novel Deuterium MRS (DMRS) approach for simultaneously measuring cerebral glucose consumption rate and TCA cycle flux in rat brains at 16.4 T. Instead of using a clamp protocol in 13C MRS studies, our DMRS approach utilizes a brief i.v. infusion of glucose isotope. In this work, we aimed to establish a completely noninvasive delivery of the tracer into brain. By using oral uptake, DMRS detection sensitivity was evaluated and metabolic rates were quantified. Our results demonstrated the feasibility of using oral uptake for DMRS applications, which makes it highly suitable and promising for translation to patients. |
| 908
|
17:15
|
Compressed Sensing Improves Detection of Fluorine-19 Nanoparticles in a Mouse Model of Neuroinflammation |
1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2Experimental and Clinical Research Center (ECRC), Charité Campus Buch, Berlin, Germany |
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Low sensitivity remains a major challenge on the way to utilizing the full potential of 19F-MRI, despite its unique detection specificity for imaging inflammation. Compressed sensing allows the reconstruction of high quality images from severely undersampled data by relying on prior statistical knowledge. We show that investing the gained acquisition speed into increased averaging improves the detection of 19F-nanoparticles in an EAE mouse model. Thus compressed sensing helps to improve the sensitivity of 19F-MRI. This paves the way to enhanced spatial and temporal resolution for future in vivo studies. |
| 909 | 17:27
|
Systemic Inflammation Adversely Affects Mitochondrial Function as Assessed by 31P MRS of Thigh Muscle with Exercise |
1Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States, 2Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 3Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States |
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Systemic inflammation has been shown to play a role in both the aging process and disease progression. However, the effect of inflammation on mitochondrial function has not been fully elucidated. We hypothesized that increased systemic inflammation, assessed through measurement of conventional markers of inflammation, would be accompanied by a decrease in mitochondrial function, as assessed by 31P MRS of leg muscle. Our results suggest that increased systemic inflammation may adversely affect mitochondrial function. |
| 910 | 17:39
|
Mapping of Creatine Kinase Reaction Rate in Rat Hindlimb by 31P Magnetic Resonance Fingerprinting |
1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Radiology, Case Western Reserve University, Cleveland, OH, United States |
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Magnetic Resonance Fingerprinting (MRF) allows the quantification of multiple tissue parameters with high efficiency. Previously, we developed an MRF based 31P spectroscopic method for fast and robust measurement of ATP synthesis via creatine kinase (CK). In the current study, we explored the potential of combining the CK-MRF method with fast imaging for metabolic mapping of the CK reaction rate in small laboratory animals. CK-MRF imaging was performed in the hindlimb of four rats. CK rates of different muscle compartments were compared. |
| 911
|
17:51
|
Accelerating Low-Rank Tensor Model Based Dynamic 31P-MRSI of Ischemia-Reperfusion in Rat at 9.4T |
1Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 4Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States, 5Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, 6Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States |
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Dynamic 31P-MRS/MRSI is often used to assess mitochondrial oxidative capacity in skeletal muscle by monitoring the depletion and recovery of the phosphocreatine concentration during ischemia-reperfusion experiments. In animal models, standard methods are unable to provide the spatiotemporal resolution needed to discern spatial heterogeneity of the recovery process ($$$<$$$10 s/frame, $$$\approx$$$1 mm3 per voxel). To address this problem, we have improved a recently proposed low-rank tensor based method for accelerated high-resolution dynamic 31P-MRSI to provide in vivo results with 1.5x1.5x2 mm3 nominal spatial resolution, 36 ppm spectral bandwidth, 0.14 ppm spectral resolution, and 5.1 s temporal resolution. |
| 912 | 18:03
|
Down-regulation of phospholipid biosynthesis is a unique metabolic feature of mutant IDH1 gliomas mediated by autophagy of the endoplasmic reticulum |
1Radiology, University of California San Francisco, San Francisco, CA, United States, 2Neurosurgery, University of California San Francisco, San Francisco, CA, United States |
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Virtually every cancer studied so far shows elevated choline and ethanolamine phospholipid metabolism, which has emerged as a metabolic hallmark of cancer. Here, we show that, unusually, low-grade gliomas carrying a mutation in isocitrate dehydrogenase 1 (IDHmut) down-regulate phosphatidylcholine and phosphatidylethanolamine biosynthesis and steady-state levels. Mechanistically, this down-regulation is mediated via autophagic degradation of the endoplasmic reticulum, the site of phospholipid biosynthesis. Importantly, the autophagy inhibitor chloroquine restores phospholipid levels and abrogates IDHmut tumor growth, identifying a potential therapeutic opportunity. Thus, our study demonstrates that IDHmut gliomas uniquely down-regulate phospholipid biosynthesis and that this phenomenon can be exploited for therapy. |
| S03 | Wednesday 16:15 - 18:15 | Moderators: Dariusch Hadizadeh Kharrazi & Ruth Lim |
| 913
|
16:15
|
Highly Accelerated Steady State Ferumoxytol Abdominal MRA using Compressed Sensing |
1Radiology, University of California, San Francisco, San Francisco, CA, United States, 2Siemens Healthcare, San Francisco, CA, United States, 3Siemens Healthcare, Erlangen, Germany |
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Clinical CE-MRA of the abdomen is limited in spatial resolution/coverage, or is excessively time consuming. We implemented a compressed sensing (CS) steady state MRA technique with an acceleration factor of 25, achievable in a 15 second breath hold, with 0.8mm isotropic resolution and a large 48cm coverage. In an investigation on 13 patients, we found CS-MRA had higher image quality scores and vessel sharpness compared with free breathing high-resolution MRA and clinical breath hold low-resolution MRA, with a reduced scan time. Our proposed CS-MRA technique is promising for the evaluation of abdominal vessels. |
| 914 | 16:27
|
Ferumoxytol-Enhanced 4D MUSIC: Early Multi-Center Experience on Value-Added Magnetic Resonance Imaging in Pediatric Congenital Heart Disease |
1Department of Radiological Sciences and Medicine, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States, 2Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States, 3Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 4Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 5Department of Radiological Sciences and Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States |
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The value of MRI in congenital heart disease (CHD) is well-recognized. However, high time overhead and the requirement for expert oversight of image acquisition impede its more widespread use. Ferumoxytol-enhanced 4-dimensional multiphase imaging with contrast (4D-MUSIC) is a cardiac phase-resolved MR technique that generates highly detailed images under controlled ventilation. Our early multi-center experience demonstrates that 4D-MUSIC provides value-added imaging in CHD by shortening the examination time, simplifying the imaging protocol, and providing reliable, gadolinium-free, high spatial resolution, cardiac phase-resolved images. When combined with locally available velocity mapping, 4D-MUSIC enables comprehensive imaging of complex CHD in less than 40 minutes. |
| 915 | 16:39
|
Lipid-insensitive 4D motion-resolved free breathing coronary MRA in heart transplant recipients at 3T |
1Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 2School of Biomedical Engineering and Imaging Sciences, King’s College London, Lausanne, Switzerland, 3Cardiology Service, Lausanne University Hospital (CHUV), Lausanne, Switzerland, 4Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 5Center for Biomedical Imaging, Lausanne University Hospital (CHUV), Lausanne, Switzerland |
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The purpose of this study was to investigate coronary magnetic resonance angiography (MRA) at 3T as a possible alternative to invasive X-ray coronary angiography for the visualization of proximal and mid segments of the coronary arterial system in heart transplant recipients. Therefore, a lipid-insensitive binomial off-resonance excitation (LIBRE) pulse was optimized and combined with a 3D radial whole-heart sequence. Respiratory-self-navigated MRA was performed at 3T in heart transplant recipients during and after Gd infusion, and was compared with respiratory-motion compensation using compressed sensing (CS) to define the preferred acquisition and reconstruction protocol in this patient group. |
| 916 | 16:51
|
Iterative Reconstruction for Dynamic Contrast-Enhanced MR Angiography of the Thoracic Aorta: Quantitative Assessment of SI Parameters and Impact on Quantitative Vessel Characteristics |
1Department of Medical Imaging, University of Toronto, Toronto, ON, Canada, 2Siemens Healthcare, Erlangen, Germany |
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Iterative reconstruction methods can improve vessel depiction in thoracic contrast-enhanced MR angiography, particularly in small vasculature. This improvement can be ascribed to the reduced temporal footprint for iterative reconstruction compared to view sharing for standard reconstruction. An investigation of the effects of this new reconstruction on quantitative vessel characteristics found no bias in vessel diameter measurements compared to the reference. |
| 917 | 17:03
|
Time-resolved dynamic contrast enhanced MR imaging of the pulmonary vasculatures and parenchyma using Fat-sat DISCO with Gadobutrol |
1Radiology, Seirei Hamamatsu General Hospital, Hamamatsu, Japan, 2Global MR Applications and Workflow, GE Healthcare, Hino, Japan, 3Global MR Applications and Workflow, GE Healthcare, Madison, Japan |
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Fat-sat DISCO is modified version of DISCO, based on LAVA with view-sharing, which can be used for dynamic contrast MR imaging with high temporal resolutions. Gadobutrol has higher concentration of Gadolinium and its single bolus injection might induce T2 shorting effects. Simultaneous bolus injection of Gadobutrol and saline may suppress T2 shorting effects and will facilitate enhancement on T1-weighted imaging. Using fat-sat DISCO with simultaneous bolus injection of Gadobutrol and saline, dynamic contrast MR imaging of the lung can steadily provide selective visualization of pulmonary vasculatures and parenchymal enhancement. |
| 918
|
17:15
|
Whole-Heart Cartesian Coronary MRA with Sub-Millimeter Isotropic Resolution in Four-Minute Acquisition |
1Biomedical Engineering Department, King's College London, London, United Kingdom, 2Siemens Healthcare Limited, Frimley, United Kingdom |
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Whole-heart coronary magnetic resonance angiography (CMRA) with isotropic resolution allows reformatting in any desired imaging plane without loss of resolution. However, achieving sub-millimeter isotropic resolution with a conventional 1D diaphragmatic navigator gated CMRA is very challenging due to long and unpredictable scan times. In this study, we sought to achieve sub-millimeter CMRA by combining 2D image-based navigator motion correction with highly accelerated compressed sensing reconstruction in concert with variable density Cartesian spiral-like k-space sampling to significantly accelerate the scan. The proposed technique enables CMRA acquisitions with 0.9mm isotropic spatial resolution in about 4 minutes. Ultimately, this technique might be useful for rapid screening of the coronaries in patients with suspected coronary artery disease. |
| 919 | 17:27
|
Automated Coil Ranking using a Neural Network for Image Quality Assessment: An Explorative Study in Coronary MRI |
1Department of Radiology, University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland, 2Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 3Institute of Bioengineering/Center for Neuroprosthetics, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, 5LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland |
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A novel method that uses a neural network to rank individual coil elements of phased arrays based on their image quality is proposed. With a ranking of the coil elements, the specific subset of coils that leads to the best image reconstruction can be selected. Alternatively, the contribution of coils with high levels of artifacts and noise to the final image can be reduced. We show that both selection and weighting of coil elements can reduce the level of image artifacts while maintaining a high signal intensity in the region of the examined organ. |
| 920 | 17:39
|
Improved Design and Reconstruction of 3D Image Based Navigators for Coronary MR Angiography |
1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Palo Alto, CA, United States |
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We present a novel method to acquire whole-heart 3D image-based navigators (iNAVs) for tracking and correction of localized motion in free-breathing coronary angiography. More specifically, a variable-density, phyllotaxis-based trajectory is utilized for homogeneous sampling of the desired k-space extent. To reconstruct the 3D iNAVs, a locally low rank regularized iterative scheme is implemented. Across all volunteer studies, compared to 3D iNAVs generated with prior design and reconstruction strategies, the proposed 3D iNAVs provide superior delineation of the structures of interest. Application of the proposed 3D iNAVs for motion correction in volunteer studies yields improved depiction of the coronary arteries. |
| 921 | 17:51
|
Accuracy of ECG-triggered Non-contrast Enhanced MRA (TRANCE) versus CT Angiography for diagnosis of peripheral artery disease: Comparison with DSA |
1MRI, The 1st affiliated hospital of Henan University of TCM, Zhengzhou, China, 2PHILIPS Healthcare, Beijing, China |
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There is an increasing clinical need for implementing a Non-contrast enhanced MRI technique for patients with PAD or contraindications for the use of contrast medium, especially patients with renal insufficiency. We optimized TRANCE with best performance at 3.0T and compared image quality and diagnostic accuracy versus CTA and DSA for evaluation of low extremity PAD. |
| 922 | 18:03
|
An optimised subtraction approach for subtractive NCE-MRA techniques based on principal component analysis |
1Department of Radiology, University of Cambridge, Cambridge, United Kingdom |
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An optimised subtraction approach is developed to improve the background signal suppression in subtractive Non-Contrast-Enhanced MR Angiography (NCE-MRA) and Venography (NCE-MRV) techniques. Principal component analysis (PCA) is used to correct the intensity difference of background tissue in dark-blood images (DBIs) and bright-blood images (BBIs). Compared with the direct subtraction operation, the proposed approach significantly improved the background signal suppression in all the evaluated cases including femoral Fresh Blood Imaging (FBI)-MRA, iliac Flow-Sensitive Dephasing (FSD)-MRV and FSD-MRA for the thoracic central veins. |
| S04 | Wednesday 16:15 - 18:15 | Moderators: Valentin Prevost & Jeffrey Stanley |
| 923 | 16:15
|
Correlations between quantiative myelin imaging using macromolecular proton fraction, neurogenesis, and oligodendrogenesis in the murine model of cuprizone-induced demyelination |
1Research Institute of Biology and Biophysics, Laboratory of Neurobiology, Tomsk State University, Tomsk, Russian Federation, 2Institute of Cytology and Genetics SB RAS, Novosibirsk, Russian Federation, 3Dapartment of Radiology, University of Washington, Seattle, WA, United States |
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This study aimed to identify associations between neurogenesis in the neurogenic niches, oligodendrogenesis, and myelination in the murine cuprizone demyelination/remyelination model. Myelination was quantified by the recently proposed macromolecular proton fraction (MPF) mapping method. Neurogenesis and oligodendrogenesis were assessed by immunohistology. Negative correlations were found between oligodendrogenesis and neurogenesis in both the subventricular zone and dentate gyrus. Correlation between MPF and oligodendrogenesis was also negative, whereas correlation between MPF and neurogenesis was positive. Associations between MPF and neurogenesis/oligodendrogenesis reveal the feasibility of using MPF as a surrogate marker of reparative processes in demyelinating diseases. |
| 924 | 16:27
|
Neurochemical signature of the metabolic mechanisms underlying de- & re-myelination in the mouse’s cerebellum |
1Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland, 2NORD Discovery & Translational Area, Pharmaceutical research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland, 3Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland, 4Neuroscience Center Zurich, Zurich, Switzerland |
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Because of an increasing therapeutic need to understand the underlying mechanism of myelin damage and repair in pathologies such as multiple sclerosis (MS), we used 1H-MRS to longitudinally characterize the metabolic changes in the cerebellum associated with de- and re-myelination in the cuprizone mouse model. Our results, in line with similar findings in the corpus callosum, suggest that a group of metabolites provide a unique neurochemical signature of cuprizone induced de- and re-myelination. Additionally, we observe a reversible and robust increase of GABA levels upon cuprizone feeding that goes in contradiction with current trends in clinical studies of MS patients. |
| 925 | 16:39
|
A comparison of magnetization transfer, diffusion tensor imaging and ultrashort TE measurements in a murine model of demyelination |
1Université de Strasbourg, CNRS, ICube, FMTS, Strasbourg, France, 2Institut Mines Télécom Atlantique, INSERM, LaTIM, Brest, France |
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Exploration of myelin content in the brain and spinal cord is essential for monitoring pathologies such as multiple sclerosis. Quantitative MRI methods such as diffusion tensor imaging (DTI) and quantitative magnetization transfer imaging (qMT) already demonstrated efficiency in characterizing demyelination. Ultrashort echo time sequences were previously investigated for myelin characterization within long-T2 suppression condition. In this work, we propose to compare parameters from DTI, qMT, and Diff-UTE in ex-vivo brains, using a murine model of demyelination. |
| 926 | 16:51
|
Inhomogeneous Magnetization Transfer (ihMT) sensitivity to myelin impairments in cuprizone mouse model |
1Aix Marseille Univ, CNRS, CRMBM, UMR 7339, Marseille, France, 2Aix Marseille Univ, CNRS, IBDM, UMR 7288, Marseille, France, 3Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 4Aix Marseille Univ, APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Marseille, France |
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Inhomogeneous magnetization transfer (ihMT) is a new MR imaging modality weighted by the dipolar relaxation time (T1D), which has demonstrated a strong linear correlation with myelin-specific fluorescence signal measured in genetically-modified mice, hence validating the technique as a myelin biomarker. In the current study, the ihMT sensitivity has been evaluated on a cuprizone mouse model, a widely used model of de- and remyelination. A longitudinal analysis has been performed in vivo and quantitative signal was compared to myelin amount measured by GFP quantification at remarkable time points in order to evaluate the ihMT sensitivity for monitoring in vivo myelin state. |
| 927
|
17:03
|
Are we seeing any better? A comprehensive comparison of myelin biomarkers in the healthy and multiple sclerosis post mortem spinal cord |
1Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 2Philips UK, Surrey, United Kingdom, 3Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 4Department of Anatomy and Neurosciences, VU University medical centre, Amsterdam, Netherlands, 5Department of Neurology, Haukeland University Hospital, Bergen, Norway, 6Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom, 7Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 8Brain MRI 3T Research Centre, C. Mondino National Neurological Institute, Pavia, Italy |
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Conventional MRI of the multiple sclerosis (MS) spinal cord offers low specificity to underlying pathological processes taking place. Quantitative MRI metrics able to characterize damage at the microstructural level are required. Of particular interest are those known to be sensitive to myelin content, which can be generated via various different contrast mechanisms. It is important to assess the specificity of such prospective myelin biomarkers to MS spinal cord pathology and validation studies comparing MRI with histological findings are essential for this purpose. Here a comparison of myelin-sensitive quantitative MRI metrics measured in MS and healthy ex vivo cord are presented. |
| 928 | 17:15
|
Evaluation of recovery in myelin water signal after acute ischemic stroke |
1Laboratory for Imaging Science and Technology,Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea, 2Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea |
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This study investigated the recovery in myelin water signals after acute ischemic stroke. The results showed an increase of myelin water signals in acute lesions after 3 months of treatment. Furthermore, mild stroke patients recovered more than severe stroke patients when comparing measures of myelin water signals in acute lesions. |
| 929 | 17:27
|
Neuroplastic Changes of Myelin Microstructure With Video Game Play |
1Waisman Center, University of Wisconsin Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin Madison, Madison, WI, United States, 3Psychology, University of Wisconsin Madison, Madison, WI, United States, 4Psychiatry, University of Wisconsin Madison, Madison, WI, United States |
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Mounting evidence suggests that changes in the brain can occur within hours, however, the mechanisms underlying these changes remain unknown. In this work, we utilized multicomponent relaxometry (mcDESPOT) to examine the effects of both short and long term video game playing on myelinated white matter. Short and long term changes in quantitative longitudinal relaxation times as well as long term changes of myelin water fraction were observed. These results add to the growing literature that neuroplastic effects can take place over the short term while also suggesting long term changes may involve mechanisms of myelination. |
| 930 | 17:39
|
Evidence of altered myelination in adolescents with Attention-Deficit/Hyperactivity Disorder: A multi-echo T2 imaging study |
1Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States |
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Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent childhood disorder with considerable evidence of a developmental basis for the etiology of ADHD. Structural neuroimaging studies, though limited in its interpretation, have implicated cortical and subcortical white matter in ADHD. Here we examine myelin content and axonal size/packing density in adolescents with ADHD in six white matter tracts using multi-echo T2 (ME-T2) imaging. Results show reduced myelin content as well as smaller axonal size (increased axonal packing density), which is suggestive of a lack of progressive myelination in commissural and projection tracts in ADHD. |
| 931 | 17:51
|
Myelin water fraction, diffusion tensor imaging, and g-ratio measurements characterize myelin changes in normative aging, mild cognitive impairment, and dementia |
1National Institutes of Health, Baltimore, MD, United States |
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In previous work, we showed evidence of myelin loss with mild cognitive impairment (MCI) using a direct and specific MRI measure of myelin water fraction, a surrogate for myelin content. Here, we extend this by investigating changes in myelin content in normative aging, MCI, and dementia using myelin content, diffusion tensor imaging, and g-ratio measurements. Our results showed decrease in myelin content in several brain regions of the subjects diagnosed with MCI or dementia in comparison with the old healthy subjects. Higher myelin content in middle-aged subjects was also observed, in agreement with the literature.
|
| 932
|
18:03
|
Myelin digestion during multiple sclerosis lesion formation contributes to increase on QSM |
1Weill Cornell Medicine, New York, NY, United States, 2Yale School of Medicine, New Haven, CT, United States |
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During the initial processes in the formation of MS lesions, myelin is immediately digested in macrophages after phacocytosis. Chemical bond breakdown in myelin basic proteins (MBP) and among lipid bilayers (LB) can increase magnetic susceptibility. Here we measure susceptibility increase in phantom experiments of MBP breakdown and myelin LB breakdown. We investigate myelin degradation in the first few weeks of MS lesion formation by performing histology on MS brain samples and by in vivo imaging of enhancing lesions in MS patients. |
| S05 | Wednesday 16:15 - 18:15 | Moderators: Corey Baron & Maria Altbach |
| 933
|
16:15
|
Radial streaking artifact reduction using phased array beamforming |
1Electrical and Computer Engineering, University of Arizona, Tucson, AZ, United States, 2Department of Medical Imaging, University of Arizona, Tucson, AZ, United States |
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Streaking artifacts can occur in radial MR imaging especially in applications that require large FOVs. In abdomen MRI, the common sources of streaking are unsuppressed fat and the arms with the latter being a particularly problematic source of streaking. The standard approach to mitigate streaking is to identify, either manually or automatically, the subset of coils that are heavily contaminated by streaking artifacts and discard them prior to coil-combination. We present a simple approach to mitigate streaking artifacts that leverages phased array beamforming (spatial filtering) and demonstrate its performance on radial fast spin echo data. |
| 934 | 16:27
|
k-space Diagonal Preconditioner: Speeding Up Iterative Reconstruction For Variable Density Sampled Acquisitions Without Compromises |
1University of California, Berkeley, Berkeley, CA, United States, 2Institute for Diagnostic and Interventional Radiology, University Medical Center Göttingen, Göttingen, Germany, 3German Centre for Cardiovascular Research (DZHK), Gottingen, Germany |
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Variable density sampling is now commonly used in advanced imaging methods. However, due to ill conditioning, reconstruction can take hundreds of iterations, limiting its clinical application. One effective heuristic to accelerate convergence is the use of density compensation, but it is known to increase reconstruction error. An alternative is to use preconditioners, but existing preconditioners increase computation by performing additional image convolutions. Our goal here is to accelerate iterative reconstruction convergence without compromises. We propose a k-space diagonal preconditioner, without compromising reconstruction error, or computation. We demonstrate on datasets that reconstructions with the proposed preconditioner converge at around 10 iterations. |
| 935 | 16:39
|
Accelerated Spiral imaging for Real-time Cardiac MRI |
1Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States |
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This study proposes two spiral-based (spiral-out and spiral-in/out) bSSFP pulse sequences combined with two reconstruction methods for accelerated real-time cardiac imaging. Based on a comparison to fully-sampled data reconstructed using gridding, a low rank plus sparse (L&S) method performs better than a CG-SPIRiT method on both spiral trajectories. The spiral-in/out sequence achieved higher SNR and fewer artifacts than the spiral-out sequence. Thus, a spiral-in/out bSSFP sequence with L&S reconstruction is a promising method for real-time cardiac MRI with high image quality and excellent temporal resolution. |
| 936 | 16:51
|
Spiral Imaging on a Compact 3T Scanner with High Performance Gradients |
1Radiology, Mayo Clinic, Rochester, MN, United States |
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Recently, a low-cryogen, compact 3T MRI system optimized for brain, extremity and infant imaging was developed. The system is equipped with a high slew rate gradient capable of 80 mT/m maximum gradient amplitude and 700 T/m/s slew rate. Due to its reduced imaging volume (26-cm diameter-spherical-volume), the high gradient amplitude and slew rate can be achieved simultaneously on this system with substantially less peripheral nerve stimulation. Here, we investigate the benefit of performing spiral imaging using high gradient performance available on this system. We demonstrated that the high slew-rate can significantly reduce spiral readout time and therefore reduce off-resonance-induced blurring. |
| 937 | 17:03
|
Highly-accelerated volumetric brain protocol using optimized Wave-CAIPI encoding |
1Department of Physics and Astronomy, Heidelberg University, Heidelberg, Germany, 2Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 3Siemens Healthcare GmbH, Erlangen, Germany, 4Harvard Medical School, Boston, MA, United States, 5Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, 6Department of Radiology, Massachusetts General Hospital, Boston, MA, United States |
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We introduce an optimized six-minute high-resolution whole-brain protocol of 3D, mainly isotropic acquisitions for T2w SPACE, FLAIR (3D), T1w MPRAGE and T2*w SWI; all acquired at 9-fold acceleration using Wave-CAIPI encoding. Design strategies were developed to optimize wave-encoding parameter selection, coil sensitivity computation, and data-driven automated gradient trajectory error estimation. We validated our exam on five volunteers on a 3T MRI scanner and achieved good SNR with negligible g-factor noise and good image contrast despite the 9-fold acceleration. Our fast high-resolution neurological exam should benefit several clinical and research applications and help mitigate patient compliance issues and motion artifacts. |
| 938
|
17:15
|
GRAPPA Reconstructed 3D Wave-CAIPI TSE at 7 Tesla |
1German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 2Department of Physics and Astronomy, University of Bonn, Bonn, Germany |
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In this work, wave-CAIPI sampling is incorporated in a 3D variable flip angle turbo spin echo (TSE) sequence optimized for ultra high field applications. The acquired wave-CAIPI data are reconstructed with a GRAPPA-based wave-CAIPI reconstruction algorithm using multiple reconstruction kernels. Highly accelerated wave-CAIPI TSE images with 1 mm3 resolution and whole brain coverage are acquired at a 7 Tesla scanner. A clear SNR improvement compared to Cartesian CAIPIRINHA is shown. |
| 939 | 17:27
|
Self-calibrating Wave-encoded 3D Turbo Spin Echo Imaging using Subspace Model based Autofocus |
1Philips Research North America, Cambridge, MA, United States, 2Vascular Imaging Lab, Department of Radiology, University of Washington, Seattle, WA, United States, 3Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, 4Philips Research Hamburg, Hamburg, Germany |
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Wave-encoding techniques can better utilize the three-dimensional (3D) encoding power of parallel imaging (PI) during acquisition and image reconstruction, but proper calibration of wave point spread function (PSF) and coil sensitivities are required. In this study, a self-calibrating wave PSF and PI kernel approach from subsampled wave-encoded k-space is proposed using subspace model based autofocus estimation. Its performance is evaluated for 3D wave encoded turbo spin echo (TSE) imaging. The preliminary results on phantom has demonstrated the calibration accuracy of self-calibrated wave PSF and improved PI performance in comparison to Cartesian based PI for 3D TSE imaging. |
| 940 | 17:39
|
Joint SENSE Reconstruction for Faster Multi-Contrast Wave Encoding |
1Martinos Center for Biomedical Imaging, Charlestown, MA, United States |
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We introduce Joint SENSE acquisition/reconstruction to provide higher acceleration in multi-contrast acquisitions with improved image quality. We employ a complementary sampling strategy by shifting the k-space sampling patterns across the contrasts, which induces phase ramps in image space. By harnessing these ramps as additional coil sensitivity variations, we improve reconstruction error and g-factor performance by >2x compared to standard SENSE reconstruction. Further, we combine Joint SENSE with Wave encoding to exploit 4-dimensional sensitivity encoding, 3D across space + 1D across contrasts, to provide rapid multi-contrast acquisition with high quality. |
| 941 | 17:51
|
Trajectory correction for a 3D-Ultrashort Echo Time (UTE) sequence using the gradient system transfer function |
1Department of Diagnostic and Interventional Radiology, University Hospital of Würzburg, Würzburg, Germany, 2X-Ray and Molecular Imaging Laboratory, Ostbayerische Technische Hochschule Amberg-Weiden, Weiden, Germany |
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3D-Ultrashort Echo Time (UTE) sequences with 3D-kossh ball trajectory suffer from k-space trajectory deviations and ghosting artifacts due to hardware imperfections. The gradient system transfer function (GSTF), completely characterizes the gradient system as a linear and time-invariant (LTI) system. In this study, the GSTF was measured only using standard scanner hardware and was used to correct deviated trajectories in image reconstruction. This results in diminished ghosting artifacts and improve image quality. |
| 942 | 18:03
|
Cross Term and Higher Order Gradient Impulse Response Function Characterization using a Phantom-based Measurement |
1Philips GmbH Innovative Technologies Research Laboratories Hamburg, Hamburg, Germany |
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Characterization of the 3D field response of an MRI gradient system is important for proper system calibration. A powerful approach to 3D characterization is the acquisition of the gradient impulse response function (GIRF) using a set of distributed MRI probes. An alternative approach is the phantom-based measurement of the GIRF using a thin slice method. However, this method currently only delivers 0th order information (ΔB0) and 1st order direct terms (Gxx, Gyy, Gzz), but no cross terms (e.g. Gxy) or higher order information. We present an extension of the thin slice method by adding phase encoding for characterization of 1st order cross terms as well as higher order spatial components. Experimental results on the respective gradient modulation transfer functions (GMTFs) of a clinical system are presented. |
| S06 | Wednesday 16:15 - 18:15 | Moderators: Michael Garwood & Clarissa Cooley |
| 943
|
16:15
|
A 6.3kg Single-Sided Magnet for 3D, Point-of-Care Brain Imaging |
1Massachusetts Institute of Technology, Cambridge, MA, United States, 2Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 3Harvard Medical School, Boston, MA, United States |
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MRI, as currently used, requires transporting the patient to the scanner. A truly point-of-care MRI device, possibly even hand-held, could increase the utility of MRI extending its reach and enabling new applications, such as continuous bedside monitoring. In this work, we design and construct a light-weight (6.3kg), single-sided permanent magnet designed to image the cortical region it is positioned over (~8cm x 8cm x 3cm ROI). We describe the magnet optimization and compare the predicted and measured B0 field pattern and validate its imaging potential by acquiring 1D depth profiles in a phantom. |
| 944 | 16:27
|
Rotatable Main Field MRI Scanner for Angle Sensitive Imaging |
1Mechanical Engineering, Imperial College London, London, United Kingdom, 2Electrical Engineering, Imperial College London, London, United Kingdom |
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Anisotropies with respect to the main field direction in collagen-rich tissues may be exploited to provide new information about the tissue microstructures. However this requires the field to be oriented at various oblique angles relative to the subject. This is usually difficult and often impossible using conventional MRI magnet configurations. We have developed an entirely new open magnet concept which can be rotated about two motorised axes to achieve a wide range of orientations. The design of the magnet and the gradients posed special challenges. The new MRI system is suitable for imaging of extremities, particularly the knee. |
| 945 | 16:39
|
MRI Compatible Hypobaric Chamber to study Early Aeromedical Evacuation Following Traumatic Brain Injury |
1Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2Department of Anesthesiology and the Center for Shock Trauma and Anesthesiology Research, University of Maryland School of Medicine, Baltimore, MD, United States |
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Combat-related TBI leads to significant mortality and morbidity. In our previous research, we have demonstrated that simulated aeromedical evacuation (AE), or hypobaria, worsens neurological outcomes after TBI and suggests that early AE of TBI patients contributes to secondary insults. To study the effects of such hypobaric exposure during early stage of injury we have constructed a MRI compatible hypobaric chamber that allows us to evaluate changes in metabolism, perfusion, and functional status in a preclinical model of brain injury. Here we demonstrate our initial experiences with the hypobaric chamber in the MRI to obtain in vivo imaging and spectroscopic data. |
| 946
|
16:51
|
Joint dynamic shimming using the scanner’s spherical harmonic shim combined with a local multi-coil shim array |
1Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2IMPRS for Cognitive and Systems Neuroscience, University of Tuebingen, Tuebingen, Germany, 3Skope Magnetic Resonance Technologies AG, Zurich, Switzerland, 4Department of Biomedical Magnetic Resonance, University of Tuebingen, Tuebingen, Germany |
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In this work, we combined scanner's spherical harmonic shim coils with a local multi-coil shim array to work in parallel for dynamic shimming of the human brain at 9.4 T. Performance of the combined method is compared with global shimming with scanner's built-in shim setup, global shimming with multi-coil and dynamic shimming with multi-coil. |
| 947 | 17:03
|
Direct Generation of MR Images in a Divergent Coordinate System for MRI Radiotherapy Hybrids |
1Medical Physics, Oncology, University of Alberta, Edmonton, AB, Canada, 2Medical Physics, Cross Cancer Institute, Edmonton, AB, Canada |
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The direct generation of images in a divergent coordinate system may be important to some applications of MR imaging in MRI-radiotherapy hybrids. Specifically, in the circumstance where 2D images are being used for real-time therapy beam guidance, image generation in a divergent coordinate system that matches that of the treatment beam (which originates from a single source point) will reduce targeting errors and inadvertent dosing of critical structures. This work presents a theoretical hardware solution to a variety of MRI-radiotherapy implementations which involve the replacement or augmentation of conventional linear gradients. An experimental and simulated verification is presented. |
| 948 | 17:15
|
A low-cost (<$500 USD) FPGA-based console capable of real-time control |
1Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3A. A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States |
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Conventional MRI consoles are high-cost and difficult to customize, typically using a proprietary language for creating pulse sequences. Recently, FPGAs have become the tool of choice in designing custom MRI consoles for their flexibility and speed. In this work, we describe a low-cost, open source, FPGA-based console using an off-the-shelf board that provides flexibility in pulse-sequence programming, robust timing, and excellent signal stability. Our goal is to facilitate the development of custom acquisition methods and provide a useful console for MR education and low-cost systems. We demonstrate its function by acquiring a 2D spin-echo image on an MIT/Martinos Tabletop scanner. |
| 949 | 17:27
|
Ex vivo continuous Overhauser nuclear dynamic polarization in a SQUID-based ultralow field magnetic resonance imaging system |
1High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2Physikalisches Institut and Center for Quantum Science (CQ) in LISA+, Eberhard Karls Universität, Tübingen, Germany |
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Overhauser Dynamic Nuclear Polarization (ODNP) is a method to achieve continuous hyperpolarization in MR measurements. Here, the polarization of free radicals is transferred to 1H using High Frequency (HF) pulses at the electron Larmor frequency. At UltraLow Fields (ULF) the frequency of the HF pulse lies in the range of several 100 MHz and is able to penetrate large sample volumes, making continuous in vivo ODNP measurements possible. Since conventional Faraday coils are not sensitive enough at ULF, a Superconducting QUantum Interference Device (SQUID) based detector is employed. First ex vivo images using ODNP enhanced MR have been acquired successfully. |
| 950 | 17:39
|
Advanced Gradient Driver Design with Silicon Carbide MOSFETs |
1GE Global Research Center, Niskayuna, NY, United States, 2GE Global Research, Bangalore, India, 3GE Global Research, Niskayuna, NY, United States |
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In a MRI system, gradient driver is a switching power supply which is composed of power semiconductor devices, such as insulated gate bipolar transistors (IGBTs), power metal oxide semiconductor field effect transistor (MOSFET), etc. To control an electrical power that can be transferred by the gradient driver, the power semiconductor devices are usually operated in a pulse width modulation (PWM) method with high voltage, high current and high switching frequency [1-4]. With advanced semiconductor devices like silicon carbide devices, each module could sustain higher voltage which will simplify the power supply architecture. Meanwhile, the fast switching capability of Silicon Carbide (SiC) devices make the gradient amplifier more efficient than silicon version. This paper presented a high performance modular solution gradient amplifier system with advanced wide-band gap SiC devices. Image test with the advanced gradient driver was demonstrated in this paper. |
| 951 | 17:51
|
High-performance portable spin-exchange optical pumping polarizer for hyperpolarized 129Xe MRI |
1University of Sheffield, Sheffield, United Kingdom |
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There is increasing interest in hyperpolarized (HP) 129Xe MRI for research and clinical imaging questions in the lungs and other organs where dissolved xenon can be used to assess tissue perfusion. With the motivation of increasing the availability of HP 129Xe technology we undertook to design and build a portable 129Xe polarizer. We demonstrate here a compact portable 129Xe polarizer capable of generating 129Xe polarized to ~35% at a production rate of 1.8 L/h. The polarizer is entirely self-contained, requiring only mains electricity at the site of interest. |
| 952 | 18:03
|
Multiscale measurement of the effects of glucose starvation on 4T1 murine breast cancer cells using an MRI and optical microscopy compatible bioreactor |
1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 2Morgridge Institute for Research, Madison, WI, United States, 3Laboratory for Optical and Computational Instrumentation (LOCI), University of Wisconsin - Madison, Madison, WI, United States, 4Cell and Regenerative Biology, University of Wisconsin - Madison, Madison, WI, United States, 5Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, 6Radiology, University of Wisconsin - Madison, Madison, WI, United States |
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The design and application of a novel bioreactor capable of facilitating both magnetic resonance spectroscopy (MRS) and optical fluorescence microscopy for complementary metabolic information is described. Fluorescence lifetime imaging (FLIM) of nicotinamide adenine dinucleotide (NADH) and hyperpolarized [1-13C] pyruvic acid (PA) MRS were performed on 3D cell cultures of 4T1 murine breast cancer cells to study the effects of glucose starvation across cellular and population scales. The system provides a novel test-bed for simulating cell-matrix and cell-cell interactions in a 3D microenvironment for investigating multi-scale cellular metabolism in vitro. |
| W03/04 | Wednesday 16:15 - 18:15 | Moderators: Meiyun Wang & Sammy Badr |
| 953 | 16:15
|
Selective Size Imaging using Filters via diffusion Times (SSIFT): A new contrast-free highly-specific MR cancer imaging method |
1radiology and radiological sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 2Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN, United States, 3Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States |
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We propose a novel, exogenous-agent-free, highly-specific, and high-resolution cancer imaging technique termed SSIFT. Based on different diffusion time dependence on length scales, SSIFT creates filters via appropriately chosen diffusion times to selectively enhance detection sensitivity to cancer cells with simultaneous suppression of sensitivity to normal brain cells, vasogenic edema, and cystic fluid. In the first applications in metastatic brain cancer patients, SSIFT is capable of significantly enhancing tumor conspicuity and delineation, and more importantly capable of differentiating tumor recurrence from radionecrosis, which is not reliably achievable by current MRI methods. |
| 954 | 16:27
|
Tumor microenvironment (TME) mapping: MRI of intratumoral heterogeneity of oxygen metabolism and neovascularization uncovers two survival relevant subgroups of IDH1 wild-type glioblastoma |
1Department of Neurosurgery, University of Erlangen-Nürnberg, Erlangen, Germany, 2Institute of Medical Radiology, University Clinic of St. Pölten, St. Pölten, Austria, 3Department of Neuroradiology, University of Erlangen-Nürnberg, Erlangen, Germany, 4Department of Neuropathology, University of Erlangen-Nürnberg, Erlangen, Germany, 5Department of Neurology, University Clinic of St. Pölten, St. Pölten, Austria |
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The dismal prognosis of glioblastoma is largely attributed to hypoxic and perivascular niches in the tumor microenvironment (TME) which are essential for elucidation of pathophysiological mechanisms behind therapy resistance and recurrence. Here, we combined MRI biomarkers for oxygen metabolism and neovascularization with an automatic classification strategy for localization of hypoxic and vascular niches within the heterogeneously structured TME. Correlation with the metabolic pathway for energy production uncovered two different phenotypes for glioblastoma IDH1wt: A glycolytic phenotype with stable functional neovasculature, and a necrotic/hypoxic phenotype with defective neovasculature and a more aggressive tumor behavior. The glycolytic phenotype showed longer progression-free survival. |
| 955 | 16:39
|
Magnetic Resonance Spectroscopic Differences of Diffuse Glioma Groups Classified by IDH and TERT Promoter Mutations at 3T |
1Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, 2Department of Medical Engineering, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 3Neuroradiology Research Center, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 4Department of Molecular Biology and Genetics, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 5Department of Neurosurgery, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 6Department of Radiology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey |
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Overall survival of gliomas has been reported to be highly associated with the presence of isocitrate dehydrogenase (IDH) and telomerase reverse transcriptase (TERT) promoter mutations. The aim of this study is to define MR spectroscopic (MRS) differences of diffuse glioma subgroups classified by IDH and TERT promoter mutations at 3T. TERT-only mutated and TERT wild type IDH wild type (TW-IDHW) gliomas had similar metabolic profiles. Besides well-reported 2HG, our study indicated the importance of glycine, glutathione, glutamate, and glutamine in identification of IDH-mutant gliomas. TERT-only gliomas had the highest glutamate and glutathione, which might be indicators of poor overall survival. |
| 956 | 16:51
|
Magnetic Resonance Spectroscopy markers of survival in paediatric brain tumours: A 3T Multi-Centre investigation |
1University of Birmingham, Birmingham, United Kingdom, 2Birmingham children's hospital, Birmingham, United Kingdom, 3Department of Radiology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom, 4Institute of Digital Healthcare, WMG, University of Warwick, Coventry, United Kingdom, 5Paediatric Oncology Department, Great North Children’s Hospital, Newcastle upon Tyne, United Kingdom, 6Department of Imaging and Medical Physics, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, 7The Children‘s Brain Tumour Research Centre, University of Nottingham, Nottingham, United Kingdom, 8Radiological Sciences, Department of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom, 9Medical Physics, Nottingham University Hospital, Queen’s Medical Centre, Nottingham, United Kingdom, 10Neuroradiology, Nottingham University Hospital, Queen’s Medical Centre, Nottingham, United Kingdom, 11Neuroradiology Department, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom, 12Department of Paediatric Oncology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom |
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Brain tumours have a high mortality rate and are the most common solid tumour of childhood. The non-invasive imaging technique, MRS, measures tumour metabolites which can provide additional prognostic information to aid in clinical management. MRS metabolites Glycine, Scyllo-Inositol, NAA and Lipids have been associated with prognosis for pediatric brain tumour patients in a single centre 1.5T study. This study aimed to validate these MRS survival markers in a 3T multicentre setting. In this preliminary study Lipids were validated as a survival marker across childhood brain tumours. |
| 957
|
17:03
|
RADIOMIC ANALYSIS OF 3D MR FINGERPRINTING IN ADULT BRAIN TUMORS |
1Case Western Reserve University, Cleveland, OH, United States, 2University Hospitals Cleveland Medical Center, Cleveland, OH, United States |
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Though conventional and advanced MR imaging studies such as perfusion and MR spectroscopy are useful for evaluating brain tumors, there remains a need for a rapid, quantitative, and non-invasive method. Magnetic Resonance Fingerprinting (MRF) utilizes pseudo-randomized acquisition parameters to simultaneously quantify multiple tissue properties including T1 and T2 relaxation times. A previous 2D MRF study quantitatively differentiated between solid tumor and peri-tumoral white matter regions of various brain tumors. In this ongoing study we demonstrate the capability of volumetric 3D MRF to improve lesion characterization between adult intra-axial brain neoplasms using first- and second- order radiomic analysis. |
| 958 | 17:15
|
Whole-Tumor Histogram and Texture Analyses of Diffusion Tensor Imaging for Evaluation of IDH1 Mutation and 1p/19q Codeletion Status in WHO grade II gliomas |
1Radiology, Ewha Womans University College of Medicine, Seoul, Republic of Korea, 2Yonsei University College of Medicine, Seoul, Republic of Korea |
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We analyzed the histogram and texture features of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) based on entire tumor to determine isocitrate dehydrogenase 1 (IDH1) mutation and 1p/19q codeletion status in WHO grade II gliomas. Regions of interest were drawn on ADC and FA maps of 93 grade II gliomas. Histogram and texture analyses were performed. The areas under the curve (AUC) for IDH1-wildtype prediction was 0.853, and AUC for 1p/19q codeletion prediction was 0.807. The whole-tumor histogram and texture features of ADC and FA maps are useful in predicting the molecular status in WHO grade II gliomas. |
| 959
|
17:27
|
Integrated vascular (iVas) MRI in brain tumors |
1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Graduate School of Biomedical Sciences, UT Southwestern Medical Center, Dallas, TX, United States, 3Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States |
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Perfusion and functional MRI, yielding markers such as cerebral blood volume, cerebrovascular reactivity, and functional connectivity, play an important role in the diagnosis and treatment of brain tumors. However, a major limitation is that collection of all this information requires separate scans and, in some cases, separate visits. Here we applied a novel iVas-MRI technique that provides quantitative assessment of multiple hemodynamic parameters and functional connectivity in a single scan of 9 minutes. It was found that the multi-parametric maps can reliably differentiate tumor from normal tissue and can further predict tumor grade. |
| 960 | 17:39
|
Radiomics utilizing Fractional Anisotropy in Peritumoral Nonenhancing Region Predicts Local Progression and Overall Survival in Patients with Glioblastoma |
1Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea, 2Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea |
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We explored the radiomic features of peritumoral nonenhancing lesion in newly diagnosed glioblastoma patients to predict local progression and overall survival using fractional anisotropy (FA) at 3 Tesla. Among 1618 extracted radiomic features, 8 FA features were significantly associated with 6-month progression and overall survival (OS). The cross-validated area under the ROC curve (AUC) for 6-month progression was 0.71 and C-index for OS was 0.75. FA radiomics in nonenhancing lesion has the potential for predicting local progression and overall survival in glioblastoma. |
| 961 | 17:51
|
Simultaneous pH- and oxygen-weighted metabolic MRI of human gliomas at 3T using multi-echo amine proton chemical exchange saturation transfer spin-and-gradient-echo echoplanar imaging (CEST-SAGE-EPI) |
1Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, 2Neurology, University of California Los Angeles, Los Angeles, CA, United States, 3Neurosurgery, University of California Los Angeles, Los Angeles, CA, United States |
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Glycolysis is enhanced in cancers, even in the presence of abundant oxygen, leading to accumulation of lactic acid. We present a technique for fast pH- and oxygen-weighted MR imaging using multi-echo amine proton chemical exchange saturation transfer echo spin-and-gradient echoplanar imaging (CEST-SAGE-EPI) on a clinical 3T MRI system. In phantom and human experiments, we investigate the ability to simultaneously measure MTRasym at 3ppm, a measure dependent on pH, and R2’, which is sensitive to oxygen extraction. Results suggest T2 hyperintense tumor is acidic, but not hypoxic; whereas contrast enhancing tumor is acidic and hypoxic, consistent with known cancer biology. |
| 962
|
18:03
|
Grading Brain Tumor Using ADC as a Marker of Cellularity: Fact or Fiction |
1Radiology, Washington University School of Medicine, St. Louis, MO, United States, 2Neurological Surgery, Washington University School of Medicine, St. Louis, MO, United States, 3Biostatistics, Washington University School of Medicine, St. Louis, MO, United States, 4Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States |
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Here we demonstrate that ADC is not a reliable imaging biomarker of tumor cellularity in high grade glioma since ADC does not consistently correlate with histology determined tumor cellularity. In contrast, diffusion MRI Histology (D-Histo) derived restricted isotropic diffusion fraction demonstrated a significantly positive correlation with histology determined cellularity in high grade glioma. |
| W05/06 | Wednesday 16:15 - 18:15 | Moderators: Talissa Altes & Sean Fain |
| 963
|
16:15
|
Spectroscopic Imaging of Dissolved-phase 129Xe in the Lungs Using a 3-Resonance Model |
1Department of Medical Physics, University of Wisconsin, Madison, Madison, WI, United States, 2Department of Radiology, Duke University Medical Center, Durham, NC, United States, 3Department of Biomedical Engineering, Duke University, Durham, NC, United States |
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Spectroscopic imaging of the hyperpolarized xenon-129 dissolved in the pulmonary tissues and blood can probe regional gas exchange within the lung. Recent work in whole lung spectroscopy has identified a new, third resonance in the dissolved-phase spectrum. In this work, we develop an iterative, model based reconstruction to separately image the three dissolved-phase components. Regional maps of the three dissolved-phase components are compared in healthy subjects and patients with idiopathic pulmonary fibrosis. |
| 964
|
16:27
|
Hyperpolarized 129Xe Multiple Breath Washout MRI in Pediatric Cystic Fibrosis |
1Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada |
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The lung clearance index, measured using N2 multiple breath washout (MBW), provides an indicator of ventilation heterogeneity but lacks regional information. The combination of MBW and hyperpolarized 129Xe MRI can potentially provide measurements of ventilation heterogeneity that include both spatial and temporal information. MBW imaging was performed following an initial 129Xe inhalation and during multiple breath-holds of room air to measure the 129Xe washout. Fractional ventilation and coefficient of variation maps measured in pediatric cystic fibrosis participants show elevated ventilation heterogeneity compared to age-matched healthy controls. |
| 965
|
16:39
|
Emphysema Index based on Hyperpolarized He-3 and Xe-129 ADC |
1Physics, University of Virginia, Charlottesville, VA, United States, 2Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 3Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States, 4Medicine, University of Virginia, Charlottesville, VA, United States, 5Radiology, University of Missouri, Columbia, MO, United States |
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Emphysema index (EI) based on CT provides a quantitative measure of emphysema burden in patients with chronic obstructive pulmonary disease (COPD). Diffusion-weighted MRI of inhaled hyperpolarized gases also provides a method for detecting emphysema, as elevated ADC values indicate airspace enlargement due to emphysematous destruction of alveolar walls. We propose an alternative formulation of EI based on He-3 or Xe-129 ADC measurements and compare their performance in characterizing emphysema severity with that of CT-EI. Our results suggest that ADC-EI may provide a useful quantitative measure of emphysema burden in patients with COPD that is more sensitive to early stages of emphysema than CT-EI. |
| 966 | 16:51
|
Hyperpolarized 129Xe MR spectroscopy detects short-term changes in lung gas exchange efficiency in idiopathic pulmonary fibrosis |
1University of Sheffield, Sheffield, United Kingdom, 2Sheffield Teaching Hospitals, Sheffield, United Kingdom, 3Sheffield Children's Hospital NHS Foundation Trust, Sheffield, United Kingdom |
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Idiopathic pulmonary fibrosis (IPF), once thought of as an orphan lung disease, is now a frontrunner in respiratory research. However, progress is hampered by a lack of sensitive biomarkers. Hyperpolarized xenon MR spectroscopy has demonstrated sensitivity to gas exchange in IPF and is emerging as a feasible imaging biomarker of disease. Here, we demonstrate that this methodology has high reproducibility in the disease state, correlates with clinical outcomes and demonstrates a decline in gas transfer efficiency in the lung over six months in spite of static pulmonary function test metrics. |
| 967 | 17:03
|
Hyperpolarized 129Xe Gas Exchange MRI: The Transition from 1.5 to 3 Tesla |
1Biomedical Engineering, Duke University, Durham, NC, United States, 2Electrical and Computer Engineering, Duke University, Durham, NC, United States, 3Medical Physics Graduate Program, Duke University, Durham, NC, United States, 4Radiology, Duke University Medical Center, Durham, NC, United States, 5Division of Cardiology, Duke University Medical Center, Durham, NC, United States, 6Division of Pulmonary, Allergy and Critical Care, Duke University Medical Center, Durham, NC, United States |
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Hyperpolarized 129Xe is uniquely suited to imaging pulmonary functions by virtue of its solubility and abundant chemical shifts. Previous efforts established single-breath 3D imaging of 129Xe ventilation, barrier uptake and RBC transfer at 1.5 Tesla. As MR vendors are increasingly transitioning their multinuclear platforms to 3 Tesla, it becomes important to enable 129Xe gas exchange MRI at higher field strengths. Here we demonstrate that by careful measurement of spectral properties and optimization of RF and readout, short T2* can be overcome, and 129Xe gas exchange MRI with quantitative workflow is feasible and robust at 3 Tesla. |
| 968 | 17:15
|
Measurements of human brown adipose tissue temperature during cold exposure by hyperpolarized xenon MR thermometry |
1Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 3Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 4Dept of Emergency Medicine, Exercise and Sports Science, University of North Carolina school of medicine, Chapel Hill, NC, United States |
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While temperature measurement represents the most direct way to measure BAT thermogenic function, temperature measurements by proton-based MR methods are confounded by magnetic susceptibility effects, which cannot be corrected for at the microscopic level. Here we report our first measurements of absolute BAT temperature in adult humans during cold exposure by hyperpolarized xenon gas MRI. These measurements represent the most direct way to measure thermogenic function in BAT. |
| 969 | 17:27
|
Correlating 129Xe Gas Exchange MRI with 99mTc Perfusion Scintigraphy |
1Biomedical Engineering, Duke University, Durham, NC, United States, 2Medical Physics Graduate Program, Duke University, Durham, NC, United States, 3Radiology, Duke University Medical Center, Durham, NC, United States, 4Division of Cardiology, Duke University Medical Center, Durham, NC, United States |
||
Hyperpolarized 129Xe MRI is emerging as a unique means of imaging pulmonary gas exchange, enabling separate 3D encoding of 129Xe in the gas-phase, interstitial barrier, and red blood cells (RBC). In patients where diffusion limitation is not significant, defects in RBC transfer and perfusion deficits should more closely reflect diminished capillary blood volume or perfusion limitation. Here we establish an initial approach to correlate RBC transfer images against an accepted perfusion imaging reference— 99mTc scintigraphy. We demonstrate in patients with pulmonary arterial hypertension and COPD that RBC transfer projections compare both qualitatively and quantitatively with 99mTc scintigraphy. |
| 970 | 17:39
|
An integrated preclinical platform for high-resolution 3D hyperpolarized 129Xe MRI at high field |
1Biomedical Engineering, Duke University, Durham, NC, United States, 2Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States, 3Radiology, Duke University Medical Center, Durham, NC, United States |
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Hyperpolarized (HP) 129Xe MR imaging of lung function is beginning to find clinical application. This must be supported by preclinical imaging in well-characterized animal models. However, this capability is limited to a few sites, often involves only 2D projections, and is often done at non-standard, low field strengths. This work demonstrates the feasibility of preclinical 129Xe MRI at 7T, using an integrated gas delivery and physiological monitoring system and customized 3D radial acquisitions. We characterize the spectral structure of 129Xe in rats and demonstrate that despite the short T2* at high field strength, 3D gas exchange imaging should be feasible. |
| 971 | 17:51
|
In Vivo Hyperpolarized 129Xe Diffusion Morphometry of the Mouse Lung |
1Center for Pulmonary Imaging Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 2Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States, 3Department of Physics, West Texas A&M University, Canyon, TX, United States, 4Department of Radiology, Washington University School of Medicine, St. Louis, MO, United States, 5Division of Critical Care Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States |
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Hyperpolarized 129Xe diffusion morphometry allows the microstructural dimensions of the lungs to be measured noninvasively, providing a means to quantify normal alveolar growth and disease progression in disorders such as emphysema. In the preclinical setting, 129Xe diffusion morphometry holds the potential to provide insights into fundamental pulmonary biology and to assess the efficacy of potential therapies. However, to have the greatest impact on pulmonary biomedicine, this approach must be applied reliably to mouse models, where tools to investigate disease mechanisms are most highly developed. Here, we demonstrate the feasibility of high-resolution, 129Xe diffusion morphometry in living mice. |
| 972 | 18:03
|
Dependence of the Chemical Shift of 129Xe Dissolved in Red Blood Cells on Transit Time from the Lung Gas Exchange Region in Rats |
1Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Medical Imaging, University of Toronto, Toronto, ON, Canada |
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The chemical shift of 129Xe dissolved in red blood cells was measured at increasing transit times from the gas exchange region of the lungs of healthy rats and rats exposed to hyperoxia/hypoxia, a model of bronchopulmonary dysplasia. The results show that the chemical shift decreased with increasing transit times. Furthermore, the chemical shift was different between the healthy and exposed cohorts. A possible mechanism for this phenomenon based on changes in bulk magnetic susceptibility distal to the lungs is proposed. |
| W07 | Wednesday 17:15 - 18:15 | (no CME credit) |
| W05/06 | Wednesday 18:30 - 19:30 | (no CME credit) |
| N03 | Wednesday 19:30 - 21:30 | (no CME credit) |
Organizers: Stephan Maier, Jennifer McNab, Noam Shemesh
| N03 | Thursday 7:00 - 7:50 | Moderators: Rebecca Feldman & Grant Yang |
| 7:00 | Human Diffusion Imaging at UHF |
| Daniel Gallichan |
| 7:25 | Animal Diffusion Imaging UHF |
| Hao Huang |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Jongho Lee, Utaroh Motosugi, Yi-Fen Yen
| N04 | Thursday 7:00 - 7:50 | Moderators: Utaroh Motosugi & Yi-Fen Yen |
| 7:00 | An introduction to Synthetic MRI |
| Marcel Warntjes |
| 7:25 | Clinical Applications of Synthetic MR |
| Masaaki Hori |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Kathryn Fowler, Kartik Jhaveri, Catherine Hines, Lorenzo Mannelli, Valeria Panebianco, Scott Reeder, Reiko Woodhams
| S01 | Thursday 7:00 - 7:50 | Moderators: Byung Choi & Vikas Gulani |
| 7:00 | Primary Liver Cancer Response |
| Richard Do |
| 7:25 | Metastatic Disease Response |
| Dow-Mu Koh |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Sebastian Kozerke, Reza Nezafat
| S02 | Thursday 7:00 - 7:50 | Moderators: Emilie Bollache & Jennifer Steeden |
| 7:00 | Intracardiac flow - where we are and where we want to be |
| Malenka Bissell |
| 7:25 | Probing Flow Energetics |
| Belén Casas |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Guanshu Liu, Natalie Serkova, Damian Tyler
| S03 | Thursday 7:00 - 7:50 | Moderators: Guanshu Liu & Damian Tyler |
| 7:00 | Recent Technical Developments of Molecular Imaging for Body Imaging |
| Kevin Bennett |
| 7:25 | Clinical Translation & Applications of Molecular MRI in Body Imaging |
| Tone Bathen |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Eric Chang, Garry Gold, Emily McWalter, Edwin Oei, Philip Robinson
| S04 | Thursday 7:00 - 7:50 | Moderators: Martijn Froeling & Kimberly Amrami |
| 7:00 | UTE MRI of Tendons, Ligaments & Meniscus |
| Akshay Chaudhari |
| 7:25 | Clinical Imaging of Tendons, Ligaments, Meniscus with Emerging MR Methods |
| Richard Hodgson |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Andre Obenaus, Pia Maly Sundgren
| S05 | Thursday 7:00 - 7:50 | Moderators: Patricia Grant & Robert Witte |
| 7:00 | Nicotine & the Brain |
| Minming Zhang |
| 7:25 | Your Brain on Drugs : Neuroimaging of Illicit Substance Abuse |
| Cheng-Yu Chen |
| 7:50 | Adjournment & Meet the Teachers |
Organizers: Gregor Adriany, Matthias Günther, Michael Hansen, Christoph Juchem, Greig Scott
| S06 | Thursday 7:00 - 7:50 | Moderators: Christoph Juchem & Greig Scott |
| 7:00 | Making Quality Software |
| William Overall |
| 7:25 | Open Source Acquisition & Reconstruction Software |
| Stefan Kroboth |
| 7:50 | Adjournment & Meet the Teachers |
| Exhibition Hall 2627-2647 | Thursday 8:00 - 10:00 | (no CME credit) |
| Exhibition Hall 2648-2660 | Thursday 8:00 - 10:00 | (no CME credit) |
| Exhibition Hall | Thursday 8:00 - 9:00 | (no CME credit) |
| Exhibition Hall | Thursday 8:00 - 9:00 | (no CME credit) |
| W07 | Thursday 8:00 - 9:00 | (no CME credit) |
Organizers: Simon Cherry, Willy Gsell, Bernd Pichler
| S04 | Thursday 8:00 - 10:00 | Moderators: Willy Gsell | (no CME credit) |
8:00
|
Simultaneous PET-MRI for Ultra-High Small-Bore MRIs | |
8:24
|
Design & Performance of Continuous Crystal PET Inserts for Preclinical High-Field PET/MR Imaging | |
8:48
|
Imaging Tumor Heterogeneity | |
9:12
|
Application of PET/MRI for Brain Function | |
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States |
9:36
|
MRI-Based Motion Correction for Retrospective Gating of PET Cardiac Imaging | |
1University of Leuven |
Organizers: Mark Ladd, Rob Tijssen, Cornelis van den Berg
| W03/04 | Thursday 8:00 - 10:00 | (no CME credit) |
8:00
|
Welcome | |
1UMC Utrecht |
8:05
|
MR-Based Treatment Planning | |
1Memorial Sloan-Kettering Cancer Center |
8:20
|
4D- & 5D-Motion-Compensated Reconstruction | |
1Deutsches Krebsforschungszentrum |
8:35
|
fMRI for Therapy Assessment | |
8:50
|
MR-RT System: Real-Time Motion Management | |
1UMC Utrecht |
9:05
|
MR-RT System: Clinical Implementation | |
9:20
|
Future Outlook: MR Methods with High Value for RT | |
1NYU Langone Medical Center, United States |
9:35
|
Panel Discussion |
Organizers: Pia Maly Sundgren, Kei Yamada
| N01 | Thursday 8:00 - 10:00 | Moderators: Pek-Lan Khong & Danielle van Westen |
8:00
|
The Glymphatic & Cerebral Small Vessel Disease | |
1Leiden University Medical Center, Netherlands |
8:30
|
Vasculitis & Neuroinflammation in HIV | |
1UCL, Institute of Neurology, United Kingdom |
9:00
|
Human Glymphatics Assessed with Intrathecal Gd | |
1Radiology, Oslo University Hospital, Norway |
||
Glymphatic MRI (gMRI), utilizing intrathecal Gd as CSF tracer, may demonstrate the capacity for brain clearance of toxic interstitial waste products, such as amyloid-β and tau, which are aggregated in Alzheimer`s disease. There seem to exist important differences between human subjects and previous observations in animal studies. Both glymphatic and brain lymphatic clearance is much slower in man. In iNPH dementia, glymphatic clearance was demonstrated to be reduced. |
9:30
|
Diffusion Images for Assessing Glymphatic System | |
1Nagoya University, Japan |
||
Recently introduced “glymphatic system” is a coined word that combines “gl” for glia and “lymphatic” system. In this hypothesis, the perivascular space functions as a conduit for flowing cerebrospinal fluid into brain parenchyma. Activity of the glymphatic system may be evaluated with diffusion images. Lower diffusivity along the perivascular space seems to reflect impairment of the glymphatic system. Diffusion method may be feasible for evaluating the activity of the glymphatic system. |
10:00
|
Adjournment & Meet the Teachers |
| Power Pitch Theater A - Exhibition Hall | Thursday 8:00 - 9:00 | Moderators: Yukio Miki & Yae Won Park | (no CME credit) |
| 973 | 8:00
|
Data-driven modelling of diffusion MRI changes in Amyotrophic Lateral Sclerosis (ALS) indicates evolution of distal prior to proximal corticospinal tract pathology |
1Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom, 2Department of Psychology, Social Work and Counselling, University of Greenwich, London, United Kingdom, 3Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom, 4Centre for Medical Image Computing, University College London, London, United Kingdom, 5Trafford Centre for Biomedical Research, Brighton and Sussex Medical School, Brighton, United Kingdom |
| 974 | 8:00
|
Progressive Cortical Thinning in Specific Motor Regions in Different Clinical Stages of Patients with Amyotrophic Lateral Sclerosis |
1Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China |
| 975 | 8:00
|
Increased brain entropy in supplementary motor area and precuneus in amyotrophic lateral sclerosis |
1Huashan Hospital, Fudan University, Shanghai, China |
| 976
|
8:00
|
Impaired oxygen metabolism in the brain during visual stimulation in premanifest Huntington's Disease patients detected by 3D-TRIP MRI at 7T |
1Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 6Department of Neuroscience and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD, United States |
| 977 | 8:00
|
The Impact of Leukoencephalopathy on the White Matter Tracts of Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia Treated with Chemotherapy Only |
1Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, United States, 2Epidemiology & Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, United States, 3Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, CA, United States, 4Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, United States, 5Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States |
| 978
|
8:00
|
CO2-challenge measured with dual echo arterial spin labeling as a whole brain biomarker to assess the effect of amyloid deposition in HCHWA-D on the cerebrovascular reactivity. |
1C.J. Gorter Center, Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Leiden Institute of Brain and Cognition (LIBC), Leiden, Netherlands, 3Neurology, Leiden University Medical Center, Leiden, Netherlands, 4Radiology, Leiden University Medical Center, Leiden, Netherlands |
| 979 | 8:00
|
Connectomics Correlates of Neurocognitive Deficits in Gulf War Illness Patients: A Resting State fMRI Study |
1Department of Radiology, Emory University, Atlanta, GA, United States, 2University of Houston Clear-Lake, Houston, TX, United States, 3VA RR&D Center of Excellence, Atlanta VAMC, Decatur, GA, United States, 4Department of Neurology, Emory University, Atlanta, GA, United States, 5Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States |
| 980 | 8:00
|
Interaction of vascular and glymphatic systems in brain waste clearance after diabetes |
1Neurology, Henry Ford Health System, Detroit, MI, United States, 2Physics, Oakland University, Rochester, MI, United States, 3Neurology, Wayne State University, Detroit, MI, United States, 4Radiology, Wayne State University, Detroit, MI, United States |
| 981 | 8:00
|
Detection of Medication-Induced Changes in Thalamic GABA in Patients with Parkinson’s Disease Using J-Edited Spectroscopy |
1Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 2Biostatistics, Vanderbilt University, Nashville, TN, United States, 3Radiology, Vanderbilt University Medical Center, Nashville, TN, United States |
| 982 | 8:00
|
Environmental Paraquat and HFE genetics as factors in the development of Parkinson’s disease |
1Neurosurgery, The Pennsylvania State University - College of Medicine, Hershey, PA, United States, 2Radiology, The Pennsylvania State University - College of Medicine, Hershey, PA, United States |
| 983 | 8:00
|
Magnetic resonance spectroscopic imaging based biomarkers of Parkinson’s disease with mild cognitive impairment registered to MNI152 brain atlas after chemical shift correction |
1Biomedical Engineering Institute, Bogazici University, Istanbul, Turkey, 2Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, 3Psychology and Cognition Research Institute, Bremen University, Bremen, Germany, 4Department of Neurology, Istanbul University, Istanbul, Turkey, 5Department of Physiology, Istanbul University, Istanbul, Turkey |
| 984 | 8:00
|
Disrupted Grey Matter Network Morphology in Parkinson's Disease |
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom, 3Department of Neurology, West China Hospital of Sichuan University, Chengdu, China |
| 985 | 8:00
|
Altered brain network structure during urethane-induced sleep states in a rat model of early-stage Parkinson’s disease |
1A.I.Virtanen Institute, University of Eastern Finland, Kuopio, Finland, 2School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 3Moscow Institute of Physics and Technology, Moscow, Russian Federation, 4Institute of Theoretical and Experimental Biophysics, Pushchino, Russian Federation |
| 986 | 8:00
|
Effect of motor planning and dopaminergic medication on cerebellar network connectivity during dual motor tasking in Parkinson's disease |
1HMCS, NINDS - NIH, Bethesda, MD, United States, 2Neurologie, CHUV, Lausanne, Switzerland, 3Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom, 4ICM-CRICM, UPMC/INSERM, UMR_975, CNRS 7225, Paris, France |
| 987 | 8:00
|
Multimodal quantitative MRI biomarkers: identification of the specific damage in Progressive Supranuclear Palsy versus Parkinson’s disease |
1Centre de NeuroImagerie de Recherche – CENIR, ICM, Paris, France, 2Neuroradiology department, APHP, Pitié-Salpêtrière hospital, Paris, France, 3UMR S 1127, CNRS UMR 7225, ICM, UPMC Univ Paris, Paris, France, 4Clinique des mouvements anormaux, Département des Maladies du Système Nerveux, Hôpital Pitié-Salpêtrière, PARIS, France, 5Service des pathologies du Sommeil, Hôpital Pitié-Salpêtrière, APHP, Paris, France, 6NeuroSpin, CEA, Gif-Sur-Yvette, France |
| Power Pitch Theater B - Exhibition Hall | Thursday 8:00 - 9:00 | Moderators: Luca Saba & Ferdia Gallagher | (no CME credit) |
| 988 | 8:00
|
Imaging collateral ventilation in patients with advanced Chronic Obstructive Pulmonary Disease – relative sensitivity of 3He and 129Xe MRI |
1University of Sheffield, Sheffield, United Kingdom |
| 989
|
8:00
|
Quantitative geometric assessment of regional airway collapse in neonates via retrospectively respiratory-gated 1H UTE MRI |
1Center for Pulmonary Imaging Research, Cincinnati Children's Hospital, Cincinnati, OH, United States, 2Physics, Washington University in St. Louis, St. Louis, MO, United States, 3Upper Airway Center, Cincinnati Children's Hospital, Cincinnati, OH, United States, 4Pulmonary Medicine, Cincinnati Children's Hospital, Cincinnati, OH, United States, 5Radiology, Cincinnati Children's Hospital, Cincinnati, OH, United States, 6Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 7Radiology, University of Wisconsin - Madison, Madison, WI, United States, 8Neonatology and Pulmonary Biology, Cincinnati Children's Hospital, Cincinnati, OH, United States |
| 990 | 8:00
|
Hyperpolarized [1-13C]Pyruvate Magnetic Resonance Imaging of Placentae Associated With Intrauterine Growth Restriction |
1Medical Biophysics, Western University, London, ON, Canada, 2Robarts Research Institute, London, ON, Canada, 3Physiology and Pharmacology, Western University, London, ON, Canada, 4GE Healthcare, Toronto, ON, Canada, 5Obstetrics and Gynaecology, Western University, London, ON, Canada, 6Children's Health Research Institute, London, ON, Canada, 7Lawson Research Institute, London, ON, Canada |
| 991 | 8:00
|
Glycogen Synthesis Mapping Using In Vivo Deuterium Metabolic Imaging (DMI) |
1Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 2Department of Psychiatry, Yale University, New Haven, CT, United States, 3Department of Biomedical Engineering, Yale University, New Haven, CT, United States |
| 992 | 8:00
|
High-Resolution Multishot Diffusion-Weighted Body and Breast MRI using Locally Low-rank regularization |
1Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Electrical Engineering, Stanford University, Stanford, CA, United States, 3GE Healthcare, Menlo Park, CA, United States, 4Department of Bioengineering, Stanford University, Stanford, CA, United States |
| 993
|
8:00
|
Prediction of Breast Cancer Molecular Subtypes Using Conventional Feature Extraction and Two Machine Learning Architectures Based on DCE-MRI |
1Department of Radiological Sciences, University of California, Irvine, CA, United States, 2Tzu-Chi General Hospital, Taichung, Taiwan, 3E-Da Hospital and I-Shou University, Kaohsiung, Taiwan, 4Department of Radiology, University of California, San Francisco, CA, United States |
| 994 | 8:00
|
A diffusion MRI based computer-guided assistance approach for the diagnosis of breast lesions with high accuracy and without the need for contrast agents. |
1Radiology, Kyoto prefectural university of medicine, Kyoto, Japan, 2NeuroSpin, Gif-sur-Yvette, France |
| 995 | 8:00
|
Changes in Pancreatic Stiffness in Obese Adults Receiving an Oral Glucose Load, as Measured by Magnetic Resonance Elastography |
1Shengjing Hospital of China Medical University, Shen Yang, China |
| 996
|
8:00
|
L-Carnitine Shows Beneficial Effects on Cardiac Metabolism and Function: A Hyperpolarized MRS and Langendorff Perfusion Study |
1University of Oxford, Oxford, United Kingdom |
| 997
|
8:00
|
MRI Cine-Tagging of Cardiac-Induced Motion: Diagnostic Performance for Noninvasive Staging of Liver Fibrosis |
1Centre de recherche du centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada, 2Leiden University Medical Centre (LUMC), Leiden, Netherlands, 3Department of Radiology, Radio-Oncology and Nuclear Medicine, Université de Montréal, Montreal, QC, Canada, 4Department of Medicine, Division of Gastroenterology, McGill University Health Centre (MUHC), Montreal, QC, Canada, 5Department of Gastroentology and Hepatology, Université de Montréal, Montreal, QC, Canada, 6Department of Pathology, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada, 7Department of Pathology and Cellular Biology, Université de Montréal, Montreal, QC, Canada, 8MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada |
| 998
|
8:00
|
Improved Speed and Image Quality for Imaging of Liver Lesions with Auto-calibrated Wave Encoded Variable Density Single-Shot Fast Spin Echo. |
1Radiology, Stanford University, Stanford, CA, United States, 2Electrical Engineering and Radiology, Stanford University, Stanford, CA, United States, 3Global MR Applications and Workflow, GE Healthcare, Menlo Park, CA, United States |
| 999 | 8:00
|
A Fully Convolutional Neural Network for 3D Volumetric Liver Lesion Segmentation |
1Arterys, San Francisco, CA, United States, 2Radiology, UC San Diego Health, La Jolla, CA, United States |
| 1000 | 8:00
|
High spatial and temporal free breathing T1 contrast enhanced imaging using a novel 4D variable density, elliptical centric radial stack-of-stars sharing approach |
1Philips Healthcare, Best, Netherlands, 2Philips Healthcare, Bangalore, India, 3Technical University Eindhoven, Eindhoven, Netherlands, 4Philips Research Europe, Hamburg, Germany |
| 1001 | 8:00
|
Higher-Resolution Prostate Diffusion MRI with Minimized Echo Time using Eddy Current Nulled Convex Optimized Diffusion Encoding (ENCODE) |
1Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 2Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States |
| 1002 | 8:00
|
Evaluating the Accuracy of Multi-component T2 and Fractions for Luminal Water Imaging of the Prostate using 3D GRASE with Inner Volume Selection |
1Sunnybrook Research Institute, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Division of Urology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada |
Organizers: Edward DiBella, Mary McDougall
| S01 | Thursday 8:00 - 10:00 | Moderators: Li Feng & Shreyas Vasanawala |
8:00
|
Hardware Methods for Handling Motion: Basic Ideas & Current Methods | |
1Dept. of Radiology, Medical Physics, University Medical Centre Freiburg, Freiburg, Germany |
||
Motion during MR image encoding produces inconsistencies in the acquired k-space data, which results in well-known motion artifacts. In clinical settings patient motion during MRI examinations renders a significant fraction of scans non-diagnostic. Recently, due to the increased availability of ultra-high filed imagers of 7T and above capable of sub-millimeter resolution in vivo, it became apparent that even in normal subjects involuntarily motion of about a millimeter may limit significantly the achievable image quality. Motion correction based on additional motion tracking hardware has demonstrated its ability of achieving excellent image quality both in clinical and research settings. |
8:30
|
Software Methods for Handling Motion: Basic Ideas & Current Methods | |
1Cedars-Sinai Medical Center, United States |
| 1003
|
9:00
|
Hybrid motion sensing with a wireless device, self-synchronized to the imaging pulse sequence. |
1Human Biology, University of Cape Town, Cape Town, South Africa, 2Massachusetts General Hospital, Athinoula A. Martinos Center, Boston, MA, United States, 3Radiology, Harvard Medical School, Boston, MA, United States |
||
Here we combine an accelerometer, angular rate sensor, magnetometer, pickup coil and active marker in a (single) small wireless device. The active marker is used to detect radio frequency pulses, enabling synchronisation to the imaging pulse sequence to within 1 μs accuracy. Sinusoidal waveforms inserted into the imaging pulse sequence (lasting 920 μs) are then measured using the onboard pickup coil to allow real-time position and ADC-gradient timing offsets in all 3 axes. Preliminary results suggest that sub-mm accuracy is possible with very low noise (<0.3 mm) in the raw data captured. The new hardware layout has the potential to enable full prospective motion correction from a single small device that fits on the bridge of the subject's nose. |
| 1004 | 9:15
|
Ultrasound-based sensors for physiological motion monitoring |
1Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States |
||
A small ultrasound-based sensor was developed for use in MRI. It is about 3x3x1cm in size, can be fixed to the skin, readily fits under imaging coils, and provides up to 20,000 data points in a 0.2ms period. A switching circuit was developed allowing up to four such sensors to be used at a time. Examples are show where a sensor was attached over a carotid artery, over the heart or below the ribs, providing information about blood influx to the brain, cardiac motion or breathing, respectively. These devices and associated processing may prove especially useful at high field, where ECG detection proves ineffective. |
| 1005 | 9:30
|
3D ultrasound based motion tracking combined with rapid multislice MR-thermometry for MR guided HIFU on mobile organs. |
1IHU-LIRYC, PESSAC, France, 2Univ. Bordeaux, Centre de recherche Cardio-Thoracique de Bordeaux, Bordeaux, France, 3INSERM U1045, Bordeaux, France, 4Image Guided Therapy, Pessac, France, 5Institute of Mathematics of Bordeaux, Bordeaux, France |
||
MRI-guided High Intensity Focused Ultrasound treatment of mobile organs remain challenging in terms of therapy effectiveness (target tracking) and precision of temperature monitoring (motion and related susceptibility artifacts). In this study, we propose to use some elements of the HIFU transducer in reception for a standalone motion correction of the focus position, allowing full flexibility on the MR-Thermometry sequence. The method is validated in vitro on a mobile gel and in vivo in the liver of pig during breathing, with a 10Hz update of the HIFU focus position under rapid and volumetric MR-thermometry. |
| 1006
|
9:45
|
Monitoring the Complete Scattering Matrix of a Parallel Transmit Coil during Image Acquisition for Retrospective Cardiac Gating at 7T MRI |
1University of Oxford Centre for Magnetic Resonance Research, Oxford University, Oxford, United Kingdom |
||
We propose a new monitoring scheme that enables simultaneous measurements of the complete scattering matrix of a pTx coil during image acquisition by modifying the RF-pulse without prolonging the image sequence and without spin distortion. We show that the use of this monitoring schemes and the measured scattering matrix enable a higher SNR in the estimated cardiac scattering signal, than using RF-reflection of the normal imaging pulse as in previous work. Preliminary results in 7T MRI are shown with successfully, retrospectively gated 2D-CINE images using the proposed method. |
10:00
|
Adjournment & Meet the Teachers |
| N02 | Thursday 8:00 - 10:00 | Moderators: Noam Shemesh & Alex Tze Lun Leong |
| 1007
|
8:00
|
Simultaneous fMRI and multispectral fiber-photometry reveals neurovascular coupling during somatosensory, optogenetic, and chemogenetic stimulation of S1 principle neurons |
1Biomedical Research Imaging Center and Department of Neurology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2Neurobiology Laboratory, National Institute of Environmental Health Sciences, NIH, Durham, NC, United States |
||
In this study, we establish an experimental platform to simultaneously measure: a) genetically encoded calcium indicators (GCaMP) expressing on the excitatory neurons using fiber-photometry, b) cerebral blood volume (CBV) using fiber-photometry, and c) CBV using fMRI. By this platform, we assess neurovascular coupling (GCaMP and CBV comparisons) under chemogenetic stimulation of S1 excitatory neurons in a group of freely moving rats, and demonstrate this platform for concurrent GCaMP, photometry-CBV, and fMRI-CBV measurements with chemogenetic manipulation. |
| 1008
|
8:12
|
Fiber optic mediated extracellular glutamate and intracellular calcium recording with simultaneous fMRI |
1Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2University of Tübingen, Tübingen, Germany |
||
Genetically encoded fluorescent reporter iGluSnFR for extracellular glutamate (Glu) sensing and genetically encoded calcium indicator GCaMP6f for calcium sensing are applied with two channel fiber optic recording system in combination with BOLD fMRI. The intracellular calcium signal from both neurons and astrocytes, as well as the extracellular glutamate signal, were recorded with concurrent BOLD fMRI signal from both hemispheres of anesthetized rats, showing unique temporal dynamic pattern. This multi-modal fMRI platform allows us to specify the neurovascular signaling through the neuro-glial-vascular network and provide better understanding on the cellular and molecular interaction underlying the BOLD fMRI signal. |
| 1009
|
8:24
|
Does ventral hippocampus influence auditory processing? An optogenetic fMRI study |
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China |
||
Hippocampus has traditionally been associated |
| 1010 | 8:36
|
DREADD-fMRI combination detects effects of activation of the striatal D1 receptor-expressing neurons on the basal ganglia-thalamocortical network in mice |
1Institut du Fer à Moulin, Inserm UPMC UMR-S839, Paris, France, 2NeuroSpin, Commissariat à l’Energie Atomique-Saclay Center, Gif-sur-Yvette, France |
||
The dorsal striatum is a key region in motor behavior and motor disorders such as Parkinson’s and Huntington's diseases. We expressed designer receptors exclusively activated by designer drugs (DREADD) in D1 dopamine receptor-expressing neurons in the dorsal striatum in mice and investigated the behavioral and BOLD signal changes during the neuronal activation by clozapine-N-oxide (CNO) treatment. The increased BOLD signals with no susceptibility artifact in the dorsal striatum and the correlated BOLD signal changes in several regions including the substantia nigra and the globus pallidus were observed after CNO injection. |
| 1011
|
8:48
|
A novel method for mesoscale connectome mapping: focal infrared neural stimulation in high-field functional MRI |
1Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China, 2MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China |
||
Establishing connection patterns between cortical columns is essential for understanding human brain networks. However, currently, there is no method to systematically map at this sub-millimeter scale. Here, we combined pulsed infrared neural stimulation (INS) with high field fMRI. Applying this method in cat and monkey brains, we found that single site INS stimulation produces reproducible, intensity-dependent activation. Our experiments revealed (1) connections between cortex and subcortical locations, (2) long-range cortico-cortical connections, and (3) local cortical connections. We suggest that INS-fMRI is a new in vivo functional tract tracing technique that can map networks with high spatial resolution. |
| 1012
|
9:00
|
Vagus Nerve Stimulation Evokes Widespread BOLD Responses in the Rat Brain |
1Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 2Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States, 3Psychological Science, Purdue University, West Lafayette, IN, United States |
||
Vagus nerve stimulation (VNS) is an emerging treatment for brain disorders, such as depression and epilepsy. However, its efficacy varies, and its mechanism is unclear. Prior studies have used functional MRI (fMRI) to map brain activations with VNS in human brains but yielded inconsistent findings. The source of the inconsistency might be attributed to the complex temporal characteristics of VNS-evoked responses that cannot be fully explained by simplified response models. Using a rat model, we aimed to characterize the VNS evoked responses at the level of brain networks without assuming any priori response model. Our results suggest that the repetitive and block-wise stimulation to the vagus nerve induces activations at widespread brain regions. The responses are complex and variable across regions, much beyond what can be described with conventionally assumed HRF. |
| 1013 | 9:12
|
Focused Ultrasound Induced Opening of the Blood-Brain Barrier Disrupts Inter-Hemispheric Resting State Functional Connectivity in the Rat Brain |
1Brigham and Women's Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Boston Children's Hospital, Boston, MA, United States |
||
Focused ultrasound can be used as a non-invasive method to disrupt the blood-brain barrier in a targeted, localized, and safe manner. This technology allows for targeted delivery of drugs into the brain for treatment and research applications. While FUS-induced BBB opening has been shown to be safe, there is evidence that it modulates neuronal activity and/or vascular hemodynamics. This study uses resting state fMRI data from rats to investigate these effects. We find that FUS BBB opening targeted to the primary somatosensory cortex reduces local functional connectivity in the ipsilateral sensorimotor cortical areas and in the contralateral primary somatosensory cortex. |
| 1014 | 9:24
|
Development of Multimodal Neuroimaging Technology at Ultrahigh Field for Studying Brain Function from Cell to Network |
1Center of Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, United States, 2School of Electrical and Computer Engineering, Department of Biological Sciences, Purdue University, West Lafayette, IN, United States |
||
Functional MRI based on blood oxygenation level dependent (BOLD) contrast has become an indispensable method for mapping effective and functional connectivity. However, subject to intrinsic resolution limit, fMRI cannot be used to directly explore cellular and neurovascular mechanisms underlying BOLD contrast at microscopic scale. To overcome this obstacle, a novel integrated two-photon fluorescence microscopy (TPM)-MRI system at ultrahigh field of 16.4 tesla is proposed and developed. This multimodal neuroimaging tool will enable noninvasive and simultaneous measurement of neurophysiological change and fMRI signal with unprecedented resolution and sensitivity, thus, bridging microscopic neural and vascular dynamics with macroscopic brain networks. |
| 1015 | 9:36
|
Dopamine Release and Neural Activation Differs between Control and MDD during Reward Anticipation: a Simultaneous [11C]Raclopride PET-fMRI Study |
1Radiological Sciences Laboratory, Department of Radiology, Stanford University, Palo Alto, CA, United States, 2Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, 3Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, 4A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 5Center for Social and Affective Neuroscience, Linköping University, Linköping, Sweden, 6Department of Psychology, Stanford University, Palo Alto, CA, United States, 7Applied Science Lab, GE Healthcare, Menlo Park, CA, United States |
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The interaction between the midbrain dopaminergic system and the striatum is implicated in reward processing; it is still unknown, however, how this interaction is altered in Major Depressive Disorder (MDD). In the current study, we compared coupling of dopamine release/binding and neural activity in adults diagnosed with MDD and healthy controls (CTLs) during a monetary incentive delay (MID) task using simultaneous $$$[^{11}C]$$$Raclopride PET and fMRI. We obtained significant correlations in CTLs but not in MDD patients, indicating that the decoupling of dopaminergic system and striatum, especially nucleus accumbens, may play a vital role in the pathophysiology of MDD. |
| 1016 | 9:48
|
Validating the detection of slow BOLD changes with multi-echo fMRI denoised data using simultaneous EEG |
1ETPB/NIMH, NIH, Bethesda, MD, United States, 2NINDS, NIH, Bethesda, MD, United States, 3NIMH, NIH, Bethesda, MD, United States, 4NIH, NIH, Bethesda, MD, United States, 5Mount Sinai, New York, NY, United States |
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In this study we use simultaneous electroencephalography (EEG) and multi-echo functional magnetic resonance imaging (ME-fMRI) to demonstrate the ability of ME-ICA denoising to resolve slow changes without need for baseline models. We use a visual flickering checkerboard with varying contrast to elicit a response measurable by fMRI and also EEG. We find that the ME-denoised data improves the fMRI timeseries correlation with the ideal task without removing the task signature that is shown to exist in the EEG data. |
| N03 | Thursday 8:00 - 10:00 | Moderators: Valentina Taviani & Jakob Assländer |
| 1017
|
8:00
|
Fast 3D MR fingerprinting with spiral projection acquisition for whole brain quantification imaging |
1Center for Brain Imaging Science,Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, 2State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China |
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A spiral projection acquisition scheme was used for 3D MR fingerprinting to achieve isotropic resolution of 1.2x1.2x1.2 mm3 with FOV of 240x240x240 mm3 for whole brain T1 and T2 mapping within 4.3 minutes. |
| 1018
|
8:12
|
Magnetic Field Fingerprinting (MFF) |
1Siemens Healthcare GmbH, Erlangen, Germany, 2Max Schaldach-Stiftungsprofessur für Biomedizinische Technik, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 3Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 4Georg-August-Universität Göttingen, Göttingen, Germany, 5Radiology, Case Western Reserve University, Cleveland, OH, United States |
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Parameter maps obtained from Magnetic Resonance Fingerprinting (MRF) are sensitive to magnetic field inhomogeneities. Most MRF publications are based on FISP to minimize the dependency on B0. In FISP however, the magnetization is spoiled at the end of every TR resulting in lower T2 differentiation capability and SNR compared to TrueFISP. We propose an MRF variant that applies TrueFISP, FISP and FLASH in a continuous acquisition, and additionally incorporates B1 and B0 in the dictionary, which are resolved by a pattern match. This implementation enables increased spiral resolution and spiral deblurring with the derived high-resolution B0 maps. |
| 1019
|
8:24
|
Improving uniqueness of Magnetic Resonance Fingerprinting (MRF) signal evolutions using spatio-temporal variation of non-linear ΔB0 shim coil. |
1Radiology, Case western reserve university, Cleveland, OH, United States, 2Quality Electrodynamics, Mayfield Village, OH, United States |
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Magnetic Resonance Fingerprinting (MRF) framework uses variation in acquisition parameters to generate unique signal evolutions, which can be treated as “fingerprints”. The iPRES coil concept provides independent and dynamic variations of multiple magnetic fields, which can be used to improve the uniqueness of signal evolutions through spatio-temporal variations of multiple fields. In this study, we present a proof-of-concept implementation illustrating spatio-temporal variations of local non-linear ΔB0 fields improve the uniqueness of signal evolutions for MRF. Our phantom results show reduction in variation of estimated tissue properties for data with 500frames, thereby illustrating the capability of acceleration using these field variations. |
| 1020
|
8:36
|
Optimized 3D Stack-of-Spirals MR Fingerprinting with Hybrid Sliding-Window and GRAPPA Reconstruction |
1Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, 2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States |
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We demonstrate 3D stack-of-spiral MRF acquisition with hybrid sliding-window and GRAPPA (SW+GRAPPA) reconstruction using a constant density spiral (CDS) rather than standard variable density spiral (VDS). The CDS was found to mitigates high-frequency artifacts after in-plane sliding-window (SW) combination and improve the subsequent GRAPPA and dictionary matching reconstruction. The proposed 3D constant density stack-of-spiral MRF allows whole-brain (240×240×192 mm3) parametric mapping at 1 mm isotropic resolution with high quality in 8 minutes. |
| 1021
|
8:48
|
Diffusion-weighted in vivo imaging with ≤100 µm resolution: Principles and applications to ADC mapping of pregnant mice |
1Departments of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, 2Department of Electrical Engineering and Computer Science, UC Berkeley, Berkeley, CA, United States |
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Although a major advantage of SPatiotemporal ENcoding (SPEN) vs EPI is a higher immunity to artifacts, it suffers –as all single-shot experiments– from resolution and SNR limitations. These can be dealt by multi-scan interleaving, which unlike EPI counterparts leads to independent low-resolution images free from aliasing artifacts. We present an acquisition and processing protocol that reconstructs from these data a composite image free from hardware or motional imperfections, possessing unprecedented resolution. The power of this self-referenced method is demonstrated with in vivo ADC maps of brains, kidneys and fetal organs in pregnant mice, possessing resolutions in the 78-230 µm range. |
| 1022 | 9:00
|
Segmentation of Brain Tissues using a Bayesian Estimation of Multicomponent Relaxation Values in Magnetic Resonance Fingerprinting |
1Radiology, Case Western Reserve University, Cleveland, OH, United States, 2Radiology, University Hospitals, Cleveland, OH, United States |
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A Bayesian methodology has been previously applied to MRF reconstructions to analyze subvoxel T1 and T2 distributions. The multidimensional results from this algorithm are difficult to visualize. We propose to apply this Bayesian approach in the brain to create T1 and T2 Gaussian distributions to represent various tissue types. Using these distributions as prior information, the Bayesian methodology is applied over the brain with a smaller dictionary. Results from this Bayesian approach with a smaller dictionary are weighted by the Gaussian probabilities and summed to create tissue probability maps in normal volunteers and a brain tumor patient. |
| 1023
|
9:12
|
Simultaneous quantification of T1, T2 and Apparent Diffusion Coefficient using Magnetic Resonance Fingerprinting based on Echo Planar Imaging |
1Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany, 2Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States, 3Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 4Heidelberg University, Mannheim, Germany |
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In this study we propose to integrate diffusion imaging into magnetic resonance fingerprinting, a method that has shown promise for time-efficient simultaneous quantification of multiple tissue parameters. The proposed sequence for quantitative T1, T2 and the apparent diffusion coefficient (ADC) is based on using Cartesian EPI readout. The contrast is generated using spin-echo EPI and gradient spoiling with diffusion gradients of varying moment and varying TR and TE. Joint T1, T2 and ADC parameter-maps acquired in phantoms are in good agreement with reference measurements and demonstrate high quality in-vivo maps, within a scan time of 28 seconds per slice. |
| 1024
|
9:24
|
Accelerated Distortion-Free Diffusion Imaging at 7T – by Fusing PSF and VAT |
1Department of Biomedical Magnetic Resonance, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany, 2Department of Radiology, Mayo Clinic, Rochester, MN, United States, 3Siemens Healthcare, San Francisco, CA, United States, 4Site Magdeburg, German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany, 5Leibniz Institute for Neurobiology, Magdeburg, Germany, 6Center for Behavioral Brain Sciences, Magdeburg, Germany |
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In this study, combining view angle tilting (VAT) with the novel PSF diffusion EPI sequence demonstrates the feasibility to further accelerate distortion-free diffusion weighted imaging at high field. |
| 1025
|
9:36
|
Musculoskeletal MR Fingerprinting with dictionary-based fat and water separation |
1Department of Physics, University of Pisa, Pisa, Italy, 2IMAGO7 Foundation, Pisa, Italy, 3Laboratory of Medical Physics and Magnetic Resonance, IRCCS Fondazione Stella Maris, Pisa, Italy, 4Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 5GE Healthcare, Munich, Germany |
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The purpose of this work is to obtain quantitative MRI maps of fat and water with a fast acquisition using MR Fingerprinting (MRF). The major advantage of MRF is its intrinsic multicomponent quantification capability, which overcomes the limitations of traditional separation techniques. Previous methods using MRF have repeated the same acquisitions for multiple echo times in order to obtain fat fraction maps. Here, variable echo times within a single MRF acquisition are used, in order to estimate T1 and PD of water and fat. We demonstrate quantitative maps in 16s per slice and improved delineation of anatomy in human knees. |
| 1026 | 9:48
|
Quantitative Ultrashort Echo Time (UTE) Magnetic Resonance Imaging of Knee Osteoarthritis (OA) |
1University of California, San Diego, San Diego, CA, United States, 2VA San Diego Healthcare System, San Diego, CA, United States |
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In this study we aimed to develop a comprehensive quantitative UTE imaging package including UTE-Cones actual flip angle imaging (UTE-Cones-AFI) for accurate B1 mapping, UTE-Cones variable flip angle (UTE-Cones-VFA) for T1 mapping, 3D UTE-Cones-MT for MT modeling, UTE-Cones-AdiabT1rho for T1r mapping, and multi-echo UTE-Cones for T2* mapping. The techniques were evaluated on cadaveric human knee joints. |
| N04 | Thursday 8:00 - 10:00 | Moderators: Koji Kamagata & Timothy Shepherd |
| 1027 | 8:00
|
Development of a diffusion-weighted SSFP acquisition and processing pipeline to quantify the diffusion properties of the post-mortem ALS brain at 7T |
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Department of Radiology, University of Chicago, Chicago, IL, United States, 3Clinical Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 4Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom |
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An acquisition and processing pipeline is outlined to quantify the diffusion properties of post-mortem brain samples from diffusion-weighted steady-state free precession (dwSSFP), as part of an ongoing project examining the impact of amyotrophic lateral sclerosis (ALS) on the human brain. Preliminary results are presented comparing the post-mortem diffusion properties of control brains and patients diagnosed with ALS over the corpus callosum. Clear trends are observed within the results, with a maximum deviation between control and ALS brains observed within callosal regions connecting the motor cortices in the two hemispheres. |
| 1028 | 8:12
|
Optimization of advanced high-resolution diffusion-weighted imaging (DWI) techniques in lower neck imaging |
1PUMCH, Beijing, China, 2Siemens, Beijing, China, 3Siemens, Shenzhen, China |
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Readout-segmented echo-planar imaging (rs-EPI) could significantly reduce magnetic susceptibility artifacts in head and neck regions. In this study, the images were qualitatively evaluated among three types of rs-EPI: with and without readout partial Fourier (RPF), and with simultaneous multi-slice (SMS) technique. The SNRs and CNRs were compared with the additional use of special surface coils (SC). There was no significant differences in the image quality, SNRs, or CNRs among three rs-EPI acquisition methods of all the 31 volunteers and 9 hypopharyngeal carcinoma patients. Markedly, the special surface coils offered better image quality for the evaluation of lower neck lesions. |
| 1029
|
8:24
|
Gaze Evoked Changes in Diffusion Characteristics of Human Optic Nerve |
1Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, 2Radiology, Stony Brook University Hospital, Stony Brook, NY, United States, 3Ophthalmology, Stony Brook University Hospital, Stony Brook, NY, United States |
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Disorders of the optic nerve (ON) are both life and sight threatening. Although disorders such as papilledema and ischemic optic neuropathy cause deformation of the peripapillary basement membrane layer, earlier pathological changes to the ON may occur further away from the eye. In this study a novel zoom-RESOLVE DTI method was developed for in vivo human ON imaging. Significant changes were observed in diffusion characteristics when comparing adduction, primary position and abduction. Gaze evoked changes in diffusion characteristics have the potential to assess diseases that affect the optic nerve before manifestation of ocular anatomical changes observed in OCT. |
| 1030 | 8:36
|
The connectivity fingerprint of the fusiform gyrus predicts the Autism Observation Scale for Infants (AOSI) in Tuberous Sclerosis Complex |
1Radiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, 2Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, 3Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States |
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Autism spectrum disorder is characterized by severe deficits in face processing. We achieved MR diffusion imaging of 27 infants (~2yo) with Tuberous Sclerosis Complex, a population at risk of autism, and assessed whether the structural connectivity fingerprint of their fusiform gyrus, a central region in face perception, can predict the Autism Observation Scale for Infants total score. We found that the diffusion tensor imaging connectivity fingerprint had poor prediction capabilities. In contrast, a diffusion compartment imaging, fixel-based fingerprint captured the structure of the abnormal connectivity in infants at risk of ASD and allowed in-sample prediction with a correlation of 0.97. |
| 1031 | 8:48
|
U-fiber, Long-range, and Inter-limbic Tractography Comparison in Epilepsy Patients at 7 Tesla |
1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States |
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This study measures alterations in wholebrain connectivity and connectivity of the suspected seizure onset zone (SOZ) in MRI-negative epilepsy patients. Short-range (U-fibers), long-range, and inter-limbic white matter tracts were measured independently in a group of 19 epilepsy subjects and 10 healthy controls using diffusion imaging. Relative wholebrain hypo-connectivity of both U-fibers and inter-limbic fibers was found in epilepsy subjects. Additionally, hyper-connectivity of all 3 fiber types was found in SOZ regions compared with non-SOZ regions. These findings suggest abnormal connectivity in MRI-negative patients may prove useful in SOZ localization and treatment planning. |
| 1032 | 9:00
|
Diffusion-based tractography atlas of the human acoustic radiation |
1CIMeC Center for Mind/Brain Sciences, Trento, Italy, 2Structural and Functional Connectivity Lab, Div. of Neurosurgery, “S.Chiara Hospital", Trento, Italy |
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This study presents the first tractography-based atlas of the acoustic radiation from a population of 34 young healthy subjects. The atlas was constructed using high quality MRI data from the Human Connectome Project. The acoustic radiation reconstruction was optimized with a systematic evaluation of MRI acquisition and analysis parameters using as reference reconstructions validated from an ex-vivo dissection study from our group (Maffei et al., 2017). The optimized reconstruction parameters and the atlas may be used in future studies interested in identifying and characterizing the acoustic radiation. |
| 1033 | 9:12
|
OGSE- versus PGSE-derived ADC measurements in patients with liver metastases show reduced hindrance to diffusion at short length scales |
1CR-UK Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden Hospital, London, United Kingdom, 2Siemens Healthcare, Erlangen, Germany |
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The oscillating gradient spin echo (OGSE) diffusion method probes the diffusion spectrum at defined length scales. This comparative study investigates the effect of short diffusion times on apparent diffusion coefficient (ADC) measurements using OGSE and PGSE diffusion sequences in six patients with liver metastases. Similar cohort mean ADC values were reported for all PGSE measurements, while the OGSE-derived ADC was significantly higher (paired t-test p-value=0.029). This increase in OGSE-measured ADC in liver tumours suggests that water molecules suffer less hindrance at shorter diffusion times (as already observed in brain studies) and provides additional information regarding the tissue microstructure. |
| 1034 | 9:24
|
Prostate microstructure specificity with diffusion relaxometry |
1Radiology, NYU School of Medicine, New York, NY, United States, 2Sackler Institute of Graduate Biomedical Sciences, NYU School of Medicine, New York, NY, United States |
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We identify the contributions of prostate cellular and glandular compartments to the overall diffusion time-dependent diffusion tensor, by varying echo time and relying on their different T2 values. We test the functional form of compartment tensor eigenvalues with respect to the diffusion time against a variety of tissue models, and find the glandular tissue being best described by the short-time surface-to-volume limit, whereas the random permeable barrier model is most applicable in cellular tissue, and for tumors of various grade. Our framework allows quantification of glandular sizes, cellular fiber diameters, membrane permeability, compartment T2-values, and volume fractions. |
| 1035 | 9:36
|
High resolution diffusion MRI maps of mice with normal and dysfunctional placentas reveal clear fetal differences |
1Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, 2Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel |
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DWI could evaluate pregnancy-related dysfunctions, yet EPI’s sensitivity to motions and air/water/fat heterogeneities prevent these studies in preclinical settings. We developed DWI methodologies based on SPatiotemporal ENcoding (SPEN) for overcoming these obstacles, delivering ADC images at ≈150µm resolutions. We demonstrate the power of these new methods to resolve placental layers (maternal, fetal, trophoblastic) and umbilical cords, as well as brain features in developing mice fetuses. Daily monitoring of pregnancies for naïve and for eNOS-/- mice also showed differences in the development of placental and fetal (e.g. brain) structures. SPEN DWI thus opens the potential for the early detection of pregnancy disorders. |
| 1036 | 9:48
|
A Pilot Study of Correlations Between Mean Diffusivity and Drug Release Over Time For an Implantable Drug Delivery System |
1Basic Medical Sciences, Purdue University, West Lafayette, IN, United States, 2Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 3Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States |
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In situ forming implants (ISFI) allow for precise placement of a drug eluting depot into the body, using a simple injection. However, the properties of the injection sites can alter the drug release profile in situ. Diffusion weighted imaging (DWI) provides a method for non-invasively and nondestructively tracking changes in the implant diffusivity in situ. Using DWI, we have characterized the diffusivity profile of ISFIs made using a poly(lactic-co-glycolic) acid polymer, loaded with the mock drug fluorescein. The ability to characterize the diffusivity profile of implants in situ, will provide the necessary tools for improving the rational design of implants. |
| S02 | Thursday 8:00 - 10:00 | Moderators: James MacKay & Erin Englund |
| 1037 | 8:00
|
Fully Automated Deep Learning Pipeline for Meniscus Segmentation and Lesion Detection |
1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States |
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Damage to the meniscus is a physically limiting injury that can lead to further medical complications. Automatically classifying this type of meniscal damage poses the advantage for quicker and more accurate diagnosis at the time of an MRI scan. Using a fully automated deep learning pipeline we identify the region around the 4 meniscal horns and then classify if a lesion exists and if so, its severity based on WORMS grading. Lesion detection achieved 89.81% specificity and 81.98% sensitivity. This algorithm has the ability to quickly identify meniscal lesions from MRI and filter higher risk lesion subjects. |
| 1038 | 8:12
|
The influence of different MR contrasts in multi-channel convolutional neural networks on pseudo-CT generation for orthopedic purposes |
1UMC Utrecht, Utrecht, Netherlands |
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Conventional MR images and pseudo-CT’s (pCT’s) generated using state-of-the-art machine learning techniques poorly characterize bone anatomies, preventing applicability for orthopedic applications. We hypothesize that smart use of several specific MR contrasts will expose the information needed for diagnostic quality bone visualization. We designed a patch-based convolutional neural network taking groups of different MR contrasts -which were obtained from a single multi-gradient sequence- as inputs . It generated competitive pCT scans, capturing local anatomical variances present in the dataset. We show that Dixon reconstructed inputs appear to generate better soft-tissue visualization, while complex-valued data show promising results in bone reconstruction. |
| 1039
|
8:24
|
Super-Resolution Musculoskeletal MRI using Deep Learning |
1Radiology, Stanford University, Palo Alto, CA, United States, 2Bioengineering, Stanford University, Palo Alto, CA, United States, 3LVIS Corporation, Palo Alto, CA, United States, 4Orthopaedic Surgery, Stanford University, Palo Alto, CA, United States, 5Neurology & Neurological Sciences, Stanford University, Palo Alto, CA, United States, 6Electrical Engineering, Stanford University, Palo Alto, CA, United States, 7Neurosurgery, Stanford University, Palo Alto, CA, United States |
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Near-isotropic high-resolution magnetic resonance imaging (MRI) of the knee is beneficial for reducing partial volume effects and allowing multi-planar image analysis. However, previous methods exploring isotropic resolutions, typically compromised in-plane resolution for thin slices, due to intrinsic signal-to-noise ratio (SNR) limitations. Even computer-vision-based super-resolution methods have been rarely been used in medical imaging due to limited resolution improvements. In this study, we utilize deep-learning-based 3D super-resolution for rapidly generating high-resolution thin-slice knee MRI from slices originally 2-8 times thicker. Through quantitative image quality metrics and a reader study, we demonstrate superior performance to both conventionally utilized and state-of-the-art super-resolution methods. |
| 1040 | 8:36
|
Fully-Automated One-Button-Push 10-min 3D CAIPIRINHA SPACE TSE MRI of the Knee: A Multi-Center Multi-Reader Multi-Field-Strength Validation Study |
1Ospedale Regionale di Lugano, Lugano, Switzerland, 2Siemens Healthcare GmbH, Erlangen, Germany, 3The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Bond Business School, Gold Coast, Australia |
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2D TSE MRI is widely used for the evaluation of internal knee derangement but is time-consuming. Recently introduced 3D TSE acceleration strategies, such as CAIPIRINHA allow for fast sampling, and together with AutoAlign technology enable now fully automated one-button-push 3D MRI protocols in 10 minutes total scan time. In a prospective study of 150 subjects, we analyzed the frequencies of structural abnormalities, inter-reader reliability, inter-method concordance, diagnostic definitiveness, and interchangeability of 10-min 3D CAIPIRINHA SPACE TSE protocols and 20-min 2D TSE standard-of-reference protocols. Our results indicated that that 10-min 3D TSE protocols are at least equivalent to 20-min 2D TSE protocols for the diagnosis of internal derangement of the knee. |
| 1041 | 8:48
|
Reducing scan time for full MRI examination of the ankle by 45% while maintaining diagnostic value using combined compressed sensing and parallel imaging. |
1Radiology & Nuclear medicine, Academic Medical Center, Amsterdam, Netherlands, 2Radiologie, Academic Medical Center, Amsterdam, Netherlands, 3Healthcare, Philips, Best, Netherlands |
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Dixon imaging is a well-known imaging technique that provides robust water-fat separation but requires relatively long acquisition times. We scanned twelve healthy volunteers with a standard ankle examination containing multiple Dixon sequences and an accelerated examination using CS-SENSE, a combination of Parallel Imaging and Compressed Sensing. A five-point Likert scale was used to compare reference images to CS-SENSE images. Although using CS-SENSE caused a slight SNR reduction, the diagnostic value was not impaired. Applying CS-SENSE on an ankle examination protocol resulted in a feasible reduction of the total acquisition time by 45% from 13’38” to 7’49”, without losing diagnostic value. |
| 1042
|
9:00
|
Intravoxel Incoherent Motion (IVIM) Imaging in Human Achilles Tendon |
1Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, 2Radiology, Stony Brook University Hospital, Stony Brook, NY, United States |
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Clinically, Achilles tendon (AT) rupture accounts for 40-60% of all operative tendon repairs. AT microcirculation plays a crucial role in the progression of tendinopathy and tendon repair. In this study a novel ste-RESOLVE IVIM protocol was developed to image AT microcirculation. Healthy participants were imaged pre- and post-exercise, and exercised induced increases in blood volume and blood flow were observed. AT tendinopathy patients exhibited greater baseline blood volume and blood flow when compared to healthy participants. For the first time, a robust MRI-based technique was developed to investigate the role of Achilles tendon microcirculation in tendinopathy. |
| 1043 | 9:12
|
Visualisation and quantification of collagen fibers in a partially torn ligament using magic angle imaging |
1Medicine, Surgery and Cancer, Imperial College London, London, United Kingdom, 2University of Adelaide, Adelaide, Australia, 3Mechanical Engineering, Imperial College London, London, United Kingdom, 4Department of Clinical Sciences and Services, Royal Veterinary College, Hertfordshire, United Kingdom |
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Human partial anterior cruciate ligament tears can be extremely difficult to diagnose with conventional MRI. Variations of signal intensity within the ligament are suggestive of injury but it is not possible to confirm damage or assess the collagen alignment within the ligaments. We have shown that magic angle imaging has the ability to visualise and quantify collagen fibers in a partially torn canine cruciate ligament. Furthermore it can delineate between damaged and healthy fiber bundles within the same ligament. This method has the potential to become a non-invasive alternative to arthroscopy for assessing and monitoring ligament damage and repair outcomes. |
| 1044 | 9:24
|
Longitudinal Changes in Quantitative MRI and Ultrasound Metrics of Patellar Tendon are Associated with Tendon Degeneration and Leg Dominance within of Collegiate Basketball Players over One Season of Play |
1Radiology and Imaging, Hospital for Special Surgery, New York, NY, United States, 2Biostatistics, Hospital for Special Surgery, New York, NY, United States |
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This study assessed correlations between quantitative T2* and Shear wave elastography (SWE) ultrasound metrics of the patellar tendon and qualitative morphologic grades patellar tendinosis (PT) within collegiate basketball players over one season of play. Within the current study, significant and strong correlations existed between T2* and SWE metrics, though morphologic PT grades were correlated with T2* metrics only. These findings support the notion that T2* relaxometry could benefit the clinical management of PT, as it is sensitive to changes in pathologic severity over time, and could therefore serve as a metric to guide treatment plans and evaluate intervention efficacy. |
| 1045
|
9:36
|
Isotropic resolution DTI of lower back nerves using a phase-corrected diffusion-prepared 3D TSE |
1Interventional and Diagnostic Radiology, Technical University of Munich, Munich, Germany, 2Institute of Medical Engineering, Technical University of Munich, Garching, Germany, 3Philips Healthcare, Hamburg, Germany, 4Interventional and Diagnostic Neuroradiology, Technical University of Munich, Munich, Germany |
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Diffusion-prepared 3D TSE (dprep-3D TSE) has been applied for isotropic-resolution distortion-free proximal- and peripheral-nerve DWI. Dprep-3D TSE has been combined with magnitude stabilizers to reduce magnitude modulation induced by motion and eddy currents and has used velocity compensation to reduce motion-induced phase modulation in diffusion-weighted signals. However, due to the multi-shot nature of dprep-3D TSE, remaining motion-induced phase leads to image and DTI-parameter artifacts and requires phase navigation. The purpose of this work is to develop a phase-navigation and phase-correction scheme for dprep-3D TSE and to apply the developed method in vivo for isotropic-resolution DTI of lumbosacral and sciatic nerves. |
| 1046 | 9:48
|
Simultaneous Multislice Accelerated Diffusion-Tensor Imaging of Thigh Muscles in Myositis |
1Radiology, Peking Union Medical College Hospital, Beijing, China, 2Rheumatology, Peking Union Medical College Hospital, Beijing, China, 3Radiology, Shenzhen Sun Yat-Sen Cardiovascular Hospital, Shenzhen, China, 4MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China |
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We investigated the clinical feasibility of using simultaneous multislice accelerated echo planar imaging diffusion-tensor imaging (SMS-EPI-DTI) to image thigh muscles of both 10 healthy control subjects and 20 dermatomyositis (DM)/ polymyositis (PM) patients. This technique yielded a reduced scan time to only about five minutes. The results showed that the tractographic imaging and DTI-derived parameters of edematous muscles differed among affected and unaffected muscles of the DM/PM patients and normal muscles of the control subjects. In conclusion, SMS-EPI-DTI is clinically feasible for imaging thigh muscles and quantitatively evaluating edematous muscles of DM and PM patients. |
| S03 | Thursday 8:00 - 10:00 | Moderators: Markus Henningsson & Dana Peters |
| 1047 | 8:00
|
Automatic AHA model segmentation of cardiac T1 maps with deep learning |
1Fondazione Toscana "G. Monasterio", Massa, Italy, 2University of Pisa, Pisa, Italy, 3Fondazione Toscana "G. Monasterio", Pisa, Italy |
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We proposed a fully automated approach for the segmental analysis of T1 mapping using a fully convolutional neural network architecture. T1 maps acquired using the MOLLI sequence from 394 subjects were considered. Excellent segmentation results are demonstrated by high Jaccard (0.969±0.023) and a Dice (0.984±0.012) indexes. No significant difference in the obtained segmental T1 values compared to manual measurements was found, with a mismatch percentage ranging from 0.95% to 3.14% across segments. |
| 1048
|
8:12
|
Single Breath-held, ECG-Free Cardiac CINE MRI using Parallel Imaging and Deep Learning Combined Image Reconstruction |
1Radiology, University of California, Los Angeles, Los Angeles, CA, United States, 2Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United States |
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Cardiac CINE MRI is widely used for evaluating ventricular wall motion and cardiac function. Conventional cardiac CINE consists of ECG-triggered k-space segmented 2D acquisitions, each performed within a breath-hold. In this study, we propose an ECG-free, cardiac CINE protocol that covers the entire LV within a single breath-hold. Our solution is based on a highly accelerated real-time imaging that is enabled by our recently proposed parallel imaging and deep learning combined (PI-DL) image reconstruction. In this study, we evaluated the proposed solution in healthy volunteers and compare its performance with cardiac CINE images acquired using conventional protocol. |
| 1049 | 8:24
|
Deep Convolutional Neural Network Enhanced 3D High Resolution Turbo Spin Echo Intracranial Vessel Wall Imaging |
1Philips Research North America, Cambridge, MA, United States, 2Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, 3The Institute of Artificial Intelligence and Robotics, Xi'an Jiaotong University, Xi'an, China, 4Philips Research Hamburg, Hamburg, Germany, 5Vascular Imaging Lab, Department of Radiology, University of Washington, Seattle, WA, United States |
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Turbo spin echo (TSE) imaging with variable flip angle (VFA) is commonly used for three-dimensional (3D) high resolution intracranial vessel wall imaging. However, different tissues may experience various blurring effects particularly for longer TSE factor. In this study, a deep convolutional neural network is trained to provide a solution for this special deblurring problem. Combined with a signal-to-noise ratio (SNR)-priority VFA design scheme, the developed technique can provide a better tradeoff across scan efficiency, point spread function and SNR for 3D TSE acquisitions. Preliminary results have demonstrated its improvement for sharper delineation of intracranial vessel wall and plaque boundaries at isotropic 0.5mm resolution. |
| 1050 | 8:36
|
Super Resolution MRI Using 3D Generative Adversarial Network: Towards Single Breath-Hold Coronary MR Angiography |
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles, CA, United States, 3Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 4Division of Cardiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea |
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Coronary MRA is an attractive imaging tool to offer noninvasive, radiation-free evaluation of coronary artery disease. However, long scan time and sensitivity to motion limit its current clinical applications. In this paper, we propose a |
| 1051 | 8:48
|
Automatic Segmentation of Carotid Vessel Wall in Multi-Contrast Blackblood Images using Deep Learning |
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2Vascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle, WA, United States |
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In this work, we proposed an automatic approach for segmentation of carotid vessel wall in multi-contrast blackblood images, using a fine-tuning U-net neural network. The U-net network consists of an encoder path that captures context and reduces data dimension and a symmetric decoder path that enables precise localization and high resolution. The fine-tuning was utilized to accommodate multi-contrast images input. The pixel-level sensitivity, specificity and IoU of our model achieved 0.869, 0.987 and 0.751 on the test data set, respectively. |
| 1052
|
9:00
|
Fetal whole-heart 3D cine reconstruction using motion-corrected multi-slice dynamic imaging |
1School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, 2Department of Congenital Heart Disease, Evelina London Children's Hospital, London, United Kingdom, 3Centre for the Developing Brain, King's College London, London, United Kingdom |
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Cine fetal cardiac imaging with whole heart coverage presents numerous challenges due to maternal and fetal motion as well as high heart rate and lack of reliable independent synchronisation signal. To overcome these challenges, highly accelerated multi-slice 2D dynamic images were retrospectively reordered in time and aligned in space to produce a 3D cine using scattered interpolation methods with outlier rejection. The proposed methods were tested on ten human fetal subjects and validated using a numerical phantom. |
| 1053 | 9:12
|
Dark-blood T2 mapping for improved assessment of the left ventricular subendocardium, right ventricle and left atrium |
1Yale University, New Haven, CT, United States |
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The accuracy of cardiac T2 mapping in small structures, such as the subendocardium, right ventricle, and left atrium, is impaired by the partial-voluming effect between myocardium and blood. In this work, we propose a dark-blood T2 mapping method that nulls the blood prior to the T2 quantification, so that partial-voluming is reduced and T2 estimation accuracy in these small structures is improved. Both conventional and the proposed dark-blood T2 mapping methods were performed in healthy subjects. The results demonstrated the potential of dark-blood T2 mapping to improve the clinical assessment of the subendocardium, right ventricle, and left atrium. |
| 1054 | 9:24
|
Myocardial Infarct Border Zone Metabolism Measured by Hyperpolarized 13C-Pyruvate MRI |
1University of Pennsylvania, Philadelphia, PA, United States, 2Weill Medical Coll of Cornell NY, New York, NY, United States |
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Adverse remodeling after a myocardial infarct has been linked to the elevated wall stress in the myocardium adjacent to the infarct (i.e. border zone). Perturbed metabolism in this region could drive the transition from compensated to adverse remodeling. To evaluate regional metabolism this study compared the uptake and intracellular conversion of [1-13C]pyruvate using hyperpolarized 13C. An infarct model of ventricular remodeling was used to investigate region metabolism. Pharmacologic stress produced an increase in remote metabolite flux compared to border zone region which may provide a metabolic mechanism for the established association of mechanical stress and adverse cardiac remodeling following infarct. |
| 1055 | 9:36
|
Transient intrinsic torsional shear wave propagation demonstrates a difference in Left Ventricular Myocardial stiffness between volunteers and patients with HFpEF |
1King's College London, London, United Kingdom, 2Guys and St Thomas' NHS Trust, London, United Kingdom, 3Universitat Ramon Llull, Barcelona, Spain, 4Philips Healthcare, Guildford, United Kingdom |
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Heart Failure with preserved Ejection Fraction is common, associated with high morbidity and mortality, and is challenging to diagnose. We have developed a novel patient friendly non-invasive technique to quantify myocardial stiffness using transient MR Elastography. Aortic valve closure results in the propagation of a transient shear wave through the myocardium. Torsional wave propagation can be visualised using a 1D pencil beam navigator positioned longitudinally along the myocardial septum, using four breath holds each 15 seconds. Providing a temporal resolution of 0.3ms, we observe increased myocardial stiffness in HFpEF patients compared to healthy volunteers (torsional speed 5.5 ± 1.1 m/s in volunteers and 10.0 ± 0.7 m/s in Patients; stiffness 36 ± 12.0 kPa and 108 ± 15.2 kPa, respectively) . |
| 1056 | 9:48
|
Simultaneous Multi-Slice (SMS) Cardiac CINE using embedded Hadamard-encoded reference data at 7 Tesla |
1CRMBM, Aix Marseille University CNRS, Marseille, France, 2Siemens Healthineers, Saint Denis, France, 3Aix-Marseille Univ, CNRS, CRMBM, Marseille, France |
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To perform high-resolution cardiac function MRI, thin-slice Cine MRI at 7T is accelerated using Simultaneous Multi-Slice (SMS) technique. Additionally, Hadamard encoding strategy along the temporal dimension is superimposed on the CAIPIRINHA phase shift. The Hadamard-decoded data serve as embedded reference for SMS image reconstruction. Additional in-plane L1-SPIRiT reconstruction allows for limited noise amplification. Results show excellent slice separation, satisfactory SNR and CNR for assessment of cardiac function. However, SAR restrictions impose a lower flip angle for SMS acquisitions that result in poorer blood-to-myocardium contrast. |
| S05 | Thursday 8:00 - 10:00 | Moderators: Borjan Gagoski & Zhong Chen |
| 1057 | 8:00
|
Reduction of Acquisition time by Partition of the sIgnal Decay in Spectroscopic Imaging (RAPID-SI) technique: Preliminary In-vivo results and comparison with CSI. |
1Department of Radiology and nuclear medicine, University of Ghent, Gent, Belgium, 2Robarts Research Institute, University of Western Ontario, London, ON, Canada |
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We describe the development of the RAPID-SI technique and its implementation on a 3 T Siemens scanner. In-vivo studies demonstrate the performance of this technique in terms of acquisition time, signal-to-noise ratio, and data analysis. The results are compared to the CSI technique. Compared to CSI, RAPID reduces the acquisition time by a factor of R and provides accurate quantification results. The SNR of RAPID at the acquisition level is lower by √R and increased by data pre-processing. Quantification results of RAPID-SI are comparable to the CSI ones. The study shows that RAPID-SI provides accurate metabolite quantification results while significantly reducing acquisition time in obtaining MRSI data similar to CSI in terms of resolution and sensitivity. |
| 1058
|
8:12
|
Further Accelerating SPICE for Ultrafast MRSI Using Learned Spectral Features |
1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States |
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This work presents a new method to incorporate machine learning into SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation) to further enhance its data acquisition speeds. The proposed method exploits the significant amount of prior knowledge about the spectral variations of biological tissues, e.g., molecular composition and resonance structures, by devising a novel strategy to learn the molecule-specific spectral features from training data, and incorporating the learned features into a subspace representation of the desired spatiospectral distribution for a general MRSI study. Impressive results have been produced by the proposed method from 1H-MRSI of the brain without any suppression pulses. |
| 1059 | 8:24
|
Combining multi-band slice selection with COKE (COherent K-t-space EPSI) for accelerated spectral imaging |
1Radiology, Leiden University Medical Center (LUMC), Leiden, Netherlands, 2Neurobiology, Weizmann Institute of Science, Rehovot, Israel, 3Chemical physics, Weizmann Institute of Science, Rehovot, Israel |
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One of the powerful techniques for faster spectroscopic imaging acquisition is so called proton echo planar spectroscopic imaging (EPSI). An alternative method, which we here term COKE (COherent K-t space EPSI), relies on interleaving “blipped” PE gradients in between readouts to produce coherent phase between the k-t space lines. COKE enables to double the SW in comparison to EPSI or to halve the acquisition duration. We designed a sequence that integrates a multi-band CAIPIRINHA with COKE acquisition for faster spectroscopic imaging. This was demonstrated in both phantoms and in-vivo. |
| 1060 | 8:36
|
MEGA-SPICE: A subspace-based approach to high-resolution spectral edited MRSI |
1Gordon Center for Medical Imaging, Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 2Nuclear Medicine, West China Hospital, Sichuan University, Sichuan, China |
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Spectral edited MRS/MRSI is a powerful tool to detect metabolites with J-coupled spins (e.g., GABA and 2-HG) that are otherwise overlapped with other high concentration metabolites (e.g., Cho and Cr). Compared to conventional MRSI, it is even more challenging to achieve high-resolution spectral edited MRSI because of lower metabolite concentration and less time-efficient spatial-spectral encoding. A subspace-based approach, called SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation), has been proposed for high-resolution MRSI, producing 3D MRSI images at 3 mm isotropic resolution within 10 mins. We present here a method, termed MEGA-SPICE, for accelerated high-resolution spectral edited MRSI, which is enabled by spectral editing using MEGA pulses and subspace-based data acquisition and processing strategies. |
| 1061 | 8:48
|
Elliptical Localization with Pulsed Second-Order Fields (ECLIPSE) for Robust Lipid Suppression in Proton MRSI |
1MRRC, Yale University, New Haven, CT, United States |
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Proton MRSI has great clinical potential for metabolic mapping of healthy and pathological human brain. However, technical challenges related to poor spectral quality caused by magnetic field inhomogeneity, limited RF transmit power and incomplete lipid suppression have dampened the utility of MRSI. Here a novel method for lipid suppression is presented based on localization of an elliptical region-of-interest using pulsed second-order magnetic fields. A high-amplitude gradient setup was designed and constructed, containing coils to generate Z2, X2Y2 and XY magnetic fields. Simulations, phantom MRI and MRSI on human brain in vivo demonstrate robust localization and suppression of extracranial lipids. |
| 1062 | 9:00
|
Dynamically Switched B0 Field Control for Separate Optimization of Tailored Volume Lipid Suppression and B0 Homogeneity for Brain Chemical Shift Imaging at 3T using Multi-Coil Shim Array |
1Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 2A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospita, Charlestown, MA, United States, 3Department of Radiology, Harvard Medical School, Boston, MA, United States, 4Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, 5Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States |
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A rapidly reconfigurable 32-channel local-multi-coil-shim-array is used to both enhance lipid suppression and narrow metabolite linewidth in chemical-shift imaging of the brain. Using in-situ optimization, the array is first configured to widen the spectral gap between spatially separate lipid and metabolite regions, to improve lipid-surpressing inversion, and then reconfigured for field homogeneity, to narrow metabolite linewidth during readout. For 2cm thick brain slab, using the dynamically-reconfigured array reduced lipid contamination by 24.5%, reduced linewidth by 34%, and increased well-imaged brain area by 38% over static 2nd order shimming |
| 1063 | 9:12
|
Dynamic Spatially Selective Dephasing for Outer Volume Suppression |
1Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States, 2Radiology, University of Pittsburgh, Pittsburgh, PA, United States |
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A novel dynamic spatially selective dephasing (DSSD) for outer volume suppression (OVS) is introduced. This technique uses high-order shim pulses to accomplish OVS by creating a low and high field gradient within and outside of region of interest. The effectiveness of DSSD is investigated with phantom and human using an 8-channel parallel transmit 7 Tesla Siemens system. Similar suppression performance was obtained in phantom and human brain using DSSD with a circular and an elliptical shape, respectively. The results show that OVS can be achieved by using a high degree shim insert to generate a steep B0 gradient at periphery of target region. |
| 1064 | 9:24
|
Reproducibility and clinical feasibility of diffusion-weighted MRS using sLASER and STEAM in the human brain in vivo at 3T |
1Brain and Spine Institute (ICM), Center for Neuroimaging Research (CENIR), Paris, France, 2Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Inserm U 1127, CNRS UMR 7225, Paris, France, 3Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 4C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands |
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Diffusion-weighted MR spectroscopy (DW-MRS) allows disentanglement of different pathological mechanisms of brain tissue by exploiting the specific compartmentation of metabolites in different cell types. In this study, we estimated the reproducibility of metabolite diffusion measures obtained using DW-sLASER and DW-STEAM sequences at 3T. The inter- and intra-subject variability of the apparent diffusion coefficients (ADC) of the three major metabolites, as well as the effect of the acquisition time on the variance of these measures were calculated for both sequences in two brain regions. Power calculations were performed to facilitate the choice of the optimal protocol for specific clinical needs. |
| 1065 | 9:36
|
Direct signal detection of exchangeable protons of metabolites with high SNR using ultrashort-TE, short-TR 1-H MRSI without water presaturation |
1FB02 (Chemistry), University of Bremen, Bremen, Germany, 2Inegrative Ecophysiology, Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research, Bremerhaven, Germany |
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Chemical exchange saturation transfer (CEST) is a powerful technique for inverse metabolic imaging and non-invasive pH measurements, and is most efficient in the intermediate exchange regime between protons of metabolites and water. We examined the use of ultrashort-TE, short-TR MRSI for the direct signal detection of exchangeable protons of metabolites. If water is not saturated, fresh z-magnetization is transferred to the protons of metabolites, allowing a high SNR despite short TR. This approach was evaluated by simulations and measurements on creatine phantoms using solutions with different pH, demonstrating direct signal detection for exchange rates up to ~1000 s-1. |
| 1066 | 9:48
|
Water suppression in the human brain with hypergeometric RF pulses for single- and multi- voxel MR spectroscopy |
1Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States, 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States, 3F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 4Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, United States |
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In this study, a novel water suppression sequence with hypergeometric RF pulses (HGWS) is investigated and compared to the commonly used VAPOR sequence in simulations, single and multi- voxel acquisitions. In simulations, HGWS and VAPOR are insensitive to B1 and water T1 variations, but with no B1 variation, HGWS has a lower average residual water fraction than that of VAPOR. In vivo, HGWS provides better water suppression than VAPOR in both single-voxel and multi-voxel acquisitions with a shorter sequence duration. |
| S06 | Thursday 8:00 - 10:00 | Moderators: Thomas Royston & Jeong Hee Yoon |
| 1067
|
8:00
|
Altered brain tissue stiffness in pediatric cerebral palsy measured with magnetic resonance elastography |
1Biomedical Engineering, University of Delaware, Newark, DE, United States, 2Psychological and Brain Studies, University of Delaware, Newark, DE, United States, 3Orthopedics, Nemours Alfred I. duPont Hospital for Children, Wilmington, DE, United States, 4Department of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, United States |
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Magnetic resonance elastography (MRE) measures the viscoelastic mechanical properties of tissues, which vary extensively between normal and disease states. In this study, we hypothesized that the mechanical integrity of brain tissue is reduced in children with cerebral palsy (CP). Through MRE, we found the stiffness of the cerebrum in children with CP ages 5-12 is significantly lower than in typically developing (TD) children. This finding indicates that there is a difference in brain tissue health in children with CP that is quantifiable through stiffness measured with MRE. |
| 1068
|
8:12
|
Imaging Visual Cortex Activity with Intrinsic Activation MRE |
1Department of Diagnostic Radiology, University of Sherbrooke, Sherbrooke, QC, Canada, 2Department of Mechanical Engineering, University of Sherbrooke, Sherbrooke, QC, Canada |
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Initial RD-MRE results from intrinsic activation during repeated ON-OFF visual stimulation cycles are presented. Processed probability values from independent t-tests show areas of isolated activity in the region of the visual cortex for certain mechanical parameters, including the real shear modulus and the imaginary bulk modulus. Overlays of these probability value images with co-registered BOLD images show complimentary regions of activation. |
| 1069
|
8:24
|
Assessing tumor mechanical properties and blood perfusion with MRI and correlation with tumor pressure at different compression levels in mice |
1Laboratory of Imaging Biomarkers, UMR1149, INSERM-University Paris Diderot, Paris, France, 2Sanofi Aventis, Vitry-Sur-Seine, France, 3Department of Radiology, Beaujon University Hospital Paris Nord, Clichy, France |
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The purpose of this study was to evaluate the changes of total tumor pressure and mechanical properties as a function of increasing stress. MR elastography and perfusion measurements (FAIR method) were performed in mice with tumors xenografted subcutaneously. Tumor pressure was measured with a catheter-transducer system. Measurements were performed at different stress levels by externally compressing the tumor with an inflatable balloon. The results show that increasing the externally applied compression results in increased mechanical properties and tumor pressure and decreased perfusion. These results suggest that elevated tumor pressure can be explained by solid stress rather than fluid pressure. |
| 1070 | 8:36
|
Multi-Excitation MRE in Aging Human Brain |
1Mechanical Science & Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Biomedical Engineering, University of Delaware, Newark, DE, United States, 4Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 5Département de génie mécanique, Université de Sherbrooke, Sherbrooke, QC, Canada, 6Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States |
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The adult aging process affects human brains in different ways and becomes more prone to neurodegenerative diseases. MRE has shown it’s sensitivity to both changes within healthy brains and identifying biomarkers in diseased brains. This study builds on previous MRE aging research and adds higher-resolution, full-coverage MRE imaging and the ability to identify tissue anisotropy, or lack thereof, with the multi-excitation experiment. We were able to identify important anisotropic differences in the loss modulus for some white matter (WM) regions within the young group and a loss of group-level anisotropy in the select WM regions in the older group. |
| 1071 | 8:48
|
Hemispheric specialisation of hippocampal viscoelasticity for memory performance in healthy older adults |
1Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom, 2Edinburgh Imaging Facility, QMRI, University of Edinburgh, Edinburgh, United Kingdom, 3Department of Biomedical Engineering, University of Delaware, Newark, DE, United States, 4Thayer School of Engineering, Dartmouth College, Hanover, NH, United States, 5Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana-Champaign, IL, United States |
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MR Elastography of the hippocampus has been associated with memory performance in young adults and thus may have potential as a novel imaging biomarker for Alzheimer’s disease (AD). In healthy older-adults, hippocampal damping ratio ξ was significantly associated with performance on a verbal memory task. Due to greater hippocampal atrophy present in older populations, the contributions of voxels containing CSF were analysed. Stronger correlations with memory were found once CSF voxels were excluded, and when the left hippocampus was analysed separately. MRE of the hippocampus may be a sensitive marker for detecting early pathological changes in patients with AD. |
| 1072 | 9:00
|
In Vivo Characterization of 3D Skull and Brain Motion using MR Elastography with Multi-Excitation Head Driver |
1Radiology, Mayo clinic, Rochester, MN, United States |
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Characterization of skull-brain interactions during applied motion is essential to understanding the mechanics of traumatic brain injury. In this study, MR elastography was performed on volunteers to study in vivo skull-brain motion responding to different vibrational directions using a multi-excitation driver. With novel dual-saturation imaging and dual-sensitivity motion encoding schemes, we directly measured relative skull-brain displacement on a voxel basis. Our results show that the skull-brain interface tends to significantly attenuate and delay rotational motion compared to translational motion. In slip interface imaging, the skull-brain slip interface is not completely evident, and the slip pattern is spatially heterogeneous. |
| 1073
|
9:12
|
Ultra-Fast 4D MR Elastography using Down-Stream Echoes |
1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2Division of Research Oncology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, 3Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom |
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We propose the readout of the lowest order SSFP echo also referred to as down-stream echo of a phase-locked, spoiled SSFP sequence and utilize the unbalanced gradient moment as a highly efficient motion encoding gradient for ultra-fast MRE and demonstrate its feasibility for rapid breast MRE. |
| 1074 | 9:24
|
In Vivo MR Elastography in Abdominal Aortic Aneurysm Porcine Model: A Comparison to Burst Testing and Mechanical Testing |
1Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, United States, 2Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States, 3Dorothy M. Davis Heart and Lung Research Institute Interventional Cardiology Catheterization Core Lab, The Ohio State University Wexner Medical Center, Columbus, OH, United States, 4Center for Biostatistics, The Ohio State University, Columbus, OH, United States |
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Abdominal aortic aneurysm (AAA) can result in death due to rupture. Aortic stiffness is an important biomechanical property that can potentially provide accurate rupture risk evaluation. MR elastography (MRE) is a non-invasive technique to estimate aortic stiffness and has not been validated. Therefore, the aim of this study is to use in vivo aortic MRE to estimate aortic stiffness in AAA-induced animal models, and compare it with mechanical testing as well as burst testing. Results demonstrated that aortic stiffness was significantly higher in AAA when compared to normal aorta, while bursting pressure and peak stress was significantly lower in AAA. |
| 1075 | 9:36
|
Respiratory-triggered (RT) spin-echo echo-planar imaging (SE-EPI) based MR Elastography (MRE) |
1Philips, Cincinnati, OH, United States, 2Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 3Philips, Wickliffe, OH, United States |
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In this work, we describe the development of respiratory-triggered (RT) SE-EPI MR elastography (MRE) and its validation with respect to breath-hold (BH) SE-EPI MRE in adult volunteer subjects. |
| 1076 | 9:48
|
Usage of Octahedral Shear Strain Weights in the Inversion of Multifrequency MR Elastography |
1Department of Electrical and Electronics Engineering, Bilkent University, Ankara, Turkey, 2National Magnetic Resonance Research Center (UMRAM), Ankara, Turkey, 3Radiological Sciences, Charité - Universitätsmedizin Berlin, Berlin, Germany, 4Department of Electrical and Electronics Engineering, TOBB-University of Economics and Technology, Ankara, Turkey |
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Multifrequency MR elastography (MMRE) is useful for compensating the influence of amplitude nulls on the elastogram by combining computations at different frequencies by amplitude-weighted averaging or directly without using weights. Previously, it was shown that strain‑SNR measures the quality of the data for reconstructing accurate elastography maps. Therefore, using octahedral shear strain (OSS) weights may lead to more accurate elastograms. In this study, k-MDEV and multifrequency Helmholtz inversion have been used. Including OSS-weights in the inversions yielded more reliable elastograms for simulation and experiment phantom. Furthermore, elastograms in higher resolution were obtained for the brain model and human brain data. |
| W05/06 | Thursday 8:00 - 10:00 | Moderators: Simon Veldhoen & Yoshiharu Ohno |
| 1077
|
8:00
|
Motion-resolved UTE based Pulmonary Quantitative Susceptibility Mapping |
1Bioengineering, UCSF&UC Berkeley, San Francisco, CA, United States, 2Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 3Department of Electrical Engineering and Computer Sciences, UC Berkeley, Berkeley, CA, United States, 4Department of Medical Physics, University of Wisconsin, Madison, Madison, WI, United States, 5Department of Radiology, University of Wisconsin, Madison, Madison, WI, United States, 6Heartvista Inc., Los Altos, CA, United States, 7Department of Radiology, Stanford University, Stanford, CA, United States |
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Pulmonary MRI is challenging due to many factors, such as short T2* relaxation time and respiratory motion corruption. However, the large susceptibility differences in the lungs from blood oxygenation and O2 content might provide more information related to pulmonary function. In this work, we combined ultra-short TE(UTE) acquisition, quantitative susceptibility mapping(QSM), and motion-resolved reconstruction techniques together to look at the susceptibility contrast in the lung and changes in different motion states. According to the results, this technique provides extra contrast information compared to traditional intensity images, and shows susceptibility changing of lung in different respiration states. |
| 1078 | 8:12
|
Repeatability of ventilation and perfusion impairment assessed with matrix pencil decomposition MRI and lung function in children with cystic fibrosis |
1Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland, 2Department of Biomedical Engineering, University of Basel, Basel, Switzerland, 3Pediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, 4Departement of Diagnostic, Interventional and Paediatric Radiology, Inselspital, University Hospital Bern, Bern, Switzerland |
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This study examines the repeatability of functional lung MRI using matrix pencil decomposition and lung function tests with multiple breath washout technique in children with cystic fibrosis and age-matched healthy controls. We found a good degree of the agreement between outcomes measured on two consecutive days in both groups. Furthermore, a strong correlation between functional MRI and global ventilation inhomogeneity index from multiple breath washout was observed. The results of this study highlight the potential of matrix pencil decomposition MRI for the assessment of disease progression in cystic fibrosis |
| 1079 | 8:24
|
Imaging-Based Spirometry in Chronic Obstructive Pulmonary Disease (COPD) Patients using Phase Resolved Functional Lung Imaging (PREFUL) |
1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hanover, Germany, 3Clinical Airway Research, Fraunhofer Institute of Toxicology and Experimental Medicine, Hanover, Germany |
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Recently, an alternative proton lung MRI Fourier Decomposition (FD) method for phase resolved functional lung imaging (PREFUL) was proposed. Using a sine model, respiratory and cardiac cycles with increased temporal resolution are obtained, enabling the assessment of dynamic parameters. Similar to flow-volume loops in spirometry, the regional ventilation can be quantified in terms of fractional ventilation (FV) loops. In this study the FV loops of six healthy volunteers and 16 chronic obstructive pulmonary disease patients are evaluated. As a metric the cross-correlation to a healthy reference is used. The results suggest potential benefits for early detection or treatment monitoring. |
| 1080 | 8:36
|
Pulmonary MRI Measurements of Ventilation Heterogeneity in Obstructive Lung Disease: Relationship to Oscillometry, Quality of Life and Disease Control |
1Robarts Research Institute, London, ON, Canada, 2Medical Biophysics, Western University, London, ON, Canada, 3Graduate Program in Biomedical Engineering, Western University, London, ON, Canada, 4School of Biomedical Engineering, Dalhousie University, London, ON, Canada |
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We measured ventilation heterogeneity in 100 patients (50 asthma, 50 COPD) with hyperpolarized 3He MRI, oscillometry and quality-of-life questionnaires. We showed that MRI-measured ventilation heterogeneity is significantly related to FOT-measured small airways resistance and worsened quality-of-life for asthma and COPD patients. We also showed that MRI-measured ventilation heterogeneity is significantly increased in asthmatic patients with poor disease control. This study directly demonstrates the relationships between 3He MRI ventilation heterogeneity with small airway dysfunction and patient quality-of-life. |
| 1081 | 8:48
|
Altered Right-Heart 3D Blood Flow and Kinetic Energy in Chronic Obstructive Pulmonary Disease. The MESA COPD Study |
1Department of Medical Imaging, Lurie Children's Hospital, Chicago, IL, United States, 2Department of Radiology, Northwestern University, Chicago, IL, United States, 3Department of Medicine and Epidemiology, Columbia University, New York, NY, United States, 4Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, 5Department of Radiology, Weill Cornell Medical College, New York, NY, United States, 6Department of Radiology, Columbia College of Physicians and Surgeons, New York, NY, United States, 7Division of Cardiology, John Hopkins University, Baltimore, MD, United States, 8Department of Medicine, UCLA, Los Angeles, CA, United States |
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Chronic Obstructive Pulmonary Disease (COPD) affects over 65 million people worldwide and is the third leading cause of death in the US. The aim of this feasibility study was to employ 4D-flow MRI for the comprehensive assessment of the effects of COPD on right-sided hemodynamics. Measures of blood kinetic energy (KE) were used to quantify hemodynamic changes in COPD patients compared to controls. Findings showed a significant increase in KE in the right atrium across increasing categories of COPD severity. Right-sided 4D flow MRI maybe a promising tool for the detection of hemodynamic disruptions in COPD and other vasoconstrictive diseases. |
| 1082 | 9:00
|
A Technique for Quantitatively Measuring Gas Uptake in the Lung and its Distribution to the Kidneys Using Hyperpolarized Xenon-129 MR Imaging |
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Physiology, University of Pennsylvania, Philadelphia, PA, United States, 3Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States |
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Hyperpolarized 129Xe was used before to image lung function and structure. It was also shown to be a very good marker of oxygen diffusion and uptake from the lung, and a surrogate for alveolar wall thickness. Here, we demonstrated a technique for quantitatively measuring gas uptake in the lung and its distribution to the kidney and calculate the arrival time of the gas to the kidneys. Appropriate acquisition parameters will enable the same technique to be used to measure the gas’ arrival at the heart, specific vasculature, or other organs/tissue as appropriate to specific disease states. |
| 1083 | 9:12
|
Hyperpolarised gas MRI shows a decrease in lung ventilation defects at increased inspiratory lung volumes in Cystic Fibrosis |
1POLARIS, Academic Radiology, University of Sheffield, Sheffield, United Kingdom, 2Sheffield Children's Hospital NHS Foundation Trust, Sheffield, United Kingdom, 3University of Manchester, Manchester, United Kingdom |
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The effect of lung inflation level on ventilation defects, using hyperpolarised (HP) gas ventilation MRI, has not been assessed. The most commonly adopted method of inhaling a volume of 1L from functional residual capacity (FRC) will result in a lung volume closer to total lung capacity (TLC) for smaller people, compared with taller people. We assessed HP-MRI in 21 people with cystic fibrosis at both end inspiratory tidal volume (EIVt) and at TLC. Ventilation defects decreased in all subjects at TLC when compared to EIVt and therefore the inspiratory volume should be carefully considered when interpreting ventilation-imaging results. |
| 1084 | 9:24
|
Quantification of gas concentration and fractional ventilation using high temporal resolution MRI of pulmonary fluorinated (19F) gas washin dynamics in free breathing |
1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Germany |
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19F gas washin/ washout MRI allows quantification of regional lung ventilation in free breathing even in obstructed lungs. By increasing the temporal and spatial resolution of dynamic 19F gas MRI at adequate image quality lung ventilation imaging was improved. In addition to measuring regional gas washin/ washout times, gas density variations during breathing were determined, giving further information of gas dynamics and therefore lung function. Additionally, the concentration of the fluorinated gas tracer and therefore its distribution in the lung was quantified. The new approaches were tested in a healthy volunteer and a COPD patient. |
| 1085 | 9:36
|
Comparing 19F C3F8 Lung Ventilation Imaging with Hyperpolarized 129Xe: Similarities and Limitations |
1POLARIS, Academic Radiology, University of Sheffield, Sheffield, United Kingdom, 2GE Healthcare Inc., Aurora, OH, United States |
||
Fluorinated gases are a cheaper alternative to hyperpolarized gas for lung ventilation imaging. However, lower resolution images are necessitated by the inherently smaller MR signal from 19F. Within this study we determine the feasibility of using C3F8 for lung ventilation imaging by comparing quantitative metrics of lung function obtained from ventilation images of 19F with those obtained from ventilation images of hyperpolarized 129Xe. A reproducibly lowered coefficient of variation distribution was observed due to lower resolution of 19F imaging. However, ventilation images acquired with 19F were of comparable SNR to those using 129Xe. |
| 1086 | 9:48
|
Dynamic 3D Isotropic Resolution Imaging of Human Lungs Using Oxygen-enhanced Radial UTE MRI |
1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States |
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Oxygen-enhanced 3D radial UTE MRI (UTE OE-MRI) has the potential for dynamic imaging of oxygen wash-in and wash-out in the lungs with isotropic resolution and full chest coverage. Four normal subjects underwent DESPOT1 and ~13-min dynamic OE-MRI using 3D radial UTE MRI. Temporal variations in median percent signal enhancement (MPSE) strongly correlated (p<0.0001) in the lungs and aorta. Wash-in (0.61±0.13 min) and wash-out (0.30±0.18 min) time constants for partial pressure of oxygen (ΔPO2) time curves are comparable to values in the literature. This study shows feasibility for dynamic imaging with whole lung coverage and isotropic spatial resolution for clinical research. |
| W07 | Thursday 9:00 - 10:00 | (no CME credit) |
Organizers: Elena Kaye, Anke Henning, Jenny Bencardino, Alex MacKay
| Plenary Hall (Paris Room) | Thursday 10:15 - 11:45 | Moderators: Anke Henning & Elena Kaye |
| 10:15 | High-End MRI: Added Value |
1Medical University of Vienna, Austria |
| 10:35 | High-End MRI: Added Science |
1FMRIB Centre, University of Oxford, United Kingdom |
| 10:55 | A Case Study: Interventional MRI: Prostate cancer diagnosis |
1Brigham & Women's Hosp. Prof. of Rad., United States |
| Plenary Hall (Paris Room) | Thursday 11:15 - 11:45 | Moderators: Julien Cohen-Adad & Jessica Dubois |
| 1087 | 11:15
|
Creatine kinase energy supply correlates with mechanical work and efficiency in healthy and failing human heart: a combined noninvasive MRI/MRS study |
1Division of MR Research, Department of Radiology, The Johns Hopkins University, Baltimore, MD, United States, 2Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX, United States, 3Systems and Biomedical Engineering, Faculty of Engineering, Cairo University, Cairo, Egypt, 4Department of Cardiology, The Johns Hopkins University, Baltimore, MD, United States |
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It is hypothesized that chemical energy supply is insufficient to fuel normal mechanical pump function in heart failure (HF). To test whether reduced function correlates with reduced energy supply, we used magnetic resonance spectroscopy and imaging to measure adenosine triphosphate (ATP) synthesis via the creatine kinase reaction–the heart’s primary reserve–and cardiac mechanical stroke work in 14 healthy subjects and 27 patients with mild-to-moderate HF. We found significantly reduced cardiac creatine kinase flux that correlated with peak and average stroke work rates and with mechanical efficiency. These first noninvasive findings are consistent with the energy deprivation hypothesis of HF. |
| 1088
|
11:21
|
Metabolomic Evaluations of Human Prostate Tissue from mp-MRI/US Fusion Biopsy |
1Pathology, Massachusetts General Hospital, Charlestown, MA, United States, 2Radiology, University of Wurzburg, Wurzburg, Germany, 3Oncology, Charite Medical University, Berlin, Germany, 4Urology, Massachusetts General Hospital, Boston, MA, United States |
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Heterogeneity and clinical insignificance of prostate cancer (PCa) lesions challenges diagnosis and management. Introduction of the multi-parameter (mp)-MRI/ultrasound fusion-guided biopsy increased detection of clinically significant cancer. Prostate MRI lesions receive a PI-RADS score based on likelihood of being cancer-positive. Fusing MRI images with live ultrasound guides biopsy from the targeted area. Previously, PI-RADS score has been correlated with clinical significance of cancer and morphological variations in PCa lesions. We studied PI-RADS score according to tissue MRS-based metabolomics. Metabolic differences between Target and Non-target cores, regardless if Targets were cancer-positive, support the assumption that targeted areas fundamentally differ from non-targeted areas. |
| 1089
|
11:27
|
In vivo MRI detection of early β-amyloid pathologies targeted by curcumin-conjugated magnetic nanoparticles |
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China |
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Early state β-amyloid oligomers (AβOs) and |
| 1090 | 11:33
|
Tensor-valued diffusion MRI in under 3 minutes: An initial survey of microscopic anisotropy and tissue heterogeneity in four brain tumor types |
1Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden, 2Random Walk Imaging, Lund, Sweden, 3Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States |
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Microscopic diffusion anisotropy and tissue heterogeneity are two independent features of tumor microstructure that can be probed by diffusion MRI but only by using so-called b-tensor encoding. These independent features reflect cell shapes and cell density variance in tumors. Here, we demonstrate high-quality maps of these features, derived from data acquired in only 3 minutes, in patients with various brain tumor histologies. Several remarkable features were observed which suggest that the maps may contribute valuable diagnostic information, in particular since the features vary both within and between tumors. |
| 1091
|
11:39
|
Variational Adversarial Networks for Accelerated MR Image Reconstruction |
1Institute of Computer Graphics and Vision, Graz University of Technology, Graz, Austria, 2Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States, 3Safety & Security Department, AIT Austrian Institute of Technology GmbH, Vienna, Austria |
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Inspired by variational networks and adversarial training, we introduce variational adversarial networks for accelerated MR image reconstruction to overcome typical limitations of using simple image quality measures as loss functions for training. While simple loss functions, such as mean-squared-error and structural similarity index, result in low resolution and blurry images, we show that the proposed variational adversarial network leads to sharper images and preserves fine details for clinical low and high SNR patient data. |
| Plenary Hall (Paris Room) | Thursday 12:00 - 13:00 | (no CME credit) |
| Exhibition Hall 2896-2923 | Thursday 13:15 - 15:15 | (no CME credit) |
| Exhibition Hall 3020-3032 | Thursday 13:15 - 15:15 | (no CME credit) |
| Exhibition Hall | Thursday 13:15 - 14:15 | (no CME credit) |
| Exhibition Hall | Thursday 13:15 - 15:15 | (no CME credit) |
| W07 | Thursday 13:15 - 14:15 | (no CME credit) |
Organizers: Thoralf Niendorf, Nicola De Zanche, Cornelis van den Berg
| N04 | Thursday 13:15 - 15:15 | Moderators: Thoralf Niendorf & Nicola De Zanche | (no CME credit) |
13:15
|
Insights from 7.0 T MRI in a Clinical Environment: The User's View | |
1Lund University Bioimaging Center, Lund University, Lund, Sweden |
13:32
|
Clinical Applications of 7.0 T MRI & the Inescapable Attraction of Even Higher Fields: The Clinician's View | |
1University Medical Center Utrecht, Netherlands |
13:49
|
Parallel Transmission at 10.5 T: The MR Physics Perspective | |
14:06
|
How to Build a 11.7 T Class Human Brain MR System: The Engineering Insights | |
1CEA Neurospin, France |
14:23
|
Magnet Design for 14.0 T & 20.0 T Class Human MR Scanners: The Engineering Angle | |
14:40
|
RF Coil Concepts & RF Power Deposition Considerations for Human MR at 23.5 T | |
1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine, Berlin, Germany |
14:57
|
Implant Safety on the Ultrahigh Field Frontier: Is It a Rodeo Ride? | |
Organizers: Arnaud Comment, Bastiaan Driehuys, Christoffer Laustsen
| W03/04 | Thursday 13:15 - 15:15 | (no CME credit) |
13:15
|
Multisite Clinical Trials with Hyperpolarized X-Nuclei: 129Xe Leads the Way | |
1McMaster University, Hamilton, ON, Canada |
13:37
|
Moving to Clinical Applications of Hyperpolarized Gas MRI: Successes & Challenges | |
1University of Sheffield |
13:59
|
On the Challenges to Translate Preclinical HP 13C Models to Clinical Applications | |
1MSKCC, NY, United States |
14:21
|
The Challenges of Directly Developing Hyperpolarized 13C MRI in a Clinical Environment | |
14:43
|
Panel Discussion |
Organizers: Dong-Hyun Kim, Joshua Trzasko
| N02 | Thursday 13:15 - 15:15 | Moderators: Dong-Hyun Kim & Joshua Trzasko |
13:15
|
What Is Quantitative Imaging? | |
1Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States |
13:55
|
Walk-Through | |
1NIST, United States |
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This talk will present how to use and pick a phantom for specific applications, how the phantom can identify possible pitfalls or sources of error, and how to perform reproducibility and reliability studies. |
14:35
|
Quantitative relaxation time measurements in MSK: Clinical use and quality control | |
1Medical University of Vienna, Austria |
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Quantitative MRI provides information that is intrinsically more tissue-specific and less dependent on subjective visual assessment. The quantitative data can also be postprocessed such as segmentation based on biophysical properties and anatomy, distribution histograms, and synthetic MR images. In clinical applications T1 and T2 mapping offer early diagnosis of disease and a predictive marker for outcome. T1 mapping has become part of a routine cardiac MR imaging protocol. However many factors can cause systematic errors that can compromise the accuracy of the T1 and T2 maps and a high variability of relaxation times in different tissues has been reported. |
15:15
|
Adjournment & Meet the Teachers |
Organizers: Kathryn Fowler, Catherine Hines, Kartik Jhaveri, Lorenzo Mannelli, Valeria Panebianco, Scott Reeder, Reiko Woodhams
| S01 | Thursday 13:15 - 15:15 | Moderators: James Quirk & Chi Wan Koo |
13:15
|
Hyperpolarized Gas: Clinical Applications or No? | |
1Edinburgh Imaging, University of Edinburgh, Edinburgh, United Kingdom |
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Hyperpolarized gas MR imaging has shown promising results since its first evaluations began in the mid 1990s. However, after implementation of hyperpolarized 3-He MRI was showing of interest, conflicts with other fields requiring this gas made long-term application and translation impossible. This has driven developments of 129-Xe MRI as an alternative, and following hardware, polarization and sequence changes, this method is now surging in applications and is being used for a variety of pathophysiological processes (that even go beyond the lung). This presentation will highlight some of the latest developments and will offer a glimpse at the future of hyperpolarized 129-Xe MRI. |
13:45
|
MRI for Stratifying Pulmonary Vascular Disease | |
1Radiology, University of Wisconsin-Madison, Madison, WI, United States |
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This presentation will review the role of pulmonary MRA and cardiac MRI in the diagnosis and management of patients with pulmonary vascular disease. The primary focus will be on the identification of the signs of pulmonary hypertension on MRA and the findings of right ventricle dysfunction in patients with pulmonary vascular disease. |
14:15
|
MRI for Pulmonary Parenchymal Disease (COPD, IPF) | |
1Medizinische Hochschule Hannover, Germany |
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Chronic obstructive pulmonary disease (COPD) and interstitial pulmonary fibrosis (IPF) are heterogeneous diseases with different features and phenotypes. Accordingly, one goal is the development of ways to identify regional lung structure and function in these patients to improve patient care and outcomes. Although forced vital capacity is validated for the assessment of COPD and IPF progression and prediction of mortality, the need for tests that are more sensitive to pathophysiological change in the lungs is well recognized for earlier diagnosis, longitudinal assessment and for better markers of therapy and prognosis. |
14:45
|
Oxygen-Enhanced MRI: Ready for Clinical Use? | |
1Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe Univ. Grad. Sch. of Med., Kobe, Japan, 2Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Japan |
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In this lecture, I present 1) theory of oxygen-enhancement; 2) clinical study results; and 3) future direction and new technique for oxygen-enhanced MR imaging. |
15:15
|
Adjournment & Meet the Teachers |
| Power Pitch Theater A - Exhibition Hall | Thursday 13:15 - 14:15 | Moderators: Sune Jespersen & Clémence Ligneul | (no CME credit) |
| 1092 | 13:15
|
Probing microstructure with different tomographic methods: Comparing dMRI and X-ray scattering-derived parameters in mouse and human brains |
1NYU Langone Medical Center, New York, NY, United States, 2ETH Zurich, Zurich, Switzerland, 3Paul Scherrer Institute, Villigen, Switzerland, 4Chalmers University of Technology, Gothenburg, Sweden |
| 1093 | 13:15
|
Diffusion-time dependence of diffusional kurtosis in the mouse brain using pulsed and oscillating gradients |
1Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States |
| 1094
|
13:15
|
Biophysical modeling of the gray matter: does the “stick” model hold? |
1Center for Biomedical Imaging, NYU School of Medicine, New York, NY, United States, 2CUBRIC, Cardiff University, Cardiff, United Kingdom |
| 1095
|
13:15
|
Mean lung alveolar dimension mapping with hyperpolarized 3He and 129Xe diffusion-weighted MRI |
1Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom |
| 1096 | 13:15
|
A compartment based model for non-invasive cell body imaging by diffusion MRI |
1Computer Science Department and Centre for Medical Imaging Computing, University College London, London, United Kingdom, 2Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal |
| 1097 | 13:15
|
GPU-based Monte-Carlo simulation of diffusion in astrocytes reconstructed from confocal microscopy |
1Molecular Imaging Research Center (MIRCen), Commissariat à l'Energie Atomique, Fontenay-aux-Roses, France, Fontenay aux Roses, France |
| 1098 | 13:15
|
What is the feasibility of estimating axonal conduction velocity from in vivo microstructural MRI? |
1CUBRIC, Cardiff University, Cardiff, United Kingdom |
| 1099 | 13:15
|
Measurement of Intra-Axonal Water Diffusivity in Normal Human White Matter |
1Clinic for Radiology, Medical Physics, Faculty of Medicine, Medical Center - University of Freiburg, Germany, Freiburg, Germany |
| 1100 | 13:15
|
Accurate Estimation of Microscopic Diffusion Anisotropy Using Multi-shell Double Diffusion Encoding |
1Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal, 2Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 3Center of Functionally Integrative Neuroscience (CFIN), Aarhus University, Aarhus, Denmark, 4Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark |
| 1101 | 13:15
|
From physical chemistry to human brain biology: unconstrained inversion of 5-dimensional diffusion-T2 correlation data |
1CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 2Physical Chemistry, Department of Chemistry, Lund University, Lund, Sweden, 3Random Walk Imaging AB, Lund, Sweden, 4Clinical sciences, Lund, Lund University, Lund, Sweden, 5Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States |
| 1102 | 13:15
|
Echo Time Dependence of Double Diffusion Encoding Measurements of Microscopic Diffusion Anisotropy |
1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States |
| 1103 | 13:15
|
Validity extension of stimulated echoes to imaginary signals arising for double diffusion encoding of closed pores |
1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany |
| 1104 | 13:15
|
Measurement of diffusion exchange in yeast with Diffusion Exchange Spectroscopy (DEXSY) |
1Centre for Advanced Biomedical Imaging, Division of Medicine, UCL, London, United Kingdom, 2The Francis Crick Institute, London, United Kingdom, 3Centre for Medical Imaging Computing, Department of Computer Science, UCL, London, United Kingdom |
| 1105 | 13:15
|
Differences between treated glioblastoma and metastatic brain neoplasms revealed by non-Gaussian diffusion MRI and 18F-FET-PET |
1Institute of Neuroscience and Medicine 4, Research Centre Juelich, Juelich, Germany, 2Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, 3Center of Integrated Oncology (CIO), Universities of Cologne and Bonn, Cologne, Germany, 4JARA - BRAIN - Translational Medicine, RWTH Aachen University, Aachen, Germany |
| 1106 | 13:15
|
Simulation of diffusion in axons with harmonic and stochastic trajectories |
1Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden, 2Random Walk Imaging, Lund, Sweden |
| Power Pitch Theater B - Exhibition Hall | Thursday 13:15 - 14:15 | Moderators: Alexandra PETIET & Yen-Yu Ian Shih | (no CME credit) |
| 1107
|
13:15
|
Functional MRI mapping the optogenetic activation of the lateral hypothalamus driven by an MRI-guided robotic arm (MgRA) |
1Research Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Graduate Training Centre of Neuroscience, University of Tuebingen, Tuebingen, Germany, 3The Max Planck Institute for the Science of Light, Erlangen, Germany, 4The Werner Reichardt Centre for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany |
| 1108 | 13:15
|
Multi-centre resting-state fMRI comparison reveals common functional networks in the mouse brain. |
1Singapore Bioimaging Consoritum, Agency for Science, Technology and Research, Singapre, Singapore, 2Istituto Italiano di Tecnologia, Center for Neuroscience and Cognitive Systems @ UNITN, Rovereto, Italy, 3Center for Mind/Brain Sciences, University of Trento, Rovereto, Italy, 4Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium, 5Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada, 6Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany, 7Department of Radiology, University of Freiburg, Freiburg, Germany, 8Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, 9Queensland Brain Institute, The University of Queensland, Brisbane, Australia, 10Max Planck University College London Centre for Computational Psychiatry and Ageing Research, University College London, London, United Kingdom, 11Departments of Psychiatry and Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada, 12Department of Biophysics and Nuclear Medicine, University Hospital Strasbourg, Strasbourg, France, 13Institute for Biomedical Engineering, University and ETH Zürich, Zürich, Switzerland, 14Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland, 15Institute of Automation, Chinese Academy of Sciences, Beijing, China, 16School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China, 17Department of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland |
| 1109
|
13:15
|
Brain-wide functional organization of the hippocampus along the dorsoventral axis: an optogenetic fMRI study |
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China, 3Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States |
| 1110
|
13:15
|
Simultaneous fMRI and Fast-Scan Cyclic Voltammetry: Methodological Considerations and In Vivo Oxygen Measurements |
1Biomedical Research Imaging Center and Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States |
| 1111 | 13:15
|
Neural activity pattern(s) underlying brain interhemispheric propagation: An optogenetic fMRI study |
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China |
| 1112 | 13:15
|
Dynamic Autoregulation in Pharmacological Mouse fMRI Revisited: Abrupt Changes in Systemic Blood Pressure Elicit Significant BOLD Effects in the Murine Brain |
1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany, 2Max Delbrueck Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany, 3Institute of Vegetative Physiology, Charité – University Medicine, Berlin, Germany, 4DZHK (German Centre for Cardiovascular Research), Berlin, Germany, 5Department of Endocrinology, Charité – University Medicine, Berlin, Germany, 6Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany |
| 1113 | 13:15
|
Focused ultrasound-mediated disruption of the blood-brain barrier for targeted delivery of neurotransmitters to the rat brain |
1Brigham and Women's Hospital, Boston, MA, United States, 2Boston Children's Hospital, Boston, MA, United States, 3Harvard Medical School, Boston, MA, United States |
| 1114 | 13:15
|
Simultaneous fMRI and multispectral fiber-photometry for concurrent triple-modality measurement of genetically encoded calcium activity, CBV and BOLD |
1Biomedical Research Imaging Center and Department of Neurology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2Neurobiology Laboratory, National Institute of Environmental Health Sciences, NIH, RTP, NC, United States |
| 1115 | 13:15
|
CBV fMRI study of the olfactory and visual processing in same mice |
1Merck & Co., Inc., West Point, PA, United States, 2Merck & Co., Inc., Rahway, NJ, United States, 3Merck & Co., Inc., South San Francisco, CA, United States, 4Merck & Co., Inc., Boston, MA, United States |
| 1116 | 13:15
|
Distinct structure-function relationships at different hierarchical levels of structural connectivity in the rat brain. |
1Biomedical MR Imaging and Spectroscopy group, Center for Image Sciences, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands, 2Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands, 3Department of Anatomy, University of Rostock, Rostock, Germany, 4Department of Pediatric Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands |
| 1117
|
13:15
|
Functional connectivity under six anesthesia protocols and the awake condition in rat brain |
1A.I.V. Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, 2Department of Radiology, Oulu University Hospital, Oulu, Finland |
| 1118 | 13:15
|
Quasiperiodic Patterns in BOLD fMRI Reflect Neuromodulatory Input |
1Neuroscience, Emory University, Atlanta, GA, United States, 2Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, United States |
| 1119 | 13:15
|
Validation of spinal cord fMRI with LFP and spike activity in non-human primates |
1Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 2Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 3Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States |
| 1120 | 13:15
|
Diffusion fMRI reveals thalamo-cortical circuitry using forepaw stimulation in rats |
1Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, 2Department of Computer Science, Centre for Medical Image Computing, London, United Kingdom |
| 1121 | 13:15
|
Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI |
1Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 2Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, United States, 3Quantitative Neuroscience with Magnetic Resonance (QNMR) Core Center, Yale University, New Haven, CT, United States, 4Neuroscience, Yale University, New Haven, CT, United States, 5The John B. Pierce Laboratory, Yale University, New Haven, CT, United States, 6Biomedical Engineering, Yale University, New Haven, CT, United States |
Organizers: Richard Buxton, Hanzhang Lu, Benedikt Poser
| N01 | Thursday 13:15 - 15:15 | Moderators: Hanzhang Lu & Richard Buxton |
13:15
|
Dynamic Functional Connectivity Methods | |
1University of California, San Diego, United States |
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This educational talk will review methods for the assessment of dynamic functional brain connectivity. |
13:45
|
Mechanisms & Clinical Applications of Dynamic Functional Connectivity | |
1MIALab, 2The Mind Research Network, Albuquerque, NM, United States |
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Dynamic functional network connectivity is a promising technique for clinical applications. It has been successfully applied in the analysis of neurological illnesses and as a source of classification features to separate patients from controls. Advantages and pitfalls of dynamic analysis is discussed and compared to it’s to static connectivity alternative. The two flavors of functional connectivity offer complementary information depending on the specific application. This is exemplified discussing the results obtained from schizophrenia, Huntington’s disease, traumatic brain injury and substance addiction. |
| 1122 | 14:15
|
Voxel-wise mapping of spontaneous brain network dynamics in the mouse brain |
1Neural Computation Laboratory, Istituto Italiano di Tecnologia, CNCS@UNITN, Rovereto, Italy, 2CIMEC, University of Trento, Rovereto, Italy, 3Functional Neuroimaging Laboratory, Istituto Italiano di Tecnologia, CNCS@UNITN, Rovereto, Italy |
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Resting-state fMRI has been widely used to map brain network dynamics via sliding-window correlations between regional functional signals. Using frame-wise clustering of spontaneous BOLD fMRI, here we map the dynamics of brain-wide network activity in the mouse brain with voxel-resolution, at the subject and group level, without the need to use pre-imposed regional parcellation or correlation windows. This approach revealed a reproducible set of recurrent brain states encompassing previously defined functional connectivity networks, which happen at specific phases of global fMRI signal oscillations. Our results provide a novel interpretative framework for the emergence and organization of brain-wide network dynamics. |
| 1123 | 14:27
|
Whole brain Quasi-Periodic patterns interact with visual stimulation processing in mice |
1University of Antwerp, Antwerpen, Belgium, 2Emory university, Atlanta, GA, United States |
||
We show the detection of whole-brain mouse Quasi-periodic patterns (QPPs), highlighting their interaction with the global signal and coincidence with anti-correlation between speculative mouse Default Mode (DMN) and Task-Positive (TPN)-like networks. We further investigated how QPPs interact with sensory information processing. By tracking QPP behavior during an fMRI visual stimulation block design, we illustrate how QPPs can become modulated by visual stimulation, triggering or diminishing their occurrence. We then linearly regressed QPPs from the fMRI images to show how QPPs underlie a substantial fraction of visual response magnitude and variance. These results suggest the relevance of QPPs in sensory processing. |
| 1124 | 14:39
|
Quantitative deconvolution of neuronal-related BOLD events with Multi-Echo Sparse Free Paradigm Mapping |
1Section on Functional Imaging Methods, National Institute of Mental Health, Bethesda, MD, United States, 2Basque Center on Cognition, Brain and Language, San Sebastian, Spain, 3FMRI Core, National Institute of Mental Health, Bethesda, MD, United States |
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This work proposes a novel formulation of the Sparse Free Paradigm Mapping (SPFM) algorithm for Multi-Echo (ME) fMRI that produces estimates of ΔR2* with interpretable units (s-1) without prior timing information of task events. Here we show how ΔR2* time-series estimated with ME-SPFM have physiologically plausible values, in agreement with previously published estimates of ΔR2* for neuronal events. We also show, how having easily interpretable units permits detection of artefactual events that can be easily removed from subsequent analysis and interpretation. Our results suggest that ME-SPFM may provide a pseudo-quantitative method to study the time-varying nature of brain activity in experimentally unconstrained paradigms (naturalistic, resting-state) or clinical applications (detection of inter-ictal epileptic events). |
| 1125 | 14:51
|
Efficacy of different dynamic functional connectivity methods to capture cognitively relevant information |
1Department of Electrical & Computer Engineering, Texas Tech University, Lubbock, TX, United States, 2Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States, 3FMRI Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States |
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With a multitask dataset (rest, memory, video, and math) serving as ground truth, we evaluated the efficacy of four different methods of estimating dynamic functional connectivity (dFC)—namely sliding window correlation (SWC), sliding window correlation with L1-regularization (SWC_L1), dynamic conditional correlation (DCC), and multiplication of temporal derivatives (MTD)—to capture cognitively relevant information. We used dFC estimates of each method as inputs for k-means, and evaluated how well they segregate scan periods for different tasks. We found that moving average DCC produces best results, especially for short window length (WL ≤ 9sec), suggesting DCC may more reliably reveal dFC linked to mental states. |
| 1126 | 15:03
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EEG microstate and spectral signatures of epileptic patterns found in fMRI dynamic functional connectivity |
1ISR-Lisboa/LARSyS and Department of Bioengineering, Instituto Superior Técnico, Lisboa, Portugal, 2Department of Neurophysiology, Centro Hospitalar Psiquiátrico de Lisboa, Lisboa, Portugal |
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We aimed to investigate EEG signatures specifically associated with epileptic patterns of dynamic functional connectivity (dFC) found in BOLD-fMRI data. We estimated dFC using a sliding-window correlation analysis and applied dictionary learning (DL) to identify the most prominent patterns while forcing a certain degree of sparsity in time. Upon the labelling of each time window based on the pattern exhibiting the highest contribution, we investigated pattern-specific microstates (MS) and spectral proprieties in simultaneously recorded EEG data. In contrast with the spectral proprieties, EEG MS revealed robust signatures of epileptic dFC patterns in all patients. |
15:15
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Adjournment & Meet the Teachers |
| N03 | Thursday 13:15 - 15:15 | Moderators: Huijun Chen & Joseph Hajnal |
| 1127
|
13:15
|
On the Point of Gradient Moment Expansion for Multi-Spoke RF Pulses |
1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany |
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In this work we investigated the influence of the point of gradient moment expansion (texp) for multi-spoke RF pulses. The results demonstrate that texp=tISO is ideal if no flow in the RO direction is present, but severe displacement artifacts occur if this is the case. texp=TE induces shifts that are directed along the vessel orientation and are independent of the encoding orientation. The presented techniques are the basis for correct velocity quantification with controlled displacement for multi-spoke RF pulses allowing in-plane B1+ homogenization using parallel transmission at UHF. |
| 1128 | 13:27
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Design of universal parallel-transmit refocusing kT-point pulses and application to 3D T2-weighted imaging at 7T |
1DRF/Joliot/Neurospin, CEA, Gif sur Yvette, France, 2Siemens Healthcare, Saint Denis, France, 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany |
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The kT-point technique exploits the dynamic RF shimming capability of parallel transmission to uniformly excite the spins. That technique allows homogenizing the flip angle in RF-spoiled sequences but also the rotation angle in sequences involving non-selective refocusing pulses. As far as the flip angle is concerned, it has been shown that so-called universal kT-point pulses can be designed to work robustly on any subject without having to tailor the pulse to the subject. In this study we propose to extend the universality concept to refocusing pulses, and to give an experimental demonstration with 3D fast spin echo brain imaging. |
| 1129
|
13:39
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Improving FLAIR SAR efficiency by predicting B1-maps at 7T from a standard localizer scan using deep convolutional neural networks |
1Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, 2Siemens Healthcare Pty Ltd., Brisbane, Australia |
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Ultra-high-field (7T) instrumentation offers the possibility of acquiring FLAIR images at an improved resolution when challenges such as efficient B1 calibration and SAR reductions can be realized. Instead of acquiring a separate B1-map, we propose to predict B1-maps based on the implicit B1 inhomogeneity field present in an AutoAlign localizer using deep convolutional neural networks. We show that a 34% reduction in SAR can be achieved by adjusting the power of FLAIR's adiabatic inversion pulse on a slice-by-slice basis using the B1 information without degradation of image quality. |
| 1130 | 13:51
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In-vitro demonstration of explicit temperature control using pTx and temperature virtual observation points at 7T |
1NeuroSpin, CEA, Saclay, France, 2CMRR, University of Minnesota, Minneapolis, MN, United States |
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Recent numerical studies have shown that temperature could be controlled explicitly at the pulse design stage in parallel transmission, furthermore reporting that further scan performance could be gained if the more relevant safety metric that is temperature, instead of the specific absorption rate, was controlled. Bioheat models yet are still undergoing experimental validations. So as a first step, this work reports an experimental demonstration of flip-angle homogenization with temperature control on a water phantom with parallel transmission at 7T. |
| 1131 | 14:03
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Slab-Selective Spectral and Spectral-Spatial Prewinding RF Pulses |
1Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, 2Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, United States |
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We introduce a new type of small-tip angle prewinding RF pulse that compensates for spin dephasing attributed to off-resonance and is also slab-selective, which can help limit the volume of coverage. We design purely spectral slab-selective pulses that prewind a limited global off-resonance bandwidth, and spectral-spatial slab-selective pulses that adapt the prewinding bandwidth spatially. We demonstrate these pulse designs in simulation and in experiments using a gel phantom with a distorted field and a volunteer’s brain. Both pulses create sharp slab profiles, while the spectral-spatial pulse outperforms in terms of target magnetization phase. |
| 1132 | 14:15
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Magnetization Transfer effects in Actual Flip angle Imaging |
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom |
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The AFI sequence is a robust flip angle mapping method and is used within quantitative MRI protocols. AFI is a modified spoiled gradient echo (SPGR) sequence, employing interleaved TR times of different lengths. It is well known that SPGR signal behaviour is sensitive to Magnetization Transfer effects, so in this work we used a two-pool model to derive signal equations for AFI that include MT. We found that MT will lead to an underestimation of flip angle by up to 6% in white matter and that longer TR and lower RF energy lead to larger bias. |
| 1133 | 14:27
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The travelling pulses: multicenter evaluation of universal pulses at 7T |
1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2NeuroSpin, CEA, Saclay, France, 3Siemens Healthcare, Saint-Denis, France, 4German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany |
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It has been shown recently that parallel transmission universal pulses (UPs), optimized offline on a training field-maps database, can be used to robustly mitigate B1+ inhomogeneity on other subjects, thus holding great potential for spreading their utility by sparing the user the time-consuming individualized calibration. For these UPs to be used widely, however their performance needs to be immune to inter-site differences. In this study, we examined the robustness of the UPs against inter-site variability. Our results so far obtained at two sites show that the UPs are quite robust in producing uniform contrast across the brain despite these differences. |
| 1134 | 14:39
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In vivo Simultaneous Measurement of δf, T1, T2, and T2* by Magnetic Resonance Fingerprinting with Quadratic RF Phase |
1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Radiology, Case Western Reserve University, Cleveland, OH, United States |
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We propose a novel Magnetic Resonance Fingerprinting pulse sequence with quadratic RF excitation phase (qRF-MRF) for the purpose of simultaneous measurement of T2* in addition to previously established spin parameters δf, T1, and T2. The original bSSFP based MRF pulse sequence1 was modified to incorporate excitation segments with quadratic RF phase to sensitize signal evolutions to T2*. Measurements using qRF-MRF were performed in both phantom and in vivo. Maps from qRF-MRF were validated against bSSFP based MRF and Multi-GRE. |
| 1135 | 14:51
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Cortical T1 mapping with 3D MR Fingerprinting at 7T using a single transmit channel |
1Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Department of Radiology, New York University School of Medicine, Center for Advanced Imaging Innovation and Research (CAI2R) and Bernard and Irene Schwartz Center for Biomedical Imaging, New York, NY, United States, 3Siemens Healthcare K.K., Tokyo, Japan |
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A prototype 3D MRF sequence was evaluated for cortical T1 mapping at 7T in the context of the Human Connectome Project (HCP). Phantom results showed that the 3D MRF T1 map of a liquid was in good agreement with gold standard IR-SE measurements. The synthetic MPRAGE and synthetic T2-SPACE created from the 3D MRF data performed well in HCP pipeline. The cortical thickness estimation was fairly stable across different imaging resolutions. The R1 of the cortex showed higher value than expected, which may indicate that more advanced signal models may be necessary to accurately describe the spin dynamics in-vivo. |
| 1136 | 15:03
|
Pulseq-GPI: A single, comprehensive framework for MR method development |
1Medical Imaging Research Center, MIRC, Dayananda Sagar Institutions, Bengaluru, India, 2Wipro GE Healthcare Pvt Ltd, Bengaluru, India, 3New York University Tandon School of Engineering, New York, NY, United States, 4Dept of Radiology, Medical Physics, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, Freiburg, Germany, 5Functional MRI Laboratory, University of Michigan, Michigan, MI, United States, 6Dept. of Radiology, Columbia University Medical Center, New York, NY., Columbia, SC, United States |
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This work develops and integrates an open source implementation of the |
| S02 | Thursday 13:15 - 15:15 | Moderators: Nivedita Agarwal & Shigeki Aoki |
| 1137 | 13:15
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Imaging Brain Clearance in the Mouse Brain: Aquaporin-4 Modulates Glymphatic Inflow |
1Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom |
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The ‘glymphatic’ system, which has recently been identified using MRI, is a brain-wide pathway for removal of waste solutes. This system is implicated in Alzheimer’s disease (AD), due to discovery that both amyloid-β and tau, accumulations that define AD, are cleared from the brain via this pathway. Using contrast-enhanced MRI, we demonstrate that glymphatic function is dependent upon aquaporin-4, a water channel located on astrocytic endfeet surrounding blood vessels in the brain. Herein, using a novel pharmacological approach, we show that aquaporin-4 represents a suitable drug target for manipulation of glymphatic function in the brain, and in treatment of AD. |
| 1138 | 13:27
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PC-MRI measurements of net CSF flow through the cerebral aqueduct strongly depend on respiration |
1Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Spinoza Center for Neuroimaging, Amsterdam, Netherlands |
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In this work the influence of respiration on net CSF flow measurements was investigated. In 12 volunteers net CSF flow was measured in the cerebral aqueduct using PC-MRI at 7T, with respiratory gating on expiration and on inspiration, and without respiratory gating. Repeated measurements were performed. Net flow over the cardiac cycle was determined. Net CSF flow (mean±sd) was -0.64±0.32 mL/min (caudal) during expiration, +0.12±0.49 mL/min (cranial) during inspiration, and -0.31±0.18 mL/min without respiratory gating. Two outliers, with reversed (cranial) net CSF flow, were observed when no respiratory gating was performed. Repeatability was best for gating on inspiration. |
| 1139 | 13:39
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Cine MRI assessment of carotid artery pulse wave velocity and reflected wave amplitude in children with sickle cell disease |
1SickKids Hospital, Toronto, ON, Canada, 2University of Toronto, Toronto, ON, Canada |
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The mechanical and morphological properties of the cerebral vasculature can be studied by measuring blood flow dynamics of the feeding arteries. In this study, we used high resolution phase contrast MRI to measure the blood flow and vessel area of the common carotid arteries of children with and without sickle cell disease (SCD). Preliminary results show that pulse wave velocity and wave reflection is significantly higher in patients with SCD, suggesting increased vessel stiffness and downstream abnormalities in the vasculature. This method is clinically feasible and may provide useful insight into the vascular properties of children with cerebrovascular disease. |
| 1140 | 13:51
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Optic Nerve Sheath Volume Changes Acutely in Response to Intracranial Pressure Change after Lumbar Puncture and CSF Drainage |
1Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States |
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This study used 3D, T2W imaging of the brain to evaluate the optic nerve sheath (ONS) in 10 patients with idiopathic intracranial hypertension (IIH). Patients were imaged pre- and immediately post-lumbar puncture/CSF drainage. Images were reformatted to be perpendicular to the optic nerve and the volume of the ONS pre- and post-lumbar puncture was calculated. The study found that ONS volume decreased significantly within an 82 minute window in response to a reduction in CSF pressure, and this change can be quantitatively evaluated using MRI. |
| 1141 | 14:03
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Association between Gray Matter alterations and CSF biomarkers in amnestic MCI patients |
1Center for Mind/Brain Sciences-University of Trento, Trento, Italy, 2Department of Psychology and Cognitive Science-University of Trento, Trento, Italy, 3IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy, 4Service of Statistics, IRCCS Fatebenefratelli, Brescia, Italy, 5IRCCS, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy, 6Department of Physiology and Pharmacology, University of Rome, Rome, Italy, 7Sapienza University of Rome, Rome, Italy, 8Aix-Marseille Universitè, Marseille, France, 9Alzheimer’s Disease Unit and Other Cognitive Disorders Unit, Hospital Clinic de Barcelona, Barcelona, Spain, 10University of Genoa, Genoa, Italy, 11Lab of Clinical Neurochemistry, University of Perugia, Perugia, Italy, 12INSERM, Imagerie Cerebrale et Handicaps Neurologiques, Toulouse, France, 13Catholic University, Policlinico Gemelli, Rome, Italy, 14University of Leipzig, Leipzig, Germany, 15Fondazione SDN per la Ricerca e l’Alta Formazione in Diagnostica Nucleare, Naples, Italy, 16Aristotle University of Thessaloniki, Thessaloniki, Greece, 17Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, Netherlands, 18VU University Medical Center, Amsterdam, Netherlands, 19University Medical Center, Goettingen, Georg-August-University, Goettingen, Germany, 20Service de Pharmacologie-Hôpital Huriez-CHRU, Lille, France, 21GSK, Neurosciences Therapeutic Area, Brentford, United Kingdom, 22Mediterranean Institute of Cognitive Neurosciences, Marseille, France, 23Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland, 24Laboratory of Alzheimer’s Neuroimaging and Epidemiology - LANE, IRCCS Institute - The Saint John of God Clinical Research Centre, Brescia, Italy |
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In this study the association between CSF and structural imaging based early biomarker of Alzheimer Diasease (AD) was investigated in amnestic Mild Cognitive Impairment (aMCI) patients. Voxel based morphometry and partial least square correlation were used to analyze differences in local and whole brain GM profiles (covariance) between two groups of aMCI patients divided in two groups based on CSF amyloid (Aβ42) levels. Both voxel-wise and structural covariance GM differentiated Aβ positive (prodromal AD) from Aβ negative patients. These results indicate that GM measures may provide a sensitive metric for tracking AD progression. |
| 1142 | 14:15
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2D phase contrast MRI to quantify CSF dynamics change after surgery of Chiari “malformations" |
1imaging processing, university hospital, Amiens, France, 2neurosurgery, university hospital, Amiens, France, 3radiology, university hospital, Amiens, France |
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Diagnosis of Chiari malformation (CM) is mainly based on morphological. The objective of this study was to quantify the evolution of CSF and blood flows dynamics before and after surgery treatment of CM. 21 patients who underwent surgery for CM, and presented good clinical outcome at 12 months were retrospectively included. We have shown that in CM, CSF flow is mainly reduced at the foramen magnum whereas it is normal at the cervical level. CM reduces jugular outflow. Complementary to the morphological investigation 2D PCMRI should be take in account to improve the evaluation of the severity of the Chiari Malformation. |
| 1143 | 14:27
|
Quantitative Modeling of Glymphatic Pathways of the Brain Using MRI |
1Neurology, henry ford health system, detroit, MI, United States, 2Neurology, Wayne State University, detroit, MI, United States, 3Physics, Oakland University, Rochester, MI, United States |
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The dynamic exchange of CSF with ISF is identified as the glymphatic system. The impairment of the glymphatic clearance is involved in the development of neurodegenerative conditions. Despite many recent studies that investigated the glymphatic system, few studies have tried to use a mathematical model to describe this system, quantitatively. In this study, we aim to model the glymphatic system from the kinetics of GD-DTPA tracer in order to 1) map the glymphatic system pathways, 2) derive kinetic parameters of the glymphatic system, and 3) provide quantitative maps of the structure and function of this system. |
| 1144 | 14:39
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Phase-contrast MRI for estimating global cerebral blood flow of mice at 11.7T: optimization and age-dependence |
1Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, 3Department of Electronic Science, Xiamen University, Xiamen, Fujian, China, 4Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States |
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Cerebral blood flow (CBF) is a crucial physiological parameter reflective of brain functioning and metabolism. In this study, our goal was to systematically optimize a phase-contrast (PC) quantitative flow technique for CBF assessment in mice. We also demonstrated the sensitivity of this technique to longitudinal CBF changes in aging. This optimized PC protocol may serve as a helpful non-invasive tool for CBF measurement in preclinical studies of brain physiology and pathophysiology with mouse disease models. |
| 1145 | 14:51
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Impact of the glymphatic system on the kinetic and distribution of gadodiamide in the rat brain: Observation by dynamic MRI and effect of circadian rhythm on tissue gadolinium concentrations. |
1Nagoya University, Nagoya, Japan, 2MR&CT Contrast Media Research, Bayer AG, Berlin, Germany |
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We tried to elucidate the role of the glymphatic system on the distribution and kinetics of a linear gadolinium based contrast agent in the rat brain. Dynamic MRI signal changes of the brain and the cerebrospinal fluid (CSF) indicated that intravenously administrated gadodiamide enter from blood into the CSF, indicating the involvement of the glymphatic system. The long term presence of gadolinium in the brain after repeated administration of gadodiamide quantified by ICP-MS indicates the involvement of the glymphatic system on the clearance of gadolinium from brain tissue in terms of the influence of circadian rhythm and anesthesia during administration. |
| 1146 | 15:03
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Increased pulsatility in cerebral perforating arteries in patients with lacunar infarction or deep intracerebral hemorrhage, an explorative 7T MRI study |
1Radiology, UMCU, Utrecht, Netherlands, 2Brain Center Rudolf Magnus, UMCU, Utrecht, Netherlands, 3Department of Neurology, Radboud University Medical Center, Nijmegen, Netherlands |
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Cerebral small vessel disease is a major cause of dementia and stroke with unknown pathophysiology. Increased blood flow pulsation is hypothesized to be an underlying pathology of small vessel disease, but has not been investigated in cerebral small vessels. Using 2D phase contrast MRI at 7T, we measured the pulsatility index in cerebral perforating arteries of patients with lacunar infarction or deep intracerebral haemorrhage and a group of healthy controls. We showed that both patient groups have a higher pulsatility index in small vessels than controls. This warrants further research into the possible role of pulsatility in small vessel disease. |
| S03 | Thursday 13:15 - 15:15 | Moderators: Ovidiu Andronesi & Hermien Kan |
| 1147 | 13:15
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Correlating Proteoglycan Concentration in Intervertebral Discs Using 1H MR Spectroscopy with Lumber Lordotic Angle |
1Radiological Science, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom, 2Clinical Imaging Sciences Centre, Brighton Sussex Medical School, Brighton, United Kingdom, 3Computing, Engineering and Mathematics, University of Brighton, Brighton, United Kingdom |
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Both proteoglycan (PG) concentration and lumbar lordotic (LL) angle are linked with the health of spinal discs. Previously, it has been shown that PG concentration can reliably be measured using 1H MR Spectroscopy at 1.5T and that PG concentration is higher in female discs compared with male discs. This study has now been extended to show a correlation between PG and LL angle in a group of female participants. |
| 1148 | 13:27
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31P NMRS-determined intramuscular Mg2+ and its relation to quantitative NMR imaging and spectroscopy outcome measures in Duchenne muscular dystrophy |
1NMR Laboratory, Institute of Myology, Paris, France, 2NMR Laboratory, CEA, DRF, IBFJ, MIRCen, Paris, France |
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Free [Mg2+] determination with 31P NMRS is highly dependent on a precise knowledge of intracellular pH. The pH of Duchenne muscular dystrophy patients as determined by the 31P NMRS chemical shift of inorganic phosphate is abnormally alkaline. We have recently shown that intracellular pH in skeletal muscle could be determined using 1H NMRS of carnosine and that intracellular pH was alkaline in a proportion but not in all the DMD patients with a 31P NMRS-based alkaline pH. We decided to take advantage of this 1H NMRS-based intracellular determination to determine whether free intramuscular [Mg2+] is, in fact, abnormally low in DMD patients and investigate its relation with water T2 and fat fraction. |
| 1149
|
13:39
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Carnitine supplementation improves skeletal muscle acetylcarnitine formation and metabolic flexibility |
1Department of Radiology & Nuclear Medicine, Maastricht University Medical Center +, Maastricht, Netherlands, 2Department of Human Biology & Human Movement Sciences, Maastricht University Medical Center +, Maastricht, Netherlands, 3Department of Internal Medicine, Division of Endocrinology, Maastricht University Medical Center +, Maastricht, Netherlands |
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The formation of acetylcarnitine may serve as a mitochondrial rescue mechanism to prevent the development of metabolic inflexibility and type 2 diabetes. We here used a novel magnetic resonance spectroscopy protocol, using long echo times, to determine acetylcarnitine concentrations in skeletal muscle in vivo. Carnitine supplementation enhanced the increase in acetylcarnitine concentration in resting muscle over the day as well as the capacity to form acetylcarnitine with exercise. Furthermore, carnitine supplementation completely restored metabolic flexibility suggesting that carnitine supplementation may be an interesting aid in improving disturbed metabolism in subjects prone to develop type 2 diabetes mellitus. |
| 1150 | 13:51
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Why does a transient NAD+ infusion lead to a sustained increase in brain ATP levels? - A dynamic 31P MRS-MT imaging investigation at ultrahigh field |
1Center of Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, United States |
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It has been observed recently that transient intraperitoneal infusion of oxidized nicotinamide adenine dinucleotide (NAD+) can increase intracellular ATP levels in healthy rat brain over time. Intrigued by this fascinating phenomenon, we investigated the dynamic changes of major phosphorous metabolites and the kinetics and metabolic rates of the ATP synthesis reactions in rat brain before and after introducing exogenous NAD+ using combined in vivo 31P MR spectroscopy (MRS) imaging with magnetization transfer (MT) technique at 16.4 Tesla magnet. The results of this comprehensive study provide important information for elucidating the cerebral energetic mechanism and regulation underlying this phenomenon. |
| 1151
|
14:03
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Early MRS biomarkers accurately predict neurodevelopment after neonatal encephalopathy in a multicentre setting |
1Centre for Perinatal Neuroscience, Imperial College London, London, United Kingdom, 2Imperial College Healthcare NHS Trust, London, United Kingdom, 3Medical Physics and Bioengineering, University College London Hospitals NHS Trust, London, United Kingdom, 4Medway NHS Foundation Trust, Kent, United Kingdom, 5Department of Neonatology, Children's Hospital of Michigan, Detroit, MI, United States |
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In neuroprotection trials for neonatal encephalopathy, the typical clinical outcome measures can only be measured reliably after a period of years. In a multicentre study covering eight sites and recruiting 224 infants, we demonstrate that MRS measures made within two weeks of birth provide quantitative and objective tools for predicting neurodevelopmental abnormalities usually only observed years after the initial injury. In particular, the thalamic concentration of tNAA (N-acetyl aspartate + N-acetyl aspartyl glutamate) has an area under the receiver operating characteristic curve of 0.99 (95%CI 0.98–1.00, n=82). Such tools could greatly speed up the next generation of clinical trials. |
| 1152 | 14:15
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Probing the Excitatory-Inhibitory Balance in Humans during Probabilistic Learning |
1Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel, 2Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel |
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The dorsal anterior cingulate cortex (dACC) is crucial for reinforcement learning and decision-making. However, the excitatory and inhibitory mechanisms underlying these functions, governed by glutamate and GABA, are not properly understood. We used 1H-MRS to probe glutamate and GABA in the dACC during a task comprised of three conditions: discrimination, uncertainty and a null condition. A preference to higher gain option during the discrimination condition was reflected by elevated GABA levels during the uncertainty condition compared to the discrimination condition. Elevated GABA levels during the null condition predicted better behavioral-acquisition. These results indicate dACC involvement during learning of high load cognitive situation. |
| 1153 | 14:27
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Investigation of Anterior Cingulate Cortex γ-Aminobutyric Acid and Glutamate-Glutamine Levels in Patients with Obsessive-Compulsive Disorder by Proton Magnetic Resonance Spectroscopy |
1Department of Radiology, Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai, China, 2Department of Functional Neurosurgery, Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai, China, 3Philips Healthcare, Shanghai, China, 4Philips Healthcare, Cleveland, OH, United States, 5Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States |
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The aim of this study is to evaluate the feasibility of 1H-MR edited spectroscopy for the detection of cerebral abnormalities in Obsessive-Compulsive Disorder (OCD) patients. Twenty-three OCD patients and Twenty-four normal controls (NC) underwent MRS. The γ-Aminobutyric Acid (GABA) and Glutamate-Glutamine (Glx) level of anterior cingulate cortex (ACC) was quantified based on the GANNET 2.0 software. Differences of GABA and Glx levels between two groups were analyzed using independent two sample t-test analysis. Relative to NC group, OCD patients had higher GABA concentration in the ACC (p<0.05), but had no significant difference in ACC Glx levels. To our knowledge, this study presents the first GABA concentration measurements within ACC in OCD patients. Our results suggested that GABA and Glx levels in the ACC might be promising diagnostic and monitoring biomarker for OCD. |
| 1154
|
14:39
|
Increased spatial resolution of MR Spectroscopic Imaging improves the detectability of metabolic changes in Multiple Sclerosis lesions |
1High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 3Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MA, United States, 5Department of Neurology, Medical University of Vienna, Vienna, Austria, 6Christian Doppler Laboratory for Clinical Molecular Molecular MR Imaging, Vienna, Austria |
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MR Spectroscopic Imaging provides the ability to assess the abundance and spatial distribution of several neurometabolites, which are characteristic for pathophysiological processes related to the formation and development of Multiple Sclerosis lesions. In presented work we aimed to compare the detectability of metabolic changes in MS lesions for three different in-plane resolutions of MRSI, i.e. 2.2×2.2 mm2, 3.4×3.4 mm2 and 6.8×6.8 mm2. Our results suggest that the vast majority of metabolic changes in MS cannot be reliably assessed using MRSI with typical matrix sizes of 24x24 to 32x32. With ultra-high spatial resolution (2.2x2.2 mm2 in-plane) even very small MS lesions can be well resolved. |
| 1155
|
14:51
|
A Feasibility Study of Radiation Therapy Dose Escalation Guided by Spectroscopic Magnetic Resonance Imaging in Patients with Glioblastoma |
1Department of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, United States, 2Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 3Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, United States, 4Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, United States, 5Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, 6Department of Radiation Oncology, The Johns Hopkins University, Baltimore, MD, United States, 7Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, United States |
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Glioblastoma (GBM) is a grade IV primary brain tumor with poor outcomes despite surgical resection, chemotherapy, and radiation. Often, disease will recur in regions in the penumbra of the treatment volume, hypothesized to occur because anatomic MRI does not fully capture neoplastic infiltration. Spectroscopic magnetic resonance imaging (sMRI) enables in vivo whole-brain analysis of metabolic activity, and has been shown to sensitively and specifically identify regions of non-enhancing, infiltrating tumor. We present an ongoing prospective clinical study to target metabolically active tumor identified by sMRI for a radiation boost, with the aim of improving outcome in patients with GBM. |
| 1156 | 15:03
|
Predictive Value of Magnetic Resonance Spectroscopic Imaging during Anti-angiogenic Treatment in Recurrent Glioblastoma |
1Radiology, Massachusetts General Hospital, Boston, MA, United States, 2Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 3Neurology, Massachusetts General Hospital, Boston, MA, United States, 4Radiology, Boston Children's Hospital, Boston, MA, United States |
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Our study examines the use of MR Spectroscopic Imaging to predict treatment response to anti-angiogenic therapy for recurrent glioblastoma patients. Our data demonstrated that early changes at 1-3 days, 4 weeks, and 6 weeks in Cho/NAA, Lac/ |
| S04 | Thursday 13:15 - 15:15 | Moderators: Wei Huang & Kei Yamada |
| 1157 | 13:15
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Investigating Oxygen Sensitive MRI to Provide Prognostic Biomarkers for Tumor Radiation Response |
1Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, United States |
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Prognostic imaging biomarkers to assess tumor hypoxia remain a Holy Grail. We present evidence that T1-weighted signal response to an oxygen breathing challenge before a single high dose of radiation is related to long term tumor control. Specifically, Dunning prostate R3327-AT1 tumors showing a small signal response showed poor control for relatively lower doses (30-50 Gy). Meanwhile, higher doses overcame the radio resistance, which we associate with hypoxia. A large BOLD response (ΔR2*) was associated with poor outcome irrespective of radiation dose. These results provide further evidence for the potential utility of oxygen sensitive MRI in guiding radiation therapy. |
| 1158
|
13:27
|
Multi-modality molecular imaging with hyperpolarized [1-13C]pyruvate MRSI and 18FDG-PET of early tumor response to a novel TRAIL agonist (MEDI3039) |
1CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 2CRUK Beatson Institute, Glasgow, United Kingdom, 3Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom |
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This study compared the capability of 3D magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized [1-13C]pyruvate metabolism and 18FDG-PET to detect early responses to a TRAIL agonist (Medimmune MEDI3039) in Colo205 colorectal cancer and MDA-MB-231 triple-negative breast cancer xenograft models expressing luciferase and mStrawberry fluorescent protein. 24 hours after treatment, bioluminescence and hyperpolarized lactate/pyruvate ratio decreased significantly in all treated animals, preceding decreases in tumor volume. Conversely, 18FDG-PET did not detect treatment response. This suggests that for some tumors hyperpolarized [1-13C]pyruvate may be an improvement on 18FDG-PET and RECIST for the early detection of treatment response. |
| 1159 | 13:39
|
Tracking the evolution of individual prostate cancer metastases in patients under the selective pressure of Radium-223 treatment using whole-body radiomics. |
1Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom, 2MRI Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom, 3Urology Department, The Royal Marsden NHS Foundation Trust, London, United Kingdom |
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Whole-Body Diffusion-Weighted-MRI is emerging as an imaging response biomarker in metastatic bone disease. Tumour heterogeneity resulting in differential response to therapy is a well-recognized phenomenon. We propose that calculating radiomic features from the apparent diffusion coefficients within individual lesions can identify differential response patterns in whole-body bone disease. Robust statistical assessment of radiomic features based on repeatability assessment aids identification of significant changes. |
| 1160 | 13:51
|
Predicting the spatio-temporal evolution of tumor vasculature and cellularity following whole brain radiation therapy |
1Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX, United States, 2Department of Diagnostic Medicine, The University of Texas at Austin, Austin, TX, United States, 3Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, United States, 4Livestrong Cancer Institutes, The University of Texas at Austin, Austin, TX, United States |
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A fundamental challenge in the care of patients with brain tumors is the limitation of standard radiographic measurements to accurately evaluate, let alone predict, patient response. To address this challenge, we have developed a biophysical model of tumor growth, angiogenesis, and response to radiation therapy that is calibrated on a subject-specific basis using diffusion-weighted and dynamic contrast enhanced MRI data. We evaluated the predictive accuracy of the model in rats with C6 gliomas receiving whole brain radiation. The model accurately predicted future tumor volume (error ranged from 12.1 to 18.5%). |
| 1161
|
14:03
|
Susceptibility contrast-MRI predicts response to the vascular endothelial growth factor receptor inhibitor cediranib in the Th-MYCN model of neuroblastoma |
1Division of Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom, 2Division of Clinical Studies, Institute of Cancer Research, London, United Kingdom, 3Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom |
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In this study we demonstrate that fractional blood volume, measured by susceptibility contrast-MRI, predicts response to the vascular endothelial growth factor receptor inhibitor cediranib in the Th-MYCN genetically-engineered mouse model of neuroblastoma. |
| 1162 | 14:15
|
The Effect of Altered Glucose Utilization on Dynamic GlucoCEST in a Preclinical Model of Glioblastoma |
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, 3Radiology College, Guizhou Medical University, Guiyang, China, 4Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, Guangzhou, China, 5Department of Medical Radiation Physics, Lund University, Lund, Sweden, 6Department of Ultrasound, Guangzhou Panyu Central Hospital, Guangdong, China, 7Division of Cancer Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 8Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong |
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To investigate the origin of glucoCEST contrast, we altered glucose utilization using an mTOR inhibitor (rapamycin) and studied dynamic glucoCEST signals in a human glioblastoma mouse model. By inhibiting glucose transport, cellular uptake and metabolism are suppressed and the perfusion of vessels and leakage into extravascular extracellular space highlighted. A great increase in glucoCEST contrast was seen in tumors in mice with the inhibitor compared to without. This provides evidence of a large extracellular glucose contribution to glucoCEST, and suggests that we can use glucoCEST to monitor the efficacy of rapamicin with respect to its inhibitory effect. |
| 1163 | 14:27
|
Radiomics of DCE-MRI to selectively down-stage the risk of breast cancers with a high-risk 70-gene signature |
1Image Sciences Institute, UMC Utrecht, Utrecht, Netherlands, 2Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands |
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The 70-gene signature (70GS) is a prognostic marker for patient survival that is used to guide treatment decisions. For a dataset of early-stage breast cancer patients, the 70GS were established retrospectively. We investigated the potential of DCE-MRI to stratify patient survival within the high-risk 70GS group. Eigentumor analysis and 3D lesion texture features from washin and post-contrast images were compared in survival analysis and hazard ratios were computed. Results show that the investigated features are able to significantly stratify survival, and suggest that radiomics of DCE-MRI may have complementary value to the 70-gene signature to reduce overtreatment. |
| 1164 | 14:39
|
Predicting breast cancer patient survival using textural features in CE MR images |
1Department of Circulation and Medical Imaging, NTNU, Trondheim, Norway, 2Department of Radiation Oncology, NYU Langone Health, New York, NY, United States, 3Cancer clininc, St. Olavs University Hospital, Trondheim, Norway, 4Department of Clinical and Molecular Medicine, NTNU, Trondheim, Norway, 5Department of Radiology, St. Olavs University Hospital, Trondheim, Norway, 6Radiology department, Hull & East Yorkshire Hospitals NHS Trust, Hull, United Kingdom, 7Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States |
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Treatment for women with locally advanced breast cancer (LABC) is determined with inadequate knowledge of the long-term outcome. We evaluated the prognostic value of textural features derived from pre-treatment CE-MRI in 55 LABC patients scheduled for neoadjuvant chemotherapy. Using overall survival at 7-years follow-up as endpoint, textural features derived from post-contrast pre-treatment images were significantly different. Using all textural features as input for multivariate analysis, we achieved a classification accuracy of 72% (p<0.001), which increased to 78% when including traditional prognostic factors (p<0.001). Textural features provide prognostic information, which can complement the stratification of patients to treatment. |
| 1165 | 14:51
|
Proton MRS-Detected Creatine Metabolic Profiles in Human Breast Cancer Cells Correlate with the Prognostic Indicator Ubiquitous Mitochondrial Creatine Kinase (CKMT1) |
1Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States |
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Ubiquitous mitochondrial creatine kinase (CKMT1) is an important mitochondrial membrane component responsible for the reversible conversion of creatine (Cr) to phosphocreatine (PCr). This study shows that in five breast cell lines of varying aggressiveness, 1H MRS-detected PCr levels correlated with CKMT1 mRNA expression. CKMT1 expression was significantly downregulated in triple-negative breast cancer cells compared to estrogen receptor (ER)/ progesterone receptor (PR)-positive cells, and nonmalignant cells. CKMT1 is a prognostic indicator in several cancers; thus, PCr holds promise as potential marker for improved cancer diagnosis, patient stratification, and theranostic treatment monitoring. |
| 1166 | 15:03
|
Radiomics subtyping improves 5-year disease free survival prediction beyond key clinical and radiological characteristics in patients with locally advanced rectal cancer (LARC) |
1Department of Radiation Oncology, Rutgers-The State University of New Jersey, New Brunswick, NJ, United States, 2Department of Radiological Sciences, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China, 3Institute of Translational Medicine，Zhejiang University, Hangzhou, China, 4Department of Electrical Engineering, Columbia University, New York, NY, United States |
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In this study, we have identified an 11-feature set from a large panel of radiomics signature (5248 features from pre-operative T1w, T2w, DCE and DWI images) that allows prediction of 5-year disease free survival of locally advanced rectal cancer patients underwent surgical resection. The selected radiomics signature demonstrates improved performance compared with that of established clinical and radiological risk models. The results were tested and validated on a consecutive 165-patient cohort with an average of 54±20 months follow-ups. |
| S05 | Thursday 13:15 - 15:15 | Moderators: Maxim Zaitsev & Daniel Gallichan |
| 1167 | 13:15
|
Markerless real-time motion correction for T1- and T2-weighted neuroanatomical MRI |
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 2Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, 3Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, 4Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, United States, 5Radiology, University of Pennsylvania, Philadelphia, PA, United States |
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This study investigates real-time head motion correction using markerless tracking of the subject's face to mitigate the major problems caused by patient movement in clinical and research MRI. The effects of motion include repeat scanning, impaired clinical diagnosis, need for sedation or anesthesia, and biased research results. Markerless tracking and correction is appealing because it could offer minimal disruption to the MRI workflow, sequence independence, and high-frequency motion estimation. Real-time correction substantially improved T2-SPACE and MPRAGE image quality in scans with intentional motion, compared to uncorrected scans. Cortical surface reconstructions, brain structure volumes, and cortical thickness estimated from the motion-corrected MPRAGE scan showed good correspondence with the gold standard scans without intentional movement. Markerless real-time correction is a promising approach to reduce the effects of motion in neuro MRI. |
| 1168 | 13:27
|
Simultaneous detection of cardiac, respiratory, and rigid body head motion using the scattering of a parallel transmit RF coil at 7T |
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, OXFORD, United Kingdom, 2University of Oxford Centre for Magnetic Resonance Research, University of Oxford, OXFORD, United Kingdom, 3Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Oxford, United Kingdom, 4British Heart Foundation Centre of Research Excellence, Department of Cardiovascular Medicine, Oxford, OXFORD, United Kingdom |
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Cardiac pulsation, respiration and rigid-body head motion induce changes in relative tissue conductivity. These changes can be detected via the scattering of a parallel transmit RF coil array at 7T, by monitoring the forward and reflected power of each channel, with a 5ms pulse. The time series of the scattering data can be used to detect cardiac and respiratory motion, as well as predict head position using training data. We show that detected heart and respiration rates match those recorded with independent monitoring, and head position may be predicted with reasonable precision, at little extra time cost. |
| 1169
|
13:39
|
Noise navigator based motion detection and compensation |
1Radiotherapy, UMC Utrecht, Utrecht, Netherlands |
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The feasibility of irregular and unpredictable motion detection and retrospective head motion artifact removal was demonstrated based on the noise navigator. The key advantages of the noise navigator are its inherent synchronization with MR acquisition, compatibility with most read-out strategies and no additional acquisition or hardware is required. Only the raw k-space data needs to be available for this method. |
| 1170
|
13:51
|
Prospective Motion Correction in Multiband fMRI Using Multislice-to-Volume Image Registration |
1Fraunhofer MEVIS, Bremen, Germany, 2University of Bremen, Bremen, Germany, 3Imaging Centre of Excellence, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, Scotland |
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This study introduces an image-based technique for prospective motion correction in multiband fMRI utilizing multislice-to-volume image registration. Motion detection is based on a single multiband excitation and readout, which allows a high temporal resolution and does not depend on the repetition time or the total number of slices. Results show high accuracy in correcting involuntary as well as intentional head movements in typical fMRI experiments. Residual motion parameters were observed to be within the ranges ±0.2mm/±0.2° without and ±0.5mm/±0.5° with intentional head movements. Comparison with volume-to-volume based prospective motion correction demonstrated an improved performance for high-frequency components of motion. |
| 1171 | 14:03
|
Robust rigid-body motion estimation from extremely short subsets of 3D Cartesian scans |
1Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Radiology, University of Cincinnati, School of Medicine, Cincinnati, OH, OH, United States |
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In this work, the ability to accurately co-register 3D volumes reconstructed from subsets of a variable-density 3D Cartesian acquisition is shown. Accurate rigid-body motion correction was possible for undersampling factors as high as a factor of 125 in a brain imaging application employing a 32-channel head coil. This enables efficient retrospective motion correction without loss of scan efficiency and without the need for any specialized MR hardware. This approach may help reduce the incidence of failed scans due to motion, potentially leading to a reduction for the need for sedation in pediatric patients. |
| 1172 | 14:15
|
Data-Driven Correction of B0-off-resonance fluctuations in gradient-echo MRI |
1Philips Research Europe, Hamburg, Germany |
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B0-off-resonance fluctuations can lead to artifacts in gradient-echo MRI with long echo-times. This work presents a purely data-driven method to estimate and correct for any B0-off-resonance fluctuation occurring during scanning, without additional data acquisition, navigator or image-processing. The estimated B0-off-resonance fluctuations are shown to be highly correlated with the signal from a respiratory bellows, the spatial variation of the fluctuations can be determined by exploiting the spatially varying coil sensitivities and histograms of R2* measurements show reduced variance. |
| 1173 | 14:27
|
Rigid motion corrected low rank magnetic resonance fingerprinting |
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Philips Healthcare, Guildford, United Kingdom |
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Magnetic Resonance Fingerprinting (MRF) is a novel transient state relaxometry method that simultaneously estimates multiple quantitative tissue parameters. Motion occurring during the MRF acquisition can propagate errors into the parametric maps. Here we propose a novel motion corrected low rank method (MC-MRF) to simultaneously correct for rigid body motion and accelerate the scan. We investigated MC-MRF to correct for 2D in-plane motion on standardized phantom and in-vivo acquisitions. Additionally, we investigated the effect of through-plane motion in 2D MRF. Successful motion correction is achieved with MC-MRF for in-plane motion. Residual artefacts remain from through-plane motion after 2D retrospective motion correction. |
| 1174 | 14:39
|
Motion Correction in MRI using Deep Convolutional Neural Network |
1Monash Biomedical Imaging, Monash University, Melbourne, Australia, 2School of Psychological Sciences, Monash University, Melbourne, Australia, 3Department of Electrical and Computer System Engineering, Monash University, Melbourne, Australia, 4Institute of Medicine, Research Centre Juelich, Juelich, Germany |
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Patient motion during MR data acquisition appears in the reconstructed image as blurring and incoherent artefacts. In this work, we present a novel deep learning encoder-decoder convolutional neural network (CNN) that recasts the problem of motion correction into an artefact reduction problem. A CNN was designed and trained on simulated motion corrupted images that learned to remove the motion artefact. The motion compensated image reconstruction was transformed into quantized pixel classification, where each pixel in the motion corrupted MR image was classified to its uncorrupted quantized value using a trained deep learning encoder-decoder CNN. |
| 1175 | 14:51
|
Correction of motion artifacts using a multi-resolution fully convolutional neural network |
1Philips GmbH Innovative Technologies, Hamburg, Germany, 2Philips Radiology Solutions, Seattle, WA, United States, 3Department of Radiology, University of Washington, Seattle, WA, United States |
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Motion artifacts are a frequent source of image degradation in clinical practice. Here we demonstrate the feasibility of correcting motion artifacts in magnitude-only MR images using a multi-resolution fully convolutional neural network. Training and testing datasets were generated using artificially created artifacts introduced onto in vivo clinical brain scans. Both the corrupted input and filtered output images were rated by an experienced neuroradiologist. |
| 1176 | 15:03
|
Non-rigid Brain MRI Registration Using Two-stage Deep Perceptive Networks |
1School of Automation, Northwestern Polytechnical University, Xi'an, China, 2Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 3School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China |
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Non-rigid image registration is a fundamental procedure for the quantitative analysis of brain images. The goal of non-rigid registration is to obtain the smooth deformation field that can build anatomical correspondences among two or more images. Conventional non-rigid registration methods require iterative optimization with careful parameter tuning, which is less flexible when dealing with the diverse data. Therefore, we propose a two-stage deep network to directly estimate the deformation field between an arbitrary pair of images. This method can tackle various registration tasks, and is consistently accurate and robust without parameter tuning. Thus, it is applicable to clinical applications. |
| S06 | Thursday 13:15 - 15:15 | Moderators: Victoria Chernyak & Yasser Abbas |
| 1177
|
13:15
|
Cervical cancer staging and surveillance using Restriction Spectrum Imaging (RSI)-MRI in comparison to PET-CT: Pilot Clinical Application |
1Radiology, University of California, San Diego, San Diego, CA, United States, 2Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, CA, United States, 3Radiology & Neurosciences, University of California, San Diego, La Jolla, CA, United States |
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This proof of concept study suggests restriction spectrum imaging (RSI)-magnetic resonance imaging (MRI) provides similar cervical cancer staging and surveillance information compared to standard of care MP-MRI and PET-CT. Advantages over the standard of care modalities may include improved cost-effectiveness, brevity, radiation-free, and contrast media-free. Pilot cases suggest that RSI-MRI cellularity index can detect residual and recurrent tumor in post-treatment cervical cancer patients with similar sensitivity to PET-CT. RSI-MRI has the advantage of minimal false positive results related to radiation-related post-treatment changes that often confound interpretation of PET-CT. |
| 1178 | 13:27
|
MR R2* values in diagnosing the stage Ia and Ib endometrial carcinoma |
1Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China, 2GE Healthcare, Beijing, China |
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Endometrial carcinoma(EC) patients staged stage Ia or Ib have different operation methods and prognosis. To evaluate the value of enhanced T2*-weighted angiography(ESWAN) in the differential diagnosis between stage Ia and Ib of endometrial carcinoma. In this work, we found it is feasible that ESWAN sequence derived R2* value can be applied in the differential diagnosis between stage Ia and Ib of endometrial carcinoma, which can provide detailed information for clinical treatment. |
| 1179 | 13:39
|
Ex vivo MRI evaluation of vulvar cancer in fresh wide local excision specimens for cancer localization and prediction of the surgical tumour free margins. |
1Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, 2Obstetrics and Gynaecology, Radboud university medical center, Nijmegen, Netherlands, 3Pathology, Radboud university medical center, Nijmegen, Netherlands, 4Operating Rooms, Radboud university medical center, Nijmegen, Netherlands |
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Currently, perioperative information on the surgical margin status of wide local excision specimens containing vulvar cancer is only based on the surgeon’s estimation. In this study we performed both a non-blinded and a blinded annotation of vulvar cancer location and surgical tumour free margins in the ex vivo MRI obtained from fresh wide local excision specimens. Annotated whole-mount section histopathology slides obtained from totally included specimens were adhered as gold standard. There was high correlation and agreement between ex vivo MRI, and high NPV and PPV were obtained for vulvar cancer localization and identification of margins <8 mm. |
| 1180 | 13:51
|
Texture analysis of multiparametric MRI in cervical cancer before and after chemoradiotherapy |
1Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2Philips Healthcare, Hong Kong, Hong Kong |
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Texture analysis of multiparametric MRI (mpMRI) consisting of diffusion-weighted MRI (DWI) and T2-weighted (T2W) texture features could be a promising quantitative approach in assessing tumor heterogeneity. We retrospectively studied forty patients who had paired mpMRI examinations before and at week-4 of chemoradiotherapy (CRT). Based on the changes in stable mpMRI features, we observed that initially more anatomically and functionally homogenous tumors had better response to treatment and that tumors became more functionally heterogenous after treatment. |
| 1181
|
14:03
|
Multivariate Analysis including Biological Biomarkers, Diffusion-Weighted Imaging, T1 and T2 Mapping for Renal Fibrosis Prediction |
1Radiology, University of Geneva, Geneva, Switzerland, 2University Hospital of Geneva, Geneva, Switzerland, 3University of Geneva, Geneva, Switzerland |
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Recently, the cortico-medullary difference in Apparent Diffusion Coefficient (ΔADC) from (RESOLVE) diffusion-weighted imaging (DWI with readout segmentation of long variable echo train) allowed the classification of kidney allograft patients according to whether they had more or less than 40% interstitial fibrosis. In this study, ΔADC was externally validated, with a very good AUC, as an index to identify patients with more than 40% fibrosis in a larger and mixed population of 130 patients. In addition, a mixed scoring including the combination of routinely obtained serologic markers including eGFR, and MRI-derived (ΔADC and ΔT1) was proposed to improve renal fibrosis prediction. |
| 1182
|
14:15
|
MR Elastography, Diffusion Imaging and BOLD-Imaging for the Detection of Early Changes of Renal Stiffness in Patients with Lupus Nephritis |
1Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Rheumatology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany |
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Renal stiffness was investigated using MR elastography (MRE) and tomoelastography data processing in healthy controls and patients with lupus nephritis (LN). Our results showed that patients had lower renal stiffness than controls, while subregions such as medulla and inner cortex allowed to differentiate early chronic kidney disease (CKD=1) from progressed disease stages based on MRE values. The observed reduction in renal stiffness is associated with decreased ADC-values and increased T2*-values due to LN with CKD≥2. The decreased stiffness due to CKD=1 was reflected by T2*-values but not by ADC-values. MRE provided the highest diagnostic accuracy for detection of LN. |
| 1183 | 14:27
|
Diffusion-weighted magnetic resonance imaging in bladder cancer: comparison of readout-segmented EPI and single-shot EPI Techniques |
1Radiology, Changhai Hospital of Shanghai, Shanghai, China |
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Diffusion weighted imaging showed the potential to assess bladder cancer. This study aimed to investigate whether readout-segmented EPI can offer better image quality in imaging bladder patients in comparison with single-shot EPI, and to compare quantitative image parameters, derived from RS-EPI with those of SS-EPI. Thirty-five patients were examined using both diffusion techniques. There were significant differences in susceptibility artifacts, lesion detectability, image blurring, CNR and SIR values, except for motion artifacts, SNR and ADC values of the bladder lesions. This study found that the RS-EPI technique provides significant image quality improvement compared with SS-EPI in bladder at 3 Tesla. |
| 1184 | 14:39
|
4D flow MRI in renal transplant: preliminary results. |
1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, 2Radiology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, 3University Hospital Zurich, Zurich, Switzerland, 4Groupe Hospitalier Pitie-Salpetriere, Paris, France, 5Feinberg School of Medicine, Radiology, Northwestern University, Chicago, IL, United States, 6McCormick School of Engineering, Biomedical Engineering, Northwestern University, Chicago, IL, United States, 7Recanati-Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, 8Pathology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States |
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In this preliminary study, we sought to determine the test-retest repeatability of flow quantification in renal allograft vessels using a 4D flow phase-contrast (PC) MRI sequence, and to correlate flow parameters with renal function. We observed significantly decreased renal arterial flow in allografts with chronic dysfunction, as well as positive correlation between flow and velocities in renal transplant vessels and renal function. We conclude that 4D flow imaging is sensitive to the vascular changes that accompany renal transplant dysfunction, to be confirmed in a larger study. |
| 1185
|
14:51
|
Free-breathing R2* Mapping in the Entire Placenta During Early Gestation Using 3D Stack-of-Radial MRI at 3 T: Investigation of Spatial and Temporal Variation |
1Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, 2Physics and Biology in Medicine, University of California Los Angeles, Los Angeles, CA, United States, 3Epidemiology, University of California Los Angeles, Los Angeles, CA, United States, 4Pediatrics, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, United States, 5Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, United States |
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Current methods for detecting ischemic placental disease are either invasive or have low sensitivity. MRI can be used to non-invasively characterize tissue hypoxia with R2* mapping. However, conventional Cartesian MRI methods are sensitive to motion artifacts due to maternal and fetal motion. In this study, a non-Cartesian free-breathing 3D stack-of-radial MRI technique (FB radial) for R2* mapping in the placenta during early gestation was investigated at 3T. In 20 subjects, placental R2* range, accuracy, repeatability, spatial variation, and temporal variation were analyzed. Results demonstrate that FB radial is an accurate and repeatable technique for R2* mapping in the entire placenta. |
| 1186 | 15:03
|
Placental Metabolic Rate of Oxygen |
1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 3Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Pennsylvania, Philadelphia, PA, United States |
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Placental dysfunction is widely accepted as a major cause of common adverse pregnancy outcomes. However, current clinically available tools are limited in their ability to assess placental function. Here, we have incorporated quantitative MRI methods to estimate placental metabolic rate of O2 (PMRO2), which may contribute to the understanding of placental dysfunction. Presented results demonstrate the feasibility of estimating PMRO2 in vivo. Further, these data suggest, in a limited number of participants, that PRMO2 may in fact contribute to the understanding of pregnancy complications. |
| W05/06 | Thursday 13:15 - 15:15 | Moderators: Pooja Gaur & Michael Bock |
| 1187 | 13:15
|
Feasibility of Blood-Brain Barrier Opening in Patients with Alzheimer’s Disease by MR-Guided Focused Ultrasound |
1Sunnybrook Research Institute, Toronto, ON, Canada, 2Division of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 3Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada, 4Division of Neurology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 5Division of Geriatric Psychiatry, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 6Department of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 7Department of Psychiatry and Behavioral Sciences and Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, United States, 8Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada |
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In a phase I clinical trial, the feasibility and safety of focal blood-brain barrier (BBB) opening in patients with Alzheimer’s disease using the ExAblate focused ultrasound system was evaluated. Six patients were treated in the white matter of the prefrontal cortex. It was demonstrated that BBB opening can be achieved without any red-blood-cell extravasation. |
| 1188 | 13:27
|
Noninvasive neuromodulation induced by focused ultrasound combined with fMRI in the non-human primate brain |
1Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou City, China, 2School of Medicine, Department of Electrical Engineering, Chang Gung University, Taoyuan County, Taiwan, 3Department of Biomedical Engineering, National Yang-Ming University, Taipei City, Taiwan |
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Currently, the field of neuromodulation using focused ultrasound is growing due to its potential clinical applications. Using the lab-designed MRI-compatible FUS transducer and 7T research MRI system with the customer-made transmit/receive surface coil, the current study demonstrated that focused ultrasound (FUS) can induce BOLD responses in visual cortex in non-human primate. The effect of FUS could sostenuto influence the neuron activity in the visual cortex to enhance BOLD responses evoked by visual stimulus. FUS combined with fMRI has potential to explore the mechanism of neuromodulation in NHP induced by focused ultrasound. |
| 1189 | 13:39
|
In vivo MR-ARFI for transcranial focused ultrasound in large animals |
1Radiology, Stanford University, Stanford, CA, United States, 2Electrical Engineering, Stanford University, Stanford, CA, United States |
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Focused ultrasound through the skull is desirable for noninvasive brain therapies such as neuromodulation. However, the skull distorts the ultrasound beam and absorbs varying amounts of energy depending on bone thickness and composition. In light of these challenges, we investigate magnetic resonance acoustic radiation force imaging (MR-ARFI) focal spot imaging of subcortical brain tissue in a large animal, and simulations and measurements of acoustic pressure transmitted through the skull. Results show in vivo MR-ARFI focal spot imaging through the skull for the first time, and provide practical information on focal spot targeting through skulls of varying shape, thickness, and composition. |
| 1190 | 13:51
|
Focus Correction in MR Thermometry for Precise Targeting in Focused Ultrasound Thalamotomy for Essential Tremor: Statistical Study from 121 Sonications in 7 Patients |
1Physics, Soochow University, Taipei, Taiwan, 2Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 3Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States |
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Focused ultrasound thalamotomy was approved by FDA for the treatment of essential tremor under MRI guidance. However, spatial errors in the location of focal spots are often observed and could jeopardize the patient safety if not taken into account. We previously explained the causes of this error and proposed a correction method. Using the method, data associated with 121 sonications from 7 patients were statistically analyzed in the present study. Results show the focus was shifted by 0.05 mm/°C. The size of shift for treating sonication agrees with the value reported in literature. |
| 1191 | 14:03
|
Interleaved scanning for MR-guided High Intensity Focused Ultrasound mediated drug delivery |
1Oncology Solutions, Philips Research, Cologne, Germany, 2Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands, 3Philips Research, Hamburg, Germany, 4Department of Radiology, Experimental Imaging and Image-guided Therapy, University Hospital of Cologne, Cologne, Netherlands |
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MR-guided High Intensity Focused Ultrasound (MR-HIFU) is a method that allows non-invasive heating of lesions to well-controlled ablative or hyperthermic temperatures. Control of acoustic power and focus position is achieved using a feedback based on MR thermometry. Local hyperthermia can be used as a trigger for image guided drug delivery using temperature sensitive liposomes co-encapsulating doxorubicin and MR contrast agent. The challenge is to acquire both temperature and R1-maps during hyperthermia dynamically. We investigated a novel MR method interleaving both acquisitions, with their own temporal resolution, without compromising temperature feedback showing a gradually increase of contrast agent inside rat tumors. |
| 1192 | 14:15
|
An experimental model for mild hyperthermia with predictive temperature control in osteolytic bone metastases, using MR-guided focused ultrasound. |
1Radiology, Geneva University Hospitals, Image guided Interventions Laboratory, Geneva, Switzerland, 2Radiation Oncology, Geneva University Hospitals, Geneva, Switzerland |
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Combination of hyperthermia with ionizing radiation is strongly compelling, based on principles of classic radiobiology, molecular biology, and tumor physiology. MR-guided focused ultrasound (MRgFUS) is a “touch-less” approach already employed for ablative pain palliation of symptomatic bone metastases (SBM). MRgFUS mild hyperthermia adjuvant to radiation therapy has not been reported for SMB pain palliation. We optimized here the geometry of MRgFUS sonication and the automatic temperature control during steady-state long lasting hyperthermia using a realistic ex-vivo anatomic model mimicking osteolytic bone tumors. The results demonstrated uniform spatio-temporal heating, together with predictable and safe thermal condition of the cortical bone. |
| 1193 | 14:27
|
Correction of focused ultrasound beam defocusing in heterogeneous soft tissues |
1Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, 2Bioengineering, University of Utah, Salt Lake City, UT, United States, 3Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, United States |
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Soft tissue MRgFUS treatments can be adversely affected by aberration of the focused ultrasound beam due to speed of sound differences between heterogeneous tissues. A quasi-real time beam aberration correction technique that uses an MRI derived model is presented and experimentally validated in a heterogeneous breast-mimicking phantom model. Comparison of MRgFUS sonications performed with and without phase aberration correction demonstrates that this model-based correction algorithm results in improved MRgFUS treatment efficiency and accuracy. This is shown to affect both thermal and mechanical MRgFUS applications. |
| 1194 | 14:39
|
Intra-vascular, MRI-Guided, perivascular ultrasound ablation with thermometric monitoring of therapy delivery |
1Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, United States, 2Russell H. Morgan Dept. of Radiology, Johns Hopkins University, Baltimore, MD, United States, 3Acertara Acoustic Laboratories, Longmont, CO, United States, 4Acoustic MedSystems, Inc, Champaign, IL, United States |
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Vessel invasion from a tumor is a major challenge for both surgical resection and extracorporeal HIFU ablation. Conceivably, an intravascular ultrasound ablation catheter combined with an intravascular high-resolution MRI coil could precisely target and monitor of peri-vascular therapy delivery that preserves the vessel wall via MRI thermometry. We present results from an intra-vascular 3T ultrasound ablation/MRI antenna probe that document MRI thermometry-based thermal dosage and lesion formation in porcine liver and chicken specimens with vessel wall preservation. A simple motion-correction method that employs the antenna’s intrinsic sensitivity profile as a navigator for thermometry is tested in vivo. |
| 1195 | 14:51
|
Long-Term Volumetric Thermometry for Measurement of Diffuse Tissue Heating during MRgFUS Treatments |
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States |
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Currently, PRF MR thermometry is commonly used for temperature monitoring and thermal dose estimation during MRgFUS treatments. The temperature is calculated based on the phase change between the current image and the baseline image, which is acquired before each sonication starts. This does not account for residual heat from previous sonications. In this work, we have developed a volumetric long-term thermometry technique to measure the change in temperature of the entire region of treatment for the duration of the procedure |
| 1196 | 15:03
|
Evaluation of 2D simultaneous multi-slice EPI at 1.5T for MR-thermometry in presence of motion. |
1IHU Liryc, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Université, Bordeaux, France, 2Univ. Bordeaux, Centre de recherche Cardio-Thoracique de Bordeaux, U1045, Bordeaux, France, 3INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, U1045, Bordeaux, France, 4Image Guided Therapy SA, Bordeaux, France, 5Institute of Mathematics of Bordeaux, UMR 674 5251, Bordeaux, France, 6Siemens Healthineers, Saint Denis, France, 7Siemens Healthcare, Saint Denis, France, 8Siemens Healthcare, Erlangen, Germany |
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Temperature mapping in presence of respiratory motion can accommodate intra-scan motion using fast 2D-EPI sequence but inter-scan motion remains a challenge during free-breathing acquisition. To address this limitation, we evaluated, in vitro on a mobile gel, a 2D simultaneous multi-slice EPI sequence with a slice acceleration factor up to 3 during radiofrequency ablation. Inter-scan motion and temperature elevation measured with accelerated sequences are compared to reference values using a non-accelerated sequence. Additionally, evidence or absence of potential false-positive heating are considered. |
| Exhibition Hall | Thursday 14:15 - 15:15 | (no CME credit) |
| W07 | Thursday 15:30 - 16:30 | (no CME credit) |
Organizers: Matthew Budde, Alex Rovira, Hugo Vrenken
| N04 | Thursday 15:30 - 17:30 | (no CME credit) |
15:30
|
Introduction | |
15:35
|
Data Sharing Initiatives in Neuroimaging & Beyond: Experiences & Lessons Learned | |
1Danish Research Centre for MR |
15:58
|
Successes of Big Data & Data Sharing in Understanding Neurological Diseases | |
1Neuroimaging Research Unit, San Raffaele Scientific Institute, Milan, Italy |
16:21
|
Analysis Pipeline Sharing: Making Life Easier? | |
16:44
|
Public Engagement 2.0: On the Possibilities of "Citizen Science" | |
1Institut Pasteur |
17:07
|
What Can Learning Machines Teach Us About the CNS? | |
1University College London |
Organizers: Kristine Glunde, Natalie Serkova
| W03/04 | Thursday 15:30 - 17:30 | Moderators: Kristine Glunde & Natalie Serkova | (no CME credit) |
15:30
|
Introduction to Animal Imaging in Translational Research |
15:35
|
Animal Handling for an Imaging Study: Do We Really Do It Correctly? | |
1University of Calgary, Canada |
15:55
|
State-of-the-Art MRI/MRS in Animal Research: Novel MR Contrast; Multinucear (Including Hyperpolarized) MRS; Treatment Response | |
1Robarts Research Institute, Canada |
16:15
|
Molecular Imaging Beyond MRI: Novel PET Radiotracers & Applications, Optical Imaging | |
| TBD |
16:35
|
Vascular Imaging in Animal Research: MRI, MicroCT, Ultrasound | |
1Radiology, Johns Hopkins University, Baltimore, MD, United States |
16:55
|
Multi-Parametric Image Analysis: Quantitative Image Analysis & Multi-Parametric Multi-Modal Imaging Biomarkers | |
17:15
|
Panel Discussion |
Organizers: Adrienne Campbell-Washburn, Edward DiBella, Eric Stinson, Dominik Von Elverfeldt
| S02 | Thursday 15:30 - 17:30 | Moderators: Adrienne Campbell-Washburn & Eric Stinson |
15:30
|
Artifact Game Show | |
1Mayo Clinic, Rochester, MN, United States, 2National Institutes of Health, Bethesda, MD, United States, 3Uniklinik-Freiburg, Freiburg, Germany, 4University of Utah, Salt Lake City, UT, United States |
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Come participate in the ISMRM Artifact Game Show! Learn about common MR artifacts and how to avoid them in a light-hearted game show setting. Contestants will participate in a variety of games to learn about artifacts, and then experts will provide more information. If you’re in the room, you have the chance to play! Come for the artifacts, stay for the fun and prizes! |
17:30
|
Adjournment & Meet the Teachers |
Organizers: Marcus Alley, Bernd Jung
| S01 | Thursday 15:30 - 17:30 | Moderators: Joseph Cheng & Bernd Jung |
15:30
|
Artifacts to Artefacts | |
1University Hospital Bern, Switzerland |
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Imaging artifacts are routinely encountered in MR clinical practice. Therefore the presentation focuses on 1) the understanding why MR artifacts arise, 2) the identification of key artifacts and to understand their origins, 3) the elimination or mitigation of artifacts (if desired or possible), and 4) artifacts that can be utilized for diagnostic purposes. |
16:10
|
Contrast Agents, Focusing on the Gadolinium Chelates and Safety | |
1INSELSPITAL, Universitätsspital Bern, Switzerland |
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The gadolinium chelates (the GBCAs) are critical to disease diagnosis by MR, indeed to clinical medicine worldwide, and have proven to be overall a very safe class of contrast media. This review focuses on the current knowledge regarding accumulation of gadolinium in the brain (dentate nucleus and other structures) and body, with clinical recommendations based on that and other safety data, including discussion of the recent European Medicines Agency (EMA) ruling. |
16:50
|
High Field Imaging | |
1Physikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Germany |
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The MRI main field strength has been constantly increased over the past decades and today, scanners with 3T, 7T and even beyond are in use. However, ultrahigh-field (>7T) systems are still mostly used in research centers although a transition into hospitals is expected. The reasons for using (ultra-)high fields are multifold and will be outlined in this presentation Along with these benefits go a larger range of challenges, which are among the reasons for the rather slow transition of UHF into clinical applications. Solutions to most of these challenges will be presented and applications will be highlighted. |
17:30
|
Adjournment & Meet the Teachers |
Organizers: Christopher Hess, Alex MacKay
| N01 | Thursday 15:30 - 17:30 | Moderators: Christopher Hess & Alex MacKay |
15:30
|
Fast Imaging Techniques for Brain Imaging | |
1Karolinska University Hospital, Sweden |
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"Fast Imaging Techniques for Brain Imaging" is a wide topic. This presentation will focus on the most recent advances in fast brain imaging towards comprehensive clinical brain exams by acquiring multiple MR contrasts simultaneously in minimal scan time. |
16:00
|
Medical Applications of Fast MR Imaging of Brain | |
1Radiology, Mount Sinai Hospital, New York, NY, United States |
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The target audience of this talk are neuroscientists and clinicians including neurologists and neuroradiologists interested in the development and application of rapid brain MRI imaging. The objectives are: 1. To be familiar with the latest available methodology for fast brain MR imaging 2. Learn how to obtain routine brain MRI examinations in 5 minutes 3. Learn how to perform and interpret a 6-minute comprehensive stroke MR imaging 4. Accelerate brain vascular imaging using highly under sampled methodology:
- Compressed sensing for brain vessel wall imaging and MRA - k-t accelerated imaging for clinical brain 4D flow imaging |
| 1197 | 16:30
|
Highly Accelerated Multi-Contrast 3D Isotropic MRI in 5 Minutes: A Feasibility Study for Multiple Sclerosis |
1Chinese PLA General Hospital, Beijing, China, 2Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea, 3Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea, 4United Imaging Healthcare(UIH), Shanghai, China |
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Multiple sclerosis(MS) is a chronic disease that damages the nerves in the brain and results in multiple areas of scar tissues within the central nervous system. Multi-contrast structural MRI, which includes T1, T2, and FLAIR, has been routinely used in detecting MS lesions. Nevertheless, it is still challenging to accurately detect small MS lesions diffused over the entire brain due to the limitation of spatial resolution and long imaging time. The purpose of this work is to investigate the feasibility of achieving highly accelerated, multi-contrast 3D isotropic (~ 1.0 mm3) MRI (T1, T2, and FLAIR), which exploits sharable information across images, for detection of MS lesions over the whole brain roughly in 5 minutes. |
| 1198 | 16:45
|
Through-time and hybrid radial GRAPPA to improve the visualisation of velic motion in real-time speech MRI |
1Clinical Physics, Barts Health NHS Trust, London, United Kingdom, 2William Harvey Research Institute, Queen Mary University of London, London, United Kingdom |
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Aim: to investigate if radial GRAPPA could be used to: (a) improve velic motion visualisation when compared with standard protocols and reconstructions; (b) enable multislice imaging by sufficiently accelerating real-time MRI data acquisition. Methods: datasets of healthy adult volunteers were acquired at 3T and reconstructed using through-time and hybrid GRAPPA methods. Results: velic motion visualisation was superior in GRAPPA images than in images acquired using standard protocols and reconstructions. Multislice imaging (two slices) at 8fps per slice was achieved. Conclusions: radial GRAPPA shows promise as a method for use in clinical imaging of speech. |
| 1199 | 17:00
|
A multi-center study on fast full-brain quantitative multi-parameter mapping of R1, MT, and R2*: scan-rescan repeatability and inter-site reproducibility |
1Spinal Cord Injury Center Balgrist, University of Zurich, Zurich, Switzerland, 2Max Planck Institute for Human Cognitive and Brain Science, Leipzig, Germany, 3Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 4Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 5Brain MRI 3T Centre, C. Mondino National Neurological Institute, Pavia, Italy, 6Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom |
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We present a multi-center, multi-vendor study evaluating repeatability and reproducibility of quantitative MRI data acquired using high resolution (1 mm³) multi-parameter mapping which provides quantitative R1, MT and R2* maps of the whole brain within less than 18 min. The protocol was implemented at four clinical sites with different Siemens and Philips 3T MRI scanners. Scan-rescan measurements of the same five healthy volunteers at all sites showed good intra-site reproducibility in all parameter maps. However, the inter-site comparisons showed higher reproducibility within a single vendor than across vendors. |
| 1200 | 17:15
|
Multi-contrast EPI - Towards clinical application |
1MR Applied Science Laboratory Europe, GE Healthcare, Stockholm, Sweden, 2Karolinska University Hospital, Dept of Neuroradiology, Stockholm, Sweden, 3Karolinska Institute, Dept of Clinical Neuroscience, Stockholm, Sweden |
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We present an enhanced version of our multi-contrast EPI sequence which generates T1-FLAIR, T2-FLAIR, T2*w, T2w, iso-DWI, ADC images of 36 slices in 90 s. We introduce various optimization including tetrahedral diffusion encoding, different partial Fourier factors for the EPI trains and multi-echo acquisition for T2-FLAIR, T2*w, T2w, and DWI. The improved sequence is compared to our previous implementation and superior image quality is shown especially for the diffusion contrast. Finally, multi-contrast EPI patient data is shown and compared to conventional imaging sequences. |
17:30
|
Adjournment & Meet the Teachers |
| N02 | Thursday 15:30 - 17:30 | Moderators: Hua Guo & Trong-Kha Truong |
| 1201
|
15:30
|
3D Diffusion Imaging with SPiral Encoded Navigators from Stimulated Echoes (3D DISPENSE) |
1Department of Radiology, Academical Medical Center, Amsterdam, Netherlands, 2Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands |
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In this work, we present a new method for motion-insensitive 3D multi-shot diffusion imaging, by using 3D Diffusion Imaging with SPiral Encoded Navigators from Stimulated Echoes (3D DISPENSE). The 3D spiral navigator is acquired with a single readout and generated between diffusion preparation and image acquisition from the twin-pathway of the stimulated echo TSE imaging signal pathway. Therefore, the proposed 3D navigator technique does not compromise diffusion weighting or TSE readout efficiency. We demonstrated the feasibility of this method in phantoms, as well as by in vivo 3D high resolution artifact-free diffusion tensor imaging with nearly full brain coverage. |
| 1202
|
15:42
|
A 3D k-Space Fourier Encoding and Reconstruction Framework for Simultaneous Multi-Slab Acquisition |
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China |
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3D multi-slab acquisition is an important technique for high-resolution isotropic diffusion imaging. To further accelerate the acquisition, simultaneous multi-slice (SMS) excitation can be combined with multi-slab. Although either multi-slab or SMS acquisition can be described using a 3D k-space, it’s hard to describe simultaneous multi-slab (SMSlab) using a 3D k-space. In this study, it’s shown that by using RF modulation and gradient encoding together, SMSlab acquisition can also be described by a 3D k-space. It’s further demonstrated that parallel imaging techniques, such as 2D SENSE and 2D GRAPPA, can be used to recover the under-sampled k-space from SMSlab. |
| 1203 | 15:54
|
Distortion-Free, High-Resolution Diffusion Imaging in a Clinically-Feasible Scan Time on a Compact 3T MRI with High-Performance Gradients |
1Department of Radiology, Mayo Clinic, Rochester, MN, United States, 2GE Global Research, Niskayuna, NY, United States |
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DIADEM (Distortion-free Imaging: A Double Encoding Method) is a hybrid, multi-shot approach using a spin-warp and echo-planar phase-encoding strategy. It is inspired by the point-spread-function mapping method to enable distortion-free high-resolution diffusion imaging, which has a great potential for clinical practice. However, its prolonged scan time poses an obstacle for its adoption. We demonstrate that DIADEM achieves high-resolution (1.4 mm3 isotropic or 0.86 mm2 in-plane), distortion-free, and whole-brain, diffusion tensor images under 9 minutes scan time with: i) sequence optimization and ii) the high-performance gradients (80 mT/m, 700 T/m/s) on a compact 3T MRI. |
| 1204
|
16:06
|
Fast Distortion-Free Diffusion Imaging using “tilted-CAIPI” PSF-EPI |
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 3Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States |
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Single-shot EPI is widely used for diffusion imaging, but suffers from susceptibility-induced distortion and T2* blurring, which limit its resolution and ability to detect detailed structures. PSF-encoded EPI with an added 2D-navigator has recently been developed to allow distortion- and blurring- free diffusion imaging. However, the extremely long acquisition of PSF-EPI makes it impractical for high angular resolution diffusion imaging. In this work, PSF-EPI is accelerated by >20x using a novel “tilted-CAIPI” approach, along with self-navigation strategy. This has enabled distortion- and blurring-free diffusion imaging at 1.2mm isotropic to be acquired with 48 diffusion directions in 21-minutes for whole-brain. |
| 1205
|
16:18
|
Diffusion-prepared multi-shot bSSFP imaging with gradient stabilizer |
1Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 2Physics and Biology in Medicine IDP, University of California, Los Angeles, Los Angeles, CA, United States, 3Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 4Siemens Healthcare, Los Angeles, CA, United States, 5Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United States |
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A gradient stabilizer strategy was proposed to solve the k-space magnitude inconsistency problem in multi-shot diffusion-prepared bSSFP imaging. Simulation studies showed that the proposed approach is insensitive to phase errors during the diffusion encoding stage, and has built-in fat-saturation property. Phantom and in-vivo studies verified that adding gradient stabilizers could remove signal loss and artifacts, and provide repeatable artifact-free images. Combined with existing phase correction techniques, the proposed approach provided distortion-free high-quality 2D diffusion-weighted and diffusion tensor images, and has the potential of extending to 3D. |
| 1206
|
16:30
|
Can we correct for interactions between subject motion and gradient-nonlinearity in diffusion MRI? |
1CUBRIC, Cardiff University, Cardiff, United Kingdom, 2Royal United Hospitals Bath, NHS Foundation Trust, Bath, United Kingdom |
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Scanners with ultra-strong gradients promise unprecedented opportunities for diffusion imaging. However, their effective use requires correction of gradient-nonlinearity effects during data analysis. Although such techniques exist, they neglect the effects of motion which induces spatio-temporal variations in b-values and b-vectors. Here, we propose a technique that accounts for interaction of subject motion with such non-linearity and study its effectiveness by performing diffusion experiments with volunteers positioned in regions with incrementally increasing gradient-nonlinearities. Our experiments reveal the importance of accounting for motion-induced spatio-temporal variations in B-matrices and our proposed technique corrects most gradient-nonlinearity effects. |
| 1207
|
16:42
|
Motion-robust sub-millimeter isotropic diffusion imaging through Motion Corrected Generalized Slice Dithered Enhanced Resolution (MC-gSlider) acquisition |
1A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, 3Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, 4Graduate Program in Biophysics, Harvard University, Cambridge, MA, United States, 5Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States |
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gSlider is an SNR-efficient acquisition technique for high-resolution diffusion imaging (dMRI). However, subject motion is inevitable during long scans in high-resolution dMRI, leading to potential for artifacts and blurring. In this study, Motion Corrected gSlider (MC-gSlider) is proposed to obtain high-quality dMRI in the presence of large in-plane and through-plane motion, without use of a navigator. A motion-aware reconstruction with spatially-adaptive regularization is developed to achieve good reconstruction, even under difficult through-plane motions. MC-gSlider was demonstrated in-vivo to provide motion-robust, sub-millimeter isotropic dMRI with a motion correction rate of 2s, allowing for good reconstruction in the presence of large motions. |
| 1208 | 16:54
|
Higher order spherical harmonics reconstruction of fetal diffusion MRI with intensity correction |
1Biomedical Engineering, King's College London, London, United Kingdom, 2Perinatal Imaging and Health, King's College London, London, United Kingdom |
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We present a comprehensive method for reconstruction of fetal dMRI signal using a higher order spherical harmonics representation. We show that intensity correction improves the consistency of the volumetric reconstruction. By applying constrained spherical deconvolution and whole brain tractography to reconstructed fetal dMRI we are able to identify anatomically plausible fiber crossings. |
| 1209 | 17:06
|
Estimating susceptibility-induced field changes directly from diffusion MRI images and overcoming associated computational bottlenecks through GPU parallelisation |
1FMRIB, Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Centre for Medical Image Computing & Department of Computer Science, University College London, London, United Kingdom |
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We present a novel method (incorporated into FSL $$$\texttt{eddy}$$$) of estimating and correcting distortions due to dynamic changes in the susceptibility field when measuring diffusion using EPI. This method is able to track how the field changes with movement using only the diffusion data itself. We demonstrate an improvement in distortion correction, compared to using a static susceptibility field, for both simulated and actual data. Additionally, we demonstrate how computationally intensive portions of the estimation algorithm can be speeded up through GPU parallelisation. Reducing the runtime increases the likelihood of this method being widely adopted and broadens its impact potential. |
| 1210 | 17:18
|
In-Plane Superresolution with Phaseless Subpixel Encoding |
1Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland |
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A method to obtain a high-resolution 2D image from a series of subpixel-encoded low-resolution 2D scans is presented. The phaseless character of this encoding allows unknown signal phase fluctuations to be easily discarded and makes the method a promising alternative to k-space segmenting in motion-sensitive experiments such as diffusion MRI. Based on an analogy with the structured illumination method used in superresolution optics, important improvements have been introduced that reduce artefacts caused by k-space truncation and magnetic field inhomogeneity. The utility of the method is demonstrated by a 3-fold resolution enhancement of diffusion-weighted EPI of human head. |
| N03 | Thursday 15:30 - 17:30 | Moderators: Fernando Calamante & Baete Steven |
| 1211
|
15:30
|
Optogenetic fMRI dissection of brain-wide vestibular pathways |
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China |
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The vestibular system is essential to our sense of balance and spatial orientation. fMRI mapping of the vestibular system has been challenging due to the physical constraints limiting a subject’s ability to perform motion, balance and orientation related tasks within an MRI scanner. At present, our knowledge of the brain-wide cortical and subcortical regions that participate in processing the vestibular sense is scarce. Here, we combine fMRI and optogenetic stimulation of vestibular excitatory neurons and, for the first time, successfully map the multiple brain-wide vestibular pathways. |
| 1212 | 15:42
|
A novel approach for fMRI of rodents actively performing optogenetic self-stimulation |
1Neuroimaging Research Branch, National Institute on Drug Abuse, NIH, Baltimore, MD, United States, 2Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, NIH, Baltimore, MD, United States |
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Linking the dynamics of neural circuits to behavior is arguably a central theme in neuroscience. fMRI in rodent animals offers the opportunity to combine systems-level brain readout with modern in-vivo cell biology tools, such as DREADDS and optogenetics, to dissect circuit dynamics. Despite efforts to image awake rodents to avoid confounds from anesthesia, there has been no report on fMRI of rodent animals being actively engaged in a goal-directed behavior. We report a method that permits fMRI of brain dynamics while a mouse is actively self-administering optogenetic stimulation, opening the door to real-time imaging of animal behavior using MRI. |
| 1213
|
15:54
|
MouseStream: A Software Suite for Mapping and Analyzing Mouse Cortical Functional Architecture In Vivo Using Magnetic Resonance Microscopy |
1Department of Biomedical Engineering, Columbia University, New York, NY, United States, 2Departments of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, United States, 3Departments of Neurology, Radiology or Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, United States |
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The functional architecture of the cortex has never been mapped in vivo with the fidelity necessary to distinguish “functional unit”. Mapping the functional architecture of the cortex, reflecting the observed regional and layer differences in synaptic density and its correlate energy metabolism, has been very challenging. Here we set out to address this issue by in vivo high-resolution cerebral blood volume (CBV) mapping of the mouse cortex. Tailored software, MouseStream, was developed to reconstruct the cortical CBV data through the normalized curved cortical coordinate (NCCC). NCCC allows projection of functional architectures mapped using CBV onto the cortical surface across the whole cortex and from different cortical depths. |
| 1214 | 16:06
|
Longitudinal alterations of resting-state functional connectivity in Alzheimer’s disease in a tauopathy mouse model |
1ICube, University of Strasbourg, CNRS, Strasbourg, France, 2Faculty of Biology, University of Freiburg, Strasbourg, France, 3Dept. of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg im Breisgau, Germany, 4INCI University of Strasbourg, Strasbourg, France, 5LNCA, University of Strasbourg, Strasbourg, France, 6Centres Mémoire de Ressources et de Recherche, CHU de Strasbourg, Services Neurologiques et Gériatriques, Strasbourg, France, 7Département de Biophysique et Médecine Nucléaire, Hôpitaux Universitaires de Strasbourg, Strasbourg, France |
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Alzheimer’s disease is the most widespread cause of dementia and constitutes one of the biggest challenges for society. Among dominant mechanisms of the disease is the abnormal accumulation of the protein tau leading to tauopathy. In this study we explored in vivo the longitudinal evolution of the brain functional connectome, in the Thy-Tau22 mouse, a model of tauopathy. We used resting-state functional MRI in correlation with behavioral analysis to show the remodeling functional circuitry over-time including default mode network and memory networks in transgenic mice. |
| 1215 | 16:18
|
Brain perfusion patterns and their relationships with fMRI resting state networks and arterial vascular territories |
1Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy, 2Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy, 3Buffalo Neuroimaging Analysis Center, Department of Neurology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States, 4Università degli Studi di Milano, Milan, Italy, 5Radiology, Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy |
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In this study, we aimed to assess the consistency of the perfusion patterns that can be extracted using independent component analysis (ICA) on cerebral blood flow (CBF) maps derived from arterial spin labeling (ASL) data. Furthermore, we aimed to evaluate the similarity between the CBF-derived components and the well-known spatial patterns of functional MRI resting state networks (RSN) and cerebral vascular territories (VT). Our results showed that good spatial constancy of perfusion patterns can be extracted from CBF maps. Almost all the derived components overlapped with RSN or specific VT. |
| 1216
|
16:30
|
An approach to capture time-varying spatial connectivity in resting fMRI networks |
1The Mind Research Network, Albuquerque, NM, United States, 2Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, United States |
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The analysis of time-varying connectivity has become an important part of neuroscience discussions. The majority of such studies have focused primarily on the temporal variations of functional connectivity among fixed regions of interest (ROIs) or brain networks. However, the brain reorganizes itself on both spatial and temporal scales. Approaches that capture spatial and temporal coupling variations are needed. Here, we describe a novel approach capable of identifying the base states of brain networks and capturing their spatial variations over time. It also provides a unique opportunity to characterize the temporal variations of the brain at both network and global scales. |
| 1217 | 16:42
|
Physical Exercise Increased Involvement of Motor Networks as compensatory mechanism under challenging cognitive task |
1Departments of Psychiatry & Neuroscience, Yale University, New Haven, CT, United States, 2Olin Neuropsychiatry Research Center, Hartford Hospital/Institute of Living, Hartford, CT, United States, 3Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, 4Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, United States |
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Neuroimaging studies show reorganization of neural resources in older adults may compensate for cognitive decline. To effectively evaluate neural compensation, we proposed a data-driven independent component analysis method, and tested the measure through a longitudinal study. Twenty-six healthy older adults participated in a 6-week physical exercise program. Gait speed, cognitive function, and fMRI during a challenging memory task were measured before and after the program. Results showed a positive correlation between the compensatory ability measure and gait speed at baseline. Physical exercise improved gait speed, cognition, and compensatory ability through increased involvement of motor-related networks in conducting the cognitive task. |
| 1218
|
16:54
|
Are prediabetes and type 2 diabetes associated with white matter connectivity alterations? The Maastricht Study |
1Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 2Medicine, Maastricht University Medical Center, Maastricht, Netherlands |
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Type 2 diabetes (T2DM) is associated with cognitive decline, while prediabetes may already show comparable cognitive decrements. We investigated whether white matter network integrity is associated with prediabetes and/or T2DM in a large population-based cohort study. For calculation of white matter volumes and graph measures, 3T structural and diffusion MRI (dMRI) were performed. Prediabetes had lower clustering coefficient and local efficiency compared to NGM. Communicability was significantly higher in T2DM, but not in prediabetes, which suggests that alternative white matter connections are used to compensate for structural disturbances and white matter decline, which may not be present yet in prediabetes. |
| 1219 | 17:06
|
Exploring diffusion derived connectivity patterns between cognitively impaired and nonimpaired active professional fighters |
1Imaging, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States |
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In this study, we utilized the diffusion MRI ( |
| 1220 | 17:18
|
Longitudinal structural and functional brain network alterations in a mouse model of neuropathic pain |
1RG Translational Imaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany, 2Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany, 3RG Behavioral Genetics, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany, 4Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany, 5Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany |
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We combined multimodal (rsfMRI,M MRS, VBM) neuroimaging to longitudinally monitor changes in brain metabolism, structure and connectivity using the spared nerve injury (SNI) mouse model of chronic neuropathic pain. Voxel-based morphometry demonstrated volume decrease in all brain sites assessed. Global and local network changes after SNI disappeared over time, except the nucleus accumbens, prefrontal cortex and hippocampus. Connectivity changes were accompanied by enhanced glutamate levels in the hippocampus. We suggest that hippocampal hyperexcitability may alter synaptic plasticity within the nucleus accumbens, circadian motor activity and emotionality during pain chronification. |
| S03 | Thursday 15:30 - 17:30 | Moderators: Huijun Chen & David Saloner |
| 1221 | 15:30
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Advantages of Dual-Venc 4D flow MRI in the evaluation of cerebral aneurysms |
1Radiology, Northwestern University, Chicago, IL, United States, 2Neurological Surgery, Northwestern University, Chicago, IL, United States, 3Radiology and Neurological Surgery, Northwestern University, Chicago, IL, United States, 4Biomedical Engineering, Northwestern University, Evanston, IL, United States, 5Radiology, Neurological Surgery and Neurology, Northwestern University, Chicago, IL, United States |
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We applied and investigated the benefits of using kt-GRAPPA accelerated dual-venc 4D flow MRI in five patients who presented with cerebral aneurysm between 4 and 12mm (smallest and largest dimension). Velocity values were systematically compared with the high-venc-only part of the same acquisition using correlation and histogram analysis. Blood flow was visualized with streamlines and quality was visually assessed. Results show that dual-venc 4D flow MRI provides refined information on slow flow and recirculating flow in cerebral aneurysms. Future studies will assess the feasibility of advanced hemodynamic measures obtained from dual-venc 4D flow MRI as predictive imaging biomarkers. |
| 1222 | 15:42
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Evaluation of non-contrast enhanced 4-dimensional MRA with stack-of-stars golden angle radial trajectory in conjunction with KWIC reconstruction for the depiction of arteriovenous malformations |
1Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Beijing Tiantan Hospital, Beijing, China, 3Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 4School of Medicine, Shandong University, Jinan, China, 5Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, 6Neurosurgery, University of California Los Angeles, Los Angeles, CA, United States, 7University of Pennsylvania, Philadelphia, PA, United States |
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This study evaluated a recently developed non-contrast enhanced 4-dimensional MRA (NCE 4D MRA) with stack-of-stars golden-angle radial trajectory and KWIC reconstruction for the detection of cerebral arteriovenous malformation (AVM) by comparison with DSA, |
| 1223 | 15:54
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4D Flow assessment of arterial pulsation in the patients with internal carotid artery stenotic disease |
1Radiology, Nippon Medical School, Tokyo, Japan, 2Neurosurgery, Nippon Medical School, Tokyo, Japan, 3Radiology, Nihon University School of Medicine, Tokyo, Japan, 4Philips Electronics Japan, Tokyo, Japan |
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We performed 4D Flow MRI assessment of arterial pulsation in internal carotid artery stenotic disease (ICS) patients comparing to SPECT with acetazolamide challenge. Twelve patients with unilateral ICS were recruited. The blood flow volumes and the ratio of ΔF (rΔF) was calculated. In the affected-side MCA territory, the ratio of rest cerebral blood flow control (RCBFMCA) and cerebral vascular reserve (CVRMCA) were calculated from SPECT dataset. rΔF was significantly lower in the low CVR group than high group (P=0.008). The 6-min-standard 4D Flow MRI assessment of arterial pulsation in ICS patients can identify misery perfusion. |
| 1224 | 16:06
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In-vivo correlations between hemodynamics and wall inflammation in patients with intracranial aneurysms: comparing 4D Flow MRI and vessel wall enhancement. |
1Neuro-Radiology, Centre Hospitalier Sainte-Anne, Paris, France, 2department of medical physics, University of Wisconsin, Madison, WI, United States, 3department of Radiology, University of Wisconsin, Madison, WI, United States |
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Recent studies point out hemodynamics and wall inflammation as individual risk factors for aneurysm evolution. We investigated on 28 aneurysms in-vivo correlations between hemodynamics and wall inflammation by comparing 4D Flow parameters and quantitative aneurysm wall enhancement. Viscous energy loss and kinetic energy were correlated to maximum values of enhancement with high correlation coefficients (p<0.0001; correlation coefficient 0.79 and p<0.0001; correlation coefficient 0.85, respectively). By showing that flow instability and spatial flow complexity are highly correlated with aneurysm wall enhancement, this study highlights the existence of a link between inflammation process depicted through vessel wall enhancement and hemodynamic patterns. |
| 1225 | 16:18
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New 4D-MRA approach named 4D-APACK by integrating 4D-PACK and AccASL for visualization of long transit time artery: Investigating hemodynamics accuracy and AVM clinical case |
1Philips Japan, Shinagawa, Tokyo, Japan, 2Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 3Department of Radiology, Tokai University Hospital, Kanagawa, Japan, 4Philips Healthcare, Shinagawa, Tokyo, Japan |
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A new 4D-MRA approach named 4D-AccASL-PACK (4D-APACK) was implemented and images were acquired in six healthy volunteers and one AVM patient. 4D-APACK consists of 4D-PACK and acceleration-selective arterial spin labeling (AccASL) for obtaining efficiently both dynamic information and ATT independent visualization of very slow flow. 4D-APACK replaces last timepoint data of 4D-PACK with AccASL. To investigate hemodynamics accuracy for 4D-APACK, ATT correlation between 4D-pCASL and 4D-APACK and contamination of sinuses were measured. The vessel visualization of MCA M1 to M4 were compared with 4D-pCASL. We demonstrate that 4D-APACK brings reliable hemodynamic information comparable to 4D-pCASL, while retaining MCA visualization performance. |
| 1226 | 16:30
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Sing-vessel cerebral blood flow (velocity) fMRI with phase-contrast imaging |
1High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2University of Tuebingen, Tuebingen, Germany, 3Neurology, Renmin Hospital of Wuhan Universit, Wuhan University, Wuhan, China |
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Single-vessel fMRI has been developed to map the BOLD signal from individual venules and the CBV signal from individual arterioles penetrating the cortex of anesthetized rats. Here, we applied phase-contrast (PC) imaging to measure the velocity of blood flow from individual penetrating arterioles and venules, which could be characterized as dark and bright dots in an arteriole-venule map with a multi gradient-echo sequence. The neuronal activity-coupled cerebral blood flow (CBF) changes can be directly measured with the PC-based velocity mapping from individual vessels. Thus, we have established single-vessel CBF fMRI mapping with phase-contrast imaging. |
| 1227 | 16:42
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Sub-millimetric 4D Flow MR in small intracerebral aneurysms at 7 Tesla with experimental verification in upscaled 3D printed replica. |
1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2Department of Aerospace Engineering and Mechanics, University of Minnesota, Minneapolis, MN, United States, 3Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United States, 4Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, 5Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 6Department Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, United States, 7St. Anthony Falls Laboratory, University of Minnesota, Minneapolis, MN, United States, 8Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 9Department of Neurology, University of Minnesota, Minneapolis, MN, United States |
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Asymptomatic intracerebral aneurysms of small size (<7mm) pose a difficult therapeutic challenge: left alone they may stay stable with no consequence or they may grow and/or rupture with devastating subarachnoid hemorrages. Pre-emptive treatment (surgical or endovascular) however carries non-negligible mortality and morbidity and there is no biomarker predicting these relative risk. Flow dynamics inside small aneurysms however could have a critical impact on their evolution. Here we investigate the use of 4D Flow MR to acquire submillimitric flow information in small aneurysms in vivo as well as in 3D printed up-scaled replica of actual aneurysms measured in patients. |
| 1228 | 16:54
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Characterization of Ultra-short Echo and Standard echo Phase-Contrast MRI for Neurovascular disease application |
1Department of Physics, University of Wisconsin - Madison, Madison, WI, United States, 2Department of Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 3Department of Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, 4Department of Mechanical Engineering, University of Wisconsin - Madison, Madison, WI, United States, 5Department of Radiology, University of Wisconsin - Madison, Madison, WI, United States |
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We examined velocity measurements of standard (STD-PC) and ultra-short echo (UTE-PC) phase-contrast MRI in three different study cases, to characterize the effect of shortening echo time on artifacts from flow and metal. We found that UTE-PC measures higher velocity magnitudes not only in disturbed flow but also in normal vasculature, that UTE-PC results in smaller divergence of velocity field but no difference in erroneous flux through arterial wall within metal aneurysm stent, and that UTE-PC higher velocity magnitudes, less signal loss, and coherent flow directions in both untreated and un-treated aneurysm phantom. |
| 1229 | 17:06
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Intracranial flow measurements at 7T gated with Doppler Ultrasound |
1Lund University Bioimaging Center, Lund University, Lund, Sweden, 2Dept. of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 3nnorth medical Gmbh, Hamburg, Germany, 4Dept. of Diagnostic Radiology, Lund University, Lund, Sweden |
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Intracranial flow measurements at high field (7T) has the potential to give new information on hemodynamic properties. However, the strong field disturbs ECG gating, possibly compromising image quality. This work investigates possible benefits of using Doppler ultrasound (DUS) cardiac triggering compared to ECG–triggering in throughplane (2D) flow measurements at 7T. 2D flow was acquired using both ECG and DUS triggering in random order in healthy volunteers (n=8). The DUS was found to have a higher trigger sensitivity and fewer false negative and positive triggers. Flow and velocity results did not differ between ECG and DUS triggering. |
| 1230 | 17:18
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Scan parameter optimization of dual-venc 4D Flow MRI for the assessment of neurovascular flow networks in brain arteriovenous malformation |
1Biomedical Engineering, Northwestern University, Chicago, IL, United States, 2Radiology, Northwestern University, Chicago, IL, United States, 3Radiology, Neurosurgery, Northwestern University, Chicago, IL, United States, 4Neurointerventional radiology, Northwestern University, Chicago, IL, United States, 5Neurosurgery, Northwestern University, Chicago, IL, United States |
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To optimize dual-venc 4D Flow MRI parameters for flow assessment in brain arteriovenous malformations, we conducted an in-vitro optimization analysis and compared it to in-vivo data from a patient with complex AVM. Using k-t acceleration factors of 2-5 and about 2-10 voxels across the imaged vessels, we quantified the agreement with the ground truth flow and geometry. We applied a flow distribution network graph concept to characterize flow conservation as an additional quality metric. Data indicated that approximately 5 voxels across imaged vessels are needed, consistent with results from previous publications. |
| S04 | Thursday 15:30 - 17:30 | Moderators: Michaël Belloy & Sabrina Ronen |
| 1231 | 15:30
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A High Resolution Gradient-Echo/Spin-Echo EPI Sequence for Vessel Architecture Imaging |
1Department of Radiology, German Cancer Research Center, Heidelberg, Germany, 2Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany, 3Institute of Neuroscience and Medicine – 4, Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany, 4Department of Diagnostic & Interventional Radiology, German Cancer Research Center, Heidelberg, Germany, 5Department of Neurology, Faculty of Medicine, JARA, RWTH Aachen University, Aachen, Germany |
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To obtain vessel architectural imaging (VAI), a dual gradient-echo/spin-echo EPI sequence is needed to simultaneously track the dynamic signal changes in both gradient echo and spin echo contrasts. However, brain coverage and in-plane matrix size in previous brain studies were limited. In this study, the multiband excitation and blipped-CAIPI techniques were applied to improve the slice coverage. To enhance the in-plane resolution, two rephasing gradients were inserted after the GE readout, to return the data acquisition to the k-space center before the SE readout and enable parallel imaging techniques. |
| 1232 | 15:42
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Combined 18-FET-PET and diffusion kurtosis imaging study in treated glioblastoma patients: differentiation between metabolically active tumours and treatment-induced tissue abnormalities |
1Institute of Neuroscience and Medicine 4, Research Centre Juelich, Juelich, Germany, 2Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, 3Institute of Neuroscience and Medicine 3, Forschungszentrum Juelich, Jülich, Germany, 4Department of Neurology, University Hospital Cologne, Cologne, Germany, 5Center of Integrated Oncology (CIO), Universities of Cologne and Bonn, Cologne, Germany, 6JARA - BRAIN - Translational Medicine, RWTH Aachen University, Aachen, Germany |
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MRI and diffusion MRI techniques provide important diagnostic information regarding |
| 1233 | 15:54
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Moving Towards A DSC-MRI Consensus: A new single dose option for standardized rCBV. |
1Radiology, Medical College of Wisconsin, Milwaukee, WI, United States, 2Neurology, Medical College of Wisconsin, Milwaukee, WI, United States, 3Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States |
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DSC-MRI is the most common approach used for brain tumor perfusion imaging. Consensus is being reached regarding a recommended method for data acquisition, one that requires a contrast agent preload and the application of leakage correction. However, recent simulations suggest that if a low flip angle is used for DSC-MRI data collection then a contrast agent preload might not be necessary. In this study DSC-MRI data collected in 19 patients with brain tumors supports this hypothesis and further suggests that the application of leakage correction as well as a standardization algorithm further improves the results. |
| 1234
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16:06
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Multi-Parametric and Multi-Regional Histogram Analysis of MRI: Revealing Imaging Phenotypes of Glioblastoma Correlated with Patient Survival |
1Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, 2Department of Neurosurgery, Shanghai General Hospital, Shagnhai, China, 3Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 4NeuRoNeLab, DISA-MIS, University of Salerno, Salerno, Italy, 5Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom |
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Glioblastoma is characterized by its remarkable heterogeneity and dismal prognosis. Histogram features of MRI modality show potential in measuring the intratumoral heterogeneity. We integrate multi-parametric and multi-regional MRI histogram features to divide patients into groups and assess the relevance to treatment outcome. The results demonstrated that integrating multi-parametric and multi-regional MRI histogram features may help to stratify patients. The feature selected in this process also displayed prognostic values in the multivariate survival analysis. The histogram features selected from the proposed approach may be used as potential imaging markers in personalized treatment strategy and response determination. |
| 1235 | 16:18
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Supratentorial reorganization after treatment for childhood infratentorial tumors from a graph theoretical perspective |
1Pediatric Hemato-Oncology, UZ Leuven, Leuven, Belgium, 2Radiology, UZ Leuven, Leuven, Belgium, 3Perinatal Imaging & Health, King's College London, London, United Kingdom |
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In this study, structural brain topology was investigated in young adults who were treated for infratentorial tumors during childhood, using graph theory metrics based on whole-brain tractography. Comparisons with healthy controls yielded significant differences in global efficiency measures, independently from network density threshold. This cost-corrected measure was significantly related with IQ scores. By contrast, local efficiency and average nodal strength appeared different for core networks only. This finding suggests that connectivity of highly connected supratentorial hubs are predominantly affected following treatment for infratentorial tumours. |
| 1236 | 16:30
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Effect of Vascular Input Function Selection on Quantitative Dynamic Contrast-Enhanced MRI for Differentiating Pseudo-progression from True Progression in Glioblastomas |
1Radiology, Baylor College of Medicine, Houston, TX, United States, 2Diagnostic Radiology, MD Anderson, Houston, TX, United States, 3Imaging Physics, MD Anderson, Houston, TX, United States |
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Vascular input function (VIF) is a major source of error in the pharmacokinetic modeling of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) data. We investigated the influence of VIF variability on forward volumetric transfer constant, Ktrans, one of the kinetic parameters of DCE MRI. The diagnostic power of DCE MRI to discriminate between pseudo-progression and true progression of glioblastoma following chemoradiation therapy was determined by deriving Ktrans from five different VIF sources (population-based, middle cerebral artery, superior sagittal sinus—the latter two calculated by applying either an assumed or a measured T1) and using receiver operating curve analysis. |
| 1237 | 16:42
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Clinical predictors of serial changes in radiotherapy-induced microbleed burden and their relationship to white matter damage in 133 patients with glioma |
1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Radiology, University of California San Francisco, San Francisco, CA, United States, 3Neurology, University of California San Francisco, San Francisco, CA, United States, 4Neurological Surgery, University of California San Francisco, San Francisco, CA, United States |
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In the treatment of adult brain tumors, radiation therapy is associated with long-term effects including vascular injury in the form of cerebral microbleeds (CMBs), and white-matter changes. Ultra high-field MRI was used to detect CMBs, and predictors of CMB development were identified. Changes in individual and total CMB burden were characterized from serial imaging data with white-matter changes. Time since RT, multiple surgeries, tumor type and location were all predictors of development. The total number and volume of CMBs increased over time, while individual CMB size decreased and the surrounding white-matter showed signs of degradation. |
| 1238 | 16:54
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MRI Predictors of Response to Pembrolizumab, Bevacizumab and Hypofractionated Stereotactic Irradiation in Patients with Recurrent High Grade Gliomas |
1Cancer Imaging & Metabolism, Moffitt Cancer Center, Tampa, FL, United States, 2Cancer Imaging & Metabolism, Image Response Assessment Team Core, Moffitt Cancer Center, Tampa, FL, United States, 3Radiology, Moffitt Cancer Center, Tampa, FL, United States, 4Radiation Oncology, Moffitt Cancer Center, Tampa, FL, United States, 5Integrated Mathematical Oncology, Moffitt Cancer Center, Tampa, FL, United States, 6Neuro-Oncology, Moffitt Cancer Center, Tampa, FL, United States |
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Standard MRI scans of patients with recurrent |
| 1239 | 17:06
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Evaluating patients with Glioma using Multi-modal Hyperpolarized C-13 and H-1 Metabolic Imaging |
1University of California San Francisco, San Francisco, CA, United States, 2Chonam National University Medical School and Hospital, Chonam, Republic of Korea |
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Gliomas are heterogeneous and infiltrative brain tumors. Noninvasive evaluation of the extent and activity of tumor is important for making decisions about how to manage patients with glioma. In this study, we are examining the relationship between dynamic hyperpolarized C-13 data and H-1 MRSI parameters. Eleven patients with glioma were studied with both hyperpolarized [1-13C]pyruvate imaging and 3D H-1 lactate-edited MRSI. The H-1 data were affinely registered to the C-13 data, which allows voxel-by-voxel comparison. While these initial results indicate that there may be a trend towards an inverse relationship between C-13 lactate/pyruvate and steady state normalized lactate within the choline-to-NAA (CNI) lesion, further analysis is needed in a larger population of patients. |
| 1240 | 17:18
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Longitudinal Evaluation of Glioblastoma (GBM) Response to Chemo-radiation with Quantitative Magnetization Transfer (qMT) |
1Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 2Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 3Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada |
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Assessing |
| S05 | Thursday 15:30 - 17:30 | Moderators: Mikko Nissi |
| 1241
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15:30
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Simultaneous PET-MRI for Investigating Associations Between Bone and Cartilage Biomarkers of Knee Osteoarthritis |
1Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Physiology, Anatomy, Genetics, University of Oxford, Oxford, United Kingdom |
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Knee osteoarthritis (OA) is caused by cartilage degeneration which has been shown to be accompanied by the changes in adjacent subchondral bone. Simultaneous PET-MRI enables investigating the biomarkers of cartilage degeneration in OA with MRI (i.e. T1ρ, T2 and Gadolinium uptake) as well as biomarkers of bone remodeling in OA with PET (uptake of NaF tracer in bone) at the same time. PET-MRI also allows for probing the associations between different bone and cartilage markers. Voxel-wise assessment of these associations provides insight into the local correlations between different OA markers and yields comprehensive assessment of knee OA progression. |
| 1242 | 15:42
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Automated Textural Classification of Osteoarthritis Magnetic Resonance Images |
1Radiology, University of Cambridge, Cambridge, United Kingdom, 2Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, 3Mathematics, University of Cambridge, Cambridge, United Kingdom, 4Division of Trauma and Orthopaedic Surgery, University of Cambridge, Cambridge, United Kingdom |
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Osteoarthritis (OA) is the most common cause of disability in the United Kingdom and United States. Identifying the rate of OA progression remains an important clinical and research challenge for early disease monitoring. Texture analysis of tibial subchondral bone using magnetic resonance imaging (MRI) has demonstrated the ability to discriminate between different stages of OA. This work combines texture analysis with machine learning methods (Lasso, Decision Tree, and Neural Network) to predict radiographic disease progression over 3 years, trained using data from the Osteoarthritis Initiative. We achieved high sensitivity (86%), specificity (64%) and accuracy (74%) for predictions of OA progression. |
| 1243
|
15:54
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Anatomical variation of age-related changes in vertebral bone marrow composition using chemical shift encoding-based water-fat MRI |
1Department of Neuroradiology, Technical University of Munich, Munich, Germany, 2Department of Radiology, Technical University of Munich, Munich, Germany, 3Department of Nutritional Medicine, Technical University of Munich, Munich, Germany |
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The assessment of vertebral bone marrow water-fat composition is attracting growing interest for applications in osteoporosis and bone metabolism. Chemical shift encoding-based water-fat MRI allows spatially resolved assessment of proton density fat fraction (PDFF) at the spine. This study demonstrated that males started with greater PDFF values in the Twenties compared to females. However, females showed an accelerated bone marrow fatty conversion until the Seventies on. This finding can be explained by the (patho-)physiological process of menopause. Interestingly, the relative age-related PDFF changes from the Twenties to the Seventies were dependent on the anatomical location and were most pronounced at lower lumbar vertebral levels in both genders. |
| 1244
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16:06
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Unravelling bone marrow adipose tissue composition in proximal femur sub-regions through 3T Chemical Shift Encoded-MRI: differences between osteoporosis and glucocorticoid-induced osteoporosis |
1Department of Radiology, NYU Langone Health, New York, NY, United States, 2Université de Lyon; CREATIS CNRS UMR 5220, Inserm U1206, INSA-Lyon, UCBL Lyon 1, Villeurbanne, France, 3Department of Rheumatology, NYU Langone Health, New York, NY, United States, 4Radiology, NYU Langone Health, New York, NY, United States, 5Osteoporosis Center, Hospital for Joint Diseases, NYU Langone Health, New York, NY, United States |
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Osteoporosis (OP) is due to weak bone and can ultimately lead to fracture. Recent findings shows link between bone marrow adipose tissue (bMAT) composition and amount and OP. OP can be induced by drugs such as glucocorticoids resulting in glucocorticoid-induced osteoporosis (GIO) and can affect energy metabolism pathways, induce changes in bone including increased total marrow adiposity and changes in bMAT composition. The composition of bMAT in GIO has not been previously investigated. Our aim was to assess the bMAT composition of a GIO population and compare it to OP patients using 3T Chemical Shift Encoded- MRI (CSE-MRI). |
| 1245 | 16:18
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Quantitative Susceptibility Mapping of Human Spine: Correlation with Quantitative Computed Tomography and Reproducibility |
1Guangdong Provincial Key Laboratory of Medical Image Processing,School of Biomedical Engineering, Southern Medical University, Guangzhou, China, 2Philips Healthcare, Guangzhou, China, 3Department of Medical Imaging, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China |
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This work aim to investigate the correlation between quantitative susceptibility mapping (QSM) and quantitative computed tomography (QCT) values, and the reproducibility of QSM value in human spine. Sixty-one subjects underwent QCT measurement for once and QSM measurement for twice in spine. The results showed that QSM value has strong correlation with QCT value, and has good reproducibility between two scans. These indicated that QSM has the potential to be an effective and stable measurement of BMD in clinical application. |
| 1246 | 16:30
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Preliminary Application Researches of Quantitative Susceptibility Mapping in Evaluating the Osteoporosis |
1Department of Medical Radiology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China, 2School of Biomedical Engineering, Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China, 3Philips Healthcare, Guangzhou, China |
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The purpose of this work was to explore the clinical application of quantitative susceptibility mapping（QSM）using an ultrashort echo time (UTE) gradient echo (GRE) sequence in evaluating the bone mineral density（BMD）of lumbar vertebra by analyzing the correlation between QSM and quantitative computed tomography (QCT). Our results showed that there was strong correlation between QSM and QCT. QSM has the potential to be a biomarker providing new insights into osteoporosis. |
| 1247
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16:42
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In Vivo Bone 31P Relaxation Measurement and Its Implications on Mineral Quantification |
1University of Pennsylvania, Philadelphia, PA, United States |
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In MRI-based bone mineral assessment, pixel intensity of the bone is compared against that of the sample to estimate the 31P density after correcting for their relaxation properties. Knowledge of bone 31P relaxation times is therefore crucial. Using saturation-recovery spectroscopy and ZTE-PETRA, T1, T2* and density of bone 31P in healthy subjects (26 to 76 y/o) were measured yielding 36.8±1.4s, 196.9±10.1μs and 6.10±0.62 mol/L. Measured T1 and T2* errors are expected to be within 6% and 15%, resulting in an error of quantified [31P] of ≤ 6.3%. The small inter-subject variations may therefore obviate the need for individual T1 measurements. |
| 1248 | 16:54
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Zero TE Hip MRI: Osseous Measurements Assessing Femoroacetabular Impingement |
1Radiology and Imaging, Hospital for Special Surgery, New York, NY, United States, 2Sports Medicine, Hospital for Special Surgery, New York, NY, United States |
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Due to short tissue relaxation times and signal scarcity, routine MRI does not provide direct visualization of bone. This study investigates the use of proton density zero echo time (ZTE) MRI of bone in the hip, with emphasis on femoroacetabular impingement (FAI). Hip CT and ZTE images were acquired for 24 hips (14 patients). Ten measures of osseous morphology were compared between modalities. 'Moderate' to 'excellent' agreement was seen in all but one of the measurements. Zero Echo Time MRI may mitigate the need for CT in some cases. |
| 1249 | 17:06
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Three-Dimensional Ultrashort Echo Time Cones Actual Flip Angle Imaging with Variable Repetition Time (3D UTE-Cones AFI-VTR) for Accurate T1 mapping of Short T2 Tissues |
1University of California, San Diego, San Diego, CA, United States, 2GE Healthcare, San Diego, CA, United States, 3VA San Diego Healthcare System, San Diego, CA, United States |
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To overcome the challenges (i.e. fast signal decay and low excitation efficiency) which would other render T1 measurements inaccurate for short T2 tissues, we propose a new approach by combining 3D UTE-Cones the actual flip angle imaging (AFI) with UTE-Cones variable repetition time (VTR) (3D UTE-Cones-AFI-VTR) method, where the identical RF pulses and flip angles are used for signal excitation in both sequences. |
| 1250 | 17:18
|
CORTICAL BONE VESSEL IDENTIFICATION ON CONTRAST-ENHANCED MR IMAGES |
1Radiology and Biomedical Imaging, University of California - San Francisco, San francisco, CA, United States, 2School of Medicine, Radiology, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, United States |
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Pathological cortical bone porosity negatively impacts bone strength, but the mechanisms of pathological pore growth are not understood. We hypothesize that the contents of cortical bone pores (marrow or vessels) may be useful indicators of pore expansion mechanisms. In this study, we developed a technique using high resolution CT and DCE-MRI to visualize and identify pore contents. Dynamic features such as temporal intensity difference and transition slope within pore voxels were evaluated and clustered by a K-means clustering algorithm. The average intensity of segmented vessel-filled pores increased over time, demonstrating the ability of our technique to positively identify vessel-filled pores. |
| S06 | Thursday 15:30 - 17:30 | Moderators: Uwe Himmelreich & Tone Bathen |
| 1251
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15:30
|
ZTE MRI for attenuation correction in PET/MR: performance in a large cohort of cognitive disorder patients |
1Centre de NeuroImagerie de Recherche (CENIR), Institut du Cerveau et de la Moelle Epinière (ICM), Paris, France, 2Department of Nuclear Medicine, Groupe Hospitalier Pitié-Salpêtrière C. Foix, Paris, France, 3Laboratoire d’Imagerie Biomédicale, Sorbonne Universités, UPMC Univ Paris 06, Inserm U 1146, CNRS UMR 7371, Paris, France, 4Applications and Workflow, GE Healthcare, Orsay, France, 5Applications and Workflow, GE Healthcare, Cambridge, United Kingdom |
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Several attenuation correction (AC) methods based on Zero Echo Time (ZTE) MRI are available in brain PET/MR. However, most of them were evaluated in healthy subjects or in patients without apparent brain disease. In this work, we investigated ZTE-AC in a 50-patient cohort imaged for cognitive disorders and we compared its performance with default atlas-AC and reference CT-based AC. The impact of the two AC methods (ZTE-AC and atlas-AC) was evaluated and compared to reference CT-AC, using a Volume of Interest (VOI) analysis and voxelwise group comparison between patients with normal cortical metabolism vs. metabolic pattern suggestive of Alzheimer’s disease. |
| 1252 | 15:42
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UTE with Multi-Echo Radial Acquisition for PET/MRI Attenuation Correction |
1Engineering Physics, Tsinghua University, Beijing, China, 2Gordon Center for Medical Imaging, Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 3Nuclear Medicine, West China Hospital, Sichuan University, Sichuan, China, 4Key Laboratory of Particle and Radiation Imaging, Ministry of Education, Medical Physics and Engineering Institute, Tsinghua University, Beijing, China |
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Reliable estimation of PET attenuation coefficient (AC) is a fundamental problem in PET/MR imaging. Accurate measurement of bone density variation is vital to generate reliable subject-specific AC maps using MR. Also, minimizing the data acquisition time of MR sequences for AC is essential to allow more MR scans in a single PET/MR scanning session. In this work, we propose a new acquisition scheme combining UTE and multi-echo radial acquisition to reliably estimate the composition of water, |
| 1253 | 15:54
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Deep Learning based pseudo-CT computation and its application for PET/MR attenuation correction and MR-guided radiation therapy planning |
1GE Global Research, Bangalore, India, 2GE Healthcare, Munich, Germany, 3Umeå University, Umeå, Sweden, 4UCSF, San Fransisco, CA, United States |
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In this work, we demonstrate a generic deep learning (DL) model that computes pCT images (i.e. continuous density bone) using a single channel ZTE MRI data and is robust to protocol and coil variations (as dictated by application needs). The method was evaluated for PET/MR attenuation correction protocol (low resolution for speed) and MRgRTP dose planning protocol (higher resolution for spatial accuracy). The advantages include a single model for multiple protocols, pCT which are very much like real CT in appearance, as well as excellent quantitative accuracy of estimated bone values in the computed pCT. |
| 1254 | 16:06
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MR-Based Respiratory and Cardiac Motion Corrected PET/MR |
1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Department of Nuclear Medicine, European University of Brittany, Brest, France, 4British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom |
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A major advantage of hybrid PET/MR systems is the radiation-free high spatial and temporal resolution of MR imaging that can be used to estimate cardio-respiratory motion present during PET data acquisition. This information can be incorporated into reconstruction algorithms to correct for motion in the PET data to reduce blurring and increase target-to-background ratios (TBR) of PET hotspots. This may be of particular importance in cardiac imaging where the heart is in constant motion. In this work, we demonstrate a method for cardio-respiratory motion correction and evaluate the effect on TBR in the myocardium in a cohort of patients. |
| 1255
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16:18
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Simultaneous characterization of tumor cellularity and aerobic glycolysis with PET, MR and MRSI |
1Department of Nuclear Medicine, Technical University Munich, Klinikum rechts der Isar, Munich, Germany, 2Department of Chemistry, Technical University Munich, Garching, Germany, 3Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 4German Consortium for Translational Cancer Research (DKTK), Partnersite Freiburg, German Center for Cancer Research (DKFZ), Heidelberg, Germany, 5Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark, 6Department of Radiology, Technical University Munich, Klinikum rechts der Isar, Munich, Germany, 7Munich School of Bioengineering, Technical University Munich, Garching, Germany |
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The new paradigm in oncology to tailor patient-specific therapies triggered the invention of powerful imaging techniques to non-invasively quantify tumor biology in depth. PET/MR is an emerging new hybrid imaging modality that allows the simultaneous acquisition of high resolution anatomical, functional and metabolic information. We established a multimodal imaging workflow on a whole-body PET/MR system to quantify tumor cellularity, glucose uptake and aerobic glycolysis. We applied this workflow on a pre-clinical breast cancer model in a longitudinal study to analyze the effect of necrosis and tumor growth on metabolic parameters and measure the correlation of glucose uptake and LDH activity. |
| 1256 | 16:30
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Simultaneous PET and MRSI of Prostate Cancer |
1Department of Circulation and Medical Imaing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway, 2St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway, 3Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands |
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Both positron emission tomography (PET) and magnetic resonance spectroscopic imaging (MRSI) can give important information about cancer metabolism. With an integrated PET/MR scanner, MRSI and PET images can be acquired simultaneously. The aim of this study was to examine possible correlations between 18F-Fluciclovine PET and MRSI measurements and evaluate their diagnostic performance in prostate cancer. The results showed a significant moderate correlation between both SUVmean and SUVmax and the CCS/C ratio. A combination of the imaging outcomes derived from the integrated PET-MRSI modalities improved the localization accuracy of prostate cancer lesions. |
| 1257 | 16:42
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Comparison of Staging Capability among PET/MRI, MRI, PET/CT and Conventional Staging Method in Patients with Malignant Pleural Mesothelioma |
1Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan, 2Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Japan, 3Toshiba Medical Systems Corporation, Otawara, Japan, 4Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan, 5Center for Radiology and Radiation Oncology, Kobe University Hospital, Kobe, Japan |
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No direct comparisons for TNM staging capability among whole-body PET/CT, whole-body PET/ MRI, whole-body MRI and conventional radiological examination in malignant pleural mesothelioma (MPM). We hypothesize that whole-body FDG-PET/MRI and MRI have better potential for TNM stage assessment than whole-body FDG-PET/CT and conventional staging method in MPM patients. The purpose of this study was to directly and prospectively compare the TNM staging capability among whole-body FDG-PET/MRI, MRI with DWI, FDG-PET/CT and conventional staging method in MPM patients |
| 1258
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16:54
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Correlation between APT-CEST and 18F-Choline PET in glioma at 3T |
1Institute of Nuclear Medicine, UCLH, London, United Kingdom, 2Centre for Medical Imaging, UCL, london, United Kingdom, 3Medical school, UCL, london, United Kingdom, 4High Field Magnetic Resonance, Max Plank Institute, Tubinghen, Germany, 5Brain repair and Rehabilitation, UCL, London, United Kingdom, 6Teenage Cancer Unit, UCLH, london, United Kingdom |
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Chemical exchange saturation transfer MRI is emerging as a powerful diagnostic tool and has been shown to correlate with glioma tumour grade and molecular genetics. In this study, we aim to investigate whether APT signal is a non-invasive biomarker of Teenage and Young Adult glioma cell proliferation through correlation with 18F-Cho PET SUV as the gold standard. The strong positive correlation found in APT and 18F-Cho PET SUV indirectly demonstrates that APT SI may be a marker of glioma cell proliferation and further demonstrates the potential of APT in the assessment of glioma burden. |
| 1259 | 17:06
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Separating BOLD into local and non-local components using a novel simultaneous fMRI-fPET dual analysis |
1Monash Biomedical Imaging, Monash University, Melbourne, Australia, 2Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, Australia, 3Centre of Excellence for Integrative Brain Function, Australian Research Council, Melbourne, Australia, 4Department of Electrical and Computer Systems Engineering, Monash University, Melbourne, Australia |
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The objective was to separate the MRI BOLD response into local and non-local components using a simultaneously acquired functional FDG-PET (fPET) dataset. We used a visual task, with both high-frequency and low-frequency temporal components, to simultaneously evoke glucose and BOLD responses. Joint analysis of the fMRI and fPET identified two components, including a positively-correlated map of the visual cortex, and a negatively-correlated map of sub-regions of the visual cortex in fMRI and the draining vasculature in fPET. These findings provide preliminary evidence that we can deconstruct the fMRI BOLD signal into local (neuronal) and non-local (haemodynamic) components using simultaneous fMRI-fPET. |
| 1260 | 17:18
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Using Simultaneous PET/MRI and Cell Tracking to Evaluate Immunotherapies in Breast and Ovarian Cancer Models |
1Biomedical Translational Imaging Centre (BIOTIC), Halifax, NS, Canada, 2Dalhousie University, Halifax, NS, Canada, 3Immunovaccine Inc., Halifax, NS, Canada, 4Ottawa Hospital Research Institute, Ottawa, ON, Canada |
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Epithelial ovarian cancer and triple negative breast cancer (TNBC) are aggressive cancers with poor survival outcomes. Simultaneous FDG-PET/MRI and quantitative cell tracking were used to monitor orthotopic ovarian cancer and TNBC models for longitudinal tumor growth and metabolism in response to therapy while tracking immune cell subsets labeled with superparamagnetic iron oxide (SPIO). PET/MRI enabled monitoring of tumor growth and internal physiological changes and allowed quantitative assessment of tumor volumes over time. MRI cell tracking results indicated changes in the recruitment rates of three unique immune cell types over time in the group level with significant individual-level variability. |
| W05/06 | Thursday 15:30 - 17:30 | Moderators: Catherine Hines & Denis Le Bihan |
| 1261 | 15:30
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Assessment of Renal Fibrosis in a Rat Model of Unilateral Ureteral Obstruction with Diffusion Kurtosis Imaging: Comparison with α-SMA Expression and 18F-FDG PET |
1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China |
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To evaluate the value of diffusional kurtosis imaging (DKI) in renal fibrosis using a rat model of unilateral ureteral obstruction (UUO). Differences of DKI parameters among the time points and between the sides were compared. The correlation of DKI parameters with positron emission tomography (PET) renal function and expression of the fibrosis maker α-SMA were determined. There were significant differences on mean diffusivity (MD) and fractional anisotropy (FA) among days and between two sides. FA was moderate correlated with SUV and α-SMA. Therefore, quantitative DKI could be considered a useful and noninvasive method to help assess renal fibrosis. |
| 1262 | 15:42
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Applying T2 Relaxation Under Spin Tagging (TRUST) to assess renal oxygenation in the kidney |
1Sir Peter Mansfield Imaging Centre, The University of Nottingham, Nottingham, United Kingdom |
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T2 Relaxation Under Spin Tagging (TRUST) provides a method to measure oxygenation in venous vessels within the brain. Here, a TRUST scheme is adapted for use within the body, specifically to assess oxygenation in the renal vein, using a respiratory-triggered Flow-sensitive Alternating Inversion Recovery (FAIR) labelling technique. This FAIR-TRUST variant has been tested in the brain, its reproducibility assessed in the kidney, and used to measure a change in blood oxygenation during an oxygen challenge. Changes in renal vein oxygenation could be measured more robustly than changes in BOLD T2*, the current MRI standard tissue oxygenation assessment within the kidney. |
| 1263 | 15:54
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Principles for measuring whole kidney nephron endowment in mice with in vivo MRI |
1Physics, University of Hawaii at Manoa, HONOLULU, HI, United States, 2Pediatrics, University of Virginia, Charlottesville, VA, United States, 3Biology, University of Hawaii at Manoa, Honolulu, HI, United States |
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Nephron endowment is a strong predictor for renal health and nephron loss is a hallmark of early development of chronic kidney disease, but there are no techniques to measure nephron endowment in vivo. Here, we performed CFE-MRI in rats and mice to determine the limits of in vivo measurements of nephron endowment in vivo. We correlated in vivo measurements with measurements from ex vivo, high-resolution images of same kidneys. This work lays the foundation for consistent and accurate whole kidney glomerular number and size measurements in the mouse and rat kidney, in vivo. |
| 1264 | 16:06
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Multiphase Hepatocyte-Specific Contrast Enhanced MRI of Liver in a Non-Human Primate Model of Ebola |
1Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institute of Health, Frederick, MD, United States, 2Clinical Research Directorate/Clinical Monitoring Research Program, NCI Campus at Frederick, Leidos Biomedical Research, Inc., Frederick, MD, United States, 3Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institute of Health, Frederick, MD, United States |
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The purpose of this experiment was to assess the impact of Ebola virus infection on liver function during the acute phase of Ebola virus disease (EVD) in the rhesus macaque model in vivo imaging in a Biosafety level-4 facility. Multiphase liver-specific contrast, Eovist, enhanced MRI technique could detect the EVD liver failure. We observed a decreasing trend of Eovist uptake in the liver and biliary execution, and an increasing trend of liver volume with disease progression. Our findings highlight the spatiotemporal differences in Eovist uptake in a non-human primate model of Ebola. |
| 1265 | 16:18
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Comparison of long TE 1H-MRS to gas chromatography-mass spectrometry for analysis of adipose tissue fat composition |
1German Diabetes Center Düsseldorf, Düsseldorf, Germany |
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Long TE 1H-MRS of fat results in an improved baseline and more narrow peaks but may be impacted by J-coupling effects. Here we compare long TE 1H-MRS of adipose tissue fat composition to gas chromatography-mass spectrometry (GC-MS) of adipose tissue biopsies. There was a close correlation between the two methods for both unsaturation =CH/CH2 (R = 0.719, P < 0.00001) and saturated chain length CH2/CH3 (R = 0.782, P < 0.00001). MRS overestimated unsaturation and underestimated saturated chain length. Long TE 1H-MRS allows assessment of adipose tissue fat composition, however correction factors are needed for comparison to other methodologies. |
| 1266 | 16:30
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The presence of brown adipose tissue is associated with thyroid function in subjects with low and normal BMI |
1Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany, 2Else Kröner Fresenius Center for Nutritional Medicine, Technical University of Munich, Munich, Germany, 3Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, Munich, Germany, 4Philips Research Laboratory, Hamburg, Germany |
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Brown adipose tissue (BAT) is important for energy and glucose metabolism in humans. Thyroid hormones regulate BAT development and function. Proton density fat fraction (PDFF) mapping based on a multi-echo gradient echo acquisition enables spatially-resolved fat quantification and can be indicative of the presence of BAT in adults. This study investigates the relationship between supraclavicular PDFF as surrogate marker for BAT, and serum levels of free thyroxine and free triiodothyronine with body mass index (BMI) as grouping variable. |
| 1267 | 16:42
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Magnetic Resonance Imaging Based Assessment of High Fat Diet Induced Mitochondrial Dysfunction Mediated Impaired Lipid Oxidation in Brown Adipose Tissue: Novel Mechanistic Insights |
1Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore, 2Department of Physiology, National University of Singapore, Singapore, Singapore, 3Department of Radiology, Nationwide Children’s Hospital, Columbus, OH, United States |
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Understanding the functional aspects of BAT under obese and overweight conditions is important to improve metabolic dysfunction. Mechanisms that regulate the quality of BAT are influenced by dietary lipids and plays a vital role in fat oxidation. Our imaging and molecular biology data suggests that lipid oxidative capacity of the mitochondria in iBAT is compromised with increased accumulation of lipids. High fat dietary feeding did not affect the mitochondrial content. However, the mitochondrial function was profoundly impaired. The novel finding in this study is the reduction in the activity of complex II in HFD fed rats leading to mitochondrial dysfunction. |
| 1268 | 16:54
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Tongue deformation during mandibular advancement, as determined using tagged-MRI, may help to predict mandibular advancement treatment outcome in Obstructive sleep apnoea. |
1Neuroscience Research Australia, Sydney, Australia, 2School of Medical Sciences, University of New South Wales, Sydney, Australia, 3Prince of Wales Hospital, Sydney, Australia, 4Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, Australia, 5Charles Perkins Centre, University of Sydney, Sydney, Australia, 6Prince of Wales Clinical School, University of New South Wales, Sydney, Australia |
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Tongue deformation during mandibular advancement, as characterised by tagged-MRI, may be helpful to predict mandibular advancement splint (MAS) therapy for obstructive sleep apnea (OSA). 68 OSA patients untreated underwent a MRI scan prior to trialling a MAS and treatment outcome was determined. Preliminary results identified 3 possible tongue deformations (en bloc, oropharyngeal and minimal/backward) with variable impact on the upper airway size. Over all participants, tongue deformation was not associated with treatment outcome, but among obese participants, “en bloc” tongue deformation was associated with positive treatment outcomes. This may also improve the understanding of the mechanisms underpinning MAS therapy effectiveness. |
| 1269 | 17:06
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Non-invasive T1 mapping of the vitreous humour can detect central retinal vein occlusion and may discriminate between other forms of retinal ischaemia |
1Neuroscience, Brighton and Sussex Medical School, Brighton, United Kingdom, 2Sussex Eye Hospital, Brighton and Sussex University Hospital, Brighton, United Kingdom |
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In this work we demonstrate that careful T1 mapping of the vitreous humour can identify disease in the retina. We studied a cohort of patients with central vein retinal occlusion (a type of retinal ischaemia) and show that significant decreases in T1 of the vitreous humour are observed compared to healthy control eyes. We speculate that the decreases may be the result of increased pO2 that could arise when the oxygen demand of the retina is reduced as a consequence of damage. We show preliminary data from patients with proliferative diabetic retinopathy and ocular ischaemic syndrome that suggest that it may be possible to discriminate different forms of retinal ischaemia completely non-invasively with MRI. |
| 1270
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17:18
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Vagus Nerve Stimulation Promotes Gastric Emptying in Rat Measured by Magnetic Resonance Imaging |
1Electrical and Computer Engineering, Purdue University, West lafayette, IN, United States, 2Biomedical Engineering, Purdue University, West lafayette, IN, United States, 3Indiana University School of Medicine, Indianapolis, IN, United States, 4Psychological Sciences, Purdue University, West lafayette, IN, United States |
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We developed in vivo contrast-enhanced MRI and an image processing pipeline to image and assess the therapeutic effect of cervical vagus nerve stimulation (VNS) on gastric emptying and motility in rat. We found that: (1) VNS significantly promoted the rate of gastric emptying. (2) VNS significantly increased the degree to which the pyloric ring opened, and this outcome was correlated to the rate of gastric emptying. (3) The VNS parameters used in this study did not alter antral motility significantly. The proposed method allows non-invasive and repeated preclinical imaging of gastric physiology and diseases given electroceutical treatments. |
| W07 | Thursday 16:30 - 17:30 | (no CME credit) |
| Plenary Hall (Paris Room) | Thursday 17:45 - 18:45 |
| 17:45 | Young Investigator Awards Presentation |
| 17:50 | Closing Remarks |
| 18:45 | Adjournment |
| 18:45 | MRI in Yon Times of Yore |
| Les Pavillons de Bercy | Thursday 19:00 - 21:00 | (no CME credit) |