Synopsis

In recent years, with technology advancement and increasing availability of the high/ultrahigh field MR scanners, in vivo ¹⁷O MR spectroscopy & imaging has emerged as a valuable tool for noninvasively exploring metabolism in living organ or tissue because of the greatly improved ¹⁷O MR sensitivity at higher field. Quantifying regional cerebral metabolic rate of oxygen (CMRO₂) and its changes in animal or human brains may be the most important use of ¹⁷O MR. In this talk, I will present an overview of the ¹⁷O MRS/MRI technique, including the key aspects of the methodology and examples of potential applications.