BOLD Signal Physiology
Nicholas P Blockley1
1Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
Synopsis
To understand the strengths and limitations of functional MRI we must understand the interaction between the physiology of the brain and the physics of the measured signal. In this talk I will introduce the major physiological drivers of the Blood Oxygenation Level Dependent (BOLD) effect and describe how they affect the MRI signal. We can then use this knowledge to consider how stimulus evoked changes in the BOLD signal can be quantified as changes in oxygen metabolism. Whilst the BOLD signal is considered to be complex, through this understanding, we can observe it provides a rich source of physiological information.
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