Aiqi Sun1, Feng Huang1, Yu Wang1,2, Wei Xu1, Yiran Wang1, Hongyu Guo1, Yongsheng Chen3,4,5, and Ewart Mark Haccke2,3,5
1Neusoft Medical System, Shanghai, China, 2Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China, 3The MRI Institute for Biomedical Research, Detroit, MI, United States, 4Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang, China, 5Department of Radiology, School of Medicine, Wayne State University, Detroit, MI, United States
Synopsis
A technique named
Strategically Acquired Gradient Echo (STAGE) was recently published, which can
acquire 10 images with sufficient resolution, good SNR, and co-registration in
one 5-min scan on 3T. With an additional 4-min scan, MRAV and MRA can also be produced.
However, to acquire a full set of 12 images on 1.5T takes over 20 minutes,
which is still longer than clinical expectation. Novel acquisition and
reconstruction schemes are developed in this work to further reduce acquisition
time. Feasibility experiments demonstrate it is achievable to acquire 12 high
quality clinically meaningful images with 0.67×1.33×2.7 mm3 in 8
minutes on 1.5T.
Introduction
Multi-contrast brain
imaging is necessary for comprehensive diagnosis of cerebral disease. Conventional
individual acquisition scheme suffers from long scan time. To address this
issue, a technique called Strategically Acquired Gradient Echo (STAGE) 1, 2,
3 was recently published, which can
acquire 10 types of images with sufficient resolution, good SNR, and
co-registration in one 5-min scan on 3T. With an additional 4-min scan 3, MRAV and MRA can also be produced. Using the published protocol, the total acquisition time for the
full set of 12 images would be 9 min and 17 min on 3T and 1.5T separately. The purpose of this work is to
develop new acquisition and reconstruction schemes to further reduce the total acquisition
time. Feasibility experiments demonstrate that it
is achievable to acquire 12 high quality clinically meaningful images with 0.67×1.33×2.7
mm3 resolution in 8 minutes on 1.5T.Methods
Sequence Design To save acquisition time, two strategies are
used. First, the two separate acquisitions introduced in Ref [1] and Ref [3] are
combined to be one consecutive acquisition. Second, to accelerate acquisition
without degrading image quality much, a variable density (VD) sampling
strategy, as shown in Fig. 1, is adopted. In this strategy, the k-space is
divided into multiple regions, and the acceleration factors are increased from
the inside region out. The sampling density in each region keeps constant.
Data Acquisition and
Simulation Two healthy volunteers were scanned on a NMS
S15P 1.5T system (Neusoft Medical System, Shenyang, China) with an 8-channel
head coil (NMS, Shenyang, China). Eight sets of 3D axial images with fully
acquired k-space were collected in 21 min. Partially acquired data sets were simulated by dividing
the whole k-space into two regions with acceleration factor of 2 along L-R
direction for the central region and 4 for the outer region. Partial Fourier factor 80% was used along L-R
direction. The partial acquisition of net acceleration factor 2.78 simulated an
8-min acquisition.
Data Reconstruction A non-iterative VD SENSE 4 reconstruction
algorithm was developed, as shown in Fig. 1. The algorithm proposed in Ref [5] was
used for Partial Fourier reconstruction. The methods described in Ref [1, 2, 3] were
applied for post-processing with slight modification to take advantage of
8-echo for higher SNR.
Results
Based on the reconstruction from the partially
acquired 8-echo data set, twelve 3D brain images with
resolution 0.67×1.33×2.7 mm3 were derived, including T1w, PDw,
simulated FLAIR (sFLAIR), enhanced T1w (eT1w), SWI, true-SWI (tSWI), MRAV, MRA,
T1 map, PD map, R2* map and QSM. The results
of one subject are shown in Fig. 2. For better visualization, Fig. 3 provides
enlarged display for sFLAIR, eT1w, tSWI and QSM. Table 1 presents the comparisons
of the calculated T1 and R2* values respectively from the fully-sampled and simulated
partially acquired STAGE, and also with those in literature. The biases for
different regions between the accelerated STAGE and the fully-sampled one are all
within 5%. Discussion
As shown in Figs. 2 and
3, the images reconstructed with acceleration factor 2.78 have no visible
artifacts due to k-space undersampling. From Fig. 3, it can be clearly seen
that sFLAIR (Fig. 3a) and eT1w (Fig. 3b) images show excellent CNR, and the reconstructed
tSWI (Fig. 3c) can well characterize the structures with high susceptibility,
such as veins and globus pallidus. Furthermore, the generated QSM (Fig. 3d) also provides accurate basal
ganglia and veins. Table 1 demonstrates the partially acquired STAGE can derive
similar parametric values as the fully-sampled STAGE. There are two reasons
that the proposed method resulted in high image quality even if the
acceleration factor along one direction is as high as 2.78. First, with 8
echoes, there are more data for each calculated image, which is helpful for
higher SNR. Second, the VD acquisition scheme using low acceleration factor at
the central k-space protect the contrast and phase well, which is also important
for the calculations of SWI, QSM, and quantitative mapping. Different from the conventional
reconstruction methods for VD acquisition, the proposed non-iterative
reconstruction strategy is computationally efficient, which can be easily
applied to clinical practice.Conclusion
With the proposed acquisition and reconstruction method for
acceleration, we demonstrated the feasibility to acquire twelve 3D brain images
with high resolution, good SNR and co-registration in one single 8-min scan on
a 1.5T.Acknowledgements
No acknowledgement found.References
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