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| 1506 | Computer 41
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Demonstration of Intracranial Aneurysm Healing after Endovascular Coiling Evaluated by 3D T1 SPACE Magnetic Resonance |
| Sho-Jen Cheng1, Xue-Zhe Lu2, and Yi-Hsin Wang1 | ||
1Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan, 2Siemens Healthcare Limited, Taipei, Taiwan |
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Keywords: Vessel Wall, Vessels Angiography is a gold standard tool in the follow-up of the treated aneurysms to identify if there is aneurysm recanalization need further management. Despite non-invasive MR-based assessments be reported, the pathological changes of aneurysm on MRI was not clear. In this study, we employed three-dimensional variate flip angle MRI to evaluate the endothelial healing in ten cases with intracranial aneurysms after endovascular management. HRVWI routinely demonstrate the enhancement pattern of the aneurysmal neck not only the aneurysmal wall in both cross-sectional and time-serial follow up, increasing our confidence in making the decision whether to retreat or not. |
| 1507 | Computer 42
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Relationship beween Plaque burden, calcification features and low carotid stent expansion rate by high-resolution MR vessel wall imaging |
| Meng Yu Sun1, Wei Yu1, and Xiu Jian Lian2 | ||
1Radiology, Beijing Anzhen Hospital, BeiJing, China, 2Philips Healthcare, BeiJing, China |
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Keywords: Vessel Wall, Atherosclerosis To quantitatively evaluate carotid plaque burden and components and to explore the association between carotid plaque burden and compositions and carotid stent expansion rate (SER) by using carotid high-resolution magnetic resonance vessel wall imaging (HR-VWI). Maximum wall thickness (OR 1.75; 95% CI, 1.02-3.00, P=0.04), maximum single-slice calcification circumference score (OR 2.79, 95% CI 1.06 - 7.37, P=0.03), and maximum area percentage of calcification (OR 1.20, 95% CI 1.04 - 1.39, P=0.01) as predictors of the low SER. Larger culprit plaque, larger calcification area, and greater calcification circumference were independently associated with a low SER after carotid artery stenting. |
| 1508 | Computer 43
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Automatic segmentations for carotid vessel lumen and wall with arterial calcifications using spatially registered black- and gray-blood images |
| Bo Li1,2 | ||
1Center Laboratory, The Third Affiliated Hospital of Nanchang University, Nanchang, China, 2Radiology Department, The First Hospital of Nanchang City, Nanchang, China |
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Keywords: Vessel Wall, Segmentation We investigated automatic segmentations for the carotid vessel lumen and wall with the presence of arterial calcifications using spatially registered black- and gray-blood images. CS-siBLAG sequence was used to provide black- and gray-blood images. A K-means algorithm was employed to segment carotid artery lumen on black-blood images and calcifications on gray-blood images. A distance transform and an active contours model was used to segment the vessel wall. This method improves lumen segmentation, since it avoids the over-segmentation of vessel lumen by means of subtracting calcifications obtained on gray-blood images from the vessel lumen segmentation obtained on black-blood images. |
| 1509 | Computer 44
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Deep Learning-Based Automatic Segmentation of Arterial Plaques in MR Vessel Wall Images |
| Long Yang1,2, Xiong Yang3, Zhenhuan Gong3, Yufei Mao3, Guanxun Cheng4, Ke Wu3, Cheng Li3, Ye Li1, Dong Liang1, Xin Liu1, Hairong Zheng1, Zhanli Hu1, and Na Zhang1 | ||
1Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2School of Computer Sciences, University Sains Malaysia, Penang, Malaysia, 3Department of Image Advanced Analysis of HSW BU, Shanghai United Imaging Healthcare Co., Shanghai, China, 4Department of Radiology, Peking University Shenzhen Hospital, Shenzhen, China |
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Keywords: Vessel Wall, Atherosclerosis, atherosclerotic plaque, morphological quantitative assessment Manual segmentation of atherosclerotic plaque for quantitative assessment is a time-consuming process. In this study, a convolutional neural network based automatic segmentation method named Vessel-Segnet was proposed for quantitative evaluation of lumen, vessel wall and plaque based on MR vessel wall images. The proposed method achieved the best segmentation performance with the highest dice similarity coefficient and the lowest average surface distance among six models. In terms of morphological quantitative evaluation, the proposed method achieved excellent agreement with manual method. Overall, the proposed method can quickly and accurately realize the segmentation of lumen, vessel wall and plaque for quantitative evaluation. |
| 1510 | Computer 45
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The impact of intracranial atherosclerotic on the load and progress of cerebral small vessel disease |
| Lizhu yuerong1 | ||
1radiology, Beijing Chaoyang Hospital of Capital Medical University, Beijing, China |
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Keywords: Vessel Wall, Brain This study hypothesized that the load and the progression of cSVD in the unilateral hemisphere is correlated with the features of ipsilateral intracranial large arterial vessel wall lesions. Using the fluctuations of WHMs at baseline and follow-up to reflect the severity of cSVD. VW-HRMRI, the most sensitive non-invasive ways to evaluate the lesions of intracranial vascular, was used to assessment the morphological and enhancement characteristic of the culprit plaque. The result suggested that mild stenosis and positive remodeling of MCA may associated with WHM progression. |
| 1511 | Computer 46
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The risk prediction of ischemic stroke recurrence: a MR vessel wall imaging study |
| Fei Zhou1, Maoxue Wang1, Ruijing Xin1, Tianshu Yang2, Yongming Dai3, Na Zhang4, Zhanli Hu4, Xin Zhang1, and Bing Zhang1 | ||
1Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, 2Shenzhen United Imaging Research Institute of Innovative Medical Equipment, Shenzhen, China, 3MR Collaboration, Central Research Institute, United Imaging Healthcare, Shanghai, China, 4Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China |
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Keywords: Vessel Wall, Vessels Symptomatic cerebral vascular stenosis diseases include acute ischemic infarction and transient ischemic syndrome. Patients with these diseases often have a high risk of recurrence in the short term, which may have serious adverse consequences. High-resolution MR vessel wall imaging (HR-VWI) technique has provided new possibilities to assess the threat of stroke recurrence due to stenosis caused by intracranial plaque. The present study confirms that plaque morphological parameters obtained by HR-VWI can provide an effective prediction of stroke recurrence risk in patients with intracranial arterial stenosis. |
| 1512 | Computer 47
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Feasibility of Measuring Magnetic Resonance Elastography-derived Stiffness in Aortic Dissection |
| Adnan A. Hirad1, Faisal fakhouri2, Brian Raterman3, Dakota Gonring1, Arunark Kolipaka3, and Doran Mix1 | ||
1University of Rochester, Rochester, NY, United States, 2King Saud University, Riyadh, Saudi Arabia, 3The University of Ohio, Columbus, OH, United States |
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Keywords: Vessel Wall, Blood vessels Type-B aortic dissection represents a serious medical emergency with up to a 50% associated 5-year mortality caused by thoracic aorta, dissection-associated aneurysmal (DAA) degeneration, and rupture. Unfortunately, conventional diagnostic methods cannot distinguish high-risk DAAs that benefit from surgical intervention from stable DAAs. Our goal is to use DAA stiffness measured with magnetic resonance elastography (MRE) as a biomarker to distinguish high-risk DAAs from stable DAAs. This is a feasibility study using MRE to 1) measure stiffness in hydrogel phantoms with human-like dissection geometries and 2) demonstrate the first successful application of MRE to the thoracic aorta of a human volunteer. |
| 1513 | Computer 48
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Imaging Ascending Aortic Wall Stretch Using Breath-Held Displacement Encoding with Stimulated Echoes MRI: An Intra-scan Reproducibility Study |
| Huiming Dong1, Joseph Leach1, Ang Zhou1, Megan Ballweber1, Frederick H. Epstein2, Laing Ge3, Elaine Tseng3, David Saloner1, and Dimitrios Mitsouras1 | ||
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2University of Virginia, Charlottesville, VA, United States, 3Surgery, University of California, San Francisco, San Francisco, CA, United States |
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Keywords: Vessel Wall, Preclinical, Aortic Strain; DENSE MRI In vivo assessment of the mechanical properties of the aorta stands to offer valuable information to evaluate and predict the progression of cardiovascular diseases. Displacement encoding with stimulated echoes (DENSE) is a non-invasive phase-contrast MRI technique that has been adapted to measure ascending aortic wall stretch. Previous studies utilizing long respiratory-gated acquisitions are prone to artifacts from residual cardiac or respiratory motion. In this study, we investigated the reproducibility of a novel breath-held aortic DENSE imaging protocol. The proposed breath-held protocol was highly reproducible (COV=3.27% and LCCC=0.97). Finally, the measured aortic stretch followed the expected relationship with age. |
| 1514 | Computer 49
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High-resolution MR vessel wall imaging combined with Mediterranean diet adherence screener for evaluation of prognosis of ischemic stroke |
| Xiaochun Wang1 and Wenqiao Zheng1 | ||
1First Hospital of Shanxi Medical University, Taiyuan, China |
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Keywords: Atherosclerosis, Stroke To evaluate the prognosis of ischemic stroke (IS) by plaque characteristics based on high-resolution MR vessel wall imaging combined with Mediterranean diet adherence screener (MEDAS). IS patients were divided into two groups according to their prognosis. Clinical data and plaque characteristics were obtained and compared between groups. The correlation between these characteristics and prognosis was investigated by multivariate analysis. The ROC curves were further performed to determine their predictive performance. NIHSS score, MEDAS score, and plaque enhancement ratio were independent predictors of IS prognosis. Noteworthy, the combined model of three parameters showed significant superiority in the prognosis evaluation of IS. |
| 1515 | Computer 50
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Usefulness of Combined Evaluations of Coronary Calcification and Peripheral Nonenhanced MRA for the Risk Assessment of Future Vascular Events |
| Seigo Yoshida1, Katsumi Nakamura1, Akiyoshi Yamamoto1, Hidetoshi Akashi2, and Tetsuo Imamura3 | ||
1Radiology, Tobata Kyoritsu Hospital, Fukuoka, Japan, 2Vascular Surgery, Tobata Kyoritsu Hospital, Fukuoka, Japan, 3Surgery, Tobata Kyoritsu Hospital, Fukuoka, Japan |
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Keywords: Atherosclerosis, Cardiovascular Feasibility of a combined evaluation of coronary artery calcification by plain CT and severity of PAD assessed by nonenhanced MRA was evaluated for predicting the risk of future cerebrovascular and cardiovascular events. The result showed patients who had coronary calcium score of 1000 or higher and more advanced PAD were associated with 67% more subsequent cerebrovascular and cardiovascular events. The possibility of assessing these events in a noninvasive manner has been demonstrated, and early intervention may lead to improved patient outcomes. |
| 1516 | Computer 51
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Contrast-to-noise ratio of carotid artery perivascular adipose tissue on MRI: A potential indicator for carotid vulnerable plaque |
| Shuwan Yu1, Ran Huo2, Huiyu Qiao1, Zihan Ning1, Rui Shen1, Ning Xu1, and Xihai Zhao1 | ||
1Center for Biomedical Imaging Research, Tsinghua University, Beijing, China, 2Peking University Third Hospital, Beijing, China |
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Keywords: Atherosclerosis, Inflammation, Carotid artery PVAT, Vulnerable plaques Inflammation of carotid artery perivascular adipose tissue (PVAT) is associated with atherosclerotic disease. This study investigated the association between carotid artery PVAT and atherosclerotic plaques using multi-contrast MR vessel wall imaging. The contrast-to-noise ratio (CNR) of PVAT was measured on TOF MRA images. We found that the CNR of carotid artery PVAT measured by TOF MRA is independently associated with carotid vulnerable plaque features, suggesting that the CNR of PVAT might be a potential indicator for vulnerable atherosclerotic plaques. |
| 1517 | Computer 52
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Longitudinal study investigation of CMR measures and cardiac allograft vasculopathy over time |
| Sandra Quinn1, Chantelle Sanchez1, Ozden Kilinc1, Kai Lin1, Kambiz Ghafourian2, Daniel C Lee2, Esther E Vorovich2, Clyde W Yancy2, Vera H Rigolin2, Jon W Lomasney3, Bradley D Allen1, James C Carr1, and Michael Markl1 | ||
1Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 2Department of Medicine, Division of Cardiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 3Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States |
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Keywords: Myocardium, Transplantation, cardiac allograft vasculopathy CAV is a leading cause of mortality in HTx patients. Diagnosis and grading of CAV is dependent on repeated ICA which carries risk of major complications. CMR has the potential to be useful in CAV surveillance without the risk of ICA. This study has demonstrated that in a group of long-term heart transplant patients with evidence of CAV progression who undergo serial CMR and ICA within a close timeframe, 2D global peak strain parameters and 2D systolic strain rate correlates with CAV severity grade. FTS may therefore prove useful for surveillance of patients for CAV. |
| 1518 | Computer 53
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Multifunctional Nanoparticles for Detection and Treatment of Atherosclerotic Vulnerable Plaques |
| Man Ye1 | ||
1Renmin Hospital of Wuhan University, Wuhan, China |
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Keywords: Atherosclerosis, Molecular Imaging The instability of atherosclerotic plaque is seriously harmful to human health. The nanoparticle molecular probe we prepared can simultaneously achieve magnetic resonance and ultrasound imaging, which is expected to reflect the pathophysiological characteristics of plaque at the molecular level. The phase change induced by low intensity focused ultrasound (LIFU) can cause the apoptosis of macrophages in plaque，which has the potential for phase change ablation of plaque.1 It provides a simple, effective, safe and non-invasive new method for early diagnosis, treatment and efficacy monitoring of vulnerable plaque. |
| 1519 | Computer 54
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Diffusion Weighted-Viscosity Imaging for Atherosclerotic Plaques |
| Mayuka Seguchi1, Yuki Kanazawa1, Tosiaki Miyati2, Masafumi Harada1, Mitsuharu Miyoshi3, Yuki Matsumoto1, Hiroaki Hayashi2, Yasuhisa Kanematsu1, and Yasushi Takagi1 | ||
1Tokushima University, Tokushima, Japan, 2Kanazawa University, Kanazawa, Japan, 3GE Healthcare Japan, Hino, Japan |
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Keywords: Atherosclerosis, Diffusion/other diffusion imaging techniques We developed a Dw-viscosity imaging method to identify atherosclerotic plaques. First, we conducted experiments to determine ADC and viscosity changes of four different concentrations of glycerin solution, and determined the viscosity model. Second, a clinical study was carried out, and Dw-viscosity imaging was performed. As a result, we found that there was a significant difference between with and without hemorrhage findings (P < 0.01). Dw-viscosity imaging enables us to obtain more detailed information about atherosclerotic plaques such as intraplaque hemorrhage. |
| 1520 | Computer 55
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MR Feature Tracking-Derived Circumferential Strain of the Aortic Wall Correlates to Abdominal Aortic Aneurysm Growth Independent of Diameter |
| Huiming Dong1, Joseph Leach1, Ang Zhou1, Teodora Chitiboi2, Megan Ballweber1, Warren Gasper3, David Saloner1, and Dimitrios Mitsouras1 | ||
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Siemens Healthineers AG, Erlangen, Germany, 3Surgery, University of California, San Francisco, San Francisco, CA, United States |
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Keywords: Vessels, Vessels, Aortic Strain; MR Feature Tracking Recent studies are increasingly highlighting aortic wall stress, strain, and other mechanical descriptors as relevant factors associated with abdominal aortic aneurysm (AAA) progression. The goal of this prospective patient study was to employ MR feature tracking to measure the maximum circumferential strain in AAAs and study investigate its relationship with AAA growth. The feature tracking-measured AAA circumferential strain was lower than that of the normal aorta, indicating that the AAA wall is less compliant than the non-aneurysmal aorta. Furthermore, AAA strain was associated with the growth rate of the aneurysm, independent of AAA maximum diameter. |
| 1521 | Computer 56
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3D Isotropic black-blood cine MRI of intracranial arteries |
| Niranjan Balu1, Kaiyu Zhang2, Thomas S Hatsukami3, and Chun Yuan1,4 | ||
1Radiology, University of Washington, Seattle, WA, United States, 2Bioengineering, University of Washington, Seattle, WA, United States, 3Surgery, University of Washington, Seattle, WA, United States, 4University of Utah, Salt Lake City, UT, United States |
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Keywords: Vessels, Data Acquisition Pulsatile motion of intracranial arteries may provide useful diagnostic information of intracranial vascular pathology. We develop an isotropic 3D black-blood whole brain MRI method for assessment of intracranial vascular pulsation. Comparison of the black-blood with 2D bright-blood PC-MRA and assessment of luminal boundary changes across the cardiac cycle suggest that pulsation of large intracranial arteries can be detected and measured by black-blood cine MRI. |
| 1522 | Computer 57
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Three-dimensional Black-blood Thrombus Imaging (BTI) with LIBRE Fat suppression for the diagnosis of Deep Vein Thrombosis |
| Zeping Liu1, Zehe He2, Guoxi Xie1, Liping Liao2, Mingxia Tan2, Qizeng Ruan2, Lanbin Huang2, Qingchun Li2, Yuhui Nie1, Anyan Gu1, Zhuoneng Zhang1, and Yi Sun3 | ||
1Guangzhou Medical University, Guangzhou, China, 2The First People’s Hospital of Qinzhou, Qinzhou, China, 3Siemens Healthineers, Shanghai, China |
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Keywords: Vessels, Thrombo-Embolic Deep vein thrombosis (DVT) can lead to life-threatening pulmonary embolism. Black-blood thrombus imaging (BTI) technique can accurately identify DVT and provide additional information for thrombus staging. However, non-uniform fat suppression of BTI with conventional fat saturation preparation is obvious due to the field inhomogeneities and large field of view (FOV) imaging, which can affect the accuracy of detecting and staging of thrombus. To address this issue, a field inhomogeneity insensitive BTI technique was developed by incorporating LIBRE pulses for fat free and large FOV thrombus imaging. |
| 1523 | Computer 58
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Pathological changes of the coronary microvascular dysfunction pig models based on diffuse tensor imaging (DTI) |
| Zilong Ren1, Didi Wen2, Jianxiu Lian3, and Minwen Zheng4 | ||
1Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China, 2Department of Radiology, Xijing Hospital, Forth Military Medical University, Xi'an, China, 3Philips Healthcare China, Xi'an, China, 4Xijing Hospital, Fourth Military Medical University, Xi'an, China |
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Keywords: Heart, Animals To investigate whether diffuse tensor imaging (DTI) can be used as a predictor for coronary microvascular dysfunction (CMD). Pig models with CMD had higher mean diffusivity (MD), lower FA, and lower E2A compared with normal pigs (mean MDnormal = 1.50 ± 0.02, mean MDCMD = 1.65 ± 0.02, P = 0.001; mean FAnormal = 0.35 ± 0.01, mean FACMD = 0.27 ± 0.01, P < 0.001; mean E2Anormal = 53.33 ± 0.88, mean E2ACMD = 46.57 ± 1, P = 0.004). Cardiac DTI technology could add benefits of offering microstructure change and cardiac remodeling parameters for CMD pig models. |
| 1524 | Computer 59
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Association Between Epicardial Adipose Tissue volume and Microvascular Obstruction with ST-segment elevation myocardial infarction Patients |
| Dan Mu1, Xiuzheng Yue2, and Xiance Zhao2 | ||
1Department of Radiology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, nanjing, China, 2Philips Healthcare, Shanghai, China |
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Keywords: Atherosclerosis, Cardiovascular Epicardial adipose tissue (EAT) is a novel factor for risk stratification of coronary artery disease. EAT in microvascular obstruction formation in patients with ST-segment elevation myocardial infarction (STEMI) remain unclear. This study aimed to evaluate the correlation between EAT and MVO volume detected by CMR on a clinical 1.5T CMR system with a 28-channel coil array in STEMI patients. |
| 1525 | Computer 60
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Vertical Dynamic Pressure: a promising biomarker for describing inflammation in intracranial aneurysm |
| Haining Wei1, Mingzhu Fu1, Yudi Tang2, Peng Liu3, and Rui Li1 | ||
1Center for Biomedical Imaging Research, Tsinghua University, Beijing, China, 2Beijing Neurosurgical Institute, Capital Medical University, Beijing, China, 3Tiantan Hospital, Beijing, China |
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Keywords: Data Processing, Velocity & Flow, Intracranial Aneurysm Increasing histopathological evidence suggested that the inflammation processes and hemodynamics in vessel wall may mediate the growth and rupture of IA. For hemodynamics, previous studies reported that lower wall shear stress (WSS) is the most highlighted parameter associated with inflammation. Some studies also explored the dynamic pressure distribution at the sites of aneurysms based on computational fluid dynamics. Vertical dynamic pressure(VDP) can be seen as a possible measure for the force of the fluid impinging on the vessel wall. In this study, we propose to investigate the correlation of two hemodynamic parameters(WSS, VDP) with inflammation by advanced MRI techniques. |
| 1684 | WITHDRAWN |
| 1685 | Computer 41
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Whole-heart NCMRA Using Single-Breath-Hold TFE EPI at 3T:Comparison with 3D-mDixon TFE Coronary MRA on Healthy Volunteers |
| Mengyue Han1, Jian Wang1, Jian Yao1, Xiao Du1, Ruopeng Wang1, Tiantian Yang1, Zheng Jing1, Yingcui Zhu1, Baijie Li1, Chenglin Xu1, Deyue Yan1, and Xiuzheng Yue2 | ||
1Central Hospital Affiliated to Shandong First Medical University, Jinan, China, 2Philips Healthcare, Beijing, China |
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Keywords: Heart, Cardiovascular Non-contrast-enhanced whole-heart coronary MRA(NCMRA) is a noninvasive modality for the detection of coronary artery disease. 3D-mDixon with compressed SENSE has been used in clinical practices but was limited to its scanning time of approximately 5-15 minutes. The EPI technique could shorten the scan time in MRI acquisition. The study aimed to evaluate the image quality of single breath-hold TFE-EPI NCMRA and 3D-mDIXON NCMRA with compression SENSE in healthy volunteers. The results showed there was no significant difference in image contrast between the LM, RCA proximal, and LAD proximal. The single breath-hold TFE-EPI sequence might have its own unique advantages. |
| 1686 | Computer 42
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Contrast-enhanced MRA with GRASP outperforms the conventional TWIST in aortic dissection patient cohort |
| Camilla Giulia Calastra1, Fabian Haupt1, Elena Kleban1, Adrian Huber1, Daniel Becker 2, Hendrik von-Tengg Kobligk1, and Bernd Jung1 | ||
1DIPR (Department of Interventional and Pediatric Radiology), Inselspital, Bern, Switzerland, 2Department of Cardiovascular Surgery, Inselspital, Bern, Switzerland |
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Keywords: Vessels, Cardiovascular, Magnetic Resonance Angiography This work compares the application of two magnetic resonance angiography (MRA) sequences on an aortic dissection patient cohort: the conventional cartesian-sampling-based, TWIST sequence, and the new radial-sampling-based GRASP sequence. The 1.5T MRA data from six patients with aortic dissection were assessed qualitatively and quantitatively to investigate overall image quality and spatial and temporal blurring. GRASP outperformed TWIST in temporal SNR, vessel sharpness and reduction in image blurring; streaking artifacts were clearly visible, but did not affect the diagnostic image quality. |
| 1687 | Computer 43
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Simultaneous 3D Whole-Heart Bright-Blood and Black-Blood Imaging with iNAV-based Non-Rigid Motion-Corrected Reconstruction at 0.55T |
| Carlos Castillo-Passi1,2,3, Michael G. Crabb1, Camila Muñoz1, Donovan Tripp1, Karl P. Kunze1,4, Radhouene Neji 1,4, Pablo Irarrazaval2,3,5, Claudia Prieto1,3,5, and Rene M. Botnar1,2,3,5 | ||
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 3Millennium Institute for Intelligent Healthcare Engineering, Santiago, Chile, 4MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom, 5Electrical Engineering Department, Pontificia Universidad Católica de Chile, Santiago, Chile |
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Keywords: Heart, Low-Field MRI In this work, we demonstrate the feasibility of free-breathing whole-heart simultaneous bright-blood and black-blood imaging at 0.55T. We implemented an image navigator (iNAV)-based non-rigid motion-corrected 2 heartbeat sequence with 100% respiratory scan efficiency and high-dimensional patch-based low-rank (HD-PROST) denoising. The research sequence was validated on one healthy subject, showing simultaneous 3D visualization of cardiovascular anatomy on bright and black blood images at 0.55T in under 12 minutes scan time. |
| 1688 | Computer 44
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MRA for Pulmonary Embolism to Conserve Iodinated Contrast Media During an Acute Supply Chain-related Shortage |
| Jitka Starekova1, Sheena Y Chu1, David A Bluemke1,2, Thomas M Grist1,2,3, Joanna E Kusmirek1, Scott K Nagle1, Mark L Schiebler1, Meghan G Lubner1, Prashant Nagpal1, and Scott B Reeder1,2,3,4,5 | ||
1Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 3Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 4Medicine, University of Wisconsin-Madison, Madison, WI, United States, 5Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States |
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Keywords: Vessels, MR Value The closure of GE Healthcare’s Shanghai facility in April 2022 during the COVID-19 lockdown in China led to a major supply chain disruption of iodinated contrast media in North America. In response, our department instituted measures to conserve iodinated contrast, including the use of MRA as an alternative to contrast enhanced CTA to evaluate for pulmonary embolus (PE). Over the period of April through July of 2022, this strategy conserved an estimated 27 liters of iohexol 350 mg/ml. We report our experience on the use of MRA for diagnosis of PE in the general population during this period. |
| 1689 | Computer 45
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Ferumoxytol-Enhanced 5D ROCK-MUSIC with Low-rank Tensor Reconstruction: Initial Feasibility in Pediatric Congenital Heart Disease |
| Zixuan Zhao1, Hsu-Lei Lee2, Guowen Shao1, Zhengyang Ming1, Fei Han3, Dan Ruan1, Anthony Christodoulou2, J. Paul Finn1, and Kim-Lien Nguyen1,4 | ||
1University of California, Los Angeles, Los Angeles, CA, United States, 2Cedars-Sinai Medical Center, Los Angeles, CA, United States, 3Siemens Health Solutions, Los Angeles, CA, United States, 4VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States |
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Keywords: Heart, Cardiovascular, Congenital Heart Disease, Ferumoxytol ROCK-MUSIC is a 4D whole heart MRI pulse sequence that has shown promise for fast imaging in pediatric congenital heart disease (CHD) without dependence on the ventilator respiratory gating signal. Recent research in cardiac multitasking with low rank tensor (LRT) reconstruction allows for decomposition of cardiorespiratory motion. In this preliminary work, we showed that LRT reconstruction can be applied to the ROCK-MUSIC acquisition to enable higher temporal resolution with cardiorespiratory resolved imaging. When compared to L1-ESPIRiT, the LRT approach is able to achieve comparable image quality. |
| 1690 | Computer 46
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Deep Learning-Based Automatic Segmentation of Non-contrast Coronary Magnetic Resonance Angiography Images |
| Lu Lin1, Difei Jiang2, Yueting Xiao2, and Yining Wang1 | ||
1Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 2Shukun (Beijing) Technology Co., Ltd, Beijing, China |
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Keywords: Heart, Cardiovascular Coronary Magnetic Resonance Angiography (CMRA) is the only non-invasive coronary artery imaging method without radiation exposure and contrast media, and its application in clinical practice has been increasing. However, image post-processing for clinical diagnosis is time-consuming and requires expertise for radiologists. We proposed a three-dimensional U-Net-based automatic method for CMRA images by transfer learning from a pre-trained model of coronary computed tomography angiography(CCTA) to obtain accurate segmentation of coronary arteries. |
| 1691 | Computer 47
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Improved non-contrast-enhanced MR Venography of lower extremities using non-triggered 3D-GRE-EPI. |
| Toshiki Takumi1, Hiroshi Hamano1, Tomohiro Mochizuki1, Yasutomo Katsumata2, Masami Yoneyama1, Shouichi Andou3, Ken Ohno3, and Takashi Namiki1 | ||
1Philips Japan, Tokyo, Japan, 2Philips Healthcare, Tokyo, Japan, 3Kawanishi City Medical Center, Hyogo, Japan |
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Keywords: Vessels, Blood vessels, Venography MRI is one of a promising diagnostic of lower extremity arterial and venous disease, and non-contrast-enhanced MR angiography has an array of specific applications for numerous clinical indications. In this study, we demonstrated non-contrast-enhanced non-triggered 3D gradient-echo echo-planer-imaging (3D-GRE-EPI) can provide high quality MR Venography in lower extremities. Consequently, 3D-GRE-EPI was provided high sharpness, contrast and could distinguish veins and arteries. |
| 1692 | Computer 48
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Incorporation of View-Sharing and KWIC Filtering into XD-GRASP Reconstruction Improves Spatial Resolution in Thoracic NC-MRA |
| Lexiaozi Fan1,2, Jeanette N. Akuamoah2, Kyungpyo D Hong2, Joshua D. Robinson2,3,4, Cynthia K. Rigsby2,3,5, and Daniel Kim1,2 | ||
1Department of Biomedical Engineering, Northwestern University, Evanston, IL, United States, 2Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, 3Department of Pediatric, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, 4Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States, 5Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States |
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Keywords: Vessels, Image Reconstruction Conventional thoracic non-contrast magnetic resonance angiography (NC-MRA) often produces suboptimal image quality in pediatric patients with congenital heart disease (CHD) and results in lengthy scan times. We recently developed a NC-MRA pulse sequence using a stack-of-stars k-space sampling pattern with XD-GRASP reconstruction and evaluated its performance in adults. In this study, we sought to improve our NC-MRA pulse sequence by incorporating view-sharing (VS) and k-space weighted image contrast (KWIC) filtering to reduce blurring, which is critical for pediatric patients who have smaller hearts and faster heart rates than adults. We evaluated it performance against contrast-enhanced MRA in pediatric patients. |
| 1693 | Computer 49
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Acceleration of brain MRA with Spiral, compared with Compressed SENSE |
| Yujie Yu1, Maoxue Wang1, Xiance Zhao2, and Weibo Chen2 | ||
1The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, 2Philips Healthcare, Shanghai, China |
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Keywords: Vessels, Brain, TOF The purpose of this study is to quantitively and qualitatively evaluate the clinical feasibility of spiral-based TOF-MRA (MRAspiral) in terms of acceleration of data acquisition and imaging performance, with reference to the routine use of TOF-MRA with C-SENSE=4. The results showed that MRAspiral with τ=8 (2min7s) can significantly reduce the acquisition time by 44.3% with a balanced image quality and scan time for arteries visualization and clinical diagnosis. |
| 1694 | Computer 50
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Efficiency of 3D ky-kz centric acquisition in whole heart coronary MRA (WHCA) using high resolution deep learning reconstruction (HR-DLR) |
| Yoshiaki Morita1,2, Hideki Ota2, Takashi Nishina3, Sho Tanaka3, Yuichi Yamashita3, Yoshimori Kassai3, Ryuichi Mori2, Yuki Ichinoseki2, Tatsuo Nagasaka2, Mitsue Miyazaki4, Kei Takase2, and Tetsuya Fukuda1 | ||
1Department of Radiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan, 2Department of Radiology, Tohoku University Hospital, Sendai, Japan, 3Canon Medical Systems Corporation, Otawara, Japan, 4Department of Radiology, University of California, San Diego, La Jolla, CA, United States |
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Keywords: Heart, Cardiovascular, coronary artery Whole heart coronary MRA (WHCA) using fast field echo (FFE) with 3D centric ky-kz trajectory was compared with conventional FFE on healthy subjects. The mean acquisition was almost within 5 minutes using a 30-mm threshold in real-time motion correction with a navigator echoes. High resolution deep learning reconstruction (HR-DLR) was also applied to improve the image quality. |
| 1695 | Computer 51
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Native MR angiography of the thorax using Compressed Sensing and 1-point Dixon at 3T: Comparison with standard fat suppression and 2-point Dixon |
| Michaela Schmidt1, Marcel Dominik Nickel1, and Daniel Giese1 | ||
1Siemens Healthcare, Erlangen, Germany |
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Keywords: Vessels, Blood vessels For increased vessel contrast a robust fat suppression of adjacent fat is desirable in MR angiography. While spectral fat suppression can be insufficient, fat separation based on 2-point Dixon requires the acquisition of a second echo. A 1-point Dixon approach based on opposed-phase imaging is presented here that allows to suppress fat dominated voxels effectively while keeping scan efficiency. The approach is evaluated in volunteers and compared to conventional approaches regarding image quality, artifacts, fat suppression and vessel diameter. |
| 1696 | Computer 52
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Cardiac Gated, Ferumoxytol-Enhanced MR Angiography of the Aorta with a Flexible k-space Trajectory: Initial Results |
| J Paul Finn1,2,3, Takegawa Yoshida1,2, Arash Bedayat1,2, Kim-Lien Nguyen2,3,4, Xiaodong Zhong5, and Gerhard Laub6 | ||
1Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, Los Angeles, CA, United States, 2Diagnostic Cardiovascular Imaging Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, Los Angeles, CA, United States, 3Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, Los Angeles, CA, United States, 4Division of Cardiology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States, Los Angeles, CA, United States, 5Siemens Healthineers, Los Angeles, CA, United States, 6DrLaubconsulting LLC, Los Angeles, CA, United States |
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Keywords: Heart, Cardiovascular Contrast enhanced MRA of the aorta is typically performed without cardiac gating, greatly limiting its value in the aortic root and its more widespread utilization. We implemented a cardiac gated sequence for breath-held MRA of the thoracic aorta with flexible contrast during the steady-state distribution of ferumoxytol and compared it to ungated MRA with similar resolution. The resulting images were compared for definition of the aortic annulus, leaflets and ascending aorta. The gated sequence performed significantly better than the ungated sequence for all measured parameters and holds promise as a high quality alternative to gated CTA in appropriate clinical circumstances. |
| 1697 | Computer 53
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Non-Contrast Carotid Artery Imaging using 3D TOF and Time-SLIP bSSFP with centric ky-kz k-space trajectory. |
| Vadim Malis1, Won Bae1,2, Yoshimori Kassai3, Marin A Mcdonald1, and Mitsue Miyazaki1 | ||
1Radiology, UC San Diego, San Diego, CA, United States, 2VA San Diego Healthcare System, San Diego, CA, United States, 3Canon Medical, Ōtawara-shi, Japan |
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Keywords: Vessels, Vessels, Non-Contrast MRA Carotid artery stenosis (CAS) is one of the most common causes of acute ischemic stroke. MRA techniques are routinely used for the diagnostics of CAS, yet one of their drawbacks remains as a long scanning time. In this study we acquired and compared two sets of images of carotid arteries: 3D time-of-flight (TOF), time spatial labeling inversion pulse (Time-SLIP) balanced steady-state free precession (bSSFP) and their accelerated versions that utilize centric ky-kz acquisition pattern (FAST3D). |
| 1698 | Computer 54
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Application of 4D-PACK and 4D-S-PACK in the internal carotid artery occlusion: initial experience |
| Jin Zhang1, Beibei Sun2, Shenghao Ding2, Yongjun Cheng3, Mengyou Ma3, Xinyang Wu3, Peng Wu3, and Huilin Zhao2 | ||
1Radiology, Renji hospital, Shanghai, China, 2Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China, 3Philips Healthcare, Shanghai, China |
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Keywords: Vessels, Blood vessels We recruited 4 patients with internal carotid artery occlusive diseases and assessed whether 4D-MR angiography can be used as a noninvasive alternative to intraarterial DSA. All patients were imaged with TOF-MRA, 4D-PACK, 4D-S-PACK, and DSA. 4D-PACK demonstrated a sensitivity, specificity, and accuracy of 100%, 100%, and 100% respectively, as same as TOF-MRA, for diagnosing ICAO in reference to DSA. Moreover, 4D-PACK along with 4D-S-PACK could provide additional dynamic information on compensatory circulation after ICAO. Our results showed that non-contrast 4D-MR angiography has the potential to become an alternative imaging approach in diagnosing ICAO and initially assessing its blood supply pattern. |
| 1699 | Computer 55
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High-Resolution Heart-Saturated TOF (HRHS-TOF): A novel MRI protocol for atherosclerotic plaque imaging on mice in vivo |
| Nan Gao1, Yuqing Wang1, Chengqin He2, and Xiaolei Song1 | ||
1Center for Biomedical Imaging Research, Tsinghua University, Beijing, China, 2Inno Medicine, Beijing, China |
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Keywords: Atherosclerosis, Atherosclerosis Time of flight (TOF) is the most commonly used bright blood MRI method for imaging the human vascular system. However, there were several challenges when TOF was used for imaging AS plaque in mice. This study proposed a novel MRI protocol, High-Resolution Heart-Saturated TOF (HRHS-TOF), imaging only AS plaque without background information. Moreover, this protocol could perform without measurement of the T1 value of blood in advance. ApoE−/− mice were scanned to investigate the feasibility and data interpretation of HRHS-TOF protocol. |
| 1700 | Computer 56
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Analysis of baseline and cardiac function factors affecting the image quality of contrast-free 3.0T MR coronary angiography |
| Gang Zhang1, Wei Xing1, Zhiwei Shen2, Jianxiu Lian2, and Ke Jiang2 | ||
1The First Affiliated Hospital of Henan University of CM, Henan, China, 2Philips Healthcare, Beijing, China |
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Keywords: Heart, Cardiovascular Magnetic resonance coronary angiography (MRCA) imaging technology is still somewhat sophisticated, with numerous elements influencing image quality. This study found that for subjects with high BMI, high heart rate, and high systolic blood pressure, further optimization of imaging sequences and parameters is needed to explore individualized coronary MR imaging protocols. |
| 1701 | Computer 57
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Magnetic resonance imaging of fetal aorta |
| LIN GANG1 | ||
1Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi, China |
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Keywords: Vessels, Cardiovascular Key words：fetal cardiovascular; coarctation of aortic arch;imaging technology Prenatal ultrasound diagnosis has always been the first choice of screening for perinatal birth defects. However, due to the influence of many factors, the difficulty of diagnosis is increased, even for experienced experts, so there is an urgent need to find better supplements and alternatives. With the development of the treatment of cardiovascular diseases, many congenital aortic diseases can be alleviated or cured by perinatal surgery or elective surgery, so early diagnosis can reduce perinatal morbidity and mortality.the author has made some innovative explorations in the MRI scanning method of fetal cardiovascular. |
| 1702 | Computer 58
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Breath-hold Whole Heart Coronary MRA with Parallel Imaging, Compressed Sensing and Deep Learning reconstruction |
| Mitsuharu Miyoshi1, Atsushi Nozaki1, Shigeo Okuda2, Masahiro Jinzaki2, and Tetsuya Wakayama1 | ||
1Global MR application and workflow, GE Healthcare Japan, Tokyo, Japan, 2Department of Radiology, Keio University School of Medicine, Tokyo, Japan |
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Keywords: Heart, Cardiovascular, Coronary Artery For Breath-hold Whole Heart Coronary MRA, we developed the combination of Parallel Imaging and Compressed Sensing to accelerate scan time and Deep Learning reconstruction to improve the image quality. With the combination of these techniques, we could obtain Coronary MRA with 1.8mm isotropic acquisition voxel size in a possible breath-hold scan time. Deep Learning recon effectively improved the SNR and image quality. |
| 3644 | Computer 61
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Optimal encoding strategies for turbulence quantification of undersampled 4D flow MRI |
| Pietro Dirix1, Stefano Buoso1, and Sebastian Kozerke1 | ||
1University and ETH Zurich, Zürich, Switzerland |
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Keywords: Flow, Image Reconstruction We expand a previously developed pipeline for generation of synthetic 4D flow MRI of turbulent flows to account for realistic k-space filling and add an MR temporal averaging component to the simulations. We show that temporal averaging in typical undersampled 4D flow MRI is imperfect, leading to inherent scan-to-scan variations of measured turbulence fields. We demonstrate how encoding schemes, when designed appropriately, allow to significantly reduce scan-to-scan variability, increasing the confidence on MRI measurements. |
| 3645 | Computer 62
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TKE-Net: Deep Learning for Estimation of Super-Resolved Turbulent Kinetic Energy Maps from 4D-Flow MRI Data |
| Amirkhosro Kazemi1, Marcus Stoddard1, and Amir A. Amini1 | ||
1Electrical and Computer Engineering, University of Louisville, Louisville, KY, United States |
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Keywords: Phantoms, Heart, Hemodynamics, Flow, Neural network, Deep learning Variations in velocity derivative fluctuations have been correlated with changes in pressure gradient. Image denoising and super-resolution techniques are required to accurately quantify velocity fluctuations. We propose a novel network, which we call TKE-Net to estimate Turbulent Kinetic Energy (TKE) which utilizes a ResNet convolutional neural network backbone. The network is trained and tested with low-resolution simulated CFD data, as could be derived from low resolution 4D flow in a phantom model of arterial stenosis. The results indicate good accuracy in estimating TKE. The method was also applied to in-vitro 4D flow MRI data in identical geometry. |
| 3646 | Computer 63
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On the interplay of encoding and readout in turbulent flow imaging |
| Charles McGrath1, Pietro Dirix1, Jonathan Weine1, and Sebastian Kozerke1 | ||
1University and ETH Zurich, Zurich, Switzerland |
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Keywords: Flow, Velocity & Flow, Turbulence The accuracy of turbulent flow quantification using phase-contrast MRI depends on both the turbulence energy spectrum to be imaged and the sampling spectrum of the velocity encoding gradients. In the present work their interplay is studied in detail, revealing erroneous quantification of intravoxel standard deviation and turbulent kinetic energy in particular in cases exhibiting low turbulence frequencies. It is concluded that experimental design for turbulent flow quantification needs to consider the joint effect of velocity encoding and imaging gradients. Keywords: Turbulence, TKE, Phase Constrast, Simulation, Flow, Cardiovascular |
| 3647 | Computer 64
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In-Plane Balanced Phase-Contrast Steady-State Free Precession (PC-SSFP) for All-in-One Diastolic Function Evaluation |
| Jie Xiang1, Jerome Lamy2, Maolin Qiu2, and Dana C. Peters1,2 | ||
1Department of Biomedical Engineering, Yale University, New Haven, CT, United States, 2Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States |
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Keywords: Flow, Quantitative Imaging Diastolic function evaluation requires estimates of early and late diastolic mitral valve flow velocities (E and A), and mitral annulus tissue velocity (e’). Our goal was to develop a bSSFP phase-contrast (PC) sequence (PC-SSFP) for in-plane flow-encoding, for simultaneous recording of E and A, and estimation of e’ based on tracking mitral valve motion on cine magnitude images, in a single breath-hold. Phantom and in vivo experiments showed agreement of PC-SSFP with velocities on GRE-based PC providing similar velocity curves, while achieving the high SNR and contrast of bSSFP cine images. |
| 3648 | Computer 65
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Denoising Vastly Undersampled Radial Portal Venous 4D Flow Data via Deep Learning |
| Tarun Naren1, Oliver Wieben1,2, Thekla H Oechtering2,3, Scott B Reeder1,2, and Kevin M Johnson1,2 | ||
1Department of Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 2Department of Radiology, University of Wisconsin - Madison, Madison, WI, United States, 3Department of Radiology, Universität zu Lübeck, Lübeck, Germany |
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Keywords: Flow, Liver Radially undersampled 4D flow MRI is a promising method for non-invasive mapping of blood flow in the portal venous system. However, collecting sufficient projections to produce clinically viable images can lead to long scan times (10+ minutes) as fewer projections cause undersampling artifacts that appear as structured noise. In this study, we propose a data-driven, deep learning method to denoise vastly undersampled (<10% of full Nyquist sampling) radial 4D flow MRI data in the portal vein. We train a network on a heterogeneous, time-averaged dataset with two levels of undersampling and perform a quantitative hemodynamic analysis to compare results. |
| 3649 | Computer 66
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Prediction of Eddy Current-Induced Background Phase Offsets in 2D Phase Contrast-MRI |
| Julio A. Oscanoa1,2, Matthew J. Middione2, Michael Loecher2, Ana Beatriz Solana3, Shreyas S. Vasanawala2, and Daniel B. Ennis2 | ||
1Department of Bioengineering, Stanford University, Stanford, CA, United States, 2Department of Radiology, Stanford University, Stanford, CA, United States, 3GE Healthcare, Munich, Germany |
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Keywords: Flow, System Imperfections: Measurement & Correction, Phase-Contrast, Eddy currents We propose a physics-driven approach for prediction of eddy current-induced background phase offsets in 2D PC-MRI. The method leverages the applied gradient waveforms and a circuit model to estimate the system-dependent parameters that govern the background phase. The aim is to use these parameters and the model to predict the background phase of clinical acquisitions from pulse sequence information only. Our method achieved an RMSE of 1.05 cm/s and adequate visual quality. |
| 3650 | Computer 67
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Deep learning-based prediction of aortic hemodynamics obtained by 4D flow MRI using seismocardiography of chest vibrations |
| Mahmoud Ebrahimkhani1, Ethan Johnson1, Aparna Sodhi2, Joshua Robinson2,3, Cynthia Rigsby2, Bradly Allen3, and Michael Markl3 | ||
1Radiology, Northwestern University, Chicago, IL, United States, 2Ann & Robert H. Lurie Children’s Hospital, Chicago, IL, United States, 3Northwestern University, Chicago, IL, United States |
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Keywords: Flow, Heart We pursued a deep learning approach to investigate the utilization of a wearable seismocardiography (SCG) device to predict measures of flow similar to those obtained using 4D flow MRI. SCG can measure the chest vibrations caused by cardiac mechanical activities such as valve closures and changes of pulsatile flow. We hypothesized that deep learning can be used to infer the pathological changes in blood flow, such as a higher systolic peak velocity (Vmax) in patients with aortic valve diseases, from the SCG signals. |
| 3651 | Computer 68
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Evaluation of PC-MRI Flow in Adults Using a Deep Learning-Based Reconstruction Trained on Pediatric Data |
| Matthew J. Middione1, Julio A. Oscanoa1,2, Xianglun Mao3, Christina R. Ruiz4, Michael Salerno1,4,5, Shreyas S. Vasanawala1, and Daniel B. Ennis1,5 | ||
1Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Bioengineering, Stanford University, Stanford, CA, United States, 3GE HealthCare, Menlo Park, CA, United States, 4Department of Medicine, Stanford University, Stanford, CA, United States, 5Cardiovascular Institute, Stanford University, Stanford, CA, United States |
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Keywords: Flow, Machine Learning/Artificial Intelligence, Phase Contrast We have previously trained a deep learning-based (DL) reconstruction for 2D PC-MRI using fully-sampled (n=194) raw k-space pediatric datasets. This DL-based reconstruction provided up to 9x undersampling with ≤5% error in accuracy and precision of peak velocity and total flow. Herein, we analyze this pediatric trained DL-based reconstruction in adult volunteers (n=3) and adult patients (n=8) and show that our DL-based reconstruction provides ~5% error in accuracy and precision of peak velocity and total flow for up to 7x undersampling. |
| 3652 | Computer 69
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Supervised automation of “whole-chest” 4D flow MRI analysis from original DICOM files to quantification of aortic pulse wave velocity |
| Kelly Jarvis1, Ethan Johnson1, Haben Berhane1, Adam Richter1, Elizabeth Weiss1, and Michael Markl1 | ||
1Department of Radiology, Northwestern University, Chicago, IL, United States |
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Keywords: Flow, Data Processing Analysis of pulse wave velocity by 4D flow MRI usually involves a manual processing pipeline with multiple steps of active use. We set out to automate the entire pipeline from original DICOMs to parameter quantification for evaluation of “whole-chest” 4D flow MRI. A deep learning algorithm trained on aortic acquisitions was used to facilitate segmentation. The supervised automation pipeline allowed for shorter analysis times and less user interaction, enabling the user to focus on refining aortic segmentations generated by deep learning. Results were comparable, but additional work including adjustment of preprocessing settings and retraining of CNN is warranted for optimization. |
| 3653 | Computer 70
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Improving the segmentation over time of 4D flow MRI images, using a medical image registration neural network VoxelMorph |
| Aaron Christhoper Ponce1,2, Sergio Uribe2,3,4,5, and Julio Sotelo2,5,6 | ||
1School of Informatics Engineering, Universidad de Valparaíso, Valparaíso, Chile, 2Millennium Institute for Intelligent Healthcare Engineering, iHEALTH, Santiago, Chile, 3Department of Radiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, 4Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile, 5Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile, 6School of Biomedical Engineering, Universidad de Valparaíso, Valparaíso, Chile |
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Keywords: Flow, Segmentation The segmentation of large vessels in 4D Flow MRI remains a challenge, due to different problems such as random acquisition noise, low spatial and temporal resolution, velocity aliasing, respiratory motion, phase offsets. For that reason the use of a single segmentation has been standardized to represent the geometry throughout all the cardiac phases. However, recent studies have proposed the use of image registration to be able to solve this problem. In this work, an algorithm based on a medical image registration neural network is proposed to improve the segmentation over time for the cardiac phases of the systole period. |
| 3654 | Computer 71
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Reconstructing 3D Velocity and Pressure Fields From 2D Flow Measurements Using Physics Informed Neural Networks |
| Stefano Buoso1, Pietro Dirix1, and Sebastian Kozerke1 | ||
1Institute of Biomedical Engineering, ETH Zurich, Zurich, Switzerland |
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Keywords: Flow, Velocity & Flow We propose physics-informed neural networks to augment 2D phase-contrast flow measurements in order to reconstruct full 3D velocity and pressure fields. In this conceptual work, 2D flow measurements are assimilated using the incompressible Navier-Stokes equations defined on the vessel anatomy reconstructed from anatomical scans. The network leverages a low-rank representation of velocity and pressure fields as physical prior and it is demonstrated to reconstruct 3D velocity and pressure gradient fields with good accuracy. |
| 3655 | Computer 72
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View-Sharing and KWIC Filtering Deblur 64-fold Accelerated Real-Time Phase-Contrast MRI Obtained with Radial k-space Sampling |
| Huili Yang1,2, Andrine Larsen3, Joshua D Robinson4, KyungPyo Hong1, Cynthia K Rigsby5, and Daniel Kim1,2 | ||
1Radiology, Northwestern University, Chicago, IL, United States, 2Biomedical Engineering, Northwestern University, Evanston, IL, United States, 3Biomedical Engineering, Lehigh University, Bethlehem, PA, United States, 4Pediatrics, Ann & Robert H. Lurie Children’s Hospital, Chicago, IL, United States, 5Medical Imaging, Ann & Robert H. Lurie Children’s Hospital, Chicago, IL, United States |
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Keywords: Flow, Cardiovascular, compressed sensing, real-time imaging, phase-contrast MRI Highly-accelerated real-time phase-contrast (rt-PC) using compressed sensing may underestimate (~17%) velocity measurements due to over regularization. We sought to address this underestimation by incorporating view-sharing (VS) and k-space weighted image contrast (KWIC) filtering. This is particularly important for pediatric patients who have faster heart rates and smaller hearts than adults, it is particularly important to achieve high temporal resolution. The proposed reconstruction achieves 25 ms temporal resolution without significant temporal blurring artifacts. |
| 3656 | Computer 73
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Digital Twinning of Aortae from 2D+time MRI |
| Gloria Wolkerstorfer1, Stefano Buoso1, and Sebastian Kozerke1 | ||
1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland |
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Keywords: Flow, Data Analysis, Aorta; Shape modelling; Shape reconstruction; Image-based shape reconstruction; Aortic shape reconstruction We propose an automatic pipeline to generate digital twin aortae from 2D+time MRI slices. First, a statistical shape model is fitted to the segmentation of 2D slices over time and then local refinements are applied to closely match dynamics over time. The approach is exemplified on a dataset of 10 aortic stenosis patients on which we quantify the impact of the number of available slices on the reconstructed anatomy. |
| 3657 | Computer 74
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Deformation-ENcoding Transformer (DENT) for High Frame Rate for Phase Contrast MRI |
| Manuel A Morales1, Amine Amyar1, Siyeop Yoon1, Jennifer Rodriguez1, Martin S Maron2, Ethan J Rowin2, Shiro Nakamori1, Jiwon Kim3, Robert M Judd4, Jonathan W Weinsaft3, Warren J Manning1, and Reza Nezafat1 | ||
1BIDMC, Boston, MA, United States, 2Tufts Medical Center, Boston, MA, United States, 3Weill Cornell Medicine, New York, NY, United States, 4Duke University, Durham, NC, United States |
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Keywords: Flow, Cardiovascular Quantification of blood flow using 2D or 4D phase-contrast (PC) MRI is routinely being used to evaluate blood flow in cardiovascular disease. However, PC has only a modest temporal resolution compared to echocardiography. We sought to develop a deformation-encoding transformer (DENT) model for cardiac frame interpolation and evaluate its potential in increasing temporal resolution. DENT was trained using a large multi-center (centers = 3), multi-vendor (vendors = 3) and multi-field strength (1.5T, 3T) cine MRI dataset (patients = 3178). The model was successfully applied to 2D/4D-PC MRI without modifications, enabling a 2-fold gain in temporal resolution. |
| 3658 | Computer 75
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Radial phase-contrast FLASH acquisiton with SSA-FARY utilizing a Hadarmad-encoding sheme |
| Vanessa Thiesen1, Ansgar Adler1, and Martin Uecker1,2,3 | ||
1Institute of Biomedical Imaging, Graz, Austria, 2Institute for Diagnostic and Interventional Radiology of the University Center Göttingen, Göttingen, Germany, 3DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany |
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Keywords: Flow, Velocity & Flow The assessment of flow within a heart cycle places high demands on the temporal resolution of the measurement protocol. With self-gating we can exploit the quasi-periodicity of cardiac and respiratory motion to meet this challenge. We combined a Hadamard flow-encoding scheme together with SSA-FARY to further elaborate on the idea of a flow measurement with a high temporal and spatial resolution. The approach delivered promising results in 2D and can be seen as a basis for further developement towards 3D flow MRI. |
| 3659 | Computer 76
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Accelerated phase-contrast for diastolic function evaluation using k-t PCA methods |
| Jie Xiang1, Jerome Lamy2, Gigi Galiana1,2, and Dana C. Peters1,2 | ||
1Department of Biomedical Engineering, Yale University, New Haven, CT, United States, 2Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States |
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Keywords: Flow, Quantitative Imaging Diastolic function evaluation requires estimates of early and late diastolic mitral valve flow velocities (E and A), normally evaluated by echocardiography, using phase contrast (PC). Our goal was to investigate k-t principal component analysis (PCA), constrained by either global and local principal components, for E and A measurements. Importantly, we found that retaining the central k-space used in estimating the principal components improved the final velocity maps. We compared local PCA with global PCA. Retrospectively undersampled images showed strong agreement with standard PC acquisitions. Higher E and A were observed using higher temporal resolution in prospective k-t PCA PC acquisitions. |
| 3660 | Computer 77
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Investigation of 4D Flow CMR technique for left ventricular hemodynamics in heart failure patients |
| Guo Jiaxuan1, Yue Xiuzheng2, Huang shan2, and Zhu Li3 | ||
1Ningxia medical university, Yinchuan, China, 2Philips Healthcare, Beijing, China, 3General Hospital of Ningxia Medical University, Yinchuan, China |
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Keywords: Heart, Cardiovascular, Heart Failure The number of patients with heart failure is increasing. Our study is based on the 4D flow technique of cardiac magnetic resonance and attempts to find cardiac functional parameters that precede structural changes in the heart at the level of the ventricular inflow and outflow tracts. We have found easier methods for visualizing blood flow and have the potential to further advance clinical diagnosis. |
| 3661 | Computer 78
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Validation of real-time phase contrast MRI with online compressed sensing reconstruction in phantom and patients |
| Tania Lala1, Lea Christierson2,3, Petter Frieberg1, Daniel Giese4,5, Nina Hakacova 2, Pia Sjöberg1, Ellen Ostenfeld1, and Johannes Töger1 | ||
1Clinical Physiology, Department of Clinical Sciences Lund, Skåne University Hospital, Lund University, Lund, Sweden, 2Department of Clinical Sciences Lund, Pediatric Heart Center, Skåne University Hospital, Lund University, Lund, Sweden, 3Department of Biomedical Engineering, Lund University, Lund, Sweden, 4Magnetic Resonance, Siemens Healthcare GmbH, Erlangen, Germany, 5Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany |
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Keywords: Flow, Velocity & Flow Real-time Phase Contrast MRI with Compressed Sensing reconstruction is a promising method to image cardiac flow in patients with arrhythmia, where cardiac-gated sequences fail. In this study, we compared it against the gated standard clinical flow MRI using a phantom model and in patients. The phantom underwent pulsatile periodic and non-periodic flow. For in vivo validation, non-arrhythmic patient data (N=10) and data from patient with atrial fibrillation (N=1) were collected from the ascending aorta. Non-periodic flow was captured both in the phantom and in vivo. Real-time MRI showed good accuracy in net flow quantification and underestimated peak flow. |
| 3662 | Computer 79
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Utility of Noncontrast-enhanced Turbo-field Echo-planar Imaging-based 4D Flow MRI for Portal Venous System |
| Naoya Kinota1,2, Daisuke Abo3, Daisuke Kato1, Satonori Tsuneta3, Noriko Nishioka1, Kinya Ishizaka4, Noriyuki Fujima3, Kazuyuki Minowa5, and Kohsuke Kudo1,6 | ||
1Department of Diagnostic Imaging, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, 2Department of Dental Radiology, Hokkaido University Hospital, Sapporo, Japan, Japan, 3Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan, 4Department of Radiological Technology, Hokkaido University Hospital, Sapporo, Japan, 5Department of Radiology, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan, 6Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sapporo, Japan |
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Keywords: Vessels, Velocity & Flow Echo-planer imaging-based three-dimensional cine phase contrast (4D flow) MRI has been reported to achieve good image quality with a short acquisition time in cardiovascular imaging, but its application to the portal venous (PV) system has not been reported. In this study, the turbo-field echo-planar imaging (TFEPI) 4D flow MRI with a turbo-field echo (TFE)-based one in the PV system was compared. The TFEPI sequence showed a better image quality and flow consistency at the splenic and superior mesenteric vein confluence with a shorter acquisition time compared to the conventional TFE-based one. |
| 3819 | Computer 61
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Evaluation of pulmonary artery hemodynamic changes in COPD patients with different emphysema volume by using 4D-Flow MRI |
| Jiwei Sun1, Hong Zhang1, Anhong Yu1, Jianxiu Lian2, Yufan Gao1, Wei Yuan1, and Yapeng Yang1 | ||
1Radiology, Tianjin Chest Hospital, Tianjin, China, 2Philips Healthcare, Beijing, China |
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Keywords: Flow, Blood, hemodynamic Few studies quantitatively evaluate pulmonary artery hemodynamic changes caused by emphysema. 34 COPD patients were divided into two groups according to emphysema volume and 12 healthy volunteers were matched. Hemodynamic parameters were calculated by 4D-Flow MRI and right ventricular function indicators were evaluated for three groups. The right systolic pressure drop and RVEF were lower in moderate and severe emphysema group but the right EL was higher. The whole-lung emphysema score correlated negatively with RVEF and the right systolic pressure drop. 4D-Flow combined with cine image can comprehensively evaluate the pulmonary artery hemodynamics and right ventricular function of COPD patients. |
| 3820 | Computer 62
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3D phase contrast blood flow measurements in the coronary arteries |
| Denise Lichthardt1, Jens Wetzl2, Michaela Schmidt2, Peter Speier2, Armin M. Nagel1, and Daniel Giese2 | ||
1Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany, 2Siemens Healthcare GmbH, Erlangen, Germany |
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Keywords: Flow, Cardiovascular Phase contrast MRI enables flow measurement in the coronary arteries. Herewith we propose a 3D Flow sequence and present a novel 3D visualization and quantification tool. Whole heart 3D PC measurements were performed in more than 20 healthy volunteers. An isotropic resolution of 1.2x1.2x1.2mm3 was used, as well as an undersampling factor of 14 in combination with a compressed sensing reconstruction. Our postprocessing tool was used for the 3D visualization of blood flow information as well as quantification of flow velocities per slice perpendicular to the vessel centerline.
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| 3821 | Computer 63
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Quantitative characterization of hemodynamic parameters in pediatric patients with connective tissue disorders |
| Aparna Sodhi1, Ethan Johnson2, Elizabeth Weiss2, Haben Berhane2, Dr. Joshua Robinson3, Dr. Andrada Popescu1, Dr. Michael Markl2, and Dr. Cynthia Rigsby1 | ||
1Department of Medical Imaging, Ann & Robert H Lurie Children's Hospital, Chicago, IL, United States, 2Department of Radiology, Northwestern University, Chicago, IL, United States, 3Department of Cardiology, Ann & Robert H Lurie Children's Hospital, Chicago, IL, United States |
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Keywords: Flow, Cardiovascular, Marfan Syndrome, Loeys-Dietz Syndrome, Vascular Ehlers-Danlos syndrome Quantitative overview of 4D flow derived aortic hemodynamic parameters such as kinetic energy, peak velocity, and pulse wave velocity in a cohort of pediatric patients with connective tissue disorders such as Marfan Syndrome (MFS), Loeys-Dietz Syndrome (LDS), and Vascular Ehlers-Danlos Syndrome (EDS), using a fully automated pipeline. A statistically significant trend of increased pulse wave velocity - an important measure of vessel stiffness, with increasing age was observed for this cohort. No association was found between PWV and all mean aortic diameters when controlled for age. |
| 3822 | Computer 64
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Flow Displacement and Wall Shear Stress in Individuals with Mild-to-Moderate Aortic Dilation and Tricuspid Aortic Valves |
| Chiara Trenti1,2, Filip Hammaréus1, Tino Ebbers1,2, Eva Swahn1,3, Lena Jonasson1, and Petter Dyverfeldt1,2 | ||
1Department of Health, Medicine and Caring Sciences (HMV), Linköping University, Linköping, Sweden, 2Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 3Department of Cardiology in Linköping, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden |
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Keywords: Flow, Vessels, Aorta Altered hemodynamics may play a role in the development of ascending aortic aneurysms. In this study, we sought to investigate wall shear stress and flow displacement in patients with tricuspid aortic valve and mild-to-moderate dilatation of the ascending aorta, and age-and sex- matched non-dilated controls. Dilated patients had lower average velocity and wall shear stress in the ascending aorta, and higher flow displacement. This study shows that individuals with dilatation have altered hemodynamics even in an early stage of the disease. |
| 3823 | Computer 65
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Reproducibility of wall shear stress in abdominal aortic aneurysms estimated by 4D flow magnetic resonance imaging |
| Eva Aalbregt1,2, Aart J. Nederveen2, Kak Khee Yeung1, R. Nils Planken2, Ron Balm 1, and Pim van Ooij2 | ||
1Vascular Surgery, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands, 2Radiology & Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, Netherlands |
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Keywords: Flow, Quantitative Imaging, abdominal aortic aneurysm The aim of this study was to assess the reproducibility and inter- and intra-observer agreement for estimating wall shear stress (WSS) in abdominal aortic aneurysms (AAAs) based on 4D flow magnetic resonance imaging (MRI). Asymptomatic AAA patients were included and scanned twice with a one-week interval. Phase-contrast angiographies were acquired by voxel-wise multiplication of magnitude and phase data. Based on statistical analyses the reproducibility was good. An inverse correlation was found between WSS and lumen diameter. Both vorticity and intraluminal thrombus volume were associated with minimum WSS in AAA. 4D flow MRI is robust for estimating WSS in AAAs. |
| 3824 | Computer 66
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Patients with liver cirrhosis have more stagnant portal venous blood flow compared to non-cirrhotic subjects: analysis using 4D flow MRI |
| Ryota Hyodo1, Yasuo Takehara1,2, Takashi Mizuno3, Kazushige Ichikawa4, Yoji Ishizu5, Yasuhiro Ogura6, and Shinji Naganawa7 | ||
1Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Fundamental Development for Advanced Low Invasive Diagnostic Imaging, Nagoya University Graduate School of Medicine, Nagoya, Japan, 3Radiological Technology, Nagoya Uviversity Hospital, Nagoya, Japan, 4RadiologicalTechnology, Nagoya Uviversity Hospital, Nagoya, Japan, 5Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 6Transplantation Surgery, Nagoya Uviversity Hospital, Nagoya, Japan, 7Nagoya University Graduate School of Medicine, Nagoya, Japan |
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Keywords: Flow, Velocity & Flow Although liver cirrhosis is an independent risk factor for portal vein thrombosis (PVT), the individual thrombotic risk assessment is complex. Recently, 4D flow MRI has begun to assess portal blood flow; however, there have been no reports of the use of RRT, an indicator of blood flow stagnation, in the portal system. RRT may be used to measure the risk of PVT in liver cirrhosis. In this study, we evaluated the mean RRT value of the main PV calculated with 4D flow MRI and found that the value was significantly higher in cirrhotic patients than in non-cirrhotic subjects. |
| 3825 | Computer 67
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The Value of 4D Flow MRI Combined with Precontrast T1 mapping Model in Identifying High-risk Varices of Cirrhosis Patients |
| Xiaohuan Li1, Zhou Wei1, Zhiyuan Chen1, Dongjing Zhou1, Shuping Zhang1, Ruhang Huang1, Yunzhu Wu2, and Yupin Liu*1 | ||
1Department of radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China, 2MR Scientific Marketing, Siemens Healthineers Ltd, Shanghai, China |
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Keywords: Flow, Velocity & Flow Noninvasive identification of high-risk varices (HRV) in cirrhosis patients is of significantly value because it could help avoid some unnecessary upper gastrointestinal endoscopy and repeat in a short time to evaluate the efficiency of non-selective beta blockers therapy. This study aims to evaluate the value of 4D flow MRI combined with precontrast T1 in identifying HRV. Our results indicated that the model including SMV forward volume, SMV maximum blood flow, precontrast liver T1 mapping, and precontrast spleen T1 mapping could effectively identify HRV of cirrhosis patients. |
| 3826 | Computer 68
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Evaluation of turbulent Kinetic energy and Viscous energy loss on 4D flow MRI in patients with hypertrophic cardiomyopathy |
| Tetusro Sekine1 and Shinichiro Kumita1 | ||
1Nippon Medical School, Tokyo, Japan |
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Keywords: Flow, Cardiovascular The purpose was to validate whether turbulent kinetic energy (TKE) and viscous energy loss (VEL) reflect the condition of hypertrophic cardiomyopathy (HCM). We included consecutive 32 HCM patients. They were classified into HOCM (HCM with left ventricular outflow tract obstruction [LVOTO]) (n=21) and HNCM (HCM without LVOTO) (n=11) based on cardiac ultrasound. Both TKE and VEL were significantly higher in HOCM than HNCM. The strong correlation was observed between normalized LVmass and normalized TKEpeak in asymptomatic HCM (nTKEpeak r=0.879, p<0.001), but not in symptomatic HCM. The TKEpeak had the strongest correlation to each disease condition than the others. |
| 3827 | Computer 69
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Oscillatory Wall Shear Stress in patients with Bicuspid Aortic Valve and Aortic Regurgitation |
| Chiara Trenti1,2, Petter Dyverfeldt1,2, Paul W.M. Fedak3, James A. White3, and Julio Garcia3,4,5,6 | ||
1Department of Health, Medicine and Caring Sciences (HMV), Linköping University, Linköping, Sweden, 2Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 3Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 4Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, Calgary, AB, Canada, 5Department of Radiology, University of Calgary, Calgary, AB, Canada, 6Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada |
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Keywords: Flow, Vessels, Aorta Individuals with bicuspid aortic valve (BAVs) and aortic regurgitation have higher rate of aortic complications compared to individuals with stenotic and functioning BAVs. We sought to investigate wall shear stress (WSS) and oscillatory shear index (OSI) in the ascending aorta of BAVs with functioning valves, stenotic and regurgitant valves, as well as controls with tricuspid aortic valves. BAVs with regurgitation had similar WSS compared to all other groups, but OSI was almost twice as high. This finding may be related to the pendulum volume between the aorta and the left ventricle. Studying OSI may improve the understanding behind BAV aortopathy. |
| 3828 | Computer 70
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Assessment of Altered Hemodynamics in Patients with Hypertrophic Obstructive Cardiomyopathy using 4D Flow MRI |
| Yun Zhao1, Lu Huang1, Xiaoyue Zhou2, and Liming Xia1 | ||
1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2MR Collaboration, Siemens Healthineers Ltd, Shanghai, China |
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Keywords: Flow, Blood, 4D flow MRI; Hemodynamics; Energy loss; Hypertrophic Obstructive Cardiomyopathy; Hypertrophic Obstructive Cardiomyopathy (HOCM) is characterized by dynamic obstruction of blood flow in the left ventricular outflow tract. 4D flow MRI can be used for comprehensive evaluation of cardiac and aortic hemodynamics by visualization of the complex spiral LVOT 3D blood flow patterns. This study used 4D flow MRI to evaluate the degree of LVOT obstruction and the flow energy loss in patients with HOCM. The results showed that spiral flow and viscous energy loss were associated with the LVOT pressure gradient, and played a role in structural remodeling of the left ventricle. |
| 3829 | Computer 71
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Association between angioarchitecture and flow parameters in ruptured and unruptured arteriovenous malformation: a pilot study by 4D flow MR |
| Yuting Wang1, Haining Wei2, Meixiong Cheng3, Yishuang Wang1, Yunzhu Wu4, Mingzhu Fu2, and Rui Li2 | ||
1Radiology, Sichuan Provincial People's Hospital, Chengdu, China, 2Center for Biomedical Imaging Research Beijing, Qinghua University, Beijing, China, 3Neurosurgery, Sichuan Provincial People's Hospital, Chengdu, China, 4Siemens Healthineers Ltd., Shanghai, China |
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Keywords: Flow, Velocity & Flow, arteriovenous malformation The hemodynamics of cerebral AVM likely vary with lesion angioarchitecture and the rupture status, which couldn’t be reflected by morphology-based imaging. In this pilot study, 9 patients with AVM had their complicated feeding/draining patterns visualized by 4D-flow MR. AVM tend to have heterogeneous hemodynamics even with the same Spetzler-Martin grade or similar angioarchitecture. It tends to have smaller flow of the feeding artery after rupture. AVM with deep vein drainage tends to have diffused nidus and higher wall shear stress adjacent to the nidus. Higher flow of the feeding artery was associated with higher dynamic pressure and larger nidus volume. |
| 3830 | Computer 72
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Hemodynamic analysis of intracranial aneurysms before and after flow diverter stents implantation based on 4D Flow MRI |
| Yuxin Liu1, Haining Wei1, Tian Bing2, Hou Yuxi2, Mingzhu Fu1, and Rui Li1 | ||
1Center for Biomedical Imaging Research, Tsinghua University, Beijing, China, 2Changhai Hospital, Shanghai, China |
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Keywords: Flow, Velocity & Flow, Hemodynamics Intracranial aneurysm has become an important issue because of the high morbidity and the high mortality rate due to aneurysm rupture. Recently, the flow diverter stent has been considered as an effective device for the treatment of aneurysms by modifying the hemodynamics of the aneurysm. 4D Flow MRI can can offer three-dimensional visualization of blood flow pattern and a comprehensive analysis of hemodynamics. In this study, we calculated and analyzed the hemodynamics in aneurysm hemodynamics before and after the implantation of flow diverter stents based on 4D Flow MRI. |
| 3831 | Computer 73
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Hemodynamics of common iliac arteries is associated with the risk of abdominal aortic aneurysm: assessment using 4D flow MRI |
| Wen Zeng1, Chunchao Xia1, Xiaoyong Zhang2, and Zhenlin Li1 | ||
1West China Hospital, Sichuan University, Chengdu, China, 2Clinical Science, Philips Healthcare, Chengdu, China, Chengdu, China |
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Keywords: Flow, Cardiovascular, Abdominal aortic aneurysm Studies have confirmed the interaction between iliac arteries and abdominal aortic aneurysms. Four-dimensional (4D) flow MRI can reveal the hemodynamic changes of common iliac arteries in abdominal aortic aneurysm and health controls. In this study, we tried to explain the relationship between the changes of iliac artery hemodynamics and the asymmetry of the left and right iliac artery blood flow and the occurrence and development of abdominal aortic aneurysms in patients. |
| 3832 | Computer 74
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Evaluation of diastolic ventricular interdependence using simultaneous left and right heart transvalvular real time phase contrast CMR |
| Simon Thalén1, Peder Sörensson2, Daniel Giese3, Andreas Sigfridsson1, and Martin Ugander1,4 | ||
1Department of Clinical Physiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden, 2Department of Cardiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden, 3Siemens Healthineers, Erlangen, Germany, 4Kolling Institute, Royal North Shore Hospital, and Charles Perkins Centre, Sydney, Australia |
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Keywords: Flow, Velocity & Flow, Ventricular interdependence Diastolic ventricular interdependence occurs in several clinical settings, most notably pericardial effusion and constrictive pericarditis. It is measured using Doppler echocardiography or invasive cardiac catheterization where the respiratory variation in velocity or pressure is measured. In pericardial effusion it is an early sign of hemodynamic significance which is not always correlated to the volume of effusion. In constrictive pericarditis, it is used to separate constrictive and restrictive physiologies. In this study a method to measure diastolic ventricular interdependence by simultaneously quantifying the respiratory variation in mitral and tricuspid early inflow velocities using real time phase contrast CMR is presented. |
| 3833 | Computer 75
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Interval Changes in 4D Flow-Derived Hemodynamic Parameters Stratify Type B Aortic Dissection Patients and Correlate with 2D Through-Plane Flow |
| Josh Engel1, Ozden Kilinc1, Justin Baraboo2, Elizabeth Weiss1,2, Christopher Mehta3, Andrew Hoel4, S. Chris Malaisrie3, Michael Markl2, and Bradley Allen1 | ||
1Radiology, Northwestern University, Chicago, IL, United States, 2Biomedical Engineering, Northwestern University, Chicago, IL, United States, 3Cardiac Surgery, Northwestern Medicine, Chicago, IL, United States, 4Vascular Surgery, Northwestern Medicine, Chicago, IL, United States |
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Keywords: Vessels, Velocity & Flow, Aortic Dissection, 4D Flow We investigated whether changes in 4D flow-derived hemodynamic parameters stratified type B aortic dissection patients and sought to validate a 4D flow-derived 2D planar false lumen flow method. Patient scans with baseline and follow-up 4D flow at least 120 days apart were manually segmented into true and false lumens. Voxel-wise parametric maps and 2D forward and reverse flow in the descending aorta were calculated. Changes in voxel-wise hemodynamic parameters significantly correlated with aortic growth rate, with changes in false lumen reverse flow as the most robust parameter. 2D planar flow correlated with voxel-wise flow, but not aortic growth. |
| 3834 | Computer 76
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Ventricular flow analysis and its Association with cadiac function and structure of hypertrophic cardiomyopathy: 4D flow CMR study |
| Yuying Chen1, Yang Peng1, Yu Feng1, Jun Yuan1, Lin Peng1, Mengzhu Wang2, and Ning Jin3 | ||
1The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 2MR Scientific Marketing, Siemens Healthineers Ltd., Guangzhou, China, 3Siemens Medical Solutions USA, Inc. Customer Solutions Group，Siemens Healthineers, MR Scientific Marketing, Siemens Healthineers Ltd., Chicago, IL, United States |
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Keywords: Cardiomyopathy, Cardiomyopathy, 4D flow This study aimed to investigate the potential of ventricular flow parameters derived from four‑dimensional (4D) flow cardiovascular magnetic resonance (CMR) to accurately support assessment of hypertrophic cardiomyopathy (HCM). Our results show that reduced left ventricular (LV) residual volume was associated with LV dysfunction. Higher LV retained inflow and lower delayed ejection inflow were observed in obstructive HCM patients. Flow components and kinetic energy correlated significantly with LV functional and remodelling CMR parameters. These findings suggest that 4D flow CMR may be potential method to explain the relationship between hemodynamic and pathophysiological changes in HCM. |
| 3835 | Computer 77
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Quantitative Mitral Valvular Regurgitation Hemodynamics Analysis Using 4D flow MRI and Echocardiography: Characteristics of Flow Momentum |
| Jeesoo Lee1, Adarsh Aratikatla1, Erik Wu2, Taimur Safder3, Gloria Ayuba3, James Thomas3, and Michael Markl4 | ||
1Radiology, Northwestern University, Chicago, IL, United States, 2Northwestern University, Chicago, IL, United States, 3Cardiology, Northwestern Memorial Hospital, Chicago, IL, United States, 4Radiology, Northwestern University, chicago, IL, United States |
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Keywords: Valves, Velocity & Flow, Mitral valvular regurgitation, 4D flow MRI, Jet momentum Quantitative hemodynamic assessment of mitral valvular regurgitation (MVR) is critical for evaluating severity of the disease, but has been challenging with conventional echocardiographic and cardiac MRI techniques. 4D flow MRI is a promising tool that enables direct retrospective quantification of MVR hemodynamics. This study proposes a regurgitant flow momentum as a novel and reliable fluid dynamic parameter for MVR assessment using 4D flow MRI. The conservation characteristics of MVR jet flow momentum and its relationship with LA enlargement were investigated in 44 patients using 4D flow MRI and echocardiography. |
| 3836 | Computer 78
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Effect of age on the evaluation of left ventricular kinetic energy from 4d-flow CMR |
| Jingyu Zhang1, Di Tian1, Ziqi Xiong1, Yifan He1, and Zhiyong Li1 | ||
1The First Affiliated Hospital of Dalian Medical University, Dalian, China |
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Keywords: Heart, Heart Four-dimensional flow cardiovascular magnetic resonance imaging (4d-flow CMR) left ventricular kinetic energy (LVKE) parameter Peak A- wave KEiEDV increased, KEiEDV E/A ratio decreased with age. This suggests that 4d-flow CMR LVKE parameters can respond to age-induced changes in LV diastolic function. |
| 3837 | Computer 79
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Exploration of age-related hemodynamic and mechanical changes in the human thoracic aorta using an atlas based approach |
| Elodie Piot1, Nicolas Duchateau1, Marine Menut2, Benyebka Bou-Said2, Patrick Clarysse1, Philippe Douek1,3, Karl Kunze4, Rene Botnar5, Sara Boccalini6, Claudia Prieto5, and Monica Sigovan1 | ||
1CREATIS, Lyon, France, 2INSA de Lyon, Lyon, France, 3Departement of Radiology, HCL, Lyon, France, 4Siemens Helthineers, London, United Kingdom, 5School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 6Department of Radiology, HCL, Lyon, France |
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Keywords: Data Processing, Blood vessels Understanding the hemodynamic involvement in a vascular pathology requires inter-subject comparisons that are not straightforward due to variability in terms of aorta morphology. Hemodynamic atlases can facilitate detection of intra-group characteristics. We propose here a workflow to create a hemodynamic atlas using 4D Flow MRI. In addition, we propose to investigate the aorta wall stiffness using non-rigid image registration and inverse mechanical modeling. This type of analysis is expected to improve pathophysiological understanding of vascular disease, by enabling the investigation of potential correlations between hemodynamic and wall mechanical properties at each point of the aorta. |
| 3994 | Computer 61
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Multiparametric Cardiac Magnetic Resonance Reveals Persistent Myocardial injury in Patients with Exertional Heat illness |
| Song Luo1, Jun Zhang1, and Wei Qiang Dou2 | ||
1Jinling Hospital, Medical School of Nanjing University, Nanjing, China, 2GE Healthcare, Bei Jing, China |
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Keywords: Inflammation, Cardiovascular To explore the clinical potential of multiparametric cardiac magnetic resonance (CMR) in evaluating myocardial injury in patients with exertional heat illness (EHI).This prospective study enrolled 28 male with EHI and 18 age-matched male healthy controls. All subjects underwent CMR, and 9 patients had follow-up CMR measurements 3 months after recovery from EHI. As shown in this study, EHI patients have left ventricular dysfunction, myocardial edema and fibrosis, and persistent myocardial injury at 3-month follow-up after the EHI episode. This knowledge has an important role in guiding patients recovering from EHI back to a return to work, play or duty, respectively. |
| 3995 | Computer 62
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T2*BOLD for evaluating coronary arteries with hemodynamic changes in stable multivessel coronary artery disease |
| Lei Zhao1, Weibo Chen2, Yongyi Wang1, Song Xue1, and Lianming Wu1 | ||
1Renji Hospital, Shanghai, China, 2Philips Healthcare, Shanghai, China |
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Keywords: Vessels, Cardiovascular, T2*-mapping This study used T2*BOLD and QFR to evaluate coronary arteries with hemodynamic changes in coronary artery disease. Fifty patients with at least 1 significant coronary artery stenosis (diameter stenosis >50%) and 21 healthy control subjects underwent coronary angiography combined with QFR measurements and CMR. The CMR protocol consisted of T2* mapping and resting perfusion, contrasted with QFR. QFR≤0.80 was considered to indicate the presence of hemodynamic obstruction. Our study revealed that T2* BOLD and QFR have good agreement in detecting hemodynamic changes of stenotic coronary arteries. T2* BOLD is superior to semiquantitative perfusion imaging in analyzing myocardial perfusion without stress. |
| 3996 | Computer 63
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Rapid Myocardial T1 Stress/Rest Reactivity Mapping in Ferumoxytol-enhanced Cardiac MRI: Initial Results |
| Hazar Benan Unal1, Shahriar Zeynali1, Fei Han2, Gregory J. Anthony3, Subha Raman4, Balaji Tamarappoo5, Rohan Dharmakumar1, and Behzad Sharif1 | ||
1Krannert Cardiovascular Research Center, Indiana University School of Medicine, Indianapolis, IN, United States, 2Siemens Medical Solutions, Inc., Los Angeles, CA, United States, 3Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, United States, 4Cardiovascular Medicine, IU Health/IU School of Medicine, Indianapolis, IN, United States, 5Indiana University Health, Indianapolis, IN, United States |
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Keywords: Myocardium, Ischemia, dobutamine Myocardial T1 reactivity, defined as the relative T1 change from rest to stress, has been proposed as a marker for detection of ischemic heart disease. SASHA-based T1 mapping provides higher accuracy than MOLLI, but the scan time can be prohibitive under stress. In this work, we investigated the feasibility of accelerated SASHA T1 mapping for ferumoxytol-enhanced dobutamine-stress T1 reactivity studies at 3T in a preclinical setting. We showed that a 2-fold accelerated SASHA T1 mapping can provide sufficiently accurate results compared to conventional SASHA. |
| 3997 | Computer 64
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Multiparametric 3D cardiac MR for simultaneous bright- and black-blood imaging and joint T1/T2 myocardial tissue mapping |
| Ivan Kokhanovskyi1,2,3, Michael G Crabb2, Karl P Kunze2,4, Radhouene Neji2,4, Carl Ganter1, Donovan P Tripp2, Carlos Castillo-Passi2,5, Dimitrios C Karampinos1, Claudia Prieto2,5,6,7, and Rene M Botnar2,3,5,6,7 | ||
1Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany, 2School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 3Institute for Advanced Study, Technische Universität München, Garching, Germany, 4MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom, 5Millennium Institute for Intelligent Healthcare Engineering, Santiago, Chile, 6Escuela de Ingeniería, Pontificia Universidad Católica de Chile, Santiago, Chile, 7Instituto de Ingeniería Biológica y Médica, Pontificia Universidad Católica de Chile, Santiago, Chile |
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Keywords: Heart, Data Acquisition Accurate diagnosis of cardiac disease requires imaging with high spatial resolution and whole-heart coverage. Current clinical protocols acquire contrasts sequentially, in different 2D orientations during several breath-holds leading to long examination times and misregistration artifacts. To address these limitations, we present a novel free-breathing four-heartbeat sequence for simultaneous 3D whole-heart Assessment of Cardiovascular anaTomy via bright- and black-blood Imaging and T1/T2 myocardial tissue quantificatiON (ACTION). Sequence parameters are optimized with Bloch simulations to enhance the mapping sensitivity and to improve the quality of anatomical images. Primarily results in a standardized phantom and in-vivo show potential for comprehensive heart disease detection. |
| 3998 | Computer 65
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Cardiac magnetic resonance in survivors of critical illness: myocardial fibrosis and dysfunction are associated with acute kidney injury |
| Alexander Isaak1, Isabel Pomareda1, Narine Mesropyan1, Dmitrij Kravchenko1, Leon Bischoff1, Daniel Kuetting1, Ulrike Attenberger1, Sebastian Zimmer2, Jens-Christian Schewe3, Stefan Kreyer3, and Julian Luetkens1 | ||
1Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany, 2Clinic for Internal Medicine II, Heart Center, University Hospital Bonn, Bonn, Germany, 3Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany |
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Keywords: Cardiomyopathy, Quantitative Imaging, T1 and T2 Mapping In this prospective study, cardiac magnetic resonance (CMR) was performed in 48 intensive care unit (ICU) survivors of acute critical illness without prior known cardiac disease. CMR revealed previously unrecognized functional abnormalities, including reduced left ventricular ejection fraction and impaired strain values, as well as evidence of focal and diffuse myocardial fibrosis represented by positive late gadolinium enhancement lesions and elevated myocardial T1 mapping and ECV. Findings were more pronounced in ICU survivors who had experienced acute kidney injury. Unrecognized fibrotic and functional myocardial alterations may be a correlate of physical impairment in post-intensive care syndrome. |
| 3999 | Computer 66
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Navigator acceptance window width does not affect accuracy and precision in free-breathing 2D cardiac MR fingerprinting of the myocardium at 3T. |
| Pauline Calarnou1, Augustin C. Ogier1, Roger Hullin2, Philippe Meyer3, Jérôme Yerly1,4, and Ruud B. Van Heeswijk1 | ||
1Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 2Cardiology Service, Cardiovascular Department, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, Lausanne, Switzerland, 3Cardiology Service, Department of Medicine, Geneva University Hospital and University of Geneva, Switzerland, Geneva, Switzerland, 4CIBM, Lausanne, Switzerland |
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Keywords: Myocardium, Relaxometry We implemented and characterized a free-breathing 2D cardiac joint T1-T2 MR fingerprinting technique at 3T named PARMA that includes a lung-liver navigator to minimize through-plane motion. We assessed the effect of rejected navigators on the relaxation times. Joint T1-T2 maps with four different navigator acceptance window widths (NAWWs from ±4mm to ±32mm) were acquired in 6 healthy volunteers and compared to clinical routine techniques. The accuracy and precision of the maps resulting from the different NAWWs did not significantly differ, suggesting that the NAWW can be chosen as a balance between navigator inefficiency and through-plane motion. |
| 4000 | Computer 67
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Using Quantitative MR and Histology to Characterize Acute and Chronic DVT at 9.4T |
| Caroline D. Jordan1,2, Kavya Sinha2, Deborah C. Vela3, L. Maximillian Buja3,4, Christof Karmonik2,5, and Trisha L. Roy2,5 | ||
1School of Engineering Medicine, Texas A&M University, Houston, TX, United States, 2Houston Methodist Research Institute, Houston Methodist Hopsital, Houston, TX, United States, 3Department of Cardiovascular Pathology, Texas Heart Institute, Houston, TX, United States, 4Department of Pathology and Laboratory Medicine, University of Texas, Houston, Houston, TX, United States, 5Weill Cornell Medical College, Houston, TX, United States |
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Keywords: Vessels, Tissue Characterization, DVT, clot Deep venous thrombosis (DVT) is common. Mechanical thrombectomy may offer advantages compared to medical therapy alone, but it can be challenging to determine the optimal treatment. Six patients underwent thrombectomy, and the ex vivo clot was scanned at 9.4T. We acquired T1, T2, and T2* maps, and histologic content of red blood cells, fibrin, and collagen. R2 between RBC content and each relaxation time was R2 = 0.58 for T1, R2 = 0.82 for T2, and R2 = 0.69 for T2*. T1, T2, and T2* mapping of ex vivo DVT clots at 9.4T may be feasible for determining clot components. |
| 4001 | Computer 68
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Whole-heart simultaneous CINE T2mapping and coronary MR angiography |
| Kazuo Kodaira1, Masami Yoneyama2, Michinobu Nagao3, Mana Kato1, Takumi Ogawa1, Yutaka Hamatani1, Isao Shiina1, Yasuhiro Goto1, and Shuji Sakai3 | ||
1Department of Radiological Services, Tokyo Women's Medical University, Tokyo, Japan, 2Philips Japan, Tokyo, Japan, 3Department of Diagnostic imaging & Nuclear Medicine, Tokyo Women's Medical University, Tokyo, Japan |
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Keywords: Myocardium, Quantitative Susceptibility mapping T2mapping is generally obtained only in diastole. However, because myocardial edema can affect both diastole and systole, acquisition of T2mapping of different cardiac phases is desirable. In addition, CMRA is also necessary in post-MI. However, scanning all these sequences prolongs exam time and increases patient stress. To overcome this limitation, we report a new T2mapping technique that enables quantitative systolic and diastolic T2mapping and CMRA acquisition in one scan by using dynamic trigger delay. In this study, we demonstrate the feasibility of this approach in healthy volunteer examination. |
| 4002 | Computer 69
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Accelerated 3D free-breathing cardiac T2 mapping with tiny golden-angle hybrid trajectory and tyGRASP |
| Jiaojiao Hu1, Jiantai Zhou1, Wei Cui1, Yang Ji2, Benedictor Alexander Nguchu1, Yanming Wang1, Yong Zhang3, and Bensheng Qiu1 | ||
1Center for Biomedical Imaging, University of Science and Technology of China, Hefei, China, 2Wellcome Centre for Integrative Neuroimaging, FMRIB Division, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 3GE Healthcare, Shanghai, China |
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Keywords: Myocardium, Heart Cardiac diseases are characterized by complex 3D pathological structures, 3D cardiac T2 mapping can be used as a promising tool to describe different pathologies. However, 3D T2 mapping requires a long acquisition time, which makes scanning more sensitive to motion, especially for high spatial resolution imaging. In our study, we aim to develop an accelerated and robust 3D cardiac T2 mapping technique by combining bSSFP-based hybrid radial-cartesian sampling with tiny Golden angle RAdial Sparse Parallel (tyGRASP) MRI at 3 T. The results showed that our method can generate precise T2 values with an average scan time of 6.1±1.0 min. |
| 4003 | Computer 70
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Optimization of spin-lock preparation pulses for B1 and B0 insensitive cardiac T1ρ mapping |
| Haikun Qi1,2, Zhenfeng Lv1,2, Jian Xu3, and Peng Hu1,2 | ||
1School of Biomedical Engineering, ShanghaiTech University, Shanghai, China, 2Shanghai Clinical Research and Trial Center, Shanghai, China, 3UIH America, Inc., Houston, TX, United States |
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Keywords: Myocardium, Tissue Characterization Cardiac T1ρ mapping is a promising technique for assessment of myocardial fibrosis without exogenous contrast agent. However, its wide application is hindered by the sensitivity of T1ρ preparation to B1 and B0 inhomogeneities. In this study, the state-of-the-art constant spin-lock methods including the composite and adiabatic excitation continuous-wave spin-lock methods were investigated using numerical simulations to assess their robustness to field inhomogeneities, and validated in phantoms and a preliminary subject. Two T1ρ preparation modules were found to generate superior T1ρ mapping quality in the presences of B0 and B1 inhomogeneities, indicating the potential of clinical application of cardiac T1ρ MRI. |
| 4004 | Computer 71
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Ungated and free-breathing radial simultaneous multi-slice cardiac T1 mapping |
| Johnathan Le1,2, Jason Mendes2, Konstantinos Sideris3, Josef Stehlik3, Brent Wilson3, Edward DiBella1,2, and Ganesh Adluru1,2 | ||
1Biomedical Engineering, University of Utah, Salt Lake City, UT, United States, 2Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, United States, 3Cardiology, University of Utah, Salt Lake City, UT, United States |
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Keywords: Myocardium, Relaxometry Cardiac T1 mapping has been shown to be a promising method for assessing different cardiomyopathies. Most cardiac T1 mapping methods require ECG gating with long breath holds to capture specific desired cardiac phases and to minimize breathing motion. However, certain cardiomyopathies can make it difficult for patients to maintain a breath hold for the duration of a cardiac T1 mapping sequence. Furthermore, some of these diseases, for example atrial fibrillation with changing R-R intervals can make capturing a specific cardiac phase difficult. Here we propose a radial simultaneous multi-slice (SMS) cardiac T1 mapping sequence without ECG gating or breath holding. |
| 4005 | Computer 72
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Rapid multiple-breath-holds myocardial CINE T2-mapping with dynamic multiple trigger delay acquisition |
| Mana Kato1, Masami Yoneyama2, Michinobu Nagao3, Kazuo Kodaira1, Takumi Ogawa1, Yutaka Hamatani1, Isao Shiina1, Yasuhiro Goto1, and Shuji Sakai3 | ||
1Department of Radiological Services, Tokyo Women's Medical University, Tokyo, Japan, 2Philips Japan, Tokyo, Japan, 3Department of Diagnostic imaging & Nuclear Medicine, Tokyo Women's Medical University, Tokyo, Japan |
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Keywords: Heart, Heart T2-mapping is generally obtained only in diastole. However, because myocardial edema can affect both diastole and systole, acquisition of T2-mapping of different cardiac phases is desirable, but it prolongs examination time and increases patient stress. To overcome this limitation, we report a new T2-mapping technique using dynamic trigger delay which enables quantitative mapping at multiple cardiac phases in one scan. In this study, we demonstrate the feasibility of this approach in healthy volunteer examination. |
| 4006 | Computer 73
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Fast 3D free-breathing simultaneous T1 and T1ρ mapping for noncontrast myocardial tissue characterization at 3T |
| Haikun Qi1,2, Junpu Hu3, Jian Xu4, Jiayu Zhu3, René Rene Botnar5, Claudia Prieto5, and Peng Hu1,2 | ||
1ShanghaiTech University, Shanghai, China, 2Shanghai Clinical Research and Trial Center, Shanghai, China, 3United Imaging Healthcare, Shanghai, China, 4UIH America, Inc., Houston, TX, United States, 5School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom |
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Keywords: Myocardium, Tissue Characterization Relaxation parameters T1 and T1ρ have shown promising results for endogenous assessment of myocardial tissue. However, mapping of the whole moving heart is challenging. This study proposes a novel free-breathing joint T1 and T1ρ mapping technique with near-isotropic spatial resolution, whole left ventricle coverage and short acquisition time of 5-6min. A diaphragmatic navigator was leveraged for prospective motion correction and retrospective motion mitigation. The T1ρ preparation module was optimized to be robust to field inhomogeneities and applicable to 3T. Phantom results indicated good accuracy of the proposed technique, and in vivo feasibility was demonstrated in healthy subjects. |
| 4007 | Computer 74
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3D whole-heart joint T1/T1ρ mapping and water/fat imaging at low-field 0.55T scanner |
| Michael G Crabb1, Karl P Kunze1,2, Carlos Castillo-Passi1,3, Camila Munoz1, Carlos Velasco1, Radhouene Neji1,2, Claudia Prieto1,3, and Rene M Botnar1,3,4 | ||
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom, 3Institute for Biological and Medical Engineering, Pontificia Universidad Catolica de Chile, Santiago, Chile, 4School of Engineering, Pontificia Universidad Catolica de Chile, Santiago, Chile |
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Keywords: Myocardium, Low-Field MRI Native T1 and T1ρ mapping has shown promising results for the detection of focal and diffuse myocardial fibrosis without requiring contrast agents. However, conventional myocardial maps are acquired sequentially in 2D at 1.5T/3T fields. 3D joint T1/T1ρ mapping has recently been proposed at 1.5T, but not demonstrated at lower field, which could potentially make cardiac MRI more accessible and affordable. Furthermore, lower T1 relaxation times, reduced SAR and fewer B0/B1 inhomogeneities make low-field MRI an attractive alternative for joint T1/T1ρ mapping. Here, we investigate the feasibility of novel 3D whole-heart joint T1/T1ρ mapping on the latest 0.55T MR scanner generation. |
| 4008 | Computer 75
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Texture analysis of area-at-risk based on T1-mapping associated with infarct characteristics following acute STEMI |
| Jiali Wang1, Kai Xu1, Chunfeng Hu1, Yankai Meng1, Shuguang Han1, Peng Wu2, Lu Han2, and Yongzhou Xu3 | ||
1The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China, 2Philips Healthcare, Shanghai, China, 3Philips Healthcare, Guangzhou, China |
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Keywords: Myocardium, Ischemia, T1 mapping To assess the potential of texture analysis (TA) of area-at-risk (AAR) based on native T1 mapping in predicting the severity of injury in ST-segment elevation myocardial infarction (STEMI) patients. Cine, T1 mapping, and late gadolinium enhancement (LGE) images were analyzed to evaluate cardiac function, and scar characteristics. The predictive value of TA for adverse LV remodeling (ALVR) and large final infarct size was evaluated. Entropy and uniformity (parameters of TA) in AAR of T1 mapping were highly correlated with convalescent infarct size, uniformity independently predicted large final infarct size, however, TA of AAR was not associated with convalescent ALVR. |
| 4009 | Computer 76
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Cardiac MR Susceptibility-weighted Imaging Detects Intramyocardial Hemorrhage of Acute Myocardial Infarction: comparison with T1 / T2 mapping |
| Jinyang Wen1, Lu Huang1, Xiaoyue Zhou2, and Liming Xia1 | ||
1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology., Wuhan, Hubei, China, China, 2MR Collaboration, Siemens Healthineers Ltd., Shanghai, China, China |
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Keywords: Myocardium, Myocardium, Susceptibility-weighted Imaging Diagnosis of intramyocardial hemorrhage (IMH) in ST-segment elevation myocardial infarction (STEMI) patients following reperfusion treatment is critical for determining prognosis. This study investigated the feasibility of susceptibility-weighted imaging (SWI) to detect IMH in STEMI patients that underwent reperfusion therapy by comparing the diagnostic performance and image quality with T1/T2 mapping. SWI showed excellent diagnostic performance in detecting IMH among STEMI patients that underwent reperfusion treatment and was comparable with T1/T2 mapping. SWI is a sensitive technique to accurately diagnose IMH in STEMI patients following reperfusion treatment. |
| 4010 | Computer 77
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Novel myocardial T1 analysis robust to transient longitudinal relaxation due to irregular heart rate variability in PCTIP |
| Yuta Endo1, Sanae Takahashi1, Haruna Shibo1, Kuninori Kobayashi1, Makoto Amanuma1, and Shigehide Kuhara1 | ||
1Department of Medical Radiological Technology, Faculty of Health Sciences, Kyorin University, Tokyo, Japan |
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Keywords: Myocardium, Relaxometry, Myocardial T1 mapping, PCTIP Myocardial T1 mapping by polarity-corrected inversion time preparation (PCTIP) is expected to reduce measurement underestimation compared to the MOLLI method. However, measurement precision is reportedly reduced, especially for heart-rate variability. We devised an analysis to overcome this problem in PCTIP and showed that it improved measurement accuracy at high heart rates. Conventional analysis has difficulty fitting to this complex T1 relaxation, resulting in less accurate and precise measurement of longer T1. T1 analysis of PCTIP using the proposed analysis showed the potential to achieve accurate and precise T1 measurements, even for irregular heart rate variability. |
| 4011 | Computer 78
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T1 mapping and extracellular volume for evaluating myocardial fibrosis in animal models with ischemia with non-obstructive coronary artery |
| Zilong Ren1, Didi Wen2, Jianxiu Lian3, Jiantao Liu3, Zhe Huang3, and Minwen Zheng4 | ||
1Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China, 2Department of Radiology, Xijing Hospital, Forth Military Medical University, Xi'an, China, 3Philips Healthcare China, Xi'an, China, 4Xijing Hospital, Fourth Military Medical University, Xi'an, China |
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Keywords: Cardiomyopathy, Animals To investigate whether T1 mapping and extracellular volume (ECV) can be used as predictors of myocardial fibrosis for ischemia with non-obstructive coronary artery disease (INOCA). Results showed pigs models with INOCA had higher native T1 mapping and ECV (mean native T1 mappingnormal = 1068.3 ± 111.5 ms, mean native T1 mappingINOCA = 1291.7 ± 109.2 ms, P = 0.018; mean ECVnormal = 23.0 ± 1.7 %, mean ECVINOCA = 46.6 ± 10.4 5, P = 0.006). T1 mapping technology could be a noninvasive way for assessing the myocardial fibrosis for INOCA models. |
| 4012 | Computer 79
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The diagnostic value of multi-parameter CMR for early detection of light-chain amyloidosis from hypertension cardiomyopathy patients |
| Fang Wang1, Lili Yang1, Yanbin Yang1, Xiaowei Ruan1, Rui Wang1, and Xiuzheng Yue2 | ||
1Peoples hospital of ningxia hui autonomous region, Yinchuan, China, 2Philips Healthcare, Beijing, China, Beijing, China |
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Keywords: Cardiomyopathy, Cardiomyopathy, CMR, light chain amyloidosis, hypertension cardiomyopathy The value of cardiac magnetic resonance imaging in diagnosing light chain amyloidosis has been confirmed, and its characteristic LGE manifestations are an important means to identify myocardial amyloidosis. However, early-stage light-chain amyloidosis patients always have the same symptoms as hypertensive cardiomyopathy in clinical practices. This study aimed to investigate the combined diagnostic efficacy of T1mapping, ECV, and myocardial strain techniques in early myocardial amyloidosis by comparing with healthy controls and patients with hypertensive cardiomyopathy that also caused uniform myocardial thickening. |
| 4013 | Computer 80
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Cardiac MRI including myocardial T2 mapping for the differentiation of AL and ATTR amyloidosis |
| Dmitrij Kravchenko1,2, Alexander Isaak1,2, Narine Mesropyan1,2, Claus Christian Pieper1, Daniel Kuetting1,2, Leon M. Bischoff1, Ulrike Attenberger1, and Julian Luetkens1,2 | ||
1Diagnostic and interventional radiology, University Hospital Bonn, Bonn, Germany, 2Quantitative Imaging Laboratory Bonn, Bonn, Germany |
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Keywords: Myocardium, Cardiomyopathy Cardiac amyloidosis can be visualized on CMR, but to date no reliable imaging parameters exist to distinguish the two most common forms of cardiac amyloidosis, AL and ATTR. Retrospective analysis of 37 cardiac amyloidosis patients shows that T2 times are markedly elevated in AL compared to ATTR, and in both compared to a control group of patients with other reasons for cardiac hypertrophy. Myocardial T2 mapping may be a useful CMR parameter for the differentiation of AL and ATTR cardiac amyloidosis.Keywords: amyloidosis, cardiac, MRI, CMR |
| 4130 | Computer 41
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Free-breathing, ECG-Free, Myocardial T1 Mapping: Initial Feasibility Experiments of Cardiac MR Multitasking on GE Systems |
| Xianglun Mao1, Hsu-Lei Lee2, Katerina Eyre3, Gaspar Delso4, Debiao Li2,5, Anthony G Christodoulou2,5, Matthias G Friedrich3,6, Michael Salerno7, and Martin A Janich8 | ||
1GE HealthCare, Menlo Park, CA, United States, 2Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 3Department of Radiology, McGill University Health Centre, Montreal, QC, Canada, 4GE HealthCare, Barcelona, Spain, 5Department of Bioengineering, University of California in Los Angeles, Los Angeles, CA, United States, 6Area 19, Montreal, QC, Canada, 7Departments of Medicine and Radiology, Stanford University, Stanford, CA, United States, 8GE HealthCare, Munich, Germany |
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Keywords: Myocardium, Quantitative Imaging, T1 Mapping Quantitative imaging biomarkers such as T1 are promising for assessing focal and diffuse myocardial pathologies across different sites and scanners. However, the lack of reliable T1 mapping methods across different scanner platforms reduces patient access to robust quantitative imaging. CMR Multitasking has shown promise for non-ECG and free-breathing quantitative imaging in the heart, primarily at 3T. This work is an initial feasibility study implementing the CMR Multitasking on GE 1.5T MR scanners. Radial trajectories, self-gating/training data, and the CMR Multitasking framework together provided co-registered T1 and cine maps in a 1-min, free-breathing, non-ECG CMR scan. |
| 4131 | Computer 42
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SSc primary heart involvement assessed by cardiovascular magnetic resonance imaging and explore its relationship with the skin involvement |
| Yanan Zhao1, Jianing Cui1, Xiuzheng Yue2, and Tao Li1 | ||
1Department of Radiology, The First Medical Center of PLA General Hospital, Beijing, China, 2Philips Healthcare(Beijing), Beijing, China |
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Keywords: Heart, Heart, SSc primary heart involvement, cardiovascular magnetic resonance,extracellular-volume fraction, modified Rodnan skin score Cardiac involvement is a significant cause of morbidity and mortality in subclinical systemic sclerosis (SSc). There are, however, no effective methods for detecting cardiac involvement in a general, asymptomatic SSc cohort. We aim to characterize SSc-primary heart involvement (SSc-pHI) through cardiovascular magnetic resonance (CMR), exploring the relationship between SSc-pHI and skin involvement by modified Rodnan skin score (mRSS). We found that 71% of SSC patients had Late gadolinium enhancement (LGE) fibrosis, and 75% and 46% had anomalous native T1 and extracellular-volume fraction (ECV). In addition, SSc-pHI is related to the severity of skin involvement. |
| 4132 | Computer 43
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Improving SASHA T1 precision via a deep-learning approach |
| Xiaofeng Qian1, Yingwei Fan1, Dongyue Si2, Yongsheng Jin3, Haiyan Ding2, and Rui Guo1 | ||
1Shool of Medical Technology, Beijing Institute of Technology, Beijing, China, 2Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 3Department of Infectious Diseases, The Affiliated Hospital of Yan’an University, Shanxi, China |
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Keywords: Myocardium, Machine Learning/Artificial Intelligence, SASHA SASHA with a 3-parameter fitting model has high T1 accuracy but low precision due to low SNR in saturation-recovery T1-weighted images. Alternatively, a two-parameter model could improve the precision with the penalty of losing accuracy. In this study, we developed a 1D neural network (DeepFittingNet) to predict SASHA T1 and alleviate the impaction from noise. We trained DeepFittingNet using simulation of SASHA with different Rician noise levels and tested it using in-vivo MR data. Results showed that T1 from DeepFittingNet had high precision and comparable accuracy to that of the 3-parameter fitting. |
| 4133 | Computer 44
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Improved 3T Adiabatic T2-Prep for Cardiac T2-Mapping |
| Ronald J. Beyers1 and Thomas S. Denney1 | ||
1MRI Research Center, Auburn University, Auburn University, AL, United States |
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Keywords: Myocardium, Cardiomyopathy, T2prep, Mapping, Adiabatic Cardiac T2-mapping allows quantifying myocardial edema resulting from events, such as, acute myocardial infarction, myocarditis and tako-tsubo cardiomyopathy. Many T2-mapping sequences exist in literature, however, most have design shortcuts that degrade their consistency, accuracy and prognostic value. We previously reported our sequence that T2-maps at end-systole (ES) for maximum wall thickness, minimized artifacts, and had four-point T2 curve-fits3. Here we present an improved 3T T2prep with four adiabatic pulses to eliminate prep inhomogeneity. This new 3T T2-mapping sequence produces T2maps at ES within 22 seconds breath hold. Pre-testing on phantoms and validation on healthy human volunteers demonstrated superior results. |
| 4134 | Computer 45
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Cardiac MR evaluation of a myocarditis mouse model |
| Dana C Peters1, Daniel Coman1, Peter Herman1, Jennifer M Kwan2, Hanming Zhang2, Raja Chakraborty2, Jeacy Espinoza2, Hyung Chun2, Saejong Park2, and Lauren A Baldassarre2 | ||
1Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 2Cardiovascular Medicine, Yale University, New Haven, CT, United States |
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Keywords: Inflammation, Contrast Mechanisms Tools were developed to evaluate mice models of myocarditis with cardiac MRI. Cine imaging with self-gating, T2 mapping using ECG-gated multi-spin echo acquisition, and pre- and post-contrast injection T1 mapping were employed. In twelve mice, including 4 mice models of myocarditis, normal T2 values were 19ms±2ms at 11.7T, and regions of higher T2 (25±2ms) were observed in some myocarditis mice. T1 mapping showed reduced T1 after injection of gadolinium, and regions of lower T1 in myocarditis vs. normal regions. These tools will be useful in improved characterization of myocarditis in mice. |
| 4135 | Computer 46
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Dark right ventricular blood pool on myocardial T2 mapping in dilated cardiomyopathy: a predictor of cardiac function |
| Yajuan Li1, Hui Zhou1, and Huiting Zhang2 | ||
1Department of Radiology, Xiangya Hospital Central South University, Changsha, Hunan, China, 2Scientific Marketing, Siemens Healthineers Ltd., Wuhan, Hubei, China |
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Keywords: Cardiomyopathy, Cardiovascular Although the T2 mapping is mainly used to evaluate myocardial water content, it is also sensitive to blood oxygenation levels, we found that in dilated cardiomyopathy the right ventricular dark right ventricular blood pool may affect the accurate quantification of myocardial T2 values. This study investigated the relationship between right ventricular blood pool on myocardial T2 mapping and indicators of cardiac function. |
| 4136 | Computer 47
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MRI relaxometry mapping of hearts extracted post-mortem from acute COVID-19 patients |
| El-Sayed H. Ibrahim1, Andrii Puzyrenko1, and Ivor Benjamin1 | ||
1Medical College of Wisconsin, Milwaukee, WI, United States |
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Keywords: Myocardium, COVID-19 Cardiac MRI is capable of myocardial tissue characterization using parametric mapping techniques such as T1 and T2 mappings, which are sensitive for detecting diffuse inflammation, fibrosis and edema. These techniques seem adequate for the detection of myocardial changes in COVID-19. In this study, we demonstrated the use of ex vivo MRI mapping techniques for noninvasive myocardial tissue characterization in COVID-19 patients and compared the MRI results to findings from autopsy reports. The proposed approach would allow for better understanding of COVID-19 pathophysiological effects on the myocardium through longitudinal studies that could be conducted without the need for invasive endomyocardial biopsy. |
| 4137 | Computer 48
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Relation of N-Terminal Pro–B-Type Natriuretic Peptide to Native T1 at Cardiac MRI |
| Rui Zhang1, Jianxin Guo2, Lihong Chen2, Yi Zhu3, Yanhui Hao1, and Kai Ai4 | ||
1THE FIRST AFFILIATED OF XI'AN JIAOTONG UNIVERSITY, XI'AN, China, 2THE FIRST AFFILIATED OF XI'AN JIAOTONG UNIVERSITY, XI'an, China, 3Philips Healthcare, Beijing, China, 4Philips Healthcare, Xi'an, China |
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Keywords: Heart, Body The purpose of this study was to explore the relationship and closeness between N-Terminal pro–B-Type natriuretic peptide (NT-proBNP) and native T1, so as to predict the occurrence of heart failure(HF). This retrospective study included 43 participants. Native T1 value were measured on T1 mapping images. The result reflects native T1 values correlated positively with NT-proBNP, and had high sensitivity and specificity. Native T1 has high predictive performance for HF. |
| 4138 | Computer 49
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Cardiac magnetic resonance native T1 mapping assessed different CKD stages, a polit study |
| Yating Chen1, Di Tian1, Jingyu Zhang1, and Zhiyong Li1 | ||
1Department of radiology, The first affiliated hospital of dalian medical university, Dalian, China |
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Keywords: Myocardium, Cardiovascular, Chronic kidney disease,T1mapping, cardiac magnetic resonance Chronic kidney disease (CKD) is a condition in which kidney damage or decreased kidney function persists for more than three months. Moreover, toxins inhibit myocardium leads to myocardial dysfunction and heart failure. T1 mapping, also known as longitudinal relaxation time quantitative imaging technology, is a new cardiac magnetic resonance (CMR) scanning technology, which can quantitatively evaluate myocardial T1 time and reflect changes in myocardial fibrosis.The purpose of this study is to analyze the difference and correlation between T1 value and CKD stage. |
| 4139 | Computer 50
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A preliminary comparison of multi-echo GraSE and T2 preparation-based myocardium T2 mapping |
| Yang Wu1, Peng Sun2, Zhigang Wu2, Xiaoxiao Zhang2, Jing Zhang2, and Jiazheng Wang2 | ||
1Department of Medical Imaging, Wuhan Asia General Hosipital, Wuhan, China, 2Philips Healthcare, Beijing, China |
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Keywords: Myocardium, Cardiovascular T2 mapping is a quantitative technique for measuring T2 in tissues, which is gaining popularity in the MR community, particularly for the detection of cardiac edema. There are several representative T2 mapping methods, including GraSE and T2 preparation-based schemes. However, there is still a lack of clinical experience with these T2 mapping methods. In this study, we tentatively compared the GraSE-based and T2 preparation-based methods for myocardium imaging. |
| 4140 | Computer 51
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Evaluation of right ventricular myocardial microcirculation in diabetes patients by using optimized intravoxel incoherent motion imaging |
| Shilan Li1, Jiahuan Tao1, Jing Zhang1, Kai Ai2, and Jiantao Liu2 | ||
1Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China, 2Philips Healthcare, Xi’an, China |
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Keywords: Myocardium, Diffusion/other diffusion imaging techniques, IVIM, diabetes, myocardial microcirculation, right ventricular myocardial Intra-voxel incoherent motion imaging (IVIM) can noninvasively and quantitatively evaluate myocardial microcirculation. At present, some scholars have demonstrated that IVIM can observe left ventricular myocardial microcirculation. However, due to the thickness of the right ventricular wall, IVIM imaging is difficult to assess it. This study proposed an optimized navigator-based and free-breathing acquisition scheme for cardiac IVIM. The results found that right ventricular myocardial microcirculation was impaired, pseudo-diffusion coefficient (Dfast) were significantly lower than healthy volunteers. It is helpful to monitor cardiovascular risk and evaluate prognosis. |
| 4141 | Computer 52
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The preliminary application of fully quantitative CMR myocardial perfusion in ST elevation myocardial infarction |
| Shi-hai Zhao1 and Wei-bo Chen2 | ||
1Radiology, Zhongshan Hospital Fudan University, Shanghai, China, 2Philips Healthcare, Shanghai, China |
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Keywords: Myocardium, Perfusion Fully quantitative CMR-MPI was preliminarily applied for evaluating the area at risk in patients with acute ST elevation myocardial infarction. As a result, the fully quantitative CMR-MPI provided quantitative myocardial blood flow of the infarction territories, which was correlated with the extent of Salvageable zone. |
| 4142 | Computer 53
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A clinical study using T1-mapping and ECV and late gadolinium enhancement to detect early myocardium involoved in rheumatologic diseases |
| Ying Liu1, Ping Tian1, Jianmin Zheng1, and Minwen Zheng1 | ||
1Xijing Hospital, Xi'an, China |
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Keywords: Myocardium, Quantitative Imaging Myocardial involvement is frequently observed in rheumatologic diseases but typically remains subclinical. This study aimed to detect early subclinical cardiac involvement and to investigate characteristics of myocardial involvement by cardiac MR (CMR) imaging. In 75 of 83 patients with rheumatologic diseases, elevated global native T1 and ECV values were observed. Furthermore, 51 patients showed positive segment distribution of late gadolinium enhancement, including subendocardial contrast, intramural contrast and transmural contrast. Thus, T1-mapping, ECV and late gadolinium enhancement could detect early myocardial involvement in rheumatologic diseases patients without overt LV dysfunction. |
| 4143 | Computer 54
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Association of CMR-verified diffuse myocardial fibrosis with depressed myocardial strain in HFpEF |
| Yi Zhang1 and Xiance Zhao2 | ||
1Shanghai General Hospital, Shang Hai, China, 2Philips Healthcare,, Shang Hai, China |
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Keywords: Myocardium, Quantitative Imaging HFpEF was seen approximately in half of all hospitalized patients for heart failure and is associated with a poor prognosis. Using CMR, the present study shows that the increased diffuse myocardial fibrosis was associated with the degree of impaired myocardial strain in patients with HFpEF. As diffuse fibrosis is recognized as prognostic markers and reversible. Our findings demonstrate the utility of myocardial strain in assessing patients with HFpEF. The measurement of myocardial strain could be used to inform clinicians about whether HF medications could improve the degree of diffuse myocardial fibrosis in HFpEF. |
| 4144 | Computer 55
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Predict late gadolinium enhancement using left ventricular long-axis strain in multiple myeloma with secondary cardiac amyloidosis patients |
| Mengyao Hu1, Yipei Song1, Ao Kan1, Jiankun Dai2, and Lianggeng Gong1 | ||
1the Second Affiliated Hospital of Nanchang University, Nanchang, China, 2GE Healthcare, MR Research China, Beijing, China |
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Keywords: Cardiomyopathy, MR Value, Multiple myeloma; Cardiac amyloidosis; Long-axis strain The purpose of this study was to evaluate the function of left ventricular (LV) in multiple myeloma (MM) with secondary cardiac amyloidosis (MM-CA) patients by cardiac magnetic resonance feature tracking (CMR-FT), and investigate the role of simple and fast CMR-FT long-axis strain (LAS) analysis in predicting late gadolinium enhancement (LGE). The results showed the LV function was more impaired in enhanced (LGE+) than in no-enhanced (LGE-) MM-CA patients. Among the investigated CMR-FT parameters, the LV LAS presented with best prediction efficacy of LGE. Our study indicated the simple and fast LAS may be beneficial for MM-CA patients with renal failure. |
| 4145 | Computer 56
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Global Longitudinal and Global Circumferential Strain by Speckle-Tracking Echocardiography and Feature-Tracking CMRI: Comparison with LVEF |
| Jing Liang1, Dan Mu1, Xiance Zhao2, and Xiuzheng Yue3 | ||
1Department of Radiology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, nanjing, China, 2Philips Healthcare, Shanghai, China, 3Philips Healthcare, beijing, China |
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Keywords: Atherosclerosis, Atherosclerosis Understanding the relationship between left ventricular function and ventricular aneurysmafter myocardial infarction is crucial for surgical treatment and drug therapy. The CMR feature-tracking technique can quantitatively evaluate strain changes of LV and detect myocardial dysfunction. The study aims to use CMR-FT in patients with left VA after MI to assess strain changes and evaluate the clinical value for predicting patient prognosis. We found that the LV GLS, GCS, and GRS could be used for predicting the NYHA class after MI. |
| 4146 | Computer 57
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Applications of artificial intelligence-assisted compressed sensing cardiac cine in left heart function imaging: Quality and Efficiency |
| Zijing Zhang1, Fei FENG1, Yulong Qi1, Hui Zhang1, and Guanxun Cheng1 | ||
1Peking University Shenzhen Hospital, ShenZhen, China |
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Keywords: Heart, Cardiomyopathy Cardiac magnetic resonance (CMR) imaging is the gold standard for non-invasive evaluation of cardiac structure and function. Conventional 2D segmented steady-state free precession cine imaging（Standrad-Cine）is widely used but the scanning time is long. Artificial intelligence-assisted compressed sensing（ACS）is a new technology that can reduce the scanning time and improve image quality. By comparing the image quality and left ventricular function (LVF) of CMR sequence based on Standrad-Cine and ACS-Cine, we found that the use of ACS-Cine can significantly reduce the scanning time while obtaining high-quality and accurate parameters images. |
| 4147 | Computer 58
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The predictive value of left ventricular strain analysis in myocardial infarction with ventricular remodeling |
| Jing Chen1, Xiaolin Mu2, Tianyu Ke3, and Yang Song2 | ||
1Graduate School of Dalian Medical University, Dalian Municipal Central Hospital, Dalian, China, 2The Affiliated Hospital of Dalian University of Technology, Dalian Municipal Central Hospital, Dalian, China, 3Graduate School of Dalian Medical University, Dalian Municipal Central Hospita, Dalian, China |
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Keywords: Cardiomyopathy, Ischemia, CMR-feature tracking The subtle changes of myocardial strain in patients with myocardial infarction complicated with ventricular remodeling remain unclear. We used the CMR-FT technique to investigate the degree of strain damage, the degree of scar tissue penetration and the long-term prognostic value after ventricular remodeling in 41 patients with old myocardial infarction.The results showed that the myocardial strain was of great value in quantitatively assessing the degree of myocardial damage, identifying the degree of scar tissue penetration in infarcted myocardium and predicting the long-term end events, especially GLS, which was the best predictor |
| 4148 | Computer 59
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Developing and Evaluating a Chronic Ischemic Cardiomyopathy in Swine Model by Rest and Stress CMR |
| baiyan zhuang1, Minjie Lu2, jian he3, and jing xu2 | ||
1Department of Magnetic Resonance Imaging, Key Laboratory of Cardiovascular Imaging(cultivation) , Cardiovascular imaging and intervention Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 2Department of Magnetic Resonance Imaging, Key Laboratory of Cardiovascular Imaging(cultivation) , Cardiovascular imaging and intervention Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, beijing, China, 3Department of Magnetic Resonance Imaging, Key Laboratory of Cardiovascular Imaging(cultivation) , Cardiovascular imaging and intervention Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, beijjing, China |
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Keywords: Myocardium, MR Value This preclinical study has established that chronic coronary artery stenosis can induce significant myocyte loss with modest global replacement fibrosis that leads to global LV dysfunction and varying degrees of congestive heart failure. |
| 4283 | Computer 21
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Opportunities for improved myocardial first-pass perfusion imaging at 0.55T |
| Ye Tian1, Sophia X. Cui2, Parveen Garg3, and Krishna S. Nayak1 | ||
1Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, 2Siemens Medical Solutions, Los Angeles, CA, United States, 3Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States |
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Keywords: Myocardium, Perfusion Myocardial first-pass perfusion (FPP) MRI is used in the clinic to diagnose coronary artery disease but has limited spatial resolution and coverage. Contemporary low-field scanners have the potential to provide FPP imaging with improved resolution and coverage by leveraging different acquisitions, such as spiral bSSFP. In this study, we demonstrate a time-efficient spiral bSSFP FPP pulse sequence at 0.55T and compare it with the standard Cartesian FPP in 4 healthy volunteers. Measured SNR, CNR, and myocardial boundary sharpness scores are all higher in the spiral images than in Cartesian images. |
| 4284 | Computer 22
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Cardiac diffusion MRI using Connectom scanner |
| Maryam Afzali1,2,3, Lars Mueller1,3, Sam Coveney1, Fabrizio Fasano4,5, John Evans2, Maria Engel2, Filip Szczepankiewicz6, Irvin Teh1, Erica Dall'Armellina1, Derek K Jones2, and Jürgen E Schneider1 | ||
1Leeds Institute of Cardiovascular and Metabolic Medicine, Leeds, United Kingdom, 2Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 3These authors contributed equally to this work, Leeds, United Kingdom, 4Siemens Healthcare Ltd, Camberly, United Kingdom, 5Siemens Healthcare GmbH, Erlangen, Germany, 6Medical Radiation Physics, Clinical Sciences Lund, Lund University, Lund, Sweden |
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Keywords: Heart, Diffusion Tensor Imaging, Strong gradients Cardiac diffusion Magnetic Resonance Imaging (cardiac dMRI) allows to non-invasively assess the microstructure of the heart. Cardiac motion typically necessitates the use of motion-compensated diffusion gradients. Here we report for the first time on the application of cardiac dMRI on a Connectom MR scanner with a gradient strength of 300 mT/m using a spin echo (SE) sequence with EPI readout and up to third order (M3) motion-compensated diffusion gradients. The results show the benefits of applying dMRI with higher order motion compensation in the human heart using a Connectom scanner. |
| 4285 | Computer 23
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Reproducibility of Cardiac 31P MRS at 7 T – Initial Results of a Multi-Center and Longitudinal Study |
| Stefan Wampl1, Ladislav Valkovic2, Ferenc Mozes2, Martin Meyerspeer1, and Albrecht Ingo Schmid1 | ||
1High Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, 2Oxford Centre for Clinical MR Research, RDM Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom |
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Keywords: Heart, Spectroscopy, 31P MRS To demonstrate reproducibility of cardiac 31P MR spectroscopy at 7T, three subjects were scanned on two sites in two different countries. The two sites are equipped with similar MR scanners but scanner platform versions, RF coil hardware and operators differed. The 16-channel receive array at site A provided 50% higher SNR than the 14cm single loop coil at site B, while site B achieved better linewidths, resulting in similar quality of spectral fitting. Two scan protocols were compared between the sites, both provided good reproducibility of cardiac PCr/ATP. This demonstrates the feasibility of larger multi-centre trials of cardiac MR spectroscopy. |
| 4286 | Computer 24
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Structural alterations in right ventricle of hypoxic pulmonary hypertensive rats assessed by high-resolution DTI |
| Dounia El Hamrani1, Emma Le Nezet1, Marilyne Campagnac2, Céline Ayez1, Benjamin Pere2, Christelle Guibert2, David Benoist1, and Bruno Quesson3 | ||
1IHU Liryc, Bordeaux, France, 2CRCTB U1045, Bordeaux, France, 3CRMSB UMR 5536, Bordeaux, France |
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Keywords: Cardiomyopathy, Hypertension Transgenic rats with Bmpr2 mutation is a model of heritable pulmonary arterial hypertension. This study aims to evaluate structural alterations of Bmpr2-mutants associated with a risk factor (chronic hypoxia) by high-resolution diffusion tensor imaging (DTI). Chronic increases of pressure-loading conditions appears to be poorly tolerated by the right ventricle (RV). Indeed, chronic hypoxia groups showed a hypertrophy in RV. Moreover, DTI analysis showed disturbances in RV (myofibers and sheetlets) and this more prominently at basal level in transgenic rats. Consequently, hypoxic pulmonary hypertension can induce microstructural changes and electrophysiological remodeling, which are potentiated by Bmpr2 mutation. |
| 4287 | Computer 25
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The Effect of Resolution and Voxel Size on SNR for Cardiac Diffusion Tensor Imaging |
| Ariel J Hannum1,2,3, Tyler E Cork1,2,3, Kawin Setsompop1,4, and Daniel B Ennis1,2 | ||
1Department of Radiology, Stanford University, Stanford, CA, United States, 2Division of Radiology, Veterans Administration Health Care System, Palo Alto, CA, United States, 3Department of Bioengineering, Stanford University, Stanford, CA, United States, 4Department of Electrical Engineering, Stanford University, Stanford, CA, United States |
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Keywords: Heart, Diffusion Tensor Imaging The purpose of this work is to characterize how SNR varies with slice thickness for a given in-plane resolution for cDTI. We observed that noise in cDTI is largely physiological dominated such that increasing voxel volume yields smaller gains in SNR than what is observed in a phantom. More specifically, increased slice thickness did not significantly improve cDTI metric maps for a given in-plane resolution. However, higher in-plane resolution improved MD and FA maps. Therefore, future work will evaluate the optimal in-plane resolution and slice thickness. |
| 4288 | Computer 26
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Multi-shell versus single-shell cardiac diffusion imaging |
| Nahla M H Elsaid1, Dana C Peters1, Gigi Galiana1, and Albert J Sinusas2 | ||
1Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 2Medicine (Cardiology), Yale University, New Haven, CT, United States |
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Keywords: Heart, Diffusion/other diffusion imaging techniques Myocardial infarction (MI) remains a leading cause of morbidity and death in the Western world. MI causes regional dysfunction, which places remote areas of the heart at a mechanical disadvantage resulting in long-term adverse left ventricular (LV) remodeling and congestive heart failure (CHF). While the cardiac fiber structure has been the topic of study for decades, to this day, it has not been fully understood. There is a need for a deeper understanding of the normal and pathological myocardial structure. Standard techniques using diffusion tensor imaging (DTI) which typically needs one b-value (single shell) set of data, yield poor quality data, as DTI is incapable of delineating fibers that form torsions and complex interdigitation. However, multi-shell diffusion magnetic resonance imaging (dMRI) can delineate these complex fibers. This research investigates the difference between multi-shell versus single shell on the quality of the resulting cardiac tractography applied to an ex vivo normal porcine heart. |
| 4289 | Computer 27
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Applying diffusion signal representation further than DTI improves cardiac dMRI insights |
| Justino Rafael Rodríguez-Galván1, Susana Merino-Caviedes1, David Filgueiras-Rama2, Javier Sánchez-González3, Antonio Tristán-Vega1, and Carlos Alberola-López1 | ||
1Laboratorio de Procesado de Imagen (LPI) Universidad de Valladolid, Valladolid, Spain, 2Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain, 3Philips Ibérica, Madrid, Spain |
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Keywords: Myocardium, Diffusion/other diffusion imaging techniques Diffusion MRI in the brain has undergone tremendous advances in the last two decades while cardiac and general diffusion in the body show a lower speed. As for modelling, either isotropic or diffusion tensor imaging (DTI) are, by far, the methods used outside the brain. In this abstract we intend to quantify the better modeling capabilities of higher order (HO) methods than DTI, i.e., than Gaussian distributions. We show, by means of ex-vivo diffusion in pig hearts, that non-Gaussianity is observable and that diffusion weighted images (DWI) generated out of a HO model show more closeness to reality than DTI. |
| 4290 | Computer 28
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Second-order motion compensated single-shot spin echo planar imaging sequence using Compressed SENSE: a pilot study |
| Rui Chen1, Wei Luo1, Zhigang Wu2, Yongzhou Xu2, Hui Liu1, and Zaiyi Liu1 | ||
1Radiology, Guangdong Provincial People’s Hospital, Guangzhou, China, 2Philips Healthcare China, Shenzhen, China |
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Keywords: Heart, Diffusion/other diffusion imaging techniques Cardiac diffusion weighted imaging (DWI) is a novel tool that could provide non-invasive in-vivo microstructural assessment. However, cardiac DWI remains a challenging task due to low signal-to-noise-ratio (SNR) and motion artifacts. The second-order motion compensated (M2C) could be used to decrease the motion artifacts, and Compressed SENSE could improve the SNR of the echo planar imaging (EPI) based sequences. Hence, the combination of M2C DWI and Compressed SENSE was firstly proposed in the present study. We found that M2C DWI using Compressed SENSE showed better overall image quality and higher SNR. |
| 4291 | Computer 29
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Computed DWI with 2nd Order motion Compensated DWI for Diagnosis of the Myocardial Infarction without Contrast Agents |
| Wei Luo1, Rui Chen1, Zhigang Wu2, Hui Liu1, and Zaiyi Liu1 | ||
1Department of Radiology, Guangdong Provincial People’s Hospital, Guangzhou, China, 2Philips Healthcare, Shenzhen, Ltd., Shenzhen, China |
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Keywords: Heart, Diffusion/other diffusion imaging techniques, Computed DWI Diagnosis of myocardial infarction (MI) remains challenge since it’s still difficult to quantify the infarction area, and to assess prognosis. Cardiac DWI could provide essential information for diagnosis of MI without exogenous contrast agents. Higher b-value DWI could improve the detection rate of myocardial infarction, but it is challenging for image acquisition in cardiac DWI due to low SNR and motion. The present study aimed to combine the 2nd order motion compensated diffusion with computed DWI to overcome these challenges. Results of this study indicates the combination is potentially a promising and valuable non-invasive method in detection of MI. |
| 4292 | Computer 30
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Semi-Automated Rejection of Corrupted Images in Cardiac Diffusion Tensor Imaging |
| Sam Coveney1, Chris Kelly1, Irvin Teh1, Maryam Afzali1,2, Lars Mueller1, Arka Das3, Filip Szczepankiewicz4, Derek K Jones2, Erica Dall’Armellina1, and Jurgen E Schneider 1 | ||
1Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, 2Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom, 3Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 4Medical Radiation Physics, Clinical Sciences Lund, Lund University, Lund, Sweden |
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Keywords: Heart, Diffusion Tensor Imaging Cardiac Diffusion Tensor Imaging (cDTI) is prone to imaging artefacts including distortion, signal dropout, and misregistration even after post-processing. We developed a method for image rejection based on a comparison between the observed images and the corresponding set of predicted images generated by tensor models fit to the observed data. A rejection threshold to exclude images from subsequent refitting of the tensor model can be chosen by the user with a simple graphical method. |
| 4293 | Computer 31
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Wideband bright- and black-blood late gadolinium enhancement imaging for patients with cardiac implantable electronic device |
| Pauline Gut1,2, Hubert Cochet1,3, Frederic Sacher1,4, Pierre Jaïs1,4, Matthias Stuber1,2,5, and Aurélien Bustin1,2,3 | ||
1IHU LIRYC, Electrophysiology and Heart Modeling Institute, Université de Bordeaux – INSERM U1045, Pessac, France, 2Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 3Department of Cardiovascular Imaging, Hôpital Cardiologique du Haut-Lévêque, CHU de Bordeaux, Pessac, France, 4Department of Cardiac Pacing and Electrophysiology, Hôpital Cardiologique du Haut-Lévêque, CHU de Bordeaux, Pessac, France, 5CIBM Center for Biomedical Imaging, Lausanne, Switzerland |
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Keywords: Myocardium, Tissue Characterization, Metallic device Conventional LGE PSIR provides very good contrast between healthy and scar tissue, but scar patterns may be confused with blood signal. Joint LGE bright- and black-blood imaging allows for improved scar contrast and detailed cardiac anatomy. However, many patients with cardiac implantable electronic device (CIED) do not undergo cardiac imaging due to severe hyperintensity artefacts. Here we propose a technology to image myocardial scars with unprecedent scar contrast in patients with CIED by combining bright- and black-blood SPOT imaging with wideband MRI. We showed that wideband SPOT can suppress CIED-related hyperintensity artefacts, while maintaining improved scar contrast and localization. |
| 4294 | Computer 32
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Low-dose Dobutamine Stress CMR perfusion for the Evaluation of Myocardial Microcirculation Induced by Chronic High-Altitude Hypoxia in Rats |
| Bo He1 | ||
1Radiological department, Sichuan Academy of Medical Sciences – Sichuan Provincial People's Hospital(SAMSPH), Chengdu, China |
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Keywords: Heart, Perfusion This study investigated the cardiovascular effects of altitude exposure, and determined the feasibility of stress first-pass perfusion CMR to objectively and noninvasively diagnose chronic HAH-induced microvascular changes. The results showed a significant decreased in LVEF as compared with NC animals at two time points. Our study has shown rest_RU and stress_RU were significantly lower and rest_MPI, stress_MPI and MPR were significantly higher. The pilot testing demonstrated that the feasibility of stress first-pass perfusion CMR to objectively and noninvasively diagnose chronic HAH-induced microvascular changes. |
| 4295 | Computer 33
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Characterization of Cardiac Quantitative Susceptibility Mapping (QSM) |
| Andrew Tyler1, Li Huang1, Radhouene Neji1,2, Ronald Mooiweer1,2, Pier-Giorgio Masci1, and Sébastien Roujol1 | ||
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom |
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Keywords: Heart, Susceptibility Cardiac Quantitative Susceptibility Mapping (QSM) is a promising technique for the evaluation of iron levels in the myocardium, particularly after a hemorrhagic infarction. In this abstract, we validate the accuracy of our QSM acquisition and reconstruction procedure in phantom experiments, and characterize its precision and repeatability in the myocardium in a healthy volunteer cohort. We found a strong linear relationship between the gadolinium concentration and measured susceptibility in the phantom. In vivo QSM precision and repeatability in the myocardium were 0.11±0.05 ppm and 0.02±0.02 ppm, respectively. |
| 4296 | Computer 34
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Left Ventricular Vertical Run-Length Non-Uniformity Adds Prognostic Value to MACE in Patients with ESRD |
| Tian-yi Zhang1, Peng Wu2, Lian-Ming Wu3, and Shan Mou1 | ||
1Nephrology, Shanghai Jiaotong University School of Medicine Affiliated Renji Hospital, Shanghai, China, 2Philips Healthcare, Shanghai, China, Shanghai, China, 3Radiology, Shanghai Jiaotong University School of Medicine Affiliated Renji Hospital, Shanghai, China |
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Keywords: Myocardium, Tissue Characterization, End-stage renal disease Left ventricular vertical run-length non-uniformity (VRLN) represents heterogeneity within native T1 images and reflects the extent of cardiac fibrosis. In uremic cardiomyopathy, interstitial fibrosis was found to be the major histological alteration. The aim of this study was to evaluate the prognostic value of VRLN in patients with ESRD. The primary endpoint was major adverse cardiac events (MACE). Survival analysis was calculated by Kaplan-Meier curves with log-rank test. VRLN remained associated with MACE in the multivariable model. Adding VRLN to a model containing clinical and CMR parameters significantly improved the accuracy and reclassification of the predictive model. |
| 4297 | Computer 35
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Global, segmental and layer specific analysis of myocardial involvement in Duchenne muscular dystrophy by LGE |
| Xuelin Fang1,2, Longwei Sun1, Yizhen Luo1, Guohua Liang1, Liqi Yang1, Kan Deng3, and Zhiyong Li1 | ||
1Shenzhen Children’s Hospital, shenzhen, China, 2Shantou University Medical College, shantou, China, 3Philips Healthcare, guangzhou, China |
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Keywords: Myocardium, Tissue Characterization To provide more imaging basis for early identification and prognosis evaluation of DMD-associated cardiomyopathy（DMD-CM）, we analyzed the distribution characteristics of LGE in global and regional left ventricle and the correlation between myocardial fibrosis index and cardiac function indexes in 29 boys with DMD. The range of LGE and the distribution pattern of interventricular septal involvement are related to the decrease of cardiac function. LGE is a reliable tool to identify subclinical DMD-CM and evaluate the severity of the disease. |
| 4298 | Computer 36
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Fast reconstruction of SMS bSSFP myocardial perfusion images using a combination of parallel imaging and AI-based denoising |
| Naledi Lenah Adam1, Kowalik Tomasz Grzegorz 1, Andrew Tyler1, Ronald Mooiweer1,2, Alexander Paul Neofytou1, Sarah McElroy1, Karl Kunze1,2, Peter Speier3, Daniel Stäb4, Radhouene Neji1,2, Muhummad Sohaib Nazir1, Reza Razavi1, Amedeo Chiribiri1, and Sébastien Roujol1 | ||
1School of Biomedical Engineering and Imaging Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom, 3Cardiovascular Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, 4MR Research Collaborations, Siemens Healthcare Limited, Melbourne, Australia |
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Keywords: Heart, Perfusion Simultaneous multi-slice (SMS) imaging enables high spatial coverage and resolution for myocardial perfusion imaging. We developed and evaluated a fast, noise-removing and signal-preserving SMS reconstruction approach combining parallel imaging and deep-learning and evaluated its benefit for myocardial perfusion imaging. In comparison to conventional parallel imaging reconstruction, the proposed SMS reconstruction provides improved perceived SNR and image quality (p<0.008), preserved sharpness and signal fidelity (p>0.05) in a short computation time (+20s for an entire dataset). |
| 4299 | Computer 37
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Trading Off Averages and Directions for Cardiac Diffusion Tensor Imaging |
| Tyler E. Cork1,2,3, Ariel J. Hannum1,2,3, Matthew J. Middione1,2, and Daniel B. Ennis1,2 | ||
1Radiological Sciences Laboratory, Stanford University, Stanford, CA, United States, 2Division of Radiology, Veterans Administration Health Care System, Palo Alto, CA, United States, 3Bioengineering, Stanford University, Stanford, CA, United States |
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Keywords: Myocardium, Microstructure The objective of this work was to control the total number of collected diffusion weighted images (DWI) across several different acquisition schemes to evaluate which combination of directions and averages provides the highest quality data. In vivo cDTI data was collected in volunteers (N=5) using a series of fixed duration protocols that span a range of diffusion directions and signal averages. We found that balancing the number of diffusion directions (12-20) and averages (5-3) allows for robust quantification of mean diffusivity, fractional anisotropy, and helix measurements in a fixed scan time. |
| 4300 | Computer 38
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Single-shot, Multi-TI Late Gadolinium Enhancement MRI using GRASP-Pro Reconstruction with View-Sharing and KWIC Filtering |
| Mingyue Zhao1,2, Daming Shen1,2, Lexiaozi Fan1,2, Kyungpyo Hong2, Li Feng3, Bradley D Allen2, Daniel C Lee4, and Daniel Kim1,2 | ||
1Biomedical Engineering, Northwestern University, Evanston, IL, United States, 2Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, 3BioMedical Engineering and Imaging Institute(BMEII), Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Division of Cardiology, Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States |
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Keywords: Myocardium, Tissue Characterization Late gadolinium enhancement (LGE) is the clinical standard for assessment of myocardial scarring. Current limitations of standard LGE are lengthy scan time, sensitivity to arrhythmia and/or dyspnea, and reliance of optimal inversion time (TI), which may be difficult to identify for patients with subendocardial scarring. We propose a free-breathing, single-short, multi-TI LGE approach to address the aforementioned challenges. Our results show that GRASP-Pro reconstruction with view-sharing (VS) and k-space weighted image contrast (KWIC) filtering produces multi-TI LGE images (i.e., no need for TI scout) with relatively high spatial resolution. |
| 4301 | Computer 39
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Application of cardiac diffusion imaging with second-order motion compensation and breath hold in the diagnosis of acute myocardial infarction |
| Xiaowei Ruan1, yanbing yang1, yishi wang2, and Xiuzheng yue2 | ||
1Peoples hospital of ningxia hui autonomous region, Yinchuan, China, 2Philips Healthcare, Beijing, China |
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Keywords: Heart, Cardiovascular, Heart; magnetic resonance imaging; myocardial diffusion imaging; myocardial infarction Cardiac magnetic resonance imaging can non-invasively evaluate the anatomy and function of the heart, and has been widely used in various fields of cardiovascular diseases. This study explores the diagnostic value of DWI in the evaluation of acute myocardial infarction. The preliminary results of 17 patients showed that the ADC value of infarcted myocardium was significantly reduced, and DWI had the ability to diagnose acute myocardial infarction. |
| 4302 | Computer 40
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Evaluating the myocardial fibre pattern in the equine heart using DTI: Protocol development for very a large ex-vivo sample |
| Lucy Elizabeth Kershaw1, Rachel Jago2, Jenny Reed2, and John Keen2 | ||
1Edinburgh Imaging, University of Edinburgh, Edinburgh, United Kingdom, 2The Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom |
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Keywords: Myocardium, Ex-Vivo Applications We aim to develop a protocol suitable for ex-vivo DTI of the equine heart. DTI on a large sample is challenging because this is already a low SNR technique. The main requirement for good-quality data in a formalin-fixed heart is to reduce TE as much as possible. The protocol recommendations presented here are largely common sense, but the long acquisitions required make troubleshooting extremely time consuming. We thought it important to share these findings for the benefit of other investigators |
| 4455 | Computer 21
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The Brain-Heart-Placenta Connection: Multimodal Investigation of Neurodevelopment in Mice with Congenital Heart Disease |
| Margaret Stapleton1,2, Devin Raine Everaldo Cortes2,3,4, Samuel Wyman1,2, Cody Ruck1,2, Shanim Manzoor1,2, Gabriella M Saladino1,2, George C Gabriel1, Tuan Tuan Tan1, Jiuann-Huey Lin3,5, Sebastian Ho1, Sivakama S. Bharathi6, Eric Goetzman6, Cecilia W. Y. Lo1, Anthony G Christodoulou7, and Yijen L. Wu1,2 | ||
1Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsbrugh, PA, United States, 2Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States, 3Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States, 4Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA, United States, 5Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States, 6Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States, 7Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States |
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Keywords: Heart, Fetus, Congenital Heart Disease Neurodevelopmental deficits (NDD) are a prevalent debilitating factor in patients with congenital heart disease (CHD) even after successful surgical palliation, but the etiology for NDD is not understood. Our study in a transgenic mouse model carrying causative genetic mutations found that NDD associated with CHD is not merely the consequence of compromised fetal hemodynamics, but primarily driven by intrinsic genetic factors and modulated by the placenta. Our study suggests that placental functions might potentially be a possible intervention strategy to overcome intrinsic genetic disadvantages. |
| 4456 | Computer 22
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Intra-subject repeatability and initial clinical evaluation of approximate myocardial spin-lock dispersion mapping |
| Joao Tourais1, Yidong Zhao1, Iain Pierce2, Christian Nitsche2, George D Thornton2, Mehmet Akcakaya3, Qian Tao1, Thomas A Treibel2, and Sebastian Weingartner1 | ||
1Imaging Physics, Delft University of Technology, Delft, Netherlands, 2Barts Heart Centre and Institute for Cardiovascular Science, University College London, London, United Kingdom, 3Department of Electrical and Computer Engineering and Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States |
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Keywords: Myocardium, Quantitative Imaging Approximate myocardial spin-lock (SL) dispersion mapping was obtained using simultaneous TRAFF2 and T2 mapping with good image quality and consistent repeatability among healthy subjects at 3T. Initial patient data indicates clinical feasibility and sensitivity to scar tissue, as identified by LGE. T2 and TRAFF2 are sensitive to distinct macromolecular interactions, showing differential contrast in disease. SL dispersion may exploit this and allow for isolating contrast components (e.g. chemical exchange effects). Our results suggest that these may allow for robust, complementary, and comprehensive clinical sensitivity to pathological remodeling. Future evaluation in a larger patient cohort with different myocardial injuries is warranted. |
| 4457 | Computer 23
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Framework for Characterizing in vivo Passive Myocardial Stiffness using in vivo MRI |
| Fikunwa O Kolawole1,2,3, Tyler E Cork1,2,4, Michael Loecher1,2, Vicky Y Wang1,2, Ellen Kuhl3, and Daniel B Ennis1,2 | ||
1Radiology, Stanford University, Stanford, CA, United States, 2Radiology, Veterans Administration Health Care System, Palo Alto, CA, United States, 3Mechanical Engineering, Stanford University, Stanford, CA, United States, 4Bioengineering, Stanford University, Stanford, CA, United States |
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Keywords: Myocardium, In Silico, computational modeling; inverse finite element modeling As increased passive myocardial stiffness is implicated in the etiology of many cardiac diseases, its in vivo estimation can improve management of heart disease. MRI-driven computational constitutive modeling can be used to obtain subject-specific passive myocardial stiffness. We present a method for building an in silico model to estimate subject-specific passive myocardial stiffness by combining LV geometric data derived from cine bSSFP, regional kinematics extracted from tagged MRI, and myocardial microstructure measured using in vivo cDTI. This project aims to develop a clinically translatable in vivo passive myocardial stiffness evaluation framework by integrating cardiac MRI and computational modeling. |
| 4458 | Computer 24
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Preliminary Study of CMR to Evaluate Structural and Functional Alterations of the Left Ventricle in Patients with Parkinson's Disease |
| Xun Yue1, Pengfei Peng1, and Jiayu Sun1 | ||
1Radiology Department, West China Hospital, Sichuan University, Chengdu, China |
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Keywords: Cardiomyopathy, Parkinson's Disease, Cardiac magnetic resonance,Cardiac function,Myocardial strain Parkinson's disease (PD) is the second most frequent neurodegenerative disease. Likewise, heart failure (HF) is one of the most common causes of mortality and morbidity in the world. The prevalence of HF has been found to be twice among PD patients compared with overall population regardless any other heart diseases and cardiovascular disease risk factors. Cardiac MRI is the clinically recognised gold standard for the assessment of ventricular functional parameters and myocardial histology. We have designed a study to assess the cardiac function and structure in patients with PD compared with a control group by means of cardiac magnetic resonance. |
| 4459 | Computer 25
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No separate acquisition timing scheme is necessary for the MOLLI technique when used for the post contrast cardiac T1 mapping |
| Seonghwan Yee1 | ||
1Radiology, Massachusetts General Hospital, Boston, MA, United States |
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Keywords: Heart, Relaxometry, MOLLI The modified Look-Locker imaging (MOLLI) technique, widely used in cardiac T1 mapping, requires specification of an acquisition timing scheme. For better quantification of wide range of T1 values, different acquisition schemes have been used for the prior- and post-contrast conditions. However, the strategy of having two different acquisition schemes might add complexity to the consistent management of clinical protocols, especially in a clinical environment with multiple MRI systems. Hence, a phantom experiment was performed to examine the necessity of this strategy. The results here suggest that having a separate acquisition scheme for the post-contrast condition would not be necessary. |
| 4460 | Computer 26
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Influence of Temporal Sampling on Reproducibility of Radiomics Features in Cardiac Cine MRI |
| Ann Laube1,2, Matthias Ivantsits1, Markus Hüllebrand1,3, Lennart Tautz3, Léa Ter-Minassian4, Hannu Zhang4, Patrick Doeblin2,5, Sebastian Kelle2,5, and Anja Hennemuth1,2,3,6 | ||
1Institute for Computer-assisted Cardiovascular Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany, 3Fraunhofer MEVIS, Bremen, Germany, 4Charité - Universitätsmedizin Berlin, Berlin, Germany, 5Deutsches Herzzentrum Berlin, Berlin, Germany, 6University Medical Center Hamburg-Eppendorf, Hamburg, Germany |
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Keywords: Heart, Radiomics, Reproducibility Radiomics has been applied in cardiovascular imaging with promising results. Still, the effect of imaging parameters on the reproducibility of radiomics features needs to be well understood for these to be used in clinical diagnostics. We conduct a retrospective study on short-axis cine CMR images of healthy volunteers to assess the impact of different temporal sampling parameters on the reproducibility of shape, first-order, texture, and deformation field-based features, and contextualize the findings with inter- and intra-observer variability. We find that the reproducibility of features is dependent on temporal sampling, warranting the introduction of parameter standardization for radiomics analyses. |
| 4461 | Computer 27
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Intravoxel Incoherent Motion Diffusion Weighted MR Imaging to Evaluate Myocardial Microvascular Dysfunction of Exertional Heat Illness |
| Zhang Jun1, Luo Song1, and Dou Weiqiang2 | ||
12. Department of Radiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China, 24. MR Research, GE Healthcare, Beijing, China |
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Keywords: Heart, Myocardium Purpose: To investigate the feasibility of assessing myocardial microvascular perfusion of patients with exertional heat illness (EHI) by intravoxel incoherent motion imaging. Methods: CMR-IVIM image quality was evaluated with a 3-point scale. CMR-IVIM derived parameters were analyzed and compared between EHI and HC. Receiver operating characteristic curve was used. Results: CMR-IVIM image quality were significantly improved. EHI patients showed decreased D*, decreased f values and higher D values compared to HC. f showed the most robust efficacy for detecting EHI related myocardial injury with the highest area under the curve. Conclusion: CMR-IVIM can evaluate myocardial injury of EHI patients. |
| 4462 | Computer 28
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Cardiac MRI Quantitative Analysis of Native T1 and Enhanced T1 Maps in Patients with Acute Heart Failure |
| Yanhui Hao1, Jianxin Guo2, Yi Zhu3, Rui Zhang1, Lihong Chen2, and Jiantao Liu4 | ||
1THE FIRST AFFILIATED OF XI'AN JIAOTONG UNIVERSITY, Xi'an, China, 2THE FIRST AFFILIATED OF XI'AN JIAOTONG UNIVERSITY, XI'an, China, 3Philips Healthcare, Beijing, China, 4Philips Healthcare, XI'an, China |
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Keywords: Heart, Body The purpose of this study was to investigate the predictive value of native T1 and enhanced T1 in the diagnosis of acute heart failure. Using echocardiographic ejection fraction and clinical symptoms as reference standards, The statistical results of our data showed that the native T1 value was found to have high sensitivity and specificity in predicting acute heart failure. |
| 4463 | Computer 29
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Papillary Muscle Derived Radiomic Features Facilitate LVH Detection and Improve LVH Etiology Classification |
| Qifan Lu1, Qiming Liu1, Yezi Chai1, and Meng Jiang1 | ||
1Renji Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, China |
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Keywords: Cardiomyopathy, Radiomics Detecting left ventricular hypertrophy(LVH) is common in a clinical scenario, while a precise classification of LVH etiology is quite challenging. In this study, we applied radiomics methods to LVH detection and LVH etiology classification. Innovatively, we extracted radiomic features not only from the myocardium(MYO) but also includes features from the papillary muscle(PM). After strict feature selection and analysis, we found the incorporation of PM features improves our model performance compared with models that simply use MYO features. |
| 4464 | Computer 30
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Impact of mitral valve repair on left atrial fibrosis in severe mitral valve regurgitation patients: a 3D LGE pilot follow-up study. |
| Sulayman el Mathari1, Jolanda Kluin1, Luuk Hopman2, Pranav Bhagirath2, Maurice Oudeman1, Alexander Vonk1, Steven Chamuleau2, Robert Klautz1,3, Aart Nederveen4, Pim van Ooij4, and Marco Götte2 | ||
1Cardiothoracic Surgery, AmsterdamUMC, Amsterdam, Netherlands, 2Cardiology, AmsterdamUMC, Amsterdam, Netherlands, 3Cardiothoracic Surgery, LUMC, Leiden, Netherlands, 4Radiology and Nuclear Medicine, AmsterdamUMC, Amsterdam, Netherlands |
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Keywords: Valves, Valves, Fibrosis Timing of mitral valve repair (MVR) surgery in mitral valve regurgitation (MR) patients remains a subject of debate. Assessment of left atrial (LA) fibrosis might aid to improve clinical management of these patients. We assessed LA fibrosis extent using 3-dimensional late gadolinium enhanced cardiac magnetic resonance imaging prior to and after MVR surgery in MR patients (n=6). Our data demonstrates a decrease of LA volume, while a concomitant increase in LA fibrosis was observed. Further study is required to determine the potential relation between LA fibrosis, pre- and post-operative changes and long-term clinical outcome. |
| 4465 | Computer 31
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Deep Learning Algorithm Based on LTSM for Automated Bi-Ventricle Segmentation of CMR Images |
| Lu Lin1, Difei Jiang2, Yueting Xiao2, and Yining Wang1 | ||
1Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 2Shukun (Beijing) Technology Co., Ltd, Beijing, China |
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Keywords: Heart, Heart Cardiac Magnetic Resonance(CMR) imaging is an advanced cardiovascular imaging modality to evaluate cardiac structure and function. Therefore, the accuracy of segmentation directly affects the clinical evaluation and diagnosis. In this study, we used Long Short-Term Memory(LSTM) network, proposing a novel deep learning-based model for accurate automated bi-ventricle segmentation of CMR images. |
| 4466 | Computer 32
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Magnetic Resonance Imaging of Central Vein in the diagnosis of Stuck Hemodialysis Central Venous Catheter: A Case report |
| Zhe Jin1, Ruimeng Yang1, Yongzhou Xu2, Peng Wu3, Faith Zeng4, and Xinhua Wei1 | ||
1Guangzhou First People's Hospital, Guangzhou, China, 2Philips Healthcare, Guangzhou, China, 3Philips Healthcare, Shanghai, China, 4Philips Healthcare, Nanchang, China |
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Keywords: Vessels, Rare disease, Stuck Catheter；Central Venous；Atrial Laceration The stuck central venous catheter (CVC) results from fibrin sheaths that firmly adhere the catheter to the wall of the superior vena cava or right atrium. Here, we report a patient with stuck CVC. The patient underwent preoperative magnetic resonance imaging (MRI) of the central vein to remove the catheter and then suffered intraoperative cardiac arrest with a bedside ultrasound suggesting cardiac tamponade and considered a right atrial laceration. The patient was then transferred to ICU, where he was discharged over a week later with stable vital signs, pending further surgery. The preoperative MRI features were analyzed retrospectively. |
| 4467 | Computer 33
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Utility of single breath-hold compressed sensing cine imaging in optimizing clinical cardiac magnetic resonance scanning procedure |
| Fuyan Wang1, Cailing Pu1, and Hongjie Hu1 | ||
1Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China |
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Keywords: Quantitative Imaging, Cardiovascular, compressed sensing The main goal of this study is to evaluate the practicability of a single breath-hold whole-heart coverage compressed sensing cine sequence in daily CMR examination, moreover, to optimize the scanning procedure for patients with different kinds of cardiac dysfunction. For patients, especially those are diagnosed with chronic heart failure, the single breath-hold CS cine can substantially shorten scanning time and provide reliable cardiac function parameters comparing with routine bSSFP cine. This single breath-hold CS cine sequences is recommended to be used before contrast injection because of gadolinium agent induced reduction of end-systolic/diastolic volume and image contrast. |
| 4468 | Computer 34
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Myocardial changes evaluation based on CMR imaging in patients with obstructive hypertrophic cardiomyopathy after Liwen procedure |
| Minwen Zheng1 and shuangxin li2 | ||
1Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xian, China, 2Department of Radiology, Xijing Hospital, Fourth Military Medical University, xinan, China |
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Keywords: Heart, Cardiovascular This study evaluated the structural, functional and tissue characteristic changes of myocardium in patients with hypertrophic obstructive cardiomyopathy after treated with the Liwen procedure using cardiac magnetic resonance (CMR) techniques. Compared with pre-operation, one year after treated with Liwen procedure (a new effective procedure), patients’ septal and left ventricular free wall thickness and left ventricular mass (LVM) were significantly reduced. There was no significant change in left ventricular ejection fraction (LVEF) (P>0.05). |
| 4469 | Computer 35
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Comparison of cardiac DWI with and without ZOOM by using second-order motion compensated spin echo for healthy control and HCM patients |
| Jianmin Zheng1, Yishi Wang2, Jianxiu Lian2, Yijun Li1, Ping Tian1, Ying Liu1, and Minwen Zheng1 | ||
1Xijing Hospital, Fourth Military Medical University, Xi 'an, China, 2Philips Healthcare,, Beijing, China |
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Keywords: Myocardium, Diffusion/other diffusion imaging techniques, Hypertrophic Cardiomyopathy（HCM） Hypertrophic cardiomyopathy (HCM) is a hereditary cardiomyopathy with a relatively high rate of sudden death. Diffusion-weighted imaging (DWI) is widely used for evaluating motion of water protons as one of the functional magnetic resonance imaging methods. Second-order motion-compensated spin echo (M2SE) has been applied for cardiac DWI, but there are few reports of M2SE combined with ZOOM for HCM. The results showed that both signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of ZOOM-M2SE were significantly higher than those of M2SE only, and the ADC value of hypertrophic cardiomyopathy was also significantly higher than that of healthy controls. Cardiac DWI using ZOOM-M2SE would be a more appropriate method for investigating the myocardial microenvironment in healthy and HCM subjects. |
| 4470 | Computer 36
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Radiomics-Based Classification of Severe Pulmonary Regurgitation in Patients with Repaired Tetralogy of Fallot by Cardiac Magnetic Resonance |
| Jo-Hua Peng1, Ming-Ting Wu2, Nai-Yu Pan3, Teng-Yi Huang3, Yi-Jui Liu4, Ken-Pen Weng5,6, and Hsu-Hsia Peng1 | ||
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 3Department of Electrical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan, 4Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, 5Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 6Dpartment of Pediatrics, National Yang Ming Chiao Tung University, Taipei, Taiwan |
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Keywords: Heart, Radiomics Cardiac magnetic resonance (CMR) radiomics is a novel technique for advanced cardiac image phenotyping. This study aimed to develop a radiomics-based classification model by CMR images and thereby to identify rTOF patients with severe pulmonary regurgitation (PR). In our results, the radiomics-based classification model can successfully identify rTOF patients with PR ≥25% by routine CMR cine images. The extracted features underlined the RV intracardiac flow alteration due to PR and the potential right ventricular remodeling in rTOF patients with severe PR. This radiomics-based information may be helpful in determining the appropriate timing for pulmonary valve replacement in the future. |
| 4471 | Computer 37
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Using Magnetic Resonance Spectroscopy for Metabolomic Characterization of Blood Serum in Patients with Myocardial Fibrosis |
| Leo L. Cheng1, Mark V. Füzesi1,2, Xiaoyu Wang1,3, Antonia Leist1,4, Anna-Laura M. Hasubek1,4, and Paul B. Yu5 | ||
1Molecular Pathology, Massachusetts General Hospital, Boston, MA, United States, 2Charité - Berlin University of Medicine, Berlin, Germany, 3Nanjing University, Nanjing, China, 4Julius-Maximilians-University of Würzburg, Würzburg, Germany, 5Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States |
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Keywords: Myocardium, Spectroscopy Myocardial fibrosis plays a key role in the pathological remodeling of the diseased heart. Yet, there is currently no routine screening method for it. The gold standard, histological examination, is highly invasive. Other alternatives are either costly (e.g. PET-CT, MRI) or subjective (echocardiography). Using HRMAS MRS, we analyzed blood samples from subjects diagnosed with common myocardial fibrosis (MF), amyloidosis (CA), or sarcoidosis (CS), plus controls. The identified regions of interest (ROI) and principal components (PC) enabled us to distinguish between diseased and not-diseased, and between the different disease groups. This may contribute to earlier diagnosis and increased success of treatment. |
| 4472 | Computer 38
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A priliminary evaluation of myocardialgadolinium deposition in apical hypertrophic cardiomyopathy with T1mapping |
| Hongzhi Yang1, shaoyu wang2, and Ruwu Yang1 | ||
1Xi dian group hospital, Xi'an, China, 2DI MR SMK, Siemens Healthineers, Shanghai, China |
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Keywords: Myocardium, Cardiovascular, Gd deposition In this study, we used the CMR T1mapping technique was to evaluate the correlation between T1R and gadolinium deposition in the myocardium of patients with apical hypertrophic cardiomyopathy after gadolinium enhancement. |
| 4473 | Computer 39
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Early detection of left ventricular involvement in arrhythmogenic right ventricular cardiomyopathy by Feature Tracking |
| Xuan Li1 and Jiang Wu1 | ||
1Shanxi Cardiovascular Hospital, Taiyuan, China |
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Keywords: Cardiomyopathy, Quantitative Imaging This retrospective study aimed to detect left ventricular myocardial strain by CMR-FT in ARVC patients. The 25 ARVC patients were divided into 2 subgroups: the preserved LVEF group (LVEF ≥50%, n=15) and the reduced LVEF group (LVEF <50%, n=10). The biventricular global and regional myocardial strain parameters in the radial, circumferential, and longitudinal directions were compared between ARVC and control group. ROC curve analysis showed the left ventricular basal longitudinal strain exhibited good performance in differential diagnosis between the LVEF ≥50% ARVC and the control group. In conclusion, CMR-FT can early detect left ventricular myocardial motion changes in ARVC patients. |
| 4474 | Computer 40
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Cardiac magnetic resonance T2 mapping for evaluating the degree of myocardial edema in patients with chronic kidney disease |
| Jingyu Zhang1, Di Tian1, Ziqi Xiong1, Yifan He1, and Zhiyong Li1 | ||
1The First Affiliated Hospital of Dalian Medical University, Dalian, China |
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Keywords: Heart, Kidney T2 mapping is used to assess the degree of myocardial damage in CKD patients, and T2 values increase as the glomerular filtration rate decreases in CKD patients. |
| 4675 | Computer 81
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The value of CMR feature tracking (FT) technique in quantitative assessment of left ventricular myocardial strain in cardiac amyloidosis (CA) |
| Jia Liu1, Jianxing Qiu1, Wei Li1, Jiangkai He1, Kai Zhao1, and Jianxiu Lian2 | ||
1Peking University First Hospital, Beijing, China, 2Philips Healthcare, Beijing, China |
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Keywords: Myocardium, Cardiovascular, Cardiac magnetic resonance,Feature tracking,Strain,Cardiac amyloidosis Subjects were divided into light-chain amyloidosis (AL-CA), transthyretin-related amyloidosis (ATTR-CA) and control group. CMR-FT technique was used to measure apical, middle and basal strain of left ventricle. Results showed ICC value was higher than 0.9 in all strain parameters, and meanwhile all strain parameters in AL-CA group and ATTR-CA group were lower than those in control group except for apical RS. However, there was no statistical difference between the AL-CA group's and ATTR-CA group. Strain evaluation could evaluate patients of CA, which may provide evidence for the treatment and diagnosis of CA. |
| 4676 | Computer 82
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Cine magnetic resonance images: relationship to therapeutic effect evaluation and prognosis in light-chain amyloidosis |
| Keyan Wang1, Jie Zheng2, Jing An3, and Jingliang Cheng1 | ||
1MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2Mallinckrodt Institute of Radiology, St. Louis, MO, United States, 3Siemens Healthineer, Shenzhen, China |
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Keywords: Cardiomyopathy, Myocardium The study evaluated left ventricular (LV), right ventricular (RV), and left atrial (LA) myocardial strain and heart function derived from cine magnetic resonance (MR) imaging for chemotherapeutic efficacy and predicted their prognostic value in patients with light-chain (AL) amyloidosis. Our results demonstrated that these parameters may be noninvasive imaging markers allowing assessment of the chemotherapeutic effect and may offer independent prognostic information for all-cause mortality in patients with AL amyloidosis. |
| 4677 | Computer 83
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Application of CMR-FT technique in the assessment of cardiac function and prognosis in patients with myocardial amyloidosis |
| Jianing Cui1, Tao Li1, Xiuzheng Yue2, and Chuncai Luo1 | ||
1Radiology, the First Medical center, PLA General Hospital, Beijing, China, 2Philips Healthcare, Beijing, China |
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Keywords: Heart, MR Value, cardiac magnetic resonance-feature tracking Early diagnosis of cardiac amyloidosis (CA) and accurate assessment of cardiac function is important for CA patients. LV strain and strain rate obtained by cardiac magnetic resonance-featured tracking (CMR-FT) have been developed as sensitive indicators of myocardial function. This study aimed to evaluate myocardial function in patients with CA by strain and strain rate to assess their prognostic value in patients with CA. Our data showed that strain rate could be used to assess the degree of cardiac impairment in CA and the difference with HCM providing prognostic information for all-cause mortality in CA patients. |
| 4678 | Computer 84
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MRI for the assessment of pre-treatment regional cardiac dysfunction in thoracic cancer patients |
| El-Sayed H. Ibrahim1, Antonio Sosa1, Jadranka Stojanovska2, Lindsay Puckett1, Elizabeth Gore1, and Carmen Bergom3 | ||
1Medical College of Wisconsin, Milwaukee, WI, United States, 2New York University, New York, NY, United States, 3Washington University, St Louis, MO, United States |
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Keywords: Heart, Heart Radiation therapy (RT) plays a key role in treating thoracic cancer, although the incidence of RT-induced cardiac complications could be as high as 33%. Nevertheless, characterization of baseline heart function, myocardial tissue characteristics and hemodynamic parameters in this patient population is not well elucidated, which was investigated in this study. The results revealed suboptimal cardiac function (both systolic and diastolic) and associations between different MRI cardiovascular parameters at baseline. Therefore, the condition of the cardiovascular system at baseline should be taken into consideration as a contributing factor in the development of RT-induced cardiotoxicity in thoracic cancer patients. |
| 4679 | Computer 85
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Assessment of early anthracycline-induced cardiotoxicity using segmental strain of cardiac magnetic resonance : an animal study |
| junqi liu1, qianfeng luo1, wanyin qi1, zhengyuan xiao1, xiaoyong zhang2, xingyuan kou1, and jing chen1 | ||
1The Affiliated Hospital of Southwest Medical University, Luzhou, China, 2Clinical Science, Philips Healthcare, Chengdu, China, Chengdu, China |
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Keywords: Cardiomyopathy, Cardiomyopathy This study investigated segmental strain to evaluate early anthracycline-induced cardiotoxicity on a 1.5T MR system in New Zealand rabbits models. The apical lateral wall and the anterior apical wall have a statistical difference corresponding to the pathological results in the second week. The ejection fraction showed statistical difference at the eighth week, while the global strain was not even statistically significant. The result showed that the peak segmental strain was earlier than the peak global strain and cardiac function, which may provide an effective and convenient monitoring method for chemotherapy patients. |
| 4680 | Computer 86
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Myocardial strain and strain rate reveal changes on regional cardiac function shortly post chemotherapy |
| El-Sayed H. Ibrahim1 and John Charlson1 | ||
1Medical College of Wisconsin, Milwaukee, WI, United States |
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Keywords: Heart, Cancer Anthracycline chemotherapy is the mainstay of cancer treatment. While the most important late, potentially permanent, side effect of chemotherapy is cardiotoxicity, the short-term acute effects of chemotherapy on cardiac function are not well elucidated. In this study, we used advanced cardiac MRI to assess subclinical changes in cardiac function immediately post chemotherapy treatment. The results demonstrated that strain and strain rate are sensitive imaging parameters that allow for early detection of changes in systolic and diastolic myocardial contractility immediately post chemotherapy despite slight changes in global cardiac function and tissue characterization. |
| 4681 | Computer 87
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Differences in Myocardial Strain at End-Inspiration versus End-Expiration with Remote Exposure to Secondhand Tobacco Smoke |
| Huiming Dong1, Ang Zhou1, Natalie Au2, Mehrdad Arjomandi2, and Dimitrios Mitsouras1 | ||
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Divisions of Pulmonary, Critical Care, Allergy, and Sleep Medicine and Occupational and Environmental Medicine, University of California, San Francisco, San Francisco, CA, United States |
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Keywords: Myocardium, Myocardium, Cardiopulmonary; Second-Hand Smoker Prolonged exposure to secondhand tobacco smoke (SHS) is associated with abnormal pulmonary function and cardiovascular response. In this study, we examined cardiac function in SHS-exposed participants using cardiac MR (CMR) and displacement encoding with stimulated echoes (DENSE) to determine whether the cardiac function is affected by air trapping-a hallmark of heavy past SHS exposure. We found that SHS-exposed participants had lower myocardial radial strain than unexposed participants at both end-inspiration and end-expiration imaging. Neither stroke volume nor cardiac output exhibited the decrease seen in unexposed participants at end-inspiration, but radial strain was significantly lower compared to end-expiration in SHS-exposed participants. |
| 4682 | Computer 88
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Pulmonary Hypertension Detection by Cardiac Magnetic Resonance Feature Tracking in Patients with Left Heart Failure |
| Yunling Li1, Kai Yang2, Xiuyu Chen2, Jianxiu Lian3, Yong Sun1, and Shihua Zhao2 | ||
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China, HarBin, China, 2Department of Magnetic Resonance Imaging, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Beijing, China, 3Beihang University, Beijing, China |
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Keywords: Heart, Cardiovascular, Heart failure To investigate the relationship correlation of cardiac magnetic resonance (CMR) feature tracking (FT)-derived right ventricular (RV) global longitudinal strain (RV-GLS) and RV global circumferential strain (RV-GCS) with mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR) to explore the diagnostic value of RV strain parameters in advanced left heart failure patients with pulmonary hypertension (PH). Study findings included as following: (a) CMR-FT RV-GLS and RV-GCS were independent risk factors for PH in patients with end-stage left heart disease, among all CMR imaging parameters; (b) Both RV-GCS (AUC = 0.868) and RV-GLS (AUC = 0.873) were valuable in predicting PH. |
| 4683 | Computer 89
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Analysis of segmental strain in identifying HCM with and without outflow tract obstruction |
| Jianxiu Lian1, Shengliang Liu2, Yunling Li2, Guokun Wang2, Xueying Wang2, Ye Li2, Xiaofang Xu1, and Yanming Zhao2 | ||
1Philips Healthcare, Beijing, China, 2The Second Affiliated Hospital of Harbin Medical University, Harbin, China |
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Keywords: Cardiomyopathy, Cardiomyopathy, hypertrophic obstructive cardiomyopathy, hypertrophic non-obstructive cardiomyopathy Hypertrophic cardiomyopathy (HCM) can be divided into two types according to pressure gradient of left ventricular outflow tract, which means different prognosis and risk stratification. Feature tracking technology can be used to calculate strain value in three orientations and evaluate the ability of myocardial deformation. Our results showed that strain differences can be detected between HCM and control group. Segmental strain and torsion also showed significant differential value between hypertrophic obstructive cardiomyopathy (HOCM) and hypertrophic non-obstructive cardiomyopathy (HNOCM) group.Our study may provide evidence in differentiating HOCM and HNOCM for further treatment. |
| 4684 | Computer 90
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Diagnostic value of myocardial strain for evaluating pig model in ischemia with non-obstructive coronary artery disease |
| Zilong Ren1, Didi Wen2, Jianxiu Lian3, Jiantao Liu3, Zhe Huang3, and Minwen Zheng4 | ||
1Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China, 2Department of Radiology, Xijing Hospital, Forth Military Medical University, Xi'an, China, 3Philips Healthcare China, Xi'an, China, 4Xijing Hospital, Fourth Military Medical University, Xi'an, China |
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Keywords: Myocardium, Animals To explore whether myocardial strain can predict functional changes for ischemia with non-obstructive coronary artery disease (INOCA) in animal models. Results showed pigs with INOCA had lower global circumferential strain (GCS) and global longitudinal strain (GLS) (mean GCSnormal = -20.2 ± 2.0 %, mean GCSINOCA = -16.6 ± 1.4 %, P = 0.009; mean GLSnormal = -19.6 ± 1.9 %, mean GLSINOCA = -14.5 ± 3.0 %, P = 0.027). Therefore, the results showed that the myocardial deformation decreased in pigs with INOCA, which could provide information for the therapy of INOCA patients. |
| 4685 | Computer 91
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CMR Myocardial Strain Analysis in Discriminating Obstructive Sleep Apnea-Hypopnea Syndrome Induced Heart Failure and Dilated Cardiomyopathy |
| Xiao Du1, Jian Wang1, Jian Yao1, Ruopeng Wang1, Mengyue Han1, Tiantian Yang1, YingCui Zhu1, Chenglin Xu1, Zheng Jing1, Deyue Yan1, Baijie Li1, and Xiuzheng Yue2 | ||
1Central Hospital Affiliated to Shandong First Medical University, Jinan, China, 2Philips Healthcare, Beijing, China |
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Keywords: Heart, Cardiovascular, Cardiac magnetic resonance; Obstructive sleep apnea-hypopnea syndrome; Dilated cardiomyopathy The obstructive sleep apnea-hypopnea syndrome (OSAHS) patients with heart failure and dilated cardiomyopathy (DCM) patients all show left ventricular dilatation and systolic dysfunction as the main phenomenon. Still, there are very few reports on identifying the two diseases. Herein cardiac magnetic resonance (CMR) myocardial strain technology was used to evaluate the cardiac function and myocardial structure of the OSAHS and DCM patients. The results showed that the global peak circumferential and longitudinal strains and the left ventricular myocardial mass of the DCM group were lower than the OSAHS group. This research provides reference for the identification of these two diseases. |
| 4686 | Computer 92
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Impact of malignant ventricular arrhythmia on left ventricular function in dilated cardiomyopathy patients assessed by CMR feature tracking |
| Ao Kan1, JianKun Dai2, Shuhao Li1, MengYao Hu1, and Lianggeng Gong1 | ||
1The Second Affiliated Hospital of Nanchang University, Nanchang, China, 2GE Healthcare, Beijing, China |
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Keywords: Cardiomyopathy, Cardiomyopathy, Cardiac magnetic resonance This study aiming at assessing the impact of malignant ventricular arrhythmia (VA+) on left ventricular (LV) function in dilated cardiomyopathy (DCM) patients using cardiovascular magnetic resonance (CMR) feature tracking (FT). 34 VA+ and 39 VA- (benign) DCM patients were measured with CMR cine imaging. Although the left ventricular ejection fraction was similar between these two groups, FT results showed the global longitudinal peak strain (GLS) was significantly lower in VA+ than in VA-. GLS had certain diagnostic value for differentiate VA+ and VA- in DCM patients. Glycosylated hemoglobin (HBA1c) was an independent determinant parameter for GLS in DCM patients. |
| 4687 | Computer 93
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Three-dimensional left ventricular torsion after pulmonary valve replacement in repaired tetralogy of Fallot: motion tracking analysis |
| Yurie Shirai1, Michinobu Nagao2, Atsushi Yamamoto1, Kei Inai3, Takeshi Shinkawa4, Seiko Shimizu5, and Shuji Sakai1 | ||
1Diagnostic Imaging and Nuclear Medicine, Tokyo Women’s Medical University, Shinjuku, Japan, 2Tokyo Women’s Medical University, Shinjuku, Japan, 3Pediatric Cardiology, Tokyo Women’s Medical University, Shinjuku, Japan, 4Cardiovascular Surgery, Tokyo Women’s Medical University, Shinjuku, Japan, 5Canon Medical, Chuo, Japan |
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Keywords: Heart, Cardiovascular In patients with repaired tetralogy of Fallot (TOF), pulmonary regurgitation is a frequent complication, resulting in right heart failure. Pulmonary valve replacement (PVR) should be performed before irreversible heart failure occurs. Pulmonary regurgitation disappears and RV volume decreases with PVR. Interventricular interactions are expected to improve left ventricular (LV) function, but in some cases LV function is not restored. We analyzed pre- and post-PVR cine cardiac MRI (CMR) with a motion tracking technique to quantitatively assess LV deformity in three dimensions. As a result, a decrease in preoperative LV torsion was a useful predictor of postoperative worsening LV function. |
| 4688 | Computer 94
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Using cardiac magnetic resonance imaging to assess advantages of cardiac-gated radioablation |
| Justin Poon1,2, Richard B Thompson3, Marc W Deyell4, Devin Schellenberg5, Kirpal Kohli6, and Steven Thomas2 | ||
1Department of Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 2Department of Medical Physics, BC Cancer - Vancouver, Vancouver, BC, Canada, 3Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 4Heart Rhythm Services and Centre for Cardiovascular Innovation, Division of Cardiology, University of British Columbia, Vancouver, BC, Canada, 5Department of Radiation Oncology, BC Cancer - Surrey, Surrey, BC, Canada, 6Department of Medical Physics, BC Cancer - Surrey, Surrey, BC, Canada |
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Keywords: Arrhythmia, Radiotherapy, cardiac radioablation Cardiac magnetic resonance (CMR) images and tracked left ventricle (LV) contour points were used to investigate the advantages of a cardiac-gated radioablation treatment for ventricular tachycardia. Contour points were divided into 17 segments of the LV. Individual segments were treated as hypothetical targets, and an optimal treatment window was determined where cardiac motion was minimal. Target centroid displacement and treatment area were quantified for the treatment window and the full cardiac cycle. Using a cardiac-gated radioablation treatment would allow for reduced treatment margins and minimize the dose delivered to surrounding normal tissue. |
| 4689 | Computer 95
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The evaluation of short- and mid-term effects of sleeve gastrectomy on left ventricular function in obesity: a prospective CMR study |
| Lu Tang1 and Jiayu Sun1 | ||
1Department of Radiology, West China Hospital, Sichuan University, Chengdu, China |
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Keywords: Heart, Myocardium, obesity; left ventricular function; cardiac magnetic resonance This study investigate left ventricular function of obese patients with no known heart disease who underwent laparoscopic sleeve gastrectomy (LSG) by cardiac magnetic resonance (CMR) in their short- and mid-term postoperative follow-up. We found that obese patients who underwent LSG had a significant decrease in body weight, left ventricular mass and left ventricular cavity in the short- and mid- term postoperative. In the mid-term postoperative, the left ventricular subclinical systolic dysfunction of left ventricle significantly improved. |
| 4690 | Computer 96
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Cardiovascular MRI combined with catheterization for objective assessment of cardiac function: data- and model-derived pressure-volume loops |
| Maria Gusseva1,2,3, Daniel A. Castellanos4, Tarique Hussain1, Dominique Chapelle2,3, and Radomír Chabiniok1,2,3,5 | ||
1Department of Paediatrics, UT Southwestern Medical Center, Dallas, TX, United States, 2Inria, Palaiseau, France, 3Ecole Polytechnique, Palaiseau, France, 4Department of Cardiology, Boston Children’s Hospital, Boston, MA, United States, 5Czech Technical University in Prague, Prague, Czech Republic |
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Keywords: Heart, Modelling Clinical pressure-volume data are often subjected to measurement noise. In the present work we explore the potential of a biomechanical model of the heart as a data-filtering tool. We use cardiovascular MRI volume data either simultaneously or sequentially acquired with catherization. We use time-varying elastance metrics for a quantitative comparison of data- and model-derived pressure-volume loops (PV loops). Our results demonstrate that the biomechanical model provides high quality PV loops that could be used to replace noisy data signals. In addition, this work contributes to the increased understanding of cardiovascular MRI results. |
| 4691 | Computer 97
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A Multi-Sequence SSFP-SPGR One-Breath-Hold Cine-Tag MR – Extent of Hybrid Artifact Interference |
| Jacob Goes1,2, Vivian S Nguyen1,2, Donovan Gorre3, Timothy J Carroll3, Jihye Jang4, Marcella K Vaicik1, Jouke Smink5, Amit R Patel6, Jeremy A Silvnick2, and Keigo Kawaji1,2 | ||
1Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Medicine - Cardiology, University of Chicago Medical Center, Chicago, IL, United States, 3Radiology, University of Chicago Medical Center, Chicago, IL, United States, 4Philips, Gainesville, FL, United States, 5Philips, Best, Netherlands, 6Medicine, University of Virginia, Charlotesville, VA, United States |
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Keywords: Myocardium, Preclinical A single-breath-held (BH) cine and tag MRI offers a hybrid SSFP-SPGR contrast approach with potential to provide quantitative measures of regional myocardial wall motion. Such approaches overcome the need for inter-BH misregistration during conventional, multi-sequence acquisition. In this study, we examine the extent of artifact interferences that manifest by means of the bypassed pre-scan calibration steps for the less sensitive SPGR-tag scan. A consecutive cohort of 25 subjects that yielded ~400 cine- and tag-volumes were retrospectively analyzed to examine the prevalence of artifact, interference with motion assessment, and the rate of yielding assessable wall motion via the hybrid one-breath-hold approach. |
| 4692 | Computer 98
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Performance of compressed-sensing cardiac MR in evaluating left ventricular function: a systematic review and meta-analysis |
| Zhaozhao Wang1, Anqi Yang1, Zien Zhou2, Chi Wang3, Jing An4, and Yi He1 | ||
1Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China, 2Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 3Heart Health Research Center, Beijing, China, 4Siemens Shenzhen Magnetic Resonance Ltd., Beijing, China |
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Keywords: Heart, Heart SSFP-cine CMR imaging has been recommended to evaluate LV function and structure. However, a long scan time limited its widely application. A novel fast CS-cine CMR imaging might be an option, but its accuracy is inconclusive. Therefore, we conducted a systematic review and meta-analysis for it. We included 23 observational studies for pooling. There was no difference in LVEF, LVEDV, LVESV and LVmass, along with no heterogeneity across different subgroups by MR field intensity, breath-holding, children, and arrhythmia (all P for inter-subgroup heterogeneity <0.05). The quality of CS-cine images was acceptable and was superior to SSFP-cine images in arrhythmia patients. |
| 4693 | Computer 99
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Feasibility of Strain Encoded (SENC) MRI to Assess Cardiac Contractility on a Commercial 0.55T System |
| YINGMIN LIU1, Donel Tani2, Matthew Joseph1, Nael F. Osman2, Mahmood Khan1, Juliet Varghese1, and Orlando P. Simonetti1 | ||
1Ohio State University, Columbus, OH, United States, 2Myocardial Solutions, Inc., Morrisville, NC, United States |
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Keywords: Cardiomyopathy, Low-Field MRI, Strain In phantom, human volunteers, and an animal model, this study shows the feasibility of strain encoding (SENC) on a commercially available 0.55T low field scanner with limited gradient performance. Measured through-slice strain in a deformation phantom agrees with steady-state free precession (SSFP) cine; global strains in healthy humans fall into the normal expected range; infarcted myocardial segments in a porcine model demonstrated reduced strain. |
| 4694 | Computer 100
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Early evaluation of subclinical cardiotoxicity in HER2-positive breast cancer patients with low-moderate cardiovascular risk using MRI |
| Sainan Cheng1, Jianwei Wang1, Yawen Wang1, Linlin Qi1, Fenglan Li1, Jianing Liu1, Jiaqi Chen1, Yang Fan2, and Lizhi Xie2 | ||
1Department of Diagnostic Radiology, National Cancer Center/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 2MR Research China, GE Healthcare, Beijing, China |
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Keywords: Heart, Cardiovascular, cardiotoxicity This study explored the early cardiac changes in HER2-positive patients treated with HER2-targeted or anthracycline therapy through cardiac MRI. The results showed frequent signs of subclinical cardiotoxicity after short-term anti-cancer therapy, despite with low-moderate cardiovascular risk. T1 mapping showed the capability for early detection of pathological myocardial changes before cardiac contractile dysfunction. In HER2-positive breast cancer patients, cardiotoxicity surveillance is important and should be carefully done even with low-moderate cardiovascular risk, especially for those received anthracycline-based therapy. |
| 4695 | Computer 101
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Cardiac energetic deficit in a rat model of Heart Failure with Preserved Ejection Fraction (HFpEF) |
| James A Goodman1, James D Quirk2, Xia Ge2, Yao Zhang1, and Rachel Roth-Flach1 | ||
1Pfizer, Inc, Cambridge, MA, United States, 2Washington University in St. Louis, St. Louis, MO, United States |
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Keywords: Cardiomyopathy, Cardiovascular, energetics Cardiac energetics in patients with heart failure with preserved ejection fraction (HFpEF) may serve as a useful biomarker of disease status and therapeutic intervention. To evaluate the potential suitability of this endpoint as a biomarker in preclinical research, we assessed cardiac energetics in the ZSF1 obese rat model of HFpEF and ZSF1 lean control. This preclinical HFpEF model exhibited similar cardiac energetic deficits as do humans with HFpEF, indicating that that the PCr/γATP ratio may be a useful translational biomarker of disease status and intervention. |
| 4696 | Computer 102
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Probing Mitochondrial Dysfunction in Mouse Hearts with Doxorubicin-Induced Cardiotoxicity Using Ungated 4D Oxy-wavelet MRI |
| Devin Raine Everaldo Cortes1,2,3, Margaret C. Stapleton2,3, Kristina E. Schwab4,5, Noah W. Coulson2,3, Elizabeth Mazzella2,3,6, Dalton R West2,3, Thomas Becker-Szurszewski3,7, Sean Hartwick3,4, Anthony G. Christodoulou8, and Yijen L Wu1,2,3,7 | ||
1Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, United States, 2Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States, 3Rangos Research Center Small Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, 4Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, 5Department of Pediatrics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, United States, 6Department of Chemistry, Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA, United States, 7Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States, 8Biomedical Imaging Research Institue, Cedars-Sinai Medical Center, Los Angeles, CA, United States |
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Keywords: Heart, Toxicity, 4D fMRI, Doxorubicin, cardiomyopathy Cardiomyopathy caused by anti-cancer anthracyclines, such as Doxorubicin (Dox), is one major cause for long-term morbidity and mortality among cancer survivors. Patients can develop cardiomyopathy leading to heart failure decades after successful cancer treatment with Dox. There is an urgent need for early detection of sub-clinical pathogenesis of Dox-induced cardiotoxicity for early intervention before irreversible cardiac tissue damage occurs. Cellular mechanistic investigations showed that mitochondrial dysfunctions are central to the Dox-induced cardiotoxicity. We have developed a time-and-motion-resolved 4D Oxy-wavelet MRI capable of detecting early Dox-induced mitochondrial dysfunction in the heart before irreversible myocardial damage occurred. |
| 4697 | Computer 103
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Cine T2 mapping reveals cardiac cycle-dependent T2 variability in cardiomyopathy |
| Michinobu Nagao1, Masami Yoneyama2, Yasuhiro Goto1, Isao Shiina1, Kazuo Kodaira1, Mana Kato1, Yasutomo Katsumata2, Yurie Shirai1, Atsushi Yamamoto1, Akiko Sakai1, Risako Nakao1, and Shuji Sakai1 | ||
1Tokyo Women's Medical University, Tokyo, Japan, 2Philips Japan, Tokyo, Japan |
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Keywords: Cardiomyopathy, Inflammation We have successfully developed cardiac cine imaging to project T2 values using T2prep-based T2 mapping with dynamic multiple trigger-delay framework. We have demonstrated that diastolic T2 values on cine T2 mapping are temporarily prolonged in patients with non-ischemic cardiomyopathy and impaired left ventricular function. Cine T2 mapping is a new noninvasive in vivo imaging technique for myocardial edema that provides an effective means of elucidating the pathogenesis of cardiomyopathy. |
| 4698 | Computer 104
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Cardiac Power to Mass Assessment by MRI in Patients with Hypertrophic Cardiomyopathy and Normal Ejection Fraction |
| Li Qing1, Zhou Zhen1, Gao Yifeng1, Ke Jiang2, and Lei Xu1 | ||
1Beijing Anzhen Hospital, Beijing, China, 2Philips Healthcare, Beijing, China, Beijing, China |
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Keywords: Cardiomyopathy, Cardiomyopathy, cardiac power; hypertrophic cardiomyopathy; ejection fraction Cardiac power (CP) output in patients with heart failure has been studied, while its importance in hypertrophic cardiomyopathy (HCM) patients is yet unclear. 99 HCM patients and 65 gender- and age-matched controls with cardiac MR were included in the study. HCM patients showed significantly higher CP (p=0.031) but lowered NCP (p<0.001) than the controls. The correlation analysis of NCP and functional parameters revealed that NCP was inversely correlated with LV mass (R=-0.395, p<0.001) in HCM patients. NCP decreased significantly in HCM patients and may continue to deteriorate with increasing LV mass. |
| 4699 | Computer 105
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Reverse Remodeling of Left Atrium Assessed by Cardiac MR Feature Tracking in Hypertrophic Obstructive Cardiomyopathy after Septal Myectomy |
| Shujuan Yang1 and Shihua Zhao1 | ||
1Fuwai Hospital, Beijing, China |
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Keywords: Cardiomyopathy, Surgery Eighty-eight patients with hypertrophic obstructive cardiomyopathy(HOCM) who received CMR before and after myectomy were retrospectively studied. Thier Pre- and postmyectomy left atrial (LA) parameters derived from CMR-feature tracking were compared. Patients with HOCM after septal myectomy showed LA reverse remodeling with a reduction in LA size and restoration in LA reservoir and booster function but unchanged LA conduit function. Among volumetric and functional changes, booster function had the greatest improvement postoperatively. Besides, preoperative LAVmin index and ΔLVOT might be potential factors associated with the degree of improvement in εa. |
| 4700 | Computer 106
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Global Longitudinal Strain Associates with Adverse Outcomes in Nonischemic Dilated Cardiomyopathy without Myocardial Scar |
| Xiaorui Xiang1, Xiuyu Chen1, and Shihua Zhao1 | ||
1Fuwai Hospital and National Center for Cardiovascular Diseases, Beijing, China |
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Keywords: Cardiomyopathy, Cardiomyopathy Despite late gadolinium enhancement (LGE) have already proved a strong association with adverse outcomes in non-ischemic dilated cardiomyopathy (NIDCM) patients, for those who with negative LGE, mortality remains a clinical issue. This study therefore aimed to investigate the prognostic impact of cardiac magnetic resonance (CMR) feature tracking derived strain in NIDCM patients without myocardial scar. |
| 4701 | Computer 107
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Differential diagnosis for hypertrophic cardiomyopathy and hypertensive heart disease by layer-specific CMR strain analysis |
| Ningning Song1, Weibin Dai1, Tingting Liu1, Yueyou Peng1, Qianyu Hu1, Kunkun Liu1, Tianfeng Shi1, Donglian Du1, Xiaoqiong Li1, Yueluan Jiang2, and Yanfeng Meng1 | ||
1Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China, 2Siemens Healthineers Ltd., Beijing, China |
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Keywords: Heart, Cardiomyopathy This study evaluated the left ventricle (LV) and right ventricle (RV) layer-specific (endocardium=Endo, epicardium=Epi, myocardium=Myo) strain of hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD). We also evaluated the ability of left atrium (LA) to differentiate HCM and HHD. The strain and strain rate were calculated from CMR. The difference of LV between HCM and HHD was endocardium. The difference of RV was free wall epicardium. The difference of LA was LA strain at conduit phase (LAS-cd). Combining the LV global circumferential strain rate of endocardium (GCSR-Endo) and LASR-cd can better differentiate HCM and HHD. |
| 4702 | Computer 108
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Full cardiac cycle coverage T2* mapping detects early myocardial changes in hypertrophic cardiomyopathy |
| Oumaima Laghzali1,2, Sandra Lehmann1,3, Joao dos Santos Periquito1, Andreas Pohlmann1, Lucie Carrier4,5, Thoralf Niendorf1,2,6, Sonia Waiczies1, and Min-Chi Ku1,2 | ||
1Berlin Ultrahigh Field Facility (B.U.F.F), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany, 3Technische Universität Berlin, Berlin, Germany, 4Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 5DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany, 6Experimental and Clinical Research Center, Charite Medical Faculty and the Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany |
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Keywords: Cardiomyopathy, Tissue Characterization, Tissue remodeling Most cases of hypertrophic cardiomyopathy (HCM) are detected at a stage when the heart has experienced significant damage. The aim of this study is to detect subtle changes in the myocardium before the appearance of overt symptoms of HCM. We show that myocardial T2* mapping can detect early changes throughout the full heart cycle in a HCM mouse model that represents the human genetic heart disease. This could potentially provide a biomarker for early stages of HCM that might be useful for non-invasive diagnoses. |
| 4703 | Computer 109
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Heart Failure with Normal Natriuretic Peptide Levels and Preserved Ejection Fraction: A Prospective Clinical and CMR study |
| Jian He1, Wenjing Yang1, Kelvin Chow2, Jing An3, and Minjie Lu1 | ||
1Fuwai hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 2Siemens Healthineers, Los Angeles, CA, United States, 3Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China |
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Keywords: Heart, Heart The predisposed HFpEF has relatively unique clinical and CMR features, which indicates it may be an important subtype or precursor of HFpEF. However, the specific clinical significance of these features requires further prognostic studies. |
| 4704 | Computer 110
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CMR-based Personalizing Risk Stratification for Outcomes in Dilated Cardiomyopathy: A Single-center Prospective Study. |
| Di Zhou1, Kelvin Chow2, Jing An3, and Minjie Lu1 | ||
1Fuwai hospital, Beijing, China, 2Siemens Healthineers SHS AM NAM USA DI MR COLLAB, Los Angeles, CA, United States, 3Siemens Shenzhen Magnetic Resonance Ltd. SHS DI MR R&D SZN DL, Shenzhen, China |
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Keywords: Cardiomyopathy, Cardiomyopathy In this study, we explored individual weight of CMR metrics for predicting short-term outcomes in DCM. ECV fraction performed excellent potential of clinical translation for prognosis in patients with DCM. LGE has better prognostic value than other CMR metrics for SCD and aborted SCD. LV strain may contribute to predict advanced heart failure, which not aid to the risk stratification of SCD. In this way, we developed a risk stratification model based on cardiac MR imaging including NYHA functional class, left ventricular ejection fraction, late gadolinium enhancement, and mean extracellular volume. It may improve clinical assessment and individual decision making. |
| 4705 | Computer 111
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Right ventricular strain for the diagnosis and prognosis of arrhythmogenic right ventricular cardiomyopathy |
| Zhixiang Dong1 and Shihua Zhao1 | ||
1Fuwai Hospital, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular, Beijing, China |
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Keywords: Cardiomyopathy, Quantitative Imaging, arrhythmogenic right ventricular cardiomyopathy To find out the values of strain parameters in the diagnosis and prognosis of arrhythmogenic right ventricular cardiomyopathy (ARVC), 247 patients with initial diagnosis of suspected ARVC were included in this study. Results showed that right ventricular global longitudinal strain (RV GLS) had moderate to high discriminatory power to identify patients with different likelihood of ARVC. Besides, patients with reduced RV GLS had a higher estimated cumulative incidence of combined cardiovascular events. These findings indicate that cardiac magnetic resonance feature tracking could potentially be used as a preferred imaging method in the first visit and follow-up of ARVC. |
| 4706 | Computer 112
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Fractal Analysis: Left Ventricular Trabecular Complexity Cardiac MRI Adds Independent Risks for HFpEF in Participants with ESRD |
| Tian-yi Zhang1, Peng Wu2, Lian-Ming Wu3, and Shan Mou1 | ||
1Nephrology, Shanghai Jiaotong University School of Medicine Affiliated Renji Hospital, Shanghai, China, 2Philips Healthcare, Shanghai, China, Shanghai, China, 3Radiology, Shanghai Jiaotong University School of Medicine Affiliated Renji Hospital, Shanghai, China |
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Keywords: Cardiomyopathy, Tissue Characterization The aim of this study was to measure left ventricular (LV) trabecular complexity by fractal dimension (FD) in patients with end-stage renal disease (ESRD), and assess whether FD is an independent risk predictor for heart failure with preserved ejection fraction (HFpEF) in this population. We found that LV mean basal FD was an independent predictor for HFpEF in the multivariate analysis. Adding LV mean basal FD to the baseline model resulted in a higher C-index and significant NRI, indicating better discriminatory ability to HFpEF en ESRD patients. |
| 4707 | Computer 113
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From Survival to Survivorship: Cardiac MRI and Serum Biomarkers of Early Detection and Therapy for Doxorubicin-Induced Cardiotoxicity in Mice |
| Margaret Caroline Stapleton1,2, Elizabeth Mazzella1,3, Noah Coulson1,2, George Cater4, Kristina Schwabb5,6, Sean Hartwick5,6, Thomas Becker-Szurszewski5,6, Devin Rain Everaldo Cortes1,2,7, and Yijen L. Wu1,2 | ||
1Department of Developmental Biology, University of Pittsburgh, Pittsburgh, PA, United States, 2Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States, 3Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, United States, 4St. Clair Hospital, Pittsburgh, PA, United States, 5Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh PA, Pittsburgh, PA, United States, 6Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States, 7Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA, United States |
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Keywords: Cardiomyopathy, Toxicity Anthracycline, like Doxorubicin (DOX), induced cardiotoxicity is a major cause of morbidity among childhood cancer survivors. Prior clinical studies diagnose using isolated measures of cardiac function, but by the time cardiotoxicity is detected, irreversible damage has already occurred. We hypothesize that multi-parametric cardiac MRI (CMR), and concurrent treatment with cardioprotective agents is a more sensitive biomarker for early diagnosis of DOX-induced cardiotoxicity. We identified DOX cardiotoxicity by CMR derived LV strain and Luminex biomarker analysis prior to any decrease in EF and SV. Our study suggests multi-parametric CMR with concurrent cardioprotective treatment can be a surrogate endpoint for therapeutic efficacy. |
| 4708 | Computer 114
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Cardiac PET-MRI to measure cardiac efficiency access Alginate intramyocardial injections in a porcine heart failure model |
| Mehrzad Tartibi1, Uttam Shrestha2, Youngho Deo3, Grant Gullberg4, Christopher T. Nguyen5, Vahid Ravanfar3, Qizhi Fang3, and Randall J. Lee3 | ||
1DelBeat, Berkeley, CA, United States, 2University of California San Francisco, San Francisco, CA, United States, 3University of California, San Francisco, San Francisco, CA, United States, 4Lawrence Berkeley National Laboratory, Berkeley, CA, United States, 5Cleveland Clinic, Cleveland, OH, United States |
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Keywords: Cardiomyopathy, Heart, Hear efficiency Nearly 70% of heart attacks (myocardial infarctions, MI) cases lead to a condition known as heart failure (HF), where the left ventricle (LV) remodels. Previous alginate and stem cell intramyocardial injection studies reported mixed outcomes using the LV global volumetric function and local myocardium mechanical response (strains and stresses)1,2. Such measures involve unvalidated assumptions yielding erroneous results3. We conducted a swine HF study treated with a particular alginate intramyocardial injection; however, instead of using the mechanical response, we directly measured the metabolic energy consumed by the myocardium before and after treatment using Positron emission tomography–magnetic resonance images (PET-MRI)4. |
| 4709 | Computer 115
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The Evaluation of Treatment Effects on Left Ventricular Structure and Function in Primary Aldosteronism by Cardiac Magnetic Resonance Imaging |
| Lu Tang1, Jens Wetzl2, Xiaoyue Zhou3, Yan Ren4, and Jiayu Sun1 | ||
1Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, 2MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, 3MR Collaboration, Siemens Healthineers Ltd, Shanghai, China, 4West China Hospital, Sichuan University, Chengdu, China |
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Keywords: Myocardium, Cardiovascular, cardiac magnetic resonance imaging; left ventricle; primary aldosteronism; strain; dysfunction This study used routine cardiac function parameters and strain parameters based on cardiac magnetic resonance imaging to evaluate the effects of specific treatments on left ventricular structure and function in patients with PA. We found that patients with PA had lower LV volumes and myocardial mass, as well as improved circumferential and longitudinal myocardial motion both after adrenalectomy and drug treatment. Specific treatment in patients of PA can not only effectively relieve the clinical symptoms, but also improve left ventricular structure and subclinical dysfunction. |
| 4710 | Computer 116
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Cardiovascular magnetic resonance findings in Danon disease：A case series of a big family |
| Xiaolong Liu1, Zhanguo Sun1, Ning Zhai1, and Xiuzheng Yue2 | ||
1Department of Radiology, Affiliated Hospital of Jining Medical University, Jining, China, 2Philips Healthcare (Beijing), Beijing, China |
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Keywords: Heart, Myocardium Heart involvement is the leading cause of death of Danon disease (DD). However, the cardiac magnetic resonance (CMR) features of DD are not well understood. Hence, we present seven DD patients with from the same family with follow-up since 2017. In our cohort, the typically CMR features of DD were left ventricle (LV) hypertrophy, late gadolinium enhancement of LV, diminished strain, and preserved or reduced LV ejection fraction. Late gadolinium enhancement most commonly involves the LV free wall and the right ventricle insertion points. Moreover, these CMR changes in male patients appeared earlier and more significant, and progressed faster. |
| 4711 | Computer 117
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Entropy as a Novel Predictor of Cardiovascular Events in Patients with Left Ventricular Noncompaction |
| Yan Gao1, Mengxiao Liu2, Zhiguo Ju3, and Ximing Wang4 | ||
1Department of Radiology, Shandong Provincial Hospital, Shandong University, Jinan, China, 2Siemens Healthineers, Shanghai, China, 3College of Medical Imaging, Shanghai University of Medicine & Health Science, Shanghai, China, 4Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China |
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Keywords: Myocardium, Heart The prognosis of LVNC is remarkably heterogeneous, with heart failure (HF), ventricular arrhythmias (VAs) and systemic embolisms (SEs) being the most frequent cardiovascular complications but no specific recommendations are available at present. In the present study, we aimed to investigate whether LV entropy could efficiently predict major adverse cardiac events (MACEs) in patients with LVNC incremental to established clinical and imaging risk markers. |
| 4712 | Computer 118
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Subendocardial Involvement as an Underrecognized LGE Subtype Related to Adverse Outcomes in Hypertrophic Cardiomyopathy |
| Shujuan Yang1 and Shihua Zhao1 | ||
1Fuwai Hospital, Beijing, China |
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Keywords: Cardiomyopathy, Heart In a retrospective cohort study, 497 consecutive HCM patients with LGE confirmed by cardiac MR were collected. The risk of cardiovascular events increases with per percentage increase in LGE extent in HCM patients with extensive LGE (>15%). While instead of LGE extent, the subendocardium-involved LGE pattern, an underrecognized phenotype in HCM, is related to the adverse outcomes in patients with non-extensive LGE (<15%), especially for heart failure-related outcomes. RVIP LGE is commonly seen in HCM, but this LGE location does not merit a prognostic value. |
| 4713 | Computer 119
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Endogenous contrast T1ρ CMR: a novel technology for differential diagnosis between cardiac amyloidosis and hypertrophic cardiomyopathy |
| Keyan Wang1, Jie Zheng2, Jing An3, and Jingliang Cheng1 | ||
1MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2Mallinckrodt Institute of Radiology, St. Louis, MO, United States, 3Siemens Healthineer, Shenzhen, China |
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Keywords: Myocardium, Cardiomyopathy This study evaluated a cardiac T1ρdispersion mapping technique, termed as myocardial fibrosis index (mFI), to distinguish cardiac amyloidosis (CA) from hypertrophic cardiomyopathy (HCM). Our data showed that mFI is significantly superior to native T1 and contrasts medium-derived extracellular volume in the differential diagnosis of CA and HCM. |
| 4830 | Computer 61
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Predictive value of total ischemic time and T1 mapping after emergency PCI in acute ST-segment elevation myocardial infarction |
| Jiali Wang1, Kai Xu1, Chunfeng Hu1, Yankai Meng1, Shuguang Han1, Yuan Lu1, Peng Wu2, Lu Han2, and Yongzhou Xu3 | ||
1The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China, 2Philips Healthcare, Shanghai, China, 3Philips Healthcare, Guangzhou, China |
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Keywords: Myocardium, Ischemia, T1 mapping ST-segment elevation myocardial infarction (STEMI) remains a major cause of morbidity and mortality worldwide, effective risk stratification is crucial for the management of STEMI. This study sought to investigate the predictive value of total ischemic time (symptom onset to balloon, S2B), native T1 and extracellular volume (ECV) in STEMI patients undergoing primary percutaneous coronary intervention (PCI). We found regardless of microvascular obstruction (MVO) or not, ECV in myocardial infarction (ECVMI) was significantly correlated with S2B time, while native T1 was not. In the 4-month follow-up, ECVMI was independently associated with final larger infarct size in multivariable regression analysis. |
| 4831 | Computer 62
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Radiomics of non-contrast bSSFP cine short axis images performs better with end-systolic images in distinguishing infarct and control subjects |
| Tom Dresselaers1,2, Baptiste Vande Berg1, Sofie Tilborghs3,4, Alexandru Cernicanu5, and Jan Bogaert1,2 | ||
1Radiology, UZ Leuven, Leuven, Belgium, 2Dept. of Imaging and Pathology, KU Leuven, Leuven, Belgium, 3Department of Electrical Engineering (ESAT), KU Leuven, Leuven, Belgium, 4Medical Imaging Research Center, UZ Leuven, Leuven, Belgium, 5Philips Benelux, Eindhoven, Netherlands |
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Keywords: Heart, Radiomics Several studies suggest that radiomics of non-contrast cine balanced steady-state free precession (bSSFP) images allows to detect myocardial infarct patients. Relevant radiomic features vary however without clear knowledge of the underlying causes. Most studies rely on time consuming manual contouring on use end-diastolic images while it was shown that features vary through the heart cycle. In this study we show that radiomics of end-systolic images result in a higher classification accuracy than for end-diastolic images and produce the same result when relying on commercial automated contouring. |
| 4832 | Computer 63
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Fully automated 16- and 32-segmentation quantitative perfusion CMR in detection of obstructive coronary artery disease |
| Sonia Borodzicz-Jazdzyk1,2, Roel Hoek1, Caitlin Vink1, Luuk Hopman1, Mark Hofman3, Yvemarie Somsen1, Ruben de Winter1, Paul Knaapen1, Mitchel Benovoy4, and Marco Gotte1 | ||
1Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands, 21st Chair and Department of Cardiology,, Medical University of Warsaw, Warsaw, Poland, 3Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Amsterdam, Netherlands, 4Area19 Medical Inc, Montreal, QC, Canada |
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Keywords: Atherosclerosis, Perfusion Recently, a fully automated QP CMR workflow has been established, which provides measures of stress MBF according to a 32-segmentation model with subdivision into endo- and epicardial subsegments. We compared the diagnostic accuracy of QP CMR according to the standard AHA 16-segment model (16M-QP) and the newly developed automated 32-segment model (32M-QP) with conventional visual assessment in patients who underwent adenosine stress perfusion CMR imaging followed by invasive coronary angiography and/or coronary computed tomography angiography. Our preliminary data have not shown superiority of diagnostic accuracy of 16M-QP or 32M-QP in comparison to visual assessment of adenosine stress first-pass perfusion imaging. |
| 4833 | Computer 64
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Delays in first medical contact to primary interventional therapy and left ventricular remodeling in myocardial infarction |
| Jiali Wang1, Kai Xu1, Chunfeng Hu1, Yankai Meng1, Shuguang Han1, Yuan Lu1, Peng Wu2, Lu Han2, and Yongzhou Xu3 | ||
1The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China, 2Philips Healthcare, Shanghai, China, 3Philips Healthcare, Guangzhou, China |
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Keywords: Myocardium, Ischemia Early reperfusion and early evaluation of cardiac adverse left ventricular remodeling (ALVR) have become important aspects of treatment for ST-segment elevation myocardial infarction (STEMI) post-percutaneous coronary intervention (PCI). The aim of this study was to investigate the predictive value of emergency medical service (EMS) delays on the severity of myocardial injury in STEMI patients after PCI. Cardiac magnetic resonance (CMR) cine, myocardial strain, and scar characteristics were analyzed. The first medical contact to balloon (FMC2B) time was recorded. FMC2B time > 90 min led to poor recovery of cardiac function and was an independent predictor of ALVR. |
| 4834 | Computer 65
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Based on cardiovascular magnetic resonance imaging for predicting right ventricular dysfunction in STEMI patients by Machine learning |
| Yanan Zhao1, Jianing Cui1, Xiuzheng Yue2, Sicong Huang2, Yun Kang2, and Tao Li1 | ||
1Department of Radiology, The First Medical Center of PLA General Hospital, Beijing, China, 2Philips Healthcare(Beijing), Beijing, China |
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Keywords: Heart, Heart, right ventricular dysfunction; machine learning techniques; ST-Segment-Elevation myocardial infarction In clinical work, right ventricular (RV) dysfunction has been ignored in acute ST-Segment-Elevation myocardial infarction (STEMI) patients. And previous studies have shown the interaction between left ventricular (LV) and RV. The aim of this study was to assess RV function by cardiovascular magnetic resonance feature tracking (CMR-FT) and to explore what factors affect RV dysfunction by machine learning techniques. The results showed that the incidence of RV dysfunction was 32.28% in STEMI patients and the occurrence of RV dysfunction was associated with RV end-systolic volume index, LV ejection fraction (EF), and interventricular septum radial strain by machine learning technique. |
| 4835 | Computer 66
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Non-enhanced Multi-contrast 3D Whole-heart MRI for Assessment of Reperfusion Injury in Patients with Acute Myocardial Infarction |
| Xin Liu1, Lu Liang1, Jing An2, Chen Zhang3, Karl-Philipp Kunze4, Radhouene Neji4, René M Botnar5, Claudia Prieto5, and Qi Yang1 | ||
1Radiology, Beijing Chaoyang Hospital, Beijing, China, 2Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, 3China MR Scientific Marketing, Siemens Healthineers, Beijing, China, 4MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom, 5School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom |
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Keywords: Myocardium, Myocardium Bright- and black-blood MRI sequences provide multi-contrast information for myocardial assessment in patients with acute ST-segment-elevation myocardial infarction (STEMI). A free-breathing 3D whole-heart bright-blood and black-blood phase sensitive (BOOST) inversion recovery sequence has been recently proposed for a simultaneous multi-contrast high-quality depiction of cardiac and vascular structures without contrast agent injection. In this study, we applied this sequence to visualize reperfusion injury in 10 patients with STEMI. Good agreement in microvascular obstruction (MVO) and intramyocardial hemorrhage (IMH) visualization was observed between the proposed approach and traditional 2D imaging methods in patients, promising potential integration into clinical treatment workflow. |
| 4836 | Computer 67
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Predictive value of myocardial strain on myocardial infarction size in ST-segment elevation myocardial infarction with preserved LVEF |
| Bin Li1,2, Guohai Su1,2, Qiang Wang1, Jian Wang3, Xiuzheng Yue4, Yingjie Ma1, Peng Wang1, Yang Li1, and Jing Tian1 | ||
1Department of Cardiology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China, 2Research Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan, China, 3Department of Radiology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China, 4Philips Healthcare, Beijing, Beijing, China |
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Keywords: Myocardium, Cardiovascular, Acute ST-segment elevation myocardial infarction With the development of the emergency system, we can see more and more acute ST-segment elevation myocardial infarction patients with preserved left ventricular ejection fraction.the predictive value of myocardial strain as determined by cardiac magnetic resonance (CMR) for myocardial infarct size could not been clarified by previous investigations in STEMI patients with preserved LVEF. The present study reveals incremental value of global circumferential strain (GCS), determined by CMR, for the prediction of infarction size after STEMI, above and beyond LVEF as well as global longitudinal strains. The findings of this study suggest that GCS may represents a potential marker of infarct size and may be used to better guide drug therapy. It may be beneficial to use GCS to determine the infarct size and prognosis of post-MI patients who do not qualify for contrast imaging. |
| 4837 | Computer 68
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Imaging reactive oxygen species and tissue iron in ischemia-reperfusion injury in swine with multimodal [18F]ROStrace PET/CT and QSM |
| Sophia Swago1, Elizabeth W. Thompson1, Annefleur Loth2, Abhijit Bhattaru3, Brianna F. Moon1, Giovanni Ferrari4, Estibaliz Castillero4, Victor A. Ferrari5, Robert Gorman6, Cory Tschabrunn7, Robert Mach3, Joel Karp3, Walter R. Witschey3, and Paco Bravo3 | ||
1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 2Amsterdam Medical Centre, University of Amsterdam (AMC-UvA), Amsterdam, Netherlands, 3Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 4Department of Surgery, Columbia University, New York City, NY, United States, 5Department of Medicine and Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, United States, 6Department of Surgery, University of Pennsylvania, Philadelphia, PA, United States, 7Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States |
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Keywords: Myocardium, Ischemia Additional myocardial injury can occur after reestablishing blood flow post ischemia. We use a multimodal protocol of sequential quantitative susceptibility mapping and positron emission tomography to directly image reactive oxygen species (ROS) and tissue iron in vivo in pig hearts after ischemic injury. We found that ROS was increased in infarct compared to remote regions of the myocardium in all animals. In an animal with microvascular obstruction, we observed an increase in susceptibility measured by QSM in the infarct region, indicating increased tissue iron, but no increased susceptibility was seen in the animals without microvascular obstruction. |
| 4838 | Computer 69
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Assessing Myocardial Microvascular Reactivity with a Novel MRI Blood-Pool Imaging Approach |
| Sadi Loai1,2, Beiping Qiang3, Michael A. Laflamme3,4,5, and Hai-Ling Margaret Cheng1,2,6 | ||
1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada, 2Translational Biology & Engineering Program, Ted Rogers Centre for Heart Research, Toronto, ON, Canada, 3McEwen Stem Cell Institute, University Health Network, Toronto, ON, Canada, 4Laboratory of Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, 5Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada, 6The Edward S. Rogers Sr. Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada |
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Keywords: Vessels, Perfusion Coronary microvascular dysfunction is driven by vascular inflammation and can go undetected for years. Current imaging diagnostics lack the ability to quantify microvascular vasomodulation, a potential biomarker for cardiac diseases dominated by microvascular disease. We propose a novel MRI approach that utilizes elevated carbon dioxide and a blood-pool contrast agent to quantify changes in microvascular blood volume. Our results confirmed hypercapnia caused strong vasodilation within female myocardium but no response in males. Transitioning from hypercapnia to room air elicited strong vasoconstriction in both sexes. This technology will be valuable for early detection of microvascular dysfunction in various diseases.
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| 4839 | Computer 70
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Do myocardial balanced steady-state free precession signal intensity curves allow to distinguish infarct patients from healthy subjects? |
| Tom Dresselaers1,2, Baptiste Vande Berg1, Sofie Tilborghs3,4, Alexandru Cernicanu5, and Jan Bogaert1,2 | ||
1Radiology, UZ Leuven, Leuven, Belgium, 2Dept. of Imaging and Pathology, KU Leuven, Leuven, Belgium, 3Department of Electrical Engineering (ESAT), KU Leuven, Leuven, Belgium, 4Medical Imaging Research Center, UZ Leuven, Leuven, Belgium, 5Philips Benelux, Eindhoven, Netherlands |
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Keywords: Myocardium, Cardiomyopathy, infarction Pre-contrast balanced steady-state free precession (bssfp) cine images seem to contain sufficient information to identify patients with an acute or chronic myocardial infarction using radiomics or deep learning methods. The reason remains however to be elucidated. It is also unclear if the cardiac phase should be considered although radiomics features vary through the heart cycle. In this study we show that the known global myocardial bssfp signal intensity variations observed in healthy subject are in fact segment dependent and have a reproducible three peak profile. In patients with acute myocardial infarct these profiles shows segment dependent alterations vs. controls. |
| 4840 | Computer 71
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Semi-automatic scar size quantification in late gadolinium enhancement of acute to chronic myocardial infarction in a porcine model scanned at 7T |
| Alena Kollmann1, David Lohr1, Maya Bille1, Maxim Terekhov1, Michael Hock1, Ibrahim Elabyad1, Florian Schnitter2, Wolfgang Bauer1,2, Ulrich Hofmann2, and Laura Maria Schreiber1 | ||
1Chair of Molecular and Cellular Imaging, Comprehensive Heart Failure Center (CHFC), University Hospital Wuerzburg, Wuerzburg, Germany, 2Department of Internal Medicine I, University Hospital Wuerzburg, Wuerzburg, Germany |
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Keywords: Myocardium, Ischemia Late gadolinium enhancement (LGE) is considered the gold standard for the quantification of scar size. We tested in a large animal model of acute and chronic infarction if clinically used methods for the assessment of infarct size (manual planimetry and several semi-automatic approaches) in LGE images are applicable to preclinical 7T LGE imaging of porcine hearts. We found excellent intra-observer reproducibility for all methods. The tested semi-automatic methods performed differently on magnitude (MAG) and phase-sensitive inversion recovery (PSIR) images. Overall, infarct sizes measured in in vivo scans showed good correlation to ex vivo LGE measurements. |
| 4841 | Computer 72
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Strain may reflect cardiac segments with high coronary artery calcium score and the risk of myocadiac ischemia |
| Xuefang Lu1, Weiyin Vivian Liu2, Guangnan Quan3, Changsheng Liu1, Yuchen Yan1, Wei Gong1, Yilin Zhao1, Zhoufeng Peng1, and Yunfei Zha1 | ||
1Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, China, 2GE Healthcare, MR Research China, Beijing, China, 3GE Healthcare, Beijing, China |
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Keywords: Myocardium, Ischemia, strain Preclinical disease is primarily assessed through the coronary artery calcium score (CACS) and used for risk assessment. Our study demonstrated that the moderate correlation of the CACS and strain, suggesting atrial or ventricular myocardium and vascular changes influence each other. In addition, there were statistically different strain values between CAD and non-CAD patients. Strain analysis for cine CMR can add functional information such as chamber wall movement on early prediction of myocardium abnormities like myocadiac ischemia and be beneficial to patients who receive one-stop check-ups for less imaging time, no contrast, and radiation-free screening. |
| 4842 | Computer 73
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New Tagging MRI Method is More Sensitive than Ejection Fraction for Assessment of Contractile Function Recovery in Infarcted Pig Hearts |
| Anna V Naumova1 and William S Kerwin1 | ||
1Radiology, University of Washington, Seattle, WA, United States |
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Keywords: Myocardium, Heart, myocardial infarction A new tagging method has been proved as a sensitive approach for assessment of regional deformation in the infarcted pig’s heart. The linear tags were placed in 60-degree pattern offsets and aligned with the AHA segments. The tagging analysis algorithm uses local Fourier transformation of the isolated spectral peaks. We have shown the temporal changes in circumferential strain of the infarcted segments of myocardium and faster recovery of myocardial strain followed by 60-min ischemia-reperfusion injury in comparison with 90-min. Circumferential strain was a more sensitive parameter for earlier detection of regional contractile dysfunction in comparison with ejection fraction. |
| 4843 | Computer 74
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Fractal Analysis of Left Ventricular Trabeculae in HFpEF Patients with Multivessel Coronary Artery Disease |
| Zi-Yi Gu1, Wei-Bo Chen2, Yong-Yi Wang1, and Lian-Ming Wu3 | ||
1Department of Cardiovascular Surgery, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China, 2Philips Healthcare, Shanghai, China, 3Department of Radiology, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China |
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Keywords: Heart, Heart, HFpEF HFpEF patients with multivessel CAD have changes in myocardial trabecular complexity. The left ventricular FD obtained with fractal analysis can reflect the complexity of myocardial trabecular and has an independent predictive value for the diagnosis of HFpEF in patients with multivessel CAD. Including FD into the diagnostic model can help improve the diagnosis. |
| 4844 | Computer 75
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Tracking lipid and macromolecular changes in Ex-vivo hearts using NOEMTR and rNOE at 7T |
| Blake Benyard1, Sophia Swago 1, Neil E. Wilson1, Paul S. Jacobs1, Walter Witschey1, Mohammed Harris1, and Ravinder Reddy1 | ||
1Center for Advanced Metabolic Imaging in Precision Medicine (CAMIPM), Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States |
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Keywords: Myocardium, Heart, CEST & MT Two ex-vivo animal hearts were scanned at 7T to track lipid and macromolecular changes using NOEMTR and rNOE. Data was acquired on a fresh lamb heart and a healthy Yorkshire swine with an anteroseptal infarct by occlusion of the left anterior descending (LAD) coronary artery. After performing a multi-pool analysis, it is demonstrated that the NOEMTR and rNOE signal decreases in the infarcted region of the swine heart compared to the normal tissue and lamb heart. |
| 4845 | Computer 76
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Vasodilator Stress Myocardial Strain in Coronary Artery Disease：An Animal Study With Histological Validation |
| Jing Xu1, Zhao Shihua1, and Minjie Lu1 | ||
1Chinese Academy of Medical Sciences & Peking Union Medical College Fuwai Hospital, Beijing, China |
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Keywords: Myocardium, Heart ATP can cause a pronounced positive inotropic effect on human heart. CMR-FT even at rest provides an excellent negative predictive value for myocardial ischemia and infarction in patients with CAD. CMR-FT is easy to perform without the need for dedicated acquisition and complex post-processing which can be applied to standard CMR cine sequences. Rest myocardial strain might be a noninvasive option serving as an additional gatekeeper for CAD patients with a needle-free test. Human studies are needed to validate these findings in a multicenter setting and to test whether CMR-FT can be incorporated into clinical guidelines. |
| 4846 | Computer 77
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1H NMR of downfield metabolites in swine heart after myocardial infarction |
| Sophia Swago1, Jacob Smothers2, Neil E. Wilson3, Mark A. Elliott3, Ravi Prakash Reddy Nanga3, Robert Gorman4, Cory Tschabrunn5, Arjun Sengupta6, Aalim Weljie6, Ravinder Reddy3, and Walter R. Witschey3 | ||
1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Chemistry, West Virginia University, Morgantown, WV, United States, 3Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 4Department of Surgery, University of Pennsylvania, Philadelphia, PA, United States, 5Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 6School of Medicine, University of Pennsylvania, Philadelphia, PA, United States |
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Keywords: Myocardium, Spectroscopy Growing interest into in vivo 1H MRS of downfield metabolites (>4.7 ppm) has necessitated greater understanding of the metabolite contributions of peaks found in the downfield. 1H NMR provides high-SNR, high-spectral resolution data that can aid in the identification of metabolite resonances. We collected downfield NMR spectra at 700 MHz from infarct and remote myocardium extract of pig hearts after myocardial infarction. We were able to assign peaks to NAD+, NADH, ATP, and AMP in the downfield region and quantified these metabolites in infarct and remote myocardium. |
| 4847 | Computer 78
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A clinical application of deep learning reconstructed LGE combined with coronary calcification scoring in coronary artery disease |
| Xuefang Lu1, Yuchen Yan1, Weiyin Vivian Liu2, Changsheng Liu1, Wei Gong1, Yan Wang1, Zhoufeng Peng1, Guangnan Quan3, and Yunfei Zha1 | ||
1Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, China, 2GE Healthcare, MR Research China, Beijing, China, 3General Electric Medical (China) Co, Beijing, China |
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Keywords: Myocardium, Machine Learning/Artificial Intelligence, late gadolinum enhancement Preclinical disease is primarily assessed through the coronary artery calcium score (CACS) and used for risk assessment, screening CACS is a reliable indicator for the assessment of coronary artery disease in our study, FWHM analysis of PSMDEDL and PSMDEO showed moderate correlation between the percentage of enhancement area and CACS, beneficial for check-up with less imaging time and low radiation screening. This finding should be further validated in a larger sample size. Moreover, threshold techniques such as 2SD to 5SD were sensitive to signal intensity and should be concerned for analysis on deep-learning reconstructed images, especially missing detection rate. |
| 4848 | Computer 79
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Comparison of 17 machine-learning models derived from LGE-MRI for predicting reverse LV remodeling in patients with STEMI |
| Jianing Cui1, Tao Li1, Xiuzheng Yue2, Sicong Huang2, Yun Kang2, and Fei Yan1 | ||
1Radiology, the First Medical center, PLA General Hospital, Beijing, China, 2Philips Healthcare, Beijing, China |
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Keywords: Heart, Heart, reverse left ventricular remodeling Radiomics is an emerging quantitative imaging method that could extract mineable high-dimensional data from medical images. We investigate the suitable models and significant radiomics features of LGE images in participants with STEMI and assess their value in predicting r-LVR. We chose 17 classification models to analyze all the adiomics features of LGE images in participants with STEMI. Our study found that the model of extra tree classifier was manifested relatively high AUC value in predicting r-LVR. The wavelet-HHH_gldm_SmallDependenceLowGrayLevelEmphasis was relatively strong predictor of r-LVR. |
| 4849 | Computer 80
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T1rho was used to monitor myocardial changes in patients with CAD |
| Yanbing Yang1, Xiuzheng YUE2, Fang Wang3, and Yishi Wang2 | ||
1People's Hospital of Ningxia Hui Autonomous Region, yinchuan, China, 2Philips Healthcare, beijing, China, 3People's Hospital of Ningxia Hui Autonomous Region, yinchaung, China |
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Keywords: Cardiomyopathy, Cardiomyopathy The current reference standard for detection of myocardial scar tissue is late gadolinium enhancement(LGE). Cardiac magnetic resonance T 1 mapping is a technique that enables quantification of extracellular volume fraction (ECV). Calculating ECV mapping need to inject gadolinium contrast agent, which may be contraindicated in some patients. For those patients, T1rho contrast may help them find the changes in myocardial because T1rho MRI has been used to detect early myocardial infraction in swine model. In this study, we used T1rho to assess myocardial changes in patients with early CHD with a view to finding Grey zone of LGE positive patients. |
| 4850 | Computer 81
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Improved self-navigation of respiratory motion in XD-GRASP reconstruction using exploratory factor analysis on 3D late gadolinium enhancement |
| Dima Bishara1,2, Kyungpyo Hong1, Suvai Gunasekaran1, Daniel C Lee1,3, Bradley D Allen1, Michael Markl1,2, Rod Passman3, and Daniel Kim1,2 | ||
1Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, 2Department of Biomedical Engineering, Northwestern University, Evanston, IL, United States, 3Department of Medicine, Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States |
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Keywords: Arrhythmia, Image Reconstruction Signal processing of self-navigation in 3D late gadolinium enhancement (LGE) with XD-GRASP reconstruction often leads to variable results due to a variety of factors including arrhythmia (variations in inversion-recovery of self-navigated signal) and bright signals around the body that are projected onto the edge profile used for tracking respiratory motion. Principal component analysis (PCA) is the conventional approach to process navigation signal. We hypothesize that exploratory factor analysis (EFA) produces better extraction of respiratory motion. Our results show that EFA improves respiratory motion tracking in 3D LA LGE obtained b-SSFP readout, but not in gradient echo [GRE] readout. |
| 4851 | Computer 82
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Left Atrial Circumferential Strain for Evaluation of Mitral Regurgitation: A Feasibility and Reproducibility Study |
| Siva Sreedhar1, Aakash Gupta2, Teodora Chitiboi3, Maurice Pradella4, and Mohammed S.M. Elbaz1 | ||
1Northwestern University Feinberg School of Medicine, Chicago, IL, United States, 2Radiology, Stanford University, Stanford, CA, United States, 3Digital Technology and Innovation, Siemens Healthineers, Erlangen, Germany, 4Cardiothoracic Radiology, University Hospital of Basel, Basel, Switzerland |
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Keywords: Myocardium, Valves, strain Short-axis CMR left atrial (LA) circumferential strain has not yet been investigated as a cardiac biomarker. This study assessed feasibility and reproducibility of LA circumferential strain in a healthy cohort, examined changes in strain within mitral regurgitation (MR) patients, and assessed correlations between reproducible strain measures and MR severity and cardiac function. Reservoir strain globally and at superior and mid LA regions was found to be reproducible, was significantly different between healthy volunteers and MR patients, and was correlated with cardiac function. CMR LA circumferential strain is reproducible with potential utility in evaluating impaired LA mechanics in MR patients. |
| 4852 | Computer 83
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Cardiac magnetic resonance imaging for preprocedural planning of percutaneous left atrial appendage closure |
| Dagmar Bertsche1, Patrick Metze1, Erfei Luo1, Tillman Dahme1, Birgit Gonzka1, Wolfgang Rottbauer1, Ina Vernikouskaya1, Leonhard Moritz Schneider1, and Volker Rasche1 | ||
1Internal Medicine II, Ulm University Medical Center, Ulm, Germany |
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Keywords: Arrhythmia, MR-Guided Interventions, LAA closere, preprocedural planning An isotropic 2D six-point Dixon method was applied for assessment of the left arterial appendix (LAA) morphology prior to LAA closure intervention. Sufficient image quality was achieved even in highly arrhythmic patients allowing for the preinterventional quantification of the LAA dimensions as required for proper closure device selection. MR derived diameters were compared to periprocedurally TEE and XR derived values, which were in good agreement. Further, optimal XR angulation providing projections perpendicular to the envisaged landing zone could be identified. |
| 4853 | Computer 84
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The relationship of epicardial adipose tissue thickness with arrhythmias in patients with hypertension: a 3.0 T cardiac magnetic resonance study |
| Zhaoxia Yang1, Dazong Tang1, Yi Luo2, Chunlin Xiang1, Lu Huang1, and Liming Xia1 | ||
1Tongji Hospital,Huazhong University of Science and Technology, wuhan, China, 2Tongji Hospital,Huazhong University of Science and Technology, Wuhan, China |
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Keywords: Heart, Hypertension, epicardial adipose tissue Cardiac MRI enables quantification of EAT thickness with good to excellent reproducibility for differentiating the hypertensive patients with arrhythmias from those without arrhythmias and normal controls. Additionally, EAT thickness was correlated with native T1 and LVMi, which demonstrated EAT might induce cardiac remodeling and promote myocardial fibrosis. Cardiac MRI-derived EAT thickness metrics has great potential to further explore the mechanism of EAT with arrhythmias and guide an appropriate treatment in patients of hypertension. |
| 4854 | Computer 85
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Impact of Epicardial Adipose Tissue Assessed on Early Left Atrial Dysfunction in Heart Failure with Preserved Ejection Fraction |
| Yunling Li1, Shengliang Liu1, Jianxiu Lian2, Goukun Wang1, Xia Gu1, Yong Sun1, and Bo Yu1 | ||
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China, HarBin, China, 2Phillips Healthcare, Beijing, China |
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Keywords: Heart, Cardiovascular, Heart failure Heart failure with preserved ejection fraction (HFpEF) characterized by heart diastolic dysfunction. Epicardial adipose tissue (EAT) has been speculated to play an important role in HFpEF pathophysiological processes. In present study, EAT volume was significantly increased in patients with HFpEF and patients with high risk for developing HFpEF compared with healthy controls, and it was correlated with CMR parameters indicative of diastolic dysfunction, particularly GLS and LA reservoir, conduit, and pump strains. These findings provided compelling evidence for the potential role of EAT in adverse myocardial remodeling and the pathophysiology of HFpEF. |
| 4855 | Computer 86
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Association between HFpEF and Impaired Left Heart strain in Hypertensive Heart Disease: Evaluation by Cardiac MRI Feature Tracking |
| Tianyu Ke1, Xiaolin Mu2, Jing Chen1, and Yang Song2 | ||
1Graduate School of Dalian Medical University, Dalian Municipal Central Hospital, Dalian, China, 2The Affiliated Hospital of Dalian University of Technology, Dalian Municipal Central Hospital, Dalian, China |
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Keywords: Heart, Hypertension, Heart failure LA/LV strain The application value of left atrial and left ventricular strain parameters to heart failure with preserved left ventricular ejection fraction in hypertensive heart disease was evaluated by cardiac magnetic resonance feature tracking technology. We found that the left atrial function, strain, and left ventricular strain parameters were impaired to varying degrees in the HFpEF-HHD group, and the left atrial ejection fraction was significantly correlated with some feature parameters of left atrial and left ventricular strain. However, NT-proBNP is only significantly correlated with LAεa.In the identification of the HFpEF-HHD population, the LASRe parameter has shown optimal diagnostic value. |
| 4856 | Computer 87
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Left Atrial Hemodynamics Assessed with 2D Real Time Phase Contrast MRI are Associated with Prior Stroke History in AF Patients |
| Justin J Baraboo1, Maurice Pradella1, Anthony Maroun1, Elizabeth Weiss1, Amanda Dicarlo1, Suvai Gunasekaran1, Daniel Lee1, Rod Passman1, Daniel Kim1, and Michael Markl1 | ||
1Northwestern, Chicago, IL, United States |
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Keywords: Arrhythmia, Velocity & Flow 2D real time phase contrast was utilized in atrial fibrillation patients with and without a prior history of stroke. To account for within patient heartbeat variability, heartbeats were aggregated within each patient according to ECG trace. Heartbeat durations (RR-intervals) were sorted from fast to slow for each patient. Three groups were formed from the tertiles of the RR-intervals (faster, regular, and slower heartbeats). Blood stasis and peak velocity were compared between the stoke subgroups for each grouping. Patients with prior stroke had significantly higher stasis which remained significant in multivariable modeling using demographic variables as well. |
| 4857 | Computer 88
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High-resolution, free-breathing, fat-suppressed 3D Late Gadolinium Enhancement to define atrial wall scar after atrial fibrillation ablation |
| Rajesh Dash1,2, Henry Chubb3, Xianglun Mao4, Fara Nikbeh4, Pingni Wang4, Yuko Tada1, Gaspar Delso5, Martin Janich6, Sanjiv Narayan1, Daniel Ennis1, and Phillip C Yang1 | ||
1Stanford University, Stanford, CA, United States, 2Cardiovascular Institute, Stanford, CA, United States, 3Stanford Lucille Packard Childrens Hospital, Stanford, CA, United States, 4GE Healthcare, Inc., Menlo Park, CA, United States, 5GE Healthcare, Inc., Barcelona, Spain, 6GE Healthcare, Inc., Munich, Germany |
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Keywords: Myocardium, Arrhythmia, atrial fibrillation, ablation, atrial wall, scar, delayed gadolinium enhancement Atrial fibrillation (AF) ablation procedures still face challenges to achieve durable restoration of sinus rhythm. Advanced cardiac MRI delayed enhancement can delineate atrial wall scar to aid in planning AF ablation. However, thin atrial walls demand more advanced sequence development. In this study, we report protocol optimizations for high-resolution, free-breathing, fat-suppressed 3D LGE to detect atrial wall scar. In three AF patients to date, we found progressive improvements in CNR and detailed the sequence modification that led to these improvements. Future iterations will be used to assess atrial scar in patients, pre- and post-AF ablation. |
| 4858 | Computer 89
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Magnetic resonance multitasking T1 mapping in atrial fibrillation |
| Chengchen Zhao1,2, Chunna Jin1,2, Xiaopeng He1,2, Simin Meng1,2, Qi Liu3, Zhongqi Zhang3, Jianzhong Sun4, and Meixiang Xiang4 | ||
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, 2Key Lab of Cardiovascular Disease of Zhejiang Province, Hangzhou, China, 3UIH America, Inc., Houston, TX, United States, 4Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China |
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Keywords: Arrhythmia, Arrhythmia CMR multitasking T1 mapping, a recently proposed free-breathing, non-ECG technique, was evaluated in atrial fibrillation patients. It demonstrated good image quality, differentiated patients from healthy participants, and correlated with important cardiac function biomarkers. It is a promising T1 mapping tool in atrial fibrillation patients. |
| 4859 | Computer 90
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Characterization of left atrial remodelling and atrial fibrillation subtype using fractal analysis of late gadolinium enhanced MRI |
| Rebecca E Thornhill1,2, Jessie Kang1,2, Pablo B Nery3,4, Calum Redpath3,4, David Birnie3,4, Sophie Chenier3, and Elena Peña1,2 | ||
1Medical Imaging, The Ottawa Hospital, Ottawa, ON, Canada, 2Radiology, Radiation Oncology, and Medical Physics, University of Ottawa, Ottawa, ON, Canada, 3University of Ottawa Heart Institute, Ottawa, ON, Canada, 4Medicine, University of Ottawa, Ottawa, ON, Canada |
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Keywords: Arrhythmia, Heart Atrial Fibrillation (AF) is a heart rhythm disorder of the left atrium (LA) that is associated with an increased risk of stroke and death. AF has been known to induce morphological changes of the LA that may be detectable with fractal analysis. The purpose of this study was to assess whether there are differences in fractal dimension of the LA based on AF severity or subtype. The paroxysmal AF groups demonstrated increased fractal dimension compared to persistent or permanent groups. LA dilatation associated with persistent or permanent AF may explain this result, but this requires validation in a larger cohort. |
| 4860 | Computer 91
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Cardiac magnetic resonance imaging with feature tracking to evaluate left atrial strain for patients with systemic lupus erythematosus |
| huang wei wei1, luo song1, zhang jun1, zhang ling yan1, and dou wei qiang2 | ||
1Jinling Hospital, Medical School of Nanjing University, nanjing, China, 2MR Research, GE Healthcare, beijing, China |
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Keywords: Cardiomyopathy, MR Value This study aimed to detect left atrial (LA) strain and left ventricular (LV) stain by cardiac magnetic resonance imaging feature tracking (CMR-FT) in patients with systemic lupus erythematosus (SLE). SLE patients showed lower LVEF and multiple LV strain data than control group. Furthermore, significantly different LA reservoir, conduit and bump function were found in SLE patients than healthy controls. With these findings, CMR-FT has proven as an effective method in the diagnosis of cardiac injury in SLE patients. |
| 4861 | Computer 92
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Cardiac MRI left ventricular and left atrial parameters predict myocardial late gadolinium enhancement in hypertrophic cardiomyopathy |
| Di Tian1, Ziqi Xiong1, Yifan He1, Jingyu Zhang1, and Zhiyong Li1 | ||
1Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China, Dalian, China |
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Keywords: Cardiomyopathy, Cardiomyopathy Myocardial fibrosis causes functional impairment in patients with hypertrophic cardiomyopathy (HCM). The clinical gold standard for imaging myocardial fibrosis is cardiac magnetic resonance imaging (MRI) with late gadolinium enhancement (LGE), which is commonly used for the diagnosis and prognostic evaluation of patients with HCM. However, LGE imaging is an invasive test and some patients have adverse reactions to contrast agents. The aim of this study is to predict the presence of fibrosis in the left ventricular myocardium by cardiac magnetic resonance (CMR) non-invasive assessment of left atrial and left ventricular parameters in patients with HCM. |
| 4862 | Computer 93
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DRA-CMR based layer-specific right ventricle strain predicts pulmonary arterial hypertension prognosis: results from a Chinese registry study |
| Wen Li1, Xianchang Zhang2, Xiaoyue Zhou3, Jens Wetzl4, Qing Gu5, and Jianguo He6 | ||
1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 2MR Collaboration, Siemens Healthineers Ltd, Beijing, China, 3MR Collaboration, Siemens Healthineers Ltd, Shanghai, China, 4Magnetic Resonance, Siemens Healthcare, Erlangen, Germany, 5Emergency Center, State Key Laboratory of Cardiovascular Disease, Key Laboratory of Pulmonary Vascular Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 6Center of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China |
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Keywords: Heart, Heart, Strain, Right ventricle This is the first study to demonstrate that right ventricle (RV) layer-specific strain rate measured by deformation registration algorithm based cardiovascular magnetic resonance had the long-term and 3-year mortality predictive values in pulmonary arterial hypertension (PAH) patients. Our findings indicated that RV layer-specific strain rate may be sensitive indicators of RV dysfunction in PAH. |
| 4863 | Computer 94
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3D LGE MRI at 3T for the Detection of Chronic Scars after RF Ablation in the Right Atrium: Assessment of Precision in a Porcine Study |
| Simon Reiss1, Enaam Chleilat2, Thomas Lottner1, Peter Kohl2, and Michael Bock1 | ||
1Division of Medical Physics, Department of Radiology, University Medical Center Freiburg, Freiburg, Germany, 2Institute for Experimental Cardiovascular Medicine, University Heart Center Freiburg Bad Krozingen, and Faculty of Medicine, University of Freiburg, Freiburg, Germany |
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Keywords: Heart, Arrhythmia RF ablation is an established treatment option for cardiac arrhythmia. After RF ablation the scar can be assessed with LGE MRI. However, imaging of scars in the right atrium (RA) remains difficult due to the small geometry. In this animal study, we assessed the conspicuity of chronic RA scars by comparing scar extent on MRI to ex vivo anatomical dissected preparations. We show, the detection of chronic RF ablation scars in the RA is feasible but with limited precision. The presented comparison to gross histology provides and important evaluation of RF ablation scar conspicuity in LGE MRI. |
| 4864 | Computer 95
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Radiomics-Based Classification of Patients with Repaired Tetralogy of Fallot by Cardiac Magnetic Resonance |
| Jo-Hua Peng1, Ming-Ting Wu2, Nai-Yu Pan3, Teng-Yi Huang3, Yi-Jui Liu4, Ken-Pen Weng5,6, and Hsu-Hsia Peng1 | ||
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 3Department of Electrical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan, 4Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, 5Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 6Dpartment of Pediatrics, National Yang Ming Chiao Tung University, Taipei, Taiwan |
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Keywords: Heart, Radiomics Radiomics is a novel technique of advanced cardiac magnetic resonance (CMR) phenotyping by analyzing a couple of variables of cardiac shape and tissue texture. This study aimed to develop the radiomics-based classification model to differentiate rTOF patients from normal controls and evaluate the representative features of ventricular and myocardial abnormalities in rTOF patients. In conclusion, the radiomics-based classification model can successfully differentiate rTOF patients from normal controls with routine CMR cine images. The selected features underlined the right ventricular remodeling and left ventricular myocardium fibrosis in rTOF patients. |
| 4865 | Computer 96
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Analysis of Biventricular and Biatrial Strain by Cardiovascular Magnetic Resonance in Dilated Cardiomyopathy |
| Shengliang Liu1, Yunling Li1, Jianxiu Lian2, Guokun Wang1, Xueying Wang1, Ye Li1, Yanming Zhao1, and Bo Yu1 | ||
1The Second Affiliated Hospital of Harbin Medical University, Harbin, China, 2Philips Healthcare, Beijing, China |
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Keywords: Cardiomyopathy, Myocardium, strain, feature tracking, fast long-axis Dilated cardiomyopathy (DCM) remains to attract worldwide attention for its poor prognosis and high mortality. The interaction of biatrial and biventricular deformation capacity in DCM patients is unclear. In this study, feature tracking and fast long-axis method were used to evaluate myocardial strain. We found that biventricular and biatrial strain were significantly impaired in DCM group than control group. LV GLS was obviously impaired in event group than no event group, and it showed significantly prognostic value in predicting cardiovascular events. Comprehensive CMR analysis should be performed to improve the diagnosis ability for DCM patients. |
| 4866 | Computer 97
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Left ventricular layer-specific strain predicts pulmonary arterial hypertension long-term prognosis |
| Wen Li1, Xianchang Zhang2, Jens Wetzl3, Qing Gu4, and Jianguo He5 | ||
1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 2MR Collaboration, Siemens Healthineers Ltd, Beijing, China, 3Magnetic Resonance, Siemens Healthcare, Erlangen, Germany, 4Emergency Center, State Key Laboratory of Cardiovascular Disease, Key Laboratory of Pulmonary Vascular Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 5Center of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China |
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Keywords: Heart, Data Processing, Strain Studies have reported left ventricular (LV) dysfunction was associated with more severe disease and poorer prognosis in pulmonary arterial hypertension (PAH). However, there are only few studies that evaluated LV strain abnormalities using cardiovascular magnetic resonance (CMR) in PAH patients. This is the first study to describe the distribution pattern and prognostic values of LV layer-specific strain/strain rate in PAH patients using a deformation registration algorithm (DRA) based on CMR. It’s found that CMR derived LV layer-specific strain could predict long-term prognosis in PAH patients. |
| 4867 | Computer 98
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Cine MRI-derived radiomics features of the blood pool in pulmonary hypertension–heart failure with preserved ejection fraction (PH-HFpEF) |
| Kai Lin1, Roberto Sarnari1, Daniel Z Gordon1, Michael Markl1, and James C Carr1 | ||
1Northwestern University, Chicago, IL, United States |
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Keywords: Heart, Radiomics, blood pool Radiomics features acquired from the blood pool in different chambers (LV/RV/LA/RA) at various periods within a cardiac cycle present diverse property in characterizing PH-HFpEF. Multiple blood pool radiomics features were significantly related to PCWP and mPAP (r: 0.4 – 0.643). Compared to the LV wall, the blood pools provide more efficient features (individual AUC: 0.7 – 0.821) to discriminate PH-HFpEF from controls (p < 0.05). Cine MRI-derived radiomics features of the blood pool can be used to characterize PH-HFpEF. Radiomics features of the blood pool have the potential to become novel quantitative imaging biomarkers for presenting cardiovascular pathology. |
| 4868 | Computer 99
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Can Radiomics Identify Severe Right Ventricular Dilation in Patients with Repaired Tetralogy of Fallot by LV Cardiac Magnetic Resonance Images? |
| Jo-Hua Peng1, Ming-Ting Wu2, Nai-Yu Pan3, Teng-Yi Huang3, Yi-Jui Liu4, Ken-Pen Weng5,6, and Hsu-Hsia Peng1 | ||
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 3Department of Electrical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan, 4Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, 5Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 6Dpartment of Pediatrics, National Yang Ming Chiao Tung University, Taipei, Taiwan |
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Keywords: Heart, Radiomics Radiomics analysis of cardiac magnetic resonance (CMR) may provide new insights into the quantitative analysis of cardiac imaging by extracting many computational quantitative metrics. This study aimed to develop a radiomics-based classification model by left ventricular (LV) CMR images to identify repaired tetralogy of Fallot (rTOF) patients with severe right ventricular (RV) dilation. In our results, the AUC were 0.81 and 0.91 for LV radiomics and LV radiomics+LV indices models, respectively. The extracted features underlined the LV intracardiac flow alteration due to RV dilation and the potential LV remodeling in rTOF patients with severe RV dilation. |
| 4869 | Computer 100
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Effect of Left Ventricular Myocardial Strain on Right Ventricle in Hypertrophic Cardiomyopathy |
| Tingting Liu1, Weibin Dai1, Yueyou Peng1, Qianyu Hu1, Kunkun Liu1, Ningning Song1, Tianfeng Shi1, Donglian Du1, Xiaoqiong Li1, Yueluan Jiang2, and Yanfeng Meng1 | ||
1Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China, 2Department of MR Scientific Marketing, Siemens Healthineers Ltd., Beijing, China |
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Keywords: Myocardium, Cardiomyopathy, Hypertrophic cardiomyopathy, Biventricular function This study evaluated the right ventricular (RV) myocardial strain of Hypertrophic Cardiomyopathy (HCM) patients with preserved ejection fraction (EF) and without myocardial hypertrophy in RV based on Cardiovascular magnetic resonance feature tracking technique (CMR-FT), and further explored the effect of left ventricular (LV) myocardial mechanics on the RV. The results showed that the global longitudinal strain (GLS) of the RV has been impaired, although the structure and EF of the RV were normal, so myocardial strain can be more sensitive and earlier to identify cardiac impairment. The systole function of the LV has a great influence on the RV function. |
| 4967 | Computer 21
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Mapping cardiac |B1+| field with B1+ prepared imaging |
| Paulina Siuryte1, Markus Henningsson2, Christal van de Steeg-Henzen3, and Sebastian Weingärtner1 | ||
1TU Delft, Delft, Netherlands, 2Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden, 3Holland PTC, Delft, Netherlands |
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Keywords: Heart, Artifacts, cardiac B1+ mapping, transmit field imaging Cardiac MRI at 3T offers gains in SNR, but is strongly affected by field inhomogeneities, including the transmit field B1+. Mapping |B1+| field around the heart is particularly challenging due to the presence of motion, and few techniques exist for robust imaging. Recently, Bloch-Siegert shift mapping was proposed for motion robust cardiac |B1+| mapping, however, it requires long echo times making it more susceptible to artifacts. Here, we introduce a new preparation module for efficient |B1+| mapping. The method shows 0.06% / 0.35% reduced noise variability in phantom and 0.61±0.35% / 0.89±0.63% in-vivo imaging, and visually improved map quality. |
| 4968 | Computer 22
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Fast continuous 3D catheter balloon tracking for MRI-guided cardiac catheterization using 1D slice projection imaging with GRE stack of slices. |
| Grzegorz Tomasz Kowalik1, Radhouene Neji1,2, Tracy Moon3, Nina Mellor3, Reza Razavi1, Kuberan Pushparajah1, and Sébastien Roujol1 | ||
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom, 3Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom |
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Keywords: Heart, MR-Guided Interventions An automated catheter tracking approach was developed for real-time continuous catheter visualization during MR-guided cardiac catheterization. 1D projection images are acquired for each slice of a stack providing fast 3D volume screening. These images are first collected in the absence of catheter to create an atlas on background signal across the breathing cycle. During catheter navigation, incoming images are matched to the best images of the atlas, which are then subtracted to suppress background signal. Finally, automated peak detection is applied to extract the catheter balloon location. The technique is successfully demonstrated during in-vitro and in one patient. |
| 4969 | Computer 23
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Cardiac MRI at 3.0T in the presence of implantable cardioverter defibrillators (ICDs) |
| Theresa Reiter1, Oliver M Weber2, Ingo Weiss3, and Wolfgang Rudolf Bauer1 | ||
1Medicine I, University Hospital Wuerzburg, Wuerzburg, Germany, 2Philips GmbH, Hamburg, Germany, 3Biotronik SE Co.KG, Berlin, Germany |
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Keywords: Myocardium, Visualization Performing a cardiac MRI in the presence of active cardiac implants remains a challenge due to the extensive artifact burden caused by the implant. Sequence solutions established at 1.5 T have yet to be transferred to a clinical use at 3T. In this work, we use phantom and volunteer measurements in order to establish an adapted 3T protocol for CINE with TFE and wideband LGE-PSIR sequences that sufficiently suppress image artifacts caused by active implants. The first clinical data show the feasibility of this protocol and its ability to detect scar tissue in patients with implanted ICD. |
| 4970 | Computer 24
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Real-time Automatic Passive Catheter Tracking During MR-guided Cardiac Catheterization |
| Rohini Vidya Shankar1, Li Huang1, Radhouene Neji1,2, Grzegorz Kowalik1, Alexander Paul Neofytou1, Ronald Mooiweer1,2, Tracy Moon3, Nina Mellor3, Reza Razavi1, Kuberan Pushparajah1, and Sébastien Roujol1 | ||
1Biomedical Engineering, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom, 3Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom |
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Keywords: Heart, MR-Guided Interventions, Tracking, Real-time MR-guided cardiac catheterization procedures currently employ passive tracking approaches to follow the gadolinium-filled catheter balloon during catheter navigation. This requires frequent manual tracking and repositioning of the imaging slice, especially when the catheter moves out-of-plane during the procedure. In this study, we developed a novel MRI guidance approach that enables automatic real-time tracking of the catheter balloon and repositioning of the imaging slice for continuous visualization of the balloon during catheter navigation. We first demonstrate the proposed approach in a phantom and subsequently present an initial evaluation in patients. |
| 4971 | Computer 25
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Quantification and evaluation of cardiac motion correction methods for hybrid PET/MRI |
| Heeseung Lim1, Benjamin Wilk1,2, Gerald Moran3, Heather Biernaski1, Jonathan D. Thiessen1,2,4, and Frank S. Prato1,2,5 | ||
1Lawson Imaging, Lawson Health Research Institute, London, ON, Canada, 2Medical Biophysics, Western University, London, ON, Canada, 3Siemens Healthcare Limited, Oakville, ON, Canada, 4Medical Imaging, Western University, London, ON, Canada, 5Physics and Astronomy, Western University, London, ON, Canada |
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Keywords: Heart, Cardiovascular Different motion correction methods for cardiac imaging were compared with no motion correction and free-motion images on a hybrid PET/MRI platform. These data were acquired in eight large animals five days after induction of myocardial infarction. PET/MRI images were acquired under different conditions of cardiac and respiratory motion: BodyCompass™, XD-GRASP, ECG gated. Upon completion of in vivo imaging, the animal was immediately euthanized within the scanner, and motion-free images were acquired. Initial quantitative evaluation of the cardiac images showed variation in mean and standard deviation values between the region of interest and different motion correction methods. |
| 4972 | Computer 26
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SENSE factor optimization for 2D RF based Reduced Field of View DWI on Cardiac at 3.0T |
| Yang Wu1, Peng Sun2, Zhigang Wu2, Xiaoxiao Zhang2, Jing Zhang2, and Jiazheng Wang2 | ||
1Department of Medical Imaging, Wuhan Asia General Hosipital, Wuhan, China, 2Philips Healthcare, Beijing, China |
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Keywords: Myocardium, Cardiovascular Diffusion MRI delivers unique information about the heart without the use of external contrast agents, Because of B0 inhomogeneity within the thorax and short transverse relaxation durations, which cause substantial distortion and signal loss, it has proven technically problematic. DWI with Zoom imaging with 2D RF pulse (iZoom) could significantly minimize distortion, but it is still vulnerable to field inhomogeneity when it is big. iZoom with SENSE could reduce distortion and signal loss even further. An in vivo research on volunteers with various SENSE factors revealed that combining iZoom with SENSE considerably improves visual quality. |
| 4973 | Computer 27
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Deep-learning-based Group-wise Motion Correction for Myocardial T1 Mapping |
| Eyal Hanania1, Lilach Barkat1, Israel Cohen1, Haim Azhari1, and Moti Freiman1 | ||
1The Technion – Israel Institute of Technology, Haifa, Israel |
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Keywords: Myocardium, Quantitative Imaging, Cardiac, Relaxation Diffuse myocardial diseases can be diagnosed using T1 mapping technique. The T1 relaxation parameter is computed through the pixel-wise model fitting. Hence, pixel misalignment resulted by cardiac motion leads to an inaccurate T1 mapping. Therefore, registration is needed. However, standard registration methods are computationally expensive. To overcome this challenge, we propose a new deep-learning-based group-wise registration approach that register all the different time points simultaneously. Our approach achieved the best median model-fitting R2 compared to baseline methods (0.9846, vs. 0.9651/0.9744/0.9756), and achieve reasonably close T1 value to the expected myocardial T1 value |
| 4974 | Computer 28
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Improving cardiac cine MRI using a deep learning-based ESPIRiT reconstruction with self attention |
| Terrence Jao1, Christopher Sandino2, and Shreyas Vasanawala1 | ||
1Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Electrical Engineering, Stanford University, Stanford, CA, United States |
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Keywords: Heart, Machine Learning/Artificial Intelligence, Deep Learning, Unrolled, Self Attention, CINE A deep learning based ESPIRiT (DL-ESPIRiT) was recently proposed to reconstruct dynamic MRI data with higher reconstruction accuracy. However, the method still has difficulty resolving fine anatomic structures. We propose incorporating self-attention to the network using a computationally lightweight squeeze-excitation block (DL-ESPIRiT SE), which uses global information to select more important features while suppressing less important ones. We demonstrate improved reconstruction with DL-ESPIRiT SE, which is most pronounced during faster cardiac motion such as in ventricular ejection. |
| 4975 | Computer 29
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2D U-Net based myocardium segmentation for quantitative sequences with limited data: demon co-registration approach |
| Habib Rebbah1 and Timothé Boutelier1 | ||
1Research & Innovation, Olea Medical, La Ciotat, France |
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Keywords: Myocardium, Segmentation Obtaining databases with expert’ manual segmentations to train U-Net is an essential but also a time-consuming operation. We explore here the effect of expanding such a database to other cases with a demon co-registration algorithm. The purpose is to speed up the manual steps but also to allow the development of segmentation algorithms for new cases. We illustrate our approach with MOLLI’ masks expanded to T2 and perfusion data. |
| 4976 | Computer 30
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Automatic catheter tracking during cardiac MRI guided cardiac catheterization using deep learning |
| Alexander Paul Neofytou1, Grzegorz Tomasz Kowalik1, Radhouene Neji1,2, Reza Razavi1, Kuberan Pushparajah1, and Sébastien Roujol1 | ||
1School of Biomedical Engineering and Imaging Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom |
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Keywords: Heart, MR-Guided Interventions A deep neural network trained on images with artificially generated catheter signal was developed and enables accurate detection of catheter signal under real-time conditions. Further investigations, with in-line integration, are now warranted to determine the benefit of this technique for improved catheter navigation. |
| 4977 | Computer 31
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Correcting motion-induced B0 shim failure at 3T CMR using a deep-learning-enabled 3D motion-resolved B0 shimming |
| Xinqi Li1, Yuheng Huang2, Xingmin Guan2, Xinheng Zhang2, Ghazal Yoosefian2, Xiaoming Bi3, Fei Han3, HsuLei Lee1, Anthony Christodoulou1, Debiao Li1, Rohan Dharmakumar2, Hui Han1, and Hsin-Jung Yang1 | ||
1Biomedical Image Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Krannert Cardiovascular Research Center, Indiana University School of Medicine, Indianapolis, IN, United States, 3Siemens Healthineers, Malvern, PA, United States |
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Keywords: Myocardium, Shims B0 inhomogeneity is a long-lasting issue for CMR in high-field (3T and above) scanners. B0 shimming is a standard way to improve the B0 field. However, motion-induced field inhomogeneity is an unknown factor in routine practice and compromises cardiac B0 shimming quality. Here, we proposed a motion-resolved cardiac B0 shimming strategy by acquiring motion-resolved cardiac B0 field maps and adopting a modified U-net model for precise and automatic shim field derivation. We showed that dynamic shimming could improve field homogeneity through the respiratory cycle and provide a reliable B0 field for free-breathing CMR at 3T. |
| 4978 | Computer 32
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Detection and tracking enhancement using 4-channels local standalone resonators for catheterized interventional MRI at 3T |
| Komlan Payne1, Yunkun Zhao1, Leslie L. Ying1, and Xiaoliang Zhang1 | ||
1Department of Biomedical Engineering, University at Buffalo, Buffalo, NY, United States |
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Keywords: Vessel Wall, Interventional Devices, Blood vessels Catheter-based RF coils are preferred over conventional external coils due to the weak detection signal from intermediate field region. One of the major issues using catheter RF coils is the design payload (feeding network, preamplifier, balun) associated with the limited space of the catheter. The technique also lacks efficient way to track the catheter during the procedure. To overcome these challenges, we propose 4-channel standalone and wireless resonators to amplify the local B1 field while a body coil is used as the transceiver. The receive B1 fields with and without the local resonators are obtained for field enhancement analysis. |
| 4979 | Computer 33
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Patient specific respiratory motion correction for cardiac MRI |
| Jiameng Diao1, Yang Liu1, Wenjian Liu1, Yiming Tao1, Jianing Geng1, Shang Cao1, Jiayu Zhu2, Junpu Hu2, Jian Xu3, Zijian Zhou1, Haikun Qi1,4, and Peng Hu1,4 | ||
1School of Biomedical Engineering, ShanghaiTech University, Shanghai, China, 2United Imaging Healthcare, Shanghai, China, 3UIH America, Inc., Houston, TX, United States, 4Shanghai Clinical Research and Trial Center, Shanghai, China |
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Keywords: Heart, Motion Correction Magnetic resonance imaging (MRI) is susceptible to respiratory motion-induced artifacts due to the relatively slow data acquisition. These artifacts remain an impediment to clinical application and are further amplified in cardiovascular MRI. Respiratory motion model is an effectively method to reduce motion artifacts. In this study, we proposed a novel patient-specific respiratory motion correction method with more reliable training data and capability to perform spoke-wise correction. Combined with compressed sensing, parallel imaging, image registration and model fitting, this method greatly reduces respiratory motion artifacts. |
| 4980 | Computer 34
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Spherical harmonic shim analysis of B0 distributions in cardiac imaging planes from 921 subjects |
| Yun Shang1, Sebastian Theilenberg1, Boyu Peng2, Michael Hock3, Laura M. Schreiber3,4, Sachin Jambawalikar1,2, and Christoph Juchem1,2 | ||
1Department of Biomedical Engineering, Columbia University in the City of New York, New York, NY, United States, 2Department of Radiology, Columbia University in the City of New York, New York, NY, United States, 3Chair of Molecular and Cellular Imaging, Comprehensive Heart Failure Center (CHFC), Würzburg, Germany, 4Section of Medical Physics, Department of Radiology, Mainz University Hospital, Mainz, Germany |
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Keywords: Heart, Shims Cardiac functional scans adopting bSSFP sequences suffer from dark band artifacts due to B0 inhomogeneity. The best remedy to mitigate this issue is through cardiac B0 shimming. A limited understanding of the B0 conditions in clinical diagnostic orientations impedes the development of an optimal B0 shim strategy in the human heart. Here we perform a theoretical analysis of spherical harmonic B0 shim at 3 T using a static global approach and slice-specific dynamic shim updating in the short-axis views of human hearts from 921 subjects as a starting point for the development of optimized cardiac B0 shim strategies. |
| 4981 | Computer 35
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Accelerated, Free-Breathing 3D Cardiac T1ρ Mapping Pulse Sequence with XD-GRASP Reconstruction |
| Suvai Gunasekaran1, KyungPyo Hong1, Roberta Catania1, Joshua Robinson2, Rod Passman3, Aggelos Katsaggelos4, Cynthia Rigsby5, Walter Witschey6, and Daniel Kim1 | ||
1Radiology, Northwestern University, Feinberg School of Medicine, Chicago, IL, United States, 2Cardiology, Lurie Children’s Hospital, Chicago, IL, United States, 3Cardiology, Northwestern University, Feinberg School of Medicine, Chicago, IL, United States, 4Electrical and Computer Engineering, Northwestern University, Evanston, IL, United States, 5Radiology, Lurie Children’s Hospital, Chicago, IL, United States, 6Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States |
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Keywords: Myocardium, Quantitative Imaging, Fibrosis T1ρ mapping is an emerging non-contrast pulse sequence for measuring cardiac fibrosis. Unfortunately, current T1ρ techniques suffer from lack of coverage, poor spatial resolution, and long scan time. Thus, we developed an accelerated, free-breathing 3D cardiac T1ρ mapping pulse sequence using XD-GRASP reconstruction including both respiratory and contrast dimensions; additionally, view sharing and KWIC filtering were incorporated to improve spatial resolution. This sequence was tested in 8 patients undergoing clinically indicated cardiac MRI, resulting in robust image quality and T1ρ values that are in agreement with literature. |
| 4982 | Computer 36
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Dual-Band Adiabatic Pulses in cardiac MRI: Application in Black Blood Imaging at 3T |
| Ayda Arami1, Christal van de Steeg-Henzen2, Hildo J.Lamb3, and Sebastian Weingärtner1 | ||
1TU Delft, Delft, Netherlands, 2HollandPTC, Delft, Netherlands, 3LUMC, Leiden, Netherlands |
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Keywords: Myocardium, RF Pulse Design & Fields Black-Blood imaging is an integral part of clinical cardiac MRI, due to it’s clear depiction of the cardiac morphology. Double inversion recovery, is most commonly used for black-blood contrast, by successively applying a non-selective inversion and a slice-selective reinversion. In this work, we investigate dual band adiabatic inversion pulses, as an alternative, to achieve nulling of the blood signal outside of the imaging slice. Thorough blood suppression and comparable noise performance to double inversion recovery were demonstrated in vivo while achieving an 11% reduction in SAR and a 10% reduction in pulse duration. |
| 4983 | Computer 37
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Ultrahigh Field CMR for the Assessment of Cardiac Function – Scan Rescan Reproducibility and Shim Limitations |
| David Lohr1, Wiebke Schlötelburg2, Maxim Terekhov1, and Laura Maria Schreiber1 | ||
1Chair of Molecular and Cellular Imaging, Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany, 2Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany |
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Keywords: Myocardium, High-Field MRI In this study we aim to analyze blood tissue contrast (BTC), SNR, and reproducibility in measurements of cardiac function at 7T. Furthermore, we assess shim quality and its impact on image quality as well as T2*. Measurements are performed in n=7 healthy volunteers using a 7T system. Diastolic BTC and SNR in scan1 and scan2 were 2.14±0.24 and 2.22±0.33 as well as 96±35 and 105±29, respectively. Reproducibility assessed via intra class correlation coefficient was found to be excellent for ejection fraction (0.93), myocardial mass (0.99), stroke volume (0.91), end-systolic volume (0.94), and end-diastolic volume (0.93). |
| 4984 | Computer 38
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Off-resonance encoded fat suppression methods for 5D whole-heart free-running cardiac MRI at 1.5T |
| Yasaman Safarkhanlo1,2, Jerome Yerly3,4, Mariana Falcao3, Adèle LC Mackowiak2,3,5, Davide Piccini3,6, Matthias Stuber3,4, Bernd Jung2,5, Christoph Gräni1,2, and Jessica AM Bastiaansen2,5 | ||
1Department of Cardiology, University Hospital Bern, Inselspital, Bern, Switzerland, 2Translation Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland, 3Department of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, 4Center for Biomedical Imaging, Lausanne, Switzerland, 5Diagnostic, Interventional and Pediatric Radiology (DIPR), University Hospital Bern, Inselspital, Bern, Switzerland, 6Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland |
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Keywords: Heart, Fat, data acquisition, data analysis, image reconstruction, low-field MRI The presence of fat signals around the heart can affect the diagnostic quality of cardiovascular MR images. There are multiple fat-suppression pulses, such as FISS, and off-resonance water-excitation (WE) pulses, such as BORR, LIBRE, and LIBOR, that have been developed for the free-running balanced Steady-State Free-Precession (bSSFP) sequences at low-field MRI (1.5T). These fat-suppression pulses have never been thoroughly compared to each other, therefore, in this work, we implemented four different fat-suppression pulses and validated their performance on phantoms and healthy volunteers. Our results indicated LIBOR provided better fat suppression compared to BORR and LIBRE, while having fast acquisition time. |
| 4985 | Computer 39
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Recovering image orientation for unconventional acquisition plane with deep learning algorithm: cardiac magnetic resonance case. |
| Habib Rebbah1 and Timothé Boutelier1 | ||
1Research & Innovation, Olea Medical, La Ciotat, France |
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Keywords: Myocardium, Segmentation Deducing the orientation main view of an image from the DICOM information could be complicated especially for unconventional image plane as for cardiac MR. We explore here the feasibility of deducing the orientation of the image based on CNN approach. |
| 4986 | Computer 40
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A clinical application of deep learning reconstructed myocardial late gadolinium enhancement on short-breath-hold patients |
| Xuefang Lu1, Weiyin Vivian Liu2, Yuchen Yan1, Changsheng Liu1, Wei Gong1, Yan Wang1, Yilin Zhao1, Guangnan Quan3, and Yunfei Zha1 | ||
1Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, China, 2GE Healthcare, MR Research China, Beijing, China, 3General Electric Medical (China) Co, Beijing, China |
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Keywords: Myocardium, Image Reconstruction SNR and CNR are essential for radiologists to precisely assess the signal enhancement in myocardia tissues. High-resolution late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) is important but often possess low SNR and takes long scan time. Compared with original PSMDE (PSMDEO), AIRTM Recon DL-based PSMDE (PSMDEDL) effectively and significantly improved SNR, CNR and image quality without extra scan time. High-resolution PSMDEDL images also accelerated diagnossis speed of identifying defected tissues from noisy but normal myocardial tissues and elevated the diagnosis confidence despite no statistically different diagnostic performance between PSMDEDL and PSMDEO images. |
| 5123 | Computer 21
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Data-driven clustering for ECG-free cine MRI with robustness against irregular cardiac motion |
| Zhengyang Ming1,2, Arutyun Pogosyan3, Anthony G. Christodoulou4,5, J. Paul Finn1,2, Dan Ruan1,4,6, and Kim-Lien Nguyen1,2,3,4 | ||
1Physics and Biology in Medicine Graduate Program, University of California,Los Angeles, Los Angeles, CA, United States, 2Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 3Division of Cardiology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States, 4Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 5Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 6Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States |
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Keywords: Arrhythmia, Machine Learning/Artificial Intelligence Both ECG-gating and self-gated approaches are used for cardiac motion binning in segmented cardiac cine MRI. Typical self-gated methods reduce ECG-dependency by assuming periodic cardiac motion, but may be less reliable in the presence of irregular cardiac motion. We propose a novel clustering algorithm that incorporates regularization in both temporal and cluster dimension to provide robustness against irregular cardiac motion in complex arrhythmias such as atrial fibrillation and premature ventricular contraction. Compared with images from k-means clustering, initial validation using the modified algorithm shows higher image quality scores with comparable single-to-noise ratio (SNR) and image sharpness. |
| 5124 | Computer 22
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A Data Augmentation Framework to Improve R-peak Detection in ECG Recorded in MRI Scanners |
| Maroua Mehri1,2, Pierre Aublin3, Guillaume Calmon1, Freddy Odille1,3,4, and Julien Oster3,4 | ||
1Epsidy, Nancy, France, 2University of Sousse, National School of Engineers, LATIS-Laboratory of Advanced Technology and Intelligent Systems, Sousse, Tunisia, 3IADI, INSERM U1254 and Université de Lorraine, Nancy, France, 4CIC-IT 1433, INSERM, Université de Lorraine and CHRU Nancy, Nancy, France |
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Keywords: Heart, Data Analysis, Machine learning/Artificial intelligence Detecting R-peaks in ECG using deep learning (DL) requires large, annotated datasets. Such datasets with the MRI-specific magneto-hydrodynamic (MHD) effect, do not exist currently. We propose a robust data augmentation framework using records available online, adding realistic MHD artifacts to augment the training dataset. MHD artifacts were modelled from eight 3T MRI-ECG records, and added to 75 non-MRI-ECG records. The R-peak detection was evaluated on six 3T MRI-ECG records. Compared to a DL model trained without data augmentation, the number of false positives and missed detections were reduced by 57.6% and 16.4%, the overall error was decreased by 25%. |
| 5125 | Computer 23
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CNNT denoising for cine imaging at 0.55T with higher acceleration rates |
| Hui Xue1, Ahsan Javed1, Rajiv Ramasawmy1, Azaan Rehman1, Peter Kellman1, and Adrienne E Campbell-Washburn1 | ||
1National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States |
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Keywords: Heart, Machine Learning/Artificial Intelligence Low field MRI systems are promising to increase the accessibility of cardiac MRI, at the expense of lower SNR. Here, we present the application of a g-factor-savvy denoising for cine imaging at 0.55T to increase useable acceleration rate. We used a model that combines convolutional neural networks and transformer model. The denoising network uses complex 2D+time images in SNR-units and g-factor maps as inputs and was trained with 3T data. The percent mean myocardial SNR gain at 0.55T across 9 healthy volunteers was 97±31% (R=2) and 122±22% (R=3), with no indication of overt temporal or spatial smoothing. |
| 5126 | Computer 24
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Deep Learning Pipeline for Preprocessing and Segmenting Cardiac Magnetic Resonance of Single Ventricle Patients from an Image Registry |
| Tina Yao1,2, Nicole St. Clair3, John Gold3, Gabriel Miller3, David Schidlow3, Sunil Ghelani3, Rahul Rathod3, Jennifer Steeden1, and Vivek Muthurangu1 | ||
1Institute of Cardiovascular Science, University College London, London, United Kingdom, 2Institute of Health Informatics, University College London, London, United Kingdom, 3Department of Cardiology, Boston Children's Hospital, Boston, MA, United States |
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Keywords: Heart, Machine Learning/Artificial Intelligence We have created an end-to-end machine learning pipeline that takes cardiac magnetic resonance scans straight from a registry of single ventricle patients, performs image classification, calculates bounding boxes, and segments the ventricles. The clinical utility of the pipeline is that there is very little human preprocessing required from the clinicians. The pipeline has great robustness as it is trained on multicenter data from different countries, with different scanners, image sizes and aspect ratios, patient ages (relating to heart sizes), and the inherent variability of single ventricle patients. Heart metrics calculated from our pipeline can guide treatment for single ventricle patients. |
| 5127 | Computer 25
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Improved T1, T2 and PDFF mapping with rosette MRF using virtual-coil + low-rank + patch-based regularization |
| Gastao Cruz1, Yuchi Liu1, Evan Cummings1, Jesse Hamilton1, Vikas Gulani1, and Nicole Seiberlich1 | ||
1Department of Radiology, University of Michigan, Ann Arbor, MI, United States |
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Keywords: Heart, MR Fingerprinting In this work, T1/T2/PDFF mapping with rosette cardiac MRF is improved by exploiting the idea of virtual coils along with subspace constrained reconstruction. The Hermitian symmetry of k-space is explicitly included in the forward model via virtual coils and combined with global low-rank models. This model is further combined with a regularizer leveraging prior information from dictionaries, patch-similarity, and locally low-rank. This virtual-coil + low-rank + patch-based approach is used to jointly reconstruct multi-echo rosette MRF data for improved quality of the final T1, T2, and PDFF maps. |
| 5128 | Computer 26
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Cardiac Magnetic Resonance Feature Tracking for Detection of Acute Cardiac Allograft Rejection after Heart Transplantation |
| Yunling Li1, Kai Yang2, Xiuyu Chen2, Jianxiu Lian3, Yong Sun1, and Shihua Zhao2 | ||
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China, HarBin, China, 2Department of Magnetic Resonance Imaging, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Beijing, China, 3Beihang University, Beijing, China |
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Keywords: Heart, Cardiovascular, Acute Cardiac Allograft Rejection Acute cardiac allograft rejection is a major cause of morbidity and mortality after heart transplantation. Reliable non-invasive diagnostic techniques for acute cardiac allograft rejection (ACAR) are unavailable. Cardiac magnetic resonance feature tracking can detect global functional changes in the longitudinal, radial, and circumferential directions during the early stages of graft rejection. We found that cardiac magnetic resonance feature tracking (CMR-FT)-derived global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) are safe, noninvasive, and gadolinium contrast-free parameters for ACAR diagnosis. CMR-FT may provide a method that can reduce the dependency on invasive EMBs after heart transplantation. |
| 5129 | Computer 27
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Deep-learning-based super-resolution technique for cine cardiac magnetic resonance |
| Satonori Tsuneta1, Satoru Aono2, Rina Kimura1, Jihun Kwon3, Takuya Aoike2, Masami Yoneyama3, Kinya Ishizaka2, Noriyuki Fujima1, and Kohsuke Kudo4 | ||
1Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan, 2Department of Radiological Technology, Hokkaido University Hospital, Sapporo, Japan, 3Philips Japan, Ltd., Tokyo, Japan, 4Department of Diagnostic Imaging, Hokkaido University Graduate School of Medicine; Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sapporo, Japan |
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Keywords: Myocardium, Data Processing Cine cardiac magnetic resonance (CMR) imaging is an optimal cardiac volumetric analysis method because of its high contrast resolution. However, its spatial resolution is limited owing to prolonged scanning and breath-holding. Although compressed sensing–sensitivity encoding (Compressed SENSE; CS) and its deep-learning-based advancement (SmartSpeed AI; SSAI) can reduce the scan time, the spatial resolutions remain unchanged. Herein, we investigated the effect of a deep-learning-based super-resolution technique (SmartSpeed Precise Image; SSPI) on the cine CMR visual image quality in comparison with CS and SSAI with conventional zero-filling interpolation; resultantly, the SSPI significantly improved the visual image quality scores. |
| 5130 | Computer 28
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Detection of Congenital Heart Disease in MR images using Machine Learning |
| Dominik Daniel Gabbert1, Lennart Petersen1,2, Abigail Burleigh1, Simona Boroni Grazioli1, Sylvia Krupickova3, Reinhard Koch2, Anselm Sebastian Uebing1, Monty Santarossa2, and Inga Voges1 | ||
1Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital Schleswig-Holstein, DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Kiel, Germany, 2Multimedia Information Processing Group, Kiel University, Kiel, Germany, 3Departments of CMR and Paediatric Cardiology, Royal Brompton Hospital, London, United Kingdom |
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Keywords: Heart, Machine Learning/Artificial Intelligence, Congenital Heart Disease We present a new method for detection of hypoplastic left heart syndrome (HLHS) based on the spatial arrangement of 7 distinctive anatomical landmarks in CMR images. The method was applied to the axial SSFP CMR scans of 46 patients with HLHS and 33 healthy controls. A tailor-made U-net-like deep convolutional network (CNN) with a shared 3D-convolutional encoder backbone and 7 segmentation heads was used for prediction of landmarks. Classification based exclusively on the coordinates of the detected landmarks had an accuracy of 98.7%. In future studies, the method may be applied to HLHS subgroups or other cardiac diseases. |
| 5131 | Computer 29
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Novel Reconstruction Method to Improve the Sharpness of Free Breathing Cardiac MR Late Gadolinium Enhancement Images on a Commercial 0.55T System |
| Yu Ding1, Yingmin Liu1, Chong Chen1, Ning Jin2, Rizwan Ahmad1, and Orlando Simonetti1 | ||
1The Ohio State University, Columbus, OH, United States, 2Siemens Healthineers, Columbus, OH, United States |
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Keywords: Myocardium, Low-Field MRI, Late Gadolinium Enhancement Low-field cardiac MR imaging has intrinsically low SNR that degrades the image quality, especially for LGE imaging. Using multiple acquisitions and motion-corrected averaging is a well-established method to improve SNR. However, the ineffectiveness of MOCO at low field leads to blurring. We proposed a novel method that integrates motion correction into compressed sensing and reconstructs a single motion-corrected image. Quantitative sharpness measurements demonstrate that the proposed method improves boundary sharpness, independent of differences in SNR. |
| 5132 | Computer 30
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Deep Learning-Based Reconstruction of Accelerated Cardiac Cine MRI at 0.55T |
| Marc Vornehm1,2, Jens Wetzl2, Daniel Giese2,3, Jianing Pang4, Rizwan Ahmad5, and Florian Knoll1 | ||
1Computational Imaging Lab, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 2Magnetic Resonance, Siemens Healthcare GmbH, Erlangen, Germany, 3Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 4Siemens Medical Solutions USA Inc., Chicago, IL, United States, 5Biomedical Engineering, The Ohio State University, Columbus, OH, United States |
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Keywords: Heart, Low-Field MRI Acceleration of cardiac cine MRI is highly desirable in order to decrease the required breath-hold duration. On low-field MRI systems in particular, this could help make cardiac MRI more widely available. We present a method based on the Variational Network for reconstruction of cardiac cine MRI, trained on data from 1.5 and 3T systems. Reconstructions of retrospectively and prospectively undersampled acquisitions at 0.55T with an acceleration rate of eight are shown and compared to Compressed Sensing reconstructions. Despite the domain shift to low-field data, the neural network achieved an SSIM of 94.6%, which is comparable to the Compressed Sensing results. |
| 5133 | Computer 31
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“ShortCardiac” - an open-source tool for assessing cardiac function quickly |
| Karl Ludger Radke1, Janina Hußmann1,2, Lena Röwer1,2, Dirk Voit3, Jens Frahm3, Gerald Antoch1, Dirk Klee1, Frank Pillekamp1,2, and Hans-Jörg Wittsack1 | ||
1University Düsseldorf, Department of Diagnostic and Interventional Radiology, Düsseldorf, Germany, 2Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children's Hospital Düsseldorf, D-40225 Düsseldorf, Germany, Düsseldorf, Germany, 3Biomedical NMR, Max Planck Institute for Multidisciplinary Sciences, D-37070 Göttingen, Germany, Göttingen, Germany |
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Keywords: Heart, Software Tools In this work, we propose a new open-source framework for cardiac functional analysis. Our proposed framework can be used in a pipeline with the commercial software Circle cvi42 as well as the free software ITKSnap and enables a step towards a fully automated, reproducible, and quantitative assessment of MR images in clinical routine. |
| 5134 | Computer 32
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DeepCardioPlanner: Deep Learning-based tool for automatic CMR planning |
| Pedro Louro Costa Osório1, Markus Henningsson2,3,4, Alberto Gomez Herrero5,6, Rita G. Nunes1, and Teresa M. Correia6,7 | ||
1Institute for Systems and Robotics - Lisboa and Department of Bioengineering, Instituto Superior Técnico - Universidade de Lisboa, Lisbon, Portugal, 2Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, 3Centre for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 4MR Physics, Perspectum Ltd, Oxford, United Kingdom, 5Ultromics Ltd, Oxford, United Kingdom, 6School of Biomedical Engineering Imaging Sciences, King’s College London, London, United Kingdom, 7Centre for Marine Sciences - CCMAR, Faro, Portugal |
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Keywords: Heart, Machine Learning/Artificial Intelligence, View Planning Cardiac Magnetic Resonance (CMR) is a powerful technique which can be used to perform a comprehensive cardiac examination. However, its adoption is often limited to specialised centres, in part due to the need for highly trained operators to perform the complex procedures of determining the 4 standard cardiac planes: 2-, 3-, 4-chamber and short axis views. To automate view planning, a deep learning-based tool (DeepCardioPlanner) has been proposed to regress the view defining vectors from a rapidly acquired 3D image. It successfully takes advantage of multi-objective learning to allow accurate, fast and reproducible view prescriptions without any operator input. |
| 5135 | Computer 33
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Assessment of cardiac function using free-breathing, motion corrected artificial intelligence cine: comparison with conventional cine |
| Lingping Ran1, Lu Huang1, Xianghu Yan1, Yun Zhao1, and Liming Xia1 | ||
1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China |
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Keywords: Heart, Heart Routine cardiac functional assessment with conventional balanced steady state free precession (bSSFP) cine sequence generally requires multiple breath-holding (BH) and long examination time. The purpose of this study was to evaluate the image quality and bi-ventricular functional analysis using a novel free-breathing (FB) artificial intelligence (AI) cine method with motion corrected (MOCO) in a clinical context. Compared to conventional multiple BHs cine, the proposed FB-MOCO AI cine method achieved comparable image quality with shortened scan times. No significant difference in ventricular volumetric and functional parameters were found, suggesting its potential applicability for clinical applications. |
| 5136 | Computer 34
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2D U-Net for left heart segmentation for CINE sequences, deal with new target data: comparison of 3 approaches |
| Habib Rebbah1, Guillaume Gautier1, and Timothé Boutelier1 | ||
1Research & Innovation, Olea Medical, La Ciotat, France |
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Keywords: Heart, Segmentation In the case of U-Net based segmentation algorithms, we propose to explore a common question of the medical image research teams: using already existing algorithm or train a new one specific to the target data. We compared for the cardiac CINE case three approaches: using an algorithm trained with external data, train a new one with the taget data from scratch, and fin-tune the first one with the target data. |
| 5137 | Computer 35
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Unsupervised deep learning with variational autoencoder for image quality improvement in ultrafast cardiac cine MRI: Initial results |
| Yajing Zhang1, Guohui Ruan1, Tianyu Han2, Christiane Kuhl3, Masami Yoneyama4, Daniel Truhn3, and Shuo Zhang3,5 | ||
1MR Clinical Science, Philips Health Technology, Suzhou, China, 2RWTH University Aachen, Aachen, Germany, 3Diagnostic and Interventional Radiology, University Hospital RWTH Aachen, Aachen, Germany, 4Philips Japan, Tokyo, Japan, 5Philips Market DACH, Hamburg, Germany |
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Keywords: Myocardium, Cardiovascular Ultrafast imaging with high acceleration in cardiac MRI is of great clinical interest, but so far often results in inferior image quality that prevents its use in routine diagnosis. In this work, we aim to establish an unsupervised deep learning neural network based on vector quantized variational autoencoder for noise reduction and image quality improvement. Initial results on both public and clinical data promise a new approach to the existing methods. Further investigations with focus on its effectiveness of performance in real world applications are warranted. |
| 5138 | Computer 36
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Cine MRI reconstructed from 3T contrast-enhanced free-running 5D coronary MRA: comparison to standard 2D cine MRI |
| Haruno Ito1, Masaki Ishida1, Masafumi Takafuji1, Shinichi Takase1, Yoshiaki Komori2, Davide Piccini3,4, Jessica A.M. Bastiaansen4, Jérôme Yerly4,5, Matthias Stuber4,5, and Hajime Sakuma1 | ||
1Radiology, Mie University Hospital, Tsu, Mie, Japan, 2Siemens Healthcare K.K., Tokyo, Japan, 3Advanced clinical imaging technology, Siemens Healthineers International AG, Lausanne, Switzerland, 4Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 5CIBM Center for Biomedical Imaging, Lausanne, Switzerland |
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Keywords: Heart, Heart, Cine MRI Cine MRI derived from 3T contrast-enhanced free-running 5D whole-heart coronary MRA (free-running cine MRI) was compared with standard 2D cine MRI in 30 patients with suspected CAD. In a selected patient, temporal width was optimized to 50 ms. Then, in the remaining 29 patients, free-running cine MRI provided good agreement in LV volume and function quantification with standard 2D cine MRI with a good inter-observer reproducibility. The results suggest that free-running cine MRI allows for a shorter scan protocol by skipping the standard 2D cine MRI. |
| 5139 | Computer 37
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Evaluation of image quality and global cardiac function for deep learning accelerated cardiac Cine |
| Xucheng Zhu1, Suryanarayanan Kaushik2, Frandics Chan3, Melany Atkins4, Prashant Nagpal 5, Reed Busse2, and Martin Janich6 | ||
1GE Healthcare, Menlo Park, CA, United States, 2GE Healthcare, Waukesha, WI, United States, 3Radiology, Stanford University, Palo Alto, CA, United States, 4Radiological Consultants, Inova Fairfax Hospital, Fairfax, VA, United States, 5Radiology, University of Wisconsin–Madison, Madison, WI, United States, 6GE Healthcare, Munich, Germany |
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Keywords: Heart, Image Reconstruction, Deep learning, reconstruction Cardiac bSSFP Cine is widely used clinically; however, it is time consuming and requires multiple breath-holds. Deep learning-based accelerated Cine (DLCine) is a novel technique combining accelerated variable density sampling and deep learning regularized reconstruction that allows much higher acceleration compared to conventional Cine with parallel imaging. The purpose of this work was to compare image quality and global cardiac function utilizing DLCine versus conventional Cine by three expert readers. The results demonstrate that DLCine can be used to reduce the scan time while maintaining image quality and providing accurate global cardiac function measurement. |
| 5140 | Computer 38
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Blind Source Separation Improves the Precision and Robustness of Self-Gated Motion Extraction in Free-Running 4D Whole-Heart MRI |
| Isabel Montón Quesada1, Augustin C. Ogier1, Jérôme Yerly1,2, Jonas Richiardi1, Christopher W. Roy1, Juerg Schwitter3, Matthias Stuber1,2, and Ruud B. van Heeswijk1 | ||
1Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 2CIBM Center for BioMedical Imaging, Lausanne, Switzerland, 3Cardiology Service, Cardiovascular Department, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland |
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Keywords: Heart, Image Reconstruction Several cardiac and respiratory motion-resolved free-running acquisition techniques have recently been developed, but automated self-gated motion extraction with principal component analysis (PCA) alone remains challenging and sometimes fails to correctly identify the components related to cardiac motion. We combined three blind source separation algorithms (fastICA, ICASSO and SOBI) with PCA and compared them with gold-standard ECG R-wave triggers in 10 healthy volunteers to determine the most precise and robust self-gated cardiac trigger extraction. Of these tested techniques, PCA combined with SOBI resulted in the lowest variability of the cardiac intervals relative to ECG intervals (p=0.03) and the sharpest images (p=0.03). |
| 5141 | Computer 39
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A feasibility study of deep learning cardiac cine comparing image quality and volumetry with the conventional ASSET cine |
| Shigeo Okuda1, Ryo Tsukada2, Manabu Arai1, Sari Motomatsu2, Atsushi Nozaki3, Xucheng Zhu4, and Masahiro Jinzaki1 | ||
1Radiology, Keio University School of Medicine, Tokyo, Japan, 2Keio University Hospital, Tokyo, Japan, 3GE Healthcare Japan, Tokyo, Japan, 4GE Healthcare, Menlo Park, CA, United States |
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Keywords: Heart, Cardiovascular, Accelerated cine Accelerated cardiac cine was obtained with deep learning reconstructed technique on ten patients (DL Cine). Three series of DL Cine with different parameters were acquired, including reduction factor (RF) of 12 under free breathing (FB), RF of 12 during one breathhold (R12) and RF = 9 dividing the left ventricular short axis into two slabs during each breathhold (R9). The two readers evaluate image quality (IQ) score and measure the cardiac functional parameters and compared them with the conventional ASSET cine. Although the IQ score was smaller than ones of the conventional cine, they are clinically acceptable. We found good correlations between volumetry on the conventional and DL cine. |
| 5142 | Computer 40
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Reconstruction of Dynamic MRI Tensor Data Using Frequency Low-rank and Sparsity Prior |
| Runyu Yang1, Haozhong Sun1, and Huijun Chen1 | ||
1Center for Biomedical Imaging Research, Tsinghua University, Beijing, China |
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Keywords: Heart, Image Reconstruction Obtaining high spatial and temporal resolution image in dynamic magnetic resonance imaging is a huge challenge. It is effective to use low-rank and sparse prior jointly for dMRI reconstruction. However, the models represented the tensor data into a matrix, which can not completely explore the spatiotemporal correlation information. Besides, using nuclear norm as convex surrogate of the rank function to enforce the low-rank, which may lead to the sub-optimal result. Hence, we proposed the piecewise frequency tensor nuclear norm in the low-rank and joint sparse prior to reconstructed data. The proposed method was tested in cardiac cine and perfusion data. |