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| 2254 | Computer 81
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Attention-based Two Stage Deep Learning Model for the Segmentation and Classification of Pelvic and Sacral Tumors on Routine MRI |
| Ping Yin1 and Nan Hong1 | ||
1Department of Radiology, Peking University People's Hospital, Beijing, China |
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Keywords: MSK, Tumor Early detection and correct diagnosis are key to adequate and successful treatment of PSTs. Based on multi-sequence MRI images, physician’s labeling, segmentation model, and clinical features, six classification models were built. The highest scoring model (model 6) achieved 0.836 AUC, 0.781 ACC in the prospective test set, which was comparable to that of senior residents and junior resident. However, the diagnosing time of DL model is significantly shorter than physicians. Our attention-based two stage DL model allowed the accurate segmentation and classification of benign and malignant PSTs without enhanced MRI and may thus facilitate diagnosis. |
| 2255 | Computer 82
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MR-Guided Cryoablation to Upregulate the Immune Response in Osteosarcoma |
| Dara L Kraitchman1,2,3, Michele Doucet4, Sarah J Powers3, Alainah Bhutta5, Emily Kulp6, Tina Ehtiati7, Cheri Rice1, Cindy Maranto1, Kathleen Gabrielson3, Cory Brayton3, and Brian Ladle4 | ||
1Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2Center for Image-Guided Animal Therapy, Baltimore, MA, United States, 3Department of Molecular & Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, United States, 4Department of Oncology, Johns Hopkins University, Baltimore, MD, United States, 5University of Georgia College of Veterinary Medicine, Athens, GA, United States, 6Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, United States, 7Siemens Medical Solutions USA, Inc., Baltimore, MD, United States |
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Keywords: Bone, MR-Guided Interventions, cryoablation Osteosarcoma (OSA) is the most common bone cancer in young adults and dogs and almost invariably lethal when the cancer spreads. MR-guided cryoablation offers the potential to cause direct bone necrosis and palliative pain management and has shown the potential to upregulate the immune response in prostate and breast cancer to prevent or shrink metastatic disease. The current study seeks to determine the immune response of MR-guided cryoablation in spontaneously occurring canine osteosarcoma in comparison to X-ray-guided intratumoral Stimulator of Interferon Gene (STING) immunotherapy as determine by survival time and measurement of inflammatory infilitrates. |
| 2256 | Computer 83
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Simplified, ‘single-step’ segmentation and quantification of bone marrow oedema using deep learning |
| Timothy JP Bray1, Alexis JP Jones2, Margaret A Hall-Craggs1, and Hui Zhang3 | ||
1Centre for Medical Imaging, University College London, London, United Kingdom, 2Rheumatology, University College London Hospital, London, United Kingdom, 3Centre for Medical Image Computing, University College London, London, United Kingdom |
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Keywords: Bone, Inflammation We present a deep learning workflow which segments and quantifies bone marrow oedema (BMO) in a single deep learning step. Detection and quantification of BMO plays a crucial role in diagnosis and monitoring of patients with inflammatory diseases of the skeleton, including spondyloarthritis (SpA), and various segmentation methods have been developed to facilitate BMO quantification. However, previous attempts have used multiple algorithms in sequence to achieve satisfactory performance. To improve on this, we propose a simplified approach that avoids the need for such sequential algorithms, thus simplifying the workflow, eliminating potential error sources and reducing the need for human input. |
| 2257 | Computer 84
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Whole-tumor histogram analysis of DWI and DCE-MRI for soft tissue sarcoma: Correlation with HIF-1alpha expression |
| Xiangwen Li1, Qing Li2, and chen shuang3 | ||
1Huashan hospital Fudan university, Shang hai, China, 2MR Collaborations, Siemens Healthcare Ltd., Shang hai, China, 3Radiology, Huashan hospital Fudan university, Shang hai, China |
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Keywords: MSK, Diffusion/other diffusion imaging techniques In this study, we initially revealed the feasibility of conventional MRI features and whole-tumor histogram features of diffusion-weighted imaging (DWI) and dynamic contrast-enhanced MRI (DCE-MRI) parameters in assessing hypoxia-inducible factor 1-alpha (HIF-1α) expression of soft tissue sarcomas (STS). On this basis, we performed a short-term survival analysis of the study population. The findings suggest that MRI morphological features and histogram features of quantitative parameters help predict higher HIF-1α expression and may significantly predict prognosis in patients with STS. |
| 2258 | Computer 85
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Sex differences in subcutaneous fat thickness and bone marrow fat area and their relationship to BMI and age |
| Talon Johnson1, Jimin Ren1,2, and Anke Henning1,2 | ||
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States |
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Keywords: Bone, Fat, Metabolism, diabetes This study evaluated the sex factor in affecting fat distribution in bone marrow and subcutaneous tissue in human lower extremity. Bone marrow fat (BMF) was characterized by the cross-sectional area in the fibula bone and subcutaneous fat (SF) was measured by the thickness of SF (SFT) in the periphery of calf muscle. It is found that SFT and BMF are statistically significantly correlated to BMI and age, respectively, in women (n = 43), but not in men (n = 59). For a subgroup of subjects with thinner SFT (<15 mm, n = 87), SFT is negatively correlated to BMF. |
| 2259 | Computer 86
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Intravoxel incoherent motion and dynamic contrast-enhanced magnetic resonance imaging for neoadjuvant chemotherapy response evaluation in patients with osteosarcoma |
| Ping Yin1 and Nan Hong1 | ||
1Department of Radiology, Peking University People's Hospital, Beijing, China |
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Keywords: MSK, Multimodal, Osteosarcoma In this study, we simultaneously compared the predictive value of ADC, IVIM and semi-quantitative and quantitative DCE-MRI parameters for the efficacy of NACT. We found that D-Bi, D*-Bi, and f-Bi post-NACT and ΔD-Bi had statistical differences between the good response group and the poor response group. ROC curve showed that f-Bi post-NACT had the best performance in all parameters, with AUC of 0.769, sensitivity of 1, and specificity of 0.538. Correlation analysis showed that the efficacy of NACT was negatively correlated with D-Bi, D*-Bi post-NACT and ΔD-Bi, and was significantly positively correlated with f-Bi post-NACT.
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| 2260 | Computer 87
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Evaluating blood supply changes in the osteonecrosis of the femoral head using gadobutrol-based steady-state MRA |
| Zhenhong Liao1 and Xiaoyong Zhang2 | ||
1Deyang People's Hospital, Sichuan, China, 2Philips Healthcare, Chengdu, China |
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Keywords: Joints, Vessels, osteonecrosis of the femoral head Dynamic evaluation of retinacular arteries is essential for understanding blood supply changes occurring in osteonecrosis of the femoral head (ONFH). The steady-state (SS) magnetic resonance angiography (MRA) may be an effective method as our previous study suggested, however its feasibility is yet to be determined. Therefore, this study intends to use gadobutrol-based SS MRA to evaluate the blood supply of ONFH. |
| 2261 | Computer 88
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Imaging perfusion in the vertebral bone marrow and subchondral bone using FAIR ASL |
| L. Tugan Muftuler1 and Matthew D. Budde1 | ||
1Medical College of Wisconsin, Milwaukee, WI, United States |
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Keywords: MSK, Perfusion, lumbar spine, low back pain Some patients with chronic low back pain (cLBP) do not show any diagnosable conditions in conventional imaging methods. Studies suggested that pain could be associated with the degeneration of vertebral endplate region in those nonspecific cLBP patients. The endplates around degenerating discs experience trauma, which leads to inflammation, angiogenesis, neurogenesis and infection. Currently, there is no established method to diagnose such pathologies. We previously reported associations between increased endplate perfusion and experience of cLBP using DCEMRI. In this study we explored Arterial Spin Labeling to avoid using contrast agents. Results show that FAIR could be used to study endplate perfusion. |
| 2262 | Computer 89
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Exercise-stimulated muscle hyperemia: a preliminary investigation with diffusion tensor imaging on calf muscles |
| Xin Mu1, Meng Tian2, Huahui Xu3, Chang Ni1, Yanbin Li4, Xiangwei Kong1, Xiaoli Gu3, and Jeff L Zhang1 | ||
1Vascular and Physiologic Imaging Research (VPIR) Lab, School of Biomedical Engineering, ShanghaiTech University, Shanghai, China, 2School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 3Department of Radiology, Shanghai Guanghua Hospital of Integrative Medicine, Shanghai, China, 4Central Research Institute, UIH Group, United Imaging Healthcare, Shanghai, China |
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Keywords: Skeletal, Muscle Diffusion tensor imaging (DTI) has been shown to be highly sensitive to subtle pathological alterations caused by multiple diseases. Utilizing this capability of DTI, in this study we characterized post-exercise hyperemic responses of calf muscles. We found that multiple DTI measures, including ADC, λ1-3, and RD, increased significantly in activated muscles, and more than in those in non-activated muscles. Of particular interest was the significant increase in λ3 and RD of the activated muscle, indicating a relatively higher degree of increase in water diffusion along the cross-section direction of muscle fibers. |
| 2263 | Computer 90
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Comparison of Penalty-based IVIM analysis Methods for Predicting Response to Neoadjuvant Chemotherapy in Osteosarcoma |
| Esha Baidya Kayal1, Devasenathipathy Kandasamy2, Kedar Khare1, Raju Sharma2, Sameer Bakhshi2, and Amit Mehndiratta1,2 | ||
1Indian Institute of Technology Delhi, New Delhi, India, New Delhi, India, 2All India Institute of Medical Sciences, New Delhi, India, New Delhi, India |
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Keywords: MSK, Cancer, Intravoxel Incoherent motion, Chemotherapy response prediction, Performance comparison Predictive performance of penalty-based IVIM analysis methodologies BE+TV and BE+HPF for response to Neoadjuvant Chemotherapy have been evaluated using clinical dataset with osteosarcoma in comparison with existing IVIM analysis methods. IVIM datasets before and after chemotherapy were analyzed using 5 IVIM analysis methods – Bi-exponential model and two of its segmented variants and penalty-based BE+TV and BE+HPF methods. Results showed, IVIM parameters estimated by BE+TV and BE+HPF methods produced improved prediction of response to chemotherapy in osteosarcoma than the existing IVIM analysis methods at both the time-points, before and after chemotherapy. |
| 2264 | Computer 91
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Radiomics based on conventional MRI sequences to differentiate inert fibrogenic tumors and invasive fibrogenic tumors of trunk and limbs |
| Peng Gao1, Weisheng Zhang1, and Hexin Feng2 | ||
1Dalian Medical University, Dalian, China, 2China Medical University, Shenyang, China |
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Keywords: Muscle, Tumor 区分不同亚型的纤维化肿瘤仍然具有挑战性，但具有重要的临床意义。本研究的目的是评估基于常规 MRI 序列的影像组学在区分惰性纤维化肿瘤和躯干和四肢浸润性纤维化肿瘤的价值。预测模型基于 T1 图像的逻辑回归在区分惰性纤维瘤和侵袭性纤维瘤方面具有最好的预测效率，对 T1 和 T2 预测模型贡献最大的特征分别是 idn 和最小轴长。病变的大小和深度对判断肿瘤的性质有一定的参考价值。 |
| 2265 | Computer 92
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Compressed SENSE AI enhanced mDixon-Quant MR Imaging in the Lumber Spine Study |
| Linzhe Li1, Junhong Duan1, Muqi Liu1, Yunjie Liao1, Pengzhi Hu1, and Chen Thomas Zhao2 | ||
1Department of Medical Imaging, the Third Xiangya Hospital, Central South University, Changsha, China, 2Philips Healthcare, Guangzhou, China |
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Keywords: MSK, Fat, CS AI, Bone Marrow Fat, mDIXON-quant Compressed SENSE (CS) has been suggested to speed up MRI acquisition in clinical studies, while reducing artefacts and improving image quality. To date, the optimal acceleration factor (AF) for Compressed SENSE AI (CS AI) versus conventional compressed SENSE (CS) on lumber spine images remains unclear. In this study, the impact of CS AI technique with different acceleration factors compared with conventional CS on the utility of measuring lumber spine fat was investigated. Results of this study showed that CS AI not only shortened MRI acquisition time, but also ensured image quality, as well as clinical diagnostic accuracy and clinical throughput. |
| 2266 | Computer 93
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Evaluating age-related changes of vascular function and oxidative energy metabolism in the lower leg during a plantar flexion exercise |
| Alfredo Liubomir Lopez Kolkovsky1, Béatrice Matot1, Harmen Reyngoudt1, Benjamin Marty1, Ericky Caldas de Almeida Araujo1, and Yves Fromes1 | ||
1NMR Laboratory , Neuromuscular Investigation Center, Institute of Myology, Paris Cedex 13, France |
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Keywords: Muscle, Aging, Multi-contrast, Metabolism, Non-proton, Spectroscopy The age-related loss of muscle mass, strength and quality is a multifactorial process whose mechanisms are incompletely understood. NMR allows investigating numerous physiological and biochemical variables in vivo dynamically. Here, 51 physically active subjects performed a normalized plantar flexion exercise to evaluate vascular response (blood flow, T2*, water compartmentalization), tissue oxygenation and oxidative energy metabolism (pH, mitochondrial oxidative capacity, work to [ADP] ratio). Results showed that the vascular and metabolic function was preserved in old subjects relative to young and middle-aged participants. We conclude that vascular and oxidative metabolism impairments are not a necessary condition of old age. |
| 2267 | Computer 94
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Deep learning reconstruction of zero echo time imaging: bone erosion detection in axial spondyloarthritis |
| Seok Hahn1, Jisook Yi2, Ho-Joon Lee2, Sunggun Lee3, Sekyoung Park4, Joonsung Lee5, Jose de Arcos6, and Maggie Fung7 | ||
1Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea, Republic of, 2Department of Radiology, IHaeundae Paik Hospital, Inje University College of Medicine, Busan, Korea, Republic of, 3Division of Rheumatology, Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea, Republic of, 4Department of Radiology, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea, Republic of, 5GE Healthcare, Seoul, Korea, Republic of, 6GE Healthcare, Little Chalfont, United Kingdom, 7GE Healthcare, New York, NJ, United States |
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Keywords: Joints, MSK, sacroiliac joint, zero echo time imaging, deep learning reconstruction The aim of this study was to compare the diagnostic performance of DLR of ZTE imaging for bone erosion in axial spondyloarthritis, using CT as the reference standard. Twenty-three patients with suspicion of sacroiliitis underwent both CT and MR scans of sacroiliac joints included for analysis. ZTE with or with DLR showed higher correlation coefficients than T1WI for two readers. Inter-reader agreements showed moderate to substantial agreement. ZTE DLR improves diagnostic performance in the detection of SIJ bone erosion in patients with axial spondyloarthritis compared with T1WI and ZTE without DLR. |
| 2268 | Computer 95
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Bone marrow fat composition assessed by fast and simple 1D MRS combined with intermolecular double-quantum coherence on 3.0 T |
| Jianfeng Bao1, Xiao Wang2, Yuchuan Zhuang3, Liangjie Lin4, Yong Zhang2, and Jingliang Cheng2 | ||
1Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, zhengzhou, China, 2Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 3Department of Electronic Science, University of Rochester, ROCHESTER, NY, United States, 4Philips Healthcare, Beijing, China |
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Keywords: Bone, Fat, intermolecular double-quantum coherence,fat composition,magnetic resonance spectroscopy Unsaturated fatty acids in the bone marrow may play a critical role in bone metabolism, however, these peaks cannot be well resolved by conventional MRS techniques due to local intensive B0 inhomogeneities. We introduced intermolecular double-quantum coherence to enhance the spectrum resolution on clinical 3.0 T within one minute and more unsaturated peaks can be identified. |
| 2269 | Computer 96
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DCE-MR Lymphangiography Demonstrates Significantly Different Lymphatic Drainage in Patients with a FOXC2 Gene Mutation Compared to Controls |
| Michael Mills1, Greta Brezgyte1, Bernard Ho2, Julian Pearce2, Kristiana Gordon1,2, Peter S Mortimer1,2, Pia Ostergaard1, and Franklyn A Howe1 | ||
1St George's University of London, London, United Kingdom, 2St George's University Hospitals NHS Foundation Trust, London, United Kingdom |
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Keywords: Vessels, Genetic Diseases, lymphatic MRI can investigate lymphatic dysfunction and lymphoedema (a chronic swelling of interstitial fluid), however little quantitative research has been published. Dynamic Contrast-Enhanced Magnetic Resonance Lymphangiography (DCE-MRL) allows identification of lymph vessels in both healthy and lymphoedematous limbs, and was used to study the oedematous limbs of patients where the lymphoedema was associated with a mutation of the FOXC2 gene. Signal measured in leg lymphatics of these patients (n=6) peaked significantly earlier than in non-oedematous limbs (n=6) and demonstrated higher peak signals, despite an impaired lymphatic system and therefore an expectation of more sluggish drainage. |
| 2270 | Computer 97
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Deep Learning Based on Knee MRI for Fully Automated Segmentation and Precision Diagnosis of Rheumatoid Arthritis, Gout and PVNS |
| Qizheng Wang1, Meiyi Yao2, Yandong Liu3, Xinhang Song2, Xiaoying Xing1, Yongye Chen1, Ke Liu1, Weili Zhao1, Xiaoguang Cheng3, Shuqiang Jiang2, and Ning Lang1 | ||
1Peking University Third Hospital, Beijing, China, 2Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China, 3Department of Radiology, Beijing Jishuitan Hospital, Beijing, China |
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Keywords: Joints, Segmentation Segmentation of synovial-related structures in MRI images can help assess synovitis-effusion, infrapatellar fat pad (IPFP) changes, and response to treatment, which is important for the clinical diagnosis of knee disease. However, segmenting images manually, which depends on the skill and experience of the physician; furthermore, it is time-consuming for radiologists. In this study, a deep learning pipeline for the 3D segmentation of the suprapatellar capsule (SC) and IPFP and knee synovitis classification were developed using proton density (PD)-weighted images of sagittal fat-suppressed knees, the most commonly used sequence in clinical practice, to support clinical decision-making. |
| 2271 | Computer 98
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Accurate and quantitative assessment of rheumatoid joint synovitis based on DCE-MRI pixel-level analysis |
| Jinling Mao1, Zhongqi Zhu1, Yinghao Li1, Hongzhi Wang1, and Jie Shi2 | ||
1East China Normal University, Shanghai, China, 2Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China |
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Keywords: Vessels, Inflammation, synovitis;Pannus;Wrist joint In this paper, 18 cases of wrist magnetic resonance enhancement were collected, a pixel-by-pixel time-intensity curves (TIC) analysis method was proposed, four types of enhancement curves were customized, and compared with the synovitis score, the results showed that the area of the rapidly rising and descending pixel area was extremely correlated with the synovitis score (r=0.812). |
| 2272 | Computer 99
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The value of zero echo time MR imaging for demonstrating bony change of sacroiliac joint in ankylosing spondylitis: a comparative study with CT |
| Ziwei Zhang1, Lingling Song1, Weixin He1, Qi Zeng1, Lisha Nie2, Xiaocheng Wei2, Jiawei Wang1, He Sui1, Zhaoshu Huang1, Xia Zhu1, Chen Liang1, and Yu Li1 | ||
1The Affiliated Hospital of Guizhou Medical University, GuiYang, China, 2GE Healthcare, MR Research China, BeiJing, China |
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Keywords: Skeletal, Skeletal The current study aims to compare the detection ability of zero echo time(ZTE) MRI and CT in presenting bony change of sacroiliac joint in ankylosing spondylitis. It was concluded that the ankylosing spondylitis detection rate was comparable between ZTE MRI and CT, where the detection rate of bony erosions by ZTE MRI was higher than that by CT. Our observations indicated that in the future, the ZTE MRI may potentially replace the ionization-related CT method by providing a more comprehensive evaluation of sacroiliitis in ankylosing spondylitis patients. |
| 2273 | Computer 100
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Prediction of Histopathological Subtypes of Dermatofibrosarcoma protuberans Based on MRI Radiomics Machine Learning Model |
| Siyu Liu1, Yishi Wang2, and Songtao Ai1 | ||
1Shanghai Ninth People's Hospital, Shanghai, China, 2Philips Healthcare, Beijing, China, Beijing, China |
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Keywords: Muscle, Cancer Dermatofibrosarcoma protuberans （DFSP） is a rare low to intermediate grade soft tissue sarcoma of skin, but the fibrosarcomatous DFSP （FS-DFSP） is a clearly malignant pathological subtype. The identification of malignant pathological subtypes by radiomics plays an important role preoperatively. The non-invasive machine learning method based on T1WI and FS-T2WI imaging is potential prognostic tool by distinguishing different levels of DFSP pathological subtypes before operation in this study to provide a new idea for the diagnosis and treatment of DFSP. |
| 2451 | Computer 101
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Intra- and Inter-vendor Reproducibility of T1ρ Measurements in the Healthy Human Knee Joint |
| Ryan Robert Armbruster1, Anjali Talluru2, Arijitt Barthakur3, Warren Bilker4, Ravinder Reddy3, and Susanta Sarkar5 | ||
1Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 2University of Pittsburg, Pittsburg, PA, United States, 3Radiology, University of Pennsylvania, Philadelphia, PA, United States, 4Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, United States, 5Cadenzamed LLC, Berwyn, PA, United States |
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Keywords: Cartilage, Osteoarthritis Osteoarthritis (OA) is a debilitating disease that results in cartilage loss and pain, but no drug is currently available for OA, largely due to the absence of a reliable index for measuring disease modifying effects of drug candidates in clinical trials. T1ρ MRI promises to be a reliable method because it provides a measure of cartilage degradation. However, it is critical to establish its reproducibility across MRI vendors before its universal use in clinical studies. Here we report the establishment of a clinically relevant reproducibility error in T1ρ in 25 healthy volunteer knees within and across 3T MRI scanners. |
| 2452 | Computer 102
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Ultrafast T2 mapping of knee articular cartilage under compression using a radial turbo-spin-echo sequence at 3T - initial results |
| Veronika Janacova1, Vladimir Juras 1, Pavol Szomolanyi1,2, Diana Bencikova1, and Siegfried Trattnig1,3,4,5 | ||
1High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, 3CD Laboratory for MR Imaging Biomarkers (BIOMAK), Vienna, Austria, 4Austrian Cluster for Tissue Regeneration, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria, 5Institute for Clinical Molecular MRI in the Musculoskeletal System, Karl Landsteiner Society, Vienna, Austria |
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Keywords: Cartilage, Quantitative Imaging, Ultra-fast Quantitative T2 maps have been used for more than a decade in musculoskeletal MR research as a tool for cartilage assessment. In this work, we compared T2 mapping of knee cartilage with ultrafast radial turbo-spin-echo sequence to conventional multi-echo spin echo sequence. We used radial turbo-spin-echo T2 maps to track dynamic changes in knee cartilage during compression. Correlation between the two methods was found in multiple cartilage regions. Dynamic change in T2 values was observable on T2 maps during first two minutes of compression. We demonstrated that radial-TSE sequence allows for fast determination of T2 values of the knee cartilage. |
| 2453 | Computer 103
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Associations between Weight Change, Knee Subcutaneous Fat and Cartilage Thickness: 4-Year Data from the OAI |
| Gabby B Joseph1, Melia Takakusagi1, Gino Arcilla1, John Lynch2, Valentina Pedoia1, Sharmila Majumdar1, Nancy E. Lane3, Michael C Nevitt2, Charles E McCulloch2, and Thomas M. Link1 | ||
1Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA, United States, 3Department of Rheumatology, UC Davis, Davis, CA, United States |
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Keywords: Osteoarthritis, Cartilage This study assessed the relationship between 4-year changes in: (1) body weight and outcomes of joint-adjacent subcutaneous fat (SCF) and cartilage thickness, and (2) joint-adjacent SCF and knee cartilage thickness. A total of 399 individuals from the Osteoarthritis Initiative with >10% weight gain and >-10% weight loss over 4 years were compared with controls with less than 3% weight change. Weight gain and loss were associated with increases, and decreases, respectively in joint-adjacent SCF. Increases in SCF adjacent to the medial femur were associated with decreases in average cartilage thickness and in several medial and lateral locations in the knee. |
| 2454
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Computer 104
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Preserved patellar cartilage at the expense of anterior femoral cartilage damage in Hip Osteoarthritis: An Inter-Limb Inter-Joint qMRI analysis |
| Rupsa Bhattacharjee1, Johanna Luitjens1, Misung Han1, Rafeek Thahakoya1, Koren E. Roach1, Richard B. Souza1,2, Valentina Pedoia1, and Sharmila Majumdar1 | ||
1Department of Radiology and Biomedical Imaging, University of California, San Francisco (UCSF), San Francisco, CA, United States, 2Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco (UCSF), San Francisco, CA, United States |
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Keywords: Cartilage, Osteoarthritis, Bilateral, Hip, Knee It is well documented that osteoarthritis often affects multiple joints in patients with the disease. However, direct associations between limbs and across the joints of the lower extremity remains understudied. With bilateral hip and knee MRI of 18 patients, this study utilizes automated segmentation and VBR-atlas-based methods to explore the associations between twelve femoral and acetabular sub-compartments with trochlear and patellar cartilage T1rho, T2 values. Significant negative correlations between the patellar T2 and anterior hip femoral T1rho and T2 values, suggest a probable ongoing gait dysfunction. The data-distribution indicates possibility of a subgroup of patients having different progression and compensatory trajectories, to be explored further with gait pattern analysis. |
| 2455 | Computer 105
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T1rho Sequences with FASE, UTE, and MAPSS Acquisitions for Knee Evaluation |
| Vadim Malis1, Yoshimori Kassai2, Mitsue Miyazaki1, and Won Bae1,3 | ||
1Radiology, University of California, San Diego, La Jolla, CA, United States, 2Canon Medical Systems Corp, Otawara, Japan, 3VA San Diego Healthcare System, San Diego, CA, United States |
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Keywords: Cartilage, Tissue Characterization, T1rho Three T1rho sequences based using 3D FASE, 3D UTE, and 3D MAPSS acquisitions were developed and compared by imaging agarose phantoms and normal human knees. The sequences utilize 4 to 6 spin lock times, and can be acquired in about 5 min or less. On phantoms, all three sequences resulted in consistent T1rho values that decreased with increasing agarose concentration, similar to past reports. T1rho values of cartilage and menisci were also in line with previously reported values. This work will be useful for evaluating knee osteoarthritis and other musculoskeletal diseases. |
| 2456 | Computer 106
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Assessing the effects of spin lock time duration on T1ρ relaxation times for imaging of the articular cartilage in the knee |
| ALLEN A CHAMPAGNE1, TAYLOR M ZULEGER2,3,4,5, DANIEL R SMITH2,4,5, ALEXIS B SLUTSKY-GANESH2,4,5,6, SHAYLA M WARREN2,4,5, LEXIE M SENGKHAMMEE2,4,5, SAGAR MANDAVA7, HONGJIANG WEI8, DAVIDE D BARDANA9, GREG D MYER2,4,5,10, and JED A DIEKFUSS2,4,5 | ||
1School of Medicine, Queen's University, Kingston, ON, Canada, 2Emory Sports Performance And Research Center, Flowery Branch, GA, United States, 3Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH, United States, 4Emory Sports Medicine Center, Atlanta, GA, United States, 5Department of Orthopaedics, Emory University School of Medicine, Atlanta, GA, United States, 6Department of Kinesiology, University of North Carolina at Greensboro, Greensboro, NC, United States, 7GE Healthcare, Atlanta, GA, United States, 8School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 9Department of Orthopaedics, Queen's University, Kingston, ON, Canada, 10The Micheli Center for Sports Injury Prevention, Waltham, MA, United States |
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Keywords: Cartilage, Quantitative Imaging, T1rho, knee There is limited standardization of T1ρ acquisition parameters with respect to spin lock times (TSLs). Shorter TSL durations are susceptible to underestimating knee cartilage T1ρ relaxation times, warranting optimization for maximal measurement stability. Additionally, vertical estimation of T1ρ relaxation times throughout cartilage layers is limited. Here, we utilized 40 healthy knees to demonstrate enhanced T1ρ relaxation time measurement stability with maximum TSLs of 90 to 120ms compared to shorter TSL durations. Depth-specific differences in T1ρ were further compartmentalized into deep and superficial knee cartilage layers, highlighting the potential for T1ρ to indirectly and non-invasively evaluate proteoglycan content across cartilaginous layers. |
| 2457 | Computer 107
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Deep-Learning-Based Knee Articular Cartilage Morphometrics |
| Yongcheng Yao1 and Weitian Chen1 | ||
1Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, Hong Kong |
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Keywords: Cartilage, Cartilage, morphometrics We proposed a deep-learning-based system for automatic knee articular cartilage morphometrics. It produces regional metrics including full-thickness cartilage loss (FCL), mean thickness, surface area, and volume. The proposed system comprises deep learning models and algorithms that work collaboratively. We have trained convolutional neural networks for tissue segmentation, template construction, and image registration. We designed modules and pipelines for cartilage thickness mapping, cartilage lesion quantification, and cartilage parcellation. Results shows superior accuracy of the thickness mapping method and robustness of the cartilage parcellation method. The proposed FCL estimation method filled the gap in automatic cartilage lesions quantification. |
| 2458 | Computer 108
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Meniscus UTE-T2* Measured Prior to Anterior Cruciate Ligament Reconstruction Predicts Radiographic Osteoarthritis 11 Years Later |
| Ashley A. Williams1, Nicholas P Drain2, Yongxian Qian3, Kathryn J. Stevens4, and Constance R. Chu1 | ||
1Orthopaedic Surgery, Stanford University, Stanford, CA, United States, 2Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, United States, 3Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 4Department of Radiology, Stanford University, Stanford, CA, United States |
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Keywords: Osteoarthritis, Relaxometry, UTE-T2*, meniscus, radiography This study examines whether compositional degeneration of the meniscus is a potential predictor of future radiographic knee OA. Mensical UTE-T2* maps acquired prior to anterior cruciate ligament reconstruction (ACLR) were compared to knee radiographs collected 11 years later in 11 ACLR patients. On average, pre-operative posterior medial and lateral meniscal UTE-T2* values were 39% and 33% higher in knees with KL grade ≥ 2 compared to knees with KL grades 0-1 at 11-year follow-up (p=0.016, 0.034). Thus, elevated meniscal UTE-T2* in the context of an ACLR knee may be a warning of increased risk for radiographic osteoarthritis many years later. |
| 2459 | Computer 109
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Enabling Early Detection of Knee Osteoarthritis Using Diffusion-Relaxation Correlation Spectrum Imaging |
| Peng Luo1, Wentao Hu2, Yongming Dai2, and Guanwu Li1 | ||
1Department of Radiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China, 2Central Research Institue, United Imaging Healthcare, Shanghai, China |
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Keywords: Cartilage, Diffusion/other diffusion imaging techniques Early OA is subclinical for anatomic change of cartilage, making it difficult for conventional MRI detection. This study is aimed to apply diffusion-relaxation correlation spectrum imaging (DR-CSI) to knee early-stage OA detection. DR-CSI compartment volume fractions VA, VB and VC had correlation with the modified Whole-Organ MR Imaging Scores (WORMS). VC had better ability than VA, VB, VD, T2 and ADC to discriminate early OA patients from healthy controls. The results illustrated that DR-CSI compartment volume fractions may be sensitive indicators for detecting early-stage degeneration in knee articular cartilage. |
| 2460 | Computer 110
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Preoperative Femoral Cartilage T2 Relaxation Time Predicts Change in PROs in Patients with Degenerative Meniscal Tears |
| Jessica Lauren Asay1, Anthony A Gatti1, Arjun D Desai1, Emily J McWalter2, Shannon N Edd3, Thomas P Andriacchi3, Nicholas J Giori4,5, and Garry E Gold1 | ||
1Radiology, Stanford University, Stanford, CA, United States, 2Mechanical Engineering and Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, 3Mechanical Engineering, Stanford University, Stanford, CA, United States, 4VA Palo Alto Health Care System, Palo Alto, CA, United States, 5Orthopedic Surgery, Stanford University, Stanford, CA, United States |
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Keywords: Cartilage, Joints, Meniscus, Knee, Patient Reported Outcomes Meniscectomies are common but not always successful in treating degenerative meniscus tears. Preoperative patient reported outcomes (PROs) and quantitative MRI could help surgeons decide candidacy for meniscectomy. This study demonstrated that pre-operative T2 relaxation times in the medial central femoral cartilage are correlated to pre-operative PROs in patients with degenerative meniscal tears and are predictive of 1 and 2-year changes in PROs post-operation. This study suggests patients who have longer T2 relaxation times pre-operation might not benefit as much from a meniscectomy. |
| 2461 | Computer 111
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Water content and T2 changes in ex vivo bovine knee cartilage under compressive strain |
| Andrew C Yung1, Emily Sullivan2,3, Jessica C Küpper2,4, Kirsten Bale1, Piotr Kozlowski1, and David Wilson2,4 | ||
1UBC MRI Research Centre, Radiology, University of British Columbia, Vancouver, BC, Canada, 2Centre for Hip Health and Mobility, Vancouver, BC, Canada, 3School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, 4Orthopaedics, University of British Columbia, Vancouver, BC, Canada |
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Keywords: Cartilage, Osteoarthritis, Strain We present a novel approach to cartilage multi-echo data where T2 reflects focal changes in strain along the cartilage depth, and the signal amplitude reflects a measure of water content which presents a simpler pattern of change that reflects strain. Ex vivo bovine knee samples were scanned at 9.4T while under load, with high resolution along the cartilage depth to allow direct measurement of strain. Changes in water content were found to be more spatially uniform than the complex depth dependence shown by T2, and showed a high degree of correlation to whole-cartilage averages of bulk strain. |
| 2462 | Computer 112
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Evaluation of whole compartment and regional meniscal T2* values within elite athletes |
| Erin C Argentieri1, Sara E Sacher1, Ek Tsoon Tan1, Garry Gold2, Hollis G Potter1, Sharmila Majumdar3, and Matthew F Koff1 | ||
1Radiology and Imaging, Hospital for Special Surgery, New York, NY, United States, 2Stanford University, Stanford, CA, United States, 3University of California San Francisco, San Francisco, CA, United States |
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Keywords: Cartilage, Quantitative Imaging Results of the current study demonstrate compartment- and region-specific differences in medial and lateral meniscal T2* values. Meniscal T2* values may provide a non-invasive means to assess response of the tissue specific to the loading environment and identify the early onset meniscal degeneration. A better understanding of the early changes in meniscal T2* values may help define the progression of meniscal degeneration, prior to the onset of gross morphologic defects. |
| 2463 | Computer 113
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Evaluation of the relationship between meniscal T2* metrics and tibial bone shape |
| Erin C Argentieri1, Kenneth Gao1, Valentina Pedoia1, Garry Gold2, Matthew F Koff3, Hollis G Potter3, and Sharmila Majumdar1 | ||
1Radiology, University of California San Francisco, San Francisco, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States, 3Radiology and Imaging, Hospital for Special Surgery, New York, NY, United States |
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Keywords: Cartilage, MSK Features of tibial bone morphology such as tibial slope and tibial spine volume have a significant impact on overall joint mechanics and, results of the current study indicate that these feature of tibial bone shape impact both medial and lateral meniscal T2* metrics. |
| 2464 | Computer 114
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Quantitative assessment of the adipose tissue around the knee joint in patients with KOA using IDEAL-IQ and T2 mapping sequences with 3.0 T MRI |
| Lin Qiu1, Long Qian2, and Xiang-Ran Cai1 | ||
1Medical Imaging Center, First Affiliated Hospital, Jinan university, Guangzhou, China, 2MR Research, GE Healthcare, Guangzhou, China |
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Keywords: Cartilage, Osteoarthritis IDEAL-IQ and T2 mapping sequences are capable of objectively assessing fat and water content in the adipose tissue around the knee joint. The severity of KOA is related to the fat and water content of knee adipose tissue. |
| 2465 | Computer 115
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Scan-Rescan Repeatability of 10-Minutes Long MAPSS Sequence for Simultaneous MR T2 and T1ρ Mapping of Cartilage and Meniscus at 7 Tesla |
| Stefan Zbyn1,2,3, Richard Lartey1,2, Jeehun Kim1,2, Carl S. Winalski1,2,3, and Xiaojuan Li1,2,3 | ||
1Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, United States, 2Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States, 3Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States |
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Keywords: Cartilage, Relaxometry, Meniscus The aim of this study was to evaluate the in vivo scan-rescan repeatability of T2 and T1ρ quantification in knee cartilage and meniscus of patients with knee pain at 7 Tesla. Four subjects were scanned-rescanned on the same day using the 10-minutes-long MAPSS sequence for simultaneous T2 and T1ρ mapping. Coefficients of variation and Bland-Altman plots showed excellent scan-rescan repeatability of in vivo T2 and T1ρ quantification in cartilage and meniscus at 7 Tesla. Our results indicate that fast T2 and T1ρ mapping with four echo and four spin-lock times remains sensitive to cartilage degeneration. |
| 2466 | Computer 116
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Bi-exponential 3D UTE-T1rho relaxation mapping of ex-vivo human knee patellar tendon at 3T |
| Bhavsimran Malhi1, Dina Moazamian1, Michael Carl2, Jiyo Athertya1, Saeed Jerban1, Hyungseok Jang1, Yajun Ma1, Eric Chang1,3, and Jiang Du1,4,5 | ||
1Department of Radiology, University of California, San Diego, USA, San Diego, CA, United States, 2GE Healthcare, San Diego, USA, San Diego, CA, United States, 3Veterans Affairs San Diego Helath Care system, San Diego, USA, San Diego, CA, United States, 4Veterans Affairs San Diego Health Care System, San Diego, CA, USA, San Diego, CA, United States, 5Department of Bioengineering, University of California, San Diego, USA, San Diego, CA, United States |
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Keywords: Tendon/Ligament, Tendon/Ligament, UTE, MRI UTE sequences have been previously used to image short T2 tissues. T1ρ has shown promising results in assessing macromolecules and has been proposed as a potential biomarker for tissue degeneration. In this study, we aimed to demonstrate bi-exponential relaxation of the patellar tendon at 3T, using the 3D ultrashort echo time T1ρ (UTE-T1ρ) sequence. Five ex-vivo knee joints were scanned, and we were able to demonstrate better fitting with a bi-component model and better discern the long and short relaxation components of the tissue, along with their respective fractions |
| 2467 | Computer 117
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QRAPMASTER for Quantitative evaluation of knee cartilage: ready for clinical daily practice? |
| Lin Mu1, Qianting Wang1, Jiahui Fu2, Dong Dong2, Yueluan Jiang3, Lin Li4, and Huimao Zhang2 | ||
1The First Hospital of Jilin University, Changchun, China, 2Radiology, The First Hospital of Jilin University, Changchun, China, 3MR Scientific Marketing, Diagnostic Imaging, Siemens Healthineers Ltd, Beijing, China, 4Radiology, The First Hospital of Jilin University, changchun, China |
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Keywords: Cartilage, MSK Quantitative MRI assigns absolute quantification of T1,T2 and PD based on tissue characteristics, such as the T2 metric values a surrogate marker for cartilage collagen integrity. The QRAPMASTER technology enables inline generation of quantitative T1maps and T2 maps and scans of high image quality, representing a promising synthetic MRI option that appears clinically feasible and may eventually facilitate the time neutral acquisition of quantitative T1 maps, T2 maps in the knee MRI. |
| 2468 | Computer 118
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Generalizability of nnU-Net for automatic segmentation of knee MRI |
| Heather Hanegraaf1, Rianne A. van der Heijden1,2, Edwin H.G. Oei1, Marienke van Middelkoop3, Stefan Klein1, and Jukka Hirvasniemi1 | ||
1Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, Netherlands, 2Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Department of General Practice, Erasmus MC University Medical Center, Rotterdam, Netherlands |
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Keywords: Osteoarthritis, Segmentation To investigate the generalizability of deep learning segmentation models, three different nnU-Nets (2D, 3D, and ensemble) were trained on the OAI dataset and tested on a different dataset. In addition to the nnU-Nets trained on the original OAI data, the style of the test set was transferred to the training set using a CycleGAN method and the nnU-Nets were trained again. Depending on the tissue, the 3D nnU-Net or the ensemble trained on the original or stylized training data had the highest segmentation accuracy in the test set. The results indicate that nnU-Net may generalize well to independent datasets. |
| 2469 | Computer 119
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Automated Deep Learning Segmentation of Human Knee Cartilage from 3T MRI with Boundary Information |
| Zhisen Hu1, Peter J Lally1, and Neal K Bangerter1 | ||
1Department of Bioengineering, Imperial College London, London, United Kingdom |
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Keywords: Osteoarthritis, Segmentation Knee Osteoarthritis (OA) is serious and prevalent today. Image segmentation of high-resolution MRI scans measuring cartilage volume and thickness is useful to track knee OA progression in the early stages and avoid joint replacement. In this work, we developed a cheap and efficient automated technique based on U-Net for knee cartilage segmentation, paying more attention to boundary information. Our model outperforms many existing models for segmentation of the femoral cartilage and performs as well as other techniques for other cartilage compartments. The boundary loss appears to improve cartilage segmentation for the edge slices with smaller cartilage volume. |
| 2470 | Computer 120
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Ultrashort Echo Time Magnetization Transfer Imaging of Meniscus After a Marathon |
| Yijie Fang1, Dantian Zhu1, Wenhao Wu1, Shaolin Li1, Long Qian2, and Yajun Ma3 | ||
1Department of Radiology,Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, China, 2MR Research, GE Healthcare, Beijing, China, 3University of California, San Diego, Department of Radiology, San Diego, CA, United States |
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Keywords: MSK, Joints In this study, a 3D UTE-MT preparation will be used to detecting changes in the meniscus of amateur marathon runners before and after a marathon. In this prospective cohort study, 23 amateur marathon runners were enrolled. There were three MRI scans (pre-race, 2 days post-race, and 4 weeks post-race) using the UTE-MT and UTE-T2* sequences. UTE-MTR values decreased 2 days post-race and increased after 4 weeks of rest. Conversely, the UTE-T2* values increased 2 days post-race and increased after 4 weeks of rest. UTE-MTR is a promising biomarker for the detection of changes in the meniscus after a marathon. |
| 2588
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Computer 61
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Phase contrast motor unit MRI (PC-MUMRI) to investigate changes to muscle twitch dynamics in a healthy ageing cohort |
| Matthew G. Birkbeck 1,2,3, Linda Heskamp1, Ian S. Schofield1, Julie Hall4, Roger G. Whittaker1, and Andrew M. Blamire1 | ||
1Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom, 2NIHR Biomedical Research Centre, NIHR Biomedical Research Centre, Newcastle upon Tyne, United Kingdom, 3Northern Medical Physics and Clinical Engineering, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, 4Department of Neuroradiology, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, United Kingdom |
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Keywords: Muscle, Aging Functional changes to the muscle’s contractile and relaxation properties occur with age. Current techniques which measure twitch dynamics provide limited information about individual muscles. We used phase contrast motor unit MRI (PC-MUMRI) to non-invasively measure the contraction and relaxation times of lower leg muscles in a healthy ageing cohort, relating this to isometric maximum voluntary contraction (MVC). Contraction and relaxation times increased with ageing and were negatively correlated with MVC. PC-MUMRI offers a sensitive method to measure muscle twitch dynamics and could be combined with other MR techniques to characterise functional changes to muscle with ageing. |
| 2589 | Computer 62
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High temporal resolution dynamic 23Na-MRI in skeletal muscle following exercise |
| Mary A Neal1,2, Isobel K Townsend1,2, Harry Wightman1,2, and Peter E Thelwall1,2 | ||
1Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom, 2Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom |
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Keywords: Muscle, Non-Proton, 23Na, Sodium Atypical Na+ regulation following exercise can be indicative of skeletal muscle dysfunction. Dynamic 23Na-MRI of signal recovery following exercise therefore holds potential to provide a sensitive, quantitative, and non-invasive tool for physiological monitoring of disease progression or response to interventions. 23Na-MRI sequences with temporal resolutions ranging from 2-8 minutes were acquired in the lower leg before and repeatedly after strenuous isometric dorsiflexion. Our data characterised sodium dynamics during recovery from exercise, and demonstrated an initial increase in 23Na signal intensity from baseline levels after exercise ceased. These findings may provide additional metrics for monitoring skeletal muscle dysfunction. |
| 2590 | Computer 63
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A novel registration strategy to transform skeletal muscle architecture during passive shortening |
| Melissa T. Hooijmans1,2,3, Carly Lockard2, Crystal Coolbaugh1, Mark George1, Xingyu Zhou1,2,4, and Bruce Damon1,2,4 | ||
1Institute of Imaging Sciences, Vanderbilt University, Nashville, TN, United States, 2Carle Health, Stephens Family Clinical Research Institute, Urbana, IL, United States, 3Radiology and Nuclear Medicine, University of Amsterdam, Amsterdam Movement Sciences, Amsterdam UMC, Amsterdam, Netherlands, 4Biomedical Engineering, Vanderbilt University, Nashville, TN, United States |
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Keywords: Muscle, Diffusion Tensor Imaging, Muscle architecture In this study we explored if displacement fields, derived from registration of high-resolution anatomical images in different foot positions, could be used to transform muscle fiber architecture from plantar-flexed to dorsi-flexed foot position (passive shortening). Our data revealed that muscle fiber architecture from one foot position can be transformed in the other foot position and that the original and transformed fibers demonstrate similar architectural characteristics, i.e. fiber lengths, pennation angle, curvature, and physiological cross-sectional area. |
| 2591 | Computer 64
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Evaluation of the peripheral nerves of the knee using Double-Echo Steady-State MRI at 7T |
| Pinzhen Chen1, Zhiming Zhen2, Ting Yin3, and Wei Chen2 | ||
1The first affiliated hospital ofArmy Medical University, Chongqing, China, 2The first affiliated hospital, Army Medical University, Chongqing, China, 3MR Collaborations, Siemens Healthineers Ltd., Chengdu, China |
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Keywords: MSK, Nerves, 7T, DESS, peripheral nerves This study investigated the feasibility of DESS sequence to assess the knee peripheral nerve structures in healthy subjects and patients. The results showed that the nerve imaging quality of DESS sequence was superior to PD sequence in healthy adults. Further, only the isotropic 3D-DESS protocol could clearly visualize the distal peroneal nerve branches and their anatomical course. In patient with peripheral nerves damages, combining the PD and DESS imaging could provide more pathological and anatomical information about the knee peripheral nerve. This suggests that DESS sequence can reliably image the knee peripheral nerves and effectively provide precise knowledge about it. |
| 2592 | Computer 65
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Multi-parametric measures of in-vivo T2* mapping with δUTE and macromolecule exchange ZAP/CEST of cartilage, tendon, and muscle tissue in foot. |
| Vadim Malis1, Won Bae1,2, Diana Vucevic1, Yoshimori Kassai3, and Mitsue Miyazaki1 | ||
1Radiology, UC San Diego, San Diego, CA, United States, 2VA San Diego Healthcare System, San Diego, CA, United States, 3Canon Medical, Ōtawara-shi, Japan |
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Keywords: Tendon/Ligament, CEST & MT, UTE, Ultra-short TE A δUTE sequence allows for collecting multiple echoes with short echo time intervals, without the restriction of in-phase TEs. This study utilizes data collected with δUTE for bi-exponential T2* mapping of cartilage, muscle and tendon tissues in a human foot. The same anatomies are also evaluated using Z-spectrum Analysis Protons (ZAP) and Chemical exchange saturation transfer (CEST). While ZAP imaging provides overall exchange proton quantification of free and restricted exchange protons in a wide range of frequencies, CEST focuses on specific hydroxy (-OH, at 1.0 ppm), amine (-NH2, at 2 ppm), and amide (-NH, at 3.5 ppm) protons. |
| 2593 | Computer 66
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Feasibility of high-resolution multi-shot DW-EPI for DTI of peripheral nerves in the knee |
| Daehyun Yoon1, Brian Hargreaves1, and Amelie Lutz1 | ||
1Radiology, Stanford University, Stanford, CA, United States |
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Keywords: Neurography, Diffusion Tensor Imaging, Multi-shot DW-EPI, repeatability, feasibility DTI of peripheral nerves for detecting nerve damage has been very challenging due to limited resolution and imaging artifacts of the conventional single-shot diffusion-weighted echoplanar imaging (SS-DW-EPI). Here, we have evaluated the feasibility of improved DTI with multi-shot DW-EPI (MUSE) by comparing mean diffusivity (MD) and fractional anisotropy (FA) estimates of tibial and peroneal nerves with those from SS-DW-EPI in ten healthy subjects. MUSE showed lower within-subject coefficient of variation in diffusion estimates, indicating improved repeatability, while correlation analysis showed noticeable differences between FA estimates. Our results show the feasibility of MUSE for in vivo evaluation of peripheral nerves. |
| 2594 | Computer 67
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MRI monitors the abnormal muscle glycogen and creatine kinase activity in Pompe disease mice |
| Shaowei Bo1,2, Chongxue Bie1,3, Nirbhay N. Yadav4,5, Peter C.M. van Zijl4,5, Jiadi Xu4,5, Chao Zou1, Hairong Zheng1, and Yang Zhou1 | ||
1Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, China, 3Department of Information Science and Technology, Northwest University, Xian, China, 4F.M Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States |
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Keywords: Muscle, CEST & MT Pompe disease (PD) is a glycogen storage disease, characterized by progressive lysosomal glycogen accumulation and changes in energy metabolite levels. There is a lack of methods to noninvasively assess PD progression and treatment response. We demonstrate that saturation transfer MRI can detect changes in glycogen, total creatine (tCr), and phosphocreatine (PCr) in a mouse model of PD and show more than doubling of muscle glycogen levels and a gradual decrease of tCr and PCr levels with age. The simultaneous mapping of these energy metabolites with MRI has potential to assess PD and other diseases involving mitochondrial or energy metabolic disorders. |
| 2595 | Computer 68
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Feasibility study of paraspinal muscle fat infiltration assessed by lumbar disc degeneration grade |
| Jiujun Lan1, Wei Wang1, Xiaocheng Wei2, and Junrong Chen1 | ||
1Sichuan Province Orthopedic Hospital, Chengdu, China, 2GE Healthcare China, Beijing, China |
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Keywords: Muscle, Fat, Quantitative imaging, Lumbar disc herniation Previous study found that low back pain (LBP) and Modic changes were closely associated with fatty infiltration and cross-sectional area (CSA) of the paraspinal muscles. However, conflicting evidences were reported. This study investigated the association between intervertebral discs degeneration and lumbar paraspinal muscles CSA and fat infiltration, and explored the relationship between Modic change and intervertebral discs degeneration. Our results found that lumbar disc’s Pfirrmann grading was weakly correlated with CSA of multifidus, fat fraction of multifidus and erector spinae, and the incidence rate of Modic changes increased in higher Pfirrmann grading. |
| 2596 | Computer 69
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Decipher the simultaneous progress of fat infiltration and muscle atrophy with fat-clustering analysis of MRI |
| Xin Mu1, Huahui Xu2, Jialin Wang3, Chang Ni1, Meng Tian4, Xiaoli Gu2, and Jeff L Zhang1 | ||
1Vascular and Physiologic Imaging Research (VPIR) Lab, School of Biomedical Engineering, ShanghaiTech University, Shanghai, China, 2Department of Radiology, Shanghai Guanghua Hospital of Integrative Medicine, Shanghai, China, 3Central Research Institute, UIH Group, Central Research Institute, UIH Group, Shanghai, China, 4School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China |
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Keywords: Osteoarthritis, Aging Fat content and clustering are linked to muscle function in various disorders and are of therapeutic importance because they reflect the physical activity. Thus, we studied the fat content and clustering in three groups: hip-joint replacement surgery (HJRS) patients, ankylosing spondylitis (AS) patients who received medicine, and healthy controls. Although the intramuscular fat of unaffected side remained same in HJRS patients, Moran's index declined. Meanwhile, the Moran index of HJRS patients' affected side decreased significantly when fat content decreased. Besides, the drug treatment for AS patients resulted in a decrease in both fat content and Moran's index. |
| 2597 | Computer 70
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Feasibility of muscle template creation using tensor based registration |
| Martijn Froeling1 | ||
1Radiology, UMC Utrecht, Utrecht, Netherlands |
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Keywords: Muscle, Diffusion Tensor Imaging In this study, the aim is to show the feasibility of generating a per-muscle architecture template using a combination of muscle shape and muscle tensor registration. Additionally, the use of a generalized muscle template to identify between-subject differences will be explored. The tensor-based registration does allow for better alignment of internal muscle structures which is not possible using registration based on distance maps alone. |
| 2598 | Computer 71
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Magnetic-Resonance Tag Imaging of Cervical Spinal-Cord Motion in Patients with Segmental Stenosis |
| Constantin von Deuster1,2, Shila Pazahr3, Nikolai Pfender4, Armin Curt4, Reto Sutter3, and Daniel Nanz2 | ||
1Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Zurich, Switzerland, 2Swiss Center of Musculoskeletal Imaging, Balgrist Campus AG, Zurich, Switzerland, 3Radiology, Balgrist University Hospital, Zurich, Switzerland, 4Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland |
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Keywords: MSK, Skeletal, Spine, Tagging The reference standard for spinal-cord motion measurement is phase-contrast (PC) imaging. This approach, however, requires a dedicated phase correction during post processing, which renders clinical application very challenging. The objective of this work was to employ MR-tag imaging to directly visualize cervical spinal-cord motion in patients with spinal-canal stenosis and compare results with PC imaging. Among all patients, a good correlation between tag imaging and matched PC measurements was found (R2 = 0.84). Hence, MR-tag imaging may well complement standard static imaging within clinical routine of patients with spinal-canal stenosis, reflecting dynamic spinal cord distress. |
| 2599 | Computer 72
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Quantitative assessment of longitudinal changes in intervertebral discs |
| L. Tugan Muftuler1, Brendan Bych1, Jeffrey A. King1, and Jordan A. Gliedt1 | ||
1Medical College of Wisconsin, Milwaukee, WI, United States |
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Keywords: Skeletal, Degenerative, intervertebral disc Chronic low back pain is usually associated with degeneration of the intervertebral discs, although the disc itself may not be the source of pain. Unfortunately, there are no objective measures of the disc degeneration process. The gold standard relies on visual assessment of MRI scans, which may not capture complex physiological changes in degenerating discs. We used quantitative MRI metrics to study longitudinal changes disc degeneration over a period of 2 years. Although most subjects did not show visible changes in discs, there were significant losses in disc height and some discs also showed a reduction in ADC and T1ρ. |
| 2600 | Computer 73
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Automated quantification of intervertebral disc volume loss, ADC and normalized T2 using convolutional neural networks |
| L. Tugan Muftuler1, Tomas Rokos2, Srivishnu Appalaraju2, Tyler Tran2, Joshua Goldshteyn2, Garin Jankowski2, and John Bukowy2 | ||
1Medical College of Wisconsin, Milwaukee, WI, United States, 2Milwaukee School of Engineering University, Milwaukee, WI, United States |
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Keywords: MSK, Quantitative Imaging, spine, lumbar, intervertebral disc degeneration Intervertebral disc degeneration is the leading cause of chronic low back pain (CLBP). However, there are no objective measures of the disc degeneration process. The current gold standard for grading disc degeneration relies on visual assessment of discs using MRI, which may not adequately capture complex physiological changes in degenerating discs. We developed a deep convolutional neural network to automatically segment vertebral structures and calculate quantitative MRI metrics. Results show significant changes in ADC and normalized T2 values with disc volume loss. |
| 2601 | Computer 74
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T1rho Dispersion in Proteoglycan-depleted Swine Spine Disc |
| Mitchell J. Christiansen1,2, Mark C. Preul3, Steven Marsh3, Jay D. Turner4, Juan Uribe4, Muhammad Nadeem2, Elliott J. Mufson2, Richard D. Dortch2, John C. Gore5, and Ping Wang2 | ||
1Creighton University School of Medicine, Phoenix, AZ, United States, 2Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States, 3Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, United States, 4Sonntag Spine Center, Barrow Neurological Institute, Phoenix, AZ, United States, 5Radiology and Radiological Sciences, Vanderbilt Institute of Imaging Science, Nashville, TN, United States |
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Keywords: MSK, Degenerative, Intervertebral disc T1rho imaging has been used to probe relatively slow macromolecular processes, making it a practical tool to gain information about water spin dynamics and interactions with endogenous macromolecules. We measured the dispersion of T1rho with different spin-lock fields in the intervertebral disc of swine spine specimens before and after the treatment to induce proteoglycan loss, a sign of early disc degeneration. Analysis revealed elevated T1rho values in all proteoglycan-depleted discs at each spin-lock field, and that post-treatment T1rho changes increase at a higher spin-lock field. |
| 2602 | Computer 75
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Assessment of Rabbit Intervertebral Disc Degeneration Using Quantitative MR Imaging |
| Jiyo S Athertya1, James Lo1,2, Alicia Ji1, Charles Ding1, Arya Suprana1,2, Kiersten Red3, Yujia Ge3, Madeline Brown 3, Jiang Du1,2,4, Eric Y Chang1,4, Koichi Masuda 3, and Yajun Ma1 | ||
1Radiology, UC San Diego, San Diego, CA, United States, 2Bioengineering, UC San Diego, San Diego, CA, United States, 3Orthopedic Surgery, UC San Diego, San Diego, CA, United States, 4Radiology, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States |
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Keywords: MSK, Joints, Intervertebral disc Intervertebral disc degeneration is a leading cause of disability. In this study, quantitative T2 and ultrashort echo time magnetization transfer ratio (UTE-MTR) measurement techniques are utilized to assess biochemical component changes for better understanding of the mechanism of disc degeneration using a rabbit spinal intervertebral disc degeneration model. Both T2 and UTE-MTR values of nucleus pulposus (NP) are significantly different between normal and degenerated discs, indicating water and/or proteoglycan content changes. |
| 2603 | Computer 76
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Deep Learning Reconstructed T2-weighted Dixon Imaging of the Spine: Impact on Acquisition Time and Diagnostic Performance |
| Thierno D. Diallo1, Zeynep Berkarda1, Simon Wiedemann1, Caroline Wilpert1, Ralph Strecker2, Gregor Koerzdorfer3, Dominik Nickel3, Fabian Bamberg1, Matthias Benndorf1, and Jakob Weiß1 | ||
1Radiology, University Medical Center Freiburg, Freiburg, Germany, 2EMEA Scientific Partnerships, Siemens Healthcare GmbH, Erlangen, Germany, 3MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany |
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Keywords: MSK, Machine Learning/Artificial Intelligence Magnetic resonance imaging of the spine is considered one of the most commonly performed examinations in clinical routine. The raising demand for high quality imaging of the spine creates the need for tailored examination protocols, especially with regard to increasingly limited scanner capacities. Deep Learning based imaging reconstruction has emerged as promising novel technique to accelerate MR imaging while maintaining image quality. This study analyzed a novel deep learning accelerated T2-weighted Dixon sequence of the spine in terms of diagnostic performance. The results suggest that the here presented sequence is feasible with a diagnostic performance comparable to standard imaging. |
| 2604 | Computer 77
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Deep learning system for automated detection of posterior ligamentous complex injury in patients with thoracolumbar fracture on magnetic resonance imaging |
| Sang Won Jo1, Eun Kyung Khil1, Seun Ah Lee1, Jihe Lim1, Jae Hyeok Lee2, and Yu Sung Yoon3 | ||
1Radiology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea, Republic of, 2Deepnoid, Seoul, Korea, Republic of, 3Radiology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea, Republic of |
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Keywords: MSK, Machine Learning/Artificial Intelligence, thoracolumbar fracture This study was aimed to develop a deep learning algorithm for automated detection and localization of posterior ligamentous complex (PLC) injury on magnetic resonance imaging and evaluate its diagnostic performance. The sensitivity, the specificity and AUC of inception-ResNet V2 architecture of second step were 88%, 82% and 0.928, for the internal test set and 86%, 74% and 0.916 for the external test set, respectively. A deep learning algorithm detected PLC injury in patients with thoracolumbar fracture with a high diagnostic performance which was validated using external data set. |
| 2605 | Computer 78
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A pilot study of quantitative T2* mapping in intervertebral lumbar disc patients with lower back pain |
| Adiraju Karthik1, Apoorwa Devappa2, Aakaar Kapoor3, Dharmesh Singh4, and Dileep Kumar4 | ||
1Department of Radiology, Sprint Diagnostics, Jubilee Hills, Hyderabad, India, 2Department of Radiology, Mahadevappa Rampure Medical College, Kalaburagi, India, 3Department of Radiology, City X-Rays Scan & Clinical Private Limited, New Delhi, India, 4Central Research Institute, Global Scientific Collaborations, United Imaging Healthcare, New Delhi, India |
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Keywords: Skeletal, Spinal Cord, Intervertebral lumbar disc patients , T2* mapping The human lumbar spine is comprised of multiple tissue components that serve to offer structural stability as well as optimal nutrition. Traditional magnetic resonance (MR) imaging techniques have been beneficial in assessing intervertebral disc (IVD). Quantitative T2* mapping has recently been used to diagnose and characterize abnormalities associated with IVD, particularly water content variations. However, this approach remains in research settings, and its clinical application has not been thoroughly investigated. This study quantitatively evaluate the clinical value of T2* mapping of intervertebral lumbar disc patients with lower back pain using 3T magnetic resonance imaging (MRI). |
| 2606 | Computer 79
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Association of Lumbar Trabecular Bone Ultrashort Echo Time Magnetization Transfer Ratio (UTE-MTR) with Intervertebral Disc Degeneration |
| Jian-Bang Zhang1, Jin Liu1, Jia-Xin Feng1, Jianwei Liao1, Wei Li1, Xiao-Jun Chen1, Long Qian2, Ya-Jun Ma3, and Shao-Lin Li1 | ||
1Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China, 2GE Healthcare, Beijing, China, 3Department of Radiology, University of California San Diego, San Diego, CA, United States |
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Keywords: Bone, Skeletal Ultrashort echo time magnetization transfer (UTE-MT) technique can non-invasively quantify the macromolecular component changes. It has great potential to assess intervertebral disc degeneration (IVDD). In this study, we utilized the UTE-MT sequence to investigate the relationship between UTE-MT ratio (UTE-MTR) measurements of lumbar trabecular bone and IVDD. We found that the lumbar trabecular bone UTE-MTR negatively correlated with the IVDD grading. It demonstrates that the UTE-MTR of lumbar trabecular bone may serve as a useful biomarker to assess IVDD. |
| 2607 | Computer 80
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Lumbar spine disc degeneration assessed by in vivo 3T multifrequency MR elastography |
| Rolf Reiter1,2, David Kaufmann3, Mehrgan Shahryari1, Janosch Simon Jahn1, Rebecca Strehle1, Christian Bayerl1, Bernd Hamm1, Jürgen Braun4, Ingolf Sack1, and Patrick Asbach1 | ||
1Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2BIH Biomedical Innovation Academy, BIH Charité Digital Clinician Scientist Program, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany, 3Radiology, Universitätsklinikum Augsburg, Augsburg, Germany, 4Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany |
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Keywords: Elastography, MSK Despite the success in detecting intervertebral disc degeneration with high-resolution T2 sequences, conventional MRI is limited by large inter-reader variability as well as lacking stratification of clinical trials and their assessment of treatment responses. Several studies have shown the technical feasibility of MR elastography for the study of the intervertebral disc, but its clinical relevance remains unclear. This study shows an excellent diagnostic performance of high-resolution multifrequency MR elastography in the evaluation of lumbar spine intervertebral disc degeneration. |
| 2764 | Computer 61
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Sensitivity of Bi-Exponential UTE-T2* Mapping to Tendon Laxity |
| Ananya Goyal1, Marco Barbieri1, Valentina Mazzoli1, and Feliks Kogan1 | ||
1Radiology, Stanford University, Stanford, CA, United States |
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Keywords: Tendon/Ligament, Quantitative Imaging, T2*, Bi-exponential, UTE, CONES Tendon laxity can cause pain and increased injury risk. Quantitative MRI using Ultrashort echo time (UTE) sequences can quantify both short and long T2* water components in tendons. This study evaluates the sensitivity of UTE-T2* mapping with a bi-exponential fit model to tendon laxity, in the Achilles tendon under tension and relaxation. T2*long values seemed to increase as tendon load increased, while T2*short values were the opposite. These changes may be caused by water movement due to loading and changes in fiber orientation due to tendon slackening. |
| 2765 | Computer 62
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Synthetic MRI in the assessment of the classification of rotator cuff injury |
| Ni Yabo1, Wang zhijun1, and Tian Zhaorong2 | ||
1Ningxia Medical University General Hospital Radiology department, Yinchuan, China, 2Ningxia Medical University General Hospital Radiology department, Yinchuan, China, Yinchuan, China |
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Keywords: Tendon/Ligament, Quantitative Imaging In this study,to investigate the diagnostic value of quantitative parameters of synthetic magnetic resonance image in the grade of rotator cuff injury , we found that the T2 values had high diagnostic efficacy in grading the degree of rotator cuff injury, especially the T2 values of the lateral subregion and the middle subregion had high diagnostic efficacy in differentiating complete tears from partial tears, tendinopathy and normal tendons. |
| 2766 | Computer 63
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MRI and Ultrasound of lower extremity subcutaneous adipose tissue: potential translational screening tools for lipedema |
| Yinan Zheng1, John A. Beasley2, Vanessa Crain2, Shannon L. Taylor3, Michael D. Pridmore2, Maria E. Garza2,4, Sheau-Chiann Chen5, Aaron W. Aday6, Joshua A. Beckman6, Paula M.C. Donahue7,8, Manus J. Donahue4,9, and Rachelle L. Crescenzi2,3 | ||
1Vanderbilt University School of Medicine, Nashville, TN, United States, 2Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 3Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 4Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 5Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States, 6Vanderbilt Translational and Clinical Cardiovascular Research Center, Cardiovascular Medicine Division, Vanderbilt University Medical Center, Nashville, TN, United States, 7Department of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, United States, 8Dayani Center for Health and Wellness, Vanderbilt University Medical Center, Nashville, TN, United States, 9Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, United States |
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Keywords: MSK, Screening, Translational Studies Lipedema is an underdiagnosed connective tissue disorder characterized by disproportionate subcutaneous adipose tissue (SAT) accumulation in the lower extremities. Lipedema is frequently misdiagnosed as obesity and objective diagnostic tools are lacking for lipedema. Patients with lipedema (n=22) and BMI-matched controls (n=7) underwent lower extremity MRI and ultrasound evaluations of SAT as potential diagnostic modalities. MRI and ultrasound measurement of SAT thickness yielded good concordance between modalities (Pearson’s r=0.95, reproducibility coefficient=3.3 mm), and demonstrated similar moderate effect sizes (Cohen’s d>0.5) for discriminating lipedema from controls. MRI and ultrasound are promising screening modalities for lipedema. |
| 2767 | Computer 64
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Evaluation of a deep learning-based acceleration technique for ankle MRI protocol in clinical applications |
| Qiang Zhao1, Jiajia Xu1, Yu Xin Yang2, Yuqing Zhao1, Qizheng Wang1, Yongming Dai3, and Huishu Yuan1 | ||
1Peking University Third Hospital, Beijing, China, 2United Imaging Research Institute of Intelligent Imaging, Beijing, China, 3Central Research Institute, United Imaging Healthcare, Shanghai, China |
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Keywords: Joints, Joints, Machine Learning/Artificial Intelligence A deep learning-based compressed sensing (ACS) technology was recently introduced for an integrative MR acceleration solution. This study assessed the effectiveness of using ACS to evaluate ankle injuries. The ACS acceleration technique allows faster imaging than conventional acceleration methods, providing adequate image quality and diagnosis performance. |
| 2768 | Computer 65
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Sodium 23Na-MRI reveals elevated sodium content in lower-extremity skin and adipose tissue in peripheral arterial disease |
| Michael Pridmore1,2, Emily Shardelow3, Shannon L. Taylor1,2,4, Adam Behroozian5, Manus J. Donahue6,7, Alex Sullivan3, Joshua A. Beckman8, and Rachelle Crescenzi1,2,4 | ||
1Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 2Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 3Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, United States, 4Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 5Cardiovascular Medicine, Scripps Memorial Hospital La Jolla, San Diego, CA, United States, 6Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 7Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 8Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States |
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Keywords: MSK, Atherosclerosis, Multi-Nuclear, Peripheral Disease Peripheral artery disease (PAD) is an atherosclerotic occlusive disease that reduces lower-limb perfusion, causes ambulatory dysfunction, and leg pain. Sodium imaging (23Na-MRI) may reveal areas of increased tissue sodium deposition related to the mechanisms of PAD dysfunction. We found that patients with PAD showed increased tissue sodium content in skin, subcutaneous adipose tissue (SAT), and inter-muscular adipose tissue (IMAT) compared to controls. Participants with PAD had lower SAT volume and fat content, arguing against a positive relationship between fat as the mediator of increased tissue sodium. 23Na-MRI may inform PAD mechanisms and is being investigated in response to PAD therapies. |
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| 2771 | Computer 66
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Clinical feasibility of synthetic T1-weighted images in evaluation of rotator cuff injury using ZTE-MRI as reference |
| Jingyu Jiang1, Weiyin Vivian Liu2, Wen Chen3, Ling Sang3, Huizheng Wang3, Xingyao Yu1, and Lin Xu3 | ||
1Biomedical Engineering College, Hubei University of Medicine, Shiyan Hubei, China, 2GE Healthcare,, Beijing, China, 3Taihe Hospital, Hubei University of Medicine,, Shiyan Hubei, China |
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Keywords: Tendon/Ligament, Aging, synthetic Magnetic resonance imaging is the gold standard for evaluation of rotator cuff injury in non-invasive examination. And 90% occur in supraspinatus tendons. In this study, synthetic MRI (SyMRI) generated both structural and functional images to qualitatively and quantitatively evaluate supraspinatus tendon injury using zero-echo magnetic resonance imaging (ZTE-MRI) as structural reference images. Despite superior quality and inter-reader agreement on critical shoulder angle measurements of ZTE-MRI to SyMRI-generated T1WI, SyMRI showed excellent intra-modality agreement of acromion index and CSA to ZTE-MRI and also provided quantitative information for better identifying injured sites at the early stage of rotator cuff injury. |
| 2772 | Computer 67
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Alteration in microcirculation with osteonecrosis of the femoral head: Study on Dynamic Contrast-enhanced MRI |
| Huan Da Wei1, Yuan Zhao Feng1, Dou Wei Qiang2, Wen Qing Qing2, Liu Shao Wei1, Lu Chao1, Zhang Chao1, Xia Tian Wei1, and Shen Ji Rong1 | ||
1Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Nanjing, China, 2MR Research China, GE Healthcare, Beijing, China |
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Keywords: Joints, DSC & DCE Perfusion Osteonecrosis of femoral head (ONFH) occurs due to a defect in the blood supply to the femoral head. In this study, Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) was applied to ONFH patients in different stages to explore the perfusion changes in the progression of the severity of ONFH. It was found that perfusion in the necrotic area was persistently reduced, while in the repair reaction areas, perfusion was progressively enhanced. DCE-MRI can sensitively detect the perfusion changes of ONFH and potentially could predict ONFH development. |
| 2773 | Computer 68
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Longitudinal Changes in Patella Bone Shape in Subjects after ACL Reconstruction |
| James R Peters1, Sibaji Gaj1, Nancy Obuchowski1, Carl Winalski1, Naveen Subhas1, Valentina Pedoia2, Sharmila Majumdar2, Hollis Potter3, Matthew F Koff3, Kimberly K Amrami4, Cale Jacobs5, and Xiaojuan Li1 | ||
1Cleveland Clinic, Cleveland, OH, United States, 2University of California, San Francisco, San Francisco, CA, United States, 3Hospital for Special Surgery, New York, NY, United States, 4Mayo Clinic, Rochester, MN, United States, 5University of Kentucky, Lexington, KY, United States |
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Keywords: Osteoarthritis, Joints Acute knee joint injury often leads to the development of post-traumatic osteoarthritis (PTOA); however, the factors which may indicate PTOA progression are not well understood. Bone shape changes have been suggested as potential predictors for OA development. This study investigates longitudinal changes in patella bone shape in subjects who underwent ACL reconstruction. Subject’s patellae were segmented using machine learning methods and a statistical shape model was used to quantify patella bone shape. Data analysis showed longitudinal changes in patella shape between contralateral and ipsilateral sides, between subjects with allografts and autografts, and associations with age, sex, and BMI. |
| 2774 | Computer 69
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Initial evaluation of PETRA UTE imaging at 7T in a phantom and musculoskeletal tissue specimen |
| Carly Lockard1,2, Bruce Damon1,2, and Hacene Serrai 1,2 | ||
1Stephens Family Clinical Research Institute, Carle Clinical Imaging Research Program, Carle Health, Urbana, IL, United States, 2Carle Illinois Advanced Imaging Center, Urbana, IL, United States |
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Keywords: MSK, High-Field MRI, zero echo time; ultrashort echo time; UTE; ZTE Ultrashort echo-time MRI allow signal acquisition from tissues with ultrashort (<1 ms) T2*. We evaluated repeatability, SNR, acquisition time, and potential for T2* mapping using a modified PETRA sequence at 7T. Signal values were repeatable, and subtraction imaging was both feasible and consistent with those previously reported. T2* mapping had lower repeatability and may require improved modeling of TE-dependent k-space filling strategy effects. Short- and long-TE PETRA imaging was feasible at 7T in a phantom and ex vivo specimen. These initial results will serve as guidance for further optimization/potential applications. |
| 2775 | Computer 70
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A Comparison of High-Resolution Simultaneous Multi-Slice Accelerated Turbo Spin-Echo Knee Imaging with Routine Turbo Spin-Echo Imaging |
| Yanping Xue1, Li Wang1, Hua Gu1, Jiyang Zhang1, Chen Zhang2, Xiuqin Jia1, and Qi Yang1 | ||
1Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China, 2MR Scientific Marketing, Siemens Healthineers, Beijing, China |
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Keywords: MSK, Joints MRI has been widely used in the early detection of osteoarthritis (OA), especially in knee, as an important technique. However, the long acquisition time of MRI is a barrier in improving the quality of imaging and the comfort of patients, especially for pediatric and disabled people. Many imaging acceleration factors have been implied in order to improve the condition. This study focuses on the clinical application of simultaneous multi-slice (SMS) imaging, a newly developed acceleration technique using multi-band RF pulses, which can simultaneously excite, acquire, and reconstruct multiple slices and readout with two-dimensional images. |
| 2776 | Computer 71
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Regional Achilles Tendon Segmentation for Quantitative Magnetic Resonance Imaging at 1.5 Tesla |
| Dominik Vilimek1, Radana Kahankova1, Radek Martinek1, Martin Kryl1, Veronika Janacova2, Milos Golian3,4, Jaroslav Uchytil3, Pavla Hanzlikova5,6, Pavol Szomolanyi2,7, Siegfried Trattnig2,8,9,10, and Vladimir Juras2 | ||
1Department of Cybernetics and Biomedical Engineering, VSB Technical University of Ostrava, Ostrava, Czech Republic, 2Department of Biomedical Imaging and Image-guided Therapy, High Field MR Centre, Medical University of Vienna, Vienna, Austria, 3Department of Human Movement Studies, Human Motion Diagnostic Center, University of Ostrava, Ostrava, Czech Republic, 4Department of Radiology, Vitkovice Hospital, Ostrava, Czech Republic, 5Department of Imaging Methods, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic, 6Department of Radiology, University Hospital Ostrava, Ostrava, Czech Republic, 7Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, 8CD Laboratory fo MR Imaging Biomarkers (BIOMAK), Vienna, Austria, 9Austrian Cluster for Tissue Regeneration, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria, 10Institute for Clinical Molecular MRI in the Musculoskeletal System, Karl Landsteiner Society, Vienna, Austria |
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Keywords: Tendon/Ligament, Machine Learning/Artificial Intelligence Changes in the Achilles tendon composition are associated with an increased risk of tendinopathy which is common in middle-aged overweight patients and is one of the most common sports injuries. However, measuring and quantifying such properties is a challenging task. The purpose of this paper is to introduce an end-to-end pipeline for segmenting Achilles tendon using deep convolutional neural networks and automatic segmentation into three segments. Our model shows promising results outperforming state-of-the-art approaches (Dice 90.6% and Jaccard 84.0%). This is one of the key steps for short and long T2* value analysis from 1.5T data. |
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Fast dual-echo ultrashort echo time (UTE) MRI to estimate long T2 fraction in tendons and detect age-and osteoporosis-related differences |
| Saeed Jerban1,2,3, Amir Masoud Afsahi 1, Sophia Dwek1, Jiyo Athertya1, Bhavsimran Malhi1, Dina Moazamian1, Yajun Ma1,2, Sam Sedaghat1, Hyungseok Jang1,2, Gina Woods4, Christine B Chung1,2, Jiang Du1,2, and Eric Y Chang1,2 | ||
1Department of Radiology, University of California, San Diego, La Jolla, CA, USA, San Diego, CA, United States, 2Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, La Jolla, CA, USA, San Diego, CA, United States, 3Department of Orthopedic Surgery, University of California, San Diego, La Jolla, CA, USA, San Diego, CA, United States, 4Department of Medicine, University of California, San Diego, La Jolla, CA, USA, San Diego, CA, United States |
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Keywords: Tendon/Ligament, Tendon/Ligament Tendon and bone comprise a special interacting unit. Bone loss in osteoporosis (OPo) may associate with a reduction in tendon quality that needs to be investigated. We investigated the tendon quality differences between OPo patients, osteopenia (OPe) patients, and healthy volunteers with normal bone (Normal) using the Frac-LongT2 index, a rapid measure performed by dual-echo ultrashort echo time (UTE) MRI. The estimated Frac-LongT2 in the anterior and posterior tibialis tendon (ATT and PTT) were significantly higher in the OPo group compared with the Normal group. This study highlights the potential of this rapid UTE-based technique for in vivo tendon assessment. |
| 2778 | Computer 73
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Quantification of soft tissue of the buttocks in a seated position |
| Jill M Slade1, Nkhensani Mogale2, Daniel Schanz1, Viktor Ilyasov1, Justin Scott3, Albert van Schoor2, and Tamara R Bush3 | ||
1Radiology, Michigan State University, East Lansing, MI, United States, 2University of Pretoria, Pretoria, South Africa, 3Mechanical Engineering, Michigan State Univerisity, East Lansing, MI, United States |
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Keywords: MSK, Muscle MRI is well suited to quantify soft tissue but challenges remain in using MRI to address soft tissue in a seated position and for studying how tissue responds to loading. IDEAL and T1 weighted images were used to quantify apparent fat fraction and soft tissue thicknesses of the buttocks in a side lying position with the tissue unloaded and loaded. Tissue compression during loading predominantly reflected changes in the muscle and tendon. Intramuscular fat was not related to the change in muscle/tendon. These methods may be useful to study soft tissue in populations at risk for pressure ulcer development. |
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Diffusion Tensor Imaging of tendon and ligament: Influence of crimping behavior and microstructural variations. |
| Noel Naughton1, Amir Ostadi Moghaddam1, Mariana Kersh1,2,3, Samni Koyejo4, Shreyan Majumdar1, Amy Wagoner Johnson1,2,3,5, and Bruce Damon1,6 | ||
1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Biomedical and Translational Sciences, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Computer Science Department, Stanford University, Palo Alto, CA, United States, 5Carle R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 6Carle Clinical Imaging Research Program, Stephens Family Clinical Research Institute, Carle Health, Urbana, IL, United States |
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Keywords: Tendon/Ligament, Diffusion Tensor Imaging To guide development and optimization of dMRI protocols, here we present a numerical simulation framework for analyzing how changes in collagen microstructure influence the measured diffusion tensor. We experimentally characterize a porcine digital flexor tendon using second harmonic generation (SHG) microscopy to identify characteristic geometric parameters and use these parameter ranges to perform a sensitivity analysis of what microstructural features most influence diffusion tensor imaging (DTI) metrics. We conclude by exploring how geometric changes in collagen crimping due to tissue strain influence DTI metrics. |
| 2780 | Computer 75
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Feasibility study of synthetic MRI in shoulder imaging |
| Ni Yabo1, Tian Zhaorong1, and Wang zhijun1 | ||
1Ningxia Medical University General Hospital Radiology department, Yinchuan, China |
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Keywords: Multimodal, Tendon/Ligament In this work,we found that the image quality of shoulder synthetic MRI sequence is not comparable to that of conventional image quality, and the scanning time is long, but once scanning can generate multiple sets of quantitative images, T2 mapping of synthetic sequence can provide a new quantitative method for the diagnosis and differential diagnosis of supraspinatus tendon related diseases. |
| 2781 | Computer 76
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A preliminary analysis for vertebral marrow fat and disc herniation or annular tear by simultaneous multi-relaxation-time Imaging (TXI) method |
| Limei Han1,2, Jie Yang1, Zhiqiang Ming1, Hao Feng1, Yantao Huang1, Hengping Wu1, Chao Yuan1, Huan Guo1, Meining Chen3, and Jianquan Zhong1 | ||
1Department of Radiology, Zigong First People's Hospital, Zigong, China, 2North Sichuan Medical College, Nanchong, China, 3MR Scientific Marketing, SIEMENS Healthineers Ltd., Shanghai, China |
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Keywords: Screening, Degenerative, lumbar disc herniation, annular tear, bone marrow fat Recently T1 mapping, T2* mapping and bone marrow fat fraction (BMFF) has been separately applied to spine. But it hasn't studied the value of those mappings together with intervertebral discs (IVD) degeneration. In this study, we obtained three values (T1, T2* and BMFF value) by simultaneous multi-relaxation-time imaging technique, called TXI. We found that T1 values in abnormal (herniation or annular tear) disc were significantly lower than those in the normal. This study demonstrates that T1 mapping can be helpful in detecting IVD with herniation or annular tear. |
| 2782 | Computer 77
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Repeatability of Cones UTE-T2* Mapping of Cartilage |
| Ashley A. Williams1, Gordhan B. Mahtani1, Jade R He1, Adam L. C. Wadsworth1, and Constance R. Chu1 | ||
1Orthopaedic Surgery, Stanford University, Stanford, CA, United States |
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Keywords: Cartilage, Relaxometry, Repeatability, UTE-T2* This work examines the combined acquisition and segmentation repeatability of Cones UTE-T2* measures in tread mark cartilage regions and in small 2-D cartilage and meniscus ROIs in the knees of uninjured participants. Both intra- and inter-day repeatability assessments showed excellent average CVs of less than 10% in all tread mark ROIs and in all but 2 small 2-D ROIs segmented from only a single slice. ICC estimates were good to excellent (0.79–0.98) in all tread mark ROIs and ranged from moderate to excellent (0.54-0.98) in small 2-D ROIs corresponding to absolute precision errors of less than 1ms in most cases. |
| 2783 | Computer 78
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Rapid high-resolution musculoskeletal MR imaging with a super resolution deep learning constrained Compressed SENSE reconstruction |
| Zheng Sun1, Shan Huang2, Xiance Zhao2, Weibo Chen2, Queenie Chan3, Yajing Zhang4, Johannes M. Peeters5, and Yuehua Li1 | ||
1Shanghai Sixth People's Hospital, Shanghai, China, 2Philips Healthcare, Shanghai, China, 3Philips Healthcare, Hong Kong, China, 4Philips Health Technology, Suzhou, China, 5Philips Healthcare, Best, Netherlands |
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Keywords: Skeletal, Bone The integration of compressed-SENSE and artificial intelligence allows to acquire high-resolution images within relatively short scan times The purpose of this study is to compare the image quality of the musculoskeletal images reconstructed with Compressed -SENSE (CS), CS with integrated artificial intelligence (CS-AI) and CS-AI combined with superresolution(CS-AI-HR) . We found that the image quality was significantly improved by using CS-AI-HR compared to CS. This study provides supportive information for the application of CS-AI-HR in routine clinical practice. |
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Increase in Fast-relaxing Sodium After a Brief Plantarflexion Exercise Detected by Multi-Echo UTE MRI and Biexponential Regression |
| Kwan-Jin Jung1, Hsin-Yu Fang2, Brad Sutton3, and Kenneth Wilund2 | ||
1Biomedical Imaging Center, Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States |
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Keywords: Muscle, Relaxometry, Sodium, Muscle, Exercise We measured the exercise-induced change in fast and slow T2-relaxing sodium in calf muscles separately using a UTE sequence with multiple echoes. Three minutes of plantarflexion exercise resulted in an increase in the fast-relaxing sodium and no change in the slow-relaxing component. Based on the known physiology that muscle intracellular sodium increases during muscle contraction, the measured fast-relaxing sodium might represent muscle intracellular sodium. This finding is valuable in studying intra- and extracellular sodium separately. |
| 4052 | Computer 122
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Investigating muscle micro-trauma with time-dependent diffusion and the random permeable barrier model |
| Susanne S. Rauh1, Donnie Cameron2, Oliver J. Gurney-Champion3, Mario Maas3, Martijn Froeling4, Hermien E. Kan2, Aart Nederveen3, Gustav Strijkers1, and Melissa T. Hooijmans3 | ||
1Department of Biomedical Engineering and Physics, Amsterdam Movement Sciences, Amsterdam UMC, location AMC, Amsterdam, Netherlands, 2C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 3Department of Radiology and Nuclear Medicine, Amsterdam UMC, location AMC, Amsterdam, Netherlands, 4Department of Radiology, Utrecht UMC, Utrecht, Netherlands |
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Keywords: Muscle, Diffusion Tensor Imaging Repetitive muscle micro-trauma can result in severe muscle injuries. Diffusion tensor imaging can detect small but significant changes due to muscle micro-trauma, but the sensitivity is limited. Longer and multiple diffusion times can potentially increase the sensitivity to micro-trauma as they facilitate muscle fiber diameter and permeability estimations with the random permeable barrier model (RPBM). In this study, we demonstrated that a diffusion time of 116.7ms showed largest percentage change in DTI indices suggesting an increased sensitivity to exercise-induced muscle micro-trauma after running a marathon. No effect was found in the RPBM-derived membrane permeability and fiber diameter. |
| 4053 | Computer 123
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Axial diffusivity and kurtosis derived based on DWI reflect microstructure changes in patients with in stress urinary incontinence patients |
| Kun Ou1, Weiyn Vivian Liu2, and Kun Zhang1,3 | ||
1Department of Radiology, First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, China, 2MR Research, GE Healthcare, Beijing, China, 3College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, ChangSha, China |
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Keywords: Muscle, Diffusion/other diffusion imaging techniques, Diffusion kurtosis imaging Stress urinary incontinence (SUI) is the most common form of urinary incontinence. However, in patients with SUI, the pelvic floor muscles generally have no obvious radiographic abnormalities. This study applied diffusion-weighted imaging with different analysis models and found that patients with SUI had significantly lower FA and Da values based on gaussian-distributed water movement and higher values in the Ka based on non-gaussian-distributed water movement compared to the healthy volunteers. This study showed both DTI and DKI derived parameters can detect microstructure changes in the the pubic visceral muscle of the SUI patients. |
| 4054 | Computer 124
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In Vivo Mapping of Muscle Fibrosis: The Influence of Signal Model Inputs |
| Mary Elizabeth Hall1, Yael Vainberg1, Garry Gold1, and Valentina Mazzoli1 | ||
1Radiology, Stanford University, Stanford, CA, United States |
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Keywords: Muscle, Aging, Fibrosis, Sarcopenia Fibrosis could be an early sign of declining muscle quality. Short T2*-signal fraction, which can be calculated by fitting a 3-exponential model to UTE data, has been shown to be correlated with collagen content, which is related to fibrosis. However, this type of signal model has 8 fitting parameters, which could result in overfitting to a limited number of echoes. We constrained the signal model 3 different ways, and compared the resulting short T2*-signal fraction values. There were significant differences between methods, demonstrating that these choices can affect parameter values and diagnostic sensitivity of short T2*-signal fraction for fibrosis detection. |
| 4055 | Computer 125
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Intervertebral disc’s quantitative measurements from synthetic MR correlates with its degeneration and bone marrow fat fraction |
| Xiaochun Yuan1, Ze Li1, Min Fu1, Xiaochen Wei2, and Junrong Chen3 | ||
1Chengdu Sport University, Chengdu, China, 2GE Healthcare China, Beijing, China, 3Sichuan Province Orthopedic Hospital, Chengdu, China |
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Keywords: Muscle, Fat, Quantitative imaging, Lumbar disc herniation The conventional Pfirrmann grading currently used to assess the degree of disc degeneration is a semi-quantitative assessment criterion. And the relationship between vertebral body bone marrow fat and disc degeneration needs further clarification. In this study, quantitative synthetic MR technique as well as fat quantification MR technique are used to investigate relationship between imaging markers and degeneration levels. Results indicates intervertebral discs’ quantitative T2, T1 and PD values are significantly different among Pfirrmann grading groups. Significant negative correlations are found between Pfirrmann grading and quantitative values. T1 and PD values have weak correlation with bone marrow fat fraction. |
| 4056 | Computer 126
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Relationship between the properties of paraspinal muscles and bone mineral density in patients with lumbar disc herniation |
| Ze Li1, Min Fu1, Xiaochun Yuan1, Huilou Liang2, and Junrong Chen3 | ||
1Chengdu Sport University, Chengdu, China, 2GE Healthcare China, Beijing, China, 3Sichuan Province Orthopedic Hospital, Chengdu, China |
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Keywords: Muscle, Fat, Quantitative imaging, Paraspinal muscle Paraspinal muscles and vertebral bodies are important to maintain spinal stability. Muscles and bones are functional tissues that interact with each other. We investigated the relationship between the properties of paraspinal muscles obtained from MR imaging and bone mineral density of vertebral bodies measured from quantitative CT in patients with lumbar disc herniation (LDH). Our results showed that the fat fraction of paraspinal muscles was negatively correlated with bone mineral density of vertebral bodies in LDH patients, and the fat fraction of multifidus muscle at the L3/L4 lumbar disc level may be the optimal predictor of bone mineral density changes. |
| 4057 | Computer 127
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Time-dependent diffusion in healthy adult human thigh muscle in a clinically feasible acquisition |
| Amy McDowell1, Thorsten Feiweier2, Carolynne Doherty1, Stephen J Wastling1, Matt G Hall3, Chris A Clark4, Tarek Yousry5, Mary Reilly1, and John S Thornton1 | ||
1Queen Square Centre for Neuromuscular Diseases, University College London, London, United Kingdom, 22Siemens Healthcare GmbH, Erlangen, Germany, 3Medical Radiation Physics, National Physical Laboratory, London, United Kingdom, 4Developmental Imaging and Biophysics, University College London, London, United Kingdom, 5Queen Square Institute of Neurology, University College London, London, United Kingdom |
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Keywords: Muscle, Diffusion Tensor Imaging Muscle fibres are larger than axons with a complex hierarchical internal structure causing a decrease in the diffusion coefficient with diffusion time. Acquisition of larger field-of-view thigh-level images is challenged by increased distortion, higher B0 inhomogeneity, incomplete fat saturation and longer acquisition times. We optimised a protocol to study the time-dependence of diffusion indices in healthy human thigh muscle in a clinically feasible scan time. MD and FA showed strong time dependence but slight disparities from previous work in the calf, possibly due to differences in the musculature of the thigh, male/female ratio, or changes in the acquisition with optimisation. |
| 4058 | Computer 128
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Association Between Modic Change and Paraspinal Muscle Fat Infiltration Based on MRI |
| Min Fu1, Ze Li1, Xiaochun Yuan1, Xiaocheng Wei2, and Junrong Chen3 | ||
1Chengdu Sport University, Chengdu, Sichuan, China, 2GE Healthcare China, Beijing, China, 3Sichuan Province Orthopedic Hospital, Chengdu, Sichuan, China |
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Keywords: Muscle, Fat, Quantitative imaging, Modic change Paraspinal muscles play an important role in maintaining the stability of lumbar spine. The influencing factors of paraspinal muscle degeneration are still controversial. IDEAL-IQ MR sequence can provide quantitative fat fraction map to objectively and accurately evaluate the fat infiltration in paraspinal muscles. By using IDEAL-IQ MR sequence, this study investigated the influence of Modic change (MC) on quantitative propertied of paraspinal muscles in patients with low back pain (LBP). Our results showed that MC can aggravate the degeneration of paraspinal muscles, especially the multifidus, in LBP patients. |
| 4059 | Computer 129
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Evaluation of viscoelastic changes of the psoas major muscle after exercise using MR elastography |
| Tetsushi Habe1,2, Tomokazu Numano1,3, Daiki Ito1,2, Kouichi Takamoto4, and Hisao Nishijo5 | ||
1Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, 2Office of Radiation Technology, Keio University Hospital, Tokyo, Japan, 3Human Technology Research Insutitue, National Institute of Advanced Industrial Science and Techonology, Ibaraki, Japan, 4Department of Sport and Health Sciences, Faculty of Human Sciences, University of East Asia, Yamaguchi, Japan, 5System Emotional Science, Faculty of Medicine, University of Toyama, Toyama, Japan |
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Keywords: Muscle, Elastography The shear modulus of the psoas major muscle (PM) after exercise has been evaluated using magnetic resonance elastography (MRE) previously, however, a separate evaluation of elasticity and viscosity has not been performed. We evaluate storage modulus representing elasticity and loss modulus representing viscosity of the PM using MRE after exercise in this study. Comparing the before and immediately after exercise, the loss modulus showed a greater rate of decrease than the storage modulus, suggesting that the loss modulus, which reflects viscosity, is more useful for detecting changes of muscle tissue immediately after exercise. |
| 4060 | Computer 130
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Imaging of the Contraction Pattern of Spontaneous Muscular Activities using a Multiple-Point Diffusion-Weighted Stimulated Echo Sequence |
| Martin Schwartz1,2, Petros Martirosian1, Guenter Steidle1, Bin Yang2, and Fritz Schick1 | ||
1Section on Experimental Radiology, University Hospital of Tuebingen, Tuebingen, Germany, 2Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany |
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Keywords: Muscle, Muscle Spontaneous mechanical activities in resting musculature can be visualized using stimulated-echo or spin-echo diffusion-weighted sequences. Temporal resolution is limited to the sampling of one point in time of the contraction pattern. Therefore, a concept for multiple points in time imaging of spontaneous activities is proposed in this work. The implemented MR sequence was validated by measurements from a water phantom and of the resting lower leg musculature of healthy subjects. |
| 4061 | Computer 131
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Feasibility of Automated Segmentation of 3D Shoulder Muscle Volume via Deep Learning for Rotator Cuff Repair Patients |
| Mingrui Yang1, Bong-Jae Jun1, Tammy Owings1, Joshua Polster1, Carl Winalski1, Kathleen Derwin1, Eric Ricchetti1, and Xiaojuan Li1 | ||
1Cleveland Clinic, Cleveland, OH, United States |
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Keywords: Muscle, Machine Learning/Artificial Intelligence It has been shown that muscle volume and fat fraction play significant roles in musculoskeletal disorder diagnosis and prognosis. Reliable clinical tools for their evaluation, however, are currently missing. One hurdle is the challenging and laborious manual segmentation process on MR images. We proposed here a deep learning based automated tool for 3D shoulder muscle volume segmentation and achieved accurate segmentation results on clinical MR images from rotator cuff repair patients. The proposed model can be a valuable tool for shoulder muscle volume quantification and subsequent fat fraction analysis to further understand their association with clinical outcomes following shoulder procedures. |
| 4062 | Computer 132
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Towards patient-friendly arterial-spin-labeling MRI in muscle: Effect of exercise intensity and standardisation on perfusion parameters |
| Donnie Cameron1, Esther J. Schrama2, Linde Boogaarts1, Thom T.J. Veeger1, Celine Baligand3, Lydiane Hirschler1, Matthias J.P. van Osch1, and Hermien E. Kan1 | ||
1C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Neurology, Leiden University Medical Center, Leiden, Netherlands, 3Laboratoire des Maladies Neurodégénératives, Université Paris-Saclay, Fontenay-aux-Roses, France |
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Keywords: Muscle, Perfusion, Exercise Perfusion is fundamental to muscle function, and is limited in muscular dystrophies—representing a promising biomarker for clinical trials. However, in-magnet exercise paradigms for measuring ASL perfusion are seldom standardised and require high-intensity exercise, which is impracticable in patients. In volunteers, we tested the acceptability of three protocols: two standardised paradigms with different intensities, and a non-standardised paradigm at a single intensity. Exercise standardisation improved SNR. In general, muscle blood flow, T2*, and SNR decreased, while arterial transit time increased with time after exercise; T2* was higher after high-intensity exercise. SNR at lower exercise-intensity was insufficient for robust perfusion-parameter estimation. |
| 4063 | Computer 133
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The effects of exercise on ankle mobility and lower leg hyaluronan distribution in type 2 diabetes |
| Rajiv G Menon1, Smita Rao2, Preeti Raghavan3, and Ravinder Regatte1 | ||
1Radiology, NYU Grossman School of Medicine, New York, NY, United States, 2Department of Physical Therapy, New York University, New York, NY, United States, 3Johns Hopkins University School of Medicine, Baltimore, MD, United States |
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Keywords: Muscle, Diabetes, exercise intervention Type 2 Diabetes Mellitus (T2DM) is a major cause of a number of systemic pathological processes, including muscle stiffness. In this study, we examine the effects of exercise on peak ankle dorsiflexion, and ankle stiffness and investigate hyaluronan distribution with 3D-T1ρ MRI in 10 individuals with T2DM. Our findings suggest that participation in a 10-week moderate intensity exercise intervention may alter hyaluronan distribution in the compartments of the lower leg calf muscle, and is accompanied by increased dorsiflexion, reduced stiffness in individuals with diabetes, and a reduction in MRI based T1ρ measures |
| 4064 | Computer 134
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Variational Model Augmented Deep Learning for Small Training Data MRI Thigh Muscle Segmentation |
| Paramjyoti Mohapatra1, Weihong Guo1, Mingrui Yang2, Richard Lartey2, and Xiaojuan Li2 | ||
1Mathematics, Applied Mathematics and Statistics, Case Western Reserve University, Cleveland, OH, United States, 2Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States |
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Keywords: Muscle, Machine Learning/Artificial Intelligence, muscle segmentation, fusion, variational model Accurate automatic MRI thigh muscle group segmentation is essential for muscle morphology and composition which are related to osteoarthritis and sarcopenia. Due to challenges caused by lack of contrast between muscle groups, Deep Learning (DL) becomes a more natural choice than traditional model based approaches. It is however expensive to obtain a large amount of training data and DL using small training data often results in overfitting. We use a variational model based segmentation method in conjunction with a Bayesian neural network to optimize the train framework, producing about 1.6% increase in dice coefficients while working with minimal annotated data. |
| 4065 | Computer 135
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Large coverage, high temporal and spatial resolution lower extremity blood oxygen level-dependent imaging |
| Jianxun Qu1, Xiaoyuan Fan2, Tianye Lin3, Xiaoxi Yu4, and Feng Feng2 | ||
1SIEMENS Healthineers, Beijing, China, 2Radiology Department, Peking Union Medical College Hospital, Beijing, China, 3Radiology Department, Peking University Cancer Hospital & Institute, Beijing, China, 4Vascular Surgery Department, Peking Union Medical College Hospital, Beijing, China |
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Keywords: Muscle, Perfusion Multi echo gradient echo (GRE) sequence is usually used in lower extremity BOLD experiments. This study replaced the GRE acquisition by SMS EPI and achieved broader coverage and higher temporal and spatial resolution. The minimum ischemia value (MIV) during the ischemia session and the R2* change rate (Grad) during the reperfusion session were calculated. Both MIV and Grad present muscle group-wise distribution. This study demonstrated the feasibility of the SMS GRE-EPI sampling strategy in the skeletal muscle BOLD experiment. |
| 4066 | Computer 136
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lower limbs skeletal muscle perfusion evaluation with the Fourier decomposition technique |
| Jianxun Qu1 and Tianye Lin2 | ||
1SIEMENS Healthineers, Beijing, China, 2Radiology Department, Peking University Cancer Hospital & Institute, Beijing, China |
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Keywords: Muscle, Perfusion This study incorporated the Fourier decomposition (FD) technique to the lower extremity blood oxygen level-dependent, or reactive hyperemia, technique to evaluate the perfusion level of lower limbs. A periodically repeated ischemia-reperfusion paradigm was used to support the frequency analysis in FD. A characteristic frequency intensity corresponding to the ischemia-reperfusion cycle frequency was observed. The feasibility of the proposed method was demonstrated on healthy subjects. |
| 4067 | Computer 137
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Quiet Lumbar Spine MR Imaging: Preliminary Study with Different Noise Reduction Factors |
| Jiageng Shen1, Ailian Liu1, Qingwei Song1, Shuheng Zhang2, and Guobin Li2 | ||
1the First Affiliated Hospital of Dalian Medical University, Dalian, China, 2Shanghai United Imaging Healthcare Co., Ltd, Shanghai, China |
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Keywords: Muscle, Spinal Cord To evaluate the clinical value of quiet T1WI and T2WI sequences in lumbar spine imaging with different noise reduction factors (RFs). |
| 4068 | Computer 138
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Monitoring changes of the muscles around the knee joint in amateur marathon athletes using synthetic MRI: a preliminary study |
| Dantian Zhu1, Wenhao Wu1, Shaolin Li1, Long Qian2, Yajun Ma3, and Yijie Fang1 | ||
1Department of Radiology,Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, China, 2MR Research, GE Healthcare, Beijing, China, 3University of California, San Diego, Department of Radiology, San Diego, CA, United States |
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Keywords: Muscle, Muscle To investigate the value of synthetic MRI sequences for quantitative detection of the muscles around the knee joints before and after a marathon. Marathon runners were examined with Synthetic MRI sequences of both knees. Quantitative profiles of T1, T2, and PD were obtained after scanning. The differences in T1, T2, and PD values of each muscle were analyzed. Most muscle subregions had elevated T1, T2, and PD values 48 hours after the marathon compared to pre-race, and decreased after 1 month of post-race rest. The synthetic MRI sequences can be useful for detecting dynamic changes in the knee muscles. |
| 4069 | Computer 139
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Automatic Segmentation of Rotator Cuff Muscles on MR Images Using Deep Learning |
| Ehsan Alipour1, Majid Chalian1, and Hesamoddin Jahanian1 | ||
1Radiology, University of Washington, Seattle, WA, United States |
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Keywords: Muscle, MSK, Deep learning Rotator cuff (RC) injuries are a common occurrence affecting millions of people across the globe. Quantitative MRI-based evaluation of RC injuries can aid in early diagnosis and improve the treatment outcome. A crucial step towards developing a quantitative, clinically relevant methods for these patients, is developing reliable automatic techniques for segmentation of RC muscles. In this study, we developed a deep convolutional neural network model to automatically segment RC muscles on T1-weighted MR images. We showed that the proposed deep learning method provides rapid and reliable automatic segmentation of RC muscles, with an accuracy comparable with that of human raters. |
| 4070 | Computer 140
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The Feasibility Study of Extraocular Muscle Volume in Patients with Myasthenia Gravis Based on 3D TOFMRA |
| Qin Zhou1, Pei Chen1, Zhiyun Yang1, Xiaoxiao Zhao2, Yingxi Chen1, and Mengzhu Wang3 | ||
1The first affiliated hospital of sun yat-sen university, Guangzhou, China, 2The first affiliated hospital of sun yat-sen university, Guanzhou, China, 3MR Scientific Marketing, Siemens Healthineers Ltd, Guanzhou, China |
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Keywords: Muscle, MR Value, myasthenia gravis, TOF MRA, extraocular muscle The study investigated the feasibility of TOF MAR sequence in evaluating extraocular muscle morphological changes in patients with myasthenia gravis. The results show that volume measurement of EOM based on TOF MRA imaging can effectively quantify atrophy of EOM in MG patients, which is significantly related to the poor response to medication and the long duration of the disease, meaning that it can be used as a non-invasive auxiliary diagnostic tool for prognosis evaluation of MG patients. |
| 4206 | Computer 121
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Q-Dixon MRI and High-Speed T2-Corrected Multiecho MR Spectroscopy to Quantify Thigh Muscle Fat Content in Dialysis Patients |
| Wenshuang Zhang1, Ling Wang1, Dong Yan1, Yanglei Wu2, Yi Yuan1, and Xiaoguang Cheng1 | ||
1Department of Radiology, Peking University Fourth School of Clinical Medicine, Beijing Jishuitan Hospital, Beijing, China, 2MR collaborations, Siemens Healthineers Ltd., Beijing, China |
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Keywords: Muscle, Fat This study evaluated the correlation and consistency of proton density fat fraction (PDFF) measured by Q-Dixon magnetic resonance imaging (MRI) and high-speed T2-corrected multiecho (HISTO) magnetic resonance spectroscopy (MRS) for quantifying thigh muscle fat content in patients undergoing dialysis. Q-Dixon MRI exhibited good correlation and consistency with the HISTO MRS for thigh muscle fat quantitative measurements indicating that Q-Dixon MRI may be a reliable alternative to HISTO MRS in clinical assessment and radiological quantitative evaluation of thigh muscle fat infiltration. |
| 4207 | Computer 122
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Elevated Muscle Water T2 in Dystrophinopathy |
| Glenn Walter1, Alison Barnard2, Sean Forbes2, Rebecca Willcocks2, Eric Baetscer3, William Triplett2, William Rooney 3, and Krista Vandenborne2 | ||
1Physiology, University of Florida, Gainesville, FL, United States, 2Physical Therapy, University of Florida, Gainesville, FL, United States, 3Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States |
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Keywords: Muscle, Muscle, muscular dystrophy Both MRI and MRS measures reveal that water T2 can be elevated in individuals living with dystrophin deficits, which includes patients with DMD, BMD and manifesting carriers. This has important implications when evaluating therapeutics aimed at decreasing inflammation (e.g., corticosteroids or NFkb inhibitors) or disease modifying interventions, such as gene therapies. |
| 4208 | Computer 123
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Diffusion Tensor Imaging parameters predict quadriceps strength in younger and older healthy adults |
| Yael Vainberg1, Jessica Asay1, Andrew Schmidt1, Julie Muccini1, Garry Gold1, Feliks Kogan1, and Valentina Mazzoli1 | ||
1Radiology, Stanford University, Stanford, CA, United States |
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Keywords: Muscle, Diffusion Tensor Imaging, Sarcopenia The loss of muscle strength was previously thought to be primarily impacted by the loss of muscle volume due to sarcopenia during aging, however, this did not explain why strength declined more rapidly than muscle volume. To better understand this, our study aimed to explore Diffusion Tensor Imaging parameters and their correlations to muscle strength in addition to volume. As expected, volume had a strong positive correlation with all functional strength tests. However, we also observed that radial diffusivity had a significant negative correlation with eccentric functional strength tests, but no correlation was found with the concentric tests. |
| 4209 | Computer 124
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Assessment of Charcot-Marie-Tooth disease severity using quantitative T2 and fat fraction biomarkers |
| Maria Holodov1, Shimon Shahar2, Tamar Blumenfeld-Katzir1, David Bendahan3, and Noam Ben-Eliezer1,4,5 | ||
1Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, 2Center of AI and Data Science (TAD), Tel Aviv University, Tel Aviv, Israel, 3CNRS, CRMBM, Aix Marseille University, Marseille, France, 4Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, 5Center for Advanced Imaging Innovation and Research (CAI2R), New-York University Langone Medical Center, New York, NY, United States |
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Keywords: Muscle, Muscle, Muscular disorder; Neuropathy; Fat water separation Charcot-Marie-Tooth (CMT) is the most prevalent inherited neurological disease, commonly presenting in the first or second decade of life. Notwithstanding the ongoing advancement of non-invasive imaging, effective and sensitive tools for monitoring CMT and other neuromuscular conditions are lacking. Here we investigated the utility of the extended echo-modulation-curve (EMC) algorithm, for precise mapping of T2 relaxation times and fat fraction (FF) in CMT patients. Results indicate that quantitative T2 and FF biomarkers correlate with clinical scores. These can be useful for precise and objective monitoring of microstructural processes occurring in CMT. |
| 4210 | Computer 125
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Diffusion Tensor Imaging in the Lower Leg of a Preclinical Model of Amyotrophic Lateral Sclerosis |
| Ethan Mathew1, Natenael Semmineh2, Alberto Fuentes1, Deborah Healey2, Richard Dortch1, Bruce Damon3, and Chad Quarles2 | ||
1Barrow Neuroimaging Innovation Center, Barrow Neurological Institute, Phoenix, AZ, United States, 2Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, United States, 3University of Illinois Urbana-Champaign, Urbana, IL, United States |
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Keywords: Muscle, Diffusion Tensor Imaging This study examined changes in diffusion tensor parameters during amyotrophic lateral sclerosis progression using a transgenic rodent model. DTI was performed at four timepoints with an even amount of male and female rats to probe sex differences. Leg muscles were excised following scanning for histological analysis. Sex had a statistically significant effect on all parameters. Mean, radial, and axial diffusivity as well as the second eigenvalue were the most sensitive markers of disease progression. |
| 4211 | Computer 126
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1H-MRS human skeletal muscle quantification: a repeatability analysis |
| Alejandro Amador1,2 and Michael D. Noseworthy1,2,3,4 | ||
1School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada, 2Imaging Research Centre, St. Joseph's Healthcare, Hamilton, ON, Canada, 3Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada, 4Department of Radiology, McMaster University, Hamilton, ON, Canada |
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Keywords: Muscle, Spectroscopy 1H-MRS of skeletal muscle presents challenges due to the highly structured arrangement of muscle fibres and their orientation to B0, complicating metabolite visibility and quantification. This study aimed to assess the repeatability of 1H-MRS in the anterior tibialis muscle in healthy volunteers by acquiring multiple spectra during and within different scanning sessions. A robust method for positioning of the voxel-of-interest was used to ensure reproducible acquisition. Data analysis was done using LCModel. Statistical analysis showed no significant difference in metabolite ratios against water across sessions, suggesting good repeatability of 1H-MRS of skeletal muscle. |
| 4212 | Computer 127
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Quantification of lumbar paraspinal muscle injury in patients with low back pain using intravoxel incoherent motion diffusion weighted imaging |
| Yinqi Liu1, Weiyin Vivian Liu2, and Kun Zhang1,3 | ||
1Department of Radiology, First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, China, 2MR Research, GE Healthcare, Beijing, China, 3College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China |
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Keywords: Muscle, Diffusion/other diffusion imaging techniques Chronic low back pain (CLBP) has been reported to be associated with lumbar paraspinal muscles injury. Lumbar paraspinal muscles injury may result from oxidative stress and inflammation. In our study, D* at the middle of L4 and L5 levels of the paraspinal muscles was significantly higher in LBP group than in HCs. The fluid oozing from the inflammation can lead to greater unrestricted molecular movement. Therefore, non-invasive and contrast-agent-free IVIM could be a good perfusion predictor of lumbar paraspinal muscle injury. |
| 4213 | Computer 128
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Exercise-induced changes of macromolecular content in calf muscles quantified with T1ρ magnetic resonance imaging |
| Yanbin Li1,2, Chang Ni2, Jialin Wang1, Zhenfeng Lv3,4, Xin Mu2, Mingyan Wu1, Haikun Qi3,4, and Jeff L. Zhang2 | ||
1Central Research Institute, Shanghai United Imaging Healthcare Co., Ltd, Shanghai, China, 2Vascular and Physiologic Imaging Research (VPIR) Lab, School of Biomedical Engineering, ShanghaiTech University, Shanghai, China, 3School of Biomedical Engineering, ShanghaiTech University, Shanghai, China, 4Shanghai Clinical Research and Trial Center, Shanghai, China |
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Keywords: Muscle, Quantitative Imaging Exercise could induce changes in skeletal muscle’s macromolecular content. In this study, we used an exercise-then-imaging protocol to verify and characterize such phenomenon for calf muscles of healthy subject. A T1ρ mapping technique was used for imaging calf muscles before and after planter flexion of different loads. It was found that post-exercise increases in T1ρ values of gastrocnemius and peroneus longus at exercise load of 16 and of 20 lbs were significantly higher than that of 8 lbs. In conclusion, T1ρ is sensitive to changes of macromolecular content in calf muscles induced by plantar flexion of moderate or high intensity. |
| 4214 | Computer 129
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A multiparametric protocol to investigate the effects of physical activity on lumbar spine muscles |
| Marta B. Maggioni1, Renat Sibgatulin1, Martin Krämer1,2, Daniel Güllmar1, and Jürgen R. Reichenbach1,2,3,4,5 | ||
1Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Jena, Germany, 2Institute of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University, Jena, Germany, 3Michael Stifel Center for Data-driven and Simulation Science, Friedrich Schiller University, Jena, Germany, 4Abbe School of Photonics, Friedrich Schiller University, Jena, Germany, 5Center of Medical Optics and Photonics, Friedrich Schiller University, Jena, Germany |
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Keywords: Muscle, Quantitative Imaging It is well established in literature that MRI quantitative parameters such as T2 or diffusion coefficients change significantly immediately after a strenuous exercise session. In this work, we instead focus on the long-term effects of regular repeated physical activity on three cohorts characterized by different training regimes. A multiparametric protocol was developed to assess T1, T2, fat fraction, and IVIM diffusion values to examine differences in lumbar spine muscle physiology between the different cohorts. |
| 4215 | Computer 130
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Enhanced Precision of the OXPHOS Measurement with integrated CrCEST MRI and Down Field Proton MR Spectroscopy |
| Dushyant Kumar1, Ryan Armbruster1, Blake Benyard1, Ravi Prakash Reddy Nanga1, Neil Wilson1, and Ravinder Reddy1 | ||
1Radiology, University of Pennsylvania, Philadelphia, PA, United States |
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Keywords: Muscle, CEST & MT, creatine kinase; OXPHOS; Oxidative Phosphorylation Creatine recovery time constant (τCr) of exercised muscle is strongly coupled to net mitochondrial oxidative phosphorylation. However, local in vivo pH drop plays the role of a potential confounder, leading to significantly slower creatine recovery. Even under the same prescribed exercised regime, the extent of acidification and hence its impact on τCr would be variable across participant. To the best of our knowledge, this is the first study where downfield 1H-MR spectroscopy and 3D creatine chemical exchange saturation transfer are extensively used to prescribe mild exercise regime in terms of maximal voluntary contraction of participants while avoiding any acidification. |
| 4216 | Computer 131
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Monitoring of T2 changes in skeletal muscles using multiple overlapping-echo detachment imaging |
| Qizhi Yang1, Jiechao Wang1, Hongjian He2, Jianhui Zhong2,3, Congbo Cai1, Zhong Chen1, and Shuhui Cai1 | ||
1Xiamen University, Xiamen, China, 2Zhejiang University, Hangzhou, China, 3University of Rochester, Rochester, NY, United States |
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Keywords: Muscle, Muscle, multiple overlapping-echo detachment imaging Quantitative magnetic resonance imaging (qMRI), a noninvasive imaging tool without ionizing radiation, provides quantitative physiological information, whilst its lengthy scan time hinders its application in dynamic or real-time scenarios. Herein, the MOLED, a single-shot qMRI method we proposed previously, was applied in an ischemia and post-occlusive reactive hyperemia experiment to measure the T2 variation of the musculoskeletal system. The results disclose regular T2 fluctuations of different muscles during different periods. Inter-day repeatability experiments demonstrate that our method is accuracy and reliable. |
| 4217 | Computer 132
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Diffusion Tensor Imaging of Swimmers’ Supraspinati: Fiber Distinctions Between Sprint and Distance Freestyle |
| Grant M Shoults1, Evan Gold1, Feliks Kogan1, and Valentina Mazzoli1 | ||
1Radiology, Stanford University, Stanford, CA, United States |
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Keywords: Muscle, Diffusion Tensor Imaging Knowledge surrounding post-injury supraspinati in swimmers is vast, however a deep, preventative understanding at the cellular and fiber level is lacking. Through DTI, sixteen elite college swimmers were analyzed to evaluate mechanically stress induced differences between sprint and distance freestylers. Significant results (p-value<0.05) were found between groups for λ1, λ2, λ3, RD, MD, and volume. Findings indicated sprinters having a significantly larger MD and RD which was not compatible with the heightened levels microtrauma associated with aerobic distance training. DTI’s ability to inspect microstructural characteristics may pose it as an addition tool to conventional imaging techniques for athletes. |
| 4218 | Computer 133
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Quantitative MRI of the upper arm in Duchenne muscular dystrophy: Consistent slice positioning is crucial due to fat-fraction variability |
| Michel Cakici1, Donnie Cameron2, Karin J Naarding1,3, Erik H Niks1, and Hermien E Kan2 | ||
1Neurology, Leiden University Medical Center, Leiden, Netherlands, 2C J Gorter MRI Center, Leiden University Medical Center, Leiden, Netherlands, 3Rehabilitation, Amsterdam University Medical Center, Amsterdam, Netherlands |
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Keywords: Muscle, Fat, Neuromuscular Skeletal muscle fat fraction determined using quantitative MRI is a promising outcome measure in Duchenne muscular dystrophy (DMD). However, fat fraction varies along the length of muscles in the lower limb, hampering consistency of longitudinal assessments. Our results show that fat fraction also varies over muscles in the upper limb. This variability is reduced when assessments are standardized at 40% of the humerus length. This is important for reproducibly measuring the fat fraction in the muscles of the upper limb in DMD in clinical trials and follow-up. |
| 4219 | Computer 134
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Quantitative evaluation of gluteal and multifidus muscle atrophy and fatty infiltration in patients with lumbosacral nerve root compression |
| Shi Yin1 and Dou Weiqiang2 | ||
1The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2GE Healthcare, MR Research, Beijing, P.R. China, Beijing, China |
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Keywords: Muscle, Quantitative Imaging This study aims to investigate if MR technology can be applied to quantitatively evaluate the atrophy and fatty infiltration of gluteal and multifidus muscles in patients with lumbosacral nerve root compression. By quantitative evaluating 88 patients, we found the the change of multifidus muscle is related to the level of compressed nerve root and duration. As an indirect manifestation of nerve root compression, muscle change can help diagnosis in conventional lumbar MR images. Muscle content, especially that of multifidus is suggested to be a good indicator to complete the postoperative evaluation. |
| 4220 | Computer 135
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Dynamic T2 mapping following muscle exercise measured by fast spin-echo and ultrafast spin-echo EPI |
| Jaekyun Ryu1, Won Beom Jung1, Chuluunbaatar Otgonbaatar2, Jinil Park3, Juho Kim1, Jeonghak Song4, and Hackjoon Shim1,4 | ||
1Medical Imaging AI Research Center, Canon Medical Systems Korea, Seoul, Korea, Republic of, 2College of Medicine, Seoul National University, Seoul, Korea, Republic of, 3Department of Intelligent Precision Healthcare, Sungkyunkwan University, Suwon, Korea, Republic of, 4Magnetic Resonance Business Unit, Canon Medical Systems Korea, Seoul, Korea, Republic of |
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Keywords: Muscle, Muscle The changes in T2 driven by water content, oxygenation, pH, and blood volume in tissue altered during intense physical activity provides chance to measure the muscle performance. In this study, we investigated feasibility of dynamic T2 measurement for exercise-induced thigh muscle activity using conventional fast spin-echo (FASE, Fast Advanced Spin Echo) and ultrafast spin-echo EPI (SE-EPI) with 3T MRI. |
| 4221 | Computer 136
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Longitudinal evaluation of fasciculation in a healthy population using muscle DTI |
| Linda Heskamp1, Lara Schlaffke2, and Martijn Froeling1 | ||
1Radiology, University Medical Centre Utrecht, Utrecht, Netherlands, 2Neurology, BG-University Hospital Bergmannsheil gGmbH, Bochum, Germany |
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Keywords: Muscle, Muscle Spontaneous motor unit (MU) contractions (fasciculation) are a hallmark of motor neuron diseases and can be measured with motor unit MRI. Previous work used a dedicated sequence with one optimized b-value. Here, we demonstrated that muscle DTI with variable b-values can also detect fasciculation. This allows simultaneous assessment of muscle architecture and fasciculation. Furthermore, we presented a retrospective analysis of fasciculation in healthy cohort muscle DTI data. This reveals higher and more variable fasciculation in lower legs compared to upper legs, and stable fasciculation distribution in repeated measures. Fasciculation detection in patients should therefore preferably focus on the upper legs. |
| 4222 | Computer 137
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Fat Free Muscle Area measurement based on clinical liver MRI workflow to assess sarcopenia |
| Xin Shi1, Yueluan Jiang2, Lei Zhang1, Jiping Wang1, Dongdong Qiu1, and Shiyu Guo1 | ||
1the First Hospital of Jilin University, Changchun, China, 2MR Scientific Marketing, Siemens Healthineers, Beijing, China |
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Keywords: Muscle, Fat Fat free muscle area (FFMA) is an important measurement to evaluate sarcopenia and myosteatosis, and it is associated with poor prognosis in patients with chronic liver and oncologic diseases. FFMA was measured on T2WI-TSE sequence in previous study, which is not in routine MRI workflow, and the scanning time of T2WI-TSE sequence is obviously longer than T1WI edixon sequence, so we develop a method to measure FFMA by T1WI edixon sequence in clinical liver MRI sequence and explore a clinical friendly sarcopenia measurement. |
| 4223 | Computer 138
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Longitudinal quantitative imaging of skeletal muscles and peripheral nerves in CMT1A patients using Double-Echo in Steady-State at 7 Tesla |
| Bragi Sveinsson1,2, Robert L Barry1,2,3, Matthew S Rosen1,2,4, and Reza Sadjadi5 | ||
1Radiology, Massachusetts General Hospital, Boston, MA, United States, 2Radiology, Harvard Medical School, Boston, MA, United States, 3Harvard-MIT Health Sciences and Technology,, Cambridge, MA, United States, 4Physics, Harvard University, Cambridge, MA, United States, 5Neurology, Massachusetts General Hospital, Boston, MA, United States |
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Keywords: Nerves, Quantitative Imaging Charcot-Marie-Tooth (CMT) is a neuromuscular disease causing progressive loss of muscle mass and function as well as nerve damage. Quantitative MRI offers the ability to investigate the condition of nerves and skeletal muscle non-invasively. In this work, we report findings from measuring various quantitative neuromuscular metrics in four CMT1A patients in high-resolution images obtained at 7T, measured at two time points. |
| 4224 | Computer 139
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Magnetic resonance fingerprinting thermometry (MRFT) versus PRFS thermometry: comparative temperature prediction in ex vivo bovine muscle |
| Enlin Qian1, Pavan Poojar2, Maggie Fung3, Zhezhen Jin4, John Thomas Vaughan1, Devashish Shrivastava1, David Gultekin1, and Sairam Geethanath2 | ||
1Columbia Magnetic Resonance Research Center, Columbia University, New York, NY, United States, 2Accessible MR Laboratory, Biomedical Engineering and Imaging Institute, Dept. of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mt. Sinai, New York, NY, United States, 3GE Healthcare, New York, NY, United States, 4Department of Biostatistics, Columbia University, New York, NY, United States |
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Keywords: Safety, Safety We explored T1-based magnetic resonance fingerprinting thermometry (MRFT) and compared it with proton resonance frequency shift (PRFS) thermometry in ex vivo bovine muscle data. We conducted temperature sensitivity calibration experiments for both methods. We compared MRFT and PRFS thermometry predicted temperatures in bovine muscles, validated by fluoroptic probe measurements. We observed strong correlation in temperature sensitivity calibration experiments (R2>0.958). Both methods predict temperature accurately (RMSE<1.37 ℃ and RMSE<0.93 ℃ for MRFT and PRFS, over a range of 25 ℃). We observed strong correlation between PRFS and MRFT predicted temperature in heated bovine muscle (R2>0.93). |
| 4225 | Computer 140
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Estimation of isotropic and anisotropic biomechanical properties of the lower leg muscle during muscle contraction using DTI and MR elastography |
| Mahsa Salimi Majd1, Yang Yang1, Heiko Tzschätzsch1, Steffen Görner1, Jürgen Braun1, Ingolf Sack1, and Jing Guo1 | ||
1Charité - Universitätsmedizin Berlin, Berlin, Germany |
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Keywords: Elastography, Elastography In this study, DTI and multifrequency MR elastography (MRE) were applied to 6 subjects to investigate the changes of fiber orientation and the biomechanical properties of the lower leg muscle during passive plantarflexion and dorsiflexion. Using the pentation angle estimated from DTI, MRE data were processed to obtain both isotropic shear wave speed (c) and anisotropic shear moduli (μ12, μ13) as well as Young’s modulus (E3). Preliminary findings showed significant changes of the biophysical properties upon lower leg muscle contraction. |
| 4362 | Computer 101
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A single-sided NMR approach to study structural differences of the articular cartilage tissue |
| Carlo Golini1, Claudia Testa1, Anastasiia Nagmutdinova2, Villiam Bortolotti2, and Leonardo Brizi1 | ||
1Department of Physics and Astronomy "Augusto Righi", University of Bologna, 40127 Bologna, Italy, 2Department of Civil, Chemical, Environmental, and Materials Engineering, University of Bologna, 40134 Bologna, Italy |
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Keywords: Cartilage, Relaxometry, Single-sided NMR In the last decade, few preliminary low-field relaxometry studies were conducted on the articular cartilage using the single-sided NMR-MOUSE device that can be useful for osteoarthritis characterization. This study aims to develop a procedure capable of quantitatively evaluating the structure of the three cartilage layers. Forty osteochondral cylindrical bovine knee specimens were analyzed obtaining four NMR parameters T1, T2, D, and α (extracted from a Double-Quantum-like sequence for solid/liquid estimation) for each cartilage layer. Significant discrimination of the three layers was found by all the parameters, making the NMR dataset sensitive to structural differences and changes due to cartilage diseases. |
| 4363 | Computer 102
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An application of parallel imaging and deep-learning reconstructed T2 mapping in nasal cartilage |
| Weiyin Vivian Liu1, Yufan Gao2, and Yunfei Zha2 | ||
1GE Healthcare, Beijing, China, 2Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, China |
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Keywords: Cartilage, Cartilage Rhinoplasty is a reversible surgery; MRI became a non-invasive post-surgery tracking approach to assess the influence of implant-compressed on nasal cartilage such as mechanical stress, cellular organization and tissue degeneration, etc. Widely-used T2 mapping in musculoskeletal imaging such as knee, shoulder and pelvics takes long acquisition time and thus deters clinical utility. With greater number of multi-channel coils and parallel imaging techniques, scan time shortens but noise enhances. With the additional deep-learning reconstruction, T2 mapping with parallel imaging was stable with small RMS CV% = 0.077% to parallel imaging only image data sets. |
| 4364 | Computer 103
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T2 Relaxation Time Decreases in Regions of Loaded Contact in Superficial and Deep Layers of Articular Cartilage |
| Natasha M. Bzowey1, Marianne S. Black2, Lumeng Cui3, Chelsey S. Thorson1, Madeline M. Martel1, and Emily J. McWalter1 | ||
1Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, 2Mechanical Engineering, University of Victoria, Victoria, BC, Canada, 3Siemens Healthcare Ltd., Burnaby, BC, Canada |
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Keywords: Cartilage, Joints The aim of this work was to identify focal changes in T2 relaxation times inside and outside regions of tibiofemoral contact in loaded cadaver knee articular cartilage whole, superficial, and deep layers. We used a cluster analysis approach to identify regions of change in T2 relaxation time. We found that 1) decreases in T2 relaxation time with load appeared predominantly inside of the femoral and tibial cartilage contact areas, and 2) greater decreases in T2 within the tibial and femoral cartilage contact area were observed in the superficial layer of cartilage. |
| 4365 | Computer 104
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Comparing the effect of body weight, BMI and physical activity intensity on calcified and uncalcified cartilage using quantitative UTE MRI |
| Hanqi Wang1, Qing Li2, Stefan Sommer3,4,5, and Yong Lu1 | ||
1Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 2MR Collaborations, Siemens Healthineers Ltd., Shanghai, China, Shanghai, China, 3Siemens Healthineers International AG, Zurich, Switzerland, Zurich, Switzerland, 4Swiss Center for Musculoskeletal Imaging (SCMI), Balgrist Campus, Zurich, Switzerland, Zurich, Switzerland, 5Advanced Clinical Imaging Technology (ACIT), Siemens Healthineers International AG, Lausanne, Switzerland, Lausanne, Switzerland |
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Keywords: Cartilage, Cartilage UTE technique was utilized to quantitatively assess calcified cartilage (CC) and uncalcified cartilage (UC). T2* values of UC in patella, medial tibia and lateral femur positively moderately correlated with body weight, while T2* values of CC showed no significant correlation. T2* values of UC showed no significant correlation with BMI, while T2* values of CC in medial femur and lateral tibia showed negatively strong and positively moderate correlation, respectively. T2* values of CC and UC showed no significant correlation with physical activity level. The mechanical loading effect performs different between CC and UC, indicating their different bio-mechanical properties. |
| 4366 | Computer 105
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Deep-learning based fast spin echo magnetic resonance imaging improved clarity of nasal cartilage |
| yufan Gao1, yunfei zha1, and Weiyin Vivian Liu2 | ||
1renmin hospital of wuhan university, wuhan, China, 2GE Healthcare, MR Research China, beijing, China |
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Keywords: Cartilage, Cartilage In this study, a comparative study of the original images (T1WI, T2WI) and ARDL images based on deep learning reconstruction (T1WI-DL, T2WI-DL) was conducted for magnetic resonance imaging of nasal cartilage. We aim to evaluate the feasibility and performance of a novel deep learning based MRI reconstruction method to show the structures of nasal cartilage, especially lower lateral cartilage. The results showed that applying ARDL to nasal cartilage MRI showed significant improvement in both SNR and CNR. we conclusion that the DL-based reconstruction algorithm was feasible to be applied to nasal cartilage MRI and improve the image quality. |
| 4367 | Computer 106
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Automated Principal Component Analysis of cartilage thickness, T2 times and bone shape as interpretable model for osteoarthritis progression |
| Felix G Gassert1, Gabrielle Hoyer1, Jenny Lee1, Kenneth Gao1, Aniket Tolpadi1, Valentina Pedoia1, and Sharmila Majumdar1 | ||
1Radiology, Center for Intelligent Imaging, UCSF, San Francisco, CA, United States |
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Keywords: Osteoarthritis, Cartilage In this study we used fully automatic segmentations of the bones and the cartilage of the knee to perform a principal component analysis of cartilage thickness, T2-relaxation times and bone shapes in the Osteoarthritis Initiative Dataset. We extracted and visualized the principal components which significantly contributed to a model for prediction of osteoarthritis progression to (i) show that besides mean values of these parameters also their distribution is crucial for osteoarthritis progression and (ii) prove the feasibility of visual interpretation of these components for better understanding factors associated with the disease. |
| 4368 | Computer 107
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Relaxation Anisotropy Mapping of Articular Cartilage at 3 T |
| Ville Kantola1,2, Jouni Karjalainen1,2, Victor Casula1,2, Mikko J. Nissi3, and Miika T. Nieminen1,2,4 | ||
1Research Unit of Health Science and Technology, University of Oulu, Oulu, Finland, 2Medical Research Center, University of Oulu, Oulu, Finland, 3University of Eastern Finland, Kuopio, Finland, 4Department of Diagnostic Radiology, University of Oulu, Oulu, Finland |
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Keywords: Cartilage, Relaxometry, Relaxation anisotropy The study of T2 and T1ρ anisotropy in musculoskeletal tissues, arising from the orientation of collagen fibrils in tissue, has so far been limited to experimental MRI systems. Here we present a method for measuring relaxation anisotropy ex vivo on a clinical MRI system. Furthermore, we aimed to quantify and compare the degrees of orientation dependence in bovine articular cartilage through anisotropy mapping. T2 and T1ρ mapping was performed on bovine stifle joint samples at multiple sample orientations. After coregistration anisotropy maps were created using Michelson contrast. The results showed large variations in anisotropy across cartilage thickness and topographical locations. |
| 4369 | Computer 108
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Assessment of articular cartilage in response to an impact injury using µMRI |
| Amanveer Singh1, Hannah Mantebea2, Farid Badar2, Syeda Batool2, Gabrielle Abdelmessih3, Talia Sebastian3, Michael Newton4, and Yang Xia2 | ||
1Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI, United States, 2Department of Physics and Center for Biomedical Research, Oakland University, Rochestor, MI, United States, 3Department of Chemistry, Oakland University, Rochestor, MI, United States, 4Beaumont Hospital, Royal Oak, MI, United States |
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Keywords: Cartilage, Osteoarthritis, Osteoarthritis, Cartilage, Impact injury This project aimed to study the properties of articular cartilage in response to mechanical injury in rabbit knees using μMRI. Femoral cartilage bone plugs were excised 2 and 14 weeks after impact and imaged using μMRI at a resolution of 11.7 μm/pixel. Higher T2 relaxation values in affected specimens illustrated deterioration in the cartilage after impact. Furthermore, the higher T2 values in impacted samples of the 14-week batch compared to the 2-week batch indicate progressive cartilage degradation over time. |
| 4370 | Computer 109
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Orientation-independent T2 relaxation parameters and biomechanics of healthy and degenerated human articular cartilage |
| Henri P.P. Leskinen1,2, Juuso Tuppurainen1,3, Jiri Jäntti1,3, Janne T.A. Mäkelä1,3, and Mikko J. Nissi1 | ||
1Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 2Mikkeli Central Hospital, Mikkeli, Finland, 3Kuopio University Hospital, Kuopio, Finland |
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Keywords: Cartilage, Osteoarthritis Variation in T2 relaxation has been linked to changes in articular cartilage degenerative status. Most prominently to the collagen network integrity. However, T2 is greatly anisotropic in highly organized tissues, e.g. articular cartilage. Previous results show that using re-orientation experiments, orientation-independent T2 components can be defined. This study assesses the potential of these parameters to serve as biomarkers for osteoarthritis via comparing the orientation-independent T2 parameters to biomechanical testing results in human articular cartilage. Changes in the anisotropic component of T2 in the superficial and transitional zones are observed along with the biomechanical degeneration of the articular cartilage. |
| 4371 | Computer 110
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Improved identification of cartilage lesion in chondromalacia patellae (CMP) with 7.0 T MRI compared with 3.0T MRI: a preliminary study |
| Yan Wang1, Jiayu Huang1, Jianxun Qu2, Xiangbing Bian1, Caohui Duan1, Chunbao Li3, Jing Zhang1, and Xin Lou1 | ||
1Radiology, PLA general hospital, Beijing, China, 2MR Collaboration, Siemens Healthineers Ltd, Beijing, China, 3Orthopaedics, PLA general hospital, Beijing, China |
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Keywords: Cartilage, Cartilage To compare the ability in revealing subtle changes of patellar cartilage in suspected CMP between 7.0T and 3.0T MRI. We documented the total number of identified cartilage lesions by two radiologists and compared the number of cartilage lesions identified between 3.0T and 7.0T MRI. The result showed good consistency between readers. The mean number of cartilage lesions identified on 3.0T images was significantly less than 7.0T images. Considering the preliminary and small-sample feature of the study, we conclude conservatively that compared with 3.0T MRI, 7.0T MR images reveal more lesion of the patellar cartilage in CMP patients. |
| 4372 | Computer 111
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T2 and T1rho mapping of equine metacarpophalangeal joint cartilage |
| Carly Lockard1, Brad Sutton2, Bruce Damon1, Xiaojuan Li3, and Annette McCoy4 | ||
1Stephens Family Clinical Research Institute, Carle Clinical Imaging Research Program, Carle Health, Urbana, IL, United States, 2The Grainger College of Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States, 4Department of Veterinary Clinical Medicine (College of Veterinary Medicine), University of Illinois, Urbana, IL, United States |
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Keywords: Cartilage, Quantitative Imaging Horses are an excellent translational model of orthopedic disease with high relevance to human disease. T2 and T1rho mapping can provide information about early cartilage changes in a horse post-traumatic osteoarthritis model. We investigated the feasibility of using MAPSS-based T2 and T1rho mapping in the horse metacarpophalangeal joint cartilage in cadaver specimens and live horses with and without joint pathology. MAPSS-based T2 and T1rho mapping of equine metacarpophalangeal joint cartilage is feasible and provides realistic cartilage relaxometry values. |
| 4373 | Computer 112
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Evaluating the relationship of proximal femoral bone shape asymmetry with cartilage health and biomechanics in patients with hip OA |
| Rafeek Thahakoya1, Valentina Pedoia1, Kenneth Gao1, Rupsa Bhattacharjee1, Felix Gassert1, Johanna Luitjens1, Koren Roach1, Eric Hammond1, Richard Souza1,2, and Sharmila Majumdar1 | ||
1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, United States |
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Keywords: Bone, Osteoarthritis This current study evaluated the role of bone shape asymmetry with other biomarkers of hip OA such as T1rho/T2 relaxation time and gait biomechanics data. We observed similar relationship trend in higher bone asymmetry values in the AMS region correlates with lesser number of repetitions performed 30s chair rise test, validating the common understanding of performance. This is one of the first feasibility studies to be explored which conveys the potential of bone asymmetry to be considered as a strong biomarker for understanding hip OA |
| 4374 | Computer 113
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Evaluation of the effect on quantitative ultrashort echo time (UTE) biomarkers with cartilage dehydration and rehydration |
| Lidi Wan1, Adam Searleman2, Yajun Ma2, Jonathan H Wong3, Guangyu Tang1, Jiang Du2, and Eric Y Chang3 | ||
1Radiology, Tenth People's Hospital of Tongji University, Shanghai, China, 2Radiology, University of California, San Diego, San Diego, CA, United States, 3Radiology, VA San Diego Healthcare System, San Diego, CA, United States |
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Keywords: Cartilage, Quantitative Imaging Ex vivo and cadaveric articular cartilage samples often undergo freeze and thaw cycles and sample preparation in air. These procedures will result in cartilage dehydration and degradation, which may affect the results of UTE-biomarkers. This study was aimed to evaluate the effect of cartilage dehydration and rehydration on UTE-biomarkers and to compare the rehydration capability of synovial fluid and normal saline. Cartilage dehydration resulted in significant changes in all evaluated UTE-biomarkers. Rehydrating with normal saline had non-significant effect on UTE-biomarkers while synovial fluid resulted in significant changes for MMF and T2*. Rehydrating with normal saline is better than synovial fluid. |
| 4375 | Computer 114
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CRLB minimization for optimal Multi Spin-Echo T2-mapping of the cartilage using dictionary-based estimation |
| Tiago Timoteo Fernandes1,2, Sairam Geethanath2, and Rita G Nunes3 | ||
1nstitute for Systems and Robotics - Lisboa and Department of Bioengineering, Instituto Superior Técn, Lisboa, Portugal, 2Accessible Magnetic Resonance Laboratory, Biomedical Imaging and Engineering Institute, Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, New York, NY, United States, 3Institute for Systems and Robotics - Lisboa and Department of Bioengineering, Instituto Superior Técnico – Universidade de Lisboa, Lisbon, Portugal, Lisboa, Portugal |
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Keywords: Cartilage, Quantitative Imaging .We compared Cramer-Rao Lower Bounds of Multi Spin-Echo sequences’ derived T2 values using a dictionary approach for musculoskeletal relaxometry. The refocusing flip angle, inter-echo spacing and echoe number were varied, constraining the B1+rms to 5μT and the exam time to 9 minutes, keeping TR to a minimum. Designed sequences were tested in NIST/ISMRM phantom and ex vivo, and compared against the vendor’s MSE. A repeatability study was performed during 5 days. An optimized sequence with target T2 value (45ms), representative of the cartilage, scored below 10% for Within-case Coefficient of Variation in 9 out of 14 vials. |
| 4376 | Computer 115
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Increased accuracy in relaxometry estimates through statistical determination of the noise floor |
| Laurel Hales1, Ananya Goyal1, and Feliks Kogan1 | ||
1Radiology, Stanford University, Stanford, CA, United States |
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Keywords: Cartilage, Relaxometry, low SNR Including data below the noise floor in estimating relaxometry values leads to overestimation. It is possible to identify and remove data below the noise floor by considering the set of voxel data in an ROI at each echo time as a separate but related dataset, and then comparing the data from each echo time statistically. Removing data below the noise floor, reduces error in the estimates of relaxometry values. |
| 4377 | Computer 116
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Quantitative MRI T2mapping in the knee joint using deep learning-based reconstruction for Compressed sensing |
| jiahui fu1, chinting wong1, lin mu1, dong dong1, ying qiu1, yi Zhu2, Ke Jiang2, and huimao zhang1 | ||
1The First Hospital of Jilin University, Changchun, China, chang chun, China, 2Philips Healthcare, Beijing, China, Beijing, China, China |
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Keywords: Osteoarthritis, Machine Learning/Artificial Intelligence MRI T2 mapping has been recommended as a noninvasive biomarker of knee cartilage lesions. However, due to the long acquisition time, it hasn’t been widely used in the clinical setting. Recently, deep learning-based acceleration of compressed sensing (CS) has shown promising results without losing image quality. The purpose of this study was to explore the feasibility of quantitative knee T2-mapping accelerated by deep learning-based compressed sensing (CS-AI), and compare the image quality and diagnostic performance with conventional CS. The results demonstrates that quantitative knee T2 mapping with reconstruction by CS-AI was feasible, suggesting better diagnostic performance without extra time consuming. |
| 4378 | Computer 117
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RADIOMICS FEATURES OF INFRAPATELLAR FAT PAD ASSOCIATED WITH POST-TRAUMATIC OSTEOARTHRITIS AT 10+ YEARS AFTER ACL RECONSTRUCTION |
| Sameed Khan1,2,3, Richard Lartey1,2, Nancy Obuchowski1,4, Sibaji Gaj1,2, Jee Hun Kim1,2, Mei Li1,2, Brendan Eck1,3, Carl S. Winalski1,2,3, Faysal Altahawi1,3, Morgan H Jones5, Laura J Huston6, Kevin D Harkins7, Michael V Knopp8, Christopher C Kaeding9, Kurt Spindler1,10, and Xiaojuan Li1,2,3 | ||
1Program of Advanced Musculoskeletal Imaging, Lerner Research Institute, Cleveland, OH, United States, 2Department of Biomedical Engineering, Lerner Research Institute, Cleveland, OH, United States, 3Department of Diagnostic Radiology, Imaging Institute, Cleveland, OH, United States, 4Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland, OH, United States, 5Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA, United States, 6Department of Orthopedics and Rehabilitation, Vanderbilt University, Nashville, TN, United States, 7Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 8Wright Center of Innovation in Biomedical Imaging, Ohio State University, Columbus, OH, United States, 9Department of Orthopedic Surgery, The Ohio State University, Columbus, OH, United States, 10Department of Orthopedic Surgery, Cleveland Clinic, Cleveland, OH, United States |
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Keywords: Osteoarthritis, Fat ACL injury is a major risk factor for post-traumatic osteoarthritis (PTOA), however mechanisms are not fully understood. In this work, we use radiomics from quantitative MRI imaging to associate subvisual changes in the infrapatellar fat pad (IPFP) to both symptomatic and radiographic PTOA. MRI was collected from 113 patients at least 10 years post-ACLR. 1690 radiomics and 11 clinical features were extracted and selected using a gradient-boosted decision tree classifier model. A subset of texture-associated features of IPFP and no clinical features were associated with symptomatic PTOA with an AUROC of 0.74 and radiographic PTOA with an AUROC of 0.84. |
| 4379 | Computer 118
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Quantitative 3D Assessment of Meniscus in Patients with Posterior Root Tears and Healthy Controls Using T2* Mapping at 7T |
| Abdul Wahed Kajabi1,2, Stefan Zbyn1,2,3, Jesse Smith1,2, Morgan Homan4, Hasan Abbasguliyev5, Ariel N. Rodriguez4, Gregory J. Metzger1, Robert F. F. LaPrade4, and Jutta M. Ellermann1,2 | ||
1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 3Department of Biomedical Engineering, Lerner Research Institute, Ohio, OH, United States, 4Twin Cities Orthopedics, Edina, MN, United States, 5Department of Diagnostic and Interventional Radiology, Ataturk University Research Hospital, Erzurum, Turkey |
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Keywords: MSK, Quantitative Imaging, Meniscus Evaluating 3D T2* mapping of the meniscus at ultra-high field 7T provides necessary high resolution to better characterize tissue changes in the meniscus. This study was designed to measure the 3D structure of the meniscus with T2* mapping in a clinically acceptable scan time at 7T, and to evaluate meniscus degeneration in twelve patients with arthroscopically verified tears of the posterior horn of the medial meniscus and nine age, sex and body mass index matched healthy controls. T2* mapping at 7T provided comprehensive 3D evaluation of meniscus and detected degenerative alterations caused by the root tears in the patients. |
| 4380 | Computer 119
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Isotropic 3D MRI determined labral tear extent correlates with hyaline cartilage loss in hip dysplasia patients |
| Shuda Xia1, Avneesh Chhabra2, Gaurav Sharan2, Uma Thakur2, Holden Archer2, Yin Xi2, and Joel Wells2 | ||
1University of Texas Southwestern Medical Center, Plano, TX, United States, 2University of Texas Southwestern Medical Center, Dallas, TX, United States |
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Keywords: Joints, Joints This study is a novel investigation into the clinical correlations between parameters measured through 3D MRI and outcomes for patients with hip dysplasia (HD). Although there were no statistically significant correlations seen between labral tear length and PROMs (p>0.05), a few non-significant correlation trends were observed. Furthermore, labral tear lengths directly positively correlated with worsening cartilage damage, the presence of subchondral bone cysts, para-labral cysts, and the number of labral tears seen. |
| 4381 | Computer 120
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Relaxometric mapping of normal tissue using magnetic resonance fingerprinting (MRF) |
| Enlin Qian1, Amaresha Shridhar Konar2, Tiago Fernandes3, Ramesh Paudyal2, Amita Shukla-Dave2,4, Lawrence Schwartz5, and Sairam Geethanath3 | ||
1Columbia Magnetic Resonance Research Center, Columbia University, New York, NY, United States, 2Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3Accessible MR Laboratory, Biomedical Engineering and Imaging Institute, Dept. of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mt. Sinai, New York, NY, United States, 4Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 5Department of Radiology, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, NY, United States |
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Keywords: Muscle, Muscle We explored the feasibility of T1 and T2 mapping of normal tissue (masseter muscle) in the head and neck (HN) region using magnetic resonance fingerprinting (MRF) and evaluated its repeatability. Our study included fingerprinting data from four healthy volunteers and four repeats each, along with acquiring B0 maps. The T1 and T2 estimation of masseter muscle by MRF is similar to previous literature values. We report wCV<4.3% for T1 measurements and wCV<7% for T2 measurements for all subjects. No significant B0 variations were observed in the masseter muscle regions. |
| 4524 | Computer 101
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Correlation of R2* with fat fraction and bone mineral density and its role in quantitative assessment of osteoporosis |
| zhenghua Liu1 | ||
1Radiology, Honghui Hospital Affiliated Xi’an Jiaotong University, xi an, China |
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Keywords: Bone, Quantitative Imaging, Osteoporosis; Bone density In this study, we investigated the relationship between vertebral R2* and FF based on IDEAL-IQ sequences and BMD based on QCT, and then performed diagnostic experiments. The results revealed a definite but weak linear relationship between R2* with FF and BMD, which has limited value as a diagnostic indicator for OP and osteopenia, but has some potential as a complement to FF and BMD for fine quantification of bone marrow conversion and bone mineral loss. |
| 4525 | Computer 102
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Assessment of vertebral and intervertebral disc microenvironment changes in postmenopausal women using IVIM and fat-water MRI |
| Shuo Zhang1, Qingwei Song1, Hongbo Feng1, Qianrui Guo2, and Yang Yang3 | ||
1The First Affiliated Hospital of Dalian Medical University, Dalian, China, 2Dalian Medical University, Dalian, China, 3Beijing United Imaging Research Institute of Intelligent Imaging, Beijing, China |
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Keywords: Bone, Data Acquisition Intravoxel incoherent motion (IVIM) and fat-water magnetic resonance imaging (FWMRI) are rarely used for vertebral and intervertebral disc. To search for predictive value of them in assessing the lumbar spine microenvironment changes, we performed a study with postmenopausal women combined the parameters with bone mineral density (BMD) and major fracture risk assessment (FRAX) score. We report that fat fraction (FF) has significant correlation with FRAX, FF was moderately negatively correlated with BMD; ADCslow of intervertebral discs showed moderately negatively correlation with FRAX score and FF. IVIM and FWMRI have potential to become new biomarkers in predicting lumbar spine microenvironment changes. |
| 4526 | Computer 103
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Application of Multiecho Dixon Technique and IVIM-DWI in Patients with Primary Osteoporosis : A Preliminary Study with 3.0 T MRI |
| fan qiu ju1, tan hui1, yu nan 1, and wang shao yu2 | ||
1Affiliated Hospital of Shaanxi University of Chinese Medicine,, xianyang, China, 2MR senior Scientific Marketing Specialist,Siemens Healthineers, Shang hai, China |
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Keywords: Bone, Quantitative Imaging, Multiecho Dixon Technique , IVIM-DWI Bone mineral density (BMD) is a common standard for evaluating osteoporosis, but it can only reflect the change of bone mass, not the microscopic nodules of tissueChange of structure.Multi-echo Dixon and IVIM-DWI were used to evaluate the changes of spinal bone marrow microstructure in osteoporosis, osteopenia and normal subjects.The results showed that there were significant differences in FF, D and D* between osteoporosis, osteopenia and normal subjects.These results indicate that IVIM-DWI can quantitatively reflect the changes of lumbar microcirculation and fat content, and can be used as a biomarker for the progression of osteoporosis. |
| 4527 | Computer 104
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A clinical application of ZTE-MRI in diagnosis of knee using joint space and angles |
| Hui Wang1, Weiyin Vivian Liu2, Wen Chen3, Jingyu Jiang4, Ling Sang3, Peng Zhang3, and Hu Chen3 | ||
1Hubei University of Medicine, Department of Radiology, Taihe Hospital,, Hubei, China, 2GE Healthcare, Beijing, China, 3Shiyan Taihe Hospital, Hubei, China, 4Biomedical Engneering College, Hubei University of Medicine, Hubei, China |
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Keywords: Bone, Bone X-ray showed no significant abnormalities at early stage of OA, but obvious manifestation appeared in the middle and late stages. Our study demonstrated that joint space and joint angle can be measured on ZTE-MRI in evaluation of knee mechanical function and further support anatomical evaluation using Kellgren-Lawrence grading system that is the most widely used method for osteosurgeons in diagnosis of knee osteoarthritis. We also found both JS and CD were correlated with KLZTE score and both showed significant difference between mild/moderate and advanced groups. Therefore, ZTE-MRI has great potential in displaying structure abnormality. |
| 4528 | Computer 105
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Intelligent volume rendering of ZTE MR Bone images |
| Vineet Mehta1, Deepthi Sundaran1, Jignesh Dholakia1, Maggie Fung2, and Michael Carl3 | ||
1GE Healthcare, Bengaluru, India, 2GE Healthcare, New York City, NY, United States, 3GE Healthcare, San Diego, CA, United States |
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Keywords: Bone, Visualization, Volume Rendering This study presents a new Deep-Learning (DL) based processing pipeline to enable one-click volume rendering of MR Bone Zero TE (ZTE) images. It comprises of DL based background subtraction followed by histogram adjustment. A comparison with existing algorithms demonstrates that the proposed method prevails in accuracy of background subtraction (DICE = 0.97) and eliminates the tedious, error-prone manual steps of segmentation and histogram adjustment required to prepare the data for usable volume rendering. It can also be used universally across anatomies as opposed to other methods requiring anatomy-specific tuning. |
| 4529 | Computer 106
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Quantification of the effects on proximal femur trabecular bone biometrics by parallel imaging and compressed sensing reconstruction |
| Brian-Tinh Duc Vu1,2, Brandon C. Jones1,2, Rajiv S. Deshpande1,2, Hyunyeol Lee2,3, Trevor J. Chan1,2, Nada Kamona1,2, Sabrina Ripsman2, Dilini Ranaweera2, and Chamith S. Rajapakse2,4 | ||
1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 3School of Electronics Engineering, Kyungpook National University, Daegu, Korea, Republic of, 4Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, United States |
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Keywords: Bone, Bone, Osteoporosis The high resolution needed for quantification of trabecular bone biometrics in the proximal femur results in a prohibitively long scan time for clinical screening. Parallel imaging and compressed sensing (PICS) can reduce scan times by undersampling k-space while producing images comparable in quality to that of the Nyquist-sampled scan. Here, we show PICS recovers information on the trabecular microarchitecture at a quality comparable to that of Nyquist-sampled 3D balanced steady-state free precession. We quantify several parameters of trabecular bone for various acceleration factors to investigate the upper limit of PICS acceleration for femoral imaging. |
| 4530 | Computer 107
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Q-Dixon and T2 Mapping for assessment of intervertebral disc degeneration in lower back pain |
| Futing Feng1, Wei Wang1, Meining Chen2, Lusi Liu1, Mixue Sun1, and Min Luo1 | ||
1Department of Radiology, Zigong Fourth People's Hospital, Zigong, Sichuan, China, 2Department of MR Scientific Marketing,, Siemens Healthineers, Shanghai, China |
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Keywords: Bone, Degenerative The diagnostic performance of MR T2w-based Pfirrmann classification decreases in early and severe stages in patients with lower back pain(LBP). The MR mapping technique, including q-Dixon and T2 mapping, allows for visualization and quantification of the discs and vertebrae in patients with LBP. The changes of bone marrow fat (BMF), T2 and T2* values can be seen in different pain levels and Pfirrmann classification, with great potential in quantifying biochemical degeneration of the lumbar spine. |
| 4531 | Computer 108
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Toward an Imaging Biomarker for Proximal Femur Fracture Risk Using 3T Chemical Shift-Encoded MRI Radiomic Of Bone Marrow |
| Dimitri Martel1, Benjamin Leporq2, Anmol Monga1, Stephen Honig3, and Gregory Chang1 | ||
1Radiology, NYU Langone, New York, NY, United States, 2Université de Lyon; CREATIS CNRS UMR 5220, Inserm U1206, INSA-Lyon, Villeurbanne, France, 3Osteoporosis Center, Hospital for Joint Diseases, NYU Langone, New York, NY, United States |
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Keywords: Bone, Radiomics Recent studies using Chemical Shift Encoded-MRI have used textural analysis to assess vertebral marrow heterogeneities in postmenopausal women and in paraspinal muscle to predict its strength. Radiomics provide another means to quantify bone marrow on MR images, specifically by analyzing texture, shape, and intensity distribution in the region of interest. Our aim was to investigate whether radiomic features in fatty acid composition maps of the proximal femur bone marrow improve the prediction of osteoporotic fracture. |
| 4532 | Computer 109
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3D T2 and T1ρ Mapping of Ischemic Injury to the Femoral Head: An In Vivo Piglet Model Study |
| Erick O. Buko1,2, Douglas Albrecht1, Alexandra R. Armstrong1, Ferenc Tóth1, and Casey P. Johnson1,2 | ||
1Veterinary Clinical Sciences, University of Minnesota, Saint Paul, MN, United States, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States |
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Keywords: Bone, Ischemia Legg-Calvé-Perthes disease (LCPD) is a pediatric hip disorder caused by femoral head ischemia and osteonecrosis. In this work, we investigated whether 3D T2 and T1ρ relaxation time mapping are sensitive to ischemic injury to the bone and marrow of the femoral epiphysis and metaphysis following surgical induction of femoral head ischemia in a piglet model of LCPD. We found that T2 and T1ρ increased in the ischemic femoral epiphysis and decreased in the perfused metaphyseal spongiosa. Our findings support the potential clinical use of T2 and T1ρ mapping to assess the severity of femoral head injury in patients with LCPD. |
| 4533 | Computer 110
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Can Zero Echo Time (ZTE) Magnetic Resonance Imaging Sequences Detect Signal from Collagen Backbone Protons? |
| Dina Moazamian1, Xiaojun Chen1, Arya Suprana1, Andrew Andrew Xia1, Saeed Jerban1, Bhavsimran Malhi1, Michael Carl2, Eric Y Chang1,3, Yajun Ma1, Hyungseok Jang1, and Jiang Du1,3,4 | ||
1Radiology, University of California San Diego, San Diego, CA, United States, 2Radiology, GE Healthcare, San Diego, CA, United States, 3VA San Diego Healthcare System, San Diego, CA, United States, 4Bioengineering, University of California San Diego, San Diego, CA, United States |
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Keywords: Bone, Bone Ultrashort echo time (UTE) and zero echo time (ZTE) sequences have been extensively investigated for imaging of short T2 species. The ZTE sequence has a shorter effective TE than UTE and may be superior in imaging ultrashort T2 species. This study investigated whether ZTE could directly image collagen backbone protons in bovine cortical bone and human patellar tendon samples after D2O exchange and freeze-drying. Our experimental results demonstrate that collagen backbone protons are "invisible" with ZTE, which may not be able to directly image species with T2s of ~10 µs. |
| 4534 | Computer 111
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Evaluation of the application of integrated high-quality intervention mode in large-aperture MRI examination of patients with knee joint injury |
| Jun Zhang1, Lina Zhuang1, Nan Wang2, Lihua Chen2, Qinhe Zhang2, Shuheng Zhang2, Yuyin Man2, Qingwei Song2, and Ailian Liu2 | ||
1Discussion and Conclusions, Dalian, China, 2The First Affiliated Hospital of Dalian Medical University, Dalian, China |
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Keywords: Bone, Bone The integrated high-quality intervention mode is adopted for patients with knee joint injuries, combined with super large aperture magnetic resonance equipment, to effectively relieve the negative emotions of patients, relieve pain, improve scanning efficiency and safety, and enhance scanning efficiency and safety. |
| 4535 | Computer 112
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MRI One-stop-shop for Diagnosis of Shoulder Disease |
| Jienan Wang1, ShuQing Chen2, LiFei Ma2, Rui Zhang2, and XiaoMeng Wu2 | ||
1Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People‘s Hosptial, Shanghai, China, 2Philips, Shanghai, China |
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Keywords: Bone, MSK, MRI One-stop-shop, T2 mapping, FRACTURE (FFE Resembling A CT Using Restricted Echo - spacing) In this study, shoulder imaging was achieved by MRI one-stop imaging, which contained different sequences. After the post-processing, a variety of fusion images could be formed to comprehensively evaluate the soft tissue, nerve, cartilage and bone of the shoulder, and then gave us a comprehensive view of the shoulder. |
| 4536 | Computer 113
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Application of Artificial Intelligence (AI)-assisted compressed sensing technology in ankle joint |
| Nan Wang1, Qingwei Song1, Ailian Liu1, Guobin Li2, Shuheng Zhang2, Yunfei Zhang3, and Yongming Dai3 | ||
1the First Affiliated Hospital of Dalian Medical University, Dalian, China, 2Shanghai United Imaging Healthcare Co., Ltd, Shanghai, China, 3MR Collaboration, Central Research Institute, United Imaging Healthcare, Shanghai, China |
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Keywords: Bone, Joints ACS combines CS, half Fourier HF and parallel imaging (PI), and introduces deep learning neural network as AI module into the reconstruction process. Millions of fully sampled data are used to train AI models, so as to suppress various reconstruction artifacts introduced by traditional acceleration methods under high acceleration factors without affecting anatomy and pathological structures. ACS is used for noise suppression, artifact reduction and information recovery. ACS can effectively correct any major errors of single acceleration methods, thus providing a higher acceleration level for MRI imaging. |
| 4537 | Computer 114
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Application value of compressed sensing-based MR FRACTURE sequence in bone and joint |
| Nan Wang1, Qingwei Song1, Ailian Liu1, Jiazheng Wang2, and Liangjie Lin2 | ||
1the First Affiliated Hospital of Dalian Medical University, Dalian, China, 2Clinical and Technical Support, Philips Healthcare, Beijing, China |
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Keywords: Bone, Bone FRACTURE sequence does not need to control TE time within 1ms, but uses multi-echo three-dimensional fast field echo, FFE) sequence to perform magnetic resonance imaging with fixed echo interval. After scanning, bone images with high contrast and high signal-to-noise ratio can be obtained through echo accumulation, subtraction and gray scale inversion. |
| 4538 | Computer 115
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Evaluation of Potential Benefits of 7T for Knee Epiphyseal Bone Marrow ASL Imaging |
| Xiufeng Li1, Jutta Ellermann1, and Gregory J. Metzger1 | ||
1University of Minnesota, Minneapolis, MN, United States |
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Keywords: Bone, Perfusion, ASL, Knee, 7T, Ultrhigh Field Knee epiphyseal bone marrow ASL imaging (called knee ASL imaging in the following) is challenging due to very low perfusion in epiphyseal yellow bone marrow mainly consisting of fat cells with a sparse network of capillaries. In general, it is known that higher magnetic fields (i.e. ≥7T) can specifically benefit ASL imaging. However, the specific potential benefits in the knee have not been systematically evaluated to date. We have performed theoretical simulations to explore the potential gain for knee ASL imaging at 7T compared to 3T and present our preliminary experimental results comparing both field strengths. |
| 4539 | Computer 116
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Investigation of the fat-bone-muscle connection in osteoporosis and osteoarthritis by 1H MRS |
| Alessandra Maiuro1,2, Daniele Mattioli2, Guglielmo Manenti3, Elena Gasbarra4, Umberto Tarantino4, and Silvia Capuani1,2 | ||
1Physics, CNR Institute for Complex Systems (ISC), Rome, Italy, 2Physics, Sapienza University of Rome, Rome, Italy, 3Diagnostic and Interventional Radiology, Molecular Imaging and Radiotherapy, Policlinico Tor Vergata Foundation, Tor Vergata University of Rome, Rome, Italy, 4Orthopedics and Traumatology, Policlinico Tor Vergata Foundation, Tor Vergata University of Rome, Rome, Italy |
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Keywords: Bone, Spectroscopy, Osteoporosis, Fatty acids, Osteoarthritis, Muscle The metabolic pathways involved in the development of osteoporosis and osteoarthritis, was investigated by SVS1H MRS. Metabolites and fatty acids of the bone marrow and the adjacent muscle of healthy, osteoporotic and osteoarthritic woman were quantified using LCModel. The increase of E23 resonance in muscles is a potential marker of sarcopenia correlated to osteoporosis. The decrease of the L53 resonance in bone marrow highlights the presence of osteoporosis (together with total lipids increase) or osteoarthritis (together with bone marrow water increase). |
| 4540 | Computer 117
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Ultrashort Echo Time, MRI porosity index, and suppression ratio correlate with the cortical bone microstructural and mechanical properties |
| Saeed Jerban 1,2,3, Yajun Ma1,2, Salem Alenezi 4, Dina Moazamian1, Jiyo Athertya1, Hyungseok Jang1,2, Erik Dorthe5, Darryl Dlima5, Gina Woods6, Christine B Chung1,2, Eric Y Chang1,2, and Jiang Du1,2 | ||
1Department of Radiology, University of California, San Diego, La Jolla, CA, USA, San Diego, CA, United States, 2Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, La Jolla, CA, USA, San Diego, CA, United States, 3Department of Orthopedic Surgery, University of California, San Diego, La Jolla, CA, USA, San Diego, CA, United States, 4Research and Laboratories Sector, Saudi Food and Drug Authority, Riyadh, KSA, Riyadh, Saudi Arabia, 5Shiley Center for Orthopedic Research and Education at Scripps Clinic, La Jolla, CA, USA, San Diego, CA, United States, 6Department of Medicine, University of California, San Diego, La Jolla, CA, USA, San Diego, CA, United States |
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Keywords: Bone, Bone The cortical bone porous microstructure can be evaluated using ultrashort echo time (UTE) MRI. UTE-MRI-based evaluation of bone has been underutilized partly due to the high cost and time demands of MRI in general. The porosity index (PI) and the suppression ratio (SR) are two rapid UTE-based bone evaluation techniques (~ 5 mins scan time each), which can potentially reduce the time demand and cost in future clinical studies. We have investigated the relationship of PI and SR measures with human cortical bone microstructural and mechanical properties. PI and SR showed significant correlations with microstructural and mechanical properties. |
| 4541 | Computer 118
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Linearity and Bias of Bone Marrow Relative Fat-fraction Compared to Proton Density Fat-Fraction |
| Matthew Mader, MD1, Diego Hernando, PhD2, Rianne A. van der Heijden, MD PhD1, Scott B. Reeder, MD PhD3, and Ali Pirasteh, MD2 | ||
1Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 3Radiology, Medical Physics, Biomedical Engineering, Medicine, Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States |
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Keywords: Bone, Fat, Fat fraction Bone marrow relative fat-fraction (rFF) measured using dual-echo gradient echo (GRE) in- and opposed phase imaging, has been proposed as an early predictor of treatment response in multiple myeloma. In this work we demonstrate that in patients without known bone marrow pathology (referred for liver fat/iron quantification), bone marrow rFF is unreliable and suffers from large bias when compared with proton density fat-fraction (PDFF), acquired using quantitative chemical-shift encoded (CSE) MRI. Hence, PDFF should be considered for future approaches using bone marrow fat-fraction as a predictor of treatment response in multiple myeloma. |