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| 4116 | Booth 1
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Diagnostic value of NCE-CMRA in detection of inflammatory factors related coronary artery damage in Kawasaki disease |
| Juan Liang1, Yurong Ma1, Na Han1, Kai Ai2, and Jing Zhang1 | ||
1Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China, 2Philips Healthcare, Xi'an, China |
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This study mainly uses the non-contrast whole-heart magnetic resonance coronary angiography (NCE-CMRA) to evaluate coronary artery lesion (CAL) in children with Kawasaki disease (KD), and analyze the mechanism of inflammatory factors in the occurrence and development of coronary artery lesions in KD. Multiple linear regression was used to analyze the correlation between inflammatory factors and the severity of CAL. Platelet, PCT, ESR, CRP, D-dimer, albumin, and leukocyte have certain diagnostic value for KD, among which ESR is the most sensitive. Therefore, NCE-CMRA combined with inflammatory indicators is helpful for early diagnosis and prognostic evaluation of CAL in children with KD. |
| 4117 | Booth 2
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Left ventricular-aorta energy efficiency in patients with repaired tetralogy of Fallot |
| Yu-Ru Yang1, Meng-Chu Chang1, Ming-Ting Wu2, Ken-Pen Weng3, and Hsu-Hsia Peng1 | ||
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 3Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan |
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In this study, we defined a ratio of aortic KE and LV KE to represent LV-Ao efficiency. We aimed to evaluate LV-Ao energy efficiency in rTOF patients and evaluate the relationship between LV-Ao efficiency and RV hypertrophy. The aortic root KE, LV KE, and LV-Ao efficiency in rTOF group were comparable with normal group. The indexed LV-Ao efficiency was negatively correlated with age and RV volumetric parameters. The association between LV-Ao efficiency and age and RV hypertrophy suggested that the adverse interaction between RV and LV was expanded to the aorta in rTOF patients with preserved LV function. |
| 4118 | Booth 3
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Diagnostic value of diffusion-weighted MR imaging in acute myocardial infarction |
| Zhenfeng Lv1, Lianming Wu2, Jilei Zhang3, Weibo Chen3, and Haikun Qi1 | ||
1School of Biomedical Engineering, ShanghaiTech University, Shanghai, China, 2Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 3Philips Healthcare, Shanghai 200040, P. R. China, Shanghai, China |
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Diffusion-weighted imaging (DWI), being able to detect the diffusion of water molecules in the tissue, is one of the potential techniques for the diagnosis of myocardial infarction without contrast agent administration. In this study, we investigated the diagnostic value of the mono-exponential and stretched exponential DWI model in the assessment of acute myocardial infarction. The preliminary results from 10 patients showed that the diffusion parameters were significantly lower in the infarcted region, and both models had capability of diagnosing acute myocardial infarction with the stretched exponential model performing slightly better. |
| 4119 | Booth 4
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Infarct size and strain by cardiac magnetic resonance predict adverse remodeling after ST-segment elevation myocardial infarction |
| Jianing Cui1, Tao Li1, Yanan Zhao1, and Xiuzheng Yue2 | ||
1Department of Radiology, the First Medical center, Chinese People's Liberation Army Hospital, Beijing, China., Beijing, China, 2Philips Healthcare, Beijing, China, Beijing, China |
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Over the past few decades, all-cause mortality and cardiovascular events have remained high in ST-segment elevation myocardial infarction (STEMI) patients. One of the reasons for this is that adverse LV remodeling of the heart that occurs in many patients after myocardial infarction. Cardiac magnetic resonance (CMR) imaging has become a beneficial imaging modality to assess myocardial morphology, LV function and infarct characteristics simultaneously. This study analyzed the value of LV volumes, LV function and infarct characteristics by CMR predicting adverse LV remodeling after STEMI. Our data showed that total enhanced volume was the most accurate prediction parameter. |
| 4120 | Booth 5
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Left ventricular myocardial motion and fibrosis in patients with repaired tetralogy of Fallot |
| Hung-Wei Wei Wang1, Ming-Ting Wu2, Ken-Pen Weng3,4, and Hsu-Hsia Peng5 | ||
1National Tsing Hua University, Hsinchu, Taiwan, 2Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 3Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 4Department of Pediatrics, National Yang-Ming University, Taipei, Taiwan, 5Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan |
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Repaired tetralogy of Fallot (rTOF) caused diffuse fibrosis due to adverse ventricular reconstruction. T1 mapping was employed to observe the diffuse fibrosis. In patients, the native T1 and peak diastolic longitudinal velocity (Vz) were found to be different from the normal group. We aimed to investigate the relationship between left ventricular myocardial motion and myocardial fibrosis in patients with rTOF. |
| 4121 | Booth 6
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Motion Correction for Myocardial T1 Mapping using Self-supervised Deep Learning Registration with Contrast Separation |
| Yuze Li1, Chunyan Wu1, Haikun Qi2, Dongyue Si1, Haiyan Ding1, and Huijun Chen1 | ||
1Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing, China, 2School of Biomedical Engineering, ShanghaiTech University, Shanghai, China |
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A motion correction method for myocardial T1 mapping using Self-supervised Deep learning based Registration with contrAst seParation (SDRAP) was proposed. A sparse coding based method was firstly proposed to separate the contrast component from T1w images. Then, a self-supervised deep neural network was developed to register contrast separated images, followed by the signal fitting to generate motion corrected T1 maps. Models were trained and tested in 47 healthy volunteers using MOLLI sequence, and compared with Free Form Deformation method. Results showed the proposed method can achieve better performance in registration and T1 mapping with higher efficiency (7x acceleration). |
| 4122 | Booth 7
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Relationship between Infarct size, strain and infarct site in patients with ST-segment elevation myocardial infarction |
| Jianing Cui1, Tao Li1, Yanan Zhao1, Wei Wang1, Wenjia Liu1, Yundai Chen2, Geng Qian2, Xiuzheng Yue3, and Yishi Wang3 | ||
1Department of Radiology, the First Medical center, Chinese People's Liberation Army Hospital, Beijing, China., Beijing, China, 2Department of Cardiology, The Six Medical Center, Chinese People's Liberation Army Hospital , Beijing, China., Beijing, China, 3Philips Healthcare, Beijing, China, Beijing, China |
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Effective risk assessment and stratification are essential for the clinical management of ST-segment elevation myocardial infarction (STEMI) patients. CMR imaging has become a beneficial imaging modality to assess myocardial morphology, function and infarct characteristics simultaneously. This study quantitatively evaluated the relationship between infarct size, regional myocardial function by cardiac magnetic resonance feature tracking strain analysis and infarct location in patients with STEMI treated by primary percutaneous coronary intervention. Our data showed that myocardial damage was more extensive and regional myocardial function in infarct zone was lower in the anterior wall myocardial infarction group compared to non-anterior wall myocardial infarction group. |
| 4123 | Booth 8
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Convolutional neural networks to differentiate hypertrophic cardiomyopathy from hypertensive heart disease based on cardiac cine imaging |
| Qiming Liu1, Yezi Chai1, Meng Jiang1, and Chenxi Hu2 | ||
1Department of Cardiology, Ren Ji Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2Institute of Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, shanghai, China |
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Differentiating hypertrophic cardiomyopathy (HCM) from hypertensive heart disease (HHD) is important yet challenging. In this study, we compared 9 convolutional neural network (CNN) models based on cardiac MR cine imaging only for differentiation of the two diseases. We show that the dynamic information contained in cine about myocardial contraction and relaxation is crucial for accurate differentiation. By leveraging this information, we achieved a testing accuracy of 86.8% ± 3.5% in a cohort including 190 HCM and 113 HHD subjects. The results show that cine-based CNN is reasonably accurate for differentiation of HCM and HHD. |
| 4124 | Booth 9
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Deep learning based whole heart T2-weighted dark blood imaging in a single breath hold |
| Xianghu Yan1, Lu Huang1, Lingping Ran1, Yi Luo1, Yuwei Bao1, Shuheng Zhang2, Shiyu Zhang2, Yongquan Ye3, Jian Xu3, and Liming Xia1 | ||
1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2United Imaging Healthcare, Shanghai, China, 3UIH America, Inc., Houston, TX, United States |
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Cardiovascular magnetic resonance (CMR) T2-weighted dark blood (T2W-DB) imaging has great diagnostic value for detecting myocardial edema. In this study, a novel deep learning based acceleration framework (AI-assisted Compressed Sensing, ACS) was applied to a single-shot T2W-DB sequence for single breath-hold whole heart (9 slices) imaging. Both quantitative and qualitative assessment of the images suggested that the ACS T2-DB sequence offered better image quality with greatly reduced total scan time and the simplified scanning workflow. |
| 4125
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Booth 10
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Real-time free-running cardiac imaging with ultra-fast reconstruction technique |
| Zhongsen Li1, Hanyu Wei1, Shuo Chen1, Chuyu Liu1, Mingzhu Fu1, Wei Qiu1, Shuai Wang1, Haining Wei1, Haozhong Sun1, Xihai Zhao1, and Rui Li1 | ||
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China |
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In this study we have realized a real-time free-running cardiac imaging technique which can provide a continuous high-temporal-resolution movie of the heart during the whole acquisition process. This technique is based on the constrained partial separable model, which has been elaborately designed and optimized to achieve maximum reconstruction speed. Over two thousands dynamic frames of the heart can be acquired and reconstructed in just only 1 minute, without any ECG or respiratory monitoring devices needed. This technique has great potential for the cardiac imaging for patients with arrhythmia. |
| 4126 | Booth 11
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The feasibility of cardiac magnetic resonance myocardial feature tracking in evaluating patients with atrial fibrillation |
| Jianhui Li1, Yanzhen Liu1, Yanhe Ma1, Anhong Yu1, Yapeng Yang1, Jiwei Sun1, Jianxiu Lian2, and Hong Zhang1 | ||
1Department of Radiology, Tianjin Chest Hospital, Tianjin, China, 2Philips Healthcare, Beijing, China |
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Atrial fibrillation increases mortality and is an independent risk factor for heart failure and stroke. Cardiac magnetic resonance feature tracking (CMR-FT) is a post-processing technique that can quantitatively assess myocardial deformation. The result showed that patients with Atrial fibrillation had lower left ventricle longitudinal strain (LVLS) and left atrial longitudinal strain（LALS）compared with healthy control，which may due to impaired function and myocardial injury. Therefore, measuring the longitudinal strain of the left atrium and left ventricle can be used as an important method to evaluate the function of patients with atrial fibrillation. |
| 4127 | Booth 12
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T1ρ dispersion imaging on 3T MRI detects diffuse fibrosis in subtypes of hypertrophic cardiomyopathy |
| Keyan Wang1, Wenbo Zhang1, Shuman Li1, Hongrui Jin1, Yanan Jin1, Yanan Jin1, Li Wang2, Ran Li3, Yang Yang4, Jingliang Cheng1, Jie Zheng5, and Jing An6 | ||
1MRI department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2Pathology department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 3Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, United States, 4Icahn School of Medicine at Mount Sinai, New York, NY, United States, 5Washington University School of Medicine, Saint Louis, MO, United States, 6Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China |
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This study evaluated a cardiac T1ρdispersion mapping technique, termed as myocardial fibrosis index (mFI), to distinguish various levels of fibrosis in different subtypes of hypertrophic cardiomyopathy (HCM). These subtypes included patients with or without obstructive HCM, and with or without hypertrophic myocardial segments. Our data demonstrated that the mFI is equal to or significantly better than other cardiac fibrosis index, contrast-derived extracellular volumes, and native T1 values. |
| 4128 | Booth 13
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Co-registration of cardiac PET and late gadolinium enhancement MRI for integrated PET/MR |
| zheng zhang1,2, Xing Chen3, Zhiwen You3, Jianmin Yuan2, Lingzhi hu4, Jun Zhao3, and Chenxi Hu1 | ||
1Shanghai Jiao Tong University, Shanghai, China, 2United Imaging Healthcare Co. Ltd., Shanghai, China, 3Shanghai East Hospital, Shanghai, China, 4United Imaging Healthcare Co. Ltd., Houston, TX, United States |
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A two-stage cardiac PET/late gadolinium enhancement (LGE) co-registration method proposed here significantly improved the co-registration between PET and LGE in integrated PET/MR imaging. The two-stage method led to increased registration score (4.93±0.89) versus no-registration (3.49±0.84, p<0.001) and a single-stage method (4.23±0.81, p<0.001), an increased SUV value in the normal myocardium (3.87±2.56) compared with the no-registration (3.14±1.92, p<0.001) and the single-stage method (3.32±2.16, p<0.001). The technique may improve diagnostic accuracy of non-ischemic cardiomyopathies via better image co-registration. |
| 4129 | Booth 14
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The Reliability of CMR Fast Late Gadolinium Enhancement Sequence in The Evaluation of Patients with Acute Myocardial Infarction |
| li jinshui1 and he yi1 | ||
1Beijing Friendship Hospital, bei jing, China |
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By comparing the three kinds of LGE images of 110 patients with AMI, and taking the current standard turbo FLASH imaging sequence as reference, this study verified the accuracy of using moco bSSFP and TrueFISP to evaluate the lesions in patients with AMI. The research covers image quality evaluation and qualitative diagnosis accuracy evaluation. The results show that moco bSSFP sequence and TrueFISP sequence have equivalent effect as turbo FLASH sequence in the qualitative diagnosis, but their image quality is better than that of turbo FLASH sequence. |
| 4130 | Booth 1
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FLEXA 3DTOF: Fast 3D TOF MR Angiography using Thin-slab Two-Point Dixon Acquisition |
| Naoyuki Takei1, Shiori Amemiya2, Tsuyoshi Ueyama3, Keita Fujii3, Osamu Abe2, and Tetsuya Wakayama1 | ||
1GE Healthcare, Tokyo, Japan, 2Radiology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, 3Radiology, The University of Tokyo Hospital, Tokyo, Japan |
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Conventional 3DTOF MOTSA MRA technique without contrast agent is an established technique for carotid artery examination. The scan time is relatively long to have opportunity to improve. We have explored 3DTOF with two-point Dixon acquisition to achieve faster scan time by optimizing scan parameters and dealing with Water-Fat swap issue where B0 inhomogeneity and strong susceptibility exist at off-center scan in multi-slab acquisitions. The proposed Dixon MRA offers an alternative approach to conventional 3DTOF with about 4.2 times faster acquisition and better image contrast between artery and muscle for carotid MRA. |
| 4131 | Booth 2
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Evaluation of Coronary Artery Damage in Kawasaki Disease with Non-Contrast Whole-Heart Coronary Magnetic Resonance Angiography |
| Yurong Ma1, Juan Liang1, Na Han1, Kai Ai2, and Jing Zhang1 | ||
1Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China, 2Philips healthcare, Xi'an, China |
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In this study, the non-contrast whole-heart coronary magnetic resonance angiography (NCE-CMRA) is used to evaluate the coronary artery damage in Kawasaki Disease (KD). The NCE-CMRA and ultrasound images of children with Kawasaki disease (KD) are retrospectively analyzed. Compared with echocardiography, the NCE-CMRA has its unique advantages in displaying coronary artery, such as high image resolution, good soft tissue contrast and strong signal to noise ratio. Furthermore, NCE-CMRA can clearly and directly show the damaged coronary artery. Therefore, it is a potential alternative to ultrasound for imaging of the coronary artery in children with KD. |
| 4132 | Booth 3
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PANDA: Simultaneous Phase-Contrast Bright and Dark-blood Angiography for Improvement of Carotid Plaque Assessment |
| Daichi Murayama1, Takayuki Sakai1, Masami Yoneyama2, Jihun Kwon2, and Shigehiro Ochi1 | ||
1Department of Radiology, Eastern Chiba Medical Center, Chiba, Japan, 2Philips Japan, Tokyo, Japan |
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TOF-MRA sometimes cannot delineate the vessel clearly depending on the vessel orientation. Additionally, insufficient fat suppression can occur in FS-T1-VISTA, it may obscure the plaque depiction. we have developed a new sequence, termed Phase-contrast ANgiography with Dark-blood Application (PANDA), which can simultaneously acquire bright-blood image (MRA) and vessel-wall images (VWI) using the phase contrast method. There was no difference in the visualization ability of carotid plaque between PANDA-VWI and FS T1 VISTA. PANDA-MRA better visualized around the aorta compared to TOF-MRA. PANDA is useful method for simultaneous acquisition of MRA and VWI images. |
| 4133 | Booth 4
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High resolution retinal blood flow MRI using a new acquisition strategy for MRI of curved objects |
| Eric R. Muir1 | ||
1Radiology, Stony Brook University, Stony Brook, NY, United States |
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The retina has highly structured laminar organization, with two separate blood supplies, the retinal and the choroidal blood flow layers. Retinal MRI has generally used a single thick 2D slice. Extension to 3D retinal MRI is difficult due to the curvature of the eye and limited SNR at the needed high resolution. A new acquisition strategy for MRI of curved objects was developed, in which high-resolution is acquired perpendicular to the retina but with low-resolution tangent to the retina. This approach gave significant gains in SNR and provided laminar resolution of the retinal and choroidal blood flow in 3D. |
| 4134 | Booth 5
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Comparative analysis of the imaging quality in magnetic resonance coronary angiography with 3D mDIXON and B-TFE sequence on 3T |
| Gang Zhang1, Wei Xing2, Tingting Li2, Yan Zheng1, Ying Huang2, Junjing He2, and Xiuzheng Yue3 | ||
1The First Affiliated Hospital of Henan University of CM, Zhengzhou, China, 2Department of Magnetic Resonance, The First Affiliated Hospital of Henan University of CM, Zhengzhou, China, 3Department of Magnetic Resonance, Philips Healthcare, Zhengzhou, China |
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Due to the narrow diameter, tortuous route of coronary arteries, and the interference of respiration and heartbeats during scanning, MR coronary angiography (MRCA) remains challenge. In 3.0T MR systems, an improved 3D Balanced Turbo Field Echo (B-TFE) sequence is often used for MRCA[1,2], however, 3D mDIXON sequences have been applied for clinical application recently.[3,4] In this study, the subjective imaging quality, objective imaging quality and image authenticity indexes of MRCA with two imaging sequences were compared to analysis. Results showed that B-TFE had better subjective evaluation than mDixon, but mDIXON had better objective quality evaluation for SNR and CNR. |
| 4135 | Booth 6
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Introduction of the Right Ventricular-Arterial Coupling Index in CMR Reflecting Lung Histological Changes in Experimental PAH |
| Ali Nahardani1,2, Katja Grün3, Martin Krämer2, Karl-Heinz Herrmann2, Andrea Schrepper4, Sara Moradi1, Jürgen R. Reichenbach2, Marcus Franz3, and Verena Hoerr1,2,5 | ||
1Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, Bonn, Germany, 2Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany, 3Department of Internal Medicine I, Division of Cardiology, Angiology, Pneumology, and Intensive Medical Care, Jena University Hospital, Jena, Germany, 4Department of Cardiothoracic Surgery, Jena University Hospital, Jena, Germany, 5Translational Research Imaging Center (TRIC), Clinic for Radiology, University Hospital Muenster, Muenster, Germany |
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The current preclinical study aims to investigate the associativity between the ventricular-arterial coupling index (VAC) derived by CMR and microscopic vascular changes in pulmonary arterial hypertension (PAH). To this end, three stages of disease were incorporated in the study: healthy, moderate, and severe. All animals underwent CMR and echocardiography. The corresponding lung tissue was also assessed histologically. The right VAC could predict the presence of histopathological changes with r=-0.95 and had a strong correlation with tricuspid annular plane systolic excursion (r=0.90). |
| 4136 | Booth 7
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The application of REACT for central veins in patients with end-stage renal disease |
| Fengming Tao1, Li Tao1, Wei Zhu1, Fajin Lv1, Yongmei Li1, Haitao YANG1, Zhiwei Zhang1, and Ke Jiang2 | ||
1The first affiliated hospital of Chongqing medical university, Chongqing, China, 2Philips Healthcare, Beijing, China |
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Relaxation-Enhanced Angiography without Contrast and Triggering (REACT) is a MR angiography technique without cardiac triggering, breath holding and contrast agent injection and is able to show robust blood-to-tissue contrast over multiple anatomies. This study aims to investigate the feasibility of REACT on central veins by comparing it with conventional CE-MRA and catheter angiography. Results showed that the image quality acquired from REACT was comparable to that from CE-MRA and there was no difference in central venous stenosis evaluated by REACT, CE-MRA and angiography. |
| 4137 | Booth 8
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iZoom with 2nd order flow compensated diffusion for Improving cardiac diffusion imaging: a preliminary study |
| Zhigang Wu1, Yajing Zhang2, Xiuquan Hu1, Jing Zhang1, Fei Zeng1, Xiaofang Xu1, Guangyu Jiang3, Yan Zhao3, Guillaume Gilbert4, and Jiazheng Wang1 | ||
1Philips Healthcare, Beijing, China, 2MR Clinical Science, Philips Healthcare (Suzhou), Suzhou, China, 3MR R&D, Philips Healthcare (Suzhou), Suzhou, China, 4Philips Healthcare, Precision Diagnosis, Hillmount, ON, Canada |
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Diffusion MRI could provide unique information non-invasively. However, it is still a technical challenge due to the intrinsic non-rigid motion during the cardiac cycle, displacement of the myocardium due to respiratory motion, field inhomogeneity, and short T1 and T2 values. Parallel imaging and Zoom imaging based on 2D RF (iZoom) could both reduce the distortion dramatically, second order flow compensated diffusion could be used to decrease the impact of motion. We propose a solution that combines iZoom, SENSE and the 2nd flow compensated diffusion to generate a robust cardiac diffusion MRI, its robustness was validated by a preliminary study. |
| 4138 | Booth 9
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High resolution Isotropic 3D Black Blood Thoracic Aorta Imaging With Low Rank Patch-Based Reconstruction |
| caiyun shi1,2, yuanyuan liu1, guanxu cheng3, yulong qi3, haifeng wang1, lei zhang1, xin liu1, hairong zheng1, dong liang1, and yanjie zhu1 | ||
1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, shenzhen, China, 2Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, shenzhen, China, 3Peking University Shenzhen Hospital, shenzhen, China |
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Three-dimensional (3D) black-blood MRI is a promising noninvasive imaging technique for assessing aortic atherosclerotic plaque. In this work, a low rank patch-based technique is proposed, and combined with a 3D modulated vFA-FSE sequence for high-resolution thoracic aorta imaging. The comparison was conducted on healthy volunteers and compared against a conventional GRAPPA acquisition to assess the feasibility of the proposed scheme. The results showed the reconstruction scheme was able to visualize the lumen areas clearly and improve the vessel sharpness and contrast ratio significantly. |
| 4139 | Booth 10
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Sub-aortic Complex is a Simple and Accurate Parameter to Predict Obstruction in Hypertrophic Cardiomyopathy: A CMR and Doppler Study |
| Zixian Chen1, Junqiang Lei1, Shunlin Guo2, Zheng Zhang3, Shihua Zhao4, and Minjie Lu4 | ||
1Department of Radiology, The First Hospital of Lanzhou University, Intelligent Imaging Medical Engineering Research Center of Gansu Province, Accurate Image Collaborative Innovation International Science and Technology Cooperation Base of Gansu Province, Radiological Clinical Medicine Research Center of Gansu Province, Lanzhou, China, 2Radiology, The First Hospital of Lanzhou University, Intelligent Imaging Medical Engineering Research Center of Gansu Province, Accurate Image Collaborative Innovation International Science and Technology Cooperation Base of Gansu Province, Radiological Clinical Medicine Research Center of Gansu Province, Lanzhou, China, 3Department of Cardiology, The first Hospital of Lanzhou University, Lanzhou, China, 4Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease，Fuwai Hospital, National Center for Cardiovascular Diseases，Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China |
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To investigate the “sub-aortic complex (SAC)”, a new cardiac magnetic resonance (CMR) derived parameter, for the detection and grading of left ventricular outflow tract (LVOT) obstruction in hypertrophic cardiomyopathy (HCM) patients, compared with echocardiography and CMR 2D flow. |
| 4140 | Booth 11
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Assessment of myocardial microstructural change using novel motion compensated technique in cardiac diffusion tensor imaging |
| Wataru Ueki1, Yoshiaki Morita1, Yu Ueda2, Masaru Shiotani1, Tatsuhiro Yamamoto1, Yasuhiro Nagai1, Yasutoshi Ohta1, Keizo Murakawa1, and Tetsuya Fukuda1 | ||
1National Cerebral and Cardiovascular Center, Suita, Japan, 2Philips Japan Ltd, Tokyo, Japan |
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The accelerated motion compensation (aMC) using higher order motion compensated gradients with asymmetric bipolar diffusion waveform can improve the image quality of cardiac DTI compared with conventional method and provide the relatively constant DTI marker. In LVH patients, aMC-DTI derived possible preliminary insights into detection of abnormal changes in myocardial microstructures in-vivo, even in segments without LGE. |
| 4141 | Booth 1
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Fast High-Resolution 3D MRSI and T2 Mapping for Clinical Outcome Prediction of Ischemic Stroke Patients |
| Ziyu Meng1, Tianyao Wang2, Bin Bo1, Rong Guo3,4, Yudu Li3,4, Yibo Zhao3,4, Xin Yu5, Zhi-Pei Liang3,4, and Yao Li1 | ||
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Radiology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, 3Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 5Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States |
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Characterization of the underlying pathophysiological changes associated with edema progression is essential for treatment guidance in ischemic stroke. 1H-MRSI and quantitative T2 mapping can acquire image markers related to the physiological states of brain tissues. This study investigated the neurometabolite changes in relation to the development of vasogenic edema in ischemic stroke patients, using fast high-resolution 3D MRSI and T2 mapping techniques. Our results showed that neurometabolite concentrations were strongly correlated with T2 values within ischemic lesion of stroke patients and integrated T2 and neurometabolite biomarkers improved the prediction accuracy of stroke patients' clinical outcome. |
| 4142 | Booth 2
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0.2 mm Isotropic Intracranial Perforating Arteries Imaging using Compressed Sensing TOF-MRA at 7T |
| Zhe Zhang1,2, Qingle Kong3, Jing Jing1,2, and Yongjun Wang1,2,4 | ||
1Tiantan Neuroimaging Center of Excellence, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 2China National Clinical Research Center for Neurological Diseases, Beijing, China, 3MR Collaboration, Siemens Healthineers Ltd., Beijing, China, 4Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China |
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The impairment of microvessels can lead to neurologic diseases such as stroke and vascular dementia. The imaging of perforating arteries requires an extremely high resolution due to their small caliber size. In this study, we optimized the parameters of compressed sensing (CS) TOF-MRA to achieve isotropic 0.2 mm lenticulostriate artery (LSA) images within 10 minutes at 7T. More LSA stems and branches were delineated in CS TOF images compared with conventional TOF images. CS TOF-MRA can be a state-of-the-art method for detecting microvasculopathies of cerebral vascular diseases. |
| 4143 | Booth 3
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Non-Contrast Time-Resolved MR Angiography with Consecutive Beam Pulse with Variable Saturation Flip Angle |
| Hirohito Kan1,2, Kyosuke Mizuno3, Masahiro Takizawa4, Masashi Shimohira5, Tatsuya Kawai5, Tositaka Aoki6, Satoshi Tsubokura6, and Harumasa Kasai6 | ||
1Department of Integrated Health Scieneces, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, 3Department of Radiology, Nagoya City University Hospital, Nagoya, Japan, 4FUJIFILM Healthcare Corp., Tokyo, Japan, 5Department of Radiology, Nagoya City University Graduate School of Medical Scieneces, Nagoya, Japan, 6Nagoya City University Hospital, Nagoya, Japan |
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To develop and validate the non-contrast time-resolved MR angiography (NC TR-MRA) with consecutive beam pulse with variable saturation flip angle method, we performed a phantom study using steady flow and the volunteer study targeted to the pulmonary artery. The length of visualized flow signals was exhibited proportional to the number of beam saturation pulses in the phantom study. In human study, the visualization range of the pulmonary artery was also extended with increasing the number of beam pulses. The novel consecutive beam pulse with variable saturation flip angle method can depict blood vessels in each flow phase. |
| 4144 | Booth 4
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Vulnerable plaque characteristics on MR vessel wall imaging predict hemodynamic instability during carotid artery stenting |
| Qi Meng1, Chao Jiang2, Keqiang Zhao2, Huabin Zhang1, Hongliang Zhao3, Xihai Zhao4, Weiwei Wu2, and Zhuozhao Zheng3 | ||
1Department of Ultrasound, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China, 2Department of Vascular Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China, 3Department of Radiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China, 4Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China |
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It has been shown that about 30%-70% of the patients underwent carotid artery stenting (CAS) suffered from perioperative hemodynamic instability (HI) characterized by transient hypotension and bradycardia. This study investigated the association between vulnerable plaque characteristics on MR vessel wall imaging and HI during CAS. We found that patients in HI group had significantly larger wall area and total vessel area, higher prevalence of intraplaque hemorrhage and vulnerable plaque, and larger volume of lipid-rich necrotic core (LRNC) of carotid plaque compared to those in non-HI group. The volume of LRNC and presence of vulnerable plaque could effectively predict HI. |
| 4145 | Booth 5
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Rapid high-resolution mapping of cerebral blood flow and volume by dynamic BOLD MRI with transient hypoxia in mice |
| Dongkyu Lee1, Thi Thuy Le1, Geun Ho Im1, and Seong-Gi Kim1 | ||
1Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of |
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Noninvasive perfusion mapping is important to determine perfusion changes due to molecular and neuropathological modifications as well as pharmaceutical interventions. Here, we adopted a dynamic BOLD-MRI method for quantifying whole brain perfusion, such as cerebral blood volume (CBV) and cerebral blood flow (CBF) without the use of exogenous contrast agents in mice. High-resolution perfusion maps allow us to determine regional perfusion values and cortical depth-dependency. The proposed technique is non-invasive and repeatable with every <1 min temporal resolution and can combine with evoked fMRI studies for determining a neural activity-induced quantitative change of perfusion parameters. |
| 4146 | Booth 6
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Single-breath-hold whole heart coronary MRA using 3D turbo-field-echo-planar-imaging (TFEPI) with Compressed SENSE framework |
| Kazuo Kodaira1, Michinobu Nagao2, Masami Yoneyama3, Mana Kato1, Takumi Ogawa1, Yutaka Hamatani1, Isao Shiina1, Yasuhiro Goto1, and Shuji Sakai2 | ||
1Department of Radiological Services, Tokyo Woman's Medical University Hospital, Tokyo, Japan, 2Department of Diagnostic imaging & Nuclear Medicine, Tokyo Woman's Medical University Hospital, Tokyo, Japan, 3Philips Japan, Tokyo, Japan |
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Conventional whole-heart-coronary-magnetic-resonance-angiography (WHC-MRA) using NAV has a limitation of long scan time. Single-breath-hold-multi-shot-gradient-EPI can significantly reduce scan time of WHC-MRA, but it may be difficult depending on the gradient-spec of MRI-system. 3D-turbo-field-echo-planar-imaging (TFEPI) with Compressed-SENSE (C-SENSE) has the possibility to solve these problems. However, it is yet not applied for WHC-MRA. C-SENSE is suitable for subjects with a high sparse such as vessels, and can accelerate scan time of WHC-MRA while ensuring image quality. We propose a new combination of TFEPI with C-SENSE for single-breath-hold WHC-MRA, and examine image quality and scan time in comparison to the conventional methods. |
| 4147 | Booth 7
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The impact factors of the Quality of non-contrast agent Coronary angiography at 3.0T Magnetic Resonance |
| Junjing He1, Xiuzheng Yue2, Gang Zhang1, Wei Xing1, Tingting Li1, Yufu Hu1, and Yuhan Wang1 | ||
1Department of Magnetic Resonance, The First Affiliated Hospital of Henan University of CM, Zhengzhou, China, 2Philips Healthcare, Beijing, China |
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This study explores impact factors of the quality of 3.0T non-contrast agent magnetic resonance coronary angiography (MRCA), and uses an objective standard for assessing the image quality. A retrospective review was conducted on 72 patients who successfully completed 3.0T MRCA, and the correlation between their image quality and their clinical data, scan sequence, parameter settings, imaging technology and other factors were analyzed.The study found that BMI and respiratory motion were the key factors that affect the quality of non- contrast agent coronary MRA on 3.0T MRI. The mDixon-TFE imaging method can be used for MRCA as a routine scanning sequence. |
| 4148 | Booth 8
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The application of whole-heart coronary MRA with compressed sensing in patients with atrial fibrillation |
| FENG XIONG1, Yang Wu1, Longyan Zhang1, Xiaojing Ma1, Ke Yu1, Peng Sun2, and Haixia LI2 | ||
1Wuhan Asia General Hospital, WuHan, China, 2Philips Healthcare, Beijing, China |
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The whole-heart coronary MRA with compressed sensing (CS) technique is a novelly noninvasive, contrast agent-free, and radiation-free technique for evaluating coronary artery disease[2] [3].Patients with atrial fibrillation have irregular heartbeat, which brings uncertainty to the coronary MRA image quality. Results of this study indicated that there was no statistical difference in coronary artery image quality with CS acceleration factors of 2, 4, 6 between sinus rhythm and atrial fibrillation patients, which suggested that whole-heart coronary MRA with CS technique could also be applied inpatients with atrial fibrillation. |
| 4149 | Booth 9
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Comparison of the Accuracy between High-resolution B-TFE and 3D T1-FFE MR Sequences on Human Spinal Artery Lesions |
| Yunjie Liao1 and Chen Thomas Zhao2 | ||
1Department of Radiology, the Third Xiangya Hospital, Central South University, Changsha, China, 2Philips Healthcare, Guangzhou, China |
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Spinal artery imaging has long been difficult in clinical detection and assessment of spinal vascular lesions, due to its anatomical complexity and very small diameter. Compared with DSA and CT, CE-MRA technology has the advantages of safety, noninvasive and radiation free. Traditional MR sequences, such as TOF and PC, perform poorly with lower SNR. Here, accuracy of B-TFE and 3D T1-FFE sequences were compared to provide radiologists a better choice in the spinal artery scenario. The results indicated that 3D T1-FFE would be preferred than B-TFE. And B-TFE should be used merely when patients are sensitive to contrast media |
| 4150 | Booth 10
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Can HR-VW-MRI effectively evaluate the treatment effect on patients with MCA atherosclerotic stenosis after recanalization? |
| Kunjian Chen1, Weiqiang Dou2, Xinyi Wang1, Huimin Mao1, and Yu Guo1 | ||
1Department of Radiology, The First Affiliated Hospital of Shandong First Medical University, Jinan, China, 2MR Research, GE Healthcare, Beijing, China |
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This study mainly explored the feasibility of high-resolution vascular wall magnetic resonance imaging（HR-VW-MRI）in evaluating the treatment effect for patient with middle cerebral artery (MCA) recanalization. We included 21 patients with MCA stenosis diagnosed by DSA. All patients were treated with SeQuent Please drug-coated balloon recanalization and performed with HR-VW-MRI examination. Decreased responsible plaque area, length, enhancement index and lumen stenosis degree were found in MCA postoperatively. Additionally, the lumen stenosis degree evaluated by HR-VW-MRI was highly correlated with DSA. Therefore, HR-VW-MRI could be used as a valuable method to diagnose the effect of vascular recanalization. |
| 4151 | Booth 11
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Middle Cerebral Artery Morphologies Associated with White Matter Hyperintensities |
| Boyu Zhang1, Zidong Yang1, Bei Wang1, Yajing Huo2, Huihui Lv2, Zhensen Chen1, Yan Han2, and He Wang1,3 | ||
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 2Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China, 3Human Phenome Institute, Fudan University, Shanghai, China |
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The current report summarizes the morphological characteristics of middle cerebral artery quantified from MRA scans in a large sample of older Chinese population and shows that higher M1 radius is an independent predictor of white matter hyperintensities (WMH). Furthermore, as the pathological changes resulting in white matter lesions are heterogeneous, the current study suggest that the spatial distribution patterns of WMH could reflect the underpinning pathological mechanisms, though further studies are required. |
| 4152
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Booth 12
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Microstructural alterations in projection and association fibers in neonatal hypoxia-ischemia |
| Zuozhen Cao1, Xiaoxia Shen2, Fusheng Gao3, Tingting Liu1, Zhiyong Zhao1, Hongxi Zhang3, Lizhong Du2, Jiangyang Zhang4, Yi Zhang1, Can Lai3, Xiaolu Ma2, and Dan Wu1 | ||
1College of Biomedical Engineering & Instrument Science, Zhejiang University, HangZhou, China, 2Department of Neonatal Intensive Care Unit, Children's Hospital affiliated to Zhejiang University School of Medicine, HangZhou, China, 3Department of Radiology, Children's Hospital affiliated to Zhejiang University School of Medicine, HangZhou, China, 4Department of Radiology, New York University School of Medicine, New York, NY, United States |
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Diffusion MRI (dMRI) is known to be sensitive to hypoxic-ischemic encephalopathy (HIE) , however, the existing dMRI studies only used diffusion tensor metrics in a few selected brain regions and primarily focus on severe-to-moderate HIE. Here we investigated microstructural alterations using multi-shell dMRI across the whole-brain in severe, moderate, and mild HIE babies (n=5/13/13) in comparison with control neonates (n=11) with region-of-interest-based, tract-based, and fixel-based analysis. We found microstructural alternations in projection and association fibers, especially the inferior fronto-occipital fasciculus and inferior longitudinal fasciculus that are important for visual functions. |
| 4153 | Booth 13
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Application of Electric Properties Tomography to Ischemic Stroke: Comparison of Conductivity between Infarct and Contralateral Brain |
| Onila Rasanjala1, Nguyen Trong Nguyen 2, Joohyun Kim3, Eunju Kim3, Ulrich Katscher4, Byung Hyun Baek5, and Ilwoo Park1,5 | ||
1Department of Artificial Intelligence Convergence, Chonnam National University, Gwangju, Korea, Republic of, 2Department of Biomedical Science, Chonnam National University, Gwangju, Korea, Republic of, 3Philips Korea, Seoul, Korea, Republic of, 4Philips Research Laboratories, Hamburg, Germany, 5Department of Radiology, Chonnam National University, Gwangju, Korea, Republic of |
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We demonstrate the feasibility of obtaining conductivity using EPT from patients with stroke. The ischemic lesion exhibited significantly higher conductivity values than the contralateral brain tissue in the cerebral brain, while the pons and cerebellum showed similar levels of conductivity values between the ischemic lesion and the contralateral brain tissue. The levels of conductivity value appeared to be specific to regions. The infratentorial normal brain exhibited a significantly higher level of conductivity than the supratentorial brain. In addition, the levels of conductivity were significantly different between the ischemic lesions of basal ganglia & thalamus and cerebral hemisphere. |
| 4154 | Booth 14
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Reduced coupling between global blood-oxygen-level-dependent signal and cerebrospinal fluid inflow is related to small vessel disease |
| Yao Zhang1, Ruiting Zhang1, Minming Zhang1, Yong Zhang2, and Peiyu Huang1 | ||
1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, 2GE Healthcare, Shanghai, China |
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The association between the glymphatic dysfunction and cerebral small vessel disease (SVD) is still unclear due a lack of in vivo measures. In this work, we employed a novel method based on the coupling between global blood-oxygen-level-dependent (gBOLD) signal and cerebrospinal fluid (CSF) inflow, which could detect alterations in CSF dynamics. We found that patients with severe SVD had significantly impaired glymphatic function. The dilation of peri-vascular space and the presence of diabetes were associated with worse glymphatic function. These results may provide useful knowledge for understanding the mechanism of SVD and improving clinical treatment. |
| 4155 | Booth 15
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Weakly-Supervised Carotid Vessel Wall Sub-pixel Segmentation Using Global-Local Context Aggregation and PolarMask |
| Jiaqi Dou1, Song Tian2, Yuze Li1, Ziming Xu1, Shuo Chen1, Yajie Wang1, and Huijun Chen1 | ||
1Center for Biomedical Imaging Research, Tsinghua University, Beijing, China, 2MSC Clinical & Technical Solutions, Philips Healthcare, Beijing, China |
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Carotid vessel wall segmentation on 3D black-blood MRI is a key step in plaque burden assessment and atherosclerotic lesions identification. In this study, a two-stage weakly-supervised carotid vessel wall segmentation approach was developed using limited manual delineations on 3D black-blood MR images. First, a global-local context aggregation strategy was used to identify bilateral carotid arteries robustly. Then, distances from artery center to boundaries were regressed in a polar coordinate by PolarMask to segment the vessel wall. The proposed segmentation approach outperformed Attention UNet (Quantitative score: 0.795±0.170 vs. 0.729±0.208) and showed great potential in quantitative atherosclerosis analysis. |
| 4156 | Booth 1
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Assessment of myocardial involvement in patients with Fabry disease using metabolic imaging by 1H-MR Spectroscopy (1H-MRS) |
| Masaru Shiotani1, Yoshiaki Morita1, Yoshito Ichiba2, Yasuhiro Nagai1, Wataru Ueki1, Tatsuhiro Yamamoto1, Yasutoshi Ohta1, Keizo Murakawa1, and Tetsuya Fukuda1 | ||
1Department of Radiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan, 2MR Research & CollaborationDpt. Diagnostic Imaging Division, Siemens Healthcare K.K., Shinagawa-ku, Tokyo, Japan |
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The peak ratio of 3.5ppm to water in 1H-MRS of myocardium showed the higher values in Fabry disease and the association with native T1 values and regional function. 1H-MRS has a potential as disease-specific imaging biomarker for direct quantification of myocardial sphingolipid accumulation of Fabry disease. |
| 4157 | Booth 2
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The feasibility of radiomic analysis based on T1 mapping to distinguish between hypertensive heart disease and hypertrophic cardiomyopathy |
| Shengliang Liu1, Jianxiu Lian2, Haixia Li2, Guokun Wang1, Yunling Li1, Yanming Zhao1, Bing Xu1, and Bo Yu1 | ||
1Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China, 2Philips Healthcare, Beijing, China |
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Hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD) share similar features, such as thickened left ventricular (LV) wall and reduced compliance, which make it difficult to distinguish HCM from HHD clinically. In this retrospective study, patients with HCM and HHD were enrolled to evaluate the feasibility of radiomic analysis to differentiate between these two diseases. For all calculated texture analysis (TA) features, AUCs of nine parameters had the values above 0.65, Logarithm_glszm_ZoneEntropy reached the best performance than other parameters (AUC: 0.790, sensitivity: 71.4 %, specificity: 81.8 %, P < 0.01). |
| 4158 | Booth 3
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3D free-breathing simultaneous whole heart T1 and T2 mapping based on SAturation Recovery and Variable flip Angle (SAVA) |
| Dongyue Si1, Rui Guo2, Bowei Liu1, Daniel A. Herzka3, and Haiyan Ding1 | ||
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, 2Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States, 3National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States |
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Myocardial T1 and T2 mapping enable quantitative detection of various cardiac diseases. Here we propose a fast 3D free-breathing simultaneous T1 and T2 mapping sequence, which acquires four volumes for joint estimation of T1 and T2. A very small flip angle is used for efficient sampling of the equilibrium longitudinal magnetization. Whole-heart T1 and T2 maps were acquired with high resolution of 1.5×1.5×4mm3 within 5 min in normal human subjects with image quality comparable to conventional 2D methods. |
| 4159 | Booth 4
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Combination of strain with LGE can improve diagnostic ability for differentiation hypertrophic cardiomyopathy from hypertensive heart disease |
| Shengliang Liu1, Jianxiu Lian2, Yunling Li1, Guokun Wang1, Haixia Li2, Xueying Wang1, Yanming Zhao1, Bing Xu1, and Bo Yu1 | ||
1Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China, 2Philips Healthcare, Beijing, China |
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To evaluate the value of left ventricular radial strain (LVRS) and left ventricular circumferential strain (LVCS) in discriminating between hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD) by using cardiac magnetic resonance feature tracking (CMR-FT). HCM patients presented higher values of LVRS and LVCS when compared with HHD patients. And both LVRS and LVCS correlated obviously with left ventricular ejection fraction (LVEF) in HCM patients. Furthermore, the combination of strain with LGE can significantly improve the diagnostic ability for differentiation HCM from HHD (AUC: 0.86; sensitivity: 86.9 %; specificity: 76.3 %). |
| 4160 | Booth 5
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T1 rho mapping and native T1 mapping for endogenous assessment of myocardial fibrosis in hypertrophic cardiomyopathy |
| Gang Yin1, Zhixiang Dong1, Shihua Zhao1, Xiuyu Chen1, Kai Yang1, Ke Jiang2, and Zhigang Wu2 | ||
1Fuwai Hospital, Beijing, China, 2Philips Healthcare, Beijing, China |
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This study is to examine the feasibility of T1 rho and native T1 mapping for endogenous detection of diffuse and focal myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM). Results showed that absolute T1 rho increased progressively and significantly from healthy controls to HCM without LGE and then to HCM with LGE, whereas T1 native increased significantly only from healthy controls to HCM with LGE. Besides, both T1 rho and native T1 had moderate correlation with LGE ratio in severe segments. |
| 4161 | Booth 6
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Characteristics of left atrial strain in hypertrophic cardiomyopathy comorbid HF with preserved EF: evaluation by CMR-feature tracking |
| Shi Rui1, Gao Yue1, Shen Li-ting1, and Yang Zhi-gang1 | ||
1West China hospital of Sichuan University, Chengdu, China |
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The majority of heart failure (HF) in hypertrophic cardiomyopathy (HCM) manifests as a phenotype with preserved left ventricular (LV) ejection fraction, however, the exact contribution of left atrial (LA) phasic function to HF with preserved ejection fraction (HFpEF) in HCM remains unresolved. We designed the study to define the association between LA function and HFpEF in HCM patients using cardiac MRI feature tracking. The result revealed that LA phasic function was severely impaired in HCM patients with HFpEF, whereas LV function was not further impaired compared with non-HF patients. |
| 4162 | Booth 7
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The feasibility of evaluating acute ST-segment elevation myocardial infarction by using diffusion weighted imaging and T2* mapping |
| Shengliang Liu1, Jianxiu Lian2, Ke Jiang2, Guokun Wang1, Yunling Li1, Xueying Wang1, Yanming Zhao1, Bing Xu1, and Bo Yu1 | ||
1Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China, 2Philips Healthcare, Beijing, China |
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Acute myocardial infarction is the result of occlusion of cardiac arteries, which leads to myocardial ischemic injury and even necrosis. Diffusion weighted imaging (DWI) and T2* mapping were performed to investigate the correlation between apparent diffusion coefficient (ADC) and T2* values in ST-segment elevation myocardial infarction (STEMI) patients here. ADC values of infarct regions were higher than those in border regions, remote regions in patients with STEMI, and also higher when compared with control group. Conversely, T2* values showed opposite trend. What’s more, there was a negative correlation between T2* and ADC values (r = 0.-734; P < .001). |
| 4163 | Booth 8
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Regional fat distributions are associated with subclinical right ventricular dysfunction in adults with uncomplicated obesity |
| Jing Liu1, Jing Li2, Huaxia Pu2, Wenzhang He1, Xue Li1, Xiaoyue Zhou3, Nanwei Tong2, and Liqing Peng1 | ||
1Radiology, West China Hospital, Sichuan University, Chengdu, China, 2Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China, 3MR Collaboration, Siemens Healthineers Ltd., Shanghai, China |
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This study evaluated right ventricular (RV) functional changes using cardiac magnetic resonance (CMR) tissue tracking and the association of these changes with fat distributions in obese adults with no clinical signs or comorbidities. The results showed that CMR tissue tracking can detect subclinical RV dysfunction with preserved RV ejection fraction in obese adults. Central obesity, represented by android fat, trunk fat, and the android/gynoid fat mass ratio, had a deleterious effect on RV subclinical dysfunction, whereas peripheral obesity (gynoid fat) might have had a protective effect. These findings could contribute to more precise obesity management in clinical practice. |
| 4164 | Booth 9
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Left ventricular diastolic dysfunction in uncomplicated obesity: evaluated by CMR tissue tracking and volume-time curve |
| Jing Liu1, Jing Li2, Huaxia Pu1, Wenzhang He1, Xue Li1, Xiaoyue Zhou3, Nanwei Tong2, and Liqing Peng1 | ||
1Radiology, West China Hospital, Sichuan University, Chengdu, China, 2Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China, 3MR Collaboration, Siemens Healthineers Ltd., Shanghai, China |
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This study evaluated left ventricular (LV) diastolic functional changes and left atrial (LA) functional indices using cardiac magnetic resonance (CMR) tissue tracking and volume-time curve in obese adults with no clinical signs or comorbidities. The association of LV diastolic function with fat distributions was also assessed. The results showed that CMR detected subclinical LV diastolic dysfunction, impaired LA reservoir and conduit function with preserved LV ejection fractions in adults with obesity. LV diastolic function was associated with LA reservoir and conduit function. Visceral fat was deleterious for LV diastolic function, while peripheral obesity might have had a protective effect. |
| 4165 | Booth 10
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Predictive value of cardiac magnetic resonance for reverse left ventricular remodeling after acute ST-segment elevation myocardial infarction |
| Jianing Cui1, Tao Li1, Yanan Zhao1, and Xiuzheng Yue2 | ||
1Department of Radiology, the First Medical center, Chinese People's Liberation Army Hospital, Beijing, China., Beijing, China, 2Philips Healthcare, Beijing, China, Beijing, China |
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Many ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI) are still exposed to a consequence known as left ventricular (LV) remodeling. Most studies have reported that reverse LV remodeling is associated with improved patient outcomes. Cardiac magnetic resonance (CMR) imaging has become a beneficial imaging modality to assess myocardial morphology, LV function and infarct characteristics simultaneously. This study assesses the predictive role of LV volume, LV function and infarct characteristics by CMR on reverse LV remodeling after STEMI. Our data showed that peak CK-MB, extent of MVO volume of LV were independent predictors of reverse LV remodeling. |
| 4166 | Booth 11
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Detail-preserving multi-scale deep learning reconstruction for cardiac magnetic resonance imaging |
| Juan Zou1, Cheng Li1, Ruoyou Wu1, Zhenzhen Xue1, Xin Liu1, Hairong Zheng1, and Shanshan Wang1 | ||
1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, shenzhen city, China |
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Fast data acquisition and high-quality image reconstruction are vital for dynamic MRI, which can capture both anatomical and temporal information. High-resolution acquisition approaches in k-space and super-resolution approaches after reconstruction have been frequently reported. However, these methods may get details lost at high acceleration factors. To address this issue, we propose a multi-scale detail preserving reconstruction method for dynamic MR images. The residuals of multi-scale intermediate images in the iterative procedure are explored and the temporal and spatial dependencies between frames are considered. Promising results are achieved by the proposed method at the high acceleration factor of 11. |
| 4167 | Booth 12
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Early MR radiomic biomarkers for re-hemorrhage after Gamma Knife Radiosurgery in Cavernous Malformation |
| Pei-Hsuan Kuo1, Cheng-Chia Lee2,3,4, Huai-Che Yang2,3, Hsiu-Mei Wu3,5, and Chia-Feng Lu1 | ||
1Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan, 2Department of Neurosurgery, Neurological Institute, Taipei Veteran General Hospital, Taipei, Taiwan, 3School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, 4Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, 5Department of Radiology, Taipei Veteran General Hospital, Taipei, Taiwan |
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Cavernous malformation (CM) is one of the common cerebral vascular diseases. Hemorrhage is a common and dangerous symptom of CMs, and re-hemorrhage may still occur in 30% of patients after the treatment of Gamma Knife radiosurgery (GKRS). Till now, the prediction of occurrences of future re-hemorrhage in CMs are still less explored. In this study, we used statistical analyses to observe longitudinal changes in MRI radiomic features before re-hemorrhage after GKRS. We aimed to identify the reliable image biomarkers using the quantitative and non-invasive MRI technique as early predictors to guide the clinical management for CM patients. |
| 4168 | Booth 1
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Comparative study between the Slow Infusion MR angiography and CT angiography in detection of the Adamkiewicz artery |
| Shohei Mizushima1, Takahiko Mine1, Masashi Abe1, Hiromitsu Hayashi2, Masahiro Fujii3, Tetsuro Sekine4, Taro Yokoyama1, Shinpei Ikeda1, Seigoh Happoh1, and Shin-ichiro Kumita2 | ||
1Radiology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Chiba, Japan, 2Radiology, Nippon Medical School Hospital, Tokyo, Japan, 3Cardiovascular surgery, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Chiba, Japan, 4Radiology, Nippon Medical School Musashikosugi Hospital, Kawasaki, Kanagawa, Japan |
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The Slow-Infusion MRA with SPGR provided the higher detectability of the AKA with whole patients, all AD patients, and with the AD patients whose AKA originating from false lumen in comparison with CTA. |
| 4169 | Booth 2
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Small-patch CNN and random forest to model and quantify the lenticulostriate artery from 7T time-of-flight MR angiography |
| Zhixin Li1,2,3, Dongbiao Sun1,2,3, Yue Wu1,2,3, Chen Ling4,5, Jing An6, Yun Yuan4,5, Zhaoxia Wang4,5, Rong Xue1,2,3, Yan Zhuo1,2,3, and Zihao Zhang1,2,3 | ||
1State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, Beijing, China, 2University of Chinese Academy of Sciences, Beijing, China, Beijing, China, 3The Innovation Center of Excellence on Brain Science, Chinese Academy of Sciences, Beijing, China, Beijing, China, 4Department of Neurology, Peking University First Hospital, Beijing, 100034, China, Beijing, China, 5Beijing Key Laboratory of Neurovascular Disease Discovery, Peking University First Hospital, Beijing, 100034, China, Beijing, China, 6Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, Shenzhen, China |
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Time-of-flight MR angiography at 7T allowed noninvasive visualization of the lenticulostriate artery (LSA). However, vasculature modeling of LSA remained challenging due to limited signal-to-noise ratio and pulsation artifact. In this study, we introduced an automated vascular segmentation and tracing method based on small-patch convolutional neural network (CNN), random forest, and multiple filtering. This method outperformed existing U-NET based methods and found radius changes of LSA branches in patients with cerebral small vessel diseases (cSVD). The automated quantification of LSA vasculatures will potentially facilitate diagnosis and clinical studies of cSVD. |
| 4170 | Booth 3
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Fast 3D Wheel Acquisition: Comparison of Efficacy for Cerebral MR Angiography with Conventional Parallel Imaging |
| Satomu Hanamatsu1, Kazuhiro Murayama2, Yoshiharu Ohno3, Kaori Yamamoto4, Yuki Obama1, Hirotaka Ikeda1, Hiroyuki Nagata1, Masato Ikedo4, Masao Yui4, Akiyoshi Iwase5, and Hiroshi Toyama1 | ||
1Radiology, Fujita Health University, School of Medicine, Toyoake, Japan, 2Joint Research Laboratory of Advanced Medical Imaging, Fujita Health University, School of Medicine, Toyoake, Japan, 3Radiology, Joint Research Laboratory of Advanced Medical Imaging, Fujita Health University, School of Medicine, Toyoake, Japan, 4Canon Medical Systems Corporation, Otawara, Japan, 5Radiology, Fujita Health University, Hospital, Toyoake, Japan |
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To the best of our knowledges, there are no major papers that assess the influence of Fast 3D wheel to cerebral MR angiography in patients with cerebrovascular diseases. We hypothesize that “Fast 3D wheel (Fast 3Dw)” has a potential to reduce examination time without degradation of image quality and aneurysm or vascular evaluations, when compared with PI. The purpose of this study was to directly compare the efficacy of Fast 3Dw for cerebral MR angiography with conventional PI in patients with cerebral aneurysm. |
| 4171 | Booth 4
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Comparison analysis of imaging techniques about routine, different acceleration factor coefficients of compressed sensing and PETRA TOF-MRA |
| Xiangcheng Hao1, Shaoyu Wang2, Huapeng Zhang2, He Zhao1, and Yang Gao1 | ||
1Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China, 2MR Scientific Marketing, Siemens Healthineers, Shanghai, China |
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We compare three MRA techniques between CS-TOF, PI-TOF and PETRA-TOF about imaging quality and speed, and also compared the effects of different acceleration factor coefficients (4.6×, 7.2×, 10.3×) on CS-TOF-MRA images on a 3T MR scanner. |
| 4172 | Booth 5
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Non-contrast-enhanced mDixon water-fat separation whole-heart coronary MRA with a deep learning constrained Compressed SENSE reconstruction |
| Wenyun Liu1, Lei Zhang1, Cheng Li2, Yuejiao Sun1, Ying Qiu1, Yi Zhu3, Ke Jiang3, Shuo Wang1, and Huimao Zhang1 | ||
1Department of Radiology, The First Hospital of Jilin University, Changchun, China, 2Department of Cardiovascular center, The First Hospital of Jilin University, Changchun, China, 3Philips Healthcare, Beijing, China |
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The conventional 3D whole-heart free-breathing coronary MR angiography suffers from a long scan time. However, using very high acceleration factors leads to degradation of image quality due to insufficient noise removal. In this study, we use Compressed-SENSE Artificial Intelligence (CS-AI) framework to acquire highly accelerated 3D non-contrast-enhanced mDixon water-fat separation whole-heart CMRA. The result shows that CS-AI reconstruction can significantly decrease scan time with sufficient image quality compared to Compressed-SENSE(CS) and might be clinically useful in assessment of coronary artery disease. |
| 4173 | Booth 6
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Non-contrast enhanced spatially-selective and time-resolved vessel imaging by using cylinder-shaped pre-saturation pulse train in the Lung |
| Masahiro Takizawa1, Takashi Nishihara1, and Chikako Moriwake1 | ||
1Radiation Diagnostic System Division, FUJIFILM Healthcare Corporation, Kashiwa-shi, Japan |
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Cylinder-shaped pre-saturation pulse train is developed for non-contrast enhanced spatially-selective and time-resolved vessel imaging. The target vessel is selected by cylinder-shaped pre-saturation, and the dynamics of blood flow in the target vessel is observed by changing the number of applied pre-saturation pulses. The developed pulse train was demonstrated to visualize dynamics of a target pulmonary vessel in the lung. |
| 4174 | Booth 7
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Characterization of Corticospinal Tract Injury along Fibers by Automated Fiber Quantification in Stroke |
| Fan Liu1, Yu Wei1, Qiurong Yu1, Hewei Wang2, Dazhi Yin3, Guojun Xu1, Miao Guo1, Ling Liu1, Qianwen Li1, and Mingxia Fan1 | ||
1Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, China, 2Department of rehabilitation, Huashan Hospital, Fudan University, Shanghai, China, 3School of Psychology and Cognitive Science, East China Normal University, Shanghai, China |
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Previous DTI studies mainly detected partial ROIs or mean diffusion profiles of corticospinal tract (CST), few revealed changes along CST trajectory. We used Automated Fiber Quantification (AFQ) derived from DTI to investigate whether diffusion parameters changes were localized to its specific regions or spread throughout. The results showed AFQ traced out a clearer picture of the damaged CST along its trajectory in patients with hemiplegia after stroke. Furthermore, the severity of several damaged CST segments was correlated with motor scores, possibly providing more accurate and reliable "target" regions for assessing clinical prognosis and the efficacy of motor rehabilitation. |
| 4175 | Booth 8
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Atherosclerotic ischemic recurrent stroke patients: a nomogram model of risk factors and risk prediction |
| Niane Ma1, XiaoLing Zhang1, Xiaoyan Lei1, Min Tang1, Ling Li1, Xuejiao Yan1, and Kai Ai2 | ||
1Shaanxi Provincial People's Hospital, Xi’an, China, 2Philips healthcare, Xi’an, China |
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The aim of this study was to construct a diagnostic model of recurrent stroke with the combination of high resolution MRI imaging characteristics and clinical parameters. The vessel wall characteristics of plaque and clinical data were compared between stroke and recurrent stroke patients. Multivariate logistic regression analysis was explored, seven risk factors (plaque burden, fibrous cap, hyperdense, hemorrhage, HbA1, low density lipoprotein and smoke) were independent risk factors for recurrent stroke patients. Then a nomogram model was established for risk prediction. |
| 4176 | Booth 9
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Venous Response in Brains with Ischemic Stroke Assessed with Susceptibility-Based MR Imaging |
| Shihui Zhou1,2, Zhiqiang Wei3, Yulong Qi4, Li Yi3, Siqi Cai1,2, Chunxiang Jiang1,2, and Lijuan Zhang*1 | ||
1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2University of Chinese Academy of Sciences, Beijing, China, 3Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, China, 4Department of Radiology, Beijing University Shenzhen Hospital, Shenzhen, China |
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Venous response has been overlooked in the characterization of ischemic stroke (IS). In this study, vein density (VD) and oxygen extraction fraction (OEF) were assessed as indices of venous response for both the ipsi- and contra-lesional hemispheres in a cohort of patient with corona radiata IS using susceptibility MR imaging. Relative VD and OEF (ratios between the averaged ipsilesional and contralesional measurements) increased from early (1-7 days) to late subacute stages of IS (7-15 days). Patients with lesion in right corona radiata showed more extensive interhemispheric difference in OEF, suggesting an anatomy specific distribution of the venous response after IS. |
| 4177 | Booth 10
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Time estimation from stroke onset with diffusion-relaxation matrix-based T2 and ADC simultaneous mapping |
| Hajime Yokota1, Takayuki Sakai2, Masami Yoneyama3, and Takashi Uno1 | ||
1Department of Diagnostic Radiology and Radiation Oncology, Chiba University, Chiba, Japan, 2Department of Radiology, Eastern Chiba Medical Center, Togane, Japan, 3Philips Japan, Tokyo, Japan |
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Diffusion-relaxation matrix (DRM) sequence consists of dual-echo single-shot DW-EPI. DRM was able to detect acute cerebral infarction as well as conventional DWI, and can simultaneously acquire ADC and T2 values. T2 values in the infarcted area correlated significantly with time since stroke onset, whereas ADC did not. In addition, T2 values could predict whether the infarct was within 4.5, 6, or 16 hours, which are the thresholds for thrombolysis and endovascular treatment. |
| 4178 | Booth 11
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Early Dynamics of Regional Volume and Diffusion Characteristics after Experimental Neonatal Hypoxic Ischemia with Different Damage Outcomes |
| Po-Yu Chan1, Chiao-Ching Huang2, Chia-Feng Lu1, Bao-Yu Hsieh3, and Yu-Chieh Jill Kao1 | ||
1Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan, 2Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 3Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang-Gung University, Taoyuan, Taiwan |
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To stratify neonates with different outcomes of hypoxic ischemia (HI) within few hours after birth for the subsequent therapeutic hypothermia, the spatiotemporal profile of MR measurements between two severity outcome groups was depicted as early at 6 h after insult. Changes in volumes, ADC and FA values were observed among different brain regions, suggesting different susceptibility of brain regions to HI in the acute phase of HI. |
| 4179 | Booth 12
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Deep learning for term neonate hypoxic ischemic encephalopathy diagnosis on structural brain MR images: a retrospective study |
| Tongjia Gan1, Wenzhen Zhu1, Jingjing Shi1, and Wenzhi Lv2 | ||
1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2Department of Artificial Intelligence, Julei Technology Company, Wuhan, China |
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This study aims to diagnose objectively term neonate hypoxic ischemic encephalopathy (HIE) by using deep learning network to extract deep information from multiple modalities of conventional magnetic resonance (MR) images. Neonate HIE diagnosis accuracy is restricted to lesion diversity, MR images quality, high interobserver variability. The network got high diagnosis accuracy in the ROC curve. The network could detect severe neonate HIE with characteristic appearance such as basal ganglia injury and periventricular leukomalacia. The network can help diagnosis neonate HIE objectively without the effect of different radiologist experience and contribute to risk stratification and clinical decision making. |
| 4180 | Booth 13
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Fiber-specific white matter reductions in older adults with metabolic syndrome |
| Christina Andica1, Koji Kamagata1, Wataru Uchida1, Kaito Takabayashi1, Yuya Saito1, Keigo Shimoji1,2, Hideyoshi Kaga3,4, Yuki Someya3, Yoshifumi Tamura3,4, Ryuzo Kawamori3,4, Hirotaka Watada3,4, Masaaki Hori1,5, and Shigeki Aoki1 | ||
1Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan, 3Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 4Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 5Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan |
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We performed fixel-based analysis, which implements the Multi-Shell Multi-Tissue Constrained Spherical Deconvolution method, to investigate the effect of metabolic syndrome (MetS) on fiber-specific white matter (WM) integrity and assess its association with MetS-related components or cognitive or motor functions. Our findings provide evidence of WM degeneration, as reflected by reduced microstructural fiber density and macrostructural fiber bundle cross-section, in regions associated with cognitive and motor functions in MetS. We also observed reduced fiber density in the corticospinal tract in preMetS. Finally, our findings clarified visceral fat accumulation, insulin resistance, and arterial stiffness as risk factors for WM alterations in MetS. |
| 4181 | Booth 14
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Evaluation of Secondary Prevention Effectiveness of Ginkgo Biloba Extract (EGb 761) in Acute Ischemic Stroke by QSM and Venous Oxygen Saturation |
| Wen-Ting Lan1, Yue-Fei Wu2, Hui Zhang1, Xin-Zhong Ruan1, Yi Huang3, Xiao-Jing Li4, and Yunzhu Wu5 | ||
1Department of Radiology, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo, China, 2Department of Neurology, Ningbo First Hospital, Ningbo, China, 3Department of Neurosurgery, Ningbo First Hospital, Ningbo, China, 4Department of Gerontology, Ningbo First Hospital, Ningbo, China, 5MR Scientific Marketing, SIEMENS Healthineers, Shanghai, China |
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In this study, we applied quantitative susceptibility mapping (QSM) and venous oxygen saturation measurement in acute ischemic stroke patients who took ginkgo biloba extract (EGb 761) treatment. EGb 761’s secondary prevention effectiveness of ischemic stroke patients with cerebral microbleeds was similar to Aspirin. Furthermore, Ginkgo biloba extract could not only improve neuroprotective efficiency and prognosis by increasing oxygen saturation of the vein near infarction, but also could reduce the incidence of adverse side effects such as gastrointestinal ulcers and bleeding usually caused by Aspirin. |
| 4182 | Booth 15
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Aberrant Spontaneous Brain Activity in Coronary Heart Disease: A Preliminary Resting-State Functional MRI Study. |
| Simin Lin1, PuYeh Wu2, and Hengyu Zhao1 | ||
1Xiamen Cardiovascular Hospital of Xiamen University, Xiamen, China, 2GE Healthcare, Beijing, China |
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Coronary heart disease is an urgent, rapidly-developing disease with high disability and mortality. Previous studies indicated that CHD patients exhibited an increased risk of mild cognitive and emotional dysfunction. Here we collected rs-fMRI data to assess global brain activity in CHD patients and controls by measuring fALFF. We demonstrated that CHD patients occur abnormal brain activity in left precentral/postcentral gyrus and right inferior cerebellum, which is mainly related to sensorimotor network and pain processing. Spontaneous brain activity abnormalities may contribute to understanding underlying neurological mechanisms of CHD. |
| 4436
|
Booth 1
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Stochastic Fibrosis Signatures from 3D LGE: Novel Threshold-Free Quantification of Left Atrial Fibrosis |
| Mehri Mehrnia1,2, Eugene Kholmovski3, Rod Passman4, Aggelos Katsaggelos1,5,6, Saman Nazarian7, Daniel Kim1, and Mohammed Elbaz1 | ||
1Radiology, Northwestern University, Chicago, IL, United States, 2Biomedical Engineering, Northwestern University, Chicago, IL, United States, 3Johns Hopkins University, Baltimore, MD, United States, 4Cardiology, Northwestern University, Chicago, IL, United States, 5Electrical and Computer Engineering, Northwestern University, Chicago, IL, United States, 6Computer Science, Northwestern Universiy, Chicago, IL, United States, 7Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States |
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Assessment of left atrial (LA) fibrosis in atrial fibrillation (AF) patients from 3D LGE MRI have shown promise in evaluating atrial myopathy for selecting patients for catheter ablation and to predict AF recurrence post intervention. Nevertheless, current methods for fibrosis quantification suffer from lack of standardization and reproducibility as they rely on different thresholds for defining fibrosis. Hence, limiting the clinical translation of 3D LA LGE MRI. Here, we propose the first threshold-free technique to quantify LA fibrosis burden using novel stochastic fibrosis signature technique. We demonstrated feasibility and correlations to four of the previously published methods for fibrosis quantification. |
| 4437 | Booth 2
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CMR of fetal cardiac function and blood flow with doppler ultrasound cardiac gating |
| Erin K Englund1, Lorna P Browne1, Takashi Fujiwara1, Richard Friesen2, Mehdi H Moghari1, and Alex J Barker1 | ||
1Radiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, United States, 2Pediatric Cardiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, United States |
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Fetal CMR is difficult due to the lack of an ECG signal, fetal motion, small anatomic sizes and high fetal heart rates. Initial results are presented which use a doppler ultrasound gating device to capture fetal cardiac motion in standard cardiac views and blood flow was quantified with 4D flow MRI. bSSFP cine images were scored for image quality by two radiologists and flow in the umbilical vein, ascending aorta and main pulmonary artery were quantified and agreed well with reported values. Unique insight was provided with dynamic imaging regarding the fetal circulation and the impact of congenital disease. |
| 4438 | Booth 3
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Free-breathing Fully Ungated 3D Cardiac T2* MR Mapping using a Low-Rank Tensor Framework |
| Xingmin Guan1,2, Hsin-Jung Yang1, Zhehao Hu2,3, Nan Wang4, Anthony Christodoulou1, Behzad Sharif5, Debiao Li1, and Rohan Dharmakumar2,5 | ||
1Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2University of California, Los Angeles, Los Angeles, CA, United States, 3University of Southern California, Los Angeles, CA, United States, 4Stanford University, Stanford, CA, United States, 5Indiana University, Indianapolis, IN, United States |
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A 3D fully ungated, free breathing cardiac T2* technique was developed using a low-rank tensor framework. An animal model with iron-oxide contrast-enhanced studies was used to test and validate the proposed technique. T2* images reconstructed from the proposed approach showed better image quality than those from conventional 2D T2* imaging approach. Excellent agreement of septal T2* was found between the proposed approach and conventional 2D approach. Our findings show that the proposed approach can accurately characterize T2* of myocardium under baseline and during iron overload conditions. |
| 4439 | Booth 4
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Accelerated cardiac T1 mapping with bidirectional LSTMs and cyclic model-based loss |
| Johnathan V. Le1,2, Jason K. Mendes2, Mark Ibrahim3, Brent D. Wilson3, Edward V.R. DiBella1,2, and Ganesh Adluru1,2 | ||
1Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, United States, 2Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, United States, 3Department of Cardiology, University of Utah, Salt Lake City, UT, United States |
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Cardiac T1 mapping has been shown to be a promising method for assessing different cardiomyopathies. Most cardiac T1 mapping methods require long breath holds during the acquisition which can be difficult for patients particularly during exercise or pharmacologically induced stress. Here we proposed using a multi-layer bidirectional LSTM with fully connected output and a cyclic model-based loss function to reduce the acquisition time of T1 mapping sequences without significant loss of quality. |
| 4440 | Booth 5
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Free-running Simultaneous 3D Cardiac T1 Mapping and Cine Imaging Using a Linear Tangent Space Alignment Model |
| Yanis Djebra1,2, Thibault Marin1, Paul Kyu Han1, Isabelle Bloch3, Georges El Fakhri1, and Chao Ma1 | ||
1Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 2LTCI, Telecom Paris, Institut Polytechnique de Paris, Paris, France, 3LIP6, Sorbonne University, CNRS, Paris, France |
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Cardiac T1 mapping allows assessment of tissue characteristics and functioning of the heart. However, existing methods are limited in terms of spatial resolution and coverage due to limitations in acquisition speed and the presence of cardiac and respiratory motion. This work proposes a new reconstruction framework for simultaneous, high-resolution 3D cardiac T1 mapping and cine imaging of the heart at 3T from sparsely sampled k-space data. |
| 4441 | Booth 6
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Restored Torsion and Longitudinal Strain in ACE Inhibitor Treated Hypertension |
| Alexander Wilson1,2, Gregory B Sands3, Vicky Y Wang2, Beau Pontre4, Daniel B Ennis1,2, Alistair A Young5, Ian J LeGrice3, and Martyn P Nash3,6 | ||
1Stanford Cardiovascular Institute, Stanford University, Stanford, CA, United States, 2Department of Radiology, Stanford University, Stanford, CA, United States, 3Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand, 4Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand, 5Department of Biomedical Engineering, King's College London, London, United Kingdom, 6Department of Engineering Science, University of Auckland, Auckland, New Zealand |
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Tagged CMR was used to measure torsion and longitudinal strain in a rodent model of hypertensive heart disease. Long-term ACE inhibitor treatment restored ejection fraction, torsion and longitudinal strain by 24 months of age. Longitudinal strain was the first functional measure to be restored, and this may indicate that longitudinal strain is a sensitive imaging biomarker for assessing the efficacy of treatment with regards to reverse remodeling in hypertension. |
| 4442 | Booth 7
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Early Detection of Radiation-Induced Cardiotoxicity Using Hyperpolarized Pyruvate |
| Junjie Ma1, Jun Chen1, Elizabeth Zhang-Velten2, Jayesh Sharma2, Xuliang Wang3, Gabriele Schiattarella3, Thomas Gillette3, Joseph Hill3,4, Craig R. Malloy1,3,5, Vlad G. Zaha1,3, Jae Mo Park1,5,6, and Prasanna Alluri2 | ||
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, United States, 3Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, 4Molecular Biology, UT Southwestern Medical Center, Dallas, TX, United States, 5Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 6Electrical and Computer Engineering, UT Dallas, Richardson, TX, United States |
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Radiation-induced heart disease is a major source of morbidity and mortality in patients receiving thoracic radiation. In this study, radiation-induced changes in cardiac metabolism is investigated using hyperpolarized [1-13C]pyruvate MRI in animals and patients. Myocardial bicarbonate-to-lactate ratios decreased following radiation treatments while no change was observed in the global strain, suggesting radiation-induced mitochondrial dysfunction in the heart. This translational study demonstrates clinical potential of hyperpolarized 13C pyruvate for early and noninvasive detection of radiation-induced cardiac injury. |
| 4443 | Booth 8
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Influence of Spatial Resolution in T2* Maps of Intramyocardial Hemorrhage |
| Xinheng Zhang1,2, Hsin-Jung Yang1, and Rohan Dharmakumar3 | ||
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Bioengineering Department, UCLA, Los Angeles, CA, United States, 3Krannert Cardiovascular Research Center, Indiana University School of Medicine, Indianapolis, IN, United States |
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The influence of spatial resolution on T2*-based characterization of hemorrhage within myocardial infarctions (MI) has not been investigated. We hypothesized that partial volume could play a critical role in the detection and quantification of hemorrhagic remnants. Ex-vivo pig hearts with 8-week old MI were imaged with multi-gradient echo sequences with various in-plane and through-plane spatial resolutions. Our findings show that optimal detection of hemorrhagic remnants with T2* MRI at 3T requires imaging voxels to be between 5 and 7 mm3. |
| 4444 | Booth 9
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Simultaneous T1, T2, and T1ρ Mapping of the Myocardium with Multi-Parametric SASHA |
| Kelvin Chow1, Hui Xue2, and Peter Kellman2 | ||
1Cardiovascular MR R&D, Siemens Healthineers, Chicago, IL, United States, 2National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States |
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Parametric T1 and T2 mapping can provide valuable insight into myocardial tissue microstructure. T1ρ is a complimentary technique that is sensitive to macromolecular content and may potentially enable non-contrast scar visualization. Characterization with all parameters is desirable as they may have different sensitivities to pathology but is time consuming with separate acquisitions for each. We propose a novel mSASHA sequence with T1, T2, and T1ρ maps in a single 13 HB breath-hold or free-breathing acquisition. mSASHA had superior T1 and T2 accuracy and similar precision to conventional MOLLI and T2p-bSSFP in phantoms and data is presented from 3 volunteers. |
| 4445 | Booth 10
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Accelerated MRI of epicardial adipose tissue fatty acid composition in mice using a compressed-sensing and dictionary-based reconstruction |
| Soham Shah1 and Fred H Epstein1 | ||
1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States |
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Epicardial adipose tissue (EAT) and its fatty acid composition (FAC) have been implicated in numerous cardiovascular diseases as saturated fatty acids are known to promote inflammation. FAC MRI techniques, while prominent, have not been applied to EAT due to extended scan times, thus, image acceleration is essential. Here, we demonstrate compressed sensing with a signal model-based dictionary (CS-DICT) to reconstruct psuedo-random undersampled images. Using CS-DICT, we achieve rate-3 acceleration while maintaining accurate EAT FAC maps and estimations in obese mice. These methods facilitate the application of FAC MRI to the EAT. |
| 4446 | Booth 11
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Cardiac and Respiratory-Resolved Image Reconstruction with the Beat Pilot Tone |
| Kathryn Lamar-Bruno1, Suma Anand1, and Michael Lustig1 | ||
1Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, United States |
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We have previously proposed Beat Pilot Tone (BPT), a motion sensing method using ultra-high-frequency RF and preamplifier intermodulation. BPT uses ultra-high-frequencies, which provides greater sensitivity to motion compared to the Pilot Tone (PT). In this work, we use the motion estimates from the BPT to reconstruct respiratory and cardiac-resolved images and compare them to motion-resolved images obtained using PT, respiratory bellows, and electrocardiogram (ECG) data. We show that BPT provides comparable image quality to conventional motion sensing for respiratory and cardiac motion. |
| 4447 | Booth 12
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Simultaneous estimation of longitudinal relaxation time and intracellular water lifetime using Active Contrast Encoding MRI |
| Jin Zhang1, Karl Kiser1, Ayesha Bharadwaj Das1, Sawwal Qayyum1, and Gene Kim1 | ||
1Weill Cornell Medical College, New York, NY, United States |
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Dynamic contrast enhanced (DCE)-MRI can be used as a tool to measure intracellular water lifetime (τi) in tumor cells which can be used as a biomarker for tumor aggressiveness and treatment response. Contrast kinetic model analysis in DCE-MRI requires accurate pre-contrast T1 measurement. We used multiple flip angles for active contrast encoding of both T1 and τi during dynamic data acquisition with one injection. The present study demonstrates the feasibility of measuring T1 and τi simultaneously from the active contrast encoding (ACE) MRI data. ACE-MRI also reduces the scan time by eliminating the need of separate pre-contrast T1 measurement. |
| 4448 | Booth 13
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High-Performance 0.55T Supports Contrast-Optimal SMS bSSFP Cardiac Imaging |
| Ye Tian1, Sophia X. Cui2, Yongwan Lim1, Nam G. Lee3, Ziwei Zhao1, and Krishna S. Nayak1 | ||
1Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, 2Siemens Medical Solutions USA, Inc., Los Angeles, CA, United States, 3Biomedical Engineering, University of Southern California, Los Angeles, CA, United States |
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Balanced steady-state free precession (bSSFP) cardiac cine MRI at 1.5T and 3T is routinely used for cardiac function assessment. Simultaneous multi-slice (SMS) imaging significantly reduces the number of required breath holds, but is typically performed with suboptimal flip angles (FA) due to SAR constraints and banding artifacts, both of which are significantly relaxed at 0.55T. In this work, we demonstrate blipped-CAIPI bSSFP cine imaging combined with spiral sampling for ventricular function at 0.55T with optimal FA for blood-myocardium contrast (100o-120o) at SMS factors of 2 and 3. |
| 4449 | Booth 14
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Quantitative Susceptibility Mapping for Chamber Blood Oxygenation in Pulmonary Hypertension: Validation using Right Heart Catheterization |
| Jiahao Li1,2, Katherine Tak3, Rachel Meier3, Pablo Villar-Calle3, Justin Johannesen3, Jiwon Kim3, Yi Wang1,2, Jonathan W. Weinsaft3, and Pascal Spincemaille2 | ||
1Biomedical Engineering, Cornell University, New York, NY, United States, 2Radiology, Weill Cornell Medicine, New York, NY, United States, 3Medicine, Weill Cornell Medicine, New York, NY, United States |
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Pulmonary hypertension (PH) is a progressive and life shortening disorder with increased differential blood oxygen saturation (ΔSaO2) between right and left heart. In this prospective study, we acquired cardiac QSM from patients undergoing clinically indicated right heart catheterization (RHC) for assessment of known or suspected PH. ΔSaO2 estimated from QSM aligned well with RHC oxygenation data, showing QSM as a non-invasive CMR technique can be applied to clinically evaluate heart chamber oxygenation quantification in PH. |
| 4450 | Booth 15
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Population analysis of B0 magnetic field conditions in the human heart |
| Yun Shang1, Sebastian Theilenberg1, Boyu Peng2, Sachin R. Jambawalikar1,2, Laura M. Schreiber3,4, and Christoph Juchem1,2 | ||
1Department of Biomedical Engineering, Columbia University, New York, NY, United States, 2Department of Radiology, Columbia University Irving Medical Center, New York, NY, United States, 3Section of Medical Physics, Department of Radiology, Mainz University Hospital, Mainz, Germany, 4Chair of Molecular and Cellular Imaging, Comprehensive Heart Failure Center (CHFC), Würzburg, Germany |
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Cardiac MRI suffers susceptibility-induced artifacts due to B0 inhomogeneity across the heart. The lack of population data in cardiac B0 conditions and the practical inability to obtain such data in large populations impedes the development of optimal cardiac B0 shim strategy. Here, we establish population-based B0 conditions from readily available CT images and simulate cardiac B0 maps of 254 CT subjects with broad demographic parameters. The results are expected to develop optimal subject- and population-specific cardiac B0 shim strategies. |
| 4462 | Booth 1
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Clinical features and CMR derived Left ventricular dysfunction in Obese Heart Failure with Preserved Ejection Fraction |
| jian he1, Jing Xu1, and Minjie Lu1 | ||
1fuwai hospital, Beijing, China |
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In this well-defined cohort of prospectively studied 101 obese Heart failure with preserved ejection fraction (HFpEF), 46 normal-weight HFpEF patients and 30 clinically healthy controls, we illustrated clinical features of obese HFpEF phenotype with more remarkable inflammation response, and cardiovascular magnetic resonance (CMR) derived left ventricular remodeling and worse subtle dysfunction, compared to normal-weight HFpEF and clinically healthy controls. In addition, diastolic dysfunction (impaired EGLSR, EGCSR, and EGRSR) and subtle systolic dysfunction were more prominent characteristics of obese HFpEF patients, showed modest to moderate correlations with body mass and estimated plasma volume, and assisted in the diagnosis of obese HFpEF. |
| 4463 | Booth 2
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Association and Prediction of Intracranial Plaque Characteristics and Hs-CRP Levels In Patients with Acute Cerebral Infarction |
| Rui-Ying Li1, Deng-Ling Zhao1, and Xian-Ce Zhao2 | ||
1Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China, 2Philips Healthcare, Shanghai, China |
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Atherosclerosis accompanied by inflammation is considered to be a crucial mechanism for patients with ischemic stroke. We aimed to investigate the association between intracranial plaque characteristics and high-sensitivity C-reactive protein (hs-CRP) levels to predict the occurrence of acute cerebral infarction (ACI). 85 patients with cerebral infarction were divided into ACI group and non-acute cerebral infarction (NACI) group. Hs-CRP levels were further grouped into low, intermediate and high groups. We concluded that elevated hs-CRP levels was independently associated with strong plaque enhancement, their synergistic effects provided incremental value in predicting the occurrence of acute cerebral infarction. |
| 4464 | Booth 3
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Multi-parametric imaging on cerebral infarction using MULTIPLEX |
| Jiali Zhong1, Yongquan Ye2, Hongyu Yang1, Zhongqi Zhang2, Jingyuan Lyu2, Weijun Zhang3, Jian Xu2, and Ruchen Peng1 | ||
1Radiology, Beijing Luhe Hospital, Capital Medical University, Beijing, China, 2UIH America, Inc., Houston, TX, United States, 3United Imaging Healthcare Co., Ltd., Shanghai, China |
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A state-of-the-art multi-parametric imaging method, namely MULTIPLEX, was evaluated for its potential for cerebral infarction. The MULTIPLEX method offered single-scan multi-contrast information with 3D high resolution images, not only showing the capacity to supplement or replace routine protocols for anatomical and edema imaging, but also offered additional information on bleedings and penumbra, showing the potential as an one-click solution for daily cerebral infarction imaging. |
| 4465 | Booth 4
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A study on structural changes of limbic systems in cerebral small vascular disease patients with mild to moderate depression |
| Kun Li1, Dongtao Liu2, Xiuqin Jia1, Qiao Bu1, Rui Jia1, Tao Jiang1, Yueluan Jiang3, Qinglei Shi3, Zhenyu Pan1, and Lichun Zhou2 | ||
1Department of Radiology, Beijing Chao Yang Hospital, Beijing, China, 2Department of Neurology, Beijing Chao Yang Hospital, Beijing, China, 3MR Scientific Marketing, Siemens Healthineers, Beijing, China |
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Major depressive disorder severity is associated with limbic systems grey matter volumetric reductions, while for cerebral small vascular disease (CSVD) patients with mild to moderate depression the pathological mechanism needs to be future investigated. Diffusion kurtosis imaging (DKI) is an advanced diffusion model that characterizes water diffusion process as non-Gaussian distribution. DKI parameters are highly sensitive to the micro-environment of tissues, especially for the anisotropic structure. This study aimed to investigate the structure changes of limbic systems in patients with cerebral small vascular disease (CSVD) induced mild to moderate depression by applying diffusion kurtosis imaging. |
| 4466 | Booth 5
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Quantitative assessment of intracranial venous sinus thrombosis using MR 3D T1 SPACE imaging |
| Jingtong Xiong1, Xiaofeng Qu1, Jie Bian1, Jianlin Wu2, and Chen Zhang3 | ||
1Radiology, The Second Hospital of Dalian Medical University, Dalian, China, 2Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China, 3MR Scientific Marketing, Siemens Healthineers, Beijing, China |
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This study explores the feasibility of MR 3D T1 SPACE sequence in diagnose and differential diagnosis of Cerebral sinus venous thrombosis (CSVT) . The clinical phase of CVST in accordance with onset of symptom often lags behind image characters. Results showed that no obvious scientific difference was found among clinical phase groups. However, the differences between the acute, subacute and chronic imaging groups were statistically significant. Besides, CE rate of CVST in superficial veins was found higher than that in deep veins. MR 3D T1 SPACE has the potential to improve the accuracy of early diagnosis of CVST. |
| 4467 | Booth 6
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Detect the etiology of single small subcortical infarction with High Resolution-Vessel Wall Imaging |
| Tong Han1, Yutian Li1, Hui Wang1, Jinli Li1, and Xianchang Zhang2 | ||
1Department of Radiology, Tianjin Huanhu Hospital, Tianjin University, Tianjin, China, 2MR Collaboration, Siemens Healthineers Ltd., Beijing, China |
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This study used high resolution vessel wall imaging to investigate the lenticulostriate artery (LSA) morphology and plaque characteristics in three patient groups: single small subcortical infarction (SSI) with/without plaque on the parental artery, and large subcortical infarction with large artery atherosclerosis (LAA) as reference. SSI with plaque (SUD) on the parental artery manifested more like LAA, having relatively lower total CSVD score and lower number and total length of LSA branches. However, the plaques in SUD were mainly positive remodeling. These findings reinforce our understanding about the etiology of SSI with plaque on the parental artery. |
| 4468 | Booth 7
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Pericarotid fat density was associated with carotid plaque vulnerability, especially IPH and TRFC |
| Miao Yu1, Yankai Meng1, Beiru Wang1, Yaqiong Ge2, and Kai Xu1 | ||
1the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China, 2GE Healthcare，Precision health institution，China., Shanghai, China |
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Inflammation play important roles in the vulnerability of atherosclerotic plaque. Pericoronary fat is associated with coronary heart disease and high-risk plaque, however the value of pericarotid fat density (PFD) remains uncertain. We evaluated the association between PFD on computed tomography angiography (CTA), with the vulnerable composition of carotid plaques. We found that the PFD was independently associated with vulnerability of carotid plaque especially for IPH and TRFC, suggesting that pericarotid fat tissue may play a key role in the occurrence of vulnerable plaques. The identification of local perivascular inflammation may help identify patients who may benefit from targeted therapy. |
| 4469 | Booth 8
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Tetrahedral based Method for Intracranial Blood Vessels Volume Calculation |
| Runyu Yang1, yuze li1, and Huijun Chen1 | ||
1Center for Biomedical Imaging Research, Tsinghua University, Beijing, China |
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The rupture of intracranial atherosclerotic plaque is a major cause of ischemic stroke. The atherosclerotic plaque burden was proposed to measure the risk of plaque vulnerability, which can be quantified by the volume of the vessel wall calculated on MR images. However, due to the complex shape of intracranial blood vessels, the traditional calculation method may reduce the accuracy of plaque burden measurement,especially overlapped in the curved vessels. Therefore, a tetrahedral based method was proposed to reduce the volume calculation error of intracranial vessel wall. The proposed method was validated in simulation and in-vivo datasets. |
| 4470 | Booth 9
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Wall Enhancement of Unruptured Intracranial Aneurysm on MR Imaging is Associated with Irregular Pulsation Detected by Four-dimensional CTA |
| Jianjian Zhang1, Xiao Li1, Chengcheng Zhu2, and Huilin Zhao1 | ||
1Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, shanghai, China, 2University of Washington, Seattle, WA, United States |
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Both aneurysm wall enhancement (AWE) and irregular pulsation have been suggested as potential candidates for intracranial aneurysms (IAs) instability. No studies have explored the association between AWE and irregular pulsation. By using vessel wall MRI and four-dimensional computed tomography angiography, we found a significantly strong correlation between AWE and irregular pulsation (phi coefficient=0.569, p<0.001). IAs with irregular pulsation had much less AWE grade 0 and more AWE grade 1, 2 and 3 compared with IAs without irregular pulsation (all p<0.05). Further longitudinal studies are needed to validate the role of the two imaging markers in predicting aneurysm growth and rupture. |
| 4471 | Booth 10
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Study on Plasma BDNF Concentration and Rs-fMRI Characteristics Related to Motor Function |
| Yujie Lu1,2, Wenmei Li1, and Huiting Zhang3 | ||
1Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China, 2Radiology, ,Sichuan Cancer Hospital and Institute, Chengdu, China, 3Siemens Healthcare, Beijing, China |
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Results of our study showed that the level of plasma brain derived neurotrophic factor (BDNF) was positively correlated with cognitive function, and negatively correlated the changes in local brain network related to the destruction of motor and non-motor cortical areas in the hemispheres using rs-fMRI in capsular stroke (CS) group. Follow-up results demonstrated the mechanism of local dynamic network remodeling and its correlation with plasma BDNF concentration and clinical outcomes. It provides temporal and spatial information for the dynamic separation of brain networks in different stage of CS, and reflects the potential biological mechanism of proportional recovery. |
| 4472 | Booth 11
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The influence of scanning order on whole-heart coronary MRA with multiple compressed sensing acceleration factors |
| guangzong su1, yang wu1, xiaojing ma1, dongsi shuang1, ting peng1, haixia li2, and peng sun3 | ||
1Wuhan Asia general Hospital, WuHan HUBEI, China, 2Philips Healthcare,wuhan, WuHan HUBEI, China, 3Philips Healthcare,Beijing, Beijing, China |
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Compressed sensing (CS) is a novel magnetic resonance imaging technique to accelerate scanning under the premise of ensuring image quality. Whole-heart coronary MRA with CS technique can assess coronary artery lesions. However, the image quality is still sensitive to many factors. In this study, we demonstrated that there were statistical differences in parts of image quality with different scan orders when using CS AF of 6, where the scanning at the late stage of examinations showed high image quality. It might be the optimal choice to start coronary MRA scanning later in cardiac MRI practice. |
| 4473 | Booth 12
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Comparison of 5T and 3T MRI in patients with moyamoya disease: An initial study |
| Sirui Li1, Mengqi Tu1, Dan Xu1, Shihong Han2, Shuheng Zhang2, Wenbo Sun1, Jinchao Chen3, Haibo Xu1, and Jianjian Zhang3 | ||
1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China, 2United Imaging Healthcare, Shanghai, China, 3Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China |
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In this study, a 5.0T whole body MR imaging system was used for the evaluation of moyamoya disease (MMD). Diagnostic performance of time-of-flight magnetic resonance angiography (TOF-MRA) and susceptibility-weighted imaging (SWI) were evaluated and compared between the 5T MRI scanner and a clinical 3T MRI scanner in three MMD patients. Preliminary results show that 5 T MRI might be superior to 3T MRI for the visualization of small collateral branches and micro bleeding points. |
| 4474 | Booth 13
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Compressed sensing improved the assessment of the corticospinal pathways in stroke brains scanned with traditional DTI |
| Yuguang Meng1 and Xiaodong Zhang1,2 | ||
1Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, 2Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory Univeristy, Atlanta, GA, United States |
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Conventional diffusion tensor imaging (DTI) has been widely used to examine white matter connectivity with neurological diseases but is limited in detecting pathways with crossing fibers. As the crossing fibers are abundant in large and complicated brains like human and non-human primate brains, the DTI tractography results may be biased substantially. In stroke research, the integrity of corticospinal tract (CST) plays a critical role in assessing the motor function. In this study, a compressed sensing technique was explored to improve the CST delineation with conventional DTI, and the feasibility was evaluated by using a monkey model of stroke. |
| 4475 | Booth 14
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Non-contrast enhanced MR vessel wall image acquisition based on generation adversarial network |
| Yuzhuo Gu1, Zongyang Li1, Weiqiong Ma2,3, Guanxun Cheng4, Liwen Wan1, Lei Zhang1, Yongming Dai5, Ye Li1, Dong Liang1, Xin Liu1, Hairong Zheng1, and Na Zhang1 | ||
1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Department of Radiology, Huizhou Central People's Hospital, Huizhou, China, 3Department of Radiology, Guangdong Second Provincial General Hospital, Guangzhou, China, 4Department of Radiology, Peking University Shenzhen Hospital, Shenzhen, China, 5United Imaging Healthcare, Shanghai, China |
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High resolution magnetic resonance vessel wall imaging (MRVWI) is now widely used for the risk evaluation of patients with ischemic stroke. The use of MRVWI with and without contrast agent is a diagnostic criterion from expert consensus recommendations. However, patients with renal insufficiency who receive gadolinium-based contrast agents are at risk for developing a debilitating and potentially fatal disease known as nephrogenic systemic fibrosis. The study proposes a method based on adversarial generation network to obtain enhanced MR vessel wall image without using contrast agent. The results show the enhancement effect is consistent with the contrast-enhanced MRVWI images. |
| 4542 | Booth 1
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Aortic hemodynamics with accelerated dual-venc 4D fow MRI in patients with type B aortic dissection |
| Ozden Kilinc1, Stanley Chu1, Justin Baraboo1,2, Elizabeth K. Weiss1,2, Anthony Maroun1, Ning Jin3, Kelvin Chow1,4, Xiaoming Bi4, Rachel Davids4, Chris Mehta5, S. Chris Malaisrie5, Andrew Hoel6, Michael Markl1,2, and Bradley D. Allen1 | ||
1Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 2Department of Biomedical Engineering, Northwestern University, Chicago, IL, United States, 3Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc., Cleveland, OH, United States, 4Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc., Chicago, IL, United States, 5Division of Cardiac Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 6Division of Vascular Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States |
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4D flow MRI is a well-validated imaging technique for quantitative assessment of blood flow hemodynamics and has shown promise in evaluation of type B aortic dissection (TBAD). However, single velocity encoding (venc) 4D flow MRI is limited by its inability to fully capture wide range of velocities related to variable pathologic hemodynamic patterns such as true lumen and false lumen flow range of velocities in TBAD. We hypothesize that dual-venc acquisition improves velocity-to-noise ratio, better captures full dynamic range of velocities in TBAD and provides improved characterization of flow hemodynamics relative to single-venc acquisitions. |
| 4543 | Booth 2
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Reference value of ascending aorta global longitudinal strain by cardiovascular magnetic resonance feature tracking |
| HongZhou Zhang1,2, Shuang Leng1,3, Ru-San Tan1,3, Ping Chai4,5, Jennifer Bryant1,3, Lynette Teo5,6, Ching Ching Ong4,5, Angela S. Koh1,3, Wen Ruan1, James W. Yip4,5, Ju Le Tan1,3, and Liang Zhong1,3 | ||
1National Heart Centre Singapore, Singapore, Singapore, 2Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China, 3Duke-NUS Medical School, Singapore, Singapore, 4National University Heart Centre, Singapore, Singapore, 5Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 6National University Hospital, Singapore, Singapore |
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This study aimed to introduce a novel parameter—aorta (AO) global longitudinal strain (GLS)—for AO stiffness assessment by semi-automated feature tracking approach with standard cine cardiovascular magnetic resonance (CMR). The data demonstrated excellent intra and inter-observer variability of AO GLS of 4.4% and 5.0%, respectively. AO GLS was significantly negatively associated with age. The mean AO GLS was greater in females (10.1±3.5% versus 8.1±2.7%, P<0.001). The AO GLS decreased by 1.68% in females and 1.32% in males per decade respectively. Age was an independent predictor of the AO GLS in both males and females. |
| 4544 | Booth 3
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Aortic kinetic energy in repaired tetralogy of Fallot patients with or without aortic root dilatation |
| Yu-Ru Yang1, Meng-Chu Chang1, Ming-Ting Wu2, Ken-Pen Weng3, and Hsu-Hsia Peng1 | ||
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 3Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan |
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The aortic hemodynamic flow pattern and aortic kinetic energy (KE) is less discussed for repaired tetralogy of Fallot (rTOF) patients without aortic root dilatation. We aimed to evaluate aortic KE in rTOF patients with or without aortic root dilatation. The rTOF1 patients (indexed aortic root diameter<16 mm/m2) demonstrated aortic regurgitation. Both rTOF1 and rTOF2 (indexed aortic root diameter≥16 mm/m2) patients exhibited normal aortic vorticity and decreased aortic KE. In conclusion, in rTOF patients with preserved left ventricular ejection fraction, the altered velocity-derived KE and RF can provide an indication of aortapathy progress earlier than morphological aortic dilatation and aortic vorticity. |
| 4545 | Booth 4
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Severe Cerebral Small Vessel Disease Burden is Associated with Brain Hypo-perfusion, and higher Framingham Risk score: An 8 year follow-up study |
| Xiaoqian Zhang1, Sirui Liu1, Feng Feng1, and Zhentao Zuo2,3 | ||
1Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 2State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 3Department of Human Anatomy, Histology and Embryology, School of Basic Medicine, Peking Union Medical College, Beijing, China |
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The study investigated relationship between cerebral small vessel disease (CSVD) burden, cerebral blood flow (CBF) and cardiovascular risk in the aging brains with normal cognitive function at baseline and conducted telephone cognitive follow-up for nearly 8 years. The results showed that severe CSVD burden was significantly associated with higher cardiovascular risk scores and decreased CBF in multiple areas, with involvement of nearly all cortical brain areas. Subjects with severe CSVD burden were more likely to suffer from long-term cognitive decline. This suggests the capability of CSVD burden serving as an imaging marker of predicting cognitive decline. |
| 4546 | Booth 5
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Acceleration Motion Compensation Diffusion-weighted Imaging for Large Vessel Vasculitis: Phantom Model and Initial Clinical Experience |
| Tomoko Hyodo1, Daisuke Morimoto-Ishikawa2,3, Hayato Kaida1, Yu Ueda4, Daisuke Tomita5, Atsuhiro Yamamoto5, Makoto Itoh2, Nao Yasuda2, Hiroyuki Fukushima2, Yuji Nozaki5, Itaru Matsumura5, and Kazunari Ishii1 | ||
1Radiology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan, 2Radiology Center, Kindai University Hospital, Osaka-Sayama, Japan, 3Medical Physics and Engineering, Osaka University Graduate School of Medicine, Suita, Japan, 4Philips Japan, Tokyo, Japan, 5Hematology and Rheumatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan |
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The ascending aorta is poorly delineated on DWI due to the heartbeat, making it difficult to assess the activity of large vessel vasculitis using MRI. We investigated the utility of acceleration motion compensation diffusion-weighted imaging (aMC-DWI) compared with conventional DWI (cDWI) to detect active inflammation of the accenting aorta. The phantom experiment revealed that aMC-DWI showed a significantly higher median visual score than cDWI in both experimenters (P =.048 for both). The clinical study on 11 patients showed that aMC-DWI had higher sensitivity, specificity, and positive predictive value (with FDG-PET/CT as the reference method) than cDWI. |
| 4547 | Booth 6
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High-resolution flow-sensitive CINE imaging visualizing valve, chamber, and regurgitant flow |
| Isao Shiina1, Michinobu Nagao2, Masami Yoneyama3, Yasuhiro Goto1, Yutaka Hamatani1, Kazuo Kodaira1, Takumi Ogawa1, Mana Kato1, and Shuji Sakai2 | ||
1Department of Radiological Services, Tokyo Woman's Medical University, Tokyo, Japan, 2Department of Diagnostic imaging & Nuclear Medicine, Tokyo Woman's Medical University, Tokyo, Japan, 3Philips Japan, Tokyo, Japan |
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Cardiac bSSFP CINE imaging is widely used in clinical practice for function and morphological evaluation, but we often experienced situations where it is difficult to visually evaluate blood flow and valves. TFEPI is a flow-sensitive imaging method and can be expected to evaluate blood flow and valves. In this study, we investigate the clinical usefulness of Flow sensitive CINE Imaging using TFEPI. |
| 4548 | Booth 7
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Evaluation of the Instability of Intracranial Aneurysms Wall by Dynamic Contrast-enhanced Magnetic Resonance Imaging and Vessel Wall Imaging |
| Qichang Fu1, Yi Zhang1, Jingliang Cheng1, Sheng Guan2, and Chengcheng Zhu3 | ||
1Department of Magnetic Resonance, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2Department of Interventional Neuroradiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 3Department of Radiology, University of Washington, Washington, WA, United States |
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This study used DCE-MRI and VWI to explore the value of Ktrans and aneurysm wall enhancement (AWE) in screening UIAs instability. Eighty-two patients were enrolled, including 51 patients with stable IAs and 31 patients with unstable IAs. All patients completed examinations based on a 3.0T Siemens Prisma magnetic resonance. Multivariate logistic regression revealed that AWEP (OR, 4.1; 95% CI, 2.06 to 8.16; P < 0.001) and Ktrans (OR, 2.77; 95% CI, 1.49 to 5.17; P = 0.01) were the only independent factors associated with unstable UIAs. Both Ktrans and AWEP were independent risk factors for the unstable state of UIAs. |
| 4549 | Booth 8
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Aneurysmal wall enhancement is positively correlated with inflow angle in sidewall aneurysms |
| Mingzhu Fu1, Fei Peng2, Wenwen Chen1, Aihua Aihua Liu2, and Rui Li1 | ||
1Department of Biomedical Engineering, Tsinghua University, Center for Biomedical Imaging Research, Beijing, China, 2Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Beijing, China |
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In this study, we utilized HR-VWI and 3D TOF-MRA images to investigate the relationship between AWE grades and aneurysm inflow angle. Statistics indicated that the AWE grades were positively associated with the aneurysm inflow angle. This is probably because a sidewall aneurysm with high inflow angle is easier to grow and cause slower inflow velocity and lower wall shear stress which contribute to inflammation processes on aneurysmal wall and lead to a high grade of AWE. The results of this study showed that the AWE was positively associated with aneurysm inflow angle. |
| 4550 | Booth 9
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Assessment of compressed sensing accelerated non-contrast-enhanced whole-heart coronary MR angiography at 3.0 T |
| Wenbo Zhang1, Jingliang zhang Cheng1, Liangjie Lin2, Yong zhang Zhang1, Keyan zhang Wang1, Huiyu zhang Huang1, Qi Ren1, and WenHua Zhang1 | ||
1MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2Philips Healthcare, Beijing, China |
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The feasibility of non-contrast-enhanced coronary MR angiography (CMRA) with acceleration by compressed sensing (CS) was assessed in patients with suspected coronary artery diseases on a 3.0 T scanner, compared with conventional coronary MRA. Results indicate that the whole-heart non-contrast CMRA accelerated by CS with a factor of 4 obtained relatively high sensitivity, positive predictive value, negative predictive value and accuracy in a significantly shortened acquisition time compared with conventional CMRA. |
| 4551 | Booth 10
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Left ventricular blood flow kinetic energy in Hypertensive heart disease ：A pilot study of 4D flow cardiovascular magnetic resonance |
| Kun Peng1, Yong Liu1, Ting Hua1, Xianling Zhang2, Xiance Zhao3, Jilei Zhang3, and Guangyu Tang1 | ||
1Department of Radiology, Shanghai Tenth People’s Hospital, School of Medicine，Tongji University, Shanghai, China, 2Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine，Tongji University, Shanghai, China, 3Philips Healthcare, Shanghai, China |
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Four-dimensional flow magnetic resonance imaging (4D-flow MRI) technique has been developed to assess intra-cavity left ventricular (LV) blood flow. Hypertensive heart disease (HHD) is a common cardiovascular disease and manifested as left ventricular hypertrophy and diastolic/systolic dysfunction. The purpose of this study was to investigate whether 4D-flow CMR kinetic energy (KE) parameters are sensitive to distinguish HHD patients from age/gender-matched healthy controls, and to access if there are significant differences in different sub-groups of LV ejection fraction. We also aimed to investigate the association of LV KE to LV function parameters and LV mass. |
| 4552 | Booth 11
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The Value of Free-breathing 4D-Flow MRI in Children with Extrahepatic Portal Venous Obstruction: A Preliminary Study |
| Huiying Wu1, Ning Zhou1, Zhe Wen2, Lianwei Lu1, Mingjie Zhang1, Fuyu You2, Tao Liu2, Yunzhu Wu3, and Xiaochun Zhang*1 | ||
1Radiology, Guangzhou Women and Children’s Medical Center, Guangzhou, China, 2Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou, China, 3MR Scientific Marketing, Siemens Healthineers, Guangzhou, China |
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This preliminary study has investigated the feasibility of free-breathing 4D-flow MRI to evaluate portal hemodynamics in children with EHPVO. Free-breathing 4D-flow MRI is feasible and hopeful for the comprehensive 3D visualization and quantification of portal vein flow dynamics in 14 children and the peak velocity had similar diagnostic efficiency to ultrasound in our study. In the future, we intend to compare 4D-flow parameters with intraoperative manometry of the portal vein system and use the noninvasive radionics methodology to estimate portal vein hemodynamics in children. |
| 4553 | Booth 12
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Association of Aortic Wall Characteristics and Cardiac Function in Fontan Patient |
| Yu-Cheng Lin1, Ming-Ting Wu2, Ken-Pen Weng3, and Hsu-Hsia Peng1 | ||
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 3Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan |
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The interaction of aortic wall characteristics and cardiac function in Fontan patients is unclear. 4D flow MRI was employed to quantify the wall shear stress (WSS) and oscillatory shear index (OSI) in the aorta. Fontan patients exhibited increased axial WSS, decreased axial OSI and non-roundness of WSS in descending aorta (DAo). We also found that the increased axial WSS in DAo correlated with decreased ejection fraction and increased indexed end-systolic volume. The cardiac dysfunction presented adverse interaction with aortic wall characteristics in patients with Fontan, especially in DAo, and might lead to higher risk of atherosclerosis and stenosis. |
| 4554 | Booth 13
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Clinical application of 3.0T whole-heart non-contrast agent MRCA by using Compressed SENSE |
| XianKuo Hu1, Yang Zhang2, XiaoHu Li3, Yu Shan Yuan2, Bin Peng1, and YuanYuan Li2 | ||
1Fuyang People's Hospital, fuyang, China, 2Fuyang People's Hospital, FuYang, China, 3the First Affiliated Hospital of Anhui Medical University, hefei, China |
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MR Coronary angiography (MRCA) technology can observe the anatomical morphology of coronary arteries and detect lumen stenosis, dilation, and abnormal wall lesions [1]. MRCA technology is relatively complex with long scanning time [2]. Compressed SENSE (CS) technology can greatly shorten the scanning time and improve the rate of succussed examination. This study aim to explore the clinical feasibility of Compressed SENSE technology in non-contrast agent MRA and explore the best acceleration factor of CS. |
| 4555 | Booth 14
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Motion-resolved 4D Real-time Flow MRI |
| Aiqi Sun1, Bo Zhao2, Yichen Zheng3, Yuliang Long4, Peng Wu5, and He Wang1,6 | ||
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 2University of Texas at Austin, Austin, TX, United States, 3Beijing PINS Medical Co., Ltd, Beijing, China, 4Department of Cardiology, Zhongshan hospital Fudan University, Shanghai, China, 5Philips Healthcare, Shanghai, China, 6Human Phenome Institute, Fudan, Shanghai, China |
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Conventional 4D flow MRI requires electrocardiogram gated cine acquisition and respiration control to measure flow dynamics associated with one synthetic cardiac cycle. This often leads to low acquisition efficiency and also cannot resolve beat-by-beat nor respiratory-related flow variations. This work presents a new 4D real-time flow MRI method which is able to simultaneously resolve respiratory and cardiac motion. Compared to conventional 4D flow MRI, the proposed method well captures the beat-by-beat flow variations and respiration-related flow dynamics. Its feasibility for aortic flow was demonstrated in several healthy subjects and also patients with atrial fibrillation. |
| 4556 | Booth 15
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Assessments of hemodynamic changes in abdominal aortic aneurysm in patients using 4D EPI flow MRI |
| Wen Zeng1, Chunchao Xia1, Xiaoyong Zhang2, and Zhenlin Li1 | ||
1West China Hospital, Sichuan University, Chengdu, China, 2Clinical Science, Philips Healthcare, Chengdu, China, Chengdu, China |
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Four-dimensional flow MRI (4D flow MRI) plays a significant role in cardiovascular imaging, which provides new insights into the pathophysiology of disease. In this study, 4D flow with echo-planar imaging was introduced to evaluate the hemodynamic parameters of patients with abdominal aortic aneurysm, including velocity, flow and wall shear stress. We propose that 4D EPI flow can find differences of the above parameters between abdominal aortic aneurysm and normal abdominal aorta and has potential to be used for hemodynamics assessment in AAA patients. |
| 4557 | Booth 1
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Evaluation of cardiotoxicity in chest tumor patients receiving immune checkpoint inhibitors by cardiovascular magnetic resonance |
| Jia Liu1, Yukun Cao1, Kuikui Zhu1, Sheng Yao2, Mei Yuan1, Xiangchuang Kong1, Xiaoming Liu1, Yumin Li1, Yue Cui1, Xiaoyu Han1, Xiaoyue Zhou3, Rui Meng1, and Heshui Shi1 | ||
1wuhan union hospital, wuhan, China, 2wuhan tongji hospital, wuhan, China, 3Siemens Healthcare, shanghai, China |
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In our study, we conducted a prospective study to investigate the subclinical cardiotoxicity by serial cardiovascular magnetic resonance (CMR) in patients receiving immune checkpoint inhibitor (ICI). Some functional parameters and global strains of bi-ventricles revealed significant decrease at the early stage on ICI therapy, and ejection fraction as well as global strain values of both ventricles all showed a decline trend. Tissue characterization is an extra advantage of CMR technique. While in our study, parameters (T1 mapping, T2 mapping and late gadolinium enhancement) regarding tissue characterization of global myocardium showed no significant differences, compared with baseline data. |
| 4558 | Booth 2
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Correlation between LV fractal dimension and impaired strain in patients with excessive trabeculation and normal LV ejection fraction |
| Shiqin Yu1, Xiuyu Chen1, Kai Yang1, Jiaxin Wang1, Kankan Zhao2, Wenhao Dong1, Weipeng Yan1, and Shihua Zhao1 | ||
1Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 2Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, SZ University Town, Shenzhen, China |
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In patients with prominent excessive trabeculation, left ventricular systolic dysfunction was detected early by cardiac MRI feature tracking despite the presence of normal left ventricular ejection fraction and was associated with excessive trabecular complexity assessed by fractal dimension. |
| 4559 | Booth 3
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Dynamic MRI Reconstruction Combining Tensor Nuclear Norm and Casorati Matrix Nuclear Norm |
| Yinghao Zhang1, Yue Hu1, and Xin Lu2 | ||
1School of Electronics and Information Engineering, Harbin Institute of Technology, Harbin, China, 2School of Computer Science and Informatics, De Montfort University, Leicester, United Kingdom |
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Low-rank tensor models have been applied in accelerating dynamic magnetic resonance imaging (dMRI). Recently, a new tensor nuclear norm based on t-SVD has been proposed and applied to tensor completion. Inspired by the different properties of the tensor nuclear norm (TNN) and the Casorati matrix nuclear norm (MNN), we introduce a novel dMRI reconstruction method combining TNN and Casorati MNN, which we term as TMNN. Moreover, we convert the the TMNN dMRI reconstruction problem into a simple tensor completion problem, which can be efficiently solved by the alternating direction method of multipliers (ADMM). |
| 4560 | Booth 4
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Native T1 mapping texture analysis discriminates hypertensive heart disease vs non-apical hypertrophic cardiomyopathy |
| Mei Yuan1, Jia Liu1, Huan Liu2, Xiaoyue Zhou3, and Heshui Shi1 | ||
1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2GE Healthcare, Shanghai, China, 3Siemens Healthineers Ltd., Shanghai, China |
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本研究探索了原生T1映射的纹理分析（TA），以便检测非apic肥大性心肌病（HCM）、心肌梗塞和高血压心脏病（HHD）的特定模式，具有良好的诊断效果，可反映心肌纤维化。结果表明，TA能够有效地区分和显示与心脏功能相媲美的诊断精度，并结合菌株分析。TA、心脏功能和应变分析的结合，使非 apical HCM 或 apical HCM 与 HHD 的区分具有最佳诊断精度。这表明，将 TA 与心脏功能和应变参数相结合，比单独使用 TA 具有增量值。 |
| 4561 | Booth 5
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Left Ventricular Strain is associated with Outcomes of Pulmonary Valve Replacement in Patients with Repaired Tetralogy of Fallot |
| Baiyan Zhuang1, Minjie Lu1, and Shihua Zhao1 | ||
1Fuwai Hospital, State Key Laboratory of Cardiovascular Disease，PUMC, Beijing, China |
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Given the fact that patients who have underwent repair of tetralogy of fallot (rTOF) further need pulmonary valve replacement (PVR) due to pulmonary regurgitation, but the effect of PVR is mixed. We prospectively enrolled 45 asymptomatic rTOF patients who required PVR due to moderate or severe pulmonary regurgitation and measured their pre-operative strain and strain rate. After follow-up and analysis, we found that the radial strain (RS), circumferential strain (CS), longitudinal strain (LS), systolic radial strain rate (RSRs), early diastolic radial strain rate (RSRe) and early diastolic longitudinal strain rate (LSRe) before PVR are important prognostic factors for adverse events. |
| 4562 | Booth 6
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Improvement of distortion-free cardiac IVIM-DWI using motion-compensated single-shot turbo spin echo DWI with fast elastic image registration |
| Yasuhiro Goto1, Nagao Michinobu2, Masami Yoneyama3, Johannes M Peeters4, Isao Shiina1, Kazuo Kodaira1, Yutaka Hamatani1, Takumi Ogawa1, Mana Kato1, and Shuji Sakai2 | ||
1Department of Radiological Services, Tokyo Woman's Medical University, Tokyo, Japan, 2Department of Diagnostic imaging & Nuclear Medicine, Tokyo Woman's Medical University, Tokyo, Japan, 3Philips Japan, Tokyo, Japan, 4Philips Healthcare, Best, Netherlands |
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We evaluated the feasibility of the combined use of MoSE CINE imaging (to determine exact TD as a preparation procedure), MoCo-TSE-DWI acquisition and FEIR post-processing (to register the respective diffusion images) for improving the robustness of quantitative cardiac IVIM mapping. Combined use of the MoSe-CINE procedure for determining the exact cardiac trigger delay, MoCo-TSE-DWI acquisition, and FEIR post-processing to register among all source images, could be useful to increase the robustness of image quality and improve the quantitative accuracy in myocardial IVIM mapping. |
| 4563 | Booth 7
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Feasibility of fractal analysis in the diagnosis of hypertrophic cardiomyopathy patients using strain analysis as reference |
| xin Zhang1, Lianggeng Gong1, jingyang Wen1, long Qian2, and Weiyin Vivian Liu2 | ||
1The Second Affiliated Hospital of Nanchang University, Nanchang, China, 2MR Research, GE Healthcare, Beijing, China |
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Pathological changes vary in the morphology and function during the process of hypertrophic cardiomyopathy. In this study, we compared the diagnostic value of fractal analysis and tissue tracking on cardiovascular magnetic resonance images to characterize the trabecular complexity as myocardial strain alteration for HCM. |
| 4564 | Booth 8
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Non-linear Association Between NT-proBNP and Septal Native T1 in Non-ischaemic Dilated Cardiomyopathy |
| Yujie Gao1, Xiaoyue Zhou2, Shengen Liao3, and Yi Xu1 | ||
1Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2MR Collaboration, Siemens Healthcare, Shanghai, China, 3Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China |
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This study investigated the relationship between cardiac magnetic resonance (CMR) T1 mapping parameters and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in non-ischaemic dilated cardiomyopathy (DCM) patients. The results showed that, in DCM, a non-linear relationship existed between NT-proBNP and septal native T1, indicating a complex relationship between the secretion of NT-proBNP and myocardial diffuse fibrosis. When NT-proBNP is greater than the inflection point(1105 pg/ml), NT-proBNP may provide additional value for the judgment of myocardial diffuse fibrosis. |
| 4565 | Booth 9
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Simultaneous late-gadolinium enhancement and T1 mapping to detect diffuse myocardial fibrosis in 1K/DOCA/salt-induced mice using MP2RAGE |
| Gang Zheng1, Yifang Li2, Ekaterina Salimova 1, Hong X Wang1, Shenjun Zhong 1, Chrishan S Samuel 2, Michael de Veer1, and Gary Egan 1 | ||
1Monash Biomedical Imaging, Monash University, Clayton, Australia, 2Monash Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, Australia |
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The detection and localization of diffuse myocardial fibrosis is for the non-invasive evaluation of therapeutic strategies in murine cardiac disease models. Cardiac late-gadolinium enhancement (LGE) and T1 mapping are two techniques for non-invasive cardiovascular magnetic resonance (CMR) imaging. This abstract demonstrates that the magnetization prepared 2 rapid acquisition gradient echo (MP2RAGE) can simultaneously acquire LGE and T1 maps for the detection of diffuse myocardial fibrosis in a 1K/DOCA/salt-induced murine model of hypertensive disease. |
| 4566 | Booth 10
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Clinical assessment of high spatial resolution myocardial T2-weighted dark blood imaging based on deep learning |
| Lingping Ran1, Lu Huang1, Xianghu Yan1, Yi Luo1, Shuheng Zhang2, Shiyu Zhang2, Yuan Zheng3, Jian Xu3, and Liming Xia1 | ||
1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2United Imaging Healthcare, Shanghai, China, 3UIH America, Inc., Houston, TX, United States |
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High resolution T2-weighted dark blood (HR-T2W-DB) imaging is not always robust for clinical use because of low SNR and long scan time. The purpose of this study was to evaluate a novel deep learning (DL) based reconstruction method in T2W-DB sequence that achieves higher spatial resolution and same scan duration compared with traditional reconstruction method. Quantitative and qualitative image assessment demonstrated that DL based HR-T2W-DB sequence showed better CNR in region of edema and LV free wall visibility, which might help detecting myocardial edema. |
| 4567 | Booth 11
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Deep-learning for automatic assessment of paradoxical movement in left ventricular aneurysm after myocardial infarction using CMR cine imaging |
| Binghua Chen1, Jilei Zhang2, Weibo Chen2, Yihong Zhang2, Jianrong Xu1, and Lianming Wu1 | ||
1Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 2Philips Healthcare, Shanghai, China |
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We propose an automatic diagnostic model for left ventricular aneurysm after myocardial infarction. A epicardium segmentation model was established by mixing 2- and 3-chamber images of 90 healthy volunteers, and the dice in all cohorts exceeded 0.95. Five heartphaseimages around end-systolic and end-diastolic stages, multiplied by the predicted mask using the segmentation model were used as the input of the classification model. Data from 259 AMI patients were divided into training cohort (206) and independent testing cohort (53). ResNet was selected to extract the features of 2- and 3- chamber data. Finally, AUC achieved on 0.987/0.946 in training and testing cohort. The automtic deep learning model can be used as a scheme to dignose LVA after AMI, and has potential clinical value for early detection of the risk of the ventricular aneurysm in AMI patients. |
| 4568 | Booth 12
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The predictive value of intravoxel incoherent motion in the assessment of adverse cardiovascular events of athletes heart |
| Yujiao Deng1,2 and Jing Chen2 | ||
1Department of Nuclear Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, chengdu,sichuan, China, 2Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China |
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Regular exercise can have a beneficial effect on the cardiovascular system, but more and more reports of sudden cardiac deaths in athletes and general people during exercise had made people gradually pay attention to the damage effect of exercise on the heart.There is currently lack of imaging examination methods for early and accurate judgment of athletes’ myocardial injury.This study intended to use intravoxel incoherent motion diffusion-weighted imaging to evaluate the myocardial microcirculation of athletes to early predict the incidence of adverse cardiac events such as cardiac remodeling and delayed enhancement of the myocardium. |
| 4569 | Booth 13
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Prediction of the changes in myocardial of patients with cardiomyopathy using T1rho mapping |
| Fang Wang1, Zhen Zhang1, Xiuzheng Yue2, Xiaowei Ruan1, Rongrong Zhu1, Ruoshui Ha1, and Yanbin Yang1 | ||
1Medical Imaging Center, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, China, 2Philips Healthcare, Beijing, China |
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The study is to determine clinical utility of T1rho to detect patients with cardiomyopathy. In the LGE positive group, the T1 mapping values and ECV values in the lesion area were significantly higher than those in the LGE negative group and the normal control group, while the T1rho values in the lesion area were significantly lower than those in the LGE negative and normal groups, and the display range of lesions was in good consistency with LGE and ECV. It can be used as an endogenous diagnostic index when myocardial structure changes. |
| 4570 | Booth 14
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The Clinical value of Left ventricle and Septum for Right ventricular function in Patients with Left Ventricle Acute Myocardial Infarction |
| Yanan Zhao1, Tao Li1, Jianing Cui1, Xueqian Liu2, and Xiuzheng Yue3 | ||
1Department of Radiology, Chinese People’s Liberation Army General Hospital, Beijing, China, 2Qinhuangdao Workers' Hospital, Qinhuangdao, China, 3Philips Healthcare, Beijing, China |
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The reduced right ventricular ejection fraction (RVEF) has prognostic value for predicting cardiovascular mortality in patients with left ventricular acute myocardial infarction (LVAMI). Previous studies have shown that interaction between left ventricular (LV) and right ventricular (RV). This study used CMR to further explore what factors affect the RVEF. The results shown that the incidence of reduced RVEF was 40% in LVAMI patients and the occurrence of reduced RVEF was associated with LVEF, LV end-systolic volume index and RV end-systolic volume index. |
| 4571 | Booth 15
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High resolution myocardial T1mapping with a deep learning constrained Compressed SENSE reconstruction |
| Takashige Yoshida1, Kohei Yuda2, Masami Yoneyama3, Jihun Kwon3, and Marc Van Cauteren4 | ||
1radiology, Tokyo metropolitan police hospital, Tokyo, Japan, 2Tokyo metropolitan police hospital, Tokyo, Japan, 3Philips Japan, Tokyo, Japan, 4Philips Healthcare, Best, Netherlands |
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High-resolution imaging and T1 mapping is needed to achieve useful clinical information optimally in cardiac MRI. However, prolonged acquisition time can lead to poor or non-diagnostic image quality. In this study, we investigated the use of a deep learning-based reconstruction algorithm to highly accelerate T1map acquisition for cardiac MRI. Adaptive-CS-Net, a deep neural network previously introduced at the 2019 fastMRI challenge, was expanded and integrated into the Compressed-SENSE Artificial Intelligence (CS-AI) reconstruction. The purpose of this study was to compare the image quality of high-resolution T1map between reference and accelerated methods: SENSE, Compressed-SENSE, and CS-AI. |
| 4572 | Booth 1
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Arterial spin labeling estimation of penumbral tissue in acute ischemic stroke |
| Jinhao Lyu1 and Xin Lou1 | ||
1Chinese PLA General Hospital, Beijing, China |
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Penumbral tissue identification is critical for the treatment decision for patients with acute ischemic stroke. In the present study, we aimed to assess the impact of arterial spin labeling (ASL) at different post-labeling delays (PLDs) in penumbral tissue quantification, and compare their performances in patients’ selection for endovascular treatment with dynamic susceptibility contrast as reference. The results showed ASL appears to persistently overestimate penumbral tissue in acute ischemic stroke. PLD shows substantial impact on quantification of hypoperfusion volume. Long PLD, 2500ms for example, is preferable in penumbral tissue detection and patients’ selection. |
| 4573 | Booth 2
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Detection of crossed cerebellar diaschisis in subacute ischemic stroke using 3D PCASL with two post-labeling delay time method |
| Yuelei Lyu1, Hua Gu1, Yanping Xue1, Lizhi Xie2, Tao Jiang1, and Qi Yang1 | ||
1Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China, 2MR Research China, GE Healthcare, Beijing, China |
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This study investigated the feasibility of 3D PCASL to detect crossed cerebellar diaschisis (CCD) in patients with unilateral supratentorial subacute stroke using two PLD method and correlated the ischemic perfusion with CCD to identify the relevant imaging factors of CCD development. 3D PCASL can detect CCD in patients of supratentorial subacute stroke. Patients of supratentorial subacute stroke experience late-arriving flow while CCD+ patients suffer late arriving flow in the affected contralateral cerebellum. CCD+ patients may have a propensity towards more hemodynamic compromise and compensatory collateral flow in the cerebellum. |
| 4574 | Booth 3
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Collateral Circulation Detected by Arterial Spin Labeling Can Predict Outcome in Acute Ischemic Stroke |
| Sangni Liu1, Dandan Fan1, and Chunming Xie1 | ||
1Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China |
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Robust collateral circulation is strongly associated with better outcomes in acute ischemic stroke. In this prospective study, collateral circulation was defined as arterial transit artifact in Arterial Spin Labeling(ASL) images. Patients with ASL collaterals represented higher rate of good outcome and there were significant differences for percent changes of mRS score and NIHSS score between groups. Furthermore, the presence of ASL collaterals could predict good outcome, even after controlling for baseline NIHSS score. Taken together, ASL collaterals provide a powerful tool to predict clinical outcome for acute ischemic stroke with 90 days follow-up. |
| 4575 | Booth 4
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Multi-delay arterial spin labeling perfusion map may predict cerebral hyperperfusion after carotid endarterectomy |
| Xiaoyuan Fan1, Tianye Lin1, Juan Wei2, Jianxun Qu2, Zhentao Zuo1, and Feng Feng1 | ||
1Peking Union Medical College Hospital, Beijing, China, 2GE healthcare, Beijing, China |
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Preoperative measurement of cerebrovascular reactivity using acetazolamide or CO2 induced SPECT is the gold standard for predicting cerebral hyperperfusion (CH) after carotid endarterectomy (CEA). However, it is often impractical to perform SPECT examinations on all patients. Arterial spin labeling (ASL) is a non-invasive technique to image the brain perfusion. Based on multi-delay ASL perfusion map, we extracted two hemodynamic parameters (cerebral blood flow and arterial transit time) and established a five-scale scoring system for the prediction of CH. We found in patients with carotid stenosis, multi-delay ASL is a practical and reliable tool for the prediction of CH after CEA. |
| 4576 | Booth 5
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Clinical utility of intraoperative Arterial Spin Labeling for resection control in brain tumor surgeries, a 3T study. |
| Marta Calvo-Imirizaldu1, Verónica Aramendia-Vidaurreta1,2, Marta Vidorreta3, Reyes García-Eulate1,2, Pablo Domingez Echeverri1,2, Josef Pfeuffer4, Bartolome Bejarano5, Lain Hermes Gonzalez-Quarante5, Antonio Martinez-Simon6, and María Fernández-Seara1,2 | ||
1Radiology, Clínica Universidad de Navarra, Pamplona, Spain, 2IDISNA, Pamplona, Spain, 3Siemens Healthcare, Madrid, Spain, 4Application Development, Siemens Healthcare, Erlangen, Germany, 5Neurosurgery, Clínica Universidad de Navarra, Pamplona, Spain, 6Anesthesia and Intensive Care, Clínica Universidad de Navarra, Pamplona, Spain |
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ASL has shown potential to depict residual tumor compared to anatomical imaging in previous intraoperative MRI (iMRI) study performed at 1.5T. However, the technique has not been evaluated at higher field, where field inhomogeneities could compromise the labeling efficiency. We aimed to assess feasibility and utility of iMRI-ASL at 3T. To that end, a PCASL sequence was evaluated in 10 patients. In one patient ASL depicted an additional high CBF focus indicating neovascularization (known to correlate with higher grade component) that wasn’t depicted in the anatomical images, favoring the use of ASL in the iMRI setting to achieve maximal resection. |
| 4577 | Booth 6
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Does arterial spin labeling provide insights into long-term effects of radiation therapy in the healthy brain? |
| Andrea Kronfeld1, Alexandra Russo2, Nicole Henninger2, Arthur Wingerter2, Moritz Brunk2, Kaml Khawaja1, Andrei Tropine1, Abdulghani Moussa Pacha1, Violeta Dimova3, Federico Marini4,5, Doris Leithner6, Sabine Nospes7, Roman Kloeckner8, Felix Hahn8, Marcus Stockinger9, Heinz Schmidberger9, Marc Brockmann1, Marie Astrid Neu2, Joerg Faber2, and Yasemin Tanyildizi1 | ||
1Neuroradiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, 2Pediatric Hematology, Oncology & Hemostaseology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, 3Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, 4Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, 5Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, 6Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany, 7Otolaryngology, Head and Neck Surgery, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, 8Diagnostic and Interventional Radiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, 9Radiation Oncology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany |
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28 patients after earlier (1-45 years) whole brain radiation and 22 healthy controls were examined by arterial spin labeling to discover insights ASL could give in long-term effects of radiation therapy in the healthy brain. Relative cerebral blood flow and relative bolus arrival time showed increased values compared to the healthy control, which could be a sign for increased permeability and thickening of the vessels, two well described effects of radiation therapy ASL gives insight into. |
| 4578 | Booth 7
|
A study on MRI arterial spin labeling in predicting early response to chemoradiotherapy in patients with advanced nasopharyngeal carcinoma |
| zongqiong sun1 and Weiqiang Dou2 | ||
1Department of radiology, Affiliated hospital of Jiangnan university, Wuxi, China, 2GE healthcare,MR research China, Beijing, China |
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This study mainly investigated the feasibility of 3D pseudo-continuous arterial spin labeling (3D-pCASL) imaging in predicting the treatment response to chemoradiotherapy (CRT) for advanced nasopharyngeal carcinoma (ANPC) patients. 3D-pCASL derived blood flow (BF)s in tumors were respectively obtained for patients in response group (RG) and no-response group (NRG). The resultant pre-treatment BF showed significantly different values between RG and NRG patients. Combining with clinical information, BF also showed robust prediction between RG and NRG patients. Therefore, 3D-pCASL could be considered an effective method in tumor response prediction to CRT for ANPC patients before clinical treatment. |
| 4579 | Booth 8
|
ATP-A safe stressor for stress perfusion cardiac magnetic resonance |
| Huihui Kong1, Jing An2, Jiaxin Cao3, Jinfan Tian4, Jingwen Yong4, Xiantao Song4, and Yi He3 | ||
1Radiology, Beijing Friendship Hospital, Beijing, China, 2Siemens Healthcare, Beijing, China, 3Beijing Friendship Hospital, Beijing, China, 4Beijing Anzhen Hospital, Beijing, China |
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This study investigated the side effects and safety of ATP as a stressor for stress perfusion cardiac magnetic resonance. The result showed the high safety of stress perfusion with ATP and side effects were mild and resolved shortly after receiving ATP. Furthermore, it was also observed splenic switch-off that can be used to assess stress adequacy undergoing stress-CMR with ATP. |
| 4580 | Booth 9
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Comparison of different denoising approaches for DCE-MRI |
| Zejun Wang1, Bao Wang2, Ziyi Huang3, Yingchao Liu4, and Ruiliang Bai1,5 | ||
1Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, 2Department of Radiology, Qilu Hospital of Shandong University, Jinan, China, 3College of Life Sciences, Zhejiang University, Hangzhou, China, 4Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, 5Department of Physical Medicine and Rehabilitation, Interdisciplinary Institute of Neuroscience and Technology, The Affiliated Sir Run Run Shaw Hospital, School of Medicine,, Zhejiang University, Hangzhou, China |
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The physiological parameters estimated from pharmacokinetic modeling of DCE-MRI are usually biased by the non-white, spatially-dependent noise. In this study, we compared several state-of-arts denoising approaches, including gaussian low pass filter (GLPF), the dynamic nonlocal mean (DNLM), the nonlocal mean based on spatiotemporal patches (NLM-ST), 2D and 3D kinetics-induced bilateral filter (KIBF). Our results reveal that the 3D KIBF can reduce the noise significantly and reserve subtle information best. |
| 4581 | Booth 10
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Revealing Occult Hemodynamic Signatures from the Acetazolamide-Augmented Cerebral BOLD Response |
| Siddhant Dogra1, Xiuyuan Wang2, Jelle Veraart1, Alejandro Gupta1, Koto Ishida3, Deqiang Qiu4, and Seena Dehkharghani1,3 | ||
1Department of Radiology, New York University Langone Health, New York, NY, United States, 2Department of Radiology, Weill Cornell Medicine, New York, NY, United States, 3Department of Neurology, New York University Langone Health, New York, NY, United States, 4Department of Radiology, Emory University, Atlanta, GA, United States |
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Acetazolamide-augmented blood-oxygen-level-dependent (ACZ-BOLD MRI) provides robust estimation of cerebrovascular reactivity (CVR). Past approaches are limited to extraction of terminal CVR at arbitrarily selected times in the pharmacologic response, due to low signal-to-noise characteristics. We previously introduced a computational framework that pre-conditions the BOLD response for dynamic analysis and extraction of maximal, rather than terminal augmentation profiles, and novel hemodynamic signatures such as ACZ-BOLD time-to-maxima (Tmax). Several consistent and sometimes paradoxical patterns have emerged, the presentation of which we considered timely for this potentially novel hemodynamic neuroimaging biomarker. |
| 4582 | Booth 11
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Correlation Analysis between BOLD Delay and Cerebral Blood Flow: A Study in Moyamoya Patients |
| Zhangxuan Hu1, Zhe Zhang2,3, Yuanren Zhai4, Long Qian1, Binbin Sui2,3, and Dong Zhang4 | ||
1GE Healthcare, Beijing, China, 2Tiantan Neuroimaging Center of Excellence, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 3China National Clinical Research Center for Neurological Diseases, Beijing, China, 4Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China |
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It has been shown that the BOLD delay calculated from resting-state fMRI can reveal perfusion information. In this study, the correlation between BOLD delay and CBF measured from ASL were explored. The results showed the inter-subject correlation between BOLD delay and CBF values. Meanwhile, the inter-group differences of the correlation coefficients between Moyamoya patients and healthy controls were also compared. |
| 4583 | Booth 12
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Are cerebral microvascular perfusion and diffusion dynamics associated with neurological function in acute ischemic stroke? |
| Fei Chen1, Zhenyu Dai1, Lizheng Yao1, Congsong Dong1, Haicun Shi2, and Weiqiang Dou3 | ||
1Department of Radiology, the Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng, China, 2Department of Neurology, the Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng, China, 3GE Healthcare, MR Research China, Beijing, China |
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This work explored the association of cerebral microvascular perfusion and diffusion dynamics measured by intravoxel incoherent motion (IVIM) imaging with initial neurological function and clinical outcome in acute stroke patients. Significant negative correlations were revealed between IVIM derived diffusion dynamics parameters and initial neurological function as well as clinical outcome for patients with acute ischemic stroke. However, no similar statistical correlation was found for parameters related to microvascular perfusion. IVIM may be therefore suggested as an effective non-invasive method for evaluating the initial neurological function and clinical outcome in acute ischemic stroke. |
| 4584 | Booth 13
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Characterization of mouse cerebrovascular reactivity using task-free resting-state fMRI |
| Yixi Xue1, Russell W. Chan1,2, Sarah Y. Wu1, Emily L. Tse1, Muneeb A. Faiq1, Thajunnisa A. Sajitha1, and Kevin C. Chan1,3 | ||
1Department of Ophthalmology, New York University Grossman School of Medicine, New York, NY, United States, 2Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, United States, 3Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States |
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The recent development of relative cerebrovascular reactivity (rCVR) mapping derived from task-free resting-state blood-oxygenation-level-dependent fMRI resolves issues of experimental complications from hypercapnic challenge or pharmacological administrations required in conventional CVR mapping. While human clinical rCVR studies have begun, there lacks rCVR characterization in healthy adult rodents before it can be applied to preclinical models of neuropathology for translational research. This study demonstrated the feasibility of rCVR mapping using resting-state fMRI at 7 Tesla in mice. The results also revealed potential rCVR lateralization in cortical regions and heterogenous vascularization along the septotemporal axis of the hippocampus. |
| 4585 | Booth 14
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Cerebrovascular Reactivity Mapping using General Linear Model in Frequency Domain |
| Botian Xu1, Chau Vu1, Matthew Borzage2, and John Wood2 | ||
1University of Southern California, Los Angeles, CA, United States, 2Children's Hospital Los Angeles, Los Angeles, CA, United States |
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Cerebrovascular reactivity (CVR), measuring the ability of vessel dilation or constriction, is an important indicator of cerebrovascular health. As a parameter describing the hemodynamic changes, CVR requires a physiological challenge as the stimulus and monitors the response of the brain metabolism. We propose a frequency-based approach, which applies general linear model (GLM) on the magnitude of the stimulus and response spectrum to avoid challenges with signal alignment and improve robustness to noise in CVR estimation. |
| 4586 | Booth 15
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Improve the Image Quality of Arterial Spin Labeling with Echo Planar Imaging with Compressed SENSE |
| Chunqiu Su1, Xiance Zhao2, Jilei Zhang2, Xunning Hong1, and Shanshan Lu1 | ||
1Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2Philips Healthcare, Shanghai, China |
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Arterial spin labeling (ASL) is a non-invasive MRI perfusion technique that can quantify tissue blood flow, which is meaningful for clinical applications. However, ASL perfusion images always have a limited signal-to-noise ratio (SNR). We aimed to using the echo planar imaging with compressed SENSE (EPICS) to obtain high-quality brain ASL images. Eleven healthy subjects and four patients with intracranial infarction were enrolled, and underwent ASL imaging with and without EPICS. The results demonstrated the feasibility of EPICS to increase the quality of ASL images. |
| 4587 | Booth 1
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The impact of hemodynamic patterns and geometric features of vertebra-basilar system on atherosclerotic plaque occurrence |
| Rui Shen1, Hualu Han1, Jinmei Zheng2, Huiyu Qiao1, Zihan Ning1, Xinyu Tong3, Yunjing Xue4, and Xihai Zhao1 | ||
1Center for Biomedical Imaging Research, Tsinghua University, Beijing, China, 2Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China, 3Department of Biomedical Engineering, School of Life and Science, Beijing Institute of Technology, Beijing, China, 4Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China |
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This study investigated the relationship between the geometry of vertebra-basilar system and hemodynamic measurements and presence of BA plaques. We found that geometric measurements and most hemodynamic features were significantly correlated with the occurrence of BA plaque (mean curvature, r=0.368; NOR-TAWSS-NF, r=-0.312; SAR-OSI-NF, r=0.290; NOR-TAWSS-nNF, r=-0.387; NOR-OSI-nNF, r=0.440). There were significant differences in mean curvature, hemodynamic characteristics of Newtonian flow and non-Newtonian flow models between patients with and without BA plaque. Our study indicated that geometric features and non-Newtonian flow model-based hemodynamic measurements are risk factors of BA plaque. |
| 4588 | Booth 2
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High prediction accuracy for functional outcome of acute ischemic stroke using nomogram based on clinical factors and radiomics features |
| Yiran Zhou1, Guiling Zhang1, Wenzhen Zhu1, and Weiyin Vivian Liu2 | ||
1Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology, Wuhan, China, 2GE Healthcare, Beijing, China |
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To develop a nomogram for accurate prediction of acute ischemic stroke (AIS) outcome, 522 AIS patients were retrospectively selected in this study. Radiomics features were extracted from DWI and ADC maps and radiomics score was established. Logistic regression analysis was implemented to sift independent clinical factors and construct prediction model. Finally, the nomogram incorporated age, sex, stroke history, diabetes, baseline modified Rankin Scale, baseline National Institutes of Health Stroke Scale score and radiomics score yield the great predictive performance with an AUC-ROC of 0.868 in training cohort and 0.890 in validation cohort, the AUC-PR reached 0.733 and 0.787 respectively. |
| 4589 | Booth 3
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Imaing the brain microstructures in patients of severe enlarged perivasclar spaces in the basal ganglia region using diffusion kurtosis imaging |
| Yuelei Lyu1, Shuna Yang1, Chen Zhang2, Qinglei Shi2, Guang Yang3, Wenli Hu1, and Qi Yang1 | ||
1Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China, 2MR Scientific Marketing, Siemens Healthineers, Beijing, China, 3Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, China |
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This study used DKI to investigate possible microstructural alterations of brain tissues associated with plenty of EPVS in the basal ganglia (BG) in patients of SVD. Our preliminary results revealed that patients with EPVS in the BG showed significant reductions in kurtosis parameters from DKI and elevated diffusion parameters derived from DKI in bilateral putamen. We also found abnormal diffusion parameters in mainly bilateral BG, limbic system, temporal lobe,and other scatter brain regions. Our data suggests patients with plenty of EPVS in the BG might undergo microstructure impairments in the regions above, especially bilateral insular and BG. |
| 4590 | Booth 4
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Association between antiplatelet therapy and cerebral microbleeds determined by susceptibility weighted imaging in stroke-free pupolation |
| Miaoxin Yu1, Yanan Jia2, Dandan Yang3, Runhua Zhang1, Yong Jiang1, Guitao Zhang1, Huiyu Qiao4, Hualu Han4, Rui Shen4, Zihan Ning4, Xihai Zhao4, and Gaifen Liu1 | ||
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases, Beijing, China, 2Department of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China, 3Department of Radiology, Beijing Geriatric Hospital, Beijing, China, 4Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China |
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In this cross-sectional, observational study, we investigated the association between antiplatelet therapy and cerebral microbleeds (CMBs) in community-based participants without stroke. The presence, count, and location of CMBs were evaluated by susceptibility weighted imaging. Antiplatelet therapy included aspirin use alone, clopidogrel use alone, cilostazol use alone, and dual antiplatelet therapy with aspirin and clopidogrel. We found that antiplatelet therapy was independently associated with CMBs at any location, particularly lobar CMBs, and aspirin use was a risk factor for any CMB and lobar CMBs. Our study suggests that optimizing antiplatelet treatment strategies in stroke-free population may decrease the risk of CMBs. |
| 4591 | Booth 5
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Altered Spontaneous Brain Activity Related to Neurologic Dysfunction in Patients with Cerebral Small Vessel Disease: A resting-state study |
| Mengmeng Feng1, Hongwei Wen2,3, Haotian Xin1, Changhu Liang4, and Lingfei Guo4 | ||
1Shandong Provincial Hospital, Jinan, China, 2Key Laboratory of Cognition and Personality (Ministry of Education), Chongqing, China, 3Southwest University, Chongqing, China, 4Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China |
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Cerebral small vessel disease (CSVD) patients can present structural and functional abnormalities. We divided 102 subjects into three groups and obtained information about altered spontaneous brain activity using amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF) and regional homogeneity (ReHo) methods based on resting-state functional MRI. Compared with controls and the CSVD without cerebral microbleeds (CSVD-n) group, the CSVD with cerebral microbleeds (CSVD-c) group showed significantly increased ALFF/ReHo values and decreased fALFF values in some brain regions, which are correlated to abnormal clinical characteristics. These results expounded the underlying neurophysiological mechanisms in CSVD patients. |
| 4592 | Booth 6
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Arterial transit artifact could prognose stroke patients beyond 24 hours from last known well |
| Di Wu1, Shun Zhang2, Weiyin Vivian Liu3, and Wenzhen Zhu4 | ||
1Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, 2Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, 3GE Healthcare, Beijing, China, Beijing, China, 4Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China |
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The study aimed to assess the correlation of arterial transit artifact (ATA) with clinical outcomes and collateral circulation status in stroke patients beyond 24 hours from last known well. ATA is assessed by 3-dimentional pseudo-continuous ASL (3D-pCASL), collateral status by magnetic resonance angiography (MRA) using a grading system from 0 to 3, and clinical outcomes by 3-month modified Ranking Scale (3m-mRS). ATA was present in about half of the enrolled patients, most of whom had large artery disease. Though the correlation between ATA and the degree of collateral supply was not statistically significant, ATA could predict the favorable clinical outcomes. |
| 4593 | Booth 7
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Preliminary study on plaque characteristics in young adults with symptomatic intracranial atherosclerotic stenosis |
| Ling Li1, XiaoLing Zhang1, Xiaoyan Lei1, Min Tang1, Xuejiao Yan1, and Kai Ai2 | ||
1Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China, 2Philips Healthcare, Xi'an, China |
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This study used high-resolution magnetic resonance imaging (HRMRI) to explore plaque characteristics of young adults with symptomatic intracranial atherosclerotic stenosis (sICAS). Compared with old patients, young patients with sICAS have a smaller Maximum wall thickness and a greater ability to reconstruct, and are more prone to positive remodeling, which may cover up some patients with atherosclerotic stenosis. The results show great clinical importance for a better understanding of youth intracranial arterial plaque features and highlights the importance of HRMRI. |
| 4594 | Booth 8
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MRI Radiomics approach for Identification of high-risk intracranial plaque basing on machine learning |
| Haining Wei1, Fang Wu2, Jie Lu2, and Rui Li1 | ||
1Tsinghua University, Beijing, China, 2Xuanwu Hospital, Capital Medical University, Beijing, China |
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Intracranial atherosclerotic disease (ICAD) is one of the main causes of ischemic stroke. Increasing evidence supports that vulnerable plaque is correlated with risk for stroke, which reveals the importance of intracranial plaque risk identification. Radiomics is an automated and repeatable approach for extracting massive features for medical imaging. However, few articles have focused on radiomic-based studies of intracranial plaque of basilar artery and middle cerebral artery. In this study, we propose to build a high-risk intracranial plaque model using radiomics features and machine learning to differentiate symptomatic plaque from asymptomatic plaque, which is helpful in guiding clinical management. |
| 4595 | Booth 9
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A 72-channel coil system for MR vessel wall imaging of intracranial and carotid arteries at 3 T |
| Yingchao Tan1,2,3, Qiaoyan Chen1,2, Qian Zou3, Yanling Chen3, Junyu Chen3, Xin Liu1,2, Hairong Zheng1,2, and Ye Li1,2 | ||
1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, Shenzhen, China, 3Shanghai United Imaging Healthcare, Shanghai, China |
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MR vessel wall imaging of intracranial and carotid arteries is still challenging because of the small cross-sectional size of the vessel wall and the cord, and susceptibility effects, especially in the carotid and the spinal cord. In this study, a 72-channel coil system that consists of a 64-channel head coil combined with an 8-channel carotid coil was proposed and characterized in its performance by comparison with a 40-channel coil system. As a result, the proposed 72-channel coil system provides improved performance in SNR, parallel imaging capability, and image quality. |
| 4596 | Booth 10
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Accuracy of Characterizing Carotid Vulnerable Atherosclerotic Plaque by 3D MR Vessel Wall Imaging: A Histological Validation Study |
| Chenlin Du1, Zihan Ning1, Huiyu Qiao1, Shuo Chen1, Tao Wang2, Jingli Cao3, Huo Ran4, Dongye Li5, Chunjiang Hu1, Shuwan Yu1, Hualu Han1, Rui Shen1, Dandan Yang1,6,7, Cancheng Liu8, Peng Wu9, and Xihai Zhao1 | ||
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, 2Department of Neurosurgery, Peking University Third Hospital, Beijing, China, 3China National Clinical Research Center for Neurological Disease, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 4Department of Radiology, Peking University Third Hospital, Beijing, China, 5Department of Radiology, Sun Yat-Sen Memorial hospital, Sun Yat-Sen University, Guangzhou, China, 6Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China, 7Department of Radiology, Beijing Geriatric Hospital, Beijing, China, 8Thorough Images, Beijing, China, 9Philips Healthcare, Shanghai, China |
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This study investigated the accuracy of 3D multi-contrast MR vessel wall imaging (VWI) in characterizing carotid vulnerable plaque compositions including lipid-rich necrotic core (LRNC), intraplaque hemorrhage (IPH) and calcification (CA) validated by histology. Good agreements were found between MR and histology in identifying LRNC (κ=0.67), IPH (κ=0.66), and CA (κ=0.62) after excluding histological sections with the plaque components <1.77 mm2. Moderate agreements were reached in quantifying plaque compositions with r values ranged from 0.46 to 0.61 (LRNC: r=0.52; IPH: r=0.6; CA: r=0.46). Our study demonstrated that 3D multi-contrast MR VWI is capable of accurately characterizing carotid vulnerable atherosclerotic plaques. |
| 4597 | Booth 11
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3D Large-Coverage Simultaneous QUantitative T1-T2-T2* Mapping (LC-SQUMA) of Carotid Vessel Wall |
| Huiyu Qiao1, Qiansu Yang2, Shuo Chen1, Zihan Ning1, Hualu Han1, Rui Shen1, Peng Wu3, Huijun Chen1, and Xihai Zhao1 | ||
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine Tsinghua University, Beijing, China, 2Center of Medicine Clinical Research, Department of Pharmacy, Medical Supplies Center of PLA General Hospital, Beijing, China, 3Philips Healthcare, Shanghai, China |
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MR T1-, T2-, and T2*- mapping have been used to characterize carotid plaques. In this study, we realized a 3D Large-Coverage (longitudinal coverage: 160 mm) Simultaneous QUantitative T1-T2-T2* Mapping (LC-SQUMA) sequence with 0.8 mm isotropic spatial resolution. The LC-SQUMA sequence showed excellent agreements with reference imaging in measuring T1 (R2=0.96), T2 (R2=0.85) and T2* (R2=0.90) values. No significant difference was found in measuring T1, T2 and T2* values (all P>0.05) of cervical muscle between LC-SQUMA sequence and clinical referenced quantitative imaging sequences. The 3D LC-SQUMA sequence is feasible in the large-coverage carotid vessel wall quantitative imaging with isotropic spatial resolution. |
| 4598 | Booth 12
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Quantitative analysis of Symptomatic and Asymptomatic Atherosclerotic Middle Cerebral Artery Plaques Using 7T Magnetic Resonance Imaging |
| Xiaoyan Bai1, Qingle Kong2, Zhiye Li1, Pingping Fan1, and Binbin Sui3 | ||
1Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing Neurosurgical Institute, Beijing, China, Beijing, China, 2MR Collaboration, Siemens Healthineers Ltd., Beijing, China, Beijing, China, 3Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing, China, Beijing, China |
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A total of 40 MCA atherosclerotic plaques of 34 patients (20 symptomatic and 20 asymptomatic plaques) were quantitatively analyzed of plaque features including plaque burden, length, remodeling index, plaque distribution, and surface morphology using 7T vessel wall Magnetic Resonance Imaging (VW-MRI). Compared with the asymptomatic plaques, symptomatic MCA plaques had larger plaque length and higher plaque burden. Superior-wall distribution and irregular plaque surface were observed more commonly on the symptomatic MCA plaques. 7T VW-MRI is a promising method to evaluate the atherosclerotic plaque features at MCAs. |
| 4599 | Booth 13
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Deep Learning regularized SPIRiT reconstruction accelerates joint intracranial and carotid vessel wall imaging into 3.5 minutes |
| Sen Jia1, Jing Cheng1, Zhuoxu Cui2, Lei Zhang1, Haifeng Wang1, Xin Liu1, Hairong Zheng1, Hongying Zhang3, and Dong Liang1,2 | ||
1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Shenzhen, China, 2Research Center for Medical AI, Shenzhen Institutes of Advanced Technology, Shenzhen, China, 3Northern Jiangsu People's Hospital, Yangzhou, China |
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Deep learning regularized SPIRiT reconstruction is developed by unrolling the conventional L1-SPIRiT optimization solved by the projection onto convex sets (POCS) iteration into a multi-layer convolutional neural network. The learnable network regularization with 3D convolution improved the reconstruction accuracy and efficiency compared with the iterative L1-SPIRiT with 2D sparsity regularization in a fixed transform domain. The simplicity of POCS iteration also benefits the design complexity of the DL-SPIRiT network. The proposed DL-SPIRiT could accelerate the joint intracranial and carotid vessel wall imaging of isotropic 0.6 mm resolution by 8-fold, leading to a scan time of only 3.5 minutes. |
| 4600 | Booth 14
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Using fMRI to compare physiotherapy and yoga-induced changes in post-stroke rehabilitation |
| Dushyant Kumar1, Rajesh Mishra1, Chahat Kumar2, Priyanka Bhagat2, Padma Srivastava2, and Rama Jayasundar1 | ||
1NMR, All India Institute of Medical Sciences, Delhi, India, 2Neurology, All India Institute of Medical Sciences, Delhi, India |
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This study has compared using fMRI, the changes effected by physiotherapy and yoga in post-stroke recovery. Ischemic stroke patients (n=20) with motor deficits were divided into two groups - yoga and physiotherapy. Each group practiced yoga or physiotherapy for one hour daily for six months, under the supervision of certified yoga trainers and physiotherapists, respectively. Pre- and post- (6 months) intervention evaluations were carried out using fMRI at 3T and NIHSS scores. Results show significant improvement in the NIHSS scores and BOLD activity in the affected sensory motor region of the stroke patients in the yoga group compared to physiotherapy. |
| 4601 | Booth 15
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High-resolution compressed sensing TOF-MRA might show better performance than CTA for evaluating revascularization in Moyamoya patients |
| Shujing Ren1, Wei Wu2, Chunqiu Su1, Qianmiao Zhu2, Michaela Schmidt3, Yi Sun4, Christoph Forman3, Peter Speier3, Xunning Hong1, and Shanshan Lu1 | ||
1Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 3Siemens Healthcare, Erlangen, Germany, 4Siemens Healthcare, Shanghai, China |
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It is important for MMD patients to receive repeated life-time follow-up examinations for evaluation of bypass patency and collateral formation from neovascularization after bypass surgery. In this study we evaluated the clinical value of high-resolution (0.4 × 0.4 × 0.4 mm3 isotropic) CS TOF-MRA for assessment of STA-MCA bypass and neovascularization by using CTA as the reference. We found that high-resolution CS TOF-MRA could provide better visualization for both STA-MCA bypass and neovascularization than traditional CTA within a clinically reasonable time in MMD patients after surgical revascularization. |
| 4602 | Booth 16
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Assessment of cerebrovascular related tissue pH in patients with moyamoya disease: an amide proton transfer weighted imaging study |
| Chao Xia1,2, Jiaxin Zeng1,2, Xia Wei1,2, Ziyu Li1,2, Yuan Sun1,2, Na Hu1,2, Yi Liu3, Kai Ai4, and Su Lui1,2 | ||
1Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, 2Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China, 3Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China, 4Philips Healthcare, Xi'an, China |
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The amide proton transfer weighted (APTw) imaging was used to investigate the collateral circulation change and pH alteration in patients with moyamoya disease (MMD). Thirteen patients underwent computed tomography perfusion (CTP), digital subtraction angiography (DSA), and APTw imaging. We analyzed the difference in APTw values between the cerebral and cerebellar hemispheres. Then subgroup analysis was conducted according to the stage of preinfarction period based on CTP. The results revealed that APTw values were significantly lower in cerebral hemispheres than those in cerebellar hemispheres. However, no significant difference in APTw values among patients with different stages of preinfarction period was found. |
| 4603 | Booth 17
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Mapping functional connectivity and brain network changes in hypertensive using resting-state fMRI |
| Yu-Chen Chuang1,2, Wen-Chau Wu1,3, Vincent Chin-Hung Chen4,5, Yen-Hsuan Hsu6, and Jun-Cheng Weng2,5,7 | ||
1Institute of Medical Device and Imaging, Graduate Institute of Clinical Medicine, National Taiwan University, Taipei city, Taiwan, 2Department of Medical Imaging and Radiological Sciences, Graduate Institute of Artificial Intelligence, Chang Gung University, Taoyuan, Taiwan, 3Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, 4School of Medicine, Chang Gung University, Taoyuan, Taiwan, 5Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, 6Department of Psychology, National Chung Cheng University, Chiayi, Taiwan, 7Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan |
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Although understanding of the relationship between cardiovascular disease and brain dysfunction has improved significantly over the past decades, it remains unclear whether hypertension can be a potential risk factor for cognitive impairment. This study tried to use resting-state fMRI to explore the association between hypertensive (HTN) and brain function alterations. We found significant differences in the DMN subsystems in HTN group compared with control group. We also observed higher assortativity in HTN group. |
| 4604 | Booth 1
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Reduced Blood Brain Barrier Water Exchange and Cerebral Blood Flow in CARASIL Patients Revealed by Perfusion MRI: a pilot study |
| Huiru Pan1,2, Yingying Li3, Huilou Liang1,2, Tingyan Yao4, Xingfeng Shao5, Xuejia Jia3, Zihao Zhang1,2,6, Zhentao Zuo1,2,6, Jing An7, Danny JJ Wang5, Rong Xue1,2,8, and Qi Yang3 | ||
1Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2University of Chinese Academy of Sciences, Beijing, China, 3Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China, 4Department of Neurology, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China, 5Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 6The Innovation Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Beijing, China, 7Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China, 8Beijing Institute for Brain Disorders, Beijing, China |
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We applied 3D diffusion-prepared pseudo-continuous arterial spin labeling (DP-pCASL) to evaluate water exchange rate (kw) of blood brain barrier (BBB) and its association with clinical characteristics of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) patients. The CARASIL group showed significantly decreased kw and cerebral blood flow (CBF) compared with healthy controls. The association between kw with age, CBF and white matter hyperintensity volumes (WMH) found in CARASIL patients suggest that kw could be a potential non-contrast imaging biomarker for BBB dysfunction in cerebral small vessel disease. |
| 4605 | Booth 2
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A Hybrid-Two-Compartmental-Model for the Blood-Brain-Barrier Assessment of Glioma Patients |
| Dinil Sasi S1, Rakesh Kumar Gupta2, Rana Patir2, Suneeta Ahlawat2, and Anup Singh1,3 | ||
1Center for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, 2Fortis Memorial Research Institute, Gurugram, India, 3All India Institute of Medical Sciences New Delhi, New Delhi, India |
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Dynamic-contrast-enhanced (DCE)-MRI has shown wide potential in characterizing brain tumor. Conventionally, generalized-tracer-kinetic-model (GTKM) and Patlak-model (PM) have been widely used in clinics to characterize the blood-brain-barrier (BBB) integrity of the tumor. However, PM is recommended for DCE-MRI data with shorter duration (less than 1 minute) and GTKM may overfit in non-enhancing and normal tissues causing erroneous estimation of extra-vascular volume fraction (ve). So, the current study proposes a hybrid tissue depended model with maximum 2 model fitting parameters by combining GTKM and PM depending on underlying tissue. Proposed model has outperformed GTKM in all tissue regions. |
| 4606 | Booth 3
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Assessment of Cerebral Perfusion in Moyamoya Disease with Dynamic pCASL using a Variable-TR scheme with Optimized Background Suppression |
| Osamu Togao1, Makoto Obara2, Kazufumi Kikuchi3, Tatsuhiro Wada4, Chiaki Tokunaga4, Ryoji Mikayama4, Shingo Baba3, Marc Van Cauteren5, Akio Hiwatashi3, and Kousei Ishigami3 | ||
1Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2Philips Japan, Tokyo, Japan, 3Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 4Division of Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 5Philips Healthcare, Tokyo, Japan |
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The aim of the present study was to determine whether the dynamic pCASL using a variable-TR scheme with optimized background suppression is useful for assessing cerebral perfusion in patients with Moyamoya disease by comparing with 123I-IMP SPECT. ASL dynamic data at 10 time points are acquired by changing the label duration and post label delay. Significant correlations were found between SPECT-CBF and ASL-CBF and between arterial transit time (ATT) and cerebrovascular reactivity (CVR) to acetazolamide challenge on SPECT. ATT was significantly longer in areas where the CVR was decreased than in areas where the CVR was maintained. |
| 4607 | Booth 4
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Histogram-based analysis of perfusion features in oligodendrogliomas using multi-delay arterial spin labeling MR imaging: a preliminary study |
| Huilou Liang1,2, Lianwang Li3,4, Shengyu Fang3,4, Yinyan Wang3,4, Yuchao Liang3,4, Zeshan Yao5, Jing An6, Yan Zhuo1,2,7, Lei Wang3,4, Lijuan Zhang8, Danny JJ Wang9, and Rong Xue1,2,10 | ||
1State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2University of Chinese Academy of Sciences, Beijing, China, 3Beijing Neurosurgical Institute, Beijing, China, 4Department of Neurosurgery, Beijing Tiantan Hospital, Beijing, China, 5AnImage Tech. Beijing Co., Ltd., Beijing, China, 6Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China, 7CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Beijing, China, 8Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 9Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 10Beijing Institute for Brain Disorders, Beijing, China |
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The clinical treatment and prognosis of oligodendrogliomas are closely related to the histopathological grade. As a non-invasive and non-contrast perfusion imaging technique, arterial spin labeling (ASL) has been widely used in studies of glioma grading. The estimation of cerebral blood flow (CBF) in conventional single-delay ASL can be affected by the arterial transit time (ATT) effect. Here, multi-delay 3D ASL providing multiple hemodynamic parameters including ATT and ATT-corrected CBF was used to analyze the histogram-based perfusion features in oligodendrogliomas. Our results showed no difference in rCBF between WHO grade 2 and 3 oligodendrogliomas, but prolonged rATT in higher grade oligodendrogliomas. |
| 4608 | Booth 5
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Auto-calibrated Mutiband First-pass Perfusion Imaging with CS reconstruction in patients with suspect CAD at 3T MRI |
| Lixian Zou1,2, Jialing Chen3, Yuan Zheng4, Yu Ding4, Yubao Liu3, Jian Xu4, Hairong Zheng1,2, and Xin Liu1,2 | ||
1Paul C. Lauterbur Research Centre for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Science, Shenzhen, China, 2Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen, China, 3Medical Imaging Center, Shenzhen Hospital, Southern Medical University, Shenzhen, China, 4UIH America Inc., Houston, TX, United States |
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A whole heart perfusion imaging with auto-calibrated multiband CAIPIRINHA with through-time encoding and iterative reconstruction (tMB+CS-FPP) has been proposed to acquire multiple slices simultaneously without extra reference scans. The technique can achieve perfusion images with doubled anatomic coverage with identical spatial resolution. In this study, we compared the performance of the tMB+CS-FPP using different k-t undersampling patterns in a phantom study. And the proposed method was performed to the patients with suspect CAD and was compared to the conventional FPP. |
| 4609 | Booth 6
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Towards clinical perfusion imaging at 5T using 3D ASL |
| Yan Tong1, Qing Wei2, and Jun Xie2 | ||
1Shenzhen United Imaging Research Institute of Innovative Medical Equipment Innovation Research, Shenzhen, China, 2United Imaging Healthcare, Shanghai, China |
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Arterial spin labeling (ASL) benefits from both increased intrinsic SNR and reduced T1 relaxation time at higher field strength. However, the implementation of ASL at 7T is challenging, primarily due to increased SAR, and B1+/B0 inhomogeneity. Recently, United Imaging Healthcare introduced a 5T whole-body scanner. 5T might be a superior field strength for ASL due to the improved SNR compared to 3T, and less severe B1+/B0 inhomogeneity and reduced SAR compared to 7T. This study demonstrated the feasibility of high-resolution ASL at 5T, and the results showed superior SNR compared to 3T. |
| 4610 | Booth 7
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Altered dynamic cerebral perfusion during recovery in right hemisphere subcortical stroke |
| Peifang Miao1, Caihong Wang1, Ying Wei1, Jingliang Cheng1, and Kaiyu Wang2 | ||
1The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2GE Healthcare MR Research, Beijing, China, Beijing, China |
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To quantify cerebral blood flow (CBF) dynamic evolution and the relationship with clinical outcomes during recovery in right subcortical stroke patients,ASL and neurological examinations were performed repeatedly in 25 patients at 4 time points and 26 healthy controls (HCs) once.One-way Within-Subjects ANOVA and two sample test,pearson correlation analyses were performed.Compared with HCs, patients displayed continuous crossed cerebellar diaschisis.Increased CBF of contralesional sensorimotor cortex in the subacute and chronic are vital for recovery.Patients showed dynamic changes of CBF in contralesional cerebellum superior and occipital lobe,which were negatively correlated with memory.Findings provide a theoretical basis for functional impairment and recovery after stroke. |
| 4611 | Booth 8
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Effects of vascular territories on the efficiency of DANTE preparation pulse for ASL |
| Shota Ishida1, Hirohiko Kimura2, Naoyuki Takei3, Yasuhiro Fujiwara4, Tsuyoshi Matsuda5, and Nobuyuki Kosaka2 | ||
1Department of Radiological Technology, Faculty of medical sciences, Kyoto College of Medical Science, Nantan, Japan, 2Department of Radiology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan, 3GE Healthcare, Tokyo, Japan, 4Department of Medical Image Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, 5Division of Ultra-high Field MRI, Institute for Biomedical Science, Iwate Medical University, Shiwa-gun, Japan |
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This study aimed to assess whether the efficiency of DANTE, a vascular suppression in ASL, is affected by vascular territories. CBF, transit times (TT), and their rates of change were determined in nine vascular territories from the proximal to distal regions. Although CBF reduction rates were not different among the territories, TT extension rates were lower in the distal region than in other regions. No correlation was observed between TT extension and CBF reduction rates. DANTE efficiency is not affected by transit time or vascular territories. Homogenous vascular suppression effects could be obtained by DANTE-ASL. |
| 4612 | Booth 9
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Improved Dynamic contrast in Motion Corrected Dynamic Contrast Enhancement MRI Using Low Rank with Soft Weighting and Joint sparsity |
| Jichang Zhang1, Xinpei Wang1, Faisal Najeeb2, Pengfei Xu1, Hammad Omer2, Penny Gowland3, Sue Francis3, Paul Glover3, Richard Bowtell3, and Chengbo Wang1 | ||
1SPMIC, The University of Nottingham Ningbo China, Ningbo, China, 2COMSATS University Islamabad, Islamabad, Pakistan, 3SPMIC, The University of Nottingham, Nottingham, United Kingdom |
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This work presents a motion corrected free breathing Dynamic Contrast Enhanced MRI (DCE-MRI) with improved dynamic contrast reconstruction method called L+S with soft weighting and joint sparsity. Soft weighting achieves accurate motion correction at expense of dynamic contrast. An additional temporal Fast Fourier Transform (FFT) constraint is used to recover the dynamic contrast. A simulated phantom dataset was created with ground truth in this work, enabling quantification of the motion correction and dynamic contrast performance. The proposed method achieved improved dynamic contrast, better motion correction and high reconstruction efficiency simultaneously. |
| 4613 | Booth 10
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Evaluate myocardial microcirculation in pediatric myocarditis patients with free breathing intravoxel incoherent motion MR sequence |
| Shilan Li1, Jiahuan Tao1, Jing Zhang1, and Kai Ai2 | ||
1Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China, 2Philips Healthcare, Xi’an, China |
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To explore the possibility of application of free breathing intravoxel incoherent motion (IVIM) imaging in pediatric myocarditis patients, we utilized diaphragmatic navigation technique to detect heart rate and improved the probability of scanning success. Eight pediatric myocarditis patients and ten healthy volunteers were enrolled. The study confirmed that the IVIM imaging method with free breathing condition was acceptable and achievable. Besides, compared with healthy children, the microcirculation of myocarditis patients was impaired, and pseudo-diffusion coefficient (Dfast) and perfusion fraction (f) were significantly lower. |
| 4614 | Booth 11
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Comparison of time-encoded and sequential variable-TR scheme for multi-delay pseudo-continuous arterial spin labeling |
| Makoto Obara1, Osamu Togao2, Lena Vaclavu3, Tatsuhiro Wada4, Chiaki Tokunaga4, Ryoji Mikayama4, Hiroshi Hamano1, Matthias van Osch3, Kim van de Ven5, and Marc Van Cauteren6 | ||
1Philips Japan, Tokyo, Japan, 2Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences,, Kyushu University, Fukuoka, Japan, 3C.J. Gorter center for high field MRI, department of Radiology,, Leiden University Medical Center, Leiden, Netherlands, 4Division of Radiology, Department of Medical Technology,, Kyushu University Hospital, Fukuoka, Japan, 5Philips Healthcare, Best, Netherlands, 6Philips Healthcare, Tokyo, Japan |
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There are two approaches proposed to calculate cerebral blood flow (CBF) and arterial transit time (ATT) accurately, while ensuring sufficient SNR. One is time-encoded (TE) and the other is sequential variable-TR (vTR) pseudo-continuous arterial spin labeling (PCASL). In this study, we measured SNR, CBF, and ATT from these two methods and compared and verified their validity in 5 healthy subjects. The higher SNR was secured in TE-PCASL compared to vTR-PCASL. On the other hand, ATT calculated from vTR-PCASL showed higher correlation coefficient with reference compared with TE-PCASL. The CBF calculated from both schemes showed high correlation coefficient with reference. |
| 4770 | Booth 1
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Validation of Beat Sensor Cardiac Triggering against ECG Cardiac Triggering in both Volunteer and Patient Cohorts |
| Yue Pan1,2, Juliet Varghese1, Ning Jin3, Carmel Hayes4, Peter Speier4, Rizwan Ahmad2,5, and Orlando Simonetti1,2,6 | ||
1Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United States, 2Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States, 3Siemens Medical Solutions USA, Malvern, PA, United States, 4Siemens Healthcare GmbH, Erlangen, Germany, 5Department of Electrical and Computer Engineering, The Ohio State University, Columbus, OH, United States, 6Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States |
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In this study, the performance of Beat Sensor Cardiac (BSC) triggering was qualitatively and quantitatively compared with electrocardiogram (ECG) triggering. MR images typically acquired in a comprehensive exam including localizer, morphology, cine, 2D flow, parametric mapping and late gadolinium enhancement (LGE) were acquired using both BSC and ECG triggering in volunteers and patients. The overall image quality for BSC was equivalent to ECG. Quantitative measurements of function, flow, and parametric maps in healthy volunteers showed no significant differences except for peak aortic velocity. |
| 4771 | Booth 2
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CMR Risk Stratification for Dilated Cardiomyopathy with LVEF≥35%: Cohort Study with a Midterm Follow-up |
| Shuang Li1, Wenjing Yang1, Di Zhou1, Yining Wang1, Xiaohan Fan1, Arlene Sirajuddin2, Andrew E. Arai2, Shihua Zhao1, and Minjie Lu1 | ||
1fuwai hospital, Beijing, China, 2National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, United States |
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This study aims to identify the risk factors for adverse events in dilated cardiomyopathy (DCM) patients with LVEF≥35% and establish a scoring model to predict adverse event risk. 269 consecutive DCM patients with LVEF ≥35% who underwent gadolinium-enhanced cardiac magnetic resonance (CMR) imaging were enrolled in this study. The primary endpoint was a composite of SCD or aborted SCD. Secondary endpoints were all-cause mortality, heart transplantation and hospitalization for heart failure. The nomogram we created using these parameters provides a novel way to clinically assess and risk stratify this patient population. |
| 4772 | Booth 3
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Cardiac MRF Using Rosette Trajectories for Simultaneous Myocardial T1, T2, and Proton Density Fat Fraction Mapping |
| Yuchi Liu1, Jesse Hamilton1,2, Yun Jiang1,2, and Nicole Seiberlich1,2 | ||
1Department of Radiology, University of Michigan, Ann Arbor, MI, United States, 2Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States |
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This work aims to extend rosette cardiac MRF to enable simultaneous myocardial T1, T2, and PDFF mapping from a single scan. The accuracy of rosette cMRF in T1, T2, and PDFF quantification is validated in the ISMRM/NIST system phantom and an in-house built fat fraction phantom, respectively. Studies in healthy subjects show that rosette cMRF potentially enables more accurate T1 and T2 measurements than spiral cMRF in the myocardium due to reduced fat contamination. |
| 4773 | Booth 4
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Relationship between Microvascular Obstruction and Regional Myocardial Strain by CMR after ST-segment-elevation Myocardial Infarction |
| Yanan Zhao1, Jianing Cui1, Xueqian Liu2, Tao Li1, and Xiuzheng Yue3 | ||
1Department of Radiology, Chinese People’s Liberation Army General Hospital, Beijing, China, 2Qinhuangdao Workers' Hospital, Qinhuangdao, China, 3Philips Healthcare, Beijing, China |
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Effective risk assessment and stratification are essential for the clinical management of ST-segment elevation myocardial infarction (STEMI) patients. CMR imaging has become a beneficial imaging modality to assess myocardial morphology, function and infarct characteristics simultaneously. This study quantitatively evaluated relationship between microvascular obstruction and regional myocardial strain by Cardiac MRI after ST-segment-elevation myocardial infarction. Our data showed that regional strain parameters may be s new noninvasive imaging markers allowing comprehensive evaluation regional myocardium deformation. |
| 4774 | Booth 5
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Cardiac Quantitative Susceptibility Mapping for Mitral Annular Calcium: Validation using Quantitative Calcium Scoring on Computed Tomography |
| Pablo Villar-Calle1, Jiahao Li2, Alice Saffioti1, Justin Johannesen1, Katherine Tak1, Rachel Meier1, Jiwon Kim1, Quynh A Truong3, Yi Wang2, Pascal Spincemaille3, and Jonathan W Weinsaft1 | ||
1Medicine, Weill Cornell Medicine, New York NY, United States, New York, NY, United States, 2Meinig School of Biomedical Engineering, Cornell University, Ithaca NY, United States, New York, NY, United States, 3Radiology, Weill Cornell Medicine, New York NY, United States, New York, NY, United States |
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This study tested cardiac MRI cardiac quantitative susceptibility mapping (QSM) for measurement of mitral annular calcification (MAC) using the reference of computed tomography (CT). QSM entailed a free-breathing ECG-triggered multi-echo 3D GRE sequence with diaphragmatic navigation via ECG-gating (1D respiratory navigator, 4mm window, acquisition time ~7 minutes, navigator efficiency 36%, spatial resolution 1.5×1.5×5mm3). Among 24 patients undergoing MRI and CT (mean 3.9±3.4 months), annular susceptibility decreased stepwise (p<0.001) and R2* increased (p<0.05) among patients stratified by CT mitral annular calcium score. Both QSM (AUC=0.950, p=0.005) and R2* (AUC=0.938, p=0.007) yielded excellent diagnostic performance for advanced mitral annular calcification on CT. |
| 4775 | Booth 6
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A NOVEL OPEN-SOURCE CARDIAC SEGMENTATION FRAMEWORK FOR CINE MRI |
| Manuel A. León1, Rodrigo Salas1, Sergio Uribe2,3,4,5, and Julio Sotelo1,3,5 | ||
1School of Biomedical Engineering, Universidad de Valparaíso, Valparaíso, Chile, 2Department of Radiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, 3Millennium Nucleus in Cardiovascular Magnetic Resonance, CardioMR, Santiago, Chile, 4Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile, 5Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile |
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Cardiac contour delineation currently presents several proposals for automatic segmentation in short-axis MRI. However, most of them have drawbacks such as low accuracy with images from other MRI scanners, lack of description of the algorithms, and difficult access for clinical or research use. For this reason, we present VENTSEG, a deep learning framework for cardiac segmentation implemented in Matlab and Python. Our dice coefficient results segmenting images from the CNN validation set are 85.55% and 96.17% on anonymized clinical data. These results demonstrate the generalization of the framework on multidomain images. |
| 4776 | Booth 7
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Auto-calibrated Multiband Retrospective GRE Cine at 5T with Improved Reconstruction |
| Yuan Zheng1, Lele Zhao2, Zhongqi Zhang1, Junpu Hu2, Yu Ding1, and Jian Xu1 | ||
1UIH America, Inc, Houston, TX, United States, 2Shanghai United Imaging Healthcare Co. Ltd, Shanghai, China |
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GRE sequences benefit from increased SNR at high field and do not suffer from banding artifacts / SAR issues as bSSFP sequences. We have implemented an autocalibrated multiband retrospective GRE Cine sequence at 5 T. The autocalibrated multiband acquisition increases the efficiency of the sequence by reducing the scan time and simplifying the multiband imaging workflow. A compressed sensing reconstruction with implicit phase interpolation and temporal TV periodic boundary condition were implemented to further improve image quality. We have evaluated this application on volunteers and achieved high quality GRE Cine images. |
| 4777 | Booth 8
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Development of a Prospectively Motion Corrected Free-breathing FLASH Sequence |
| Graeme Harris1, Stephen Jermy1,2, and Ernesta Meintjes1,2 | ||
1Department of Human Biology, Division of Biomedical Engineering, University of Cape Town, Cape Town, South Africa, 2Cape Universities Body Imaging Center, University of Cape Town, Cape Town, South Africa |
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Respiratory motion of the heart is a fundamental challenge to cardiac MR imaging (CMR), frequently compensated for with breath-holding and acceptance-window methods. These methods are not always viable and result in inefficient acquisitions, creating longer scan times1. Here, an adaptive Kalman-filter with a control system was implemented in a FLASH sequence to update the position of the slice during the imaging segment based on repeated navigator measurements acquired during the non-imaging segment. This predictive tracking results in a free-breathing sequence which is less strenuous for subjects, more efficient and reduces scan times. |
| 4778 | Booth 9
|
Myocardial stress field from combined CMR and FEM in ALL survivors |
| Mehdi Ghafarinatanzi1 | ||
1Polytechnique Montréal, Montreal, QC, Canada |
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The objective of this study is to investigate the myocardial 3D strain stress field of the patient-specific left ventricles in children with acute lymphoblastic leukemia (ALL) after treatment. The virtual field-finite element approach is applied to the 3D mesh generated tetrahedral for each patient-specific geometry over the cardiac cycle. The results illustrate the difference in distribution stress and displacement field for each LV subject. |
| 4779 | Booth 10
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Improved myocardial T1 mapping accuracy with Deep Learning reconstruction of low flip angle MOLLI series |
| Gaspar Delso1, Pablo García-Polo2, Margarita Gorodezky3, Ben Ariff4, Vicente Martínez de Vega5, and Javier Urmeneta6 | ||
1GE Healthcare, Barcelona, Spain, 2GE Healthcare, Madrid, Spain, 3GE Healthcare, London, United Kingdom, 4Imperial College Healthcare NHS Trust, London, United Kingdom, 5Servicio de diagnóstico por la imagen, Hospital Universitario Quirónsalud, Madrid, Spain, 6Servicio de cardiología, Hospital Universitario Quirónsalud, Madrid, Spain |
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In this study, we explore the possibility of leveraging Deep Learning regularized reconstruction to enable lower flip angle MOLLI acquisition for myocardial T1 mapping. It has been shown in the past that lowering flip angle helps reduce various artifact sources, at the cost of lower signal to noise ratio. Regularized reconstruction can effectively manage image noise as well as increase feature sharpness. This hypothesis has been tested on a group of clinical patients referred for a cardiac MR exam. |
| 4780 | Booth 11
|
Neural style transfer: Applications in cardiac MR image registration |
| Alper Ozan Turgut1, Matthew Van Houten2, Junyu Wang2, Xue Feng2, and Michael Salerno3 | ||
1School of Medicine, University of Virginia, Charlottesville, VA, United States, 2Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 3Department of Medicine and Radiology, Stanford University, Stanford, CA, United States |
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Contrast-enhanced cardiac magnetic resonance (CMR) stress perfusion imaging shows excellent utility in evaluating coronary artery disease1. Registering perfusion CMR image series is difficult due to the varying image contrast. Neural style transfer is a deep learning method used to transfer the “style” of one domain to another while preserving the content. Two neural style transfer networks were implemented in Python using TensorFlow and PyTorch. Training of each network was done using three, slice matched patient profiles and cine-like perfusion images were generated and registered. This method is compared to a KL-transform based registration approach. |
| 4781 | Booth 12
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Biplane Area-length Method Underestimates 3D Left Atrial Volume in Patients with Atrial Fibrillation |
| Anthony Maroun1, Justin Baraboo1, Suvai Gunasekaran1, Julia Hwang1, Sophia Liu1, Daniel Kim1, Philip Greenland2, Rod Passman3, Bradley Allen1, Michael Markl1, and Maurice Pradella1,4 | ||
1Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, 2Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, 3Department of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, 4Department of Radiology, University Hospital Basel and University of Basel, Basel, Basel, Switzerland |
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The biplane area-length method is routinely used in clinical settings for left atrial volume (LAV) estimation. This technique is time-resolved but relies on geometrical assumptions of an ellipsoidal shape to estimate the LAV. In contrast, quantification derived from 3D segmentations on late gadolinium-enhanced magnetic resonance imaging and contrast-enhanced magnetic resonance angiography are static but do not rely on geometric assumptions. We compared the LAV estimation from these 3 methods in patients with atrial fibrillation and found a significant underestimation by the biplane area-length technique, indicating that this method may not capture the entire LAV in patients with complex anatomy. |
| 4782 | Booth 13
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Improving Accuracy of Myocardial T1 Estimation in MyoMapNet |
| Rui Guo1, Zhensen Chen2, Amine Amyar1, Hossam El-Reiwady1, Patrick Pierce1, Beth Goddu1, and Reza Nezafat1 | ||
1Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States, 2Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China |
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MOLLI T1 mapping is routinely used for myocardial tissue characterization. Despite excellent precision, MOLLI has great T1 underestimation and a long breath-holding time. We previously developed a deep learning-based approach (MyoMapNet) for myocardial T1 mapping using four T1-weighted images. MOLLI T1 was used to train a fully connected neural network (FC), which resulted in a similar accuracy error as MOLLI. In this study, numerically simulated and phantom signals with the presence of different B0, flip angles, and heart rates were used to improve MyoMapNet T1 accuracy. Evaluation showed that MyoMapNet T1 could be improved and had higher precision than SASHA. |
| 4783 | Booth 1
|
Cartesian dictionary-based T1 and T2 mapping of the myocardium |
| Markus Henningsson1 | ||
1Linköping University, Linköping, Sweden |
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A method for simultaneous T1 and T2 mapping of the myocardium is proposed, termed Multimapping, based on dictionary matching using a simple Cartesian single-shot acquisition across 10 cardiac cycles. The method is evaluated in a phantom, 12 healthy subjects and 43 patients with suspected cardiomyopathy. |
| 4784 | Booth 2
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B0 shimming for 7T cardiac T2*-weighted MRI in large animals: practical demands and hardware limitations. |
| Maxim Terekhov1, David Lohr1, Michael Hock1, Maya Bille1, Julia Aures1, Ibrahim A. Elabyad1, Florian Schnitter2, Wolfgang Bauer2, Ulrich Hofmann2, and Laura M. Schreiber1 | ||
1Chair of Cellular and Molecular Imaging, Comprehensive Heart Failure Center, University Hospital Würzburg, Comprehensive Heart Failure Center, Wuerzburg, Germany, 2Department of Internal Medicine I, Cardiology, University Hospital Würzburg, Wuerzburg, Germany |
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Cardiac MRI with T2*-contrast at 7T is of particular interest because it is highly sensitive to cardiac tissue alterations after myocardial injury. A reliable T2*-contrast quantification and usage for tissue characterization require minimization of the inhomogeneity of the B0-field in the heart. In this work, we analyzed the B0-conditions achievable in longitudinal T2* measurements in the hearts of domestic pigs which during the experiment grew from 30 to 90 kg. B0 distribution statistics were summarized for the maps of individual slices. Demands on the 7T-scanners B0-shimming hardware (up to 3rd-order spherical harmonics) were analyzed. |
| 4785 | Booth 3
|
Automated Time Adjusted Inversion Time Selection for Late Gadolinium Enhancement Imaging - Validation and Application on Patient Datasets |
| Seung Su Yoon1,2, Michaela Schmidt2, Manuela Rick2, Teodora Chitiboi3, Puneet Sharma3, Tilman Emrich4,5, Christoph Tillmanns6, Andreas Seitz7, Heiko Mahrholdt7, Solenn Toupin8, Théo Pezel9,10, Jérôme Garot9, Jens Wetzl2, and Andreas Maier1 | ||
1Pattern Recognition Lab, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 2Magnetic Resonance, Siemens Healthcare GmbH, Erlangen, Germany, 3Siemens Medical Solutions USA, Inc, Princeton, NJ, United States, 4Department of Radiology, University Medical Center, Johannes Gutenberg-University Mainz, Mainz, Germany, 5Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, Germany, 6Diagnostikum Berlin, Berlin, Germany, 7Department of Cardiology, Robert Bosch Medical Center, Stuttgart, Germany, 8Siemens Healthcare France, Saint-Denis, France, 9Institut Cardiovasculaire Paris Sud, Cardiovascular Magnetic Resonance Laboratory, Hôpital Privé Jacques Cartier - Ramsay Santé, Massy, France, 10Division of Cardiology, Johns Hopkins University, Baltimore, MD, United States |
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In cardiac MRI, the Late Gadolinium Enhancement technique is usually performed after inversion recovery scout sequences that are acquired to null the myocardial properly for optimal image contrast. In clinical practice, the selection and adjustment of the inversion time for healthy myocardium nulling are manually performed. To standardize and automate the process, we propose an automated deep-learning-based system combined with a linear regression model, which automates the selection of the inversion time, taking into consideration the time delay between the inversion time scout and LGE sequences. In this work, we validated the system in a large retrospective study (N=765). |
| 4786 | Booth 4
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Multi-center evaluation of the novel Beat Sensor Cardiac triggering technology |
| Carmel Hayes1, Yan Tu Huang2, Manuela Rick1, Randall Kroeker1, Mario Bacher1, Yue Pan3, Juliet Varghese3, Orlando Simonetti3, Ning Jin4, Rachel Davids4, Kelvin Chow4, Rudy Vanliedekerke 5, Marieke Vangelder5, Johan Dehem5, Peter Gatehouse6, Raj Kumar Soundarajan 6, Ricardo Wage6, Alessia Azzu6, Sonia Nielles-Vallespin6, and Peter Speier1 | ||
1Siemens Healthcare GmbH, Erlangen, Germany, 2Siemens Shenzhen Magnetic Resonance, Shenzhen, China, 3The Ohio State University, Columbus, OH, United States, 4Siemens Medical Solutions USA, Malvern, PA, United States, 5Jan Yperman Ziekenhuis, Ieper, Belgium, 6Royal Brompton Hospital, London, United Kingdom |
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A multi-center evaluation of a Pilot Tone-based triggering technique using the BioMatrix Beat Sensor has been performed in healthy volunteers and patients undergoing a cardiac MRI examination. At five different sites, and two different field strengths, a wide range of MR sequences typically used in standard cardiac MRI examinations were successfully triggered using the prototype Beat Sensor Cardiac triggering technology. By including a short signal training and RF calibration step at the start of the examination, the device proved robust across a range of subjects, thereby offering an alternative means to trigger cardiac examinations without the need to attach electrodes. |
| 4787 | Booth 5
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Simultaneous learning of group-wise registration and joint segmentation of cardiac cine MRI with sparse annotation |
| Junwei Yang1,2, Pengfang Qian2, Thomas Kuestner3, Pietro Lio1, Dinggang Shen2,4, and Haikun Qi2 | ||
1Department of Computer Science and Technology, University of Cambridge, Cambridge, United Kingdom, 2School of Biomedical Engineering, ShanghaiTech University, Shanghai, China, 3Department of Interventional and Diagnostic Radiology, University Hospital of Tuebingen, Tuebingen, Germany, 4Shanghai United Imaging Intelligence Co., Ltd., Shanghai, China |
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Numerous deep learning methods have been proposed for cardiac cine MRI segmentation, while most of them require laborious annotation for supervised training. Herein, we propose an approach to perform group-wise registration and joint segmentation of cardiac cine images, by training a registration network in a self-supervised manner to align dynamic images to their mean image space and also a segmentation network in a weakly-supervised manner using sparsely-annotated data and predicted motions from the registration network. By training these two (registration and segmentation) networks simultaneously, our proposed joint learning approach provides better segmentations than the direct segmentation network. |
| 4788 | Booth 6
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Identification of Hemodynamic Biomarkers for Bicuspid Aortic Valve induced Aortic Dilation using Machine Learning |
| Pamela Franco1,2,3, Julio Sotelo1,3,4, Andrea Guala5, Lydia Dux-Santoy5, Arturo Evangelista5, José Rodríguez-Palomares5, Domingo Mery6, Rodrigo Salas4, and Sergio Uribe1,3,7 | ||
1Biomedical Imaging Center, School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 2Electrical Engineering Department, School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 3Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago, Chile, 4School of Biomedical Engineering, Universidad de Valparaíso, Valparaíso, Chile, 5Department of Cardiology, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain, 6Deparment of Computer Science, Pontificia Universidad Católica de Chile, Santiago, Chile, 7Radiology Department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile |
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Several studies have demonstrated the existence of altered hemodynamics in bicuspid aortic valve (BAV) patients. The objective of this study was to identify which hemodynamic parameters allow an accurate classification between BAV patients with dilated and non-dilated ascending aorta using machine learning (ML) algorithms. |
| 4789 | Booth 7
|
Quantification of in-vivo myocardial stiffness in the rat heart using transient mechanical waves |
| Marco Barbero Mota1, Giacomo Annio1, Guillaume Rucher2, Anna Wittgestein3, David Nordsletten3,4, Jordi Martorell5, and Ralph Sinkus1,3 | ||
1LVTS U1148, LVTS U1148 INSERM - Université de Paris, Paris, France, 2FRIM, INSERM - Université de Paris, Paris, France, 3School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 4Biomedical Engineering and Cardiac Surgery, University of Michigan, Ann Arbour, MI, United States, 5Chemical Engineering, IQS, Barcelona, Spain |
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Heart biomechanics play a crucial role in the diagnosis and prognosis of cardiac diseases. However, current gold standard methods are highly invasive and preclude continuous monitoring of patients’ myocardium stiffness as a biomarker. In this study, we report the first results of a novel magnetic resonance elastography technique that provides with high temporal and spatial resolution enabling accurate transient shear wave speed values quantification, as thereof travel through heart tissue. Although biased due to the thin-plate geometry of the heart, early and mid-late systole, and early diastole preliminary results intuitively match the expected dynamical biomechanics of the human heart. |
| 4790 | Booth 8
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Pulmonary proton density mapping and cardiac 31P MRS suggest an energetic basis for exercise-induced pulmonary congestion in HFpEF |
| Jack J. Miller1,2,3, Matthew K Burrage2, Moritz Hundertmark2, Ladislav Valkovič2,4, William D Watson2, Jennifer Rayner2, Nikant Sabharwal5, Vanessa M Ferreira2, Stefan Neubauer2,5, Oliver J Rider2,5, and Andrew J Lewis2,5 | ||
1Aarhus University, Aarhus, Denmark, 2OCMR (Oxford Center for Clinical Magnetic Resonance Research), University of Oxford, Oxford, United Kingdom, 3Department of Physics, University of Oxford, Oxford, United Kingdom, 4Department of Imaging Methods, Slovak Academy of Sciences, Bratislava, Slovakia, 5Department of Cardiology, Oxford University Hospitals NHS Trust, Oxford, United Kingdom |
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We show in 43 patients with 31P MRS, 1H CMR and a novel proton-density mapping sequence that a gradient of myocardial energetic impairment exists across a spectrum of HFpEF phenotypes of increasing clinical severity and worsening diastolic function. A greater degree of myocardial energetic deficit is linked to impaired LV systolic and diastolic functional reserve, to altered RV reserve and RV-PA coupling, and to exercise-induced pulmonary congestion assessed using novel proton density magnetic resonance imaging. A subgroup of HFpEF patients demonstrate transient pulmonary congestion during exercise which can be non-invasively assessed using exercise CMR and proton density mapping. |
| 4791 | Booth 9
|
Data driven whole-brain cardiac signal regression from highly accelerated fMRI acquisitions |
| Marco Marino1,2, Nigel Colenbier1,2,3, Nicola Filippini2, Giovanni Pellegrino2, Daniele Marinazzo2,3, and Giulio Ferrazzi2 | ||
1Research Center for Motor Control and Neuroplasticity, KU Leuven, Leuven, Belgium, 2IRCCS San Camillo Hospital, Venice, Italy, 3Department of Data Analysis, Faculty of Psychology and Educational Sciences, Ghent University, Ghent, Belgium |
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Cardiac pulsation is a physiological confound of fMRI analysis pipelines and so accurate mapping of cardiac contributions to the BOLD signal is highly warranted. To overcome cardiac aliasing associated with the limited temporal resolution in fMRI, we developed a data-driven methodology to spatially and temporally resolve cardiac contributions from the BOLD signal itself (i.e without the need of processing external physiological recordings such as PPU/ECG signals). This is achieved by combining simultaneous multi-slice imaging and a dedicated hyper-sampling decomposition scheme. The proposed methodology is fully data driven and it does not make specific assumptions on the shape of cardiac pulsation. |
| 4792 | Booth 10
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AVA Diagnostics - multimodality computer assisted aneurysm management tool |
| Žiga Bizjak1, Aichi Chien, PhD, FAHA2, Erazem Kos1, and Žiga Špiclin1 | ||
1Laboratory of Imaging Technologies, Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia, 2Division of Interventional Neuroradiology, Department of Radiological Sciences, Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States |
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Management of (un)ruptured intracranial aneurysms (IAs) through early detection and continuous rupture risk assessment is becoming an integral part of IA treatment. This study showcases the capabilities of AVA Diagnostics tool and its IA workflow including automatic vessel segmentation, detection and isolation, morphologic quantification, future growth prediction and follow-up morphologic analysis. Each of the tools was successfully validated on multimodal MRA, CTA and 3D-DSA scans. The AVA Diagnostics thus aims to simplify the management of IAs through extensive use of computer-assisted image analysis and analytics tools, and enable their application in large-scale studies and in regular clinical workflow. |
| 4793 | Booth 11
|
Brain microstructural changes in stroke patients at subacute/chronic stages by mean of advanced diffusion MRI: a longitudinal study |
| Shi-Ming Wang1, Guglielmo Genovese2,3,4, Belen Diaz3,5, Fan Huang6, Stéphane Lehericy2,3, Hui Zhang1, Charlotte Rosso3,5, Francesca Branzoli2,3, and Marco Palombo1,7,8 | ||
1Centre for Medical Image Computing (CMIC), Department of Computer Science, University College London, London, United Kingdom, 2Paris Brain Institute - ICM, Centre de NeuroImagerie de Recherche - CENIR, Paris, France, 3Sorbonne Université, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, F-75013, Paris, France, 4Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 5Department of Neurology, Pitié-Salpétrière Hospital, Paris, France, 6Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 7Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 8School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom |
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This study characterises microstructural changes in stroke lesions using NODDI and WMTI, two advanced diffusion MRI techniques, and compares their ability to detect WM alterations on the ipsi-lesional and contralesional sides of 12 patients scanned 2 weeks, 1 month and 3 months after onset. Region-of-interest analysis showed that ODI and FWF from NODDI were significantly altered at the lesion. Significant changes were also found in the WMTI parameters of several ipsi-lesional white matter tracts. Our prospective analysis suggests that the application of enhanced dMRI methods such as NODDI and WMTI can help to further comprehend the biophysical mechanism behind ischemia. |
| 4794 | Booth 12
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A pilot study on the application of explainable deep learning to ADC maps for predicting functional outcome of ischemic stroke patients |
| Esra Zihni1, Bryony L. McGarry1,2, Jen Guo3, Rani Gupta Sah3, George Tadros3, Philip A. Barber3, and John D. Kelleher1,4 | ||
1PRECISE4Q Predictive Modelling in Stroke, Technological University Dublin, Dublin, Ireland, 2School of Psychological Science, University of Bristol, Bristol, United Kingdom, 3Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada, 4ADAPT Research Centre, ICE Research Institute, Technological University Dublin, Dublin, Ireland |
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Applying deep learning models to MRI scans of acute stroke patients to extract features indicative of functional outcome could assist a clinician’s treatment decisions. Here, we trained convolutional neural network models on ADC maps from hyper-acute ischemic stroke patients to predict 3-month mRS and used an interpretability technique to highlight regions in the ADC maps that were most important in the prediction of good and poor outcomes. Although the models had poor predictive power, the visual explanations supported our previous findings that predictions might be based not on ischemic regions, but on other relevant information inherent in the image. |
| 4795 | Booth 13
|
Deep learning Circle of Willis arterial labeling strategies for pipeline of cerebrovascular disease analysis |
| Žiga Bizjak1, Aichi Chien, PhD, FAHA2, Jan Tasič1, and Žiga Špiclin1 | ||
1Laboratory of Imaging Technologies, Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia, 2Division of Interventional Neuroradiology, Department of Radiological Sciences, Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States |
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The correlation between different variants of the Circle of Willis (CoW) and cerebrovascular disorders such as stroke, aneurysms and mental disorders is not yet well understood. A step towards a better understanding of the role of CoW in the aforementioned diseases is the automatic labeling of main vessels. In this work we tested three different approaches and observed high mIoU value of 0.870. As such the automatic anatomical labelling of the CoW seems feasible for clinical evaluation of the association of different anatomical variants with the risk factors of cerebrovascular pathologies. |
| 4859 | Booth 1
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AI-based Fully Automated 4D Flow Image Reconstruction and Post-Processing Pipeline in under 10 minutes. |
| Haben Berhane1, Michael Scott1, Ashitha Pathrose1, Patrick McCarthy2, Chris Malaisrie2, Bradley Allen3, Ryan Avery3, and Michael Markl1 | ||
1Biomedical Engineering, Northwestern University, Chicago, IL, United States, 2Cardiac Surgery, Northwestern University, Chicago, IL, United States, 3Radiology, Northwestern University, Evanston, IL, United States |
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4D flow MRI provides comprehensive assessment of cardiovascular hemodynamics. However, the current clinical usage of standard 4D flow MRI is hindered by long scan times and extensive, time-consuming post-processing such as eddy current corrections, noise masking, and 3D vessel segmentation. We seek to address this by developing a fully automated image reconstruction and post-processing pipeline for highly-accelerated aortic 4D flow MRI (R=5.7-10.2). The fully automated pipeline was shown to provide good-to-excellent agreement in quantitative and hemodynamic measures to conventional 4D flow MRI (GRAPPA, R=2) with manual post-processing. Additionally, the pipeline only requires <10 minutes compared to 20 minutes manually. |
| 4860 | Booth 2
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Velocity to Pressure Mapping in Stenotic Pulsatile Flows with an Encode-Decoder Deep Network |
| Ruponti Nath1, Amirkhosro Kazemi1, Marcus Stoddard2, and Amir Amini1 | ||
1ECE, University of Louisville, Louisville, KY, United States, 2Cardiovascular Division, Robley Rex VA Medical Centre, Louisville, KY, United States |
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We propose a novel deep learning based approach to estimate pressure drop inside a stenotic valve from 4D Flow MRI velocities. A neural network architecture learns the relationship of three directional velocities and predicts pressure as output. The network was tested on real 4D flow MRI data of aortic valvular flow both in-vitro and in vivo. Estimated in-vitro pressure drop by proposed method shows (3-5)% relative pressure drop error with corresponding CFD pressure. Estimated In-vivo pressure drop was also compared with doppler Echocardiography and simplified and modified Bernoulli at peak systole timepoints in 10 patients with aortic stenosis. |
| 4861 | Booth 3
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Highly accelerated 4D flow MRI using compressed sensing in type B aortic dissection |
| Ozden Kilinc1, Stanley Chu1, Elizabeth K. Weiss1,2, Justin Baraboo1,2, Anthony Maroun1, Ning Jin3, Kelvin Chow1,4, Xiaoming Bi4, Rachel Davids4, Chris Mehta5, S. Chris Malaisrie5, Andrew Hoel6, Michael Markl1,2, and Bradley D. Allen1 | ||
1Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 2Department of Biomedical Engineering, Northwestern University, Chicago, IL, United States, 3Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc., Cleveland, OH, United States, 4Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc., Chicago, IL, United States, 5Division of Cardiac Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 6Division of Vascular Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States |
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4D flow MRI is an established quantitative MR imaging technique for evaluating complex blood flow patterns. However, clinical applications of standard 4D flow MRI technique is limited by long scan times associated with multidimensional imaging. Compressed sensing (CS) acceleration can significantly reduce scan time through dramatic data undersampling, but it is not clear how this undersampling impacts assessment of flow patterns in type B aortic dissection (TBAD). In this study, we investigate performance of highly accelerated CS 4D flow MRI at two different acceleration factor levels (R=7.7 and 10.2) to evaluate aortic flow dynamics in volunteers and patients with TBAD. |
| 4862 | Booth 4
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Assessment of arterial pulsatility of cerebral perforating arteries using 7T high-resolution dual-VENC phase-contrast MRI |
| Jianing Tang1, Samantha J Ma2, and Lirong Yan1,3 | ||
1USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Siemens Medical Solutions USA, Inc., Los Angeles, CA, United States, 3Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States |
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A dual VENC strategy was applied in 2D high-resolution phase-contrast MRI to improve the sensitivity of arterial pulsatility measurement in cerebral perforating arteries at 7T. Compared to a single VENC of 40cm/s, significant increase in the number of detected perforators was observed using a dual-VENC approach with VENC of 20cm/s and 40cm/s. Reproducibility of arterial pulsatility measurement in perforating arteries was evaluated in test-retest experiments. Good agreement was achieved between test-retest pulsatility measurements. |
| 4863 | Booth 5
|
Dynamic Contrast Enhanced (DCE) MRI of the Abdominal Aortic Aneurysm (AAA) Wall |
| Ang Zhou1, Huiming Dong1, Joseph Leach1, Chengcheng Zhu2, David Saloner1, Michael Hope1, and Dimitrios Mitsouras1 | ||
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Department of Radiology, University of Washington, Seattle, WA, United States |
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Abdominal Aortic Aneurysms (AAAs) are common in older men. Guidelines recommend repair at an aneurysm diameter greater than 5.5 cm, but some smaller aneurysms experience catastrophic rupture. Aneurysm features beyond diameter have been explored as markers of disease progression. We used DCE MRI to explore the inhomogeneity of contrast kinetics, including Ktrans, in the aneurysm wall and assess if these markers independently predict AAA progression. Significant differences in DCE metrics were identified around the AAA circumference. Area under enhancement-time curve and enhancement slope correlated with growth rate but not diameter, suggesting that DCE may provide diameter-independent information regarding AAA risk. |
| 4864 | Booth 6
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AI-based Image Reconstruction of kt-accelerated Intracranial Dual-Venc 4D Flow MRI |
| Haben Berhane1, Jackson E Moore1, Ann Ragin1, Eric Russell2, Fan Caprio3, Susanne Schnell4, Sameer A Ansari2, and Michael Markl1 | ||
1Biomedical Engineering, Northwestern University, Chicago, IL, United States, 2Radiology, Northwestern University, Chicago, IL, United States, 3Neurology, Northwestern University, Chicago, IL, United States, 4Radiology, University of Greifswald, Greifswald, Germany |
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4D flow MRI provides a comprehensive assessment of hemodynamics through the 3D visualization and quantification of blood flow. However, its current clinical usage is hindered by long scan times. Recent developments have shown deep learning to be highly effective in accelerating image reconstruction, but no study has shown the its effectiveness in reconstructing highly undersampled cerebrovascular 4D flow MRI data. As such, we developed a CNN for the reconstruction of kt-accelerated intracranial dual-venc 4D flow MRI (R=5). We found that the CNN showed excellent SSIM values (0.94[0.93-0.95]) and moderate-to-good net flow and peak velocity agreement with the conventionally reconstructed data. |
| 4865 | Booth 7
|
Vortex ring reveals a novel non-invasive hemodynamic biomarker associated with the location of maximum pressure drop in arterial stenosis |
| Amirkhosro Kazemi1,2, Sean Callahan1,2, Ruponti Nath1,2, Marcus Stoddard2,3, and Amir A. Amini1,2 | ||
1Electrical and Computer Engineering, University of Louisville, Louisville, KY, United States, 2Robley Rex VA Medical Center, Louisville, KY, United States, 3Cardiovascular Division, University of Louisville, Louisville, KY, United States |
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We propose vortex ring as a new indicator of the location of maximum pressure drop along a phantom model of arterial stenosis. We investigated details of the flow structure of post stenotic jet with presence of the vortex ring in stenotic phantoms with 87% reduction in area using CFD velocities and 4D flow MRI. The pressure, velocity, and vorticity fields were quantitatively analyzed with the presence of the vortex ring in the spatiotemporal domains. It was found that the location of the vortex ring is associated with the location of the maximum pressure drop, axial velocity, and vorticity magnitude. |
| 4866 | Booth 8
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Validation of Qp/Qs quantification based on 4D flow MRI: effects of scan acceleration techniques |
| Takashi Fujiwara1, Erin K Englund1, Mehdi H Moghari1, Brian Fonseca2, Lorna P Browne1, and Alex J Barker1,3 | ||
1Department of Radiology, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 2Department of Pediatrics, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 3Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, United States |
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The ratio of pulmonary to systemic blood flow (Qp/Qs) is a clinically important index to estimate the existence and amount of cardiovascular shunt flow and to determine the need for surgical intervention for congenital heart disease patients. Accelerated 4D flow MRI is capable of measuring Qp/Qs in a single acquisition, but its accuracy and reliability are not well established. We compared conventional 2D phase-contrast MRI and two 4D flow MRI acquisitions with different acceleration techniques to investigate accuracy of Qp/Qs quantification with accelerated 4D flow in adult healthy volunteers (N=10). Consequently, we found no statistical differences in Qp/Qs. |
| 4867 | Booth 9
|
Distributed memory-efficient deep learning reconstruction for improved SIMBA whole-heart coronary MRI |
| Chi Zhang1,2, Ludovica Romanin3,4, Davide Piccini3,4, Steen Moeller2, Matthias Stuber3,5, and Mehmet Akçakaya1,2 | ||
1Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 3Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 4Advanced Clinical Imaging Technology, Siemens Healthcare AG, Bern, Switzerland, 5Center for Biomedical Imaging, Lausanne, Switzerland |
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SImilarity-driven Multi-dimensional Binning Algorithm (SIMBA) is a recently proposed technique for identifying motion-consistent clusters in free-running whole-heart MRA acquisitions, where the clusters are subsequently reconstructed using conventional approaches. Physics-guided deep learning (PG-DL) reconstruction has gained popularity with its superior performance at higher acceleration rates and may further improve the image quality of free-running whole-heart MRA in conjunction with SIMBA. However, PG-DL is difficult to apply to 3D non-Cartesian acquisitions due to hardware limitations. In this work we enable distributed memory-efficient PG-DL for large-scale SIMBA datasets, showing preliminary results in which PG-DL improves image quality compared to conventional methods. |
| 4868 | Booth 10
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Comparison of 4D, 2D, and 1D phase-contrast MRI quantification of aortic pulse wave velocity in healthy adults |
| Erin K Englund1, Takashi Fujiwara1, Kelly B Jarvis2, Michael Markl2, Daniel Enge3, Jane E.B. Reusch4, and Alex J Barker1 | ||
1Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 2Radiology, Northwestern University, Chicago, IL, United States, 3Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 4Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States |
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Pulse wave velocity (PWV) is an important measure of cardiovascular health, related to vascular stiffness. Aortic PWV can be evaluated with a variety of MRI methods, however a direct comparison of PWV results quantified from 4D flow, 2D phase contrast (PC), and 1D projection PC MRI has not been performed. Here, PWV derived from 4D, 2D, and 1D-PC MRI acquisitions and associated analysis strategies were compared in the aortic arch. Relative agreement was observed among methods. 2D-PC PWV derived from the flow-area approach had substantial variability, likely due to the limited spatial/temporal resolution, and user-dependence of analysis. |
| 4869 | Booth 11
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Can blood flow and artery patency alterations in medium-to-large arteries predict alteration in cognitive function? |
| Kaiyu Zhang1, Zhensen Chen2, Li Chen1, Gador Canton1, Duygu Baylam Geleri1, Kristi Pimentel1, Niranjan Balu1, Thomas Hatsukami1, and Chun Yuan1 | ||
1Vascular Imaging Lab and BioMolecular Imaging Center, Department of Radiology, University of Washington, Seattle, WA, United States, 2Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China |
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Association between brain tissue level perfusion and cognitive decline has been previously documented. However, contribution of blood flow and artery patency in medium-to-large arteries and its relation to tissue level perfusion and cognition remain unclear. In this study, 3D-TOF, ASL, and SNAP, an MRA technique sensitive to slow blood flow, were acquired at baseline and 12-months follow-up. A vascular map construction software was used to measure changes in medium-to-large arterial features. Changes in SNAP artery length and branch number during follow-up were significantly associated with changes in cognitive function, while no such association was found with ASL tissue level perfusion. |
| 4870 | Booth 12
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Accelerating 5D Whole-Heart MRA Reconstruction Using a Limited Number of Cardiac and Respiratory Frames |
| Yitong Yang1, Jackson Hair1, Jerome Yerly2, Davide Piccini3, Matthias Stuber4, and John Oshinski1,5 | ||
1Biomedical Engineering, Emory University/Georgia Institute of Technology, Atlanta, GA, United States, 2Diagnostic and Interventional Radiology, Lausanne University Hospital, Lausanne, Switzerland, 3Siemens Healthcare, Lausanne, Switzerland, 4Lausanne University Hospital, Lausanne, Switzerland, 5Radiology, Emory University School of Medicine, Atlanta, GA, United States |
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Under-sampled reconstruction of retrospectively gated 5D free-running acquisition is time-consuming and computationally intensive. In this work, a limited reconstruction method is proposed which provides an efficient way to compute a static cardiac volume from free-breathing, ECG-free 5D free-running CMR acquisitions. Structural similarity index measure is used to compare the limited reconstructions with the fully reconstructed image at the physiologic state of interest. The proposed limited reconstruction method achieves a SSIM of 0.9 using only 22% of the full reconstruction time and an SSIM of 0.95 using 44% of the full reconstruction. |
| 4871 | Booth 13
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Motion-Corrected Multiphase Imaging with Steady-state Free Precession for Free-breathing 3D Coronary Angiography |
| Kwang Eun Jang1,2, Dwight G. Nishimura2, and Shreyas S. Vasanawala3 | ||
1Department of Bioengineering, Stanford University, Stanford, CA, United States, 2Magnetic Resonance Systems Research Lab (MRSRL), Department of Electrical Engineering, Stanford University, Stanford, CA, United States, 3Department of Radiology, Stanford University, Stanford, CA, United States |
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For free-breathing 3D coronary angiography, we consider a new multiphase acquisition that consists of a series of short imaging blocks to reduce motion blur in the acquisition window. However, this approach poses two challenges: (1) because the alterations of readout gradient waveforms become large due to the shortened imaging window, eddy current artifacts appear in steady-state free precession imaging, and (2) motion among cardiac phases needs to be addressed. In this work, we propose a new ordering scheme to establish smooth transitions between conic interleaves. Phase-to-phase motion is estimated using self image-based navigators and corrected by motion-based reconstruction. |
| 4872 | Booth 14
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Highly Accelerated Free-Breathing Real-Time 2D Flow Imaging using Compressed Sensing and Shared Velocity Encoding |
| Fei Xiong1, Ning Jin2, Anna Lena Emrich 3, SarahRose Hall3, Jeanie Marie Ruddy3, Jonathan Aldinger4, Gabrielle Young 4, U Joseph Schoepf4, Daniel Giese5, Tilman Emrich 4, and Akos Varga-Szemes4 | ||
1Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc, Charleston, SC, United States, 2Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc, Chicago, IL, United States, 3Department of Surgery, Medical University of South Carolina, Charleston, SC, United States, 4Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States, 5MR Cardiovascular Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany |
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We aim to demonstrate the feasibility of a highly accelerated, free-breathing RT PC technique empowered by compressed sensing (CS) and shared velocity encoding (SVE) which allows a scan time less than 5s and fast inline image reconstruction. |
| 4873 | Booth 15
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Follow-up versus baseline 4D flow-derived in vivo hemodynamic parameters stratify descending aorta dissection patients with enlarging aortas |
| Stanley Chu1, Ozden Kilinc 2, Elizabeth Weiss2, Kelly Jarvis2, Christopher Mehta 2, Chris Malaisrie 2, Andrew Hoel2, Maurice Pradella 2, Bradley Allen2, and Michael Markl2,3,4 | ||
1Radiology, Northwestern University, Chicago, IL, United States, 2Northwestern University, Chicago, IL, United States, 3Siemens Healtineers, Erlangen, Germany, 4Cryolife Inc., Kennesaw, GA, United States |
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Increasing aorta diameter in type B aortic dissection (TBAD) patients is associated with adverse clinical outcomes. Our study evaluates true and false lumen (TL, FL) hemodynamics (kinetic energy (KE), maximum velocity (MV), forward flow (FF), and reverse flow (RF) in baseline and follow-up thoracic aorta 4D flow (4DF) MRI. Baseline aortic diameter does not correlate with aortic growth rate, while FL-total KE, FF, and RF correlate negatively. At follow-up, larger increases in FL-total KE, total FF, KE ratio and FL-mean MV correlate positively with aortic growth rate. Investigating hemodynamic changes in follow-up 4DF may be useful for evaluating TBAD patients. |
| 4874 | Booth 1
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Potential regulation of cerebral blood flow by the basal forebrain |
| Zongpai Zhang1, Elizabeth Riley2, Adam K. Anderson2, Eve D. DeRosa2, and Weiying Dai1 | ||
1Computer Science, State University of New York at Binghamton, Binghamton, NY, United States, 2Department of Psychology, Cornell University, Ithaca, NY, United States |
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The basal forebrain (BF) has a known regulatory role in the cholinergic vasodilatory system, increasing cerebral blood flow (CBF) in the cerebral cortex using animal studies. However, parallel human studies have never been performed. Thirty-three young adults and 27 older adults were tested for the aged-related changes in arterial transit time (ATT) and CBF, which were measured using arterial spin labeling (ASL). We observed the age-related CBF and ATT changes in the basal forebrain and other brain regions, which provide a foundation for investigating the regulatory role of the basal forebrain on the cholinergic vasodilatory system. |
| 4875 | Booth 2
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Reliability of Periventricular White Matter Cerebral Blood Flow using Different ASL protocols |
| Shokufeh Sadaghiani1, William Tackett1, M. Dylan Tisdall2, John A. Detre1, and Sudipto Dolui2 | ||
1Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States |
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Cerebral blood flow (CBF) in periventricular white matter (PVWM) may provide a mechanistically specific biomarker of cerebral small vessel disease. We compared the reliability of PVWM CBF obtained from arterial spin labeling MRI acquired twice separated by a week, using different protocols involving standard, long labeling duration, single and multiple inflow saturation (MIS), and level of background suppression (BS), in young healthy participants. The MIS protocol with 99% BS significantly improved the temporal signal to noise ratio of the acquisition, with a subtle improvement of intersession-reliability. Reliability of PVWM CBF was of the same order as other conventional regions of interest. |
| 4876 | Booth 3
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Highly Accelerated Myocardial Perfusion Using Physics-guided Deep Learning With Structure-encoded Coil Maps |
| Omer Burak Demirel1,2, Burhaneddin Yaman1,2, Steen Moeller2, Sebastian Weingärtner3, and Mehmet Akçakaya1,2 | ||
1Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 3Department of Imaging Physics, Delft University of Technology, Delft, Netherlands |
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Myocardial perfusion cardiac MRI is widely used to functionally assess coronary artery disease. Although numerous acceleration techniques are used, improved spatio-temporal resolutions and coverage are desirable. Deep learning (DL) reconstruction has shown improvement over conventional reconstruction techniques at higher accelerations. Yet, SNR/contrast changes across perfusion dynamics hinder their generalization performance. In this work, we propose a multi-coil encoding operator that uses coil maps encoding structural information for physics-guided DL. This provides a uniform contrast at the network output across dynamics, leading to improved image quality compared to physics-guided DL with ESPIRiT coil maps, as well as conventional acceleration methods. |
| 4877 | Booth 4
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Mapping the Age Effect on Cortical Arterial Arrival Time and Perfusion using multi-delay pCASL |
| Yutong Sun1, Paul T.H Chang 1, and J. Jean Chen2 | ||
1Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada |
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Multi-delay arterial spin labeling (ASL) has made it possible to non-invasively quantify cerebral hemodynamic changes in aging, including cerebral blood flow (CBF) and arterial arrival time (ATT). However, limited numbers of studies exist to focus on the spatial heterogeneity of age effects on both CBF and ATT. In this study, we map the relationships between age, CBF and ATT on the cerebral cortex using multi-delay pseudo-continuous ASL (pCASL) data from the Human Connectome Project in Aging. |
| 4878 | Booth 5
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Volumetric Renal Perfusion Imaging with pCASL – Comparison of 3D TSE and 3D GraSE Readout |
| Limin Zhou1, Yiming Wang1, and Ananth Madhuranthakam1,2 | ||
1Radiology, University of Texas Southwestern Medical Center, DALLAS, TX, United States, 2Advanced Imaging Research Center, University of Texas Southwestern Medical Center, DALLAS, TX, United States |
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Recent consensus recommended SE-EPI as the preferred readout for 2D single-slice renal perfusion imaging using pCASL. Compared to single-slice 2D acquisition, 3D acquisitions can achieve higher SNR, larger slice coverage, and optimal background suppression in similar scan times. In this study, we compared 3D GRASE, the recommended 3D readout for brain perfusion imaging, with an optimized 3D TSE readout using Cartesian acquisition with spiral profile reordering and Variable Density Sampling (VD-CASPR) in 4 healthy volunteers for volumetric renal perfusion imaging. Results showed that 3D pCASL with TSE VD-CASPR is more robust and has higher SNR than 3D pCASL with GRASE. |
| 4879 | Booth 6
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Improving Spatial Resolution of Brain and Renal ASL MR Images using 3D Cartesian TSE and Compressed SENSE Reconstruction |
| Yiming Wang1, Limin Zhou1, Marco C. Pinho1,2, Ivan Pedrosa1,2,3, Joseph A. Maldjian1,2, and Ananth J. Madhuranthakam1,2 | ||
1Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3Department of Urology, UT Southwestern Medical Center, Dallas, TX, United States |
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Arterial spin labeled (ASL) MRI is often acquired at reduced spatial resolution due to lower signal to noise (SNR), although higher spatial resolution within clinically feasible scan times is desired. In this study, we applied Compressed Sensing–Sensitivity Encoding (CS-SENSE) to 3D Cartesian TSE with Variable Density (VD) sampling to achieve higher spatial resolution ASL-MRI without prolonging acquisition time. Perfusion images acquired with CS-SENSE showed good SNR and image quality in both brains and kidneys, without introducing bias to perfusion quantification. This may be particularly useful to measure perfusion changes in small-sized lesions in both brains and kidneys. |
| 4880 | Booth 7
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Quantitative myocardial perfusion using whole-heart, 2D SMS and 3D sequences alternating every heartbeat |
| Qi Huang1,2, Jason Mendes1, Ganesh Adluru1, and Edward DiBella1 | ||
1Utah Center for Advanced Imaging Research (UCAIR), University of Utah, Salt Lake City, UT, United States, 2Biomedical Engineering, University of Utah, Salt Lake City, UT, United States |
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A sequence with 2D simultaneous multi-slice (SMS) and 3D stack-of-stars (SoS) alternating each heartbeat sequence has been proposed previously1. Here, we increase the heart-coverage of the 2D SMS portion of the scan from 3 slices to 6 slices, to match the coverage of the 3D SoS method. Three minipigs and one healthy volunteer were studied using this method at both adenosine stress and rest cases, and the sequences gave flows with reasonable agreement. |
| 4881 | Booth 8
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Customized whole-brain covering GRASE in multi-delay pCASL for distinct contrasts and adequate SNRs in hemodynamic parameter mappings |
| Yichen Hu1, Qing Wei2, Zhongyang Zhou2, Junpu Hu2, Jun Xie2, and Jian Xu1 | ||
1UIH America, Inc., Houston, TX, United States, 2United Imaging Healthcare, Shanghai, China |
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We report that manipulation of GRASE readout with SORT view-ordering in multi-delay ASL on either gradient echo trains for adjusted spatial resolutions or FSE train for modulated T2-blurring can significantly alter the perfusion hemodynamic parameter mapping contrasts among tissues and among cerebral lobes under different pathways of blood circulation, and can meanwhile regulate the SNRs of the maps. Among the performed GRASE designs, the readout with moderate spatial resolution and segmented kz is recommended for sharp GM/WM contrasts in CBF and ATT maps in conjunction with distinct contrast between anterior and posterior circulations in the ATT map, with adequate SNRs. |
| 4882 | Booth 9
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Sinusoidal oxygen respiratory paradigm for perfusion MRI |
| Chau Vu1, Jian Shen1, Soyoung Choi2, Koen Baas3, and John Wood4 | ||
1Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, 2Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, United States, 3Amsterdam UMC, Amsterdam, Netherlands, 4University of Southern California, Los Angeles, CA, United States |
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Gadolinium-based Dynamic Susceptibility Contrast (DSC) MRI is a popular technique to measure brain perfusion. However, it requires the use of an invasive exogenous contrast agent which accumulates in tissue and impedes repeated measurements. To overcome the need of gadolinium injection, this study employed the noninvasive deoxygenated DSC (dDSC) technique and proposed a novel respiratory challenge paradigm which delivers a sinusoidally-modulated oxygen stimulus as an endogenous contrast to measure perfusion. We evaluated this paradigm on 10 healthy controls and compared cerebral blood flow against other perfusion MRI techniques such as gadolinium-based DSC and arterial spin labeling. |
| 4883 | Booth 10
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Multi-delay pCASL with optimal post-labeling delay times by incorporating ATT probability distribution improves accuracy of CBF measurement |
| Yining He1, Zhiyuan Zhang1, Xingfeng Shao1, Timothy Macaulay2, and Lirong Yan1 | ||
1USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Division of Biokinesiology and Physical Therapy, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, United States |
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The accuracy of CBF measurement in multi-delay ASL relies on the design of optimal PLDs. In this study, we optimized PLDs in 3D pCASL using a previously proposed optimization framework based on the Cramer-Rao lower bound optimization by incorporating different ATT prior distributions including in-vivo Gaussian distribution and uniform distribution. Evenly spaced PLDs were also applied for comparison. Both simulation and in vivo data suggest that optimal PLDs using in vivo ATT Gaussian distribution offer the best performance in terms of the accuracy of CBF estimation. |
| 4884 | Booth 11
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Myocardial first-pass perfusion assessed by cardiac magnetic resonance and neutrophil to lymphocyte ratio in patients with cardiac syndrome X |
| Gang zhang1, Wei Xing1, Tingting Li2, Yan Zheng1, Ying Huang3, Junjing He1, and Xiuzheng Yue4 | ||
1Department of Magnetic Resonance, The First Affiliated Hospital of Henan University of CM, Zhengzhou, China, 2Department of Magnetic Resonance, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China, 3The First Affiliated Hospital of Henan University of CM, Zhengzhou, China, 4Philips Healthcare, Zhengzhou, China |
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Cardiac syndrome X (CSX) is also known as microvascular angina pectoral, the pathogenesis of which has not been clearly determined [1]. A coronary angiography study [2] showed that neutrophil to lymphocyte ratio (NLR), as a marker of inflammatory response in a variety of cardiovascular diseases, was elevated in CSX patients. The NLR of CSX patients with impaired myocardial perfusion was higher than that of patients without it, such as unstable angina pectoris (UAP) patients. In this study, we found that the distribution of myocardial first-pass perfusion was heterogeneous in each segment of CSX patients in the resting stage, better than that of UAP patients. The correlation between perfusion parameters and NLR was high and significant. |
| 4885 | Booth 12
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Blood-brain barrier permeability in response to caffeine challenge |
| Zixuan Lin1, Dengrong Jiang1, Peiying Liu1,2, Abhay Moghekar3, and Hanzhang Lu1 | ||
1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States |
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Caffeine is known to alter brain physiology by acting as an adenosine antagonist, but its effect on the BBB permeability to water is not fully elucidated. In this study, we utilized water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST) MRI to investigate the change of BBB permeability after caffeine challenge in young healthy adults. Results showed that after caffeine ingestion, water extraction across BBB increased as global cerebral blood flow decreased, while the BBB permeability to water remained unchanged, indicating a relative stable BBB function in response to caffeine challenge, which can be important for normal brain function. |
| 4886 | Booth 13
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Augmented Perfusion Quantified by MRI Depends on Collateral Recruitment in Middle Cerebral Artery Occlusion: A Pilot Study |
| Mira Liu1, Niloufar Saadat1, Yong Jeong1, Steven Roth2, Marek Niekrasz1, Gregory Christoforidis1, and Timothy Carroll1 | ||
1University of Chicago, Chicago, IL, United States, 2University of Illinois, Chicago, IL, United States |
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We have developed an experimental model and quantitative MRI biomarkers to quantify the effects of therapeutic intervention to enhance collateralization in acute stroke. We performed controlled experiments in a pre-clinical canine model of ischemic stroke and use quantitative cerebral MR perfusion with DSC, intravoxel incoherent motion (IVIM), and neutron capture microsphere deposition, x-ray angiography for collateralization, and MR diffusion imaging for infarction to demonstrate a significant increase in perfusion and decrease in infarct growth in the hyperacute phase of an ischemic stroke. |
| 4887 | Booth 14
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MR measures of regional cerebral blood flow and cortical thickness are tightly linked to the proximity of large cerebral arteries |
| Samantha Cote1, Marco Perez Caceres1, Felix Dumais1, Jean-Francois Lepage1, and Kevin Whittingstall1 | ||
1Université de Sherbrooke, Sherbrooke, QC, Canada |
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Using time of flight magnetic resonance angiography, we explored how local variations in cerebral arterial morphology are related to cerebral blood flow (CBF) and cortical thickness (CT). We observed a significant, negative relationship between the proximity of a region of interest to an artery and CBF and CT such that regions proximal to large arteries have higher CBF and CT. These results highlight the importance of considering underlying cerebral vasculature when studying the human brain using MRI as it can lead to significant biases in commonly employed metrics. |
| 4888 | Booth 1
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Contrast-free MR Angiography and Venography for Visualization of Iliac Vein Compression Syndrome in less than 10 minutes |
| Vadim Malis1, Jirach Kungsamutr2, Won Bae1, Xiaowei Zhang1, Yoshimori Kassai3, Albert Hsiao1, John S Lane4, and Mitsue Miyazaki1 | ||
1Radiology, UC San Diego, San Diego, CA, United States, 2Bioengineering, UC San Diego, San Diego, CA, United States, 3Canon Medical Systems Corp., Tochigi, Japan, 4Surgery, UC San Diego, San Diego, CA, United States |
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Iliac vein compression syndrome, known as May-Thurner syndrome (MTS), is a condition when the right common iliac artery constrains the flow in the left common iliac vein. Currently, ultrasound and CT venography (CTV) are the imaging modalities of choice for the diagnosis. We propose a framework to visualize iliac vein and artery utilizing contrast free MR venography and MR angiography in less than 10 minutes. |
| 4889 | Booth 2
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Imaging Ascending Thoracic Aortic Aneurysm Wall Stretch: A Comparison to Biaxial Mechanical Testing |
| Huiming Dong1, Henrik Haraldsson1, Joseph Leach1, Ang Zhou1, Megan Ballweber1, Chengcheng Zhu2, Yue Xuan3, Zhongjie Wang3, Michael Hope1, Liang Ge3, Frederick H. Epstein4, David Saloner1, Elaine Tseng3, and Dimitrios Mitsouras1 | ||
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Department of Radiology, University of Washington, Seattle, WA, United States, 3Department of Surgery, University of California, San Francisco, San Francisco, CA, United States, 4Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States |
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Ascending thoracic aortic aneurysm (aTAA) can result in life-threatening rupture or dissection. Displacement encoding with stimulated echoes (DENSE) is a non-invasive phase-contrast MRI technique that can measure aTAA wall deformation during the cardiac cycle. This study investigated DENSE-derived aTAA wall stretch in patients and found that the ratio between aTAA stretch and descending aorta stretch was different in patients who met surgical repair criteria from those who did not. Moreover, mechanical properties of aTAA specimens from patients who underwent surgery correlated significantly with in vivo DENSE measurements. Our findings suggest DENSE as a potential imaging marker for understanding aTAA progression. |
| 4890 | Booth 3
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Predicting penumbral tissue death using intravoxel incoherent motion MRI in a canine large vessel occlusion model |
| Mohammed Salman Shazeeb1, Robert King1, Zeynep Vardar1, Josephine Kolstad1, Vania Anagnostakou1, Nils Henninger1, and Matthew Gounis1 | ||
1University of Massachusetts Medical School, Worcester, MA, United States |
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In acute ischemic stroke due to large vessel occlusion (LVO), information about the penumbral tissue can be vital in making decisions on how to treat ischemic stroke patients in the clinic. This study investigated the use of intravoxel incoherent motion (IVIM) MRI in a canine LVO model to quantify the perfusion information in penumbral tissue prior to infarction. The IVIM parameters were assessed to predict the onset of penumbral tissue death. Of the 3 IVIM parameters, f showed the best utility in predicting penumbral tissue death. |
| 4891 | Booth 4
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Hypertension is Associated with Intracranial Atherosclerotic Plaque Burden and Distribution: a MR Vessel Wall Imaging Study |
| Jiayu Xiao1, Jae W Song2, Steven Y Cen1,3, Fang Wu4, Xiao Liu5, Tao Jiang5, Konrad H Schlick6, Debiao Li7, Shlee S Song6, Qi Yang5, and Zhaoyang Fan1,8,9 | ||
1Radiology, Keck School of Medicine, Los Angeles, CA, United States, 2Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, United States, 3Neurology, Keck School of Medicine, Los Angeles, CA, United States, 4Radiology, Xuanwu Hospital, Beijing, China, 5Radiology, Beijing Chaoyang Hospital, Beijing, China, 6Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 7Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 8Radiation Oncology, Keck School of Medicine, Los Angeles, CA, United States, 9Biomedical Engineering, University of Southern California, Los Angeles, CA, United States |
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Hypertension is one of the most important modifiable risk factor for atherosclerosis. However, the association between blood pressure and intracranial plaque remains unclear. In this study, we investigated the impact of hypertension on intracranial plaque burden and distribution in 174 patients with recent ischemic stroke. Systolic blood pressure and diastolic blood pressure were independently associated with a higher total plaue burden as well as higher plaque counts at the proximal and junctional locations. These findings suggest hypertension may influence not only the count burden but also the distribution of intracranial plaque development. |
| 4892 | Booth 5
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Predicting Hematoma Expansion after Spontaneous Intracranial Hemorrhage Through a Magnetic Resonance-Based Radiomics Model |
| Samantha E Seymour1, Ryan A Rava1, Mitchell T Chudzik1, Kenneth V Snyder1,2,3, Muhammad E Waqas1,3, Jason M Davies1,2,3,4, Elad E Levy1,2,3, Adnan E Siddiqui1,2,3, Xiaoliang E Zhang5, and Ciprian E Ionita1,2,3,6 | ||
1Canon Stroke and Vascular Center, Buffalo, NY, United States, 2Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, United States, 3Department of Neurosurgery, University at Buffalo, Buffalo, NY, United States, 4Department of Bioinformatics, University at Buffalo, Buffalo, NY, United States, 5Department of Biomedical Engineering, University at Buffalo, Buffalo, NY, United States, 6Department of Biomedical Engineerinng, University at Buffalo, Buffalo, NY, United States |
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Intracranial hemorrhage (ICH) is bleeding within the cranium and occurs within the brain tissue, ventricles, and intracranial space. Hematoma expansion following an ICH has been related to increased mortality and morbidity inpatients. To detect ICH patients at risk, machine learning models can be used to predict whether or not hematoma expansion will occur. This study aims to assess the feasibility of machine learning prediction models using a radiomics approach. The highest sensitivity results indicated as 95% confidence intervals are 0.68 ± 0.004 and 0.72 ± 0.004, were achieved by support vector machine and logistic regression classifier models, respectively. |
| 4893 | Booth 6
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Detecting Residual Iron Contrast after Ferumoxytol Infusion in Cerebral Vasculature Using High-Resolution SWI at 7T |
| Li Jiang1, Yongsheng Chen2, Marco Muccio1, Chenyang Li1, Sagar Buch2, E Mark Haacke2, and Yulin Ge1 | ||
1NYU Grossman School of Medicine, New York, NY, United States, 2Wayne State University, Detroit, MI, United States |
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Ultra-small superparamagnetic iron oxides (USPIO) enhanced MRI has shown its great potential in detecting vascular abnormality in the brain on T2*-weighted sequences for better showing both macro- and micro-vasculature. In this study, we investigated the quantitative phase changes after Ferumoxytol infusion and examined its residual contrast in brain vasculature at 3-, 7- and 14-day follow-up SWI scans. To quantitatively measure the Ferumoxytol-induced susceptibility, the veins parallel to the main field were chosen for measurement. After measuring the intensity on high-pass filter phase images, the paired t-test showed a significant difference between pre-contrast and post-3d values from the follow-up visits. |
| 4894 | Booth 7
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Vessel Wall Imaging-Dedicated Automatic Processing Pipeline (VWI-APP): Towards Efficient and Reliable Intracranial Plaque Quantification |
| Hanyue Zhou1,2, Jiayu Xiao2, Dan Ruan1,3, and Zhaoyang Fan2,4,5 | ||
1Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 2Radiology, University of Southern California, Los Angeles, CA, United States, 3Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United States, 4Radiation Oncology, University of Southern California, Los Angeles, CA, United States, 5Biomedical Engineering, University of Southern California, Los Angeles, CA, United States |
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We propose an automatic pipeline for atherosclerosis plaque analysis based on magnetic resonance (MR) vessel wall imaging (VWI). The pipeline consists of five modules, i.e., 1) MR angiography (MRA) to VWI registration, 2) vessel centerline tracking, 3) vessel straightening and cross-sectional slices generating, 4) deep learning -based vessel wall and lumen segmentation, and 5) plaque quantification. The pipeline achieved good to excellent reliability for the clinically relevant plaque measures and largely reduced the analysis time required for physicians. |
| 4895 | Booth 8
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Iterative Refinement of Expert Contours for Improved Ground-truth Quality in Intracranial Vessel Segmentation Neural Network Training |
| Hanyue Zhou1,2, Jiayu Xiao2, Dan Ruan1,3, and Zhaoyang Fan2,4,5 | ||
1Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 2Radiology, University of Southern California, Los Angeles, CA, United States, 3Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United States, 4Radiation Oncology, University of Southern California, Los Angeles, CA, United States, 5Biomedical Engineering, University of Southern California, Los Angeles, CA, United States |
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With a typical slice-by-slice labeling fashion, the manual contouring process is subject to large intra-observer variation, especially for small-sized intracranial arteries. We propose an iterative refinement approach for ground truth contours with the help of deep neural networks for intracranial lumen and vessel wall segmentations. We demonstrate that the approach improved the smoothness of the predicted contours and feature quantification, which can potentially boost the robustness of a neural network as a consequence of the reduced uncertainty in expert labels. |
| 4896 | Booth 9
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Vessel Density Mapping of Brain Small Vessels on 3D High Resolution Black Blood MRI |
| Mona Sharifi Sarabi1, Samantha J Ma1,2, Danny JJ Wang1, and Yonggang Shi1 | ||
1University of Southern California, Los Angeles, CA, United States, 2Siemens Medical Solutions USA, Inc., Los Angeles, CA, United States |
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High resolution 3D black blood MRI with sub-millimeter spatial resolution has been proposed for visualizing small vessels of the brain. Here we present and evaluate a novel approach for mapping brain vessel density from 3D black blood images acquired at 3T. Using automated vessel segmentation and non-linear registration, localized detection and quantification of small vessel density is demonstrated to be feasible. This framework can potentially serve as a useful tool for detection and monitoring of localized vascular changes in aging and neurovascular disorders. |
| 4897 | Booth 10
|
Carotid atherosclerotic plaque segmentation in multi-weighted MRI using a two-stage neural network model |
| Ran Li1,2, Jie Zheng1,2, Pamela Woodard1,2, and Jha Abhinav1,2 | ||
1Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, United States, 2Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States |
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Our objective of this study is to accurately segment and classify carotid atherosclerotic plaque components in a completely automated manner, based on multi-weighted MRI. Specifically, we segmented each pixel using a two-module neural network model. Furthermore, we generated segmentation uncertainty maps with a Bayesian method to evaluate the inherent uncertainty of this segmentation task. |
| 4898 | Booth 11
|
Combined Modality PET/MR For the Detection of Severe Large Vessel Vasculitis |
| John Cerne1, Sophia Liu1, Muhammad Umair1, Ashitha Pathrose1, Hatice Savas1, Lisa Wilsbacher1, Jackson E Moore1, Michael Markl1, James Carr1, and Ryan Avery1 | ||
1Northwestern University, Chicago, IL, United States |
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Combined modality PET/MR may be a sensitive modality to detect severe large vessel vasculitis. To distinguish severe large vessel vasculitis, a qualitative review of PET imaging findings appears more useful than standardized uptake values of a patient’s highest-uptake vessel. Inflammatory marker levels and trends, as well as single-modality scan findings, were not significantly different between severe and non-severe large vessel vasculitis patients. |
| 4899 | Booth 12
|
Dynamic 3D T1 MRI method for T1-based Quantification of DCE for the Measurements of kinetic Parameters on Carotid Atherosclerotic Plaques |
| Seong-Eun Kim1, John A Roberts1, J. Scott MacNally1, Mathew Alexander 1, Gerald S Treiman2,3, Hediyeh Baradaran1, and Dennis L Parker1 | ||
1UCAIR, Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, 2Department of Surgery, University of Utah, Salt Lake City, UT, United States, 3VASLCHCS, Salt Lake City, UT, United States |
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This work introduced a reliable, comprehensive carotid DCE technique, including a high spatial and temporal resolution 3D dynamic T1 sequence and retrospective reconstruction methods to measure kinetic parameters on carotid atherosclerotic plaque. This technique can be used to evaluate the correlation between kinetic parameters and ischemic stroke. We believe that plaque kinetic parameters can be used in subsequent clinical trials as a changeable predictor of ischemic stroke risk. Clinicians could then use carotid DCE to monitor early response to medical therapy, and thereby improve detection and treatment of unstable carotid plaque and prevention of stroke. |
| 4900 | Booth 1
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On the optimization of 3D inflow-based vascular-space-occupancy (iVASO) MRI for the quantification of arteriolar cerebral blood volume (CBVa) |
| Chunming Gu1,2,3, Di Cao1,2,3, Xinyuan Miao2,3, Adrian G Paez2,3, Jitong Cai1, Yinghao Li1,2,3, Wenbo Li2,3, Jay J Pillai4,5, Peter C.M. van Zijl2,3, and Jun Hua2,3 | ||
1Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, 2Neurosection, Division of MRI Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 4Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States |
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The iVASO MRI is a noninvasive approach for quantitative mapping of CBVa in the brain. It was originally developed in the single-slice mode. Recently, CBVa measured by single-slice iVASO has been validated using histological markers of arteriolar blood vessels in a mouse model. Here, we demonstrate an optimized 3D iVASO MRI protocol with a 3D turbo-field-echo (TFE) readout and a whole-brain coverage. It showed consistent CBVa measures when compared to the original single-slice iVASO. In 3D-TFE-iVASO, the imaging slab volume did not show significant effects on the measured CBVa values. CBVa measured with 3D-TFE-iVASO showed reasonable intra-subject reproducibility. |
| 4901 | Booth 2
|
Evaluation of a Novel Manganese-Based Contrast Agent for Cardiac MRI in the Setting of Myocardial Ischemia-Reperfusion |
| Benjamin Pryor Bonner1,2,3, Jaume Coll-Font1,2,4, Salva Yurista1,2,4, Anna Foster1,2, Robert Eder1,2, Shi Chen1,2, Peter Caravan2,4, Eric Gale2,4, and Christopher Nguyen1,2,4,5 | ||
1Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States, 2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, 3Louisiana State University Health Sciences Center, New Orleans, New Orleans, LA, United States, 4Harvard Medical School, Boston, MA, United States, 5Division of Health Science Technology, Harvard-Massachusetts Institute of Technology, Cambridge, MA, United States |
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Cardiac MRI a powerful imaging modality to assess cardiac anatomy and function, and its utility can be greatly enhanced with the use of contrast agents. Conventional contrast agents are nephrotoxic which limits their utility. We evaluate a novel contrast agent which is safe for use in renal dysfunction. We compare its performance against that of a conventional agent a porcine model of ischemia-reperfusion. This novel contrast agent demonstrates equivalent performance in assessing myocardial fibrotic scars, indicating its potential clinical use in the workout of cardiac patients with renal impairment. |
| 4902 | Booth 3
|
Radial perfusion cardiac magnetic resonance imaging using deep learning image reconstruction. |
| Salah Assana1, Manuel Morales1, Kei Nakata1, Eiryu Sai1, Amine Amyar1, Hassan Haji-Valizadeh1, and Reza Nezafat1 | ||
1Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, MA, United States |
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Myocardial perfusion assessment using cardiac MRI allows non-invasive assessment of myocardial ischemia. In myocardial perfusion sequence, imaging is collected after a saturation pulse. An alternative approach based on steady-state imaging with radial sampling has been recently proposed. However, image reconstruction using compressed sensing in steady-state myocardial perfusion remains long and clinically not feasible. In this study, we sought to develop a deep learning-based image reconstruction platform for myocardial perfusion imaging. |
| 4903 | Booth 4
|
Analyzing CBF Connectivity Differences Affected by Hypertension in Arterial Spin Labelled Data Using Graph Theory |
| William D Reeves1, Ishfaque Ahmed1, Wenwu Sun1, Michelle Brown2, Celestine Williams2, Catherine L Davis2, Jennifer E McDowell3, Nathan Yanasak4, Shaoyong Su2, and Qun Zhao1 | ||
1Department of Physics, University of Georgia, Athens, GA, United States, 2Georgia Prevention Institute, Augusta University, Augusta, GA, United States, 3Department of Psychology, University of Georgia, Athens, GA, United States, 4Department of Radiology and Imaging, Augusta University, Augusta, GA, United States |
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In a cross-sectional study of hypertension and its effects on brain connectivity, graph theory can be used to show cerebral blood flow connectivity differences between normotensive (n=32) and hypertensive (n=37) subjects. We obtain adjacency matrices from processed arterial spin labelling scans which can be used to determine several quantifications based on graph theory analysis. We find that normotensive subjects exhibit higher small-worldness and global efficiency (σ = 3.30 and Eglob = 0.73) compared to hypertensive subjects (σ = 1.82 and Eglob = 0.46). This trend continues for nearly all thresholding values and implies a measurable perfusion difference between the groups. |
| 4904 | Booth 5
|
Parametric ATT and CBF Mapping Using a Three-Dimensional Convolutional Neural Network |
| Donghoon Kim1,2, Megan Lipford3, Hongjian He4, Qiuping Ding4, Vladimir Ivanovic2, Samuel Lockhart5, Suzanne Craft5, Christopher T. Whitlow3, and Youngkyoo Jung1,2,3 | ||
1Biomedical Engineering, University of California, Davis, CA, United States, 2Radiology, University of California, Davis, CA, United States, 3Radiology, Wake Forest University, Winston-Salem, NC, United States, 4Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Zhejiang, China, 5Internal Medicine, Wake Forest University, Winston-Salem, NC, United States |
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A CNN algorithm was proposed to estimate ATT and CBF simultaneously, using multi-TI ASL, acquiring ASL images at multiple PLDs. Hierarchical structure of CNN was used to reduce the estimation error of ATT and CBF. The proposed method successfully estimated ATT and CBF maps using reduced numbers of TIs or averages with a higher accuracy than a conventional non-linear model fitting. The successful estimation of ATT and CBF using our H-CNN may allow a total scan time reduction with a smaller number of TIs or averages and improvements of image quality when a part of acquisition is corrupted. |
| 4905 | Booth 6
|
Resting-state based Cerebrovascular Reactivity (CVR) mapping at high spatial resolutions |
| Lincoln Kartchner1, Dengrong Jiang2, Parimal Joshi1, Cuimei Xu2, Hanzhang Lu2, and Peiying Liu1 | ||
1Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States |
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Cerebrovascular reactivity (CVR) is typically assessed with a carbon dioxide (CO2) stimulus combined with BOLD fMRI. Recently, resting-state BOLD fMRI has been shown capable of generating CVR maps, providing a potential for broader CVR applications in neuroimaging studies. However, prior RS-CVR studies have primarily been performed at a spatial resolution of 3-4mm3 voxel sizes. It remains unknown whether RS-CVR can also be obtained at high-resolution without major degradation in image quality. In this study, we investigated the feasibility of high-resolution CVR mapping based on resting-state fMRI data. Our results showed good CVR quality can be obtained at 2-3mm3 voxel sizes. |
| 4906 | Booth 7
|
Normalization for Relative Cerebrovascular Reactivity in Multifocal Vascular Disease Patients Using Calibrated Perfusion and Temporal Shift |
| Xiuyuan Wang1, Siddhant Dogra2, Koto Ishida3, Alejandro Gupta2, Deqiang Qiu4, and Seena Dehkharghani2,3 | ||
1Department of Radiology, Weill Cornell Medicine, New York, NY, United States, 2Department of Radiology, New York University Langone Health, New York, NY, United States, 3Department of Neurology, New York University Langone Health, New York, NY, United States, 4Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States |
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Cerebrovascular reactivity (CVR) is a widely used estimation of hemodynamic stress and ischemic stroke risk but its semi-quantitative nature relegates it primarily to estimations of relative change by comparison to putatively normal territories. Diagnostic and prognostic utility is thus attenuated in commonly encountered patients with bihemispheric disease, thus we have tested approaches for identification of candidate healthy voxels accompanying perfusion imaging or inline calibration of BOLD temporal shift, optimized in a cohort of subjects with strictly unilateral macrovascular disease. Excellent agreement with normative CVR values was observed, suggesting its applicability in patients with multi-focal or ambiguous vascular disease patterns. |
| 4907 | Booth 8
|
Comparison of Velocity Selective ASL and PCASL with Phase-Contrast MRI for Measuring CO2-induced Cerebrovascular Reactivity |
| Feng Xu1,2, Cuimei Xu1, Dapeng Liu1,2, Dan Zhu2, Hanzhang Lu1,2, and Qin Qin1,2 | ||
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States |
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Saturation based velocity-selective ASL (VSASL) was recently investigated for acetazolamide challenge and notably lower cerebrovascular reactivity (CVR) was observed when comparing to PET results. Here we compared the performance of velocity-selective inversion (VSI) prepared ASL and pseudo-continuous ASL in response to the hypercapnia challenge for CO2-induced CVR quantification with phase-contrast MRI as a global reference. VSI-ASL could underestimate the regional CVR when the trailing edge of the labeled bolus arrive before the PLD as the CBF during hypercapnia would be underestimated. In contrast, PCASL could overestimate CVR in areas with long ATT as the baseline CBF would be underestimated. |
| 4908 | Booth 9
|
MR Multitasking-based Dynamic Imaging for Cerebrovascular Evaluation (MT-DICE): A Simulation Study for Accuracy Validation |
| Zhehao Hu1,2, Nan Wang3, Anthony Christodoulou2,3, Mark Shiroishi1, Gabriel Zada4, Debiao Li2,3, and Zhaoyang Fan1,5,6 | ||
1Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 4Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 5Department of Radiation Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 6Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States |
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MR Multitasking-based Dynamic Imaging for Cerebrovascular Evaluation (MT-DICE) technique is recently developed and has the potential to provide DCE- and leakage-corrected DSC-MRI parameters simultaneously with one 7.6-minute scan and a single-dose contrast injection. However, it remains a practical challenge to validate the technique against their respective references with repeated contrast injections in separate days. In this work, we perform a numerical simulation study to validate the accuracy of MT-DICE in the estimation of permeability and leakage-corrected perfusion metrics. |
| 4909 | Booth 10
|
Cerebral Blood Flow Patterns in Term and Premature Neonates measured at Term-Equivalent-Age: a PCASL study |
| Antonio Maria Chiarelli1, Eleonora Piccirilli1, Carlo Sestieri1, Daniele Mascali1, Emma Biondetti1, Antonio Ferretti1, Richard Wise1, and Massimo Caulo1,2 | ||
1Department of Neuroscience, Imaging and Clinical Sciences, University G. D'Annunzio of Chieti Pescara, Chieti, Italy, 2Department of Radiology, SS. Annunziata University Hospital, Chieti, Italy |
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During the perinatal period the brain undergoes extensive development, including increasing brain perfusion and metabolism. More rapidly modifying brain areas may be more sensitive to insults and transient hypoxic states. We performed PCASL on 115 infants at term equivalent age (TEA) with variable gestational age at birth. Insular-subcortical and somato-motor regions exhibited high grey matter CBF(GM) in both term and preterm newborns. However, premature neonates showed a redistribution of perfusion compared to term infants, with somato-motor regions showing even higher CBFGM. These results suggest that insular-subcortical and somato-motor regions may reflect brain health and development at TEA. |
| 4910 | Booth 11
|
Deep learning DCE-MRI parameter estimation: Application in pancreatic cancer |
| Tim Ottens1, Sebastiano Barbieri2, Matthew Orton3, Remy Klaassen4, Hanneke van Laarhoven4, Hans Crezee5, Aart Nederveen1, and Oliver Gurney-Champion1 | ||
1Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 2Centre for Big Data Research in Health, Sydney, Australia, 3Radiology, The Royal Marsden NHS Foundation Trust and The Institute for Cancer Research, London, United Kingdom, 4Medical Oncology, Amsterdam UMC, Amsterdam, Netherlands, 5Radiation Oncology, Amsterdam UMC, Amsterdam, Netherlands |
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Quantitative physiological perfusion parameters can be obtained from dynamic contrast-enhanced (DCE)-MRI. Conventionally, fitting is done with the non-linear least squares (NLLS) approach. However, the NLLS-fit suffers from long processing times and results in noisy parameter maps. In this work, we implemented a physics-informed gated recurrent unit (GRU) network with attention layers for estimating physiological parameters using the extended Tofts model. In simulations, we show it outperforms NLLS with more accurate and precise parameter maps. We show our method produced substantially less noisy parameter maps than NLLS in a fraction of the time in pancreatic cancer patients. |
| 4911 | Booth 12
|
Open source MATLAB code for the generation of digital reference objects for DCE-MRI analysis software validation |
| Andrew B. Gill1 and Martin J. Graves1 | ||
1Radiology, University of Cambridge, Cambridge, United Kingdom |
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Extending work by the QIBA initiative and others, a method is presented here for the generation of configurable digital reference objects (DROs) for the validation of dynamic-contrast enhanced (DCE-) MRI analysis software packages. Five commonly used kinetic models are supported and two software analysis packages were independently tested, one open source and one commercial. A sample set of DROs yielded excellent concordance with ‘ground-truth’ when analyzed with each package, indicating the software’s correctness and providing a benchmark for testing newly written software. Our MATLAB code is provided on an open-source basis to help researchers evaluate and test DCE-MRI analysis software. |
| 4912 | Booth 13
|
3D Inversion recovery-FLASH and myocardial perfusion MRI imaging in a sheep model of myocardial infarction |
| Steven KS Cho1, Jack RT Darby2, Georgia K Williams3, Catherine G Dimasi2, Stacey L Holman2, Joseph B Selvanayagam4, Christopher K Macgowan5, Janna L Morrison2, and Mike Seed6 | ||
1Physiology, University of Toronto, North York, ON, Canada, 2Early Origins of Adult Health Research Group, Health and Biomedical Innovation, University of South Australia, Adelaide, Australia, 3South Australian Health & Medical Research Institute, Preclinical, Imaging & Research Laboratories, Adelaide, Australia, 4Cardiac Imaging Research Group, Department of Heart Health, South Australian Health and Medical Research Institute, Flinders University, Adelaide, Australia, 5Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 6Division of Cardiology, The Hospital for Sick Children, Toronto, ON, Canada |
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We investigated the accuracy of cardiac MRI for detecting myocardial infarction (MI) induced by coronary artery ligation surgery in a sheep model. 3D-inversion recovery (IR) FLASH sequence and first-pass perfusion imaging was feasible and provided accurate information about the size and location of MI immediately after surgery and at 15-day follow-up. The IR-FLASH sequence detected infarcts (91.2% sensitivity, 99.9% specificity) compared with gold-standard pathology staining findings. This may prove useful for preclinical research in which it is important to document the natural history of myocardial injury, such as in studies investigating interventions aimed at mitigating the long-term impact of MI. |
| 4913 | Booth 1
|
Evaluation of Sex and Age Differences in Myocardial Microstructure using Cardiac Diffusion Tensor Imaging |
| Shi Chen1, Jaume Coll-Font1,2,3, Robert Eder1, Anna Foster 1, Salva Yurista 1,2,3, and Christopher T. Nguyen1,2,3,4 | ||
1Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, United States, 2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 3Harvard Medical School, Boston, MA, United States, 4Division of Health Science Technology, Harvard-Massachusetts Institute of Technology, Cambridge, MA, United States |
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Sexes and ages are known factors that contribute to cardiovascular pathophysiological variances and prognosis. This study used in-vivo cardiac diffusion tensor MRI (DT-MRI) to characterize how myocardial microstructure differs across sexes and ages. To that purpose, thirty healthy volunteers (14 female) were imaged with in-vivo cardiac DT-MRI and common DT-MRI parameters (MD, FA, HAT, E2A) were computed within the left ventricle (LV). No significant sex-related differences (11%, 9%, 3%, 9% respectively for MD, FA, HAT, E2A at septal regions) or age-related correlations were found. Taken together, sex and age had no effects on the quantification of in-vivo cardiac DT-MRI parameters. |
| 4914 | Booth 2
|
Manifold-based Respiratory Phase Estimation Enables Motion and Distortion Correction of Free-Breathing Cardiac Diffusion Tensor MRI |
| Jaume Coll-Font1,2,3, Shi Chen1, Robert Eder1, Yilin Fan4, Qiao Joyce Han1, Maaike van den Boomen1,2,3, David Sosnovik1,2,3, Choukri Mekkaoui2,3, and Christopher T. Nguyen1,2,3 | ||
1Cardiology, Massachusetts General Hospital, Charlestown, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 4Massachusetts Insitute of Technology, Cambridge, MA, United States |
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For in-vivo cardiac diffusion-tensor MRI (DT-MRI), respiratory motion and B0 field inhomogeneities produce misalignment and geometric distortion in diffusion weighted images acquired with conventional single shot echo planar imaging. We propose using Laplacian Eigenmaps (LE), a dimensionality reduction method, to retrospectively estimate the respiratory phase of DWI and facilitate both distortion correction (DisCo) and motion compensation (MoCo). LE-based DisCo and MoCo reduces geometric distortion by 13.2% while producing computationally efficient image alignment. Furthermore, preliminary results indicate the LE-based DisCo and MoCo can be applied with only acquiring a single set of b-value averages. |
| 4915 | Booth 3
|
Cine MRI detects shorter cardiac rest periods in pulmonary hypertension |
| Kai Lin1, Roberto Sarnari1, Ashitha Pathrose1, Daniel Gordon1, Michael Markl1, and James Carr1 | ||
1Radiology, Northwestern University, Chicago, IL, United States |
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The existence of pulmonary hypertension (PH) can independently shorten the length of cardiac rest periods. The length of cardiac rest periods can be used to discriminate PH patients from healthy controls. |
| 4916 | Booth 4
|
A Comparison of the Magnetic Force of MR-Conditional Cardiac Implants |
| Mabel Shehada1, Emile Shehada2, Ramez Shehada3, and David Prutchi4 | ||
1UCSD, San Diego, CA, United States, 2Yale University, New haven, CT, United States, 3Medical Technology Laboratories, La Mirada, CA, United States, 4Impulse Dynamics, MARLTON, NJ, United States |
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For implant systems composed of an implantable pulse generator (IPG) and lead(s), the MR-Conditional labeling specifies a magnetic spatial gradient for the whole system but not for its individual components. To identify the component experiencing the highest magnetic force, thus dictating the safe limit, we measured multiple IPGs and leads per ASTM F2052-15. The highest force on leads under 4.77T/m, 20T/m, and 50T/m was 0.003N, 0.021N, and 0.053N, respectively. The lowest IPG forces were 0.080N, 0.529N, and 1.322N. For any magnetic spatial gradient, the lowest IPG force was 2,480% greater than the highest lead force. |
| 4917 | Booth 5
|
Venc Scouting with a Whole Volume Fourier Velocity Encoding Spectrum Acquisition |
| Michael Loecher1,2 and Daniel B Ennis1,2,3 | ||
1Radiology, Stanford University, Stanford, CA, United States, 2Radiology, Veterans Administration Health Care System, Palo Alto, CA, United States, 3Cardiovascular Institute, Stanford University, Stanford, CA, United States |
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We explored the application of acquiring Fourier Velocity Encoding (FVE) without spatial encoding to quickly estimate the velocity distribution within a volume of interest. One application is to allow for quick selection of Venc for a subsequent 4D-Flow acquisition, which can limit velocity aliasing and fine-tune the velocity-to-noise ratio for better data quality. Other applications may include new ways of looking at the pulsatility or turbulence of a volume of interest. In this work we implement a FVE sequence in Pulseq and run it in flow phantoms to demonstrate the proof-of-concept data of this technique. |
| 4918 | Booth 6
|
Heart-brain MRI evaluation in one exam: a feasibility study in healthy aging adults |
| Kelly Jarvis1, Jackson E Moore1, Maria Aristova1, Ning Jin2, Valerie Torres1, Susanne Schnell1,3, Eric Russell1, Michael Markl1, Emily Rogalski4, and Ann Ragin1 | ||
1Radiology, Northwestern University, Chicago, IL, United States, 2Siemens Medical Solutions Inc., Cleveland, OH, United States, 3Medical Physics, University of Greifswald, Greifswald, Germany, 4Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, United States |
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Mechanisms underlying heart-brain hemodynamic coupling and effects on the brain remain unclear due to challenges of measuring both heart and brain in a single MRI exam. We have developed a comprehensive MRI protocol that incorporates 1) 4D flow MRI of chest, 2) 4D flow MRI of head and 3) structural neuroimaging into one MRI exam to assess cardiovascular and cerebrovascular flow as well as white matter lesions and brain atrophy. This study demonstrates the utility of heart-brain MRI as viable new tool for in vivo evaluation of hemodynamic coupling along the entire heart-brain pathway. |
| 4919 | Booth 7
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Effect of Knockout of Two Acetyl-CoA Carboxylase Isoforms in the Isolated Mouse Heart on Oxidation of Exogenous and Endogenous Energy Sources |
| Gaurav Sharma1, Chai-Wan Kim2,3, Xiaodong Wen1, A. Dean Sherry1,4,5, Chalermchai Khemtong1,6,7, Craig R. Malloy1,2,4, and Jay D. Horton2,3 | ||
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 5Department of Chemistry, University of Texas at Dallas, Richardson, TX, United States, 6Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, FL, United States, 7Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, United States |
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The product of acetyl-CoA carboxylase (ACC), malonyl-CoA, inhibits oxidation of long chain fatty acids by mitochondria. Cardiac-specific deletion of ACC-2 is associated with increased oxidation of fatty acids, as expected, the effects on glucose oxidation are controversial, and increased oxidation of stored triglycerides has been postulated. Expression of the other isoform, ACC-1, is preserved in ACC-2 mutant hearts, so alternative sources of malonyl-CoA may be important. We found that knock out of both isoforms was associated with a small increase in fatty acid oxidation, a small decrease in glucose oxidation, and little effect on oxidation of stored energy supplies. |
| 4920 | Booth 8
|
Preservation of Human Hearts for Transplantation: Comparison of Metabolic Indicators after Conventional and Temperature Controlled Storage |
| Gaurav Sharma1, Ryan J. Vela2, LaShondra Powell2, Stanislaw Deja3,4, Monika Mizerska3, Michael E. Jessen2, Shawn C. Burgess3,5, Craig R. Malloy1,6,7, and Matthias Peltz2 | ||
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, United States, 5Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 6Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States, 7Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States |
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Preservation of human hearts for transplantation is important to optimize outcomes. Standard ischemic cooling methods are intended to preserve high energy phosphates but risk tissue damage due to freezing; an alternative with precise temperature control has emerged as an option. The efficacy of this technique in preserving high energy phosphates and other metabolites has not been examined. We compared conventional cold storage to a commercial device with precise temperature control for preservation of human hearts not suitable for transplant. There were no significant differences in high energy phosphates or other metabolites using precise temperature control compared to conventional cold storage. |
| 4921 | Booth 9
|
Confirming conduction defect in fatty acid oxidation compromised heart using MRI strain imaging |
| El-Sayed H Ibrahim1, Jason Jarzembowski1, and Suresh Kumar1 | ||
1Medical College of Wisconsin, Milwaukee, WI, United States |
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Healthy heart is a metabolically dynamic organ requiring large energy resource, and fatty acid oxidation (FAO) pathway predominantly supports this energy demands. Disorders of FAO pathways could range from mild and manageable to severe and life-threatening. In this study, we use MRI to evaluate the heart function in mitochondrial trifunctional protein (MTP) mutant rats, where clinical symptoms of this disorder overlap with other less severe FAO deficiencies and are often misdiagnosed. The results showed that MRI strain imaging revealed subclinical cardiac dysfunction in the MTP mutant rats with the degree of strain reduction depending on strain direction and regional location. |
| 4922 | Booth 10
|
Test-Retest Reproducibility of Cerebrovascular Dual-venc 4D Flow MRI |
| Jackson E. Moore1, Kristina M. Zvolanek1, Maria Aristova1, Ramez Abdalla1, Ann Ragin1, Eric Russell1, Fan Caprio2, Sameer A. Ansari1, Susanne Schnell1,3, and Michael Markl1 | ||
1Radiology, Northwestern University, Chicago, IL, United States, 2Neurology, Northwestern University, Chicago, IL, United States, 3Institute of Physics, University of Greifswald, Greifswald, Germany |
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Cerebrovascular dual-venc 4D Flow MRI has utility in evaluating intracranial hemodynamics - benefitting from full circle of Willis (CoW) volumetric coverage, time-resolved, three-directional velocity encoding, and velocity dynamic range. Analysis of hemodynamic measures was completed using a comprehensive, semi-automated vessel identification and segmentation workflow for 10 subjects who underwent two scans within 30 days. Test-retest analysis of cerebrovascular dual-venc 4D Flow MRI and measures of CoW 3D flow dynamics demonstrated excellent repeatability for flow and peak velocity measures and lower reproducibility for pulsatility and resistive indices. Future work may include a larger cohort or more advanced analysis of velocity-derived parameters. |
| 4923 | Booth 1
|
A novel patient-adjustable coil technology substantially reduces RF heating of cardiac implantable electronic devices in pediatric patients |
| Bhumi Bhusal1, Fuchang Jiang1, Pia Panravi Sanpitak1, Boris Keil2, Gurinder Kaur Multani2, Nicolas Kutscha2, Giorgio Bonmassar3, Gregory Webster1, Andrada Popescu4, Daniel Kim1, and Laleh Golestanirad1 | ||
1Northwestern University, Chicago, IL, United States, 2TH Mittelhessen University of Applied Sciences, Giessen, Germany, 3Massachusetts General Hospital, Charlestown, MA, United States, 4Lurie Children's Hospital, Chicago, IL, United States |
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Infants and children with congenital heart disease may require cardiovascular implantable electronic devices (CIEDs), which typically precludes future evaluation by MRI due to risks associated with RF heating of implants. Here we demonstrate that a novel concept based on patient-adjustable rotating RF coil technology that was originally developed to reduce RF heating of brain implants can be adopted in pediatric patients with CIEDs to substantially reduce RF heating. Our simulations in a cohort of children with both epicardial and endocardial devices showed an 87% reduction in average SAR compared to conventional body coils. |
| 4924 | Booth 2
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Motion Robust Segmented Delayed Enhancement MRI by Partially Reversed ReOrdering for GeneRal SupprESSion of Motion Induced Variable Errors |
| Wolfgang G Rehwald1,2, Rafael Rojas2, Nestor Mena2, Ryan Seward2, George Gamoneda2, Jeana Dement2, Elizabeth Jenista2, David Wendell2, Han Kim2, Enn-Ling Chen2, Igor Klem2, Vera Kimbrell2, and Raymond Kim2 | ||
1Siemens Healthineers, Durham, NC, United States, 2Duke Cardiovascular MR Center, Duke University, Durham, NC, United States |
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Standard segmented delayed enhancement (DE) is particularly motion sensitive owing to its interleaved reordering required for inversion recovery (IR). Ghosting artifacts frequently result from imperfect breath holding. The sequence cannot run free-breathing (FB). We present a novel DE technique, PROGRESSIVE, using a partially continuous reordering and dummy pulses for simultaneous motion robustness and IR-compatibility. We tested PROGRESSIVE in simulations, a motion phantom, and a cohort of patients. PROGRESSIVE images were devoid of ghosting. When acquired FB, quality was significantly better than standard DE, and equally good during perfect breath holding. PROGRESSIVE has the potential for FB self-navigated DE imaging. |
| 4925 | Booth 3
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Comprehensive MRI reveals compromised baseline cardiac function in lung cancer patients undergoing radiation therapy treatment |
| El-Sayed H Ibrahim1, Elizabeth Gore1, Sherry-Ann Brown1, and Carmen Bergom2 | ||
1Medical College of Wisconsin, Milwaukee, WI, United States, 2Washington University, St Louis, MO, United States |
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Along with systemic therapies, radiation therapy (RT) plays a key role in treating lung cancer, despite high incidence of RT-induced cardiac complications. Most lung cancer patients present with cardiac risk factors that result in compromised baseline cardiac function that puts the patients at higher risk of developing cardiac complications. In this study, we investigate characteristics of baseline cardiovascular function in lung cancer patients undergoing RT. The results showed that the patients had borderline cardiac function and reduced myocardial strain measurements. Myocardial T1/T2 values in the patients were slightly high and the hemodynamic measurements showed different pattern than that in volunteers. |
| 4926 | Booth 4
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ECG-free 2D cardiac cine MRI with data-driven clustering |
| Zhengyang Ming1,2, Caroline M. Colbert1,2,3, Ruan Dan1,4, Holden H. Wu1,2, Anthony G. Christodoulou5, J. Paul Finn1,2, Peng Hu1,2, and Kim-Lien Nguyen1,2,3 | ||
1Physics and Biology in Medicine Graduate Program, University of California, Los Angeles, Los Angeles, CA, United States, 2Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 3Division of Cardiology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States, 4Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 5Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States |
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Conventional 2D cardiac cine imaging relies on ECG-gating whereas self-gated approaches mitigate ECG-dependency by assuming that cardiac motion is periodic with well-defined frequencies. This assumption breaks down when patients have irregular cardiac rhythm. We propose a segmented Cartesian golden step balanced steady-state free precession sequence (bSSFP) with motion navigators and a clustering algorithm to alleviate the dependency on regular motion assumptions and to emphasize the intrinsic similarity of mechanical motion. Compared to standard ECG-gated 2D bSSFP cine performed in normal sinus rhythm, initial validation using our approach achieved similar image quality and quantitative metrics for cardiac function.
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| 4927 | Booth 5
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DL-Based LV Volume Segmentation to Compare Respiratory-Corrected and 4D XD-GRASP Respiratory Motion-Resolved Whole-Heart Reconstructions |
| Yitong Yang1, Zahraw Shah2, Athira Jacob3, Jackson Hair1, Teodora Chitiboi3, Tiziano Passerini3, Jerome Yerly4, Lorenzo Di Sopra4, Davide Piccini5, Zahra Hosseini6, Puneet Sharma3, Anurag Sahu7, Matthias Stuber4, and John Oshinski1,8 | ||
1Biomedical Engineering, Emory University/Georgia Institute of Technology, Atlanta, GA, United States, 2Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, United States, 3Siemens Medical Solutions USA, Princeton, NJ, United States, 4Diagnostic and Interventional Radiology, Lausanne University Hospital, Lausanne, Switzerland, 5Siemens Healthcare, Lausanne, Switzerland, 6Siemens Medical Solutions USA, Atlanta, GA, United States, 7Cardiology, Emory University School of Medicine, Atlanta, GA, United States, 8Radiology, Emory University School of Medicine, Atlanta, GA, United States |
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Rapid and accurate quantification of left ventricular volume is essential for studying cardiac function. In this work, two reconstruction techniques for free-breathing, ECG-gated, radial, golden-angle phyllotaxis acquisition of whole-heart CMR are assessed for their accuracy in quantifying left ventricular volume using deep learning (DL)-based automatic cardiac chamber segmentation. The off-line reconstruction that resolves 4D (3D+respiratory) images had better agreement between the DL-based segmentation and an expert’s manual segmentation than the in-line reconstruction that corrects for respiratory motion, as assessed by the average volume difference (p=0.026) and 3D Dice coefficients (p=0.032). |
| 4928 | Booth 6
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Improved strain analysis of cine images by deep learning from DENSE: Comparison of a 3D Unet and an optical-flow net |
| Yu Wang1, Changyu Sun1, Sona Ghadimi1, Auger C. Daniel1, Pierre Croisille2,3, Magalie Viallon2,3, Jie Jane Cao4, Yang Joshua Cheng4, Andrew D. Scott5,6, Pedro F. Ferreira5,6, John N. Oshinski7, Daniel B. Ennis8, Kenneth C. Bilchick9, and Frederick H. Epstein1,10 | ||
1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 2University of Lyon, UJM-Saint-Etienne, INSA, CNRS UMR 5520, INSERM U1206, CREATIS, Saint-Etienne, France, 3Department of Radiology, University Hospital Saint-Etienne, Saint-Etienne, France, 4St. Francis Hospital, DeMatteis Center for Research and Education, Cardiac Imaging, Greenvale, NY, United States, 5Cardiovascular Magnetic Resonance Unit, The Royal Brompton Hospital, London, United Kingdom, 6National Heart and Lung Institute, Imperial College, London, United Kingdom, 7Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 8Department of Radiology, Stanford University, Stanford, CA, United States, 9Cardiovascular Division, Department of Medicine, University of Virginia Health System, Charlottesville, VA, United States, 10Radiology, University of Virginia, Charlottesville, VA, United States |
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Cine DENSE provides both myocardial contours and intramyocardial displacements. We propose to use DENSE to train deep networks to predict intramyocardial motion from contour motion. Two workflows were implemented: a two-step FlowNet2-based framework with a through-time correction network and a 3D (2D+t) Unet framework. Both networks depicted cardiac contraction and abnormal motion patterns. The 3D Unet showed excellent reliability for global circumferential strain (Ecc) and good reliability for segmental Ecc, and it outperformed commercial FT for both global and segmental Ecc. |
| 4929 | Booth 7
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Accelerated Cardiac MR Imaging with Inline Cascaded Parallel Imaging and Generative Adversarial Neural Network (PI-GAN) Framework |
| Siyeop Yoon1, Xiaoying Cai1,2, Eiryu Sai1, Salah Assana1, Amine Amyar1, Kelvin Chow3, Amanda Paskavitz1, Julia Cirillo1, Warren J. Manning1, and Reza Nezafat1 | ||
1Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States, 2Siemens Medical Solutions USA, Inc., Boston, MA, United States, 3Siemens Medical Solutions USA, Inc., Chicago, IL, United States |
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We developed and evaluated an inline cascaded parallel imaging and generative adversarial network for cardiac MRI. The preliminary results show excellent image quality of the cardiac cine images in four heat-beat. |
| 4930 | Booth 8
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MRI-derived contractility index as an early measure of thoracic radiation therapy-induced subclinical cardiotoxicity |
| El-Sayed H Ibrahim1, John Baker1, and Carmen Bergom2 | ||
1Medical College of Wisconsin, Milwaukee, WI, United States, 2Washington University, St Louis, MO, United States |
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Radiation therapy (RT) plays an integral role in treating a number of thoracic cancers, despite risks of radiation-induced cardiotoxicity. The purpose of this study is to investigate the capability of advanced the MRI-generated contractility index (ContractiX) for early detection of RT-induced cardiotoxicity in a pre-clinical rat model of thoracic cancer RT. While EF increased post-RT, peak systolic strain and ContractiX significantly decreased post-RT, with more relative reduction in ContractiX compared to strain. Therefore, ContractiX is a sensitive early marker for detection of subclinical cardiac dysfunction post-RT in pre-clinical models. |
| 4931 | Booth 1
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Cerebral Amyloid Angiopathy (CAA) is associated with higher R2 relaxation rate: An ex-vivo MRI and pathology study |
| Md Tahmid Yasar1, Mahir Tazwar 1, Ashish A. Tamhane2, Arnold M. Evia2, David A. Bennett2, Julie A. Schneider2, and Konstantinos Arfanakis1,2 | ||
1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States |
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Cerebral amyloid angiopathy (CAA) is characterized by deposition of amyloid-β protein in the walls of cortical and leptomemingeal small vessels. CAA is common in community-based older adults and has been associated with cognitive decline and dementia. To date, the association of CAA with the transverse relaxation rate, R2, remains unknown. This study in a large number of autopsied brains from community-based older adults showed for the first time that CAA is associated with higher R2, independent of other neuropathologies and demographic factors. The spatial pattern for this association derived from voxel-wise analysis included subcortical and frontal lobe structures. |
| 4932 | Booth 2
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Evaluating the clinical significance of MRI findings of Brain Herniations into Arachnoid Granulations in patients with pulsatile tinnitus |
| Justin Remer1, Eric Smith1, Javier Villanueva-Meyer1, Laura B Eisenmenger2, M. Travis Caton1, Amanda Baker1, Vinil Shah1, Karl Meisel3, Adelyn Tu-Chan3, and Matthew Amans1 | ||
1Radiology, UCSF, San Francisco, CA, United States, 2Radiology, University of Wisconsin, Madison, WI, United States, 3Neurology, UCSF, San Francisco, CA, United States |
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Pulsatile tinnitus, a severely debilitating condition where a “whooshing” sound is heard with each heart beat, affects over 3 million Americans, leading to anxiety, depression and even suicide. While many there are many diseases associated with pulsatile tinnitus one common and serious condition is idiopathic intracranial hypertension. Our study is the first to show that the presence of brain herniations through arachnoid granulations into dural sinuses on MRI is significantly associated with idiopathic intracranial hypertension in patient's with pulsatile tinnitus. |
| 4933 | Booth 3
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A randomized controlled trial of statins to reduce inflammation in cerebral aneurysms using vessel wall MRI |
| Chengcheng Zhu1, Huibin Kang2, Decai Tian3, Mahmud Mossa-basha1, Michael Levitt4, David Hasan5, Xinjian Yang2, and Yisen Zhang2 | ||
1Radiology, University of Washington, Seattle, WA, United States, 2Neurosurgery, Tiantan Hospital, Beijing, China, 3Neurology, Tiantan Hospital, Beijing, China, 4Neurosurgery, University of Washington, Seattle, WA, United States, 5Neurosurgery, University of Iowa, Iowa, IA, United States |
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Aneurysm wall enhancement as shown on contrast-enhanced vessel wall MRI (VW-MRI) is a surrogate biomarker of intracranial aneurysm (IA) wall inflammation, and it is associated with IA symptoms, growth, and rupture. However, it hasn't been used in clinical trails for UIA treatment. We performed the first prospective randomized controlled trial on the effect of statins for changes in aneurysm wall enhancement as shown in VW-MRI. We found that statins decreased aneurysm wall enhancement of UIAs in a short term of 6 months. Our results suggest VWI-MRI has great potential in future image-guided clinical trails to investigate novel treatment of IAs. |
| 4934 | Booth 4
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Vascular map assessment - the dual use of an analysis tool to evaluate imaging technique reproducibility and AI technique’s performance |
| Kaiyu Zhang1, Anders Gould2, Li Chen1, Zhensen Chen3, Gador Canton1, Niranjan Balu1, Thomas Hatsukami1, and Chun Yuan1 | ||
1Vascular Imaging Lab and BioMolecular Imaging Center, Department of Radiology, University of Washington, Seattle, WA, United States, 2Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana-Champaign, IL, United States, 3Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China |
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Intracranial artery feature extraction (iCafe), a custom-made semi-automatic vascular map construction software, can quantitatively measure intracranial vascular features on time of flight (TOF) MRA with good scan-rescan and inter/intra operator reproducibility. To fully extend the use of iCafe to a novel MRA technique named simultaneous non-contrast angiography and intraplaque hemorrhage (SNAP), we will first evaluate its vascular feature measurements reproducibility and then compare these measurements with those acquired with a newly developed AICafe (AI + iCafe) technique on the same dataset. Good reproducibility was obtained on SNAP MRA using iCafe, as well as the AICafe technique. |
| 4935 | Booth 5
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Characterization of a novel rodent model of arteriovenous malformations (AVMs) with time-of-flight magnetic resonance angiography |
| Chul Han1, Gregory Harrison Turner2, Candice Nguyen1, Michael Lawton1, and S. Paul Oh1 | ||
1Barrow Aneurysm and AVM Research Center, Barrow Neurological Institute, Phoenix, AZ, United States, 2Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States |
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A mouse model of arteriovenous malformations was developed with a genetics-based approach that conditionally deleted the causative activin receptor-like kinase 1 (ACVRL1 or ALK1) gene. This model was characterized in vivo using time-of-flight angiography (TOF_MRA). We correlated radiographic and histopathologic findings and determined that the 55 Tagln-Cre (+);Alk12f/2f mouse was a promising experimental brain AVM model for future studies of AVM pathophysiology, growth, rupture, and therapeutic regression. |
| 4936 | Booth 6
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PET Synthesis from Multi-Contrast MRI with Attention-Based 3D Encoder-Decoder Networks |
| Ramy Hussein1, David D. Shin2, Moss Zhao1, Jia Guo3, Michael Moseley1, and Greg Zaharchuk1 | ||
1Radiology, Stanford University, Stanford, CA, United States, 2Global MR Applications & Workflow, GE Healthcare, Menlo Park, CA, United States, 3Department of Bioengineering, University of California Riverside, Riverside, CA, United States |
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We present an attention-based 3D convolutional encoder-decoder network to synthetize PET Cerebral Blood Flow (CBF) maps from multi-parametric MRI images without using radioactive tracers. Inputs to the prediction model are structural MRI (T1 and T2 fluid-attenuated inversion recovery [FLAIR]), and arterial spin labeling (ASL) perfusion MRI images. Results show that encoder-decoder networks, with attention mechanisms and customized loss functions, can adequately combine multiple MRI image types and predict the gold-standard oxygen-15-water PET CBF maps. Adequate quantification of PET from MRI has a great potential for increasing the accessibility of cerebrovascular diseases assessment for underserved populations, underprivileged communities, and developing nations. |
| 4937 | Booth 7
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Implementation of OxFlow MRI with concurrent EEG for tracking the cerebral metabolic rate of oxygen during extended-duration scans of sleep |
| Alexander M Barclay1, Alessandra S Caporale1, Hengyi Rao1, Hyunyeol Lee2, Michael C Langham1, and Felix W Wehrli1 | ||
1University of Pennsylvania, Philadelphia, PA, United States, 2Kyungpook National University, Daegu, Korea, Republic of |
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OxFlow was used to track the global cerebral metabolic rate of oxygen (CMRO2) during wakefulness and sleep, with concurrent EEG, in eleven healthy subjects scanned continuously for 80 minutes. CMRO2 was derived from phase-contrast measurements of cerebral blood flow (CBF) in the neck with susceptometry-based oximetry measurements of venous oxygenation (SvO2) in the superior sagittal sinus (SSS). Results reveal that there is negligible bias between total CBF (tCBF), obtained by upscaling the value measured in the SSS, and CBF measured at the neck, suggesting that single-slice OxFlow can be implemented to simplify data acquisition and processing without sacrificing accuracy. |
| 4938 | Booth 8
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CAMWARE: Cascaded Multi-level Wavelet Refine Neural Network for Accelerated Whole-brain MR Vessel Wall Imaging |
| Zhehao Hu1,2, Alexander Lerner1, Roy Poblete3, and Zhaoyang Fan1,4,5 | ||
1Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 4Department of Radiation Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 5Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States |
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3D MR vessel wall imaging (VWI) is a non-invasive imaging modality for directly assessing intracranial arterial wall diseases. A typical intracranial VWI protocol requires 6-12 minutes per scan to obtain adequate spatial coverage and resolution. Such a long scan time hinders widespread use of VWI in clinical settings. We have developed a novel intracranial vessel-dedicated CAscaded Multi-level WAvelet REfine (CAMWARE) network that enables a VWI scan within 4 minutes. The proposed network achieved significant improvement in vessel wall delination over conventional compressed sensing reconstruction, and several state-of-the-art deep neural networks, such as U-Net and multi-level wavelet U-Net. |