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Online Gather.town Pitches - Physics & Engineering
Weekend and Oral

Digital Poster (no CME credit)

Online Gather.town Pitches (no CME credit)

ISMRT Educational Session

ISMRT Poster Presentations (no CME credit)

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Physics & Engineering Online Gather.town Pitches (No CME Credit)
Session Title

RF Coils, Technologies & Sequences I

Program # 3220 - 3238
Monday, 09 May 2022 | 09:15

New Systems & Devices I

Program # 3239 - 3251
Monday, 09 May 2022 | 09:15

RF Coils, Technologies & Sequences II

Program # 3310 - 3320
Monday, 09 May 2022 | 14:45

Safety, Low Field & Interventional I

Program # 3575 - 3585
Monday, 09 May 2022 | 17:00

New Systems & Devices II

Program # 3859 - 3872
Tuesday, 10 May 2022 | 09:15

New Systems & Devices III

Program # 3947 - 3953
Tuesday, 10 May 2022 | 14:30

RF Coils, Technologies & Sequences III

Program # 4101 - 4115
Tuesday, 10 May 2022 | 16:45

Safety, Low Field & Interventional II

Program # 4367 - 4374
Wednesday, 11 May 2022 | 09:15

RF Coils, Technologies & Sequences IV

Program # 4497 - 4511
Wednesday, 11 May 2022 | 16:45

Safety, Low Field & Interventional III

Program # 4818 - 4830
Thursday, 12 May 2022 | 14:45

New Systems & Devices IV

Program # 5023 - 5037
Thursday, 12 May 2022 | 17:00

New Systems & Devices V

Program # 5038 - 5050
Thursday, 12 May 2022 | 17:00

RF Coils, Technologies & Sequences I

Gather.town Space: South East
Room: 5
Monday 9:15 - 11:15
Physics & Engineering
Module : Module 24: RF Coils, Technologies & Sequences

3220
Booth 1
CoSimPy: an Open-Source Python Library for MRI RF Coil EM/Circuit Cosimulation
Umberto Zanovello1, Frank Seifert2, Oriano Bottauscio1, Lukas Winter2, Luca Zilberti1, and Bernd Ittermann2

1Istituto Nazionale di Ricerca Metrologica (I.N.Ri.M.), Torino, Italy, 2Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany

The Electromagnetic/Circuit cosimulation method represents an effective strategy to address those problems where a radiative structure has to interact with external supporting circuitries.This method proved to be particularly valuable for MRI RF coil design where the supporting circuitry optimisation is generally of particular concern. CoSimPy, an open-source library conceived for Electromagnetic/Circuit cosimulations, is presented. CoSimPy is written in Python following an Object-oriented programming. This improves its scalability and easily allows interested scientists to collaborate, integrating and improving the library with other methods. CoSimPy is available under https://github.com/umbertozanovello/CoSimPy together with a detailed documentation providing guidelines and examples.

3221
Booth 2
Head Coil for Vertical-Field MRI using Loop/Dipole Parallel RF Coils
Yosuke Otake1, Koichi Arai2, Takeshi Taniguchi2, Masayoshi Dohata2, Takahide Shimoda2, Kazuyuki Kato2, and Hisaaki Ochi1

1Innovative Technology Laboratory, FUJIFILM Healthcare Corporation, Tokyo, Japan, 2Radiation Diagnostic Systems Division, FUJIFILM Healthcare Corporation, Chiba, Japan

To improving the SNR and the g-factor in a vertical-field MRI, a multi-channel head coil has been developed. The coil consists of loop/dipole parallel RF coils (LDP) that improve the signal detection efficiency in the deep region of the subject in the vertical-field MRI. The performance of the coil was evaluated in a phantom experiment at 1.2T vertical-field MRI. The SNR and the g-factor of the coil using LDP were 1.2 and 1.2-2.9 times better than those of a conventional head coil, respectively. This technique will contribute to improve the performance of the vertical-field MRI.

3222
Booth 3
Investigation of a transmit coil to reduce the magnetic field strength in the proximity of a MR system
Daniel Durst1, Jürgen Nistler1, and Rainer Schneider1

1Siemens Healthcare GmbH, Erlangen, Germany

Birdcage coils used in MR imaging cause magnetic field strengths able to disturb electronic devices in the proximity to a MR system. Based on the principle of destructive superposition a configuration consisting of a main birdcage with additionally attached auxiliary birdcages is used to generate a field to reduce the magnetic field strength in the proximity of a MR system while maintaining the imaging quality. By electromagnetic simulations a reduction of up to 60 dB could be shown without drawbacks for the imaging performance if a distance of at least 25 cm between neighboring birdcages is retained.

3223
Booth 4
A quadrature birdcage/48-channel receiver coil assembly for human brain imaging at 5T
Zidong Wei1,2,3, Qiaoyan Chen1,2, Qiang He3, Xiaoliang Zhang4, Xin Liu1,2, Hairong zheng1,2, and Ye Li1,2

1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, shenzhen, China, 2Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, shenzhen, China, 3Shanghai United Imaging Healthcare, Shanghai, China, shanghai, China, 4Department of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY, United States

Ultra-high field magnetic resonance imaging (MRI) of human brain with high resolution has been increasing used for clinical and research applications. Due to RF transmit homogeneity and specific absorption issues, clinical use of ultra-high field MRI were limited. In this work, a local quadrature birdcage/48-channel receiver coil assembly was designed and evaluated on a novel whole body 5T MRI scanner. The coil at 5T showed improved SNR, higher parallel acceleration capability and improved detection in vessel wall imaging compared to a 32-channel coil at a 3T commercial scanner.

3224
Booth 5
Whole Spine Imaging at 5.0T Using An 8-channel Volume Transmit Coil and 48-channel Receive Array
Shao Che1,2,3, Fuyi Fang2, Kaida Dong2, Shihong Han2, and Ye Li1,3

1Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2United Imaging Healthcare, Shanghai, China, 3Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, Shenzhen, China

Large field-of-view imaging of spine in ultra-high field 5.0T magnetic resonance imaging system is achieved with RF hardware design of an 8-channel volume transmit coil and a dedicated posterior spine array of 48 receive channels. The axial coverage and transmit homogeneity allow the use of refocusing pulses under specific-absorption ratio limits by safety regulations. Consequent high-resolution fast spin echo clinical images are acquired and compared with results on a commercial 3.0T scanner.

3225
Booth 6
A 24-channel ultra-light flexible receiver coil array for human body imaging at 5T
Yingchao Tan1,2,3, Qiaoyan Chen1,2, Rui Zhao3, Hai Lu3, Xianwen Fan3, Junyu Chen3, Xin Liu1,2, Hairong Zheng1,2, and Ye Li1,2

1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, Shenzhen, China, 3Shanghai United Imaging Healthcare, Shanghai, China

To improve signal-to-noise ratio (SNR) and patient comfort, flexible coils need to be made of very light and flexible materials. In this study, a novel 24-channal ultra-light flexible receiver coil array was designed and constructed for human abdominal imaging at a 5T ultra-high field MRI system. The 24-channel ultra-light flexible coil showed much higher SNR and a better parallel acceleration capability compared to a 24-channel conventional receiver coil.  High quality human abdominal images were acquired by using the 24-channel ultra-light flexible coil.

3226
Booth 7
Design of ultrahigh dielectric constant uHDC helmet for 3T and its intrinsic resonance modes
Xinlian Chen1, Navid P. Gandji2, Christopher T. Sica2, Gary W. Yang3, Parisa Lotfi Poshtgol2, Hannes M Wiesner4, Xiao-Hong Zhu4, Michael Lanagan5, Wei Chen4, Qing X Yang2, and Xuegang Xin1

1Department of Biomedical Engineering, South China University of Technology, GuangDong, China, 2Departments of Neurosurgery and Radiology, College of Medicine, Pennsylvania State University, Hershey, PA, United States, 3Departments of Computer Science and Engineering, Pennsylvania State University, Hershey, PA, United States, 4Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 5Department of Engineering Science and Mechanics, Pennsylvania State University, Hershey, PA, United States

This investigation characterize the intrinsic resonance modes (IRM) in a helmet made from utrahigh dielectric constant (uHDC) material and their interactions with RF field produced by conventional array coils using numerical simulation. The RF field of the three lower order modes, TE, TM1 and TM2, were investigated.  TM1 mode produces uniform H-field in the transverse plane inside the helmet similar to that of a birdcage coil. TM2 mode produces a strong RF field but with a large gradient. Understanding of the IRMs of large uHDC structures such as helmets provides theoretical foundation for wider applications of uHDC materials RF engineering. 

3227
Booth 8
High isolation 8-channel pTx system for UHF MRI
Jifeng Chen1, Ye Li1, Jun Luo1, Xin Liu1, Xu Chu2, and Hairong Zheng1

1Lauterbur Imaging Research Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2United Imaging Healthcare, Shanghai, China

Ultra-high filed (UHF) whole-body MRI technique usually utilizes radio frequency power amplifier (RFPA) with high power rating [1,2]. It requires high isolation among transmission channels as well as between transmitting and receiving (T/R) circuits. It also requires high B1 homogeneity [3] and signal-to-noise ratio (SNR). On the premise of meeting the abovementioned requirements, this paper presents an 8-channel high power pTx architecture, which can support the whole-body MRI system with high isolation among transmission channels as well as between T/R circuits.

3228
Booth 9
Prostate imaging with Integrated Multi-modal Antenna with coupled Radiating dipoles (I-MARS) at 7T
Mingyan Li1, Jin Jin1,2, Ewald Weber1, Craig Engstrom 3, Aurelien Destruel1,4, Stuart Crozier1, and Feng Liu1

1School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia, 2Siemens Healthineers, Brisbane, Australia, 3School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia, 4The Center for Magnetic Resonance in Biology and Medicine, Aix-Marseille University, Marseille, France

Prostate imaging is challenging at 7T due to its small size seated deeply inside the pelvic region. As such, both transmit receive performance of the RF coils are heavily challenged. We have recently developed a new paddle-shape Integrated Multi-modal Antenna with coupled Radiating structures (I-MARS) allowing an ensemble of eight elements to be placed tightly together among each other and closely to the imaging region. In the current work, we demonstrate optimized work-flow and in vivo imaging results using such an 8-element paddle I-MARS coil with an upgraded MAGNETOM 7T Plus system.

3229
Booth 10
A dual-nuclei 1H/23Na knee coil for high-resolution 1H and 23Na MR imaging at 7T
xing yang1, Xin Liu1, feng du1, Nan Li1, Hairong Zheng1, and Ye Li1

1Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences, Shenzhen, China

 An ideal MRI study for early osteoarthritis should provide both structure imaging and functional imaging, which can show early morphologic degenerative changes and physiology changes of the cartilage. Most of previous dual-nuclei coils pushed the limits of non-proton nuclei sensitivity at the expense of 1H performance. To get high performance imaging for both nuclei, a novel dual-nuclei 1H/23Na coil array was developed. The bench test results show that all coils were sufficiently matched and decoupled, and the interference between sodium coils and proton coils was nearly negligible, thus can be expected to get high-resolution 1H imaging and quantitative 23Na imaging.

3230
Booth 11
Design of a double-layered quadruple-nuclear birdcage coil system for 1H / 19F / 23Na/31P MR imaging at 3T
Nan Li1,2, Feng Du1,2, Xiaoliang Zhang3, Xin Liu1,2, Hairong Zheng1,2, and Ye Li1,2

1Lauterbur Imaging Research Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, Shenzhen, China, 3Department of Biomedical Engineering, State University of New York, Buffalo, NY, United States

The lower natural abundance and gyromagnetic ratios of non-hydrogen nuclei require the use of a highly efficient RF coil to optimize the quality of the MR image and spectroscopy. In this study, a new quadruple-tuned RF coil system capable of 1H / 19F / 23Na /31P imaging was proposed, including the inner high-pass birdcage coil (31P) and a triple-tuned outer four-ring birdcage coil (1H / 19F / 23Na). The feasibility and performance of this proposed RF coil were evaluated and validated by the numerical electromagnetic simulation in the scattering parameters and B1+field distributions.

3231
Booth 12
Triple-nuclear RF coil system for Simultaneous acquisition of 1H / 19F / 23Na MR imaging at 3T
Nan Li1,2, Feng Du1,2, Xiaoliang Zhang3, Xin Liu1,2, Hairong Zheng1,2, and Ye Li1,2

1Lauterbur Imaging Research Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, Shenzhen, China, 3Department of Biomedical Engineering, State University of New York, Buffalo, NY, United States

The lower natural abundance and gyromagnetic ratios of non-hydrogen nuclei require the use of a highly efficient RF coil to optimize the quality of the image. In this study, a novel triple-nuclear RF coil system capable of 1H / 19F / 23Na imaging was designed. The coil consists of a triple-tuned four-ring birdcage transmit coil and the tight fit local X-nuclei single-loop receive coils. A range of bench tests were performed by using the developed triple-nuclear coil. The performance evaluations showed that the coil system was appropriately tuned, matched and decoupled at 1H/19F/23NA frequencies when working simultaneously.

3232
Booth 13
An 8-element torso RF coil array for the Australian inline MRI-Linac: Initial imaging results
Mingyan Li1, Ewald Weber1, David Waddington2, Shanshan Shan2, Paul Liu2, Bin Dong3, Craig Freakley1, Stuart Crozier1, and Feng Liu1

1School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia, 2ACRF Image X Institute, The University of Sydney, Sydney, Australia, 3Ingham Institute, Sydney, Australia

The hybrid MRI-Linac system demands dedicated radiolucent imaging coils to visualise and track tumours without interfering the Linac beams. A radiolucent whole-body transceive RF coil for the Australian inline MRI-Linac system has been previously developed and produced images with good quality. Recently, an 8-element torso RF coil array was manufactured to provide better SNR with fast imaging capability, which will facilitate real-time tumour tracking during radiotherapy. Initial imaging results acquired from the 1.0 T Australian MRI-Linac system on a phantom and a volunteer demonstrate the potential benefits of such a torso coil array for MRI-guided radiotherapies.

3233
Booth 14
A novel three-channel endorectal coil for prostate magnetic resonance imaging at 3T
Zhiguang Mo1, Xiaoliang Zhang2, Changjun Tie1, Huageng Liang3, Xiaoping Zhang3, Wen Xiao3, Qi Cao3, and Ye Li1

1Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China, Shenzhen, China, 2Department of Biomedical Engineering, State University of New York at Buffalo, NY, United States., Buffalo, NY, United Stats, Buffalo, NY, United States, 3Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

We designed and fabricated a novel three-channel endorectal prostate coil and validated its feasibility of high-resolution magnetic resonance imaging (MRI) at 3T. A commercial 3T surface coil was used for comparison. Both phantom imaging and in-vivo prostate imaging show that the 3-channel endorectal coil provides an improved SNR than the external surface coil. Prostate images at resolution of 0.47 mm × 0.47 mm × 4.0 mm are acquired using the 3-channel endorectal coil to demonstrate the performance. With the improved SNR and multichannel design, the proposed endorectal coil could enable parallel imaging based fast imaging in prostate imaging studies.  

3234
Booth 15
Combining High Permittivity Pads with Periodic Passive Components in RF Coil Design at 7T
Haiwei Chen1, Zhuang Xiong1, Lei Guo1, Xiaotong Zhang2, and Feng Liu1

1the University of Queensland, Brisbane, Australia, 2Zhejiang University, Hangzhou, China

Periodic passive components (PPC) such as metamaterials can improve SAR efficiency and B1 penetration. However, due to the shorter RF wavelength in MRI, the performance of PPC is confined by the limited number of unit cells. In this work, a novel PPC structure has been proposed to combine with a high permittivity pad (HPP), so a larger number of unit cells can be used. The designed structure is excited by a dipole coil and compared with the case when a single HPP is used. It is observed that more than 50% SAR reduction can be achieved.


3235
Booth 16
Multichannel MRI receive coil based on artificial material
Eugene Koreshin1, Denis Burov1, and Pavel Seregin1

1School of Physics and Engineering, ITMO University, Saint-Petersburg, Russian Federation

Metamaterials and metasurfaces, in particular, are gaining increasing popularity in recent years. One of the novel applications of metasurfaces are receive coils for magnetic resonance imaging. The major drawback of using such structures is the lack of parallel MRI capabilities due to the single-channel acquisition regime. In this work, we will demonstrate that it is possible to design a multichannel metasurface.

3236
Booth 17
Parallel transmission RF pulse design for simultaneous multi‐slab excitation at 7 Tesla: a simulation study
Xin Shao1, Xiaodong Ma2, Simin Liu1, Kamil Ugurbil2, Hua Guo1, and Xiaoping Wu2

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2Center for Magnetic Resonance Research, Radiology, Medical School, University of Minnesota - Twin Cities, Minneapolis, MN, United States

It has been reported that combining ultrahigh field (UHF) with 3D imaging is beneficial for high-resolution imaging. Nevertheless, image quality may suffer from increased magnetic field inhomogeneity. Thus, we combined radiofrequency (RF) parallel transmission (pTx) with 3D simultaneous multi-slab (SMSlab) acquisition at 7T to get improved transmit field and optimal SNR efficiency concurrently. By simulation, it was proved that by using a 3-spoke RF pulses we could get 25% more uniform excitation magnitude than 2-spoke pulses (with almost the same RF peak power and identical pulse duration).

3237
Booth 18
Bumped Self-decoupled RF Coil
Ming Lu1, John C. Gore2,3, and Xinqiang Yan2,3

1College of nuclear equipment and nuclear engineering, Yantai University, Yantai, China, 2Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 3Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

In this work, we propose a novel “bump” design to further improve the coil robustness versus loadings.  For the loop-mode self-decoupled coil, the rotating magnetic field (composed of Bx and By) and electric field are mainly determined by the feed and arm conductors; the frequency shift that decreases coil robustness is mainly caused by the conductor with small-valued mode capacitors (referred to as mode conductor for short). Therefore, a bumped coil with a spaced  mode conductor but unchanged arm and feed conductors potentially provides more robust tuning/matching performance without decreasing coil efficiency.

3238
Booth 19
Bore integrated coil for whole-body imaging at 7 Tesla based on patch antennas
Georgiy Solomakha1, Svetlana Egorova1, Alena Shchelokova1, Egor Kretov1, and Stanislav Glybovski1

1Department of Physics and Engineering, ITMO University, Saint Petersburg, Russian Federation

This work proposes a novel transmit radiofrequency coil integrated into the scanner bore for whole-body MRI for 7 Tesla MRI based on patch antennas. Numerical studies with a homogeneous phantom demonstrated 4.5-fold higher transmit efficiency in the phantom center compared to the state-of-the-art bore integrated stripline array.


New Systems & Devices I

Gather.town Space: South East
Room: 6
Monday 9:15 - 11:15
Physics & Engineering
Module : Module 32: New Systems & Devices

3239
Booth 1
High Accuracy Heartbeat Detection with 433MHz CW-Doppler Radar for MRI Application
Yuxin Wu1, John Pauly2, and Greig Scott2

1Department of Electronic Engineering, Tsinghua University, Beijing, China, 2Department of Electrical Engineering, Stanford University, Stanford, CA, United States

This work assesses heartbeat detection by continuous-wave (CW) Doppler radar using low and high carrier frequencies of 433MHz and 5GHz as options for non-contact vitals sensing in MRI.  The experimental results show that using the amplitude of received complex signals in low frequency 433MHz-detection can perform as well as 5GHz-detection due to near field interactions within a 20cm range, with similar heartbeat detection efficacy.

3240
Booth 2
MR microscopy of human embryo at high isotropic spatial resolution
Kazuyuki Makihara1, Kazuki Kunieda1, Shigehito Yamada2, Katsumi Kose3, and Yasuhiko Terada1

1Graduate School of Science and Technology, University of Tsukuba, Tsukuba, Japan, 2Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, 3MRI simulations Inc., Minato-ku, Japan

High-resolution MR microscopy is advantageous for the human embryo study, but had not been realized because of many challenges. In this study, we demonstrated high-resolution MR microscopy of a human embryo specimen with 18 µm isotropic resolution. To achieve the higher spatial resolution than the previous system, we improved the hardware and optimized the pulse sequence. The MR images of the embryo showed detailed anatomical structures and were similar in appearance to the stained images obtained from an embryo specimen at the same developmental stage.

3241
Booth 3
Design of a 5-channel local B0 shimming coil for rat brain imaging at 3T
Qiaoyan Chen1,2, Chao Luo1,2, Xiaoliang Zhang3, Xin Liu1,2, Hairong Zheng1,2, and Ye Li1,2

1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, Shenzhen, China, 3Department of Biomedical Engineering, State University of New York at Buffalo, New York, NY, United States

 To improve B0 magnetic field homogeneity and minimize interferences on RF coils, local shimming coils with a few channel number can be applied. In this study, we designed and constructed a 5-channel local B0 shimming coil for the rat brain. There was a marginal SNR loss within 5% after converting the local shimming coil into a 3-channel RF coil. The reduction of B0 inhomogeneity for the rat brain with respect to the basic set was about 34%. A large portion of the distortion in EPI images was recovered and some image artifacts were eliminated after using the local shimming coil. 

3242
Booth 4
Development of a Benchtop 7T cryogen-free animal MRI system
Yaohui Wang1, Qiuliang Wang1, Jigang Zhao1, Yang Liu1, Yijie Zheng1, Zhifeng Chen2, and Feng Liu3

1Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, China, 2USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 3School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia

A small-size, light-weight, cryogen-free 7T animal MRI system is being developed in IEE CAS. The magnet system has been completed and acceptable magnetic field strength and homogeneity indices have been achieved. The gradient assembly with passive shimming is going into the final assembly stage and the RF coil is ready for tunning. The integration of the whole system will be very soon and a mouse experiment will be conducted then. It is expected the ultimate product will largely boost the scientific research activities that are unapproachable to advanced MRI scanners.

3243
Booth 5
Deuterium metabolism imaging of rat brain at 9.4T using a double-nuclear transceiver
Feng Du1,2, Jiawen Yuan1,3, Nan Li1,2, Chao Zhou1,2, Qian Wan1,2, Qikai Qin4, Garth J. Thompson4, Qiong Ye5, Xiaoliang Zhang6, Xin Liu1,2, Hairong Zheng1,2, and Ye Li1,2

1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, Shenzhen, China, 3Southern University of Science and Technology, Shenzhen, China, 4iHuman Institute, ShanghaiTech University, Shanghai, China, 5High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China, 6Department of Biomedical Engineering, State University of New York, Buffalo, NY, United States

Deuterium metabolic imaging (DMI) is an emerging technique, which can measure the metabolism in the brain non-invasively after intake of deuterated glucose. In this work, we construct a versatile and dedicated 1H/2H dual-nuclear transceiver for a 9.4T pre-clinical research system. The performance of the transceiver was evaluated by measuring the in vivo 2H spectra data. The metabolites of water, glucose, Glx and lactate after glucose infusion were quantified in healthy and glioma rats using the constructed double-nuclear transceiver.

3244
Booth 6
A 2kW non-magnetic RF power amplifier with negative feedback for 5T MRI proton imaging
Jun Luo1,2,3, Shengping Liu1, Jifeng Chen2, and Ye Li2,3

1Chongqing University of Technology, Chongqing, China, 2Lauterbur Imaging Research Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 3Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, Shenzhen, China

Parallel transmission technology has attracted much attention because of its advantages of uniform excitation and artifact correction in ultra-high field. A 2kW non-magnetic prototype RF amplifier for 5T multi-channel parallel transmission (pTx) is presented. It is equipped with analogic feedback loops and provides a high linearity up to peak output power. It maintains excellent fidelity performance even without a circulator.

3245
Booth 7
Abdominal imaging at 5.0 Tesla: Preliminary results
Liyun Zheng1,2, Chun Yang3, Ruofan Sheng3, Yongming Dai2, and Mengsu Zeng1,3

1Shanghai Institute of Medical Imaging, Shanghai, China, 2United Imaging Healthcare, Shanghai, China, 3Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China

Higher magnetic field strength leads to an increase of the SNR. On the other hand, the increase of magnetic field strength implies larger magnetic susceptibility inhomogeneities. Recently, 5.0T whole body magnetic resonance imaging system has been introduced into research and clinical settings. In this study, we evaluated the feasibility of abdominal imaging at 5T and compared the image quality and potential artifacts with 3T. Our results indicated that 5T MRI is able to acquire artifact-free anatomical images of the abdomen. Compared to 3T MRI, abdominal MRI at 5T resulted in comparable image quality and better contrast ratios.


3246
Booth 8
Renal MRI at 5T: A feasibility and quantitative study
Liyun Zheng1,2, Chun Yang3, Ruofan Sheng3, Yongming Dai2, and Mengsu Zeng1,3

1Shanghai Institute of Medical Imaging, Shanghai, China, 2United Imaging Healthcare, Shanghai, China, 3Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China

Compared to clinical field strengths, MRI at ultra-high magnetic fields allows higher SNR. However, imaging at 7T remains challenging, especially in renal MRI. This study investigated the feasibility of renal MRI at 5T, with a brand new 5T MR scanner. Compared to 3T examination, 5T renal MRI demonstrated higher SNR and improved corticomedullar discrimination with diagnostic image quality. Functional imaging, including DWI and T2* mapping, was also feasible at 5T. Therefore, in vivo 5T renal MRI may better elucidate the renal diseases with both anatomical and functional imaging, compared to conventional clinical MRI scanners.


3247
Booth 9
Multiparametric MRI method development for clinical prostate imaging using 5T MR imaging
Liyun Zheng1,2, Chun Yang3, Ruofan Sheng3, Yongming Dai2, and Mengsu Zeng1,3

1Shanghai Institute of Medical Imaging, Shanghai, China, 2United Imaging Healthcare, Shanghai, China, 3Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China

Moving to higher magnetic field strength (> 3 T) may have clinical advantages because of an intrinsic increase of the signal-to-noise ratio (SNR), while heterogeneity in the transmit radiofrequency (RF) field or B1 can cause signal voids throughout images. This study aimed to evaluate the development of prostate MRI at 5T by providing assessment of image quality on clinical sequences, including T1W, T2W and DWI images. According to current results about image quality, present of artifacts, visibility of anatomical structures of T2W images, and geometric distortion of DWI images, clinical prostate imaging is feasible at 5T MRI.


3248
Booth 10
Morphological 5T MRI of hip in comparison to 3T: An initial study
Liyun Zheng1,2, Chun Yang3, Ruofan Sheng3, Yongming Dai2, and Mengsu Zeng1,3

1Shanghai Institute of Medical Imaging, Shanghai, China, 2United Imaging Healthcare, Shanghai, China, 3Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China

Imaging the hip cartilage using magnetic resonance imaging (MRI) is more challenging compared with other joints. The utilize of higher magnetic field strengths (>3T) is able to improve the assessment of cartilage structures in the hip. In this study we evaluated morphological 5T hip MRI in healthy subjects and compared image quality at 5T with 3T MRI. The results revealed that morphological 5T hip MRI in healthy subjects was superior to 3T MRI in image quality, visibility of the anatomical structures and contrast ratios.


3249
Booth 11
Transient Computations of Eddy-Currents Induced by an Amplitude-Modulated Sinusoidal Gradient Pulse
Sadeq S Alsharafi1, Haile Baye Kassahun1, Ahmed M Badawi1, and AbdEl-Monem M El-Sharkawy1

1Systems and Biomedical Engineering, Cairo University, Giza, Egypt

Eddy-currents are generated in MRI scanners’ metallic structures due to the rapid switching of gradient coils. They may result in image distortions and induce acoustic-noise particularly for fast/spiral sequences. Transient eddy-currents computations can be used to understand the extent of such effects. In this work, a numerical framework was devised to compute transient eddy-currents induced by an amplitude-modulated sinusoidal pulse for a longitudinal gradient coil configuration. Stream functions representation of eddy-currents, Multilayer Integral Method, and an excitation current with amplitude-modulated sinusoidal function are used to solve the circuit equation and efficiently compute transient eddy-currents generated in the cryostat.

3250
Booth 12
Actively Shielded Two-channel Transverse MRI Gradient Coil Numerical Design Using Discrete Wire Method
Haile Baye Kassahun1, Sadeq S Alsharafi1, Ahmed M Badawi1, and AbdEl-Monem M El-Sharkawy1

1Systems and Biomedical Engineering, Cairo University, Cairo, Egypt

A two-channel, self-shielded, cylindrical, transverse gradient coil is numerically designed. The four quadrants of both the inner and outer cylinders were each divided into two sections. All symmetric inner sections of the primary and corresponding shielding coil turns are assigned to the first channel where the outer enclosing sections belong to the second channel. Quasi-elliptic curves are used for coil tracks design. Achieving a comparable target gradient field, the DC dissipated power of a two-channel coil is lower compared to a conventional coil designed with similar dimensions and number of turns by at least 20%, thereby reducing ohmic losses.  

3251
Booth 13
Eddy-Currents Computations Using A Single-Layer Stream-Function Method
Sadeq s Alsharafi1, Haile Baye Kassahun1, Ahmed M Badawi1, and AbdEl-Monem M El-Sharkawy1

1Systems and Biomedical Engineering, Cairo University, Giza, Egypt

 Eddy-currents induced by MRI gradient coils due to rapid switching result in undesirable thermal effects, field distortions and acoustic-noise. Efficient numerical computations are needed to analyze eddy-currents for complex configurations. The skin-depth adds an extra computational burden for numerical eddy-current computations since meshing in the skin-depth direction may be needed to achieve reliable computations during harmonic analysis. Here, we use a single-layer stream-function method (SSM) applying resistance compensation and compare our results to a multi-layer integral method (MIM) approach. We show that SSM method achieves accurate comparable results relative to both MIM and Ansys albeit at higher computational effeciency.


RF Coils, Technologies & Sequences II

Gather.town Space: North East
Room: 3
Monday 14:45 - 16:45
Physics & Engineering
Module : Module 24: RF Coils, Technologies & Sequences

3310
Booth 1
A Dedicated Transceiver 8Tx/16Rx pTx Coil Array for Ex-vivo MRI Histology of Post-infarction Myocardium on a Whole-body 7T Scanner
Ibrahim A. Elabyad1, Maxim Terekhov1, and Laura M. Schreiber1

1Chair of Molecular and Cellular Imaging, Comprehensive Heart Failure Center (CHFC), University Hospital Wuerzburg, Wuerzburg, Germany

The purpose of this work was to develop and investigate a dedicated transceiver 16-element antisymmetric loop array for high-resolution imaging of the ex-vivo porcine heart at 7T. The array was interfaced to a 7T scanner in parallel transmit (pTx) mode (8Tx/16Rx). Electromagnetic-field (EMF) simulations were performed with the antisymmetric array loaded with a spherical phantom and a human heart (Billie). The optimization of the B1+-shimming for both sTx and pTx applications was performed using simulated and experimental B1-maps. The array was successfully tested to acquire ultra-high resolution (0.1x0.1x0.8mm voxel) images of the post-infarction scar tissue in the excised pig heart.

3311
Booth 2
A comparison of double-matching networks in a double-tuned coil for multinuclear MRI
Chang-Hoon Choi1, Suk-Min Hong1, Jörg Felder1,2, and N. Jon Shah1,3,4,5

1Institute of Neuroscience and Medicine - 4, Forschungszentrum Juelich, Juelich, Germany, 2RWTH Aachen University, Aachen, Germany, 3Institute of Neuroscience and Medicine - 11, Forschungszentrum Juelich, Juelich, Germany, 4JARA - BRAIN - Translational Medicine, Aachen, Germany, 5Department of Neurology, RWTH Aachen University, Aachen, Germany

X-nuclei MR offers unique information relating to cellular and metabolic processes in tissues. Multi-tuned coils are frequently utilised for X-nuclei measurements, and a number of novel approaches for double tuning coils exist. However, designing a well-performing multi-tuned coil is challenging, and making any improvement in SNR is particularly desirable on the X-nucleus coil due to the intrinsically lower MR sensitivity of X-nuclei. This study focuses on the insertion of double-matching networks in a single-structure, double-tuned 1H/23Na coil and compares their effect on the coil performance. The double-matching networks were built using either split or blocking traps.

3312
Booth 3
Neural Network-supported Fast Online-Customized (FOCUS) parallel transmit (pTx) pulses for slice-selective, large flip angle excitation
Jürgen Herrler1, Patrick Liebig2, Kurt Majewski3, Rene Gumbrecht2, Dieter Ritter2, Christian Richard Meixner4, Andreas Maier5, Arnd Dörfler1, and Armin Michael Nagel4,6

1Department of Neuroradiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 2Siemens Healthcare GmbH, Erlangen, Germany, 3Department of Corporate Technology, Siemens, München, Germany, 4Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 5Department of Computer Science, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 6Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Slice-selective, two-spoke parallel transmit (pTx) pulses for exciting large flip angles can be designed quickly and show robust performance for MRI at 7 Tesla using an 8Tx/32Rx coil. Firstly, clusters of B1+/B0 maps are defined and corresponding pulses are optimized prior to the scan. These serve as initialization for a fast, gradient-descent based online-optimization. For each slice, the best cluster-specific initialization is chosen online via neural networks, which predict their respective spatial distribution of the longitudinal magnetization. This approach outperforms other strategies to initialize the pTx RF pulses such as offline-optimized slab-specific and circularly polarized RF pulses as initializations.

3313
Booth 4
Direct Signal Control combined with dynamic, Fast Online Customized (FOCUS) parallel transmit excitation pulses for TSE at 7 Tesla
Jürgen Herrler1, Jonathan Endres1, Raphael Tomi-Tricot2,3,4, Patrick Liebig5, Rene Gumbrecht5, Christian Richard Meixner6, Andreas Maier7, Arnd Dörfler1, Shaihan Malik3,4, and Armin Michael Nagel6,8

1Department of Neuroradiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 2MR Research Collaborations, Siemens Healthcare Limited, London, United Kingdom, 3Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 4Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 5Siemens Healthcare GmbH, Erlangen, Germany, 6Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 7Department of Computer Science, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 8Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Direct Signal Control with Variable Excitation and Refocusing (DiSCoVER) was combined with a dynamic, Fast Online-Customized (FOCUS) parallel transmit excitation pulse for a 3D TSE sequence using an 8Tx/32Rx head RF coil at 7 Tesla. DSC could improve the signal, mainly in the cerebellum region compared to CP mode. FOCUS excitation pulses achieve better FA and phase homogeneity than static pTx pulses (standardly used in DiSCoVER). Combining a FOCUS excitation pulse with DiSCoVER-optimized refocusing pulses, led to signal gain across the echoes, which was evaluated in simulations for 132 subjects. Universal and individual DiSCoVER-refocusing pulses showed comparable performance.

3314
Booth 5
iDREAM: T1-bias compensated DREAM B1+ mapping using adiabatic inversion pulses
Kay Nehrke1 and Peter Börnert1

1Philips Research Laboratories, Hamburg, Germany

A refinement of the DREAM B1+ mapping technique is presented, that removes the potential T1-bias from the B1+ maps. It is based on a phase cycling scheme including adiabatic inversion pulses and improves the B1+ mapping accuracy and reliability and extends the dynamic working range of the DREAM approach. The method has been successfully validated on phantoms and in vivo on the brain at 3T.

3315
Booth 6
Optimization of the Double-Row 16-channel Transmit-only RF Array Coil for Human Brain Imaging at 9.4T.
Anton Nikulin1,2, Klaus Scheffler1,2, and Nikolai Avdievich2

1Department of Biomedical Magnetic Resonance, Eberhard Karls University Tübingen, Tübingen, Germany, 2Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany

At 9.4T, transmit-only RF array coils for human brain imaging provide mediocre transmit efficiency due to a weak loading factor, which implies low power dissipation in the tissues. In this work we aim to optimize using the full-wave simulations a dual row 16-channel transmit-only array to improve the transmit performance. For that purpose, we simulated eight different array designs containing the loops with overlapping and gaps between the rows and two configurations of loopoles. We have shown that the optimized design with the overlapped loops provides improvement ~15% in Tx-efficiency and 16.5% improvement in SAR-efficiency compared to the reference coil.

3316
Booth 7
Adjustable parabolic shape 8Tx/16Rx array for longitudinal cardiac MRI in large animals at 7T: proof of concept
Maxim Terekhov1, Ibrahim A. Elabyad1, and Laura M. Schreiber1

1Chair of Cellular and Molecular Imaging, Comprehensive Heart Failure Center, University Hospital Würzburg, Wuerzburg, Germany

Cardiovascular MRI at the ultra-high-field is an emerging modality promising a significant increase of the spatial resolution and physical sensitivity of routine cardiac imaging. Pig models play an important role in the establishment and translation of 7T cMRI to humans. The prerequisite for high-quality 7T cMRI data in pigs is dedicated transceiver arrays adapted to the shape of the pig’s thorax. We validated the proof-of-concept of the transceiver pTX cardiac array with adjustable parabolic shape housing for longitudinal studies with pigs. The stability of the transmit and receive characteristics by shape adjustments are tested in-silico and in phantom measurements.    

3317
Booth 8
A Flexible 16-Element Transceiver 8Tx/16Rx Coil Array for Parallel Transmit Cardiac MRI in Pigs at 7T
Ibrahim A. Elabyad1, Maxim Terekhov1, David Lohr1, Maya Bille1, and Laura M. Schreiber1

1Chair of Molecular and Cellular Imaging, Comprehensive Heart Failure Center (CHFC), University Hospital Wuerzburg, Wuerzburg, Germany

A dedicated flexible 16-element transceiver coil array was developed, simulated, and tested for cardiac MRI (cMRI) in pigs at 7T. The 16-elements of the array are printed on a flexible (Kapton polyimide) substrate to conform to the pig thorax. The performance of the elastic array is evaluated by EM-simulations and MR-measurements in a pig phantom and a 45-kg pig in-vivo. The flexible array supports parallel imaging with acceleration factors up to R=4 with reasonable g-factors (g=1.2) in an ROI at the position heart. The array enables geometrical conformity to pig body weights within a large range of sizes and shapes.

3318
Booth 9
Target specific optimization of the transmit k-space trajectory stack-of-spirals and SPINS for pTx pulse design
Ole Geldschläger1, Dario Bosch1,2, and Anke Henning1,3

1High-field Magnetic Resonance, Max-Planck-Institute for biological Cybernetics, Tübingen, Germany, 2Biomedical Magnetic Resonance, University Hospital Tübingen, Tübingen, Germany, 3Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

Four basis transmit k-space trajectories (a single variable density spiral-in, a two stack of variable density spiral-in, a three stack of variable density spiral-in and a SPINS trajectory) were optimized for pTx radiofrequency pulse design in order to match the excitation target pattern. The parameter to be optimized where the parameter of the analytical equations of the basis trajectories. The procedure was tested on local excitation and whole brain-like excitation target patterns. Optimized trajectories enabled considerably improved radiofrequency pulse performance, compared to radiofrequency pulses based on unsuited trajectories. The optimization code is available online as open source (https://github.com/ole1965/workflow_OTUP.git).

3319
Booth 10
An 8-Channel Shielded Transceiver Coil for Carotid Artery imaging at 7T
Pedram Yazdanbakhsh1, Marcus Couch2, Kyle M. Gilbert3, Johnny Derhovagimian1, and Richard Hoge1

1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada, 2Siemens Healthcare Limited, Montreal, QC, Canada, 3Centre for Functional and Metabolic Mapping, Western University, London, ON, Canada

An 8-channel shielded transmit/receive RF array has been designed and fabricated for imaging the carotid arteries at 7T. The array, similar to that presented in Ref. [1], consists of four overlapping surface loops per side. In addition to the Ref. [1], we have also added two RF shields per side with DC blocking capacitors to mitigate eddy currents. To ensure robust safety of the 7T pTx coil, local SAR matrices, and the commensurate virtual observation points (VOPs), were calculated for online SAR supervision [2,3]. Finally, the phase and amplitude of each channel have been optimized to achieve maximum B1+ homogeneity.


3320
Booth 11
Evaluating a Volumetric High-Permittivity (HPM) Helmet for Brain Imaging at 3.0 T
Karthik Lakshmanan1,2, Jezry Walczyk1,2, Sebastian Rupprecht3, Michael T Lanagan3, Qing X Yang3, Ryan Brown1,2,4, and Christopher Collins1,2,4

1Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, NYU Grossman School of Medicine, Newyork, NY, United States, 2Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, NYU Grossman School of Medicine, New york, NY, United States, 3HyQRS, LLC, State College, PA, United States, 4Vilcek Institute of Graduate Biomedical Science, NYU Grossman School of Medicine, New york, NY, United States

A thin (8mm) helmet-shaped shell of high-permittivity material (HPM) is seen to double transmit efficiency and increase SNR by 40% at the center of tissue equivalent head phantom when compared to the body coil alone, with little effect on B1 homogeneity within the brain region. While evaluation of effects on receive arrays is ongoing, from the results shown here it seems an HPM helmet could be used at 3T in place of more electronically cumbersome head transmit coils.



Safety, Low Field & Interventional I

Gather.town Space: North West
Room: 4
Monday 17:00 - 19:00
Physics & Engineering
Module : Module 8: Safety, Low-Field, and Interventional

3575
Booth 1
MRSaiFE: towards the real-time prediction of SAR in 3T and 7T MR RF coils - a feasibility study with 10 body models
Sayim Gokyar1, Isabelle Saniour1, Fraser Robb2, Arthur Nghiem3, Wolfgang Kainz4, Akshay S. Chaudhari5, and Simone Winkler1

1Radiology, Weill Cornell Medicine, New York, NY, United States, 2General Electric Healthcare, Aurora, OH, United States, 3Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States, 4Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, United States, 5Radiology, Stanford University, Stanford, CA, United States

Significant RF power deposition in the body causing local specific absorption rate (SAR) in the form of hotspots is an important safety concern at 3T (128 MHzand, even more so, at 7T (298 MHz). In this work, we expand the proof-of-concept of artificial intelligence based real-time MRI safety prediction software (MRSaiFE) to 10 body models. We show that SAR patterns can be predicted with a mean squared error (MSE) of less than 1% and structural similarity index of above 90% for 7T brain and above 85% for 3T body MRI.

3576
Booth 2
Assessment of MRF for Simultaneous T1 and T2 Quantification and Water-Fat Separation in the Liver at 0.55T
Yuchi Liu1, Jesse Hamilton1,2, Yun Jiang1,2, and Nicole Seiberlich1,2

1Department of Radiology, University of Michigan, Ann Arbor, MI, United States, 2Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States

This study aims to assess the feasibility of performing MRF in the liver and examine the feasibility of water-fat separation using rosette MRF at low field. MRF sequences using spiral and rosette trajectories were implemented on a 0.55T scanner. T1 and T2 quantification in the liver was achieved in a single breath-hold of <15s with in-plane resolution of 1.56×1.56mm2 and slice thickness of 5mm. In addition, water-fat separation was achieved along with T1 and T2 quantification with no time penalty using rosette MRF.


3577
Booth 3
RF coil modeling with mechanical components: initial investigation
Xin Chen1 and Michael Steckner1

1Canon Medical Research USA Inc, Mayfield Village, OH, United States

Electromagnetic modeling has been widely used to study MRI RF coils, but the coil model usually only consists of conductors and lumped elements. The impact of mechanical components (such as coil housing, patient table) has not yet been thoroughly investigated. This work showed that including mechanical parts in the model lead to noticeable changes of total B1 and E fields (up to 15% and 32% increase respectively in the central axial slice), peak SAR (22%), and coil input power (67%) calculations.  

3578
Booth 4
Study of B1 and SAR Field Distribution for loop coil with different bending angles at 3T
Tripta Sharma1 and Xiaoliang Zhang1

1Biomedical Engineering, University at Buffalo, Buffalo, NY, United States

The aim is to investigate the RF field behavior of flexing loop coils as resonant elements in flexible RF arrays. Numerical modeling and simulation of a mechanically flexible single channel RF coil at different bending angles for 3T MRI are implemented to determine the best bending angle that will generate highest B1 magnetic field inside imaging area with least flux cancellation at center. Results include B1 magnetic and SAR field distribution of the coronal, sagittal and transverse planes of phantom at 9 bent angles. It also includes the comparative quantitative analysis of magnetic field at different biological samples.

3579
Booth 5
Extension of Simple Safety Framework to Realistic Configurations
Jagjit Sidhu1, Pallab Bhattacharyya1, Ken Sakaie1, and Mark Lowe1

1Cleveland Clinic, Cleveland, OH, United States

Implanted electrodes in patients used to treat movement disorders can induce unsafe heating in scanners above 1.5T. However, this patient population will likely benefit strongly from having the option of high field and ultra-high field scanners. To remedy this situation, we demonstrate a proof-of-concept that by carefully selecting the weights of the B1 shim on a Siemens 3T Prisma scanner, negligible temperature rise can be obtained using a T2-TSE sequence. We also show that when no temperature rise is obtained, the image quality is better and more homogeneous.

3580
Booth 6
A small loop makes a big difference: Modifying trajectory of epicardial leads substantially reduces RF heating of CIEDs in children during 1.5T MRI
Fuchang Jiang1, Bhumi Bhusal2, Bach Nguyen2, Michael Monge3, Gregory Webster4, Daniel Kim2, Giorgio Bonmassar5, Andrada R. Popsecu6, and Laleh Golestanirad1,2

1Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, United States, 2Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 3Division of Cardiovascular-Thoracic Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States, 4Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States, 5A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, 6Division of Medical Imaging, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, United States

Infants with congenital heart defects, inherited arrhythmia syndromes, and congenital disorders of cardiac conduction often require cardiac implantable electronic devices (CIEDs). Some infants receive a CIED within hours, or even minutes, of birth. The presence of an epicardial CIED is a relative contraindication for cardiac magnetic resonance imaging (MRI) due to the risk of RF heating. We present results of phantom experiments and electromagnetic simulations showing that a simple surgical modification in the trajectory of epicardial leads can reduce RF heating more than 40-fold during MRI at 1.5 T. 

3581
Booth 7
Magnetic Susceptibility of Common Metals and Alloys Used in Medical Devices
Grant M. Baker1, Eric D. Anttila1, Erick Smith1, Andrew Robison1, and David C. Gross1

1MED Institute Inc., West Lafayette, IN, United States

The goal of this study was to characterize the magnetic susceptibility and accompanying magnetically induced force, torque, and image artifact of metals and alloys that are commonly used in medical devices. These values were reported for 46 metals and alloys, with an overall trend that magnetically induced force, torque, and image artifact increased with increasing susceptibility of a material. The results of this study can inform medical device design for the development of safer and better performing devices, especially in the growing area of MR guided procedures.

3582
Booth 8
Compact 3T brain MRI for patients with abandoned leads of cardiac implantable electronic devices
Lydia J Bardwell Speltz1,2, Yunhong Shu1, Robert E Watson1, Joshua D Trzasko1, Erin Gray1, Maria Halverson1, Joseph Arant1, John Huston III1, Thomas KF Foo3, and Matt A Bernstein1

1Department of Radiology, Mayo Clinic, Rochester, MN, United States, 2Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, United States, 3GE Global Research, Niskayuna, NY, United States

Patients with abandoned pacemaker leads require special attention during MR exams due to the risk of lead tip heating from RF energy deposition.  The electromagnetic fields on the compact 3T (C3T) scanner fall off rapidly caudal to the head, and therefore present a reduced risk of lead tip heating during brain imaging.  We compared the images from a whole-body 1.5T scanner and a high-performance C3T scanner.  The C3T images show substantial improvements in image quality and greater cortical detail.  This work establishes the feasibility of C3T brain MRI with a 32-channel receive coil for patients with abandoned leads. 

3583
Booth 9
Design of an asymmetric spiral RF coil for RF spatial encoding
Yonghyun Ha1, Kartiga Selvaganesan1, Kasey Hancock1, Gigi Galiana1, and R. Todd Constable1

1Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States

Gradients in B1 can be useful as a source of spatial encoding for low-field MRI. Here, an asymmetric spiral surface coil is introduced that generates an RF gradient around the coil. Simulations have shown that the shape of the B1 field can be controlled by adjusting the spacing between the wires. The measured B1 field of the asymmetric spiral coil shows that the RF gradient is generated near the coil as shown in the simulation results.


3584
Booth 10
Shimming a Halbach Magnet for TRASE MRI on the International Space Station
Aaron R. Purchase1, Christopher Sedlock1, Gordon E. Sarty2, Jonathan C. Sharp1, and Boguslaw Tomanek1

1Oncology, University of Alberta, Edmonton, AB, Canada, 2Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada

Astronauts experience detrimental loss to bone and muscle during long-term space flight. MRI is desired to monitor bone and muscle loss, but current portable systems remain unsuitable for the International Space Station (ISS). We built a 25 kg dipolar Halbach magnet dedicated to the transmit array spatial encoding (TRASE) method over a cylindrical region of interest (ROI), which satisfies the requirements for MRI on the ISS. Still, the natural axial gradient is not well suited to slice selection because it has a quadratic-type profile producing unwanted aliasing. We propose a technique to implement a linear axial B0 gradient for encoding.

3585
Booth 11
A Parallel-Transmit Halbach Magnet TRASE MRI System
Jonathan C. Sharp1, Aaron Purchase1, Christopher Sedlock1, and Boguslaw Tomanek1

1Oncology, University of Alberta, Edmonton, AB, Canada

We have designed and constructed a low-field TRASE RF imaging system. In TRASE k-space encoding is achieved by refocusing with RF phase gradients. The system includes a motorized rotatable magnet, twin RF power amplifiers, two geometric decoupled truncated twisted solenoid RF transmit coils (1D radial TRASE encoding), and a multi-channel transmit SDR console. The magnet is a 2.835 MHz 8-ring Halbach design. All components are custom made. An inherent axial gradient of the inhomogeneous magnet function as slice selection. The unique feature of this imaging configuration is the simplicity. Two RF channels and magnet rotation provide multi-slice projection reconstruction imaging.


New Systems & Devices II

Gather.town Space: North East
Room: 5
Tuesday 9:15 - 11:15
Physics & Engineering
Module : Module 32: New Systems & Devices

3859
Booth 1
Quantification of the impact of Gadolinium agent on amide-proton-transfer weighted MRI: an ex vivo and in vivo study
Qian Yang1, Zhou Liu1, Yin Wu2, Long Qian3, and Dehong Luo1

1National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China, 2Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 3MR Research, GE Healthcare, Beijing, China

The clinical value of Amide proton transfer (APT) imaging in brain tumors has been intensively studied and validated. However, whether and how much Gadolinium-based (Gd) agent in clinical dosage has impact on the APT-weighted signal in clinical scenarios remains controversial. Hence, this study designed an in vitro study using a phantom with a gradient dosage of Gd-based agent and then validated the result in 6 patients with brain tumors. The result revealed that APT effect was significantly influenced by Gd contrast agent both in the phantom in vitro study and in vivo study.

3860
Booth 2
Resolution phantoms for MR microimaging with 4µm≤ps≤256µm based on anisotropic tube channels (PSF + MTF) fabricated by Deep X-Ray-Lithography
Andreas Georg Berg1,2 and Martin Börner3,4

1Center for Medical Physics and Biomedical Engineering, MR-Physics, Medical University of Vienna, Vienna, Austria, 2High field MR-Center, Medical University of Vienna, Vienna, Austria, 3Karlsruhe Nano-Micro facility (KNMFi), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany, 4Institute of Microstructure Technology (IMT), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany

The most important quality control criterions in Magnetic Resonance Imaging (MRI) are represented by the contrast-to-noise-ratio (CNR) and the spatial resolution. This report presents the design, a prototype object, an exemplary MRI evaluation, qualitative results and quantitation of the spatial resolution up to microscopic scale beyond pixel-size characterization.  The phantom is manufactured using Deep X-Ray Lithography (DXRL) at the Synchrotron radiation source KARA (Karlsruhe Research Accelerator) for obtaining highly anisotropic tube type cavities for getting the Point-Spread-Function (PSF) and Modulation Transfer Function (MTF) in MR-µ-imaging ranging from d=256µm down to d≈4 µm.  

3861
Booth 3
Temperature Dependence of the Electric Properties in MR Phantoms
Umberto Zanovello1, Wolfgang Kilian2, Adriano Troia1, Bernd Ittermann2, Alessandro Arduino1, and Luca Zilberti1

1Istituto Nazionale di Ricerca Metrologica (I.N.Ri.M.), Torino, Italy, 2Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany

Phantom realization represents an important activity for the development and validation of advanced MR-based quantitative imaging techniques such as Magnetic Resonance Fingerprinting or Electrical Properties Tomography. In this regard, phantoms represent a reliable ground truth with the requirement that the sought properties are properly characterised in the variety of conditions at which the phantoms will be finally deployed. In this abstract, measurements of the electrical properties of two different gel-based tissue-mimicking materials are presented as a function of their temperature. A linear dependence with positive (negative) slope between temperature and electrical conductivity (relative permittivity) is observed.

3862
Booth 4
Quantitatively Evaluating the Effect of Fat on ADC Measurement in EP-DWI and PROPELLER-DWI Using Fat-Water Phantom
Jo-Hua Peng1, Chun-Jung Juan1,2,3, Yi-Jui Liu4, Ruey-Hwang Chou5, Hing-Chiu Chang6, Chang-Hsien Liou2,7, Szu-Hsien Chou1,2, Yen-Ting Wu1,2, Bai-Wen Wu2, and Hsu-Hsia Peng1

1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Department of Medical Imaging, China Medical University Hsinchu Hospital, Hsinchu, Taiwan, 3Department of Radiology, School of Medicine, China Medical University, Taichung, Taiwan, 4Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, 5Institute of Cancer Biology, China Medical University, Taichung, Taiwan, 6Department of Biomedical Engineering, Chinese University of Hong Kong, Sha Tin, Hong Kong, 7Institute of Nuclear Engineering and Science, National Tsing Hua University, Hsinchu, Taiwan

ADC estimations are still known to be influenced by the content of fat. Fat suppression is normally applied in order to avoid the ADC measurement with fat contamination. The aim of this study was to evaluate the fat effect on ADC measurement by EP-DWI and PROP-DWI combined with different fat suppression techniques using a fat-water phantom with different fat fractions. Our results suggest that the ADC measurement is affected by the fat fraction and the MR sequences but not the fat suppression methods in EP-DWI.

3863
Booth 5
An Innovative MRI phantom Allowing Evaluation of the Influence of Fat Fraction on the Measurement of ADC under Different Glass Bead Densities
Jo-Hua Peng1, Chun-Jung Juan1,2,3, Yi-Jui Liu4, Ruey-Hwang Chou5, Hing-Chiu Chang6, Chang-Hsien Liou2,7, Szu-Hsien Chou1,2, Yen-Ting Wu1,2, Bai-Wen Wu2, and Hsu-Hsia Peng1

1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Department of Medical Imaging, China Medical University Hsinchu Hospital, Hsinchu, Taiwan, 3Department of Radiology, School of Medicine, China Medical University, Taichung, Taiwan, 4Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, 5Institute of Cancer Biology, China Medical University, Taichung, Taiwan, 6Department of Biomedical Engineering, Chinese University of Hong Kong, Sha Tin, Hong Kong, 7Institute of Nuclear Engineering and Science, National Tsing Hua University, Hsinchu, Taiwan

Although a single-function phantom for either ADC or fat content is popular, it is crucial to develop a multiple-function phantom to simulate the real situation of human tissue in vivo. The aim of our study was to design a novel phantom containing different fat fractions and cellularity to evaluate the effect of fat content on ADC measurement in vivo as in human tissue environment. In conclusion, the influence of fat contents and glass beads density on ADC values was examined in our dual-function phantom, which can be helpful to improve the accuracy of ADC quantification in clinical practice.

3864
Booth 6
Deep Learning Driven EMI Prediction and Elimination for RF Shielding-Free MRI at 0.055T and 1.5T
Yujiao Zhao1,2, Linfang Xiao1,2, Yilong Liu1,2, Alex T. L. Leong1,2, and Ed X. Wu1,2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China

All clinical MRI scanners require bulky and enclosed RF shielding rooms to prevent external electromagnetic interference (EMI) signals during data acquisition, and quality electronics inside shielding room (i.e., with minimal EMI emission). A deep learning EMI cancellation strategy is presented to model, predict and remove EMI signals from acquired MRI signals, eliminating the need for RF shielding. We demonstrated that this method worked robustly for various EMI sources from both external environments and internal scanner electronics, producing final image SNRs highly comparable to those obtained using a fully enclosed RF shielding cage in 0.055T and 1.5T experiments.

3865
Booth 7
Design of a Metamaterial-inspired Flexible Structure for MRI Field Enhancement at 3T: a Numerical Approach
Morteza Teymoori1 and Arda Deniz Yalçınkaya2

1Institute of Biomedical Engineering, Boğaziçi University, Istanbul, Turkey, 2Department of Electric and Electronics Engineering, Boğaziçi University, Istanbul, Turkey

MR imaging has a significant role in medical diagnostics. Imaging quality depends on SNR levels. Higher B0 field and consequently higher RF-field intensity increase SNR but it also elevates the total body SAR. This can be alleviated by local magnetic field enhancement. Metamaterial based structures have shown promising applications in this regard. Here we report a new metamaterial inspired resonant structure for local field enhancement in 3T MRI machine. We show field enhancement capabilities of our design in planar and cylindrical forms, each of which can be used based on the anatomical site under investigation. 


3866
Booth 8
Miniaturized and Reproducible Phase Shifters using Capacitor-Loaded Transmission Lines for Add-On RF Shimming at High Field
Ming Lu1, Yue Zhu2,3, John Gore2,3,4, William A. Grissom2,3,4, and Xinqiang Yan2,3

1College of nuclear equipment and nuclear engineering, Yantai University, Yantai, China, 2Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 3Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 4Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

Add-on RF shimming devices, including phase shifters, could provide additional degrees of freedom for RF transmit chains to improve field uniformity and reduce SAR. At the Larmor frequencies of MRI, however, the transmission line length for realizing large phase shifts becomes unrealistically long. We introduce a capacitor-loaded transmission line design to build a miniaturized microstrip line phase shifter for RF shimming at high fields. The fabricated phase shift boards had a miniaturized size of 3 x 4 cm2, exhibited a low loss of < 0.26 dB, and cost much less than those made from other materials. 

3867
Booth 9
A Balanced RF Switch for Ultra-Wideband System with Microsecond Dead Time
JunCheng Xu1, Shouquan Yao1, Ming Shen1, Yiqiao Song2,3, Yu Jiang1, and Jianqi Li1

1Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, shanghai, China, 2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 3John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, United States

This work demonstrated a fully balanced strcture of wideband RF switch. The switch utilizes PIN diodes to form two balanced paths which transmit the RF signals in common mode and the drive signal of PIN diode in differential mode.The common-mode choke can be used to block AC signal and feed DC bias. It can also be used to suppress the transient voltage due to the drive signal. The switch achieved low insertion loss and high isolation within a bandwidth between 10MHz-100MHz. The switch also suppressed the transient voltage to less than 3.3mV with a very short dead time.   

3868
Booth 10
Wireless power transfer on non-main eigenmodes within birdcage coil
Oleg I. Burmistrov1, Egor I. Kretov1, Dmitrii S. Dashkevich1, and Pavel S. Seregin1

1School of Physics and Engineering, ITMO university, Saint-Petersburg, Russian Federation

In this work, we investigate a concept of a wireless power transfer system for 1.5T MRI scanner. Our system exploits additional eigenmodes of a birdcage body coil that are not used during the scanning process. Such a solution could be implemented in existing hardware with a minor change in MRI components and at the same time minimize the interference between the power transfer system and imaging functions of the scanner.

3869
Booth 11
Intravoxel incoherent motion imaging of a small-vessel MRI phantom: Preliminary study.
Hajime Tamura1, Hideki Ota2, Tatsuo Nagasaka3, Ryuichi Mori3, Yuki Ichinoseki3, and Kenichi Funamoto4

1Department of Medical Physics, Tohoku University, Graduate school of medicine, Sendai, Japan, 2Department of Advanced MRI Collaborative Research, Tohoku University, Graduate school of medicine, Sendai, Japan, 3Department of Radiology, Tohoku University hospital, Sendai, Japan, 4Institute of Fluid Science, Tohoku University, Sendai, Japan

IVIM signal intensities could be compared with the ‘ground truth’ by use of a micro-vessel phantom in this study. In IVIM imaging, images with b = 0 are often included in the analysis, but this study indicated that  images with b = 0 should be excluded. In this study, IVIM analysis showed a tendency to overestimate D* and underestimate f.

3870
Booth 12
Analytical B0 shimming from 3D survey scans: feasibility and impact on EPI image quality
Sharun S Thazhackal1, Ashvin Srinivasan1, Suja Saraswathy1, Manivannan Jayapalan2, Umesh Rudrapatna2, and Jaladhar Neelavalli2

1Philips Research, Bangalore, India, 2Philips Healthcare, Bangalore, India

The inhomogeneity in the main magnetic field (B0) leads to SNR loss and image artifacts. B0 inhomogeneity increases with the field strength, thus leading to more pronounced B0 inhomogeneity at 3T and beyond. However repeated B0 map acquisition for shimming and for image reconstruction is time consuming. We show that subject-specific B0 and the corresponding shim settings can be predicted accurately using pseudo-CT generated from MR images – potentially obviating the need for a B0 scan. We propose an alternative approach based on image co-registration techniques that yields comparable results using survey images, without the need of any additional scans. 

3871
Booth 13
Diagnostic Ultra-low-dose 18F-PI-2620 Tau PET/MRI with Generative Adversarial Network-based Enhancement
Kevin T Chen1,2, Robel Tesfay3, Mary Ellen I Koran2, Jiahong Ouyang2, Sara Shams2, Tie Liang2, Mehdi Khalighi2, Elizabeth Mormino2, and Greg Zaharchuk2

1National Taiwan University, Taipei, Taiwan, 2Stanford University, Stanford, CA, United States, 3Meharry Medical College, Nashville, TN, United States

With the focal and lower uptake in tau PET imaging compared to other tracers such as amyloid, we aim to use multimodal simultaneous PET/MR imaging combined with training a generative adversarial network (GAN) to enhance ultra-low-dose 18F-PI-2620 tau PET images. We showed that the deep learning-enhanced images greatly reduced image noise as compared to the ultra-low-dose images, outperformed the ultra-low-dose images metrics-wise, and were able to be read clinically for regional uptake patterns of tau accumulation similarly as the full-dose images.

3872
Booth 14
High-Resolution 3D-TOF MR Angiography in intracranial arteries and branches: A Initial Experience on Comparison between 3.0-T and 5.0-T
Zhang Shi1, Jiang Lin1, Yunfei Zhang2, Yongming Dai2, and Mengsu Zeng1

1Zhongshan Hospital of Fudan University, Shanghai, China, 2Central Research Institute, United Imaging Healthcare, Shanghai, China

3D-Time-of-Flight MR Angiography (3D TOF-MRA) of the intracranial vessels is a first-line and noninvasive tool for the evaluation of patients with cerebrovascular disease. However, it is still challenged at 3.0-T MR imaging because peripheral segments of the main arteries can often not be sufficiently visualized. The expected remarkable increase in visualizations of intracranial arteries segments and vessel brancher provided by ultra-high field 5.0-T MRI may be valuable for addressing above issues. Our prospective analysis demonstrated that the 5.0-T TOF-MRA provides higher improvement in visualization of distal large arteries and small vessel branches than that at 3.0-T.


New Systems & Devices III

Gather.town Space: North East
Room: 4
Tuesday 14:30 - 16:30
Physics & Engineering
Module : Module 32: New Systems & Devices

3947
Booth 1
Characterization and Correction of Diffusion Gradient-Induced Eddy Currents in Echo-Planar and Spiral Cardiac Diffusion Tensor Imaging
Robbert J.H. van Gorkum1, Christian Guenthner1, Andreas Koethe1,2, Christian T. Stoeck1,3, and Sebastian Kozerke1

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2Center for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland, 3Division of Surgical Research, University Hospital Zurich, University Zurich, Zurich, Switzerland

Second-order motion-compensated diffusion encoding gradient waveforms cause substantial eddy currents (ECs), which can violate the linear-system assumption of a gradient impulse response function and thus require a dedicated measurement and reconstruction approach. Using a 3-dimensional spectroscopic imaging method, diffusion encoding gradient-induced ECs were characterized and non-linear effects were identified. When accounting for zeroth- and first-order diffusion encoding gradient-induced ECs besides off-resonance and trajectory-induced concomitant fields and ECs, image distortions could be adequately mitigated in echo-planar and spiral in vivo second-order motion-compensated cardiac diffusion tensor imaging sequences.

3948
Booth 2
Simulation of a shield effect on a J-pole antenna array for ultra-high field MR-PET
Chang-Hoon Choi1, Suk-Min Hong1, Jörg Felder1,2, Christoph Lerche1, and N. Jon Shah1,3,4,5

1Institute of Neuroscience and Medicine - 4, Forschungszentrum Juelich, Juelich, Germany, 2RWTH Aachen University, Aachen, Germany, 3Institute of Neuroscience and Medicine - 11, Forschungszentrum Juelich, Juelich, Germany, 4JARA - BRAIN - Translational Medicine, Aachen, Germany, 5Department of Neurology, RWTH Aachen University, Aachen, Germany

Interest in simultaneously operating MR-PET systems as a means of accessing multiple biological parameters with high spatial and temporal resolution is increasing.  In a hybrid acquisition, the RF antenna is used inside the PET FOV generating potential photon loss and artefacts. A multi-channel J-pole antenna array, which does not include any high-density parts in the imaging FOV, has been recently introduced, and its outstanding performance has been demonstrated. To prevent interference between MR and PET, including an RF shield is necessary. Here, we conducted a simulation to compare the characteristics of the J-shape antenna array with and without the shield.  

3949
Booth 3
iMPI – first real-time imaging with a human-sized interventional Magnetic Particle Imaging scanner
Patrick Vogel1, Martin A Rückert1, Teresa Reichl1, Johanna Günther1, Christoph Greiner1, Liana Mirzojan1, Alexander von Böhn1, Thomas Kampf2, Thorsten A. Bley3, Volker C. Behr1, and Stefan Herz3

1Experimental Physics 5 (Biophysics), University of Würzburg, Würzburg, Germany, 2Diagnostic and Interventional Neuroradiology, University Hospital Würzburg, Würzburg, Germany, 3Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany

In this work a first human-sized Magnetic Particle Imaging (MPI) scanner designed and specifically engineered for experimental (cardio)vascular interventions is presented.

Based on a novel open design implementing the so called traveling wave MPI approach, the open iMPI system provides imaging of Tracers based on superparamagnetic iron oxide nanoparticles (SPIONs) with high sensitivity, optimal patient handling and would even allow hybrid imaging of magnetic tracers within gold standard x-ray based interventional angiography systems.

In initial experiments, the feasibility of a human-sized interventional MPI scanner with real-time data reconstruction and image visualization is demonstrated.


3950
Booth 4
8ch multi transmit with ultrasonic dual axis gradient and 32ch receive setup for fast spatial encoding at 7T
Mark Gosselink1, Aris van Ieperen1, Wout Schuth2, Martino Borgo2, Dimitri Welting1, Edwin Versteeg1, and Dennis Klomp1

1Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Futura composites, Heerhugowaard, Netherlands

We propose a setup to boost spatiotemporal encoding for MRI in the human brain using a conventional receiver array (32ch) and fast gradients (6100T/m/s). Moreover, we demonstrate that the operation frequency of a high-end gradient-amplifier can be increased to ultrasonic frequencies so to avoid unpleasant acoustic noise. By using this amplifier with 8 RF transmitters, 32 receivers and a 2-channel gradient coil, a light-weight setup is constructed for operation in a 7 Tesla MRI system. The setup is demonstrated for operation in the human brain showing good FLAIR data and no peripheral nerve stimulation at the slew rate of 6100T/m/s.

3951
Booth 5
Optimized variable winding pitch coil designs for miniature B0 field modification.
Niklas Wehkamp1, Philipp Rovedo2, and Maxim Zaitsev3

1Department of Radiology, Medical Physics, Medical Center – University of Freiburg, Freiburg, Germany, 2Neurozentrum, Medical Center – University of Freiburg, Freiburg, Germany, 3High Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria

We present numerical optimization of variable winding pitch coil designs for miniature coils with respect to target field homogeneity. The optimization is based on a continuous coil winding layout that was used to simulate field homogeneity in the target volume via the Biot-Savart law. The example coil designs expand the range of applications for frequency adjustable field probes, as they increase the B0 modification field’s homogeneity by factor of 7. Due to the specific requirements of miniature B0 modification coils, the dimensions of the coil are restricted in length, width and wire diameter.


3952
Booth 6
Measuring stroke volume with wearable RF antennas: a validation study with EM simulations and MRI
Bart Romke Steensma1, Christina Anna Louka1,2, Alexander Jurriaan Eberhardt Raaijmakers3, and Cornelis Antonius Theodorus van den Berg1

1Center for Image Sciences, Computational Imaging Group, University Medical Center Utrecht, Utrecht, Netherlands, 2School of Applied Mathematical and Physical Sciences, Department of Physics, National Technical University of Athens, Athens, Greece, 3Biomedical Engineering, Medical Imaging Analysis, Eindhoven University of Technology, Eindhoven, Netherlands

We developed a wearable setup to detect heart motion and stroke volume with an RF antenna connected to a miniature network analyzer. EM simulations were used to demonstrate the possibility of measuring changes in stroke volume with an RF antenna and to investigate the spatial sensitivity of the antenna. A Valsalva manoeuver was used to provoke changes in stroke volume, which were observed with the RF antenna and in cine MRI acquisitions.

3953
Booth 7
Wireless Physiological Motion Monitoring with an Integrated RF/Wireless Coil Array and MR-Compatible Ultrasound-Based System
Devin Willey1,2, Olivia Jo Dickinson1,2, Devon Karl Overson1,2, Trong-Kha Truong1,2, Fraser Robb3, Allen W Song1,2, Bruno Madore4, and Dean Darnell1,2

1Brain Imaging And Analysis Center, Duke University, Durham, NC, United States, 2Medical Physics Graduate Program, Duke University, Durham, NC, United States, 3Brain Imaging And Analysis Center, GE Healthcare, Aurora, OH, United States, 4Radiology, Brigham and Women's, Harvard Medical School, Boston, MA, United States

A wireless MR-compatible ultrasound-based device consisting of an integrated RF/wireless coil, organ-configuration motion sensor, Raspberry Pi, pulser/receiver, and analog-to-digital converters was developed to acquire, digitize, and wirelessly transmit ultrasound data while simultaneously acquiring MR-images. Experiments were performed to demonstrate the system's 1)  mobility through continuously acquiring, digitizing, and wirelessly transmitting ultrasound data at multiple locations, and 2) ability to wirelessly monitor physiological motion during coughing/gasping. This integrated system enables the OCM sensor to travel with patients throughout the hospital while also demonstrating the ability of the iRFW coil and backend electronics to process and wirelessly transmit a high-fidelity signal.


RF Coils, Technologies & Sequences III

Gather.town Space: North East
Room: 6
Tuesday 16:45 - 18:45
Physics & Engineering
Module : Module 24: RF Coils, Technologies & Sequences

4101
Booth 1
Improved TSE imaging at Ultra-High Field using Non-localized Efficiency Shimming and Acquisition of Modes Optimized for Refocused Echo (AMORE)
Xiaoxuan He1, Simon Schmidt1, Stefan Zbyn1, Tobey Haluptzok1, Steen Moeller1, and Gregory J. Metzger1

1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

To mitigate B1+ inhomogeneity at ultra-high field (UHF), we propose a novel non-localized efficiency shim and utilize this to optimize for T2W TSE contrast in a technique termed Acquisitions of Modes Optimized for Refocused Echo (AMORE). A non-localized efficiency shim is ideal for turbo spin echo (TSE) or fast spin echo (FSE) imaging of smaller anatomical targets such as brain and knee, while AMORE is an optimized TIAMO for improved TSE imaging in the torso by ensuring the desired B1+ is achieved. With AMORE two phase-only modes appear sufficient to mitigate the B1+ shadings and nulls in the interior torso.

4102
Booth 2
Fabrication Methods for Stretchable, Self-tuning Multi-element Liquid Metal Coil Arrays (LiquiTune)
Elizaveta Motovilova1,2, Terry Ching3,4, Jana Vincent5, James Shin1, Ek Tsoon Tan2, Victor Taracila5, Fraser Robb5, Michinao Hashimoto3, Darryl Sneag2, and Simone Angela Winkler1

1Department of Radiology, Weill Cornell Medicine, New York, NY, United States, 2Department of Radiology and Imaging, Hospital for Special Surgery, New York, NY, United States, 3Pillar of Engineering Product Development, Singapore University of Technology and Design, Singapore, Singapore, 4Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore, 5GE Healthcare, Aurora, OH, United States

We recently proposed a self-tuning stretchable receive coil concept in a single element. Here, we expand the technique to a multi-element array and compare 3 fabrication techniques: 1) single layer, 2) double layer, 3) direct ink writing (DIW). Numerical simulations are used to find the critical overlap for decoupling. In vitro experiments demonstrate almost identical sensitivity between the 3 techniques and between coil elements. DIW is most suitable due to its mechanical stability and thinner/less MR-visible coil elements with a frequency stability of 128+/-0.6 MHz (0 to 30% of stretch) and an SNR improvement of 50% over a commercial coil.

4103
Booth 3
A Dielectric Material Coated Half-Wave Dipole antenna for Ultrahigh Field MRI at 7T/300MHz
Aditya Ashok Bhosale1, Divya Gawande1, and Xiaoliang Zhang1

1Biomedical Engineering, University at Buffalo, Buffalo, NY, United States

The potential of half-wave dipole antennas in MRI is primarily recognized. This study presents the dielectric material-coated half-wave dipole antenna design and compares it with the conventional half-wave dipole antenna. The design includes a high dielectric material coating around the length of each conductor. The dipole length primarily determines the resonant frequency of a dipole antenna; therefore, it is difficult to tune small half-wave dipole antennas less than 50 cm at 300MHz. Our design provides a solution to this problem and can tune smaller half-wave dipole antennas at 300MHz without meandering the dipole conductors. 


4104
Booth 4
B1 field flattening and length control of half-wave dipole antenna with discrete dielectric coating
Aditya Ashok Bhosale1, Divya Gawande1, and Xiaoliang Zhang1

1Biomedical Engineering, University at Buffalo, Buffalo, NY, United States

This study presents a method for the B1 field flattening and length control of the half-wave dipole antenna for MR imaging with discrete dielectric material coating. To demonstrate this method, we designed a half-wave dipole antenna to operate at 300MHz, including coating the ends of the dipole conductors with a high dielectric material, serving as a way to control the dipole length and electromagnetic field distribution. We also compare the proposed technique with the conventional half-wave dipole antenna and show how the new technique effectively tunes the shorter half-wave dipole antennas at specific frequencies and produces efficient field distributions.


4105
Booth 5
An 8-Channel High-permittivity Dielectric Material-Coated Half-Wave Dipole Antenna Array for Knee Imaging at 7T
Aditya Ashok Bhosale1, Leslie L Ying1, and Xiaoliang Zhang1

1Biomedical Engineering, University at Buffalo, Buffalo, NY, United States

Magnetic resonance imaging for Musculoskeletal imaging plays a vital role in the early detection of various abnormalities. New array systems designed explicitly for Musculoskeletal imaging at Ultra-high field strengths are being developed rapidly. In this study, we propose a new 8-channel array system consisting of High-permittivity dielectric material-coated half-wave dipole antennas for knee imaging at Ultra-high field 7 Tesla. 


4106
Booth 6
Rendering MRI Coils Less Visible in MR images
Elizaveta Motovilova1,2, Frida Maria Galaviz Huerta3, Jana Vincent4, James Shin1, Ek Tsoon Tan2, Fraser Robb4, Victor Taracila4, Darryl Sneag2, and Simone Angela Winkler1

1Department of Radiology, Weill Cornell Medicine, New York, NY, United States, 2Department of Radiology and Imaging, Hospital for Special Surgery, New York, NY, United States, 3Department of Psychology, New York University, New York, NY, United States, 4GE Healthcare, Aurora, OH, United States

It is commonly undesirable to see an RF coil in MR images. Novel research into innovative coil designs often involves the use of new materials that can be visible in MR images. In this abstract, we address this limitation by doping the coil substrate with Magnevist, drawing from a little-known phenomenon of signal hypointensity via T2-shortening for large concentrations of gadolinium-based (Gd) contrast agents that is especially applicable to hydrogen-rich materials. We show successful reduction of MR signal of >60% using our previously developed stretchable, liquid-metal based Ecoflex coil (6) using relaxometry measurements and in vitro experiments.

4107
Booth 7
A 24-channel vacuum formed pediatric pTx knee coil for 7T
Matt Waks1, Karthik Gopalan2, Stefan Zbyn1, Lance DelaBarre1, Abdul Wahed Kajabi1, Julian Maravilla2, Gregor Adriany1, Michael (Miki) Lustig2, Ana Claudia Arias2, and Jutta Ellermann1

1University of Minnesota, Minneapolis, MN, United States, 2UC Berkely, Berkeley, CA, United States

A pediatric focused 24-channel prototype pTx 7T knee coil consisting of an 8 channel stripline transceiver and a 16-channel close fitting receiver array is described. Initial comparison with an adult size knee coil indicates peripheral SNR gains and more modest - yet notable- gains for central SNR due to the favorable filling factor and form fitting receivers of the pediatric knee coil prototype.

4108
Booth 8
A High RF Bandwidth Diffusion Preparation for Diffusion Weighted Imaging Near Metallic Implants
Philip Kenneth Lee1,2, Daehyun Yoon2, Jesse Kerr Sandberg2, Shreyas Vasanawala2, and Brian Andrew Hargreaves1,2,3

1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States, 3Bioengineering, Stanford University, Stanford, CA, United States

There is no widely adopted clinical protocol for diffusion weighted imaging near metal since the commonly used EPI trajectory fails completely due to distortion from off-resonance. We combine the magnetization prepared, stimulated echo diffusion preparation with 3D MSI encoding to enable volumetric diffusion weighted imaging near metal in clinically feasible times. Imaging time is reduced by a factor of 2× with high RF bandwidth root-flipped Shinnar-Le Roux refocusing pulses since spectral coverage can be maintained with fewer excitations. Joint design of the excitation and refocusing pulses reduces B1 sensitivity.


4109
Booth 9
A 16-channel splittable non-overlapped self-decoupled loop transmitter for 10.5 Tesla human head imaging
Matt Waks1, Nader Tavaf1, Russell Lagore1, Steve Jungst1, Jerahmie Radder1, Andrea Grant1, Lance DelaBarre1, Pierre-Francois Van de Moortele1, Gregor Adriany1, and Kamil Ugurbil1

1University of Minnesota, Minneapolis, MN, United States

A 16-channel dual row loop transmitter utilizing self-decoupling principles has been designed and prototyped for human head imaging at 10.5 Tesla. The coil employs an intentional asymmetry of impedances within each coil element in order to reduce the interaction between coil elements. Electromagnetic simulations provide an estimate for achievable decoupling and the expected loop current distribution with both a phantom load and a human head model. Bench measurements confirmed the simulation results and indicated coil to coil decoupling on the order of -10 dB or better. MR experimental results indicated minimal interaction with our 63 channel receiver array.

4110
Booth 10
A 24-channel Array for Awake NHP Imaging at 10.5 Tesla
Steve Jungst1, Russell Lagore1, Matt Waks1, Jan Zimmermann2, and Gregor Adriany1

1Radiology, University of Minnesota, Minneapolis, MN, United States, 2Neuroscience, University of Minnesota, Minneapolis, MN, United States

A 24-channel receiver – dual channel transmitter array for awake monkey imaging at 10.5 Tesla is presented. This was achieved by adding an 8-channel extension to a previously built 16-channel receive array. The new layout does not require any user adjustments and fully supports monkey imaging.

4111
Booth 11
7 Tesla 16-channel transceiver loop array for simultaneous head and cervical spinal cord imaging
Bei Zhang1, Daniel Lowrance1,2, Ole Geldschläger3, and Anke Henning1,3

1Advanced Imaging Research Center, UTSouthwestern Medical Center, Dallas, TX, United States, 2Graduate school, University of Texas Dallas, Richardson, TX, United States, 3Max Planck Institute for Biological Cybernetics, Tuebingen, Germany

Simultaneous assessment of the brain and the cervical spinal cord is of great importance in clinical decision making in areas such as head & neck cancer, traumatic injury, multiple sclerosis or stroke. The small diameter of the cervical spinal cord necessitates high spatial resolution, so there is a growing need to provide 7T simultaneous head and cervical spinal cord imaging, to greatly benefit from increased signal-to-noise ratio and contrast at ultrahigh field. In this work, we developed a 7T 16ch transceiver array that is capable for simultaneous and high-resolution brain and cervical spinal cord imaging.

4112
Booth 12
B1+ efficiency of a single-loop dual-frequency surface coil for proton and deuterium or oxygen-17 magnetic resonance imaging at 16.4T
Guangle Zhang1, Wei Zhu1, Xin Li1, Tao Wang1, Xiao-Hong Zhu1, and Wei Chen1

1University of Minnesota, Minneapolis, MN, United States

We compared the B1 efficiency of a newly developed dual-frequency surface coil operating at proton and low-g X-nuclei frequencies at 16.4T with that of traditional proton coil and X-nuclei coil, respectively. Both simulation and experimental results revealed that the B1 field strength of the new coil was similar to that of traditional coil at deuterium or oxygen-17 frequency though was significantly reduced at proton frequency, while their B1 distributions were identical for both proton and deuterium/oxygen-17 frequencies. The efficacy of the new coil for in-vivo deuterium metabolic imaging applications was demonstrated in normal and tumor rat brains. 


4113
Booth 13
A 15-channel End-coated Half-wave Dipole Antenna Array System for Foot/Ankle/Calf Imaging at 7T
Aditya Ashok Bhosale1, Leslie L Ying1, and Xiaoliang Zhang1

1Biomedical Engineering, University at Buffalo, Buffalo, NY, United States

This study proposes a new 15-channel end-coated half-wave dipole antenna array system for foot/ankle/calf imaging at 7T. The ends of the dipole antennas, operating at 300MHz, are coated with a high-permittivity dielectric material to decrease their length and flatten the B1 field simultaneously. The end-coated dipole antennas are placed around the region of interest to gain the required B1 coverage in the imaging target.  


4114
Booth 14
Comparison of 64-channel and 32-channel head arrays at 7T and 10.5T in full-wave simulation
Bei Zhang1, Jerahmie Radder2, Andrea Grant2, Russell Lagore2, Matt Waks2, Nader Tavaf2, Pierre-francois Van De Moortele2, Gregor Adriany2, Riccardo Lattanzi3, and Kamil Ugurbil2

1Advanced Imaging Research Center, UTSouthwestern Medical Center, Dallas, TX, United States, 2Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, United States, 3Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States

Idealized analytical electromagnetic (EM) models predict a spatially non-uniform signal-to-noise-ratio (SNR) gain with increasing coil elements and magnetic field strength. Using realistic EM models, we calculated the performance of prototype 32- and 64-channel receive head arrays at 7T and 10.5T using full-wave simulation with a head-mimicking gel phantom. We obtained SNR and g-factor results in agreement with predictions from ultimate intrinsic calculations, showing ~2-fold SNR gains for a large central region for 64 channels at 10.5T vs. 7T, and lower g-factors with the higher field and higher channel counts; peripheral SNR depended on both field magnitude and channel count.

4115
Booth 15
Characterizing the relative performance of a 13C/31P surface coil for simultaneously studying metabolism and energetics
Manushka Vaidya1, Bei Zhang2, DongHyun Hong1, Ryan Brown3, Georgios Batsios1, Pavithra Viswanath1, Jan Paska3, Gerburg Wulf4, Aaron Grant5, Sabrina Ronen1, and Peder Larson1

1Department of Radiology, UCSF, San Francisco, CA, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3Center for Advanced Imaging Innovation and Research, and Center for Biomedical Imaging, Department of Radiology, New York Univerisity School of Medicine, New York City, NY, United States, 4Department of Hematology-Oncology, Beth Israel Deaconess Medical Center, Boston, MA, United States, 5Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States

We evaluated the performance of a 13C/31P surface coil designed to detect metabolism and energetics data in the same scan session. Individually tuned coils were constructed to compare the performance of both channels of the multinuclear coil. Performance metrics such as Q ratio, SNR, flip angle maps, and transmit efficiency were measured. Our results demonstrate a decrease in performance of the 13C channel of the multinuclear coil. Removing the LCC trap circuit, used to decouple the channels, improved the Q ratio and SNR efficiency of the 13C channel. For future work, designs without a LCC trap circuit should be considered.


Safety, Low Field & Interventional II

Gather.town Space: North East
Room: 6
Wednesday 9:15 - 11:15
Physics & Engineering
Module : Module 8: Safety, Low-Field, and Interventional

4367
Booth 1
A Simulator, “MagTetris”, for Fast Calculation of Magnetic Field and Force for Permanent Magnets
Tingou Liang1, Tie Qiu1, and Shaoying Huang1

1Singapore University of Technology and Design, Singapore, Singapore

We propose a magnet simulator (named “MagTetris”) for fast calculation of both magnetic field and magnetic force generated by multiple cuboid magnets in arbitrary configurations. The accuracy of “MagTetris” is examined by comparing the calculated results to the FEM-based simulations and the experimental results through a 2-magnet experiment. The average differences between the FEM-based simulations and the “MagTetris” calculations are within 6% for field and 2% for force, while those between the measurements and the “MagTetris” are within 10% for field and 4.5% for force. For the calculation speed, “MagTetris” is 123 times faster compared to the FEM-based commercial software.

4368
Booth 2
RF Coil design for improving human liver fat quantification in a portable single-side MR system
Shiwei Yang1, Xiao Chen2, Shuen Chen1, Hai Luo2, Yue Zhao2, Ziyue Wu2, and Zhiyong Zhang1

1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, Shanghai, China, 2Wuxi Marvel Stone Healthcare Co. Ltd., Wuxi, Jiangsu, China, Wuxi, China

Earlier diagnosis of non-alcoholic fatty liver disease (NAFLD) becomes important to prevent the disease progression. Recently, a low-cost portable MR system was developed as a point-of-care screening tool for in vivo liver fat quantification. However, the subcutaneous fat may confound the live fat quantification, particularly in the NAFLD susceptible population. In this work, we propose a novel RF coil design composed of a main target coil sandwiching a set of “saturation” coil to improve human liver fat quantification. We demonstrate the capability and effectiveness of the novel RF design in phantom experiments as well as in-vivo liver scans.

4369
Booth 3
Simulation of RF heating for patients with metallic gamma knife stereotaxic headframe in MRI
Weiman Jiang1, Fan Yang1, and Kun Wang1

1GE Healthcare, Beijing, China

In this study, electromagnetic simulation was used to calculate RF heating for the patients with metallic gamma knife stereotaxic headframe in MRI. The relationship between headframe structure parameters and patient SAR was investigated. Two effective SAR derating methods of adjusting the headframe structure parameters were proposed, which can significantly decrease 10 g local SAR from 253 W/kg to 68 W/kg and head SAR from 4.2 W/kg to 2.0 W/kg. This study provides the efficient and reliable methods to ensure safety of the patients with metallic gamma knife headframe in MRI.

4370
Booth 4
A Feasibility Study of 0.055T MRI for Neuroimaging and Comparison with Clinical 3T MRI
Alex T. L. Leong1,2, Yilong Liu1,2, Yujiao Zhao1,2, Linfang Xiao1,2, Henry K. F. Mak3, Tsang Anderson4, Gary K. K. Lau5, Gilberto K. K. Leung4, and Ed X. Wu1,2,6

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China, 3Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, 4Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, 5Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, 6School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China

Magnetic resonance imaging is a key diagnostic tool in modern healthcare, yet its accessibility is low with the vast majority of clinical MRI scanners being placed in highly specialized radiology departments, large centralized imaging centers, and housed on ground floors of hospitals and clinics. In this study, we deployed our recently developed 0.055T brain ultra-low-field MRI scanner to demonstrate preliminary feasibility in diagnosing tumor and stroke cases with direct comparisons to 3T clinical MRI results. The development of such ULF MRI technologies will enable patient-centric and site-agnostic MRI scanners to fulfill the unmet clinical needs across various global healthcare sites.

4371
Booth 5
A Shielding-free Ultra-low-field 0.055T Brain MRI Scanner for Accessible Healthcare
Ed X. Wu1,2,3, Yilong Liu1,2, Alex T. L. Leong1,2, Yujiao Zhao1,2, Linfang Xiao1,2, Henry K. F. Mak4, Tsang Anderson5, Gary K. K. Lau6, and Gilberto K. K. Leung5

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China, 3School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, 4Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, 5Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, 6Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China

In this study, we describe an ultra-low-field brain MRI scanner that operates using a standard AC power outlet and is low cost to build. Using a permanent 0.055 Tesla Samarium-cobalt magnet and deep learning for cancellation of electromagnetic interference, it requires neither magnetic nor radiofrequency shielding cages. We also successfully implement four standard clinical neuroimaging protocols (T1W, T2W, FLAIR like, and DWI) and demonstrate human brain imaging on this system. This proof-of-concept work will advance the development of a new class of MRI technologies to democratize MRI for low and middle income countries and increase MRI accessibility in healthcare.

4372
Booth 6
Exposure of infants in baby gradient coils
Fangfang Tang1, Luca Giaccone2, Fabio Freschi1,2, Stuart Crozier1, and Feng Liu1

1School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia, 2Department of Energy, Politecnico di Torino, Torino, Italy

In pediatric magnetic resonance imaging, infants are exposed to rapid, time-varying gradient magnetic fields, leading to electric fields induced in the body of infants and potential safety risks (e.g., peripheral nerve stimulation). In this work, the induced electric fields by the small x, y, z gradient coils in an infant model were numerically evaluated at different model positions. It was found that the induced electric fields in most tissues exceeded the basic restrictions of the ICNIRP 2010 guidelines. 
 

4373
Booth 7
Preliminary Study of the Uncertainty for RF-induced Heating Assessment of Subcutaneous and Partially Implanted Devices during MRI Exposure
Aiping Yao1, Minjuan Ma1, Yunfeng Pei1, and Longjun Tang2

1Lanzhou University, Lanzhou, China, 2Shanghai NeuraZing Co., Ltd, Shanghai, China

This work intends to provide a preliminary evaluation of the uncertainty produced by current Tier 3 approach during the assessment of subcutaneous and partially implanted devices. The transfer function of a 600 mm long DBS and guidance wire for Interventional MRI are derived under homogeneous and heterogeneous tissue environments, respectively. The resulting power deposition using different transfer function are evaluated and compared. The results show that using current Tier 3 approach may lead to potential large underestimation of the power deposition for subcutaneous and partially implanted devices, methods which can overcome or reduce these uncertainty are needed.

4374
Booth 8
A Temperature-Insensitive Halbach Magnet Array Design for Ultra-Low-Field MRI
Ziming Huang1,2, Alex T. L. Leong1,2, and Ed X. Wu1,2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China

Halbach permanent magnet array offers lightweight and mobility but its field is sensitive to temperature, thus hindering its robust point-of-care MRI applications. This work presents a temperature-insensitive Halbach magnet array design for ultra-low-field MRI. The proposed array is of adequate bore diameter and reasonable weight (~50kg), and provides a 30 mT B0 within a 20 cm imaging field of view (FOV). Numerical simulation is conducted to test the proposed design, demonstrating a drastic reduction in temperature-induced B0 drifting and inhomogeneity.


RF Coils, Technologies & Sequences IV

Gather.town Space: North East
Room: 2
Wednesday 16:45 - 18:45
Physics & Engineering
Module : Module 24: RF Coils, Technologies & Sequences

4497
Booth 1
Coaxial Self-decoupled RF Coil
Shuyang Chai1, Yue Zhu2,3, Ming Lu2,3, John C Gore1,2,3, and Xinqiang Yan2,3

1Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 3Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Wearable RF coils are receiving increasing attention since they can improve patient comfort and maximize SNR. For wearable coil arrays, however, the geometrical relationships between coils may change when they are bent and/or stretched. This in turn may decrease the performance of conventional decoupling methods such as overlapping and L/C network, especially for transmit/receive coil where the preamp decoupling is not feasible. In this work, we proposed a novel coaxial self-decoupled coil that has robustness decoupling performance versus coil distance and coil shapes. High isolations of <-15 dB can be achieved when the coils are gapped, overlapped, and/or stretched.


4498
Booth 2
A 32-Ch Over-Overlapped Semi-Flexible RF Head Coil Array with Improved Deep Brain SNR
Yunsuo Duan1,2, Feng Liu1,2, Rachel Marsh1,2, Matthew Riddle1,2, Gaurav H. Patel1,2, John Gray1,2, Alayar Kangarlu1,2, Lawrence S. Kegeles1,2, and John T. Vaughan Jr.3

1MRI Research Center, Department of Psychiatry, Columbia University, New York, NY, United States, 2New York State Psychiatric Institute, New York, NY, United States, 3Zuckerman Institute, Columbia University, New York, NY, United States

To improve the SNR in deep brain of human head images acquired using RF coil arrays with high coil element count, we proposed a 32-ch coil array with enlarged and over-overlapped coil loop elements laid out on a semi-flexible 3D-printed coil former. The experiment results showed that both the overall homogeneity of images and the SNR in deep brain are significantly improved.

4499
Booth 3
Experimental and Numerical Simulation of the Miniature Flexible Coil for High-SNR Pituitary MRI
Siyuan Liu1, Jiahao Lin1,2, Marvin Bergsneider3, Rock Hadley4, Giyarpuram N Prashant3, Sophie Peeters3, Kyunghyun Sung2, and Robert N Candler1,5

1Electrical and Computer Engineering, University of California Los Angeles, Los Angeles, CA, United States, 2Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, 3Department of Neurosurgery, University of California Los Angeles, Los Angeles, CA, United States, 4Department of Radiology, University of Utah, Salt Lake City, UT, United States, 5California NanoSystems Institute, Los Angeles, CA, United States

We simulate and experimentally verify SNR improvement from a miniature flexible coil with the ultimate goal to identify microadenomas in the pituitary gland that are currently undetectable. Through scans of a phantom at multiple angles, we show a maximum of 12 to 20 times, and a minimum of 2 to 4 times of SNR improvements compared to the commercial head coil. We also perform high-resolution PD-TSE scans to confirm the visual improvement of our flexible coil.

4500
Booth 4
A detunable multi-row self-decoupled Transmit Array for 7 T ASL and brain spinal cord Imaging
Xinqiang Yan1,2, Yue Zhu1,2, and Ming Lu1,2

1Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 2Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Transmit arrays improves the transmit field homogeneity while reducing the local hot spot. Current array designs for the head are not optimized for arterial spin labeling and simultaneous brain and cervical spinal cord applications caused by the short longitudinal coverage. To approach this problem, we designed and constructed a three-row Tx array covering the whole brain and cervical spinal cords (length: 28 cm). The overall performance of the coil is good with return losses < -20 dB while having adjacent coils’ coupling averaging -25.3 dB and diagonal coil’s coupling averaging -14.6 dB. The coil’s detune circuit also worked as intended.

4501
Booth 5
Self-shielded and self-decoupled transmit RF array for 7T head imaging
Xinqiang Yan1,2, Yue Zhu1,2, and Ming Lu1,2

1Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 2Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Transmit (Tx) array with multiple independent coil elements is a well-recognized approach to addressing the B1 inhomogeneity and high local SAR issues at ultrahigh fields. However, Tx arrays typically have a lighter loading and more severe coil coupling. We designed a self-shielded and self-decoupled 2x8 Tx array with high inter-element isolation for 7T head imaging. Each Tx element is based on the corner-fed self-decoupled coil. Four coil elements were constructed to prove the concept is viable. The coil elements are highly decoupled (inter element response < -15 dB) while maintaining good tuning/matching characteristics (power reflection < -20 dB).

4502
Booth 6
In-silico shimming performance of a bore-sized 2-D UHF volume coil for different anatomies at 7T
Sayim Gokyar1, Henning U. Voss2, Victor Taracila3, Fraser Robb3, Douglas J. Ballon1, and Simone Winkler1

1Radiology, Weill Cornell Medicine, New York, NY, United States, 2College of Human Ecology, Cornell University, Ithaca, NY, United States, 3General Electric Healthcare, Aurora, OH, United States

We propose a two-dimensional cylindrical high-pass ladder (2D c-HPL) coil concept and investigate the contribution of the longitudinal dimension to utilize a bore-mounted general-purpose clinical volume coil for ultra-high field MRI. Theory and in-silico results show that this architecture exhibits improved B1 field uniformity for specific anatomies and regions such as brain (a coefficient of variation of 12.3%), cerebellum (4.9%), heart (16.7%), prostate (2.8%), and whole chest (36.8%). This could prove particularly useful for whole-body clinical imaging and could open new pathways for clinical diagnostics in UHF MRI.

4503
Booth 7
Hairpin Radio Frequency Coil Array with High Inter-channel isolation for 7T Magnetic Resonance Imaging
Komlan Payne1 and Xiaoliang Zhang1

1Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States

The quest for ultimate intrinsic signal-to-noise ratio (uiSNR) and higher spatial resolution at ultra-high field for parallel magnetic resonance imaging is contingent to the integrity of the magnetic flux density map from individual channel. RF coils design using hair-pin matching technique is introduced to provide intrinsic decoupling performance within array of elements. This technique does not require any additional circuit between coil elements or large value of lumped inductance to provide simultaneous decoupling between adjacent and non-adjacent coils. The simulated results including decoupling performance, field distribution, and SNR are provided to validate the feasibility of the proposed design.

4504
Booth 8
Investigation of Magnetic Wall Decoupling for planar Quadrature RF Array coils using Common-Mode Differential-mode Resonators
Komlan Payne1, Salik Inayat Khan1, and Xiaoliang Zhang1

1Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States

Parallel imaging using quadrature coil arrays can help to reach their ultimate intrinsic signal-to-noise ratio (uiSNR) and higher spatial resolution at ultra-high fields, because quadrature RF coils provide higher sensitivity and reduced excitation power over the commonly used linear polarized RF transceivers. However, due to the complicated structure and difficulties in achieving sufficient electromagnetic decoupling, it is technically challenging in designing multichannel quadrature RF coil arrays, particularly at ultrahigh fields. In this work, we design and investigate the magnetic wall decoupled common-mode differential mode quadrature RF arrays for ultrahigh field 7T MR imaging applications.

4505
Booth 9
Development of high impedance microstrip resonators for ultrahigh field MR imaging
Tianyu Gao1 and Xiaoliang Zhang2

1Biomedical engineering, University at buffalo, buffalo, NY, United States, 2Biomedical Engineering, University at buffalo, buffalo, NY, United States

Microstrip resonator has been used as the radio frequency (RF) transceiver for magnetic resonance signal excitation and reception. Its application in parallel imaging could achieve faster imaging speed and better image quality. Mutual coupling is one of the major challenges in designing a multichannel RF transceiver array required in parallel imaging technology. The mutual coupling among the array elements causes resonant frequency shift, input impedance changes, and radiation pattern change, and thus degrade the imaging quality. 

4506
Booth 10
Dielectric transreceiver resonant coil using an ultrahigh εr ceramic disk for 17O imaging at 10.5T and comparison with a single-loop surface coil
Xin Li1, Hannes M. Wiesner1, Xiao-Hong Zhu1, and Wei Chen1

1Center for Magnetic Resonance Research (UMN), Minneapolis, MN, United States

We integrated a permittivity-tunable ultrahigh dielectric constant (uHDC) disk with copper film shielding (for tuning) and a pick-up coil (for matching) for performing 17O MRS imaging (MRSI) at 10.5T. We conducted a phantom 17O imaging study to compare the coil performance and signal-to-noise ratio between the newly designed uHDC resonator with a surface loop coil of the same diameter as the disk. The results indicate a better performance of the uHDC resonator at the room temperature(21 Co), and a much better performance when the ceramic disk temperature was cooling to 16 Co, owing to a large denoising effect.

4507
Booth 11
Determination of the dielectric constant for RF passive shimming at 4T MRI
Mohan Lal Jayatilake1,2, Christopher T Sica2,3, Rommy Elyan2, Rang Pang1, Dhevin Karunanayaka2, Anupa Ekanayaka4, and Prasanna Karunanayaka2,5

1Department of Neurosurgery, Pennsylvania State University, Hershey, PA, United States, 2Center for Nuclear Magnetic Resonance Research, Pennsylvania State University, Hershey, PA, United States, 3Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, State College, PA, United States, 4Grodno State Medical University, Grodno, Belarus, 5Department of Radiology, Pennsylvania State University, Hershey, PA, United States

Optimal image quality for Magnetic Resonance Imaging (MRI) at high fields requires a homogeneous RF (B1) field; however, the dielectric properties of the human brain results in B1 field inhomogeneities, and signal loss at the periphery of the head. Selecting the appropriate permittivity and quantity of material for the shim is essential. Here, we introduce a theoretical framework for determining the requisite dielectric constant of the passive shim material directly.  

4508
Booth 12
Large benefit of RF coil B1 efficiency for X-nuclear MRS at ultrahigh field beyond the gyromagnetic ratio advantage of proton
Xin Li1, Hannes M. Wiesner1, Xiao-Hong Zhu1, and Wei Chen1

1Center for Magnetic Resonance Research (UMN), Minneapolis, MN, United States

In this study, we conducted electromagnetic simulation of a surface loop coil to quantify the B1+ transmit efficiency of five nuclei ( 1H, 31P, 23Na, 2H and 17O) from 1.5T to 21 T field strength. The simulation is validated by FID measurements. Furthermore, we investigated the loading effect on the RF coil B1+ transmit efficiency and its dependence on B0. Our study shows the X-nuclei flip angle can be reached using the same or even less coil driving voltage as for proton, thus, significantly reducing the required RF power and SAR concern.

4509
Booth 13
Improving Transmit and Receive Uniformity of 7T Brain MRI
Venkata Veerendranadh Chebrolu1, Sina Tafti2, Aaron Anderson3, and Brad Sutton3,4

1Siemens Medical Solutions USA, Inc., Rochester, MN, United States, 2Siemens Medical Solutions USA, Inc., Urbana, IL, United States, 3Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Bioengineering Department, University of Illinois at Urbana-Champaign, Urbana, IL, United States

Transmit and Receive inhomogeneity accentuate with increase in MR main magnetic field strength. Recently uniform combined reconstruction (UNICORN) was proposed to improve receive uniformity and applied for improving intensity uniformity of two­-, three-, and N-dimensional 7T MRI data. In this work, we aim to improve both receive and transmit uniformity of 7T brain MRI by applying UNICORN in combination with transmit inhomogeneity correction methods. MP2RAGE images acquired with TrueForm, patient-specific and volume-selective B1 shimming methods were processed using the UNICORN algorithm. Significant improvement in uniformity was achieved using UNICORN compared to unnormalized images.

4510
Booth 14
A multinuclear 4-channel 2H loop and 4-channel 1H microstrip array coil for human head MRS/MRI at 7T
Xin Li1, Matt Waks1, Hannes M. Wiesner1, Soo Han Soon1, Xiao-Hong Zhu1, and Wei Chen1

1Center for Magnetic Resonance Research (UMN), Minneapolis, MN, United States

A 4-channel 2H loop and 4-channel 1H microstrip head array coil with improved MRS/MRI sensitivity and imaging coverage for a human-head-like lightbulb phantom at 7T is reported. Each of the 4 2H coils is a 22cmx14cm loop, providing excellent penetration of 2H MRS signal. The 2H loops are decoupled by multiple techniques including inductive decoupling circuits and geometric overlapping, providing S12~-20dB between any pair of 2H loop coils. The majority of measured signal-to-noise ratio of the water signal originating from the natural abundance HDO content are above 100 for the voxel size of 1.7 cc.

4511
Booth 15
Performance of Short, Gradient Modulated RF Pulses due to Asynchrony Between RF and Gradient Waveforms
Chathura Kumaragamage1, Peter B Brown1, Scott McIntyre1, Terence W Nixon1, Henk M De Feyter1, and Robin A de Graaf1

1Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States

The effect of asynchrony between RF and gradient modulated (GM) waveforms on the performance of 3 ms gradient modulated GOIA-WURST RF pulses (BW = 15 kHz) was evaluated in simulation and experimentally. Results demonstrate that a 20+ μs asynchrony between RF and GM functions substantially degrades inversion performance when using large RF offsets to achieve translation. A projection-based method is presented that was used to calibrate RF and GM asynchrony on a 4T human MR system, where a  ~40 µs asynchrony was present. The projection method allows a quick calibration of RF and GM asynchrony on pre-clinical/clinical MR systems.


Safety, Low Field & Interventional III

Gather.town Space: North East
Room: 3
Thursday 14:45 - 16:45
Physics & Engineering
Module : Module 8: Safety, Low-Field, and Interventional

4818
Booth 1
Low-field Magnetic Resonance Imaging with MaRCoS
Vlad Negnevitsky1, Benjamin Menküc2, Thomas O'Reilly3, José Miguel Algarín4,5, Teresa Guallart6, Rubén Pellicer-Guridi4,5, Yolanda Vives-Gilabert7, Lincoln Craven-Brightman8, Jason Stockmann8, David Schote9, Marcus Prier10, Thomas Witzel11, Andrew Webb3, and Joseba Alonso4,5

1Oxford Ionics, Oxford, United Kingdom, 2University of Applied Sciences and Arts Dortmund, Dortmund, Germany, 3Department of Radiology, Leiden University Medical Centre, Leiden, Netherlands, 4MRILab, Institute for Molecular Imaging and Instrumentation (i3M), Spanish National Research Council (CSIC), Valencia, Spain, 5MRILab, Institute for Molecular Imaging and Instrumentation (i3M), Universitat Politècnica de València (UPV), Valencia, Spain, 6Tesoro Imaging S.L., Valencia, Spain, 7Department of Electronic Engineering, Universidad de Valencia, Valencia, Spain, 8Massachusetts General Hospital, A. A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 9Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, 10Department of Biomagnetical Resonance, Otto-von-Guericke University Magdeburg, Forschungscampus STIMULATE, Magdeburg, Germany, 11Q Bio Inc., San Carlos, CA, United States

In recent years, low-field scanners have proven their potential for clinical, preclinical, research and teaching applications. However, a critical milestone is yet to be achieved on the path to affordable, high-performance MRI systems: the availability of an inexpensive, versatile electronic control system (MR console), competitive with commercial spectrometers, but without dramatically increasing the overall scanner cost. In this work we show the status of MaRCoS (MAgnetic Resonance COntrol System), an open-source MR console and software package with powerful features, that offers higher versatility than many commercial spectrometers, and show its use in several MR setups, including in vivo acquisitions.

4819
Booth 2
Analysing the Influence of an Actively Detuned 64-channel Receive Array on SAR
Paul Mcelhinney1 and Shajan Gunamony1

1Center for Cognitive Neuroimaging, Glasgow University, Glasgow, United Kingdom

We have generated a numerical model of a 64-channel receive array at 7T and analysed its influence on SAR on an 8-channel transmit array. Simulations were conducted using a finite integration technique in CST Microwave Studio to create a model of the combined Tx/Rx system on both our phantom and the Duke human body model. Each receive element was actively detuned and implemented within our 8 channel transmit array model to provide us with an improved model from which we found that there was a negligible effect on the B1+ field and a reduction in the SAR of ~20%. 


4820
Booth 3
Comparing 1.5T MRI RF Heating Based on SAR vs. B1+RMS MR Conditional Labeling
Shiloh Sison1 and Negin Behzadian2

1Research and Development, Abbott, Sunnyvale, CA, United States, 2Abbott, sylmar, CA, United States

With the emergence of B1+RMS as a more precise RF exposure metric than SAR, implantable device manufacturers have begun MR Conditional labeling to fixed B1+RMS levels, in addition to SAR labeling. We previously characterized the relationship between wbSAR-scaled and B1+RMS-scaled RF heating of cardiac pacing leads in the context of 3T Normal Operating Mode and First Level Controlled Mode MRI exposure [1]. In this study, we extend the analysis to 1.5T.

4821
Booth 4
A mesh-based CNN for the evaluation of MR RF-induced heating of complex-shaped passive implants
Jiajun Chang1, Jianfeng Zheng1, Ran Guo1, Qianlong Lan1, Mayur Thakore2, Wolfgang Kainz3, and Ji Chen1

1Electrical and Computer Engineering, University of Houston, Houston, TX, United States, 2Stryker Corporation, Mahwah, NJ, United States, 3High Performance Computing for MRI Safety, LLC, Jasper, GA, United States

In this research, a convolutional neural network (CNN) model is developed to predict the RF-induced heating for several tibia plate systems. One thousand four hundred and sixteen device configurations were developed, and the peak 1g-average SAR values were extracted. A subset of the data was used as training set and simulation meshes were used as the input of the CNN model. Results showed a quick network convergence and high correlation. The network also had a low absolute and percentage error level. This demonstrates that one can potentially use CNN model to predict the RF-induced heating of plate systems.

4822
Booth 5
Volumetric ultrasound hyperthermia treatment using the ExAblate body MR-guided Focused Ultrasound (MRgFUS) system
Kisoo Kim1, Muhammad Zubair2, Chris J Diederich2, and Eugene Ozhinsky1

1Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Radiation Oncology, University of California, San Francisco, San Francisco, CA, United States

Hyperthermia refers to a cancer treatment by elevating tissue temperature to 40-45 °C. Hyperthermia can be achieved by clinical MRgFUS system, allowing real-time temperature monitoring for the precise control of hyperthermia heating. Currently the ExAblate is MR-guided FUS ablation system with the largest installation worldwide, however, requires advanced beamforming strategies for volumetric hyperthermia. This study proposed electronic beam steering, multi-focal patterns, and sector-vortex beamforming approaches in conjunction with partial array activation and was evaluated in biothermal simulations and phantom experiments. This study demonstrated the feasibility of sustained large volume heating with MR thermometry feedback using the ExAblate body system.

4823
Booth 6
Workflow for Personalized RF Safety Assessment of Orthopedic Implants in MRI, a Proof of Concept
Peter Stijnman1,2, Bart Steensma1, Gerrit Melis3, Cornelis van den Berg1, and Alexander Raaijmakers4

1Computational Imaging, UMC Utrecht, Utrecht, Netherlands, 2Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 3Radiology, UMC Utrecht, Utrecht, Netherlands, 4Eindhoven University of Technology, Eindhoven, Netherlands

Patients with non-labelled implants are often ineligible for MRI. Sometimes non-labelled implants are scanned by some hospitals based on literature and empirical insights, power constraints are abided to avoid tissue heating. Using an accelerated simulation method we demonstrate a proof of concept workflow to obtain the patient-specific SAR increase for multiple patient and implant positions within 2-3 hours. This workflow uses two orthogonal X-ray images to construct a 3D model of the implant which is inserted in a human model. The method enables more accurate scanning constraints and, a more informed risk vs benefit analysis for each patient.

4824
Booth 7
Impact of RF Frequency Variation on AIMD MRI RF Safety Assessment
Xin Huang1, Xiyao Xin1, Kevin Feng1, Vick Chen1, and Shiloh Sison1

1Abbott Laboratories, Sylmar, CA, United States

To assess the impact of RF frequency variation on AIMD MRI RF safety, the tangential electric field and cardiac pacing lead electrode RF heating transfer functions were obtained at different frequencies: around 64 MHz for 1.5T scanners and 128 MHz for 3T scanners. The result shows that the impact on in vivo RF heating prediction due to RF frequency shift is insignificant.

4825
Booth 8
Design of a permanent magnet for a 0.55 T tabletop MRI
Feng Jia1, Sebastian Littin1, Philipp Amrein1, and Maxim Zaitsev1,2

1Department of Radiology, Medical Physics, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 2High Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria

Optimize the shape of pole shoes of a 0.55 T permanent magnet to increase the homogeneity of the main magnetic field in a region of interest.

4826
Booth 9
The Potential of AI-Based Clinical Text Mining to Improve Patient Safety: the Case of Implant Terms and Patient Journals
Marina Santini1, Oskar Jerdhaf2, Anette Karlsson2, Emma Eneling3, Magnus Stridsman3, Arne Jönsson4, and Peter Lundberg2,5

1Digital Health, Research Institutes of Sweden (RISE), Stockholm, Sweden, 2Radiation Physics, Linköping University, Linköping, Sweden, 3Unit for Technology Assessment, Testing and Innovation and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden, 4Department of Computer and Information Science, Linköping University, Linköping, Sweden, 5Center for medical Imaging and Visualization (CMIV), Linköping, Sweden

It is important for radiologists to know in advance if a patient has an implant, since MR-scanning is incompatible with some implants. At present, the unbiased process to ascertain whether a patient could be at risk is manual and not entirely reliable. We argue that this process can be enhanced and accelerated using AI-based clinical text-mining. We therefore investigated the automatic discovery of medical implant terms in electronic-medical-records (EMRs) written in Swedish using an AI-based text mining algorithm called BERT. BERT is a state-of-the-art language model trained using a deep learning algorithm based on transformers. Results are promising.   

4827
Booth 10
MRI Gradient Induced Device Heating of Leadless Pacemakers
Michael Childers1, Dorab Sethna1, Vick Chen1, and Shiloh Sison2

1Abbott, Sylmar, CA, United States, 2Abbott, Sunnyvale, CA, United States

Simulations and benchtop testing were performed to assess potential gradient induced device heating of leadless pacemakers. Results of the evaluation showed leadless pacemakers sized objects, made from commonly used conductive materials, heated less than 1°C when exposed to the gradient induced device heating safety test conditions per ISO/TS 10974.  In general, a temperature rise less than 2°C is considered to be clinically insignificant. As such, the risk of leadless pacemaker gradient induced device heating is negligible and assessments for this hazard per ISO/TS 10974 may not be necessary.

4828
Booth 11
Evaluation of 3D Tailored Excitation Sequences on the MRI Safety Assessment of Transvenous Implantable Pacemaker, ICD or CRT System
Kevin Feng1, Ruoli Jiang1, and Shiloh Sison1

1Abbott Laboratories, Sylmar, CA, United States

A 3D tailored excitation sequence at 3T was found to have peak RF simultaneous with gradient slewing. The exposure levels generated by this sequence were determined and impact to the transvenous implantable pacemakers, implantable Cardioverter Defibrillators (ICDs) and Cardiac Resynchronization Therapy (CRT) systems safety evaluation of RF and gradient voltages was assessed. It is demonstrated that the combined RF and gradient level is expected to be covered by the separate RF and gradient test level required by ISO/CD 10974, and the bandwidth of the 3D sequence is well within the frequency ranged specified in ISO/CD 10974.

4829
Booth 12
QSM as a Potential Treatment Efficacy Indicator for MR-HIFU-mediated Histotripsy
Johannes Lindemeyer1, Lukas Christian Sebeke1, Ari Partanen2, Christian Lucas Haas1, and Holger Grüll1,3

1Department of Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany, 2Profound Medical Inc, Mississauga, ON, Canada, 3Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany

High intensity focused ultrasound-mediated histotripsy is a modality for targeted, non-invasive interventions. As temperature changes detected by MR-thermometry are not directly related to histotripsy treatment success, we propose quantitative susceptibility mapping (QSM) to evaluate and monitor treatment efficacy. Fresh porcine heart muscle tissue was sonicated using a clinical MR-HIFU system. Herein, we demonstrate the successful visualization of histotripsy-induced lesions by QSM.

4830
Booth 13
Comparison of RF-Induced Heating of a Vascular Stent in an ASTM Phantom and Two Virtual Human Anatomies in Open and Closed Bore MRI Systems
Eric D. Anttila1, Grant M. Baker1, Alan R. Leewood1, Seoggwan Kim1, and David C. Gross1

1MED Institute Inc., West Lafayette, IN, United States

The primary goal of this study was to compare radiofrequency (RF) induced temperature rises of a stent within the ASTM phantom and two virtual human anatomies in a 1.2 T Hitachi Oasis open bore, 1.5 T Siemens Altea closed bore, and 3.0 T Siemens Prisma closed bore MRI systems for the purpose of MRI labeling according to ASTM F25031. The secondary goal was to simulate RF-induced heating of the same stent within the Duke virtual human model containing 1) internal organs with individual material properties and 2) no internal organs and average tissue properties throughout and compare predicted temperature rises.


New Systems & Devices IV

Gather.town Space: North East
Room: 5
Thursday 17:00 - 19:00
Physics & Engineering
Module : Module 32: New Systems & Devices

5023
Booth 1
Application of the template-based attenuation correction to simultaneous MR-PET brain imaging of non-human primates
Chi-Hyeon Yoo1, Jonathan DuBois2, Lu Wang3, Steven Liang4, David Izquierdo-Garcia1, and Hsiao-Ying Wey1

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, 2Biogen, Cambridge, MA, United States, 3Department of Nuclear Medicine and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University & Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, China, 4Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

The goal of this study was to generate a population-based template/atlas and apply the template/atlas-based attenuation correction (AC) method for simultaneous positron-emission-tomography/magnetic-resonance-imaging (PET/MRI) neuroimaging studies on non-human primates (NHPs). Population-based template/atlas of computed tomography image and anatomical MRI, were generated from ten NHPs (rhesus macaque). By using the generated template/atlas, the linear attenuation coefficient (LAC) of objects can be reliably derived, showing good differentiation for tissues, also skull and air. Comparison of the PET images reconstructed by the template/atlas-based and simple threshold-based AC has shown that the template/atlas-based AC can increase PET signal by avoiding overcompensation of attenuation. 

5024
Booth 2
Noncontact in-bore cardiopulmonary sensing using CW doppler radar
Wonje Lee1, Kanghyun Ryu1, Fraser Robb2, John Pauly3, Shreyas Vasanawala1, and Greig Scott3

1Radiology, Stanford University, Stanford, CA, United States, 2GE healthcare, Cleveland, OH, United States, 3Electrical Engineering, Stanford University, Stanford, CA, United States

Noncontact vital sensing applications have great potential to aid in patient care. We leverage a reconfigurable SDR to assess the feasibility of in-bore cardiopulmonary sensing using CW doppler radar that operates independently of the MRI system and data acquisition. 

5025
Booth 3
Spherical Harmonic Active Shim Set Design for a Shoulder Cut-out MRI Platform
Eric J Lessard1, William B Handler1, and Blaine A Chronik1

1Western University, London, ON, Canada

This simulation and electromagnetic design work explored the development of an active second order spherical harmonic shim set for eddy current compensation in a shoulder cut-out head and neck imaging platform. While the small radius shoulder cut-out shims can be driven faster and stronger than the larger radius complete cylinder shims they suffer in homogeneity and eddy current compensation. This difference in compensation is minimized with the addition of two purpose designed eddy current compensation coils.

5026
Booth 4
MC-ECLIPSE for arbitrary ROI shaping and whole brain shimming for 3D MRSI
Chathura Kumaragamage1, Peter B Brown1, Scott McIntyre1, Terence W Nixon1, Henk M De Feyter1, and Robin A de Graaf1

1Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States

ECLIPSE, a pulsed second order gradient insert can provide robust lipid suppression over an elliptical ROI for applications in human brain MRSI. While ECLIPSE provides excellent axial slice coverage for brain shapes that closely resemble an ellipse, coverage can be compromised for other head shapes. The development of an ECLIPSE gradient coil in combination with a 54-channel multi-coil array (MC-ECLIPSE), that allows B0 field shaping for arbitrary ROI generation is presented. Simulation results demonstrate that near-perfect (99%) axial slice coverage is achievable with MC-ECLIPSE, for a wide range of highly asymmetrical brain and head shapes.

5027
Booth 5
Spatial encoding with a 48-ch Transcranial Magnetic Stimulation coil array: Application to diffusion imaging
Jason Peter Stockmann1,2, Lucia Navarro de Lara1, Mohammed Daneshzand1, Qinglei Meng1, Congyu Liao3, Hong-Hsi Lee1,2, Lawrence L Wald1,2, Berkin Bilgic1,2, Susie Huang1,2, and Aapo Nummenmaa1,2

1A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Lucas Center, Stanford University, Stanford, CA, United States

We show that multi-channel TMS (mTMS) probe arrays can be used to generate B-fields inside the head for spatial encoding in concurrent TMS/MRI studies.  We assess the field-synthesis capability of a 48-ch mTMS array for diffusion imaging and spatial encoding more broadly.  Proof-of-concept diffusion imaging experiments on a 3T scanner using a 3-axis TMS probe achieve spatially-varying b-values >500 s/mm2 at the depth of the peripheral gray matter using only 4A of current.  We consider the potential for scaling up to 200A for studies of gray matter microstructure.  

5028
Booth 6
Improving the performance of integrated RF-B0 shim array using 3D coil elements with orthogonal loops
Siyu Li1 and Danny JJ Wang1

1Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States

B0 field inhomogeneity can reduce the effectiveness of RF pulses, result in signal voids, blurring and image artefacts. Integrated RF-shim coil arrays1,2,3 offer capabilities for concurrent parallel RF reception and local B0 shimming, and is superior to spherical harmonic shimming. However, its performance may still be limited due to the lack of flexibility for shimming and limited depth penetration for signal reception. We simulated the B0 shimming performance of a range of integrated RF-shim coil arrays with 3D orthogonal loop coil geometry, and compared the results with standard 2D loop coil arrays.


5029
Booth 7
A Proposed Method for Retuning an RF Coil by Changing the Shield Radius for Multinuclear Imaging
Kieffer Davieau1, Matthew Fox1,2, Blaine Chronik1,3, and Alexei Ouriadov3,4

1Medical Biophysics, Western University, London, ON, Canada, 2Lawson Health Research Institute, London, ON, Canada, 3Physics and Astronomy, Western University, London, ON, Canada, 4School of Biomedical Engineering, Western University, London, ON, Canada

This study investigates the feasibility of changing the shield radius of an RF coil to shift the resonant frequency from 1H to 19F for multinuclear imaging. The method proposed in this investigation was verified by changing the resonant frequency of a 129Xe RF Coil a total of 1.18 MHz by changing the shield radius, allowing it to be used in a 2.9T Siemens MRI and a 3.0T GE MRI. It was found that altering the shield radius had similar effects on the resonant frequency as using a variable tuning capacitor, allowing for one coil to be compatible with multiple scanners.

5030
Booth 8
A Truncated Twisted Solenoid RF Phase Gradient Transmit Coil for TRASE MRI
Christopher James Sedlock1, Aaron Purchase1, Boguslaw Tomanek1, and Jonathan Sharp1

1University of Alberta, Edmonton, AB, Canada

TRASE is an MR imaging sequence that achieves k-space encoding through the use of phase gradients in the RF transmit field. The twisted solenoid is the most efficient RF transmit coil used for TRASE encoding; however, the geometry results in a long coil with a relatively short imaging volume. We introduce a new truncated design for the twisted solenoid to increase the usable imaging volume relative to the coil’s size. Simulation studies conducted indicate the truncated design can create similar imaging volumes to the untruncated version whilst significantly reducing the coils length by as much as a half.


5031
Booth 9
Mobile application based monitoring system for RF coils at 7T Magnetic Resonance Imaging
Sri Kirthi Kandala1, Alberto Fuentes2, Gregory H Turner2, and Sung-Min Sohn1

1Arizona State University, Tempe, AZ, United States, 2Barrow-ASU Center for Preclinical Imaging, Phoenix, AZ, United States

Like most modern electronic devices, a mobile application based Radio Frequency (RF) coil monitoring system will make it easy to carry out any real-time changes to the RF coil. This work focuses on developing a mobile application based RF monitoring system, that allows the user to gather real-time RF coil characteristics and control the coil. It gives the user a chance to make changes when necessary. The opportunity to wirelessly implement such changes without physical contact with the coil, using a mobile application via Bluetooth is a step in the direction towards building next-generation RF coils for MRI.

5032
Booth 10
Distortion Measurements Using a Large-volume, Lightweight, Modular MRI Phantom With Solid Signal Sources
Mariko Gardiner1, Keith Wachowicz2,3, and Nicola De Zanche2,3

1University of Alberta, Edmonton, AB, Canada, 2Oncology, University of Alberta, Edmonton, AB, Canada, 3Medical Physics, Cross Cancer Institute, Edmonton, AB, Canada

Phantoms that cover large volumes are required to characterize geometrical distortion for image-guided interventions such as MR-guided radiation therapy (linac-MR). Liquid-filled phantoms of appropriate size can, however, be impractically heavy. Our phantom uses silicone rubber spheres arranged on a three-dimensional grid, resulting in a lightweight, portable structure. Displacements of each bead relative to the known grid positions are calculated in Matlab or 3D Slicer from 3D bSSFP scans. Design files and image processing code are available online.

5033
Booth 11
Combined Stiffness and PDFF Phantom for Quality Assurance of Quantitative Magnetic Resonance Elastography and Fat Fraction Imaging
David Rutkowski1, Alejandro Roldán-Alzate2,3,4, José Guerrero-González1, Diego Hernando1,3,5, Scott B Reeder1,3,4,5,6,7, and Jean H Brittain1

1Calimetrix, Madison, WI, United States, 2Mechanical Engineering, University of Wisconsin, Madison, WI, United States, 3Radiology, University of Wisconsin, Madison, WI, United States, 4Biomedical Engineering, University of Wisconsin, Madison, WI, United States, 5Medical Physics, University of Wisconsin, Madison, WI, United States, 6Medicine, University of Wisconsin, Madison, WI, United States, 7Emergency Medicine, University of Wisconsin, Madison, WI, United States

MRI proton density fat fraction (PDFF) and MR elastography (MRE) methods are frequently used to evaluate patients with known or suspected NAFLD or NASH. Reference standards (phantoms) are needed for quality assurance of these methods. Currently available phantoms mimic only a single tissue property. A phantom that simultaneously mimics PDFF and tissue stiffness would more realistically mimic NAFLD/NASH tissue and would enable robust and convenient quality assurance.  In this work, a chemical formulation and phantom configuration were developed for a multi-layer combined PDFF-MRE phantom, in which each layer simultaneously mimics different PDFF and stiffness values.

5034
Booth 12
Modular, 3D Printed, Open-source Phantoms for Small Animal Systems
Mariko Gardiner1, Anthony G. Tessier2, Keith Wachowicz2,3, and Nicola De Zanche2,3

1University of Alberta, Edmonton, AB, Canada, 2Medical Physics, Cross Cancer Institute, Edmonton, AB, Canada, 3Oncology, University of Alberta, Edmonton, AB, Canada

Phantoms for pre-clinical systems have not been standardized, and none in the literature permit the wide variety of measurements possible with the ACR phantoms. We present a low-cost, open-source, modular phantom made of 3D-printed and off-the-shelf parts that mimics the functionality of the ACR phantoms on an appropriate scale. Standard, inexpensive manufacturing techniques are sufficient to create the fine features required at this scale. Configuration of the phantom can be customized to suit each site’s needs. Possible measurements include image uniformity, distortion and SNR; slice location, thickness, and angle; radial, linear, and low-contrast resolution.

5035
Booth 13
Low-cost MR-compatible pneumatic respiratory motion simulator for development of MR-guided therapies
Kisoo Kim1, Peter Jones2, Chris J Diederich2, and Eugene Ozhinsky1

1Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Radiation Oncology, University of California, San Francisco, San Francisco, CA, United States

We developed a low-cost and simple MR-compatible respiratory motion simulator to support proof-of-concept studies of MR monitoring approaches with respiration-induced organ motion. The motion system integrates pneumatic control via an actuator subsystem outside the MRI and coupled via plastic tubing to a compressible bag for distention and retraction within the MRI motion subsystem and phantom within the MRI scanner. The proposed respiratory motion simulator provided consistent periodic respiratory motion with displacement in the range 3.7-9.0 mm. The respiratory simulator could be easily assembled with off-the shelf and 3D-printed parts, based on open-source design models.

5036
Booth 14
Evaluation of High Resolution Diffusion MRI on the Next-Generation 7T scanner
An T Vu1,2, Alexander JS Beckett3,4, Salvatore T Torrisi3,4, Sinyeob Ahn5, Michael Koehler6, Peter Dietz6, and David A Feinberg3,4

1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Radiology, San Francisco Veteran Affairs Health Care System, San Francisco, CA, United States, 3Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United States, 4Advanced MRI Technologies, Sebastopol, CA, United States, 5Siemens Medical Solutions USA, Inc., Melvern, PA, United States, 6Siemens Healthcare, Erlangen, Germany

The newly developed head gradient (200 mT/m Gmax, 900 T/m/s SR) on the new NexGen 7T system provides many potential benefits for high-resolution diffusion imaging. Faster, stronger gradients can significantly reduce diffusion encoding times and TE for up to a 3-fold improvement SNR while also reducing TR and total scan time. We demonstrate these benefits in high resolution diffusion imaging applications with b-values of up to 10,000 s/mm2 at 7T.

5037
Booth 15
MR-Assisted PET Respiratory Motion Correction Using Deep-Learning Based Short-Scan Motion Fields
Sihao Chen1, Tyler J. Fraum1, Cihat Eldeniz1, Joyce Mhlanga1, Weijie Gan1, Thomas Vahle2, Uday B. Krishnamurthy3, David Faul4, H. Michael Gach1, Michael M. Binkley1, Ulugbek S. Kamilov1, Richard Laforest1, and Hongyu An1

1Washington University in St. Louis, Saint Louis, MO, United States, 2Siemens Healthcare GmbH, Erlangen, Germany, 3Siemens Medical Solutions USA, Saint Louis, MO, United States, 4Siemens Medical Solutions USA, Malvern, PA, United States

Respiratory motion causes signal blurring and image artifacts. Simultaneous PET/MRI allows for MR-assisted motion correction (MoCo) in PET imaging, leading to improved PET images for detection and evaluation of lesions. In this study, we proposed and examined a PET MoCo approach using motion vector fields (MVFs) from a deep-learning reconstructed MRI scan. MRI-based MVFs were derived from either 2000 spokes (MoCo2000, 5-6 minutes acquisition time) using a Fourier transform reconstruction or 200 spokes (MoCoP2P200, 30-40 seconds acquisition time) using a deep-learning Phase2Phase (P2P) reconstruction and then incorporated into PET MoCo reconstruction.


New Systems & Devices V

Gather.town Space: North East
Room: 6
Thursday 17:00 - 19:00
Physics & Engineering
Module : Module 32: New Systems & Devices

5038
Booth 1
Validation of motion-robust, blood-suppressed, reduced-distortion liver diffusion techniques in a pulsatile motion phantom
Ruiqi Geng1,2, James Rice1,3, Yuxin Zhang1,2, David R. Rutkowski1,3, Alejandro Roldán-Alzate1,3, Arnaud Guidon4, and Diego Hernando1,2,5,6

1Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 3Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 4GE Healthcare, Boston, MA, United States, 5Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI, United States, 6Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States

Conventional liver diffusion MRI acquisitions suffer from several challenges including pulsatile motion-induced signal voids and B0-induced distortions. In this study, we validated motion-robust, blood-suppressed, reduced-distortion liver diffusion techniques in an anatomically accurate liver phantom including controlled pulsatile motion. By combining optimized motion-compensated, blood-suppressed diffusion waveforms (i.e. MODI) with msEPI acquisitions, superior image quality and quantitative performance can be achieved in the presence of various degrees of compressive tissue motion.

5039
Booth 2
Impact of Fat Droplet Sizes on R2* in Fat-Iron phantoms for Accurate Assessment of Hepatic Steatosis and Iron Overload Using MRI
Sarah Caroline Brasher1, Cara Morin2, and Aaryani Tipirneni-Sajja1,2

1Biomedical Engineering, University of Memphis, Memphis, TN, United States, 2St. Jude Children's Research Hospital, Memphis, TN, United States

R2* correction is necessary for improving the accuracy of fat fraction quantification in assessing steatosis. However, the dephasing effects of concurrent iron overload may be dependent on the size of iron and fat particles. In this study, we controlled the size of fat droplets in fat-iron emulsion phantoms by traditional stir bar methods and homogenization. R2* and far fraction (FF) values were estimated with multi-spectral models that assume a common or independent R2* for water and fat. Our results show that R2* was slightly reduced in homogenized phantoms at higher fat fractions compared to stir bar phantoms.

5040
Booth 3
Acceptance Procedure for the MRI Component of the 1.5T MRI-Linac
Jie Deng1, Chenyang Shen1, Justin Visak1, and Andrew Godley1

1Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, United States

On two Unity MRI-Linac systems simultaneously installed in our institution in May 2021, we developed and implemented the acceptance and commissioning testing for the MRI component independently. We also worked together with the vendors during troubleshooting and re-testing processes. The comprehensive acceptance testing consisted of 4 phases: basic testing using vendor-provided tools, advanced testing, Linac system influence on MRI, and end-to-end testing for treatment planning and dose delivery. Both Unity machines successfully passed the MRI component acceptance testing in consideration of influence of the Linac component. MR-to-MV alignment defect on one system was fixed after major work of troubleshooting.

5041
Booth 4
Impact of gradient scheme and shimming on out-of-voxel echo artefacts in edited MRS
Yulu Song1,2, Helge J. Zöllner1,2, Steve C.N. Hui1,2, Georg Oeltzschner1,2, and Richard A.E. Edden1,2

1Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Out-of-voxel (OOV) signal is a common spurious echo artifact, which interferes with spectral quantification. These signals arise from either incomplete suppression or accidental refocusing. Dephasing Optimization Through Coherence Order Pathway Selection (DOTCOPS) is an optimized gradient scheme that can be used to suppress unwanted signals. Here we explored the impact of gradient scheme and shimming-order on OOV artefacts in Hadamard-encoded edited MRS.

5042
Booth 5
Error Propagation in Absolute Metabolite Quantification for MR Spectroscopy of the Human Brain
Ronald Instrella1 and Christoph Juchem1,2

1Biomedical Engineering, Columbia University, New York, NY, United States, 2Radiology, Columbia University, New York, NY, United States

Spectral quantification methods provide absolute concentration estimates of metabolites from data acquired using in vivo MR spectroscopy. Cramér-Rao Lower Bounds (CRLB) are commonly employed as a minimum estimate of concentration error; however, absolute quantification relies on more than simply the uncertainty of Linear Combination Modeling (LCM). The uncertainties of both metabolite (e.g. T1, T2) and sequence-specific parameters (e.g. TR, TE), are generally ignored, leading to a systemic overestimation of accuracy. In this study, we present an analysis using the propagation of uncertainty to derive a more comprehensive estimate of the overall error of metabolite quantification.

5043
Booth 6
Evaluation of a prototype MR conditional hoverboard and stirrups system for MR-guided brachytherapy at 3T
Evangelia Kaza1, Bret Nicholson2, Kevin Anderson2, Jesse Drake2, Alex Marques1, Steven Hatch1, Jeremy Bredfeldt1, Martin King1, and Atchar Sudhyadhom1

1Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States, 2Diacor Inc, West Valley City, UT, United States

MR conditional stirrups would be beneficial in MR-guided gynecological and prostate brachytherapy but have not been clinically available. Evaluation of a prototype Diacor MR conditional board and stirrups system revealed no significant projectile or heating risks at 3T. The maximum temperature measured on its metallic surfaces after scanning was 22 ⁰C, relating to a 3 ⁰C increase. The stainless steel blades of the stirrup joints caused signal cancellation artifacts which extended radially up to 23cm on phantom images. On volunteer scans, artifacts were observed in posterior hip areas only. Pelvic organ visualization was considered suitable for brachytherapy treatment planning.

5044
Booth 7
Mock TcMRgFUS Transducer for Off-site Technological Development
Rock Hadley1, Robb Merrill1, Henrik Odeen1, and dennis parker1

1University of Utah, Salt Lake City, UT, United States

A portable device that mimics the shape, size, and configuration of the Insightec transcranial MR guided focused ultrasound (tcMRgFUS) assembly is presented. This Mock system provides a water bath and conductive ground plane that accurately emulates that of the Insightec system.  The system is shown to generate the same well-known banding artifact as the Insightec system. The construction details of the Mock system and image comparison to the Insightec system are presented.

5045
Booth 8
PET Recon with MR Priors: Application in Ambiguously Rated Amyloid PET Scans
Mehdi Khalighi1, Greg Zaharchuk1, Michael Zeineh1, Guido Davidzon1, Gabriel Kennedy2, Christina Young1, Michael Greicius2, Kathleen Poston2, and Elizabeth Mormino2

1Radiology, Stanford University, Stanford, CA, United States, 2Neurology, Stanford University, Stanford, CA, United States

A recently developed PET recon with MR priors and motion correction method is applied to a set of ambiguously rated amyloid PET scans and is compared with regular TOF-OSEM PET recon using SUVR. The same comparison is done in a set of scans which were matched by clinical diagnosis. By using PET recon with MR priors, lower SUVRs for negative scans compared to increased SUVRs for positive scans were measured, which shows improvement in the ability to distinguish intermediate amyloid levels.

5046
Booth 9
Concomitant Field Effects on Asymmetric Gradient Systems: Impacts on Slow Flow Imaging
Nastaren Abad1, Seung-Kyun Lee1, Yihe Hua1, J. Kevin DeMarco2,3, Robert Shih2,3, Maureen Hood2,3, H Doug Morris2, Vincent B Ho2,3, Myung-Ho In4, Matt A Bernstein4, and Thomas KF Foo1

1GE Global Research Center, Niskayuna, NY, United States, 2Walter Reed National Military Medical Center, Bethesda, MD, United States, 3Uniformed Services University of the Health Sciences, Bethesda, MD, United States, 4Department of Radiology, Mayo Clinic, Rochester, MN, United States

This study investigates concomitant gradient field effects on gradient echo phase contrast imaging when visualizing very slow (<50 mm/s) flow. The impact of real-time concomitant field compensation and the consequence of uncompensated higher-ordered terms is shown.


5047
Booth 10
In Scan Room No-Interference High Efficiency Switching Power Supply with GaN
Juan A Sabate1, Logan A Snow1, Huan A Hu1, and Randy Buchwald2

1GE Research, Niskayuna, NY, United States, 2MR-Eng-Systems, GE Healthcare, Waukesha, WI, United States

A switching regulator implemented with GaN power semiconductors and air core inductors was shown not to create any noise that affected the scanner imaging. This was due to the selected switching frequency of 2.489MHz, which avoided harmonics at imaging frequencies of interest. The switching regulator size and thermal management at 90% does not require any additional support systems in the scan room. This demonstrates that GaN-based switching regulators can be a good solution to regulate voltages in the scan room and also significantly reduce the cabling and simplify installation.

5048
Booth 11
Comparison of simulated parallel transmit head arrays at 7T using excitation uniformity, local SAR, and global SAR
Ehsan Kazemivalipour1,2, Lawrence L. Wald1,2,3, and Bastien Guerin1,2

1A.A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Harvard-MIT Division of Health Sciences Technology, Cambridge, MA, United States

We investigate the performance of parallel transmission arrays with 8, 16, 24, and 32 channels and varying loop sizes (18 coils total) for brain imaging at 7T. We compare RF-shimming performance of the arrays using the L-curve method showing optimal tradeoffs between excitation uniformity (slice), local-SAR, global-SAR and peak-power. For the numbers of channels simulated here, the coils with larger loops achieved a better local-SAR vs. excitation uniformity than those with smaller loops (this was true for axial/sagittal slice orientations). At constant local-SAR constraint, the 24-channel arrays showed the best performance in improving the excitation uniformity in the coronal/axial slices.

5049
Booth 12
High-resolution whole-brain diffusion MRI at 7 Tesla using 63-channel signal reception
Xiaodong Ma1, Andrea Grant1, Matt Waks1, Edward Auerbach1, Gregor Adriany1, Kamil Ugurbil1, and Xiaoping Wu1

1Center for Magnetic Resonance Research, Radiology, Medical School, University of Minnesota, Minneapolis, MN, United States

There has been an increasing interest to acquire high-resolution diffusion MRI at ultrahigh field (≥7 Tesla) due to the increased SNR and improved parallel imaging performance. To fully capitalize on the benefit of ultrahigh field, it is desirable to image with many receiver coils. In this study, we acquired slice-accelerated whole-brain 1.05-mm isotropic diffusion images on an FDA-approved 7 Tesla scanner (Siemens Terra) using a homemade 63-channel head RF array with various slice and in-plane accelerations. We found that the use of 63 channels can achieve higher acceleration factors (up to  9-fold acceleration in total) while maintaining the image quality.

5050
Booth 13
Higher-order image reconstruction with integrated gradient nonlinearity correction using a low-rank encoding operator
Nam G. Lee1, Kübra Keskin2, Ziwei Zhao2, and Krishna S. Nayak2

1Biomedical Engieering, University of Southern California, Los Angeles, CA, United States, 2Electrical Engieering, University of Southern California, Los Angeles, CA, United States

Conventional MR image reconstruction relies on the assumption of perfectly linear gradient fields. However, the gradient fields contain spatially varying nonlinear components. We present a higher-order image reconstruction method that incorporates a theoretical model of gradient nonlinearity without any external field monitoring device. This approach utilizes the separability of Fourier encoding in Cartesian imaging and employs a low-rank approximation only to the higher-order readout encoding matrix, allowing a memory-efficient implementation suitable for large FOVs. Image distortions due to gradient nonlinearity were successfully mitigated by the proposed method using axial/sagittal/coronal 2D Cartesian datasets acquired on a prototype 0.55T MRI system.