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| 2650 | Deep-learning Methods for Meniscus Segmentation in Knee MRI | |
| Siyue Li1, Shutian Zhao1, Sheheryark Khan1, and Weitian Chen1 | ||
1CUHK lab of AI in radiology (CLAIR), Department of imaging and interventional radiology , The Chinese university of Hong Kong, HongKong, Hong Kong |
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Meniscus segmentation in MR images has important clinical applications. Due to its large shape variation and low contrast with surrounding pixels, it is challenging to perform robust and reliable meniscus segmentation automatically. We investigated deep-learning network V-Net approaches for meniscus segmentation using MR images. |
| 2651 | Discrimination of subjects with and without knee osteoarthritis using a radiomics approach on tibial bone | |
| Jukka Hirvasniemi1, Stefan Klein2, Dieuwke Schiphof3, and Edwin Oei1 | ||
1Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands, 2Department of Radiology & Nuclear Medicine and Department of Medical Informatics, Erasmus MC, Rotterdam, Netherlands, 3Department of General Practice, Erasmus MC, Rotterdam, Netherlands |
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Radiomic features were automatically extracted from tibial bone using knee MRI data of 665 women and the ability of the features to discriminate subjects with and without osteoarthritis was assessed. An area under the receiver operating characteristics curve of 0.80 was obtained for classifying subjects with and without osteoarthritis using an elastic net regression model that included radiomic features and covariates. Our results indicate that tibial bone characteristics are different between subjects with and without knee osteoarthritis. |
| 2652 | Automated Segmentation of Knee Articular Cartilage on MRI Data: Increasing Network Capacity with Transfer Learning | |
| Dimitri A Kessler1, James W MacKay1,2, Fiona J Gilbert1, Martin J Graves1, and Joshua D Kaggie1 | ||
1Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 2Norwich Medical School, University of East Anglia, Norwich, United Kingdom |
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In this study we evaluated the possibility of using transfer learning to improve the segmentation accuracy of femoral and tibial knee articular cartilage of a small locally acquired and annotated dataset. Two conditional Generative Adversarial Networks were trained - one with pretraining on the much larger SKI10 (Segmentation of Knee Images 2010) dataset and the other with random weight initialisation and no pretraining. Pretraining not only increased cartilage segmentation accuracy of the fine-tuned dataset, but also increased the network’s capacity to preserve segmentation capabilities for the pretrained dataset. |
| 2653 | Compartment-specific Knee Cartilage Segmentation using Deep Learning | |
| Egor Panfilov1, Aleksei Tiulpin1,2, Victor Casula1, Simo Saarakkala1,2, and Miika T. Nieminen1,2 | ||
1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 2Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland |
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In this study, we developed a method for compartment-specific segmentation of knee cartilage from 3D-DESS MR images which jointly utilizes deep learning and atlas-based approaches. The method was applied to compare the performance of two deep learning-based segmentation models on two independent datasets. One of the models achieved new state-of-the-art in knee cartilage segmentation on the Osteoarthritis Initiative data and was more robust to the changes in MRI protocol. Detailed analysis performed using our method showed how the performance improvements are localized compartment-wise. The method can be used to select the most accurate segmentation model for the considered clinical problem. |
| 2654 | Deep learning fat-suppressed images for musculoskeletal diseases | |
| Shimpei Kato1,2, Akihiko Wada1, Yuya Saito1,3, Christina Andica1, Shohei Fujita1,2, Kotaro Fujimoto1,2, Yutaka Ikenouchi1, Akifumi Hagiwara1, Junko Kikuta4, Kanako Sato1,2, Michimasa Suzuki1, Toshiaki Akashi1, Maki Amano1, Koji Kamagata1, Kanako Kumamaru1,2, Masaaki Hori1,5, Atsushi Nakanishi1, Osamu Abe2, and Shigeki Aoki1 | ||
1Department of Radiology, Juntendo University, Tokyo, Japan, 2Department of Radiology, The University of Tokyo, Tokyo, Japan, 3Faculty of Health Sciences Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, 4Department of Radiology, Juntendo University Nerima Hospital, Tokyo, Japan, 5Department of Radiology, Toho University, Tokyo, Japan |
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Fat-suppressed MR images of the musculoskeletal system help the visualization of T2-prolonged lesions, such as tumors, infections/inflammations, and trauma, with better contrast, while also contributing to the qualitative diagnosis of fatty lesions.However, the addition of a fat-suppressing sequence to clinical routine is time-consuming. Increasing the imaging time may lead to deterioration of the image quality due to body movement.In this study, we generated fat-suppressed images through post-processing by using deep learning. The images were generated using U-Net, with T1WIs and T2WIs as input. The generated images were very similar to Dixon images that were used as targets. |
| 2655 | Texture Analysis of T2-weighted Lumbar Spine MRI Predicts Presence of Low Back Pain | |
| Juuso Heikki Jalmari Ketola1, Satu Irene Inkinen1, Jaro Karppinen2, Jaakko Niinimäki1,2,3, Osmo Tervonen1,2,3, and Miika Tapio Nieminen1,2,3 | ||
1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 2Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, 3Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland |
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We applied texture analysis to T2-weighted MRI of the lumbar spine in a population-based sample. The extracted features were used in a logistic regression pipeline to predict whether the subjects (N=200) suffered from clinically relevant low back pain. Best results were obtained by combining features from intervertebral discs and vertebrae with receiver operating characteristics area under curve of 0.86, accuracy of 0.84, and recall of 0.83. This preliminary work shows that texture analysis and machine learning may be used to predict pain from T2-weighted images. Thus, a connection between MRI textural features and clinically relevant low back pain may exist. |
| 2656 | Convolutional neural network automatic global segmentation of thigh muscle water-fat images in neuromuscular diseases | |
| Harmen Reyngoudt1,2, Eduard Snezhko3, Pierre-Yves Baudin4, and Pierre G. Carlier1,2 | ||
1NMR Laboratory, Neuromuscular Investigation Center, Institute of Myology, Paris, France, 2NMR Laboratory, CEA/DRF/IBFJ/MIRCen, Paris, France, 3United Institute for Informatics Problems, National Academy of Sciences, Minsk, Belarus, 4Consultants for Research in Imaging and Spectroscopy, Tournai, Belgium |
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Manual segmentation of skeletal muscles in quantitative NMRI studies is a laborious task. In this work, deep learning using a convolutional neural network (CNN) was applied for segmenting the global thigh segment and assessing the muscle fatty replacement over 1 year in patients with several neuromuscular pathologies. A series of 425 Dixon data sets, obtained at 3 T, were used for this purpose. Dice coefficients of 0.97 were obtained when comparing manual and CNN based segmentation. Standardized response means for the fat fraction evolution over 1 year using CNN were at least as high as results obtained with manual segmentation. |
| 2657 | Generalizability of Deep-Learning Segmentation Algorithms on Independent Datasets for Measuring T2 Relaxation Times | |
| Andrew Schmidt1, Arjun D Desai1, Lauren E Watkins2, Hollis Crowder3, Elka Rubin1, Valentina Mazzoli1, Quin Lu4, Marianne S Black1,3, Feliks Kogan1, Garry E Gold1,2, Brian A Hargreaves1,5, and Akshay S Chaudhari1 | ||
1Radiology, Stanford University, Palo Alto, CA, United States, 2Bioengineering, Stanford University, Palo Alto, CA, United States, 3Mechanical Engineering, Stanford University, Palo Alto, CA, United States, 4Philips Healthcare North America, Gainesville, FL, United States, 5Electrical Engineering, Stanford University, Palo Alto, CA, United States |
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Automated segmentation using deep learning can potentially expedite segmentation tasks. However, the generalizability of such algorithms on new unseen datasets is unknown. To test this generalizability, we used a knee segmentation algorithm trained on Osteoarthritis Initiative double-echo steady-state (DESS) datasets to segment cartilage from quantitative DESS datasets from three independent studies. We compared manual-automatic segmentation accuracy and the resultant qDESS T2 map variations. These results quantitatively demonstrate that a deep learning network trained on a single dataset does not generalize with a high accuracy to additional datasets even with similar image characteristics, and that additional fine-tuning may be needed. |
| 2658 | A 3D Convolutional Deep Neural Network for lumbar plexus segmentation | |
| Kevin Bronik1, Marios Yiannakas2, Claudia A. M. Gandini Wheeler-Kingshott3, Daniel Alexander1, and Ferran Prados Carrasco4 | ||
1Center for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, UCL, London, United Kingdom, 2Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, UCL, London, United Kingdom, 3Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, Brain MRI 3T Research Center, IRCCS Mondino Foundation, Pavia, Italy, NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, UCL, London, United Kingdom, 4Universitat Oberta de Catalunya, Barcelona, Spain, Center for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, UCL, London, United Kingdom |
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A fully automated approach for lumbar plexus segmentation that could facilitate quantitative MRI assessments is presented. The approach is based on a 3D cascaded Convolutional Deep Neural Network (CNN) with concatenated loss function and optimized data augmentation policy. The method offers single modality segmentation and uses as input a commonly used 3D acquisition for peripheral nerve imaging. The performance analysis of the predicted segmentation results in comparison to manually segmented masks revealed 68% agreement. Future improvements in the predictive performance of the proposed method are anticipated by involving much larger datasets to reduce overfitting and improve CNN generalization ability. |
| 2659 | External validation of a machine learning algorithm for differentiating between myelodysplastic syndromes and aplastic anemia | |
| Miyuki Takasu1, Takashi Abe2, Shogo Maeda1, Yasutaka Baba1, Yuji Akiyama1, Yuji Takahashi1, Hideaki Kakizawa3, and Kazuo Awai1 | ||
1Department of Diagnostic Radiology, Hiroshima University Hospital, Hiroshima, Japan, 2Department of Radiology, Tokushima University, Tokushima, Japan, 3Department of Radiology, Hiroshima Red Cross Hospital, Hiroshima, Japan |
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An MRI-based predictive model was built to differentiate between myelodysplastic syndrome (MDS) and aplastic anemia (AA). The conventional multiparametric MRI provided correct diagnosis with a support vector machine model at accuracies up to 78.0% with a combination of age, fat fraction, and platelet count. In an external validation, the LeNet model achieved an accuracy of 80.0%, sensitivity of 80.0%, specificity of 81.7%, and AUC of 0.860 for T1WI and an accuracy of 65.6%, sensitivity of 65.6%, specificity of 65.3%, and AUC of 0.667 for STIR images. The machine learning algorithm proved effective for differentiating MDS from AA. |
| 2660 | Mapping of exercise-stimulated muscle perfusion using DCE-MRI and an artificial neural network approach | |
| Jeff L Zhang1, Christopher C Conlin2, Xiaowan Li2, Gwenael Layec3,4, Ken Chang1, Jayashree Kalpathy-Cramer1,5, and Vivian S Lee6 | ||
1A.A. Martinos Center for Biomedical Imaging; Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2Radiology and Imaging Science, University of Utah, Salt Lake City, UT, United States, 3Department of Kinesiology, University of Massachusetts, Amherst, MA, United States, 4Institute for Applied Life Sciences, University of Massachusetts, Amherst, MA, United States, 5MGH and BWH Center for Clinical Data Science, Massachusetts General Hospital, Charlestown, MA, United States, 6Verily Life Sciences, Cambridge, MA, United States |
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We tested the feasibility of using artificial neural network (NN) to rapidly map calf-muscle perfusion, and assessed the importance of data diversity in NN training. Forty-eight DCE MRI data were collected from healthy and diseased subjects stimulated by plantar flexion. Results: the NN method was much faster than model fitting. The NN trained with diverse data gave estimates with mean absolute error (MAE) of 15.9 ml/min/100g, significantly more accurate than regular model fitting or NN trained with homogeneous data (MAE 22.3 and 24.9 ml/min/100g, P<0.001). Conclusion: properly trained NN is capable of estimating muscle perfusion with high accuracy and speed. |
| 2661 | Automated Cartilage Segmentation for Clinical Knee MR Images using Transfer Learning | |
| Mingrui Yang1, Ceylan Colak2, Andreas Nanavati1, Sibaji Gaj1, Carl Winalski2, Naveen Subhas2, and Xiaojuan Li1 | ||
1Program of Advanced Musculoskeletal Imaging, Cleveland Clinic, Cleveland, OH, United States, 2Radiology, Cleveland Clinic, Cleveland, OH, United States |
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Laborious and time-consuming manual or semi-automatic cartilage and meniscus segmentation, which in addition suffers from intra and inter reader variability, has been one of the major hurdles of developing and applying techniques such as quantitative magnetic resonance imaging in routine clinical practice for improved osteoarthritis patient treatment and management plans. In addition, effective and robust deep learning based automatic cartilage and meniscus segmentation models are still lacking in heterogenous clinical settings. The purpose of this study is to assess the feasibility of building an automatic cartilage segmentation model using transfer learning with limited and heterogenous clinical MR scans. |
| 2662 | Noise Reduction of 3D Fast Spin Echo Knee Imaging Using Fusion of Convolutional Neural Networks | |
| Shutian Zhao1, Siyue Li1, Xiaorui Xu1, Chun Ki Franklin Au1, Huimin Zhang1, and Weitian Chen1 | ||
1CUHK lab of AI in radiology (CLAIR), Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong |
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3D FSE can be acquired with isotropic resolution and reformatted into an arbitrary plane for visualizing complex anatomic structures. However, image blurring can occur on short T2 tissues when long echo trains are used. Image deblurring may result in loss of signal-to-noise ratio (SNR). In this work, we proposed a fusion network based on CNNs to address this problem. We demonstrate this network has potential to suppress the noise and reserve structure details at the same time. |
| 2663 | Are Two MR Images Enough to Generate the Third One Accurately? - Clinically Feasible Fat Suppression of Lumbar Spine MRI from T1w and T2w Images Only | |
| Sewon Kim1, Hanbyol Jang1, Kyungwon Kim1, Hyeon Gyu Kim1, Young Han Lee2, Sungjun Kim*2,3, and Dosik Hwang*1 | ||
1Yonsei University, Seoul, Republic of Korea, 2Yonsei University College of Medicine, Seoul, Republic of Korea, 3Gangnam Severance Hospital, Seoul, Republic of Korea |
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This study aims to generate T2-weighted fat suppression (T2 FS) magnetic resonance (MR) lumbar spine image from T1-weighted (T1-w) and T2-weighted (T2-w) images using fully convolutional neural networks. We trained our model that uses multimodal images (T1-w, and T2-w images) to generate synthetic T2FS images close to the acquired T2FS images. The results of our study show that our deep learning model can properly generate bone marrow edema of the vertebral bodies which significantly impact on diagnosis. |
| 2664 | Knee MR Image Translation from Multi Contrast Images for Fat Suppression via Deep Learning with Perceptual Loss | |
| Sewon Kim1, Hanbyol Jang1, Kaustubh Lall2, Armin Jamshidi2, Sheronda Statum2,3, Christine B. Chung2,3, Won C. Bae*2,3, and Dosik Hwang*1 | ||
1Yonsei University, Seoul, Republic of Korea, 2University of California-San Diego, San Diego, CA, United States, 3VA San Diego Healthcare System, San Diego, CA, United States |
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The goal of this study is to generate PD Fat Suppression (PD FS) knee magnetic resonance (MR) image using deep neural network with three multi-contrast MR images (T1-weighted, T2-weighted, PD-weighted images). The results of our study show that our deep learning model can learn the relations between the input multi-contrast images and PD FS image and demonstrate the feasibility of deep learning can generate the features which have an effect on diagnosis. |
| 2665 | Fully Automatic Multi-label Segmentation of Knee joint MRI using Deep Learning Neural Networks | |
| Siyue Li1, Xiaorui Xu1, Chun Ki Franklin Au2, and Weitian Chen1 | ||
1CUHK lab of AI in radiology (CLAIR), Department of imaging and interventional radiology , The Chinese university of Hong Kong, HongKong, Hong Kong, 2Department of imaging and interventional radiology, The Chinese university of Hong Kong, Hong Kong, Hong Kong |
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Accurate segmentation of the cartilage and meniscus is highly desirable for diagnosis and treatment of knee joint diseases. We implemented and compared four deep learning neural networks for fully automated simultaneous segmentation of cartilage and meniscus. Using the Osteoarthritis Initiative (OAI) data sets, we demonstrated the U-net combined with specific post-processing achieved the best performance on femoral cartilage, tibial cartilage, patellar cartilage, and meniscus in terms of dice score. |
| 2666 | Automated Synovitis Segmentation in Patients with Rheumatoid Arthritis | |
| Sibaji Gaj1, Ceylan Colak2, Mingrui Yang1, Kunio Nakamura1, and Xiaojuan Li1 | ||
1Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, United States, 2Department of Radiology, Cleveland Clinic, Cleveland, OH, United States |
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Synovitis is a very common finding in joints of RA patients, which may serve as biomarkers for early diagnosis and for early treatment response evaluation. However, synovitis quantification is challenging because manual segmentation of such irregular lesions is tedious and prone to inter reader variation. In this work, we implemented a fully automatic segmentation algorithm for synovitis lesions in wrist Magnetic Resonance images in subjects with RA using deep learning based conditional generative adversarial networks and U-Net. Using a small number of training data, the proposed model demonstrated feasibility of fully automatically synovitis segmentation with reasonable accuracy (Dice coefficient 0.78). |
| 2667 | Interaction between Modic changes and intervertebral discs revealed using deep learning and attention maps. | |
| Christian Waldenberg1, Hanna Hebelka1, Helena Brisby1, and Kerstin Magdalena Lagerstrand1 | ||
1Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Gothenburg, Sweden |
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Observation of crosstalk between inflammatory IVD and vertebral Modic changes (MCs) has been reported. This study aims to further evaluate possible interaction between MCs and intervertebral discs by utilizing a variety of MR image contrasts and visually displaying the relation using attention maps. The attention maps displayed that both the MC in the vertebra and the surrounding tissue, mainly the intervertebral discs, are important for the classifier. This indicates that there is possible interaction between MC and the surrounding intervertebral discs. The choice of contrast in the images used to train the CNN affected the distribution of the attention maps. |
| 2668 | Deep learning based fully automated screening pipeline for abnormal bone density using a short lumbar Dixon sequence | |
| Shenglan Chen1, Yinxia Zhao2, Xintao Zhang2, Tianyun Zhao1, Mario Serrano-Sosa1, Xiaodong Zhang2, and Chuan Huang1,3,4 | ||
1Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, 2Radiology, The Third Affiliated Hospital of Southern Medical University (Orthopaedic Hospital of Guangdong Province), Guangzhou, China, 3Radiology, Stony Brook Medicine, Stony Brook, NY, United States, 4Psychiatry, Stony Brook Medicine, Stony Brook, NY, United States |
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Bone marrow fat fraction (BMFF) has been recognized as one of the quantitative image biomarkers to identify abnormal bone density using modified Dixon sequence. However, this method requires manual segmentation which limits its adoption in clinical practice. In this study, we developed a fully automated radiomics pipeline using deep learning based segmentation and validated its performance comparable to manual segmentation. This finding will facilitate the clinical utility of the entire pipeline as a screening tool for early detection of abnormal bone density. |
| 2669 | Ultra-Fast Simultaneous T1rho and T2 Mapping Using Deep Learning | |
| Hongyu Li1, Mingrui Yang2, Jeehun Kim2, Ruiying Liu1, Chaoyi Zhang1, Peizhou Huang1, Sunil Kumar Gaire1, Dong Liang3, Xiaojuan Li2, and Leslie Ying1 | ||
1Department of Biomedical Engineering, Department of Electrical Engineering, The State University of New York at Buffalo, Buffalo, NY, United States, 2Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, United States, 3Paul C. Lauterbur Research Center for Biomedical Imaging, Medical AI research center, SIAT, CAS, Shenzhen, China |
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This abstract presents a deep learning method to generate T1rho and T2 relaxation maps simultaneously within one scan. The method uses 3D deep convolutional neural networks to exploit the nonlinear relationship between and within the combined subsampled T1rho and T2-weighted images and the combined T1rho and T2 maps, bypassing conventional fitting models. Compare with separated trained relaxation maps, this new method also exploits the autocorrelation and cross-correlation between subsampled echoes. Experiments show that the proposed method is capable of generating T1rho and T2 maps simultaneously from only 3 subsampled echoes within one scan with quantification results comparable to reference maps. |
| 2670 | Value of texture analysis on the Ktrans map of dynamic contrast enhancement MRI for assessment of critical limb ischemia in diabetic rabbits | |
| Liu Yang1, Yunfei Zha1, and Weiyin Vivian Liu 2 | ||
1Renmin Hospital of Wuhan University, WuHan, China, 2GE Healthcare, Beijing, China |
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Critical limb ischemia (CLI) is a severe complication of diabetes which dramatically increases the risk of limb amputation and mortality. A greater degree of information may be derived by including an assessment of microvascular permeability in proximal femur by the transfer constant (Ktrans) values and MR texture analysis. Twelve diabetic rabbits (6 without CLI, 6 with occluded vasculature of the lower extremities) were examined by dynamic contrast‐enhanced magnetic resonance imaging at fixed time points.We found that Ktrans reached the minimum on one day after ischemia induction, and then recovered along with neoangiogenesis. Three texture features (mean value, MPP, sumAverage) were significantly different between two groups. Ktrans and three TA feature parameters were correlated with capillary density. Overall, Ktrans can be used to quantitative evaluation of changes in femur microvascular permeability in diabetic rabbits with CLI.. Texture analysis can provide more quantification information, which can be more accurately detecting alterations in bone marrow in diabetic rabbits |
| 2671 | Short T2* Components Separation Based on Hyperbolic Tangent R2* Model Using Dual-Echo UTE Imaging | |
| You-Jin Jeong1,2,3, Seung-Nam Baek4,5, Han-Jae Chung1,2,3, Jong-Min Kim1,2,3, Jun-Sik Yoon1,2,3, Chulhyun Lee6, and Chang-Hyun Oh1,2,3,7 | ||
1Electronics and Information Engineering, Korea University, Seoul, Korea, Republic of, 2Korea Artificial Organ Center, Korea University, Seoul, Korea, Republic of, 3ICT Convergence Technology for Health and Safety, Korea University, Sejong, Korea, Republic of, 4Medical Image Engineering, Korea University, Sejong, Korea, Republic of, 5GE Healthcare Korea, Seoul, Korea, Republic of, 6Korea Basic Science Institute, Chungcheongbuk-do, Korea, Republic of, 7Corresponding Author, ohch@korea.ac.kr, Korea, Republic of |
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Ultrashort Echo-Time (UTE) imaging techniques can visualize short T2* components (i.e., bone). Dual-echo UTE imaging was performed with hyperbolic tangent based R2* model to separate the bone and soft tissue. This work demonstrated that cortical bone and bone marrow of skull are well separated with soft tissue using dual-echo UTE images. The proposed method can potentially be used for MR-only transcranial HIFU planning and PET attenuation correction. |
| 2672 | The value of MAVRIC-SL technique in evaluation of unicompartment knee arthroplasty (UKA) at 3.0TMR | |
| Qiang Zhao1 and Lizhi Xie2 | ||
1Radiology Department, Peking University Third Hospital, Beijing, China, 2GE Healthcare, China, Beijing, China |
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MAVRIC-SL is a new metal artifact suppression technology that mitigates this type of aliasing by combining the slice-selectivity of SEMAC with the overlapped excitation and combination properties of MAVRIC. In this study, 24 patients with the unicompartment knee arthroplasty (UKA) were performed MAVRIC-SL and conventional sequence scan at 3.0T MR. The effect of MAVRIC-SL on metal artifact subtraction was analyzed, the results show that MAVRIC-SL can significantly improve image quality and reduce image artifacts compared to conventional 2D-FSE. |
| 2673 | Assessment of infection after joint replacement by MAVRIC-SL MR imaging | |
| Tsutomu Inaoka1, Masayuki Sugeta1, Masahiro Sogawa1, Hisanori Tomobe1, Ryosuke Sakai1, Akinori Yamamoto1, Takamistu Uchi1, Sayuri Kato1, Rumiko Ishikawa1, Tomoya Nakatsuka1, Noriko Kitamura1, Shusuke Kasuya1, and Hitoshi Terada1 | ||
1Radiology, Toho University Sakura Medical Center, Sakura, Japan |
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MAVRIC-SL sequence can improve the quality of images by decreasing metal artifacts and assess infection around prosthetic implants after joint replacement. Presence of intraarticular fluid is important for the diagnosis of infection after joint replacement. The risk of additional surgical intervention due to infection after joint replacement would be higher when there are more than three of the four findings including intraarticular fluid, soft-tissue edema, soft-tissue fluid, and abnormal signal intensity around prosthesis or both intraarticular fluid and abnormal signal intensity around prosthesis. MAVRIC-SL MR imaging must be a powerful tool for the assessment of infection around prosthetic joint implants. |
| 2674 | Diagnostic value of radiomics model based on non-enhanced MR imaging for differentiation of chondrosarcoma from enchondroma | |
| Jielin Pan1, Yunping Jiang1, Wenjuan Li1, Yijie Fang1, Shaolin Li1, and Guobin Hong1 | ||
1the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China |
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Imaging differential diagnosis between Chondrosarcoma and enchondroma is still a challenge because of their similar characteristic. Radiomics1 is a concept that images contain information reflecting underlying pathophysiology and reveal relationship between lesions through quantitative image analyses. Out study aimed to develop radiomics models based on non-enhanced MRI to differentiate chondrosarcoma from enchondroma. Sixty-eight patients were retrospectively studied. The AUC of radiomics model based on TIWI , T2WI-FS were higher than that of conventional MRI (P＜0.01, 0.955, 0.901 and 0.569, respectively). Our preliminary study showed radiomics models can be used in differentiation of chondrosarcoma from enchondroma. |
| 2675 | Short-term repeatability of magnetic resonance fingerprinting for T1 and T2 measurements of metastatic bone lesions in prostate cancer patients | |
| Matthew R Orton1, Mihaela Rata2, Nina Tunariu2, Andra Curcean2, Julie Hughes2, Erica Scurr2, James D'arcy1, Matthew D Blackledge1, and Dow-Mu Koh2 | ||
1Division of Radiotherapy and Imaging, Institute of Cancer Research, Sutton, United Kingdom, 2Department of Radiology, Royal Marsden NHS Foundation Trust, Sutton, United Kingdom |
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Accurate characterisation of bone metastases and their response to treatment remains an unmet need in oncology. Magnetic resonance fingerprinting (MRF) is an imaging technique that yields inherently co-registered quantitative images from a single acquisition, so this work aims to evaluate measurement repeatability of MRF when measuring T1 and T2 relaxation times in metastatic bone disease. We found good measurement repeatability of 6% for lesion mean T1 and 23% for lesion mean T2. |
| 2676 | Survival prediction in patients with osteosarcoma based on MRI Radiomics Features | |
| lu zhang1 | ||
1Henan Provincial People's Hospital, zhengzhou, China |
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The poor 5-year survival rate in high-grade osteosarcoma (HOS) has not been increased significantly over the past 30 years. This work aimed to develop a radiomics nomogram for survival prediction at the time of diagnosis in HOS. |
| 2677 | Preoperative Pathological Differentiation of Grade 1 and Grade 2/3 Soft Tissue Sarcomas based on Radiomics of ADC maps | |
| Yu Zhang1, Shaowu Wang1, Yuwei Xia2, and Kai Zhang1 | ||
1The second hospital of Dalian Medical University, Dalian, China, 2Huiying Medical Technology Inc, Beijing, China |
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Radiomics based on ADC maps provides a new evaluation method for the preoperative pathological differentiation of Grade 1 and Grade 2/3 soft tissue sarcomas. By comparing the performance of five classifiers (random forests, logistic regression, Multi-Layer Perceptron, k-nearest neighbor, and support vector machine), we found that random forests model achieved the best result (AUC: 0.802 (95% CI: 0.659-0.881), sensitivity:0.722, specificity:0.875) on ADC maps, that can serve as a quantitative tool to differentiation of Grade 1 and Grade 2/3 soft tissue sarcomas. And the radiomics features have the capability in reflecting the Ki67 index |
| 2678 | A Comparison study between IVIM-DWI and DCE-MRI derived parameters in rabbit VX2 bone tumor model | |
| Tian Yang1, Changjun Liu1, Xiang Feng2, Mengxiao Liu3, Fu He1, Xiaoli Li1, Ruizhi Zhou1, and Wenjian Xu1 | ||
1Department of Radiology, the Affiliated Hospital of Qingdao University, Qingdao, China, 2MR Scientific Marketing, Siemens Healthcare, Beijing, China, 3MR Scientific Marketing, Siemens Healthcare, Shanghai, China |
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The aim of this study was to evaluate the diagnostic efficiency of the parameters of DCE-MRI and IVIM-DWI between solid area of tumor and normal bone marrow in the model of rabbit VX2 bone tumor. The results showed that DCE-DWI and IVIM-DWI were equally important in the differential diagnosis in the solid area of tumor and normal bone marrow. |
| 2679 | Differentiating ALTs/DDLs from benign lipomas using high-resolution 1H MR Spectroscopy | |
| Santosh K Bharti1, Brett A. Shannon2, Raj Kumar Sharma1, Adam Levin2, Carol Morris2, Laura Fayad2,3, and Zaver M. Bhujwalla1,4,5 | ||
1Div. of Cancer Imaging Research, The Russell H. Morgan Dept of Radiology and Radiological Science, The Johns Hopkins University School of Medicine,, Baltimore, MD, United States, 2Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Musculoskeletal Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 53Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States |
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Adipocytic tumors present a spectrum of neoplastic disease including benign lipomas, atypical lipomatous tumors (ALTs), and malignant liposarcomas DDLs. Distinguishing high-grade liposarcomas (DDLs-dedifferentiated liposarcomas) and premalignant ALTs from benign lipomas can be a diagnostic challenge with implications for surgical and clinical management. Our study demonstrate that high-resolution 1H magnetic resonance spectroscopy (MRS) may be used as an additional method for classification and differential diagnosis of ALTs from benign lipomas. Metabolic analysis clearly reflects the metabolic changes associated with malignant progression. |
| 2680 | A 64-channel receive coil for accelerated diffusion imaging of the upper legs | |
| Susanne S. Rauh1, Melissa T. Hooijmans1, Lars Bannink2, Laura Secondulfo1, Martijn Froeling3, Aart J. Nederveen2, and Gustav J. Strijkers1 | ||
1Department of Biomedical Engineering and Physics, Amsterdam UMC, location AMC, Amsterdam, Netherlands, 2Department of Radiology and Nuclear Medicine, Amsterdam UMC, location AMC, Amsterdam, Netherlands, 3Department of Radiology, Utrecht UMC, Utrecht, Netherlands |
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In elite sports, hamstring injuries are very common and show high recurrence rates. Diffusion tensor imaging is a promising technique to obtain detailed information like return to play time about the injury. Due to the requirement of long scan times and high signal to noise ratio (SNR), a 64-channel upper leg receive coil was developed and compared to a conventional coil in healthy volunteers. Both coils show similar B0 offset and variance. The upper leg coil showed an SNR increase of more than 45% in the biceps femoris long head muscle. This allows for further acceleration of the sequence. |
| 2681 | Evaluation of Kinematics and Image Quality of Thoracic Outlet during Humeral Elevation in Normal Volunteers Using 3D-MRI with Compressed Sensing | |
| Manabu Arai1,2, Taiki Nozaki2, Saya Horiuchi2, Takahiro Sato2, Miki Hirano2, Shigekazu Funada2, Takeshi Hara3, Atsushi Tasaki4, Nobuto Kitamura4, Masahiro Jinzaki1, and Yasuyuki Kurihara2 | ||
1Department of Radiology, Keio University School of Medicine, Tokyo, Japan, 2Department of Radiology, St. Luke's International Hospital, Tokyo, Japan, 3Department of Intelligent Image Information, Gifu University School of Medicine, Gifu, Japan, 4Department of Orthopaedic Surgery, St. Luke's International Hospital, Tokyo, Japan |
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We performed 3D-MR imaging with compressed sensing on the thoracic outlet of 23 normal volunteers, comparing it with conventional 2D-MR imaging. The image quality score of 3D-PDWI with compressed sensing was significantly lower than that of 2D-PDWI. However, no significant difference in the image quality score of MRA with compressed sensing due to arm position was demonstrated. Subclavian arterial stenosis during humeral elevation was shown in 30.4% of asymptomatic subjects without gender predominance. 3D-MR imaging using compressed sensing enables us to evaluate the kinematics of the thoracic outlet, and may contribute to the diagnosis of TOS in clinical settings. |
| 2682 | Validation of a novel 64-channel coil for clinical high-resolution T2-weighted imaging of the upper leg | |
| Lars S. Bannink1,2, Susanne S. Rauh3, Melissa T. Hooijmans3, Robert Hemke1, Frank F. Smithuis1,4, J. Michiel Den Harder1, Josien C. Douw - van den Noort1, Johannes L. Tol4, Frank F.J. Simonis5, Aart J. Nederveen1, Gustav J. Strijkers3, and Mario Maas1,4 | ||
1Department of Radiology and Nuclear Medicine, Amsterdam UMC, location AMC, Amsterdam, Netherlands, 2University of Twente, Enschede, Netherlands, 3Department of Biomedical Engineering and Physics, Amsterdam UMC, location AMC, Amsterdam, Netherlands, 4Academic Center for Evidence-based Sports medicine (ACES), Amsterdam UMC, location, Amsterdam, Netherlands, 5Magnetic Detection and Imaging (MD&I), University of Twente, Enschede, Netherlands |
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Hamstring strains are the most frequent injuries in elite football. Currently, it is not possible to accurately predict recovery or recurrence risk, which motivates the development of improved leg muscle imaging methods and hardware. A novel 64-channel upper leg coil was designed and compared to a conventional coil in healthy volunteers using two clinical high-resolution muscle T2-weighted sequences on 3T. The visibility of the anatomy and image quality were comparable to a conventional coil and scored clinically acceptable by experienced radiologists. The novel coil displayed an increased SNR of 31% which could be exploited to accelerate the imaging protocols. |
| 2683 | Evaluation of Three Different Paradigms for Provoking Blood Oxygenation Level-Dependent MRI Signal Changes in Skeletal Muscles | |
| Shiteng Suo1, Hui Tang1, Qing Lu1, and Jianrong Xu1 | ||
1Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China |
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Stress BOLD MRI allows for quantitative evaluation of blood flow reserve in skeletal muscles. In this study, we conducted a head-to-head comparison between three commonly used stressors including gas inhalation, cuff compression induced ischemia and postocclusive reactive hyperemia, and exercise. Results showed that different paradigms could produce different BOLD signal variation profiles. Both correlation and discrepancy can be noted regarding to the relationship between BOLD MRI and TcPO2 measurements. Ischemia and reactive hyperemia paradigm had better interobserver/interscan reproducibility, exercise had larger signal alterations, and both can reveal the age-dependent differences in BOLD signal and may be preferred in further applications. |
| 2684 | Characterization of the Microenvironment of the Intervertebral Disc in Patients with Chronic Low Back Pain by Z-spectral imaging | |
| Li Li1, Jicheng Fang1, Alessandro Scotti2, Mehran Shaghaghi2, Wenzhen Zhu1, and Kejia Cai2 | ||
1Radiology, Tongji Hospital, Tongji Medical College,HUST, Wuhan, China, Wuhan, China, 2Radiology, 1.Radiology Dept., 2. Bioengineering Dept., College of Medicine, University of Illinois at Chicago, Chicago, IL, United States, Chicago, IL, United States |
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To assess the microenvironment changes of intervertebral disc degeneration, ZSI data were collected from the lumbar spine of 26 patients with CLBP and 21 AC and produced maps of NOE, Water, GAG, APT, MTC. By comparing such parameters between the two groups, it was revealed that the microenvironment of the discs in AC group was different from the discs in the CLBP group. And, the microenvironment of the discs in the sore and non-sore subgroup was also different. ZSI is a noninvasive technique that can be used to test the changes of the microenvironment of the intervertebral discs. |
| 2685 | T2 Analysis of the Entire Osteoarthritis Initiative Dataset (N=25,729) | |
| Alaleh Razmjoo1, Francesco Caliva1, Jinhee Lee1, Felix Liu2, Gabby B. Joseph1, Thomas M. Link 1, Sharmila Majumdar 1,3, and Valentina Pedoia 1,3 | ||
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States, 3Center of Digital Health Innovation (CDHI), University of California, San Francisco, San Francisco, CA, United States |
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Cartilage T2 relaxometry values are previously shown to be correlated to incidence OA, however prognostic ability of T2 is not yet established. In this study, an automatic deep learning method is built using 3921 manually segmented images and T2 was evaluated on entire Osteoarthritis Initiative Dataset (N=25,729). The proposed automatic T2 quantification was shown to be interchangeable with human process and significant association between elevated T2 and future incidence of OA was observed. The results of this study prove the prognostic ability of this compositional MRI technique on the larger sample ever analyzed. |
| 2686 | Optimizing Metal Related Artifact Reduction MRI at 3T: Circular versus Elliptical Radiofrequency Pulse Polarization | |
| Iman Khodarahmi1, John Kirsch2, Gregory Chang1, and Jan Fritz3 | ||
1New York University School of Medicine, New York, NY, United States, 2Massachusetts General Hospital, Boston, MA, United States, 3Johns Hopkins Hospital, Baltimore, MD, United States |
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Clinical metal artifact reduction techniques address B0 inhomogeneity-induced artifacts; whereas other source of artifacts, such as B1 inhomogeneity remain unaddressed. However, B1 inhomogeneity can be reduced by implementing an elliptical polarization of the radiofrequency pulse. In an in-vitro setup of hip arthroplasty implants, we show that MRI with elliptical pulse polarization results in stronger metal artifact reduction and overall superior image quality than circular polarization without increase in SAR values. |
| 2687 | Short T2* quantification of knee structures based on accelerated UTE Spiral VIBE MRI with SPIRiT reconstruction | |
| Céline Smekens1, Floris Vanhevel2, Ben Jeurissen3, Pieter Van Dyck2, Jan Sijbers3, and Thomas Janssens1 | ||
1Siemens Healthcare NV/SA, Beersel, Belgium, 2Department of Radiology, Antwerp University Hospital and University of Antwerp, Edegem, Belgium, 3imec-Vision Lab, Department of Physics, University of Antwerp, Wilrijk, Belgium |
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Clinical validation of quantitative UTE MRI techniques in musculoskeletal studies remains limited, despite their potential to unveil short T2* information. As these techniques require considerably more scan time than conventional imaging, there is a need for integration of acceleration methods. This study investigated the use of the UTE Spiral VIBE sequence with in-plane acceleration and SPIRiT reconstruction for short T2* mapping of knee structures. As similar image quality and T2* values were obtained for the non-accelerated and accelerated acquisitions, the UTE Spiral VIBE technique shows great promise for fast UTE T2* MRI of the knee. |
| 2688 | Ideal Weighting Parameter for Non-Contrast Detection of Synovitis Using Diffusion-Weighted DESS | |
| Jacob Thoenen1, James W MacKay2, Akshay Chaudhari1, Lauren E Watkins1, Emily McWalter3, Brian Hargreaves1, Feliks Kogan1, and Garry E Gold1 | ||
1Radiology, Stanford University, Stanford, CA, United States, 2Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 3Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada |
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Non-contrast diffusion-weighted double echo steady state (DESS) imaging has been proposed as an alternative to T1-weighted contrast-enhanced MRI for the evaluation of synovitis. We investigated various weighting values (β) for hybrid image creation from the weighted difference between echos of the DESS sequence in order to null joint fluid and enhance visualization of the synovium. We found that the extended phase graph (EPG) model provided the best β for low diffusion weighted DESS and fluid ROI mean suppression (FRMS) provided the best β for high diffusion DESS. Both methods showed potential for non-contrast evaluation of synovitis for routine knee scanning. |
| 2689 | Whole Body Composition in Patients Living with HIV | |
| Ravi Chachad1, Gabby B Joseph1, Jiamin Zhou1, Phyllis Tien2,3, Thomas M Link1, Galateia Kazakia1, and Roland Krug1 | ||
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Department of Medicine, University of California San Francisco, San Francisco, CA, United States, 3Department of Veterans Affairs, University of California San Francisco, San Francisco, CA, United States |
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HIV infection is associated with loss of subcutaneous adipose tissue, and the initiation of effective antiretroviral therapy has been associated with increased visceral adipose tissue (VAT). To quantify these changes in the body, MRI was used to image and conduct whole-body composition analysis. VAT was significantly higher in men with HIV infection than control males; there was little difference in females. In general, VAT ratio, the ratio of VAT to subcutaneous adipose tissue, was higher in patients living with HIV (PLWH) than controls. MRI is a quick, radiation-free alternative to DXA and CT in measuring whole-body composition in PLWH. |
| 2690 | Accelerated high-resolution (0.5mm2) T1ρ mapping of the knee joint using interleaved spin-lock-prepared 3D gradient echo with Compressed SENSE | |
| Keita Nagawa1, Suzuki Masashi1, Masami Yoneyama2, Kaiji Inoue1, Eito Kozawa1, and Mamoru Niitsu1 | ||
1Saitama Medical University, Saitama, Japan, 2Philips Japan, Tokyo, Japan |
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3D T1ρ mapping sequence allows rapid acquisition of the entire volume data of each anatomic region, including major joint tissues. In this work, we propose the accelerated high-resolution 3D T1ρ-mapping of the knee-joint using motion-robust interleaved spin-lock acquisition with Compressed SENSE. We compared the T1p mapping with in-plane resolution of 0.5mm2 with different C-SENSE reduction factors (3 and 4.2). There are no clear differences between two image datasets, hence we applied C-SENSE reduction factor of 4.2 (5min48s) for clinical scans, acquiring motion-insensitive high-quality isotropic images less than 6 minutes. |
| 2691 | Classification of annular fissures and pain-positive discograms using multiple MRI-features with Machine Learning | |
| Kerstin Lagerstrand1,2, Hanna Hebelka1,3, Leif Thorén1,3, Christian Waldenberg1,2, and Helena Brisby1,4 | ||
1Institute of Clinical Sciences, Gothenburg University, Gothenburg, Sweden, 2Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden, 3Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden, 4Orthopaedics, Sahlgrenska University Hospital, Gothenburg, Sweden |
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Imaging-based features are needed to improve the characterization of degenerative IVD-changes and possibility of finding a linkage between features and pain. Multiple T2w-imaging-features and Machine-Learning was used for classification of fissures involving outer annulus and for pain-positive discograms. Fissures were classified with high accuracy/precision using regional/heterogeneity features with/without axial loading of the spine. For pain-positive discograms, a larger number of such MRI-features contributed to the classification. Findings suggest that multiple MRI-features, extracted from T2w-imaging, improve the classifications, and that regional/heterogeneity features extracted with both conventional imaging with the spine unloaded and with axial loading of the spine are of importance. |
| 2692 | Discovering MRI Imaging Biomarkers Associated with Progression of Knee Pain Using Deep Learning for Survival Analysis | |
| Jinhee Jenny Lee1, Chul Young Chung2, Felix Liu3, Sharmila Majumdar1, and Valentina Pedoia1 | ||
1Department of Radiology and Biomedical Engineering, UCSF, San Francisco, CA, United States, 2Bay Imaging Consultants, Walnut Creek, CA, United States, 3Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA, United States |
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Medical attention for knee osteoarthritis (OA) is currently focused on symptomatic pain management in clinical setting. Associating future knee OA pain development with baseline characteristics of knee OA cohort is important in understanding of disease prognosis and designing treatment strategies. We built a predictive model of knee OA pain-free survival time using baseline MRI and other image-independent clinical measurements. |
| 2693 | PSEUDO-CT IMAGE GENERATION FROM MULTIPLE ECHO TIME 7 TESLA MR DATA VIA GAUSSIAN MIXTURE MODELLING | |
| Shaeez Usman Abdulla1, David Reutens1, and Viktor Vegh1 | ||
1University of Queensland, Brisbane, Australia |
||
With the increasing introduction of new PET-MR systems, MRI-based methods for pseudo-CT image generation for PET attenuation correction have to be made widely applicable. Existing methods requiring prior anatomical information for estimating CT values form MR signals have been shown to perform poorly, especially in patients. Ultrashort echo time (UTE) MR data has shown some promise, as it is sensitive to tissue classes captured in CT images. We applied existing MR-based methods and a new Gaussian mixture model approach relying on multi-echo MR magnitude and phase data for pseudo-CT image generation. The Gaussian mixture modelling method outperformed other methods investigated. |
| 2694 | Dynamic Contrast Enhanced MR Imaging of Synovitis: Repeatability, Discriminative Validity and Responsiveness in Knee Osteoarthritis | |
| James MacKay1,2, Faezeh Sanaei Nehad3, Josh Kaggie2, Jo Naish3, Caleb Roberts3, Martin Graves2, Fiona Gilbert2, Andrew McCaskie4, John Waterton3,5, Rob Janiczek6, Alexandra Roberts6, and Geoff Parker3 | ||
1Radiology, University of East Anglia, Norwich, United Kingdom, 2Radiology, University of Cambridge, Cambridge, United Kingdom, 3BiOxyDyn Ltd, Manchester, United Kingdom, 4Surgery, University of Cambridge, Cambridge, United Kingdom, 5Informatics, Imaging & Data Sciences, University of Manchester, Manchester, United Kingdom, 6Clinical Imaging, GlaxoSmithKline, Stevenage, United Kingdom |
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Synovitis is common in knee osteoarthritis (OA) and can be quantified using dynamic contrast-enhanced MR imaging (DCE-MRI). There is a strong rationale for therapeutic targeting of synovitis in OA, and imaging biomarkers derived from DCE-MRI may help evaluate response in clinical trials. Here we evaluate the test-retest repeatability, ability to discriminate between OA (n = 14) and age-matched controls (n = 6) and 6-month responsiveness to change of three DCE-MRI biomarkers: Ktrans, IAUC60, and synovial tissue volume. Ktrans demonstrated the best repeatability, discrimination and sensitivity to change suggesting that it is the optimal DCE-MRI biomarker for use in clinical trials. |
| 2695 | Myoelectric Triggered Diffusion-Weighted Imaging for Muscle Contraction Analysis | |
| Martin Schwartz1,2, Petros Martirosian1, Günter Steidle1, Michael Erb3, Bin Yang2, and Fritz Schick1 | ||
1Section on Experimental Radiology, University Hospital of Tuebingen, Tuebingen, Germany, 2Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany, 3Biomedical Magnetic Resonance, University Hospital of Tuebingen, Tuebingen, Germany |
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Retrospective measurements of muscular contraction in diffusion-weighted imaging are inherently asynchronous leading to an unknown time point of acquisition during the muscular motion. Therefore, prospective imaging is investigated based on surface electromyography signals derived during the measurement. Fast and more robust real-time activity detection is achieved by a neural network. Imaging during active muscular contraction can be prevented by analysis of the muscular state; however, sampling at different time points of the muscular contractions is also possible. |
| 2696 | IVIM MRI evaluation of blood flow response to exercise in patients with low back pain compared to healthy, pain-free controls | |
| Erin K Englund1, David B Berry2, John J Behun1, Lawrence R Frank3, Samuel R Ward1,3,4, and Bahar Shahidi1 | ||
1Orthopaedic Surgery, University of California San Diego, La Jolla, CA, United States, 2Nanoengineering, University of California San Diego, La Jolla, CA, United States, 3Radiology, University of California San Diego, La Jolla, CA, United States, 4Bioengineering, University of California San Diego, La Jolla, CA, United States |
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IVIM MRI was used to evaluate changes in muscle blood flow before and after lumbar extension exercise in patients with low back pain and healthy controls. Results showed that IVIM was sensitive to blood flow changes from exercise in both groups. Pain free controls had a higher mean diffusion coefficient (D) and the change in D from exercise was also greater in this cohort. A subset of patients with low back pain who had a limited response to exercise per the pseudo-diffusion coefficient (D*) were also found to have no improvement in disability following a 12-week physical therapy regimen. |
| 2697 | Comparison of simulated and experimental stimulated echo diffusion at varying diffusion times in skeletal muscle | |
| Erin K Englund1, David B Berry2, Vitaly Galinsky3, Lawrence R Frank3, and Samuel R Ward1,3,4 | ||
1Orthopaedic Surgery, University of California San Diego, La Jolla, CA, United States, 2Nanoengineering, University of California San Diego, La Jolla, CA, United States, 3Radiology, University of California San Diego, La Jolla, CA, United States, 4Bioengineering, University of California San Diego, La Jolla, CA, United States |
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Diffusion tensor imaging provides insight into the underlying tissue microstructure. Here, we compare simulated DTI data to experimentally acquired data in skeletal muscle using stimulated echo DTI at multiple diffusion encoding times. After adjusting for the difference in simulated versus measured apparent diffusion coefficient, there was relative agreement of mean diffusivity and radial diffusivity between the measured and simulated data. Fractional anisotropy was overestimated experimentally, likely due to limited image SNR. |
| 2698 | Evaluating Longitudinal Muscle Degeneration in ALS Patients using MR Cytography | |
| Sudarshan Ragunathan1, Laura C Bell1, Ashley M Stokes1, Natenael Semmineh1, Jessie Duncan2, Nicole Turcotte2, Shafeeq Ladha2, and Chad C Quarles1 | ||
1Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2Gregory W. Fulton ALS and Neuromuscular Center, Barrow Neurological Institute, Phoenix, AZ, United States |
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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by loss of upper and lower motor neurons (UMN and LMN), resulting in muscle atrophy and eventual death. Clinical indicators such as ALSFRS-R scores can be confounded by inter-rater variability and low sensitivity. MR Cytography based TRATE has been shown to identify changes to myofiber microstructure. This work aims to demonstrate that TRATE is a more sensitive and consistent metric to evaluate longitudinal muscle degeneration in ALS patients than existing clinical indicators such as ALSFRS-R scores. |
| 2699 | Stiffness change of the rotator cuff muscle before and after the tendon tear with magnetic resonance elastography and ultrasound elastography. | |
| Akihisa Koga1, Yoshiaki Itoigawa1, Mikio Suga2, Yuri Suganuma3, Tomoki Wada1, Daichi Morikawa1, Yuichiro Maruyama1, and Kazuo Kaneko4 | ||
1Orthopaedic surgery, Juntendo Urayasu Hospital, Chiba, Japan, 2Center for Frontier Medical Engineering, Chiba University, Chiba, Japan, 3Graduate School of Science and Engineering, Chiba University, Chiba, Japan, 4Orthopaedic surgery, Juntendo University, Tokyo, Japan |
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The purpose of this study was to explore the feasibility of Magnetic Resonance Elastography (MRE) measurement for quantification of the stiffness change of the shoulder rotator cuff muscle compared with Shear Wave ultrasound Elastography (SWE). Six porcine shoulders were used in this study. MRE and SWE measurement of the rotator cuff muscle was performed before and after the rotator cuff tendon detachment. Stiffness values were significantly lower after the tendon detachment in both MRE and SWE measurements (p<0.05). This result suggests that MRE could be a feasible method for quantification of the rotator cuff muscle stiffness as well as SWE. |
| 2700 | Compressed sensing three-directional 3D velocity imaging of the skeletal muscle during evoked isometric contraction of the arm | |
| Xeni Deligianni1,2, Francesco Santini1,2, Anna Hirschmann3, Ning Jin4, Nicolas Place5, Oliver Bieri1,2, and Claudia Weidensteiner1,2 | ||
1Radiology/Division of Radiological Physics, University Hospital of Basel, Basel, Switzerland, 2Biomedical Engineering, University of Basel, Basel, Switzerland, 3Radiology, University Hospital of Basel, Basel, Switzerland, 4Siemens Medical Solutions, Cleveland, Cleveland, OH, United States, 5Institute of Sport Sciences, University of Lausanne, Lausanne, Switzerland |
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MRI of the upper extremities is important for the follow-up of muscle dystrophies. The goal of this study was to investigate the feasibility of 4D-velocity imaging during neuromuscular electrical stimulation(NMES) of the arm, standardized with the force output. Two healthy volunteers were scanned at 3T during isometric contraction of the biceps brachii for different elbow angles. While the force output was different in intensity, the waveforms of force and strain were similar. In conclusion, it was shown that it is possible to acquire 3D-dynamic velocity data synchronized with NMES of the arm and simultaneously record the evoked force. |
| 2701 | Diffusion tensor imaging of calf muscle damage in peripheral arterial disease | |
| Jianli Wang1, Jonathan Stavres2, Christopher T Sica1, Cheryl Blaha2, Michael Herr2, Samuel Pai2, Aimee Cauffman2, Jeffrey Vesek3, Qing X Yang1,4, and Lawrence I Sinoway2 | ||
1Radiology, Penn State College of Medicine, Hershey, PA, United States, 2Heart & Vascular Institute, Penn State College of Medicine, Hershey, PA, United States, 3Molecular Biology, Penn State College of Medicine, Hershey, PA, United States, 4Neurosurgery, Penn State College of Medicine, Hershey, PA, United States |
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Peripheral arterial disease (PAD) is a systemic atherosclerotic vascular disease characterized by impaired skeletal muscle perfusion and mitochondrial respiration. Over time, persistent exposure to muscle ischemia eventually leads to muscle atrophy, myopathy, and mitochondrial dysfunction in PAD patients. In this study we investigated the utilization of diffusion tensor imaging to characterize the pathophysiological changes of calf muscles before and after graded plantar flexion exercise. At rest, the clinically worse leg of the PAD subjects had higher diffusivity in the calf muscles. Significant greater increases of diffusivity in the post-exercise muscle of PADs than the HCs suggest acute exercise-related muscle damage. |
| 2702 | Comparison of measurements of intramuscular fat from T1-weighted and mDixon MRI scans in people with and without spinal cord injury | |
| Bart Bolsterlee1,2, Elizabeth A Bye3,4, Junya Eguchi1,5, Joanne Glinsky3, Jeanette Thom5, and Robert D Herbert1,5 | ||
1Neuroscience Research Australia, Randwick, Australia, 2Graduate School of Biomedical Engineering, University of New South Wales, Randwick, Australia, 3John Walsh Centre for Rehabilitation Research, Sydney University, Sydney, Australia, 4Spinal Injury Unit, Prince of Wales Hospital, Randwick, Australia, 5School of Medical Sciences, University of New South Wales, Randwick, Australia |
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Accurate quantification of fat content of human muscles could help assess disease status and test effectiveness of interventions in people with neurological conditions, whose muscles are frequently infiltrated with fat. We compared two commonly used MRI methods based on T1-weighted and mDixon scans to quantify intramuscular fat in 112 muscles from people with and without spinal cord injury. Fat fraction measurements agreed well in muscles with high proportions of fat, but the T1-weighted method could not be used in muscles with small proportions of fat. We recommend against the use of T1-weighted methods to quantify intramuscular fat. |
| 2703
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The Molecular Basis for 31P MRS-Based Phosphocreatine Muscle Resynthesis Rate Measurements in Healthy Adults | |
| Maninder Singh1, Moses M Darpolor2, Jeffrey Covington1, Sebastian Hanet1, Eric Ravussin1, and Owen T Carmichael1 | ||
1Pennington Biomedical Research Center, Baton Rouge, LA, United States, 2Stillman College, Tuscaloosa, AL, United States |
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Dynamic phosphorus magnetic resonance spectroscopy (31P-MRS) is a method used for in vivo studies of skeletal muscle function including measurements of phosphocreatine (PCr) synthesis rate during recovery from submaximal exercise. However, the molecular events underlying the PCr resynthesis rate are still under debate. Therefore, our goal was to assess the PCr resynthesis rate from 31P-MRS spectra collected from the skeletal muscle (vastus lateralis) of healthy adults and investigate associations between PCr resynthesis and levels of mitochondria-related transcripts and proteins in the same muscle (NAMPT, NQO1, PGC-1α, and SIRT1). |
| 2704 | The visualization technique of the distribution of muscle quality by sport characteristics / changes due to growth using q-space imaging | |
| Daisuke Nakashima1, Junichi Hata2, Yasushi Sera1, Hirotaka James Okano2, Kazuki Sato1, Takeo Nagura1, Hideyuki Okano1, Morio Matsumoto1, and Masaya Nakamura1 | ||
1Keio University School of Medicine, Tokyo, Japan, 2Jikei University School of Medicine, Tokyo, Japan |
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We evaluated the muscle quality of lower limbs among four groups: controls, marathon players, powerlifters, and teenagers using q-space imaging. Initially, we confirmed that fast muscle fiber has a larger cell size than slow muscle fiber in cadaveric immunohistology study of the tibialis anterior muscle (TA). In addition, there were many fast muscle fiber in the TA. In q-space imaging study, the cell diameter increased in the process of growing up from teenage to adulthood, which indicates an increase in fast muscle cells according to growth. Furthermore, the powerlifting players had more enlarged fast muscle cells than other groups. |
| 2705 | 31P MRS assessments of mitochondrial dysfunction in patients with peripheral arterial disease undergoing revascularization. | |
| Jabrane Karkouri1,2,3, Jill Slade4, Helene Ratiney1, Sylvain Grange1, Anne Tonson4, Pierre Croisille1, and Magalie Viallon1 | ||
1Université de Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, Lyon, France, Lyon, France, 2SIemens Healthcare SAS, Saint-Denis, France, 3Wolfson Brain Imaging Center, University of Cambridge, Cambridge, United Kingdom, 4Radiology, Michigan state university, East Lansing, MI, United States |
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Obliterative arterial disease of the lower limbs is a disease that obstructs lower extremities arteries, resulting in reduced lower limb perfusion and possibly mitochondrial dysfunction. Mitochondrial function of the calf assessed via 31P MRS at moderate and low exercise intensities before and after revascularization and phase contrast angiography of the posterior tibial artery enabled the assessment of vascular and mitochondrial contributions of the patients. |
| 2706 | Detecting motor unit activity during volitional muscle contraction – Motor Unit MRI | |
| Linda Heskamp1, Matthew G. Birkbeck1,2,3, Ian S. Schofield4, Roger G. Whittaker4, and Andrew M. Blamire1 | ||
1Newcastle Magnetic Resonance Center, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 2Northern Medical Physics and Clinical Engineering, Freeman Hospital, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, 3Newcastle Biomedical Research Centre (BRC) NIHR, Newcastle University, Newcastle upon Tyne, United Kingdom, 4Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom |
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Motor units (MUs) play a fundamental role in muscle physiology and disease. They can be imaged using a diffusion weighted imaging technique, motor unit MRI (MUMRI). Previous work activated MUs using electrical stimulation, limiting MUMRI to muscles innervated from superficial nerves. Here, we demonstrated the feasibility of MUMRI during volitional muscle activation. We confirmed that the MU activity detected with MUMRI during muscle contraction increased with b-value, force level and was dependent on the diffusion-sensitisation direction. This work allows us to image MUs in situations reflecting real muscle physiology making it a promising tool for studying motor neuron diseases. |
| 2707 | Variability of Diffusion Tensor MRI, 2-Point Dixon fat fraction and T2 relaxation in ROIs of thigh muscle in rheumatoid arthritis patients | |
| Dominic Bertham1,2, Matthew Farrow3, Ai Lyn Tan3, Steven Tanner1, Paul Emery3, and John Biglands1 | ||
1Leeds Biomedical Research Centre, Leeds, United Kingdom, 2Department of Health Sciences, University of York, York, United Kingdom, 3Leeds institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom |
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Muscular weakness is associated with fatty infiltration and changes to muscle fibre structure. Quantitative magnetic resonance imaging (MRI) may be able to detect subtle muscle changes in rheumatoid arthritis (RA) patients. Before this method is used, variability of MRI measurements involving regions of interest (ROI) must first be measured. Fat fraction, T2 measurement and diffusion tensor imaging was performed on 19 participants with RA. Intra-rater and inter-rater variability of MRI measurements for thigh muscle ROIs were assessed. Inter-rater and intra-rater variability scores were high, suggesting that these measurements are sufficiently precise to allow the study of subtle changes to muscle. |
| 2708 | Detecting Muscle Activity using a 0.5T Upright Open MRI – A Pilot Study Using a Double Echo Steady State Sequence to Measure T2 in Biceps and Triceps | |
| Noor Shaikh1,2,3, Andrew Yung4, Honglin Zhang5, John Street2,6, Cornelia Laule2,7,8,9, Thomas Oxland2,3,6, and David Wilson2,5,6 | ||
1Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, 2ICORD, University of British Columbia, Vancouver, BC, Canada, 3Mechanical Engineering, University of British Columbia, Vancouver, BC, Canada, 4UBC MRI Research Center, University of British Columbia, Vancouver, BC, Canada, 5Centre for Hip Health and Mobility, University of British Columbia, Vancouver, BC, Canada, 6Orthopaedics, University of British Columbia, Vancouver, BC, Canada, 7Radiology, University of British Columbia, Vancouver, BC, Canada, 8Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 9Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada |
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We used a 0.5T upright open MRI to investigate T2 as a marker for muscle activity. Six volunteers’ arms were imaged with a Double Echo Steady State (DESS) sequence while relaxing (30min), following weighted bicep curls, and again after relaxing (20min). Directly after bicep curls T2 increased (average 41%) in the biceps but not the triceps, then subsequently decreased (average 14%) with relaxing. Intra-rater repeatability was promising. T2 standard deviation was relatively high, which is likely due to tissue heterogeneity. This preliminary study supports the potential of using DESS in upright open MRI to assess muscle injury or dysfunction. |
| 2709 | Assessment of peripheral muscle deconditioning using 31P-MRS during high intensity ischaemic plantar flexion exercise | |
| Jordan McGing1, Rosemary Nicholas1, Sebastien Serres2, Paul Greenhaff2, Gordon Moran3, and Susan Francis1 | ||
1Sir Peter Mansfield Imaging Centre, Nottingham, United Kingdom, 2University of Nottingham, Nottingham, United Kingdom, 3Nottingham Digestive Diseases Centre, Nottingham, United Kingdom |
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Non-invasive assessment of muscle quality is of relevance in chronic disease, where muscle deconditioning is prevalent. To quantify PCr kinetics, localised and non-localised 31P acquisitions were performed during ischemic plantar flexion exercise and recovery. Application of non-localised 31P acquisition resolved motion induced phasing issues and low temporal resolution apparent in 31P ISIS data acquisitions. This allowed quantitation of PCr kinetics in response to high intensity ischemic exercise, successfully providing a surrogate marker of muscle quality in fatigued CD patients. Application of this within-bore exercise protocol to fatigued CD patients and healthy control volunteers will provide insight into pathological fatigue mechanisms. |
| 2710 | The effect of ageing on skeletal muscle as assessed by quantitative MR imaging: an association with frailty and muscle strength | |
| Matt Farrow1, John Biglands1, Steven F Tanner1, Elizabeth Hensor1, Philip O'Connor1, Paul Emery1, and Ai Lyn Tan1 | ||
1University of Leeds, Leeds, United Kingdom |
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The proportion of older people in the population is increasing. It is known that muscle health deteriorates with age, resulting in a loss of muscle mass and strength, known as sarcopenia. This study demonstrates that ageing is associated with a significant increase in fat fraction and T2 and a significant decrease in muscle volume, grip strength and muscle power. Quantitative MRI parameters correlated with frailty index, grip strength and muscle power. Therefore, quantitative MRI measurements have the potential to be useful markers of age and muscle health and can be used in the management and treatment of sarcopenia and frailty. |
| 2711 | Is fractal dimension value of the lumbar multifidus muscle associated with low back pain? | |
| Junchao Ma1, Nan Yu1, Ruifeng Wang1, and Shaoyu Wang2 | ||
1The Affiliated Hospital of Shaanxi University of Chinese Medicine, Xian Yang, China, 2MR Scientific Marketing Specialist Diagnostic Imaging Healthcare Greater China, Xi'an, China |
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Magnetic resonance imaging (MRI) is considered the best imaging method to evaluate the multifidus degeneration. The existing evaluation methods based on fat infiltration fraction (FSF) cannot fully reflect the muscle integrity and functional status. In order to obtain a tool for objective and continuous grading of multifidus degeneration. Fractal method was used to analyze the signal heterogeneity of multifidus. The fractal dimension of lumbar multifidus muscle（LMM） is closely related to LBP. The fractal dimension may be a reliable imaging marker for monitoring the degree of multifidus degeneration in symptomatic patients. |
| 2712 | Quantification of Fat Fraction in Muscles Adjacent to Lumbosacral Plexus within Healthy People Using IDEAL-IQ Sequence | |
| Mengyue Wang1, Yin Shi1, Weiqiang Dou2, and Yuefen Zou1 | ||
1Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2GE Healthcare, MR Research China, Beijing, China |
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Many diseases can result in increased fatty infiltrations within muscles adjacent to lumbosacral plexus. However, the normal level of fat content in paraneural muscles is not clear within healthy people. In this study, we applied iterative decomposition of water and fat with echo asymmetry and least-squares estimation intelligent quantification (IDEAL-IQ) to measure fat fraction (FF) of paraneural muscles within healthy participants. We found that FF values of paraneural muscles in healthy people depend on gender and age. Therefore, both factors of gender and age need to be taken into account, when assessing the FF levels of muscles in diseases. |
| 2713 | Muscle Diffusion tensor imaging shows changes in non-fat infiltrated muscles in late-onset Pompe disease (LOPD) | |
| Lara Schlaffke1, Martijn Froeling2, Marlena Rohm1, Johannes Forsting1, Martin Tegenthoff1, Matthias Vorgerd1, and Robert Rehmann1 | ||
1Neurology, BG UK Bergmannsheil, Bochum, Germany, 2Radiology, UMC Utrecht, Utrecht, Netherlands |
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Quantitative MRI-markers are essential for monitoring disease progression in late-onset pompe disease (LOPD). Using muscle diffusion tensor imaging (mDTI) and mDixon we evaluated differences in diffusion parameters in six thigh and seven calf muscles - with <10% and >10% fat-fraction - of 18 LOPD and 29 healthy controls (HC). Upper leg muscles with <10% fat-fraction showed significant differences in MD, RD, λ1-3 and MD positively correlated with 6-MWT (p=0.003). mDTI reveals an increased diffusion restriction in muscles of LOPD-patients with and without fat-infiltration and could reflect structural changes prior to fatty degeneration. |
| 2714 | Evaluation of Interrater comparability of manual and tractography based thigh muscle segmentation of diffusion tensor images | |
| Lara Schlaffke1, Robert Rehmann1, Martijn Froeling2, and Johannes Forsting1 | ||
1Neurology, BG UK Bergmannsheil, Bochum, Germany, 2Radiology, UMC Utrecht, Utrecht, Netherlands |
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Muscle diffusion tensor imaging is a quantitative magnetic resonance image (MRI) technique, which can provide information about muscular microstructure and integrity. Due to high intermuscular variability, the manual separation of the muscles is essential. Here, we have compared three methods, which allow assessing of diffusion properties of the thigh muscles. In each of the three investigated methods, two independent raters performed the muscle segmentation. We could show, that volume-based tractography proved to be the most reliable and robust method (ICC = 0.923-0.985) and has the advantage to achieve additional information about muscle architecture. |
| 2715 | A method for quantification of changes in leg muscle fiber orientations | |
| Laura Secondulfo1, Joep J M Suskens2, Ozgur Kilic2, Valentina Mazzoli3, Mario Maas4, Hans J.L Tol2, Aart Nederveen4, Melissa Hooijmans1, and Gustav J Strijkers1 | ||
1Biomedical Engineering and Physics, UMC Amsterdam, Location AMC, Amsterdam, Netherlands, 2Orthopedic Surgery, UMC Amsterdam, Location AMC, Amsterdam, Netherlands, 3Radiology, Lucas Center for Imaging, Stanford University, Stanford, CA, United States, 4Radiology and Nuclear Medicine, UMC, Amsterdam, Location AMC, Amsterdam, Netherlands |
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Hamstring injuries have high recurrence rates in elite athletes, which motivates the investigations in novel diagnostic methods for muscle injury and follow-up. Diffusion tensor imaging facilitates direct and indirect monitoring of the muscle condition and architecture. Fiber orientations and changes therein due to injury or training are considered a key parameter; however, the assessment over the full volume of an individual muscle is still difficult. Therefore, we developed a method to generate reproducible quantitative fiber-angle color maps of the whole volume of leg muscles, which proved sensitive to changes due to muscle stretch and a training intervention. |
| 2716 | A novel approach for 3D whole muscle strain measurements during isometric muscle contractions | |
| Melissa Tamara Hooijmans1,2, Crystal L. Coolbaugh1, Hannah L. Kilpatrick1, Mark K George1, and Bruce M Damon1,3 | ||
1Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 2Department of Biomedical Engineering & Physics, Amsterdam University Medical Centers, Amsterdam, Netherlands, 3Department of Radiology and Radiological Sciences, Biomedical Engineering, and Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, United States |
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In this study we explore the feasibility of using displacement fields to quantify whole muscle 3D strain patterns during submaximal voluntary contractions of the dorsiflexor muscles. Our results showed a consistent pattern, of large negative (shortening) and a large positive (lengthening) principal strains. Both the magnitude and pattern of strain agree with other studies performed during submaximal contractions which indicates the feasibility of this approach to quantify 3D strain. |
| 2717 | Parametric Maps of Creatine Recovery Constants in Exercised Muscle | |
| Dushyant Kumar1, Deepa Thakuri1, Blake Benyard1, Hari Hariharan1, Ravi Prakash Reddy Nanga1, and Ravinder Reddy1 | ||
1Radiology, University of Pennsylvania, Philadelphia, PA, United States |
||
Though oldest noninvasive imaging biomarker for creatine kinase (CK) reaction in exercised muscle, phosphorous magnetic resonance spectroscopy (31PMRS) suffers from the poor resolution. The 2D creatine Chemical Exchange Saturation Transfer allows for the assessment of creatine recovery with excellent in plane spatial resolution, it was not possible to construct voxel wise parametric maps for recovery time constant due to low signal to noise ratio (SNR). Recently developed 3D implementation of CrCEST allowed for higher SNR and increased volumetric coverage and we exploit these two advantages in our novel non-local spatially regularized approach to reconstruct parametric map for recovery time constant. |
| 2718 | Metabolic Imaging of Skeletal Muscle in Aging Rats: Potential for improving muscle metabolism with Rapamycin | |
| Rengaraj Anantharaj1, Jadegoud Yaligar1, Giang Thi Thu Le1, Venkatesh Gopalan1, Sanjay Kumar Verma1, Kavita Kaur1, Kasthuri Thirumurugan2, Johan G Eriksson2,3, Brian Kennedy4, and S Sendhil Velan1,2 | ||
1Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, A*STAR, Singapore, Singapore, 2Singapore Institute for Clinical Sciences, A*STAR, Singapore, Singapore, 3Department of Obstetrics & Gynecology, National University of Singapore, Singapore, Singapore, 4Center for Healthy Aging, National University of Singapore, Singapore, Singapore |
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Aging associated loss of muscle mass leads to metabolic diseases and compromised quality of life. Increase in intramyocellular lipid (IMCL) and reduced skeletal muscle mass are associated with insulin resistance and diabetes. Rapamycin increases muscle mass by inhibiting the mTOR signalling pathway. In this study, we investigated IMCL metabolism and muscle mass in response to rapamycin intervention in an aging rodent model. We observed significant reduction in IMCL along with increase in muscle mass indicating improved muscle metabolism with rapamycin intervention. Muscle differentiation gene, MyoD was upregulated and myostatin which is negative regulator of muscle growth factor was down regulated. |
| 2719 | Measuring Spontaneous Muscular Activities in Neuromuscular Disease: Preliminary Results | |
| Martin Schwartz1,2, Petros Martirosian1, Günter Steidle1, Thomas Küstner1,2,3, Bin Yang2, Alto Stemmer4, Thorsten Feiweier4, Ludger Schöls5,6, Matthis Synofzik5,6, and Fritz Schick1 | ||
1Section on Experimental Radiology, University Hospital of Tuebingen, Tuebingen, Germany, 2Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany, 3School of Biomedical Engineering & Imaging Sciences, King's College London, St. Thomas' Hospital, London, United Kingdom, 4Siemens Healthcare GmbH, Erlangen, Germany, 5Department Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Tübingen & Center for Neurology, Tuebingen, Germany, 6German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany |
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Quantification of spontaneous mechanical activities in musculature like fibrillations or fasciculations is of high interest for the assessment of neuro-muscular function in normal and impaired subjects. The diagnostic assessment of neuromuscular disease focuses at specific muscular regions, and the measurement protocol was optimized in order to robustly quantify spontaneous activities in these areas. This work shows preliminary results regarding activity patterns of healthy and diseased subjects. |
| 2720 | Differences between inflammatory and dystrophic myopathies revealed by the multi-exponential behavior of water-T2 decays in skeletal muscle | |
| Ericky Caldas de Almeida Araujo1,2, Harmen Reyngoudt1,2, and Pierre G. Carlier1,2 | ||
1NMR Laboratory, Neuromuscular Investigation Center, Institute of Myology, Paris, France, 2NMR Laboratory, CEA/DRF/IBFJ/MIRCen, Paris, France |
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Although sensitive to disease activity, the mono-exponential muscle water T2 is non-specific to the underlying dominant pathophysiological processes taking place in the different neuromuscular disorders. In this work we performed multi-exponential analysis of muscle water T2-relaxation data acquired in healthy subjects, Duchenne Muscular Dystrophy and Inclusion Body Myositis patients. T2-decay curves were obtained using 1H NMR spectra acquired at different echo times. The results put in evidence a distinct water T2-relaxation behavior between inflammatory and dystrophic myopathies, supporting the hypothesis that a multi-exponential analysis of T2-relaxation data can reveal specific pathophysiological information that is missing from mono-exponential analysis. |
| 2721 | Quantitative MRI of muscles is different in rheumatoid arthritis patients compared to healthy controls | |
| Matt Farrow1, John Biglands1, Steven F Tanner1, Elizabeth Hensor1, Paul Emery1, and Ai Lyn Tan1 | ||
1University of Leeds, Leeds, United Kingdom |
||
Rheumatoid arthritis can present with the loss of muscle mass and a decrease in strength and functional capability. This study demonstrates that Quantitative MRI can detect differences in the muscles of RA patients, whether they are newly diagnosed, in remission or with persistently active disease. Differences in T2, FF and muscle volume were apparent at diagnosis, suggesting muscle changes in RA occur early. Furthermore, despite RA treatment, patients in remission show worse MRI parameters and strength compared to healthy individuals, suggesting the muscles have pathology. This warrants attention in improving the muscle health throughout the spectrum of the RA continuum. |
| 2722 | Short T2 Fraction Mapping of Skeletal Muscle Integrating Ultralow TE (UTE) and MP-IDEAL multiecho data | |
| Usha Sinha1, Vadim Malis2, Edward Smitaman3, and Shantanu Sinha3 | ||
1Physics, San Diego State University, San Diego, CA, United States, 2Physics, UC San Diego, La Jolla, CA, United States, 3Radiology, UC San Diego, La Jolla, CA, United States |
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Ultralow TE imaging of skeletal muscle enables the visualization of low T2* species. In skeletal muscle, the signal from the small fraction of short-T2 (T2S) components are masked by the larger component long-T2 (T2L) species. One method is to extract the short T2 components from subtracted images of a dual echo UTE sequence. However, the subtracted images invariably have residual signal from lipids due to the chemically shifted frequencies of signals produced by lipids. We integrate the fat fraction and T2L extracted from MP-IDEAL sequence to the subtracted UTE images to extract the fibrosis fraction. |
| 2723 | Monitoring micro-dystrophin treatment effects in mdx4cv mice using magnetic resonance imaging and spectroscopy | |
| Ravneet Vohra1, Guy Odom2, Jeffrey S Chamberlain2,3,4, and Donghoon Lee1 | ||
1Radiology, University of Washington, Seattle, WA, United States, 2Neurology, University of Washington, Seattle, WA, United States, 3Medicine, University of Washington, Seattle, WA, United States, 4Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, University of Washington, Seattle, WA, United States |
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Mutations in the X-linked dystrophin gene disrupts protein expression resulting in Duchenne muscular dystrophy (DMD), a neuromuscular disorder characterized by body-wide muscle cell degeneration. The mdx mouse model is one of the most commonly used animal models for DMD. Recombinant adeno-associated viral (rAAV) vector-mediated gene transfer represents a promising approach for DMD. Magnetic resonance has emerged as a noninvasive method in monitoring disease progression and treatment response for muscular dystrophy. The aim of this study was to elucidate the functional impact of micro-dystrophin on skeletal muscles using magnetic resonance imaging and spectroscopy. |
| 2724 | CrCEST effects in Knee Osteoarthritis Patients following Plantar Flexion Exercise of lower leg skeletal muscle at 7.0T | |
| Deepa Thakuri1, Dushyant Kumar1, Abigail Cember1, Ravi Prakash Reddy Nanga1, Lizbeth Novelo2, Hari Hariharan1, Joshua Baker2, and Ravinder Reddy1 | ||
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Rheumatology & Epidemiology, University of Pennsylvania, Philadelphia, PA, United States |
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Osteoarthritis (OA) is the leading cause of disability in adult and aging populations. Knee OA increases difficulty in the functional use of various upper and lower leg muscles. In the recent years, CrCEST technique has emerged as a potential imaging biomarker to study muscle metabolism and its application was shown in different systemic diseases like mitochondrial disorders. Here, we are particularly interested in exploring and investigating the correlation of knee OA with post exercise CrCEST increase. |
| 2725 | Association between Abdominal Fat and Skeletal Muscle Tissues Fat Deposition in Type 2 Diabetes Mellitus: A Pilot Investigation | |
| Manoj Kumar Sarma1, Andres Saucedo1, Daniel Kohanghadosh1, Kavya Umachandran1, Ely R. Felker1, Christine H. Darwin2, and M. Albert Thomas1 | ||
1Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 2Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States |
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Increased intramyocellular and extramyocellular lipids (IMCL and EMCL), abdominal lipids and decreased lipid unsaturation ratios, are of prime interest in determining relationships of these changes to insulin sensitivity and progression to type 2 diabetes (T2DM). We acquired 6-point Dixon based MRI of abdomen and accelerated MR Spectroscopic Imaging in calf muscle. In the T2DM group, BMI correlated positively with visceral fat, total fat and hepatic fat fractions. In contrast, BMI correlated negatively with pancreatic fat fractions (body/tail) in age-matched healthy volunteers. Mostly association between IMCL unsaturation index and abdominal fat content was observed. Also, we found an excellent correlation between abdominal lipid accretion and calf muscle lipid infiltration in T2DM and healthy controls predominantly inside muscle fibers (IMCL). |
| 2726 | Longitudinal Analysis of Knee Articular Cartilage in Collegiate Basketball Players and Swimmers: Preliminary Results | |
| Elka B Rubin1, Valentina Mazzoli1, Marianne Black1, Arjun D Desai1, Kate Young1, Feliks Kogan1, Ashwin Sreedhar1, Dominic J Vincentini1, Katelin A Knox1, Tomoo Yamada1, Andrew McCabe2, Marc Safran1, Sharmila Majumdar3, Hollis G Potter4, and Garry E Gold1 | ||
1Stanford University, Stanford, CA, United States, 2Santa Clara University, Santa Clara, CA, United States, 3University of California San Francisco, San Francisco, CA, United States, 4Hospital for Special Surgery, New York, NY, United States |
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Basketball players place high loads on their knee joints that can lead to chronic knee injuries. In this study, we used advanced MRI methods and a cluster analysis to longitudinally study cartilage structure and potential early degenerative changes in Division 1 (D1) basketball players and swimmers. Pre-season and post-season quantitative results indicate an increase in T2 and T1p relaxation times in the central compartment of the femoral cartilage in the basketball players compared to the swimmers. The results of this study suggest that microstructural changes in knee cartilage can occur in one season of D1 college play. |
| 2727 | Diffusion tensor imaging of articular cartilage at 3T: repeatability and sensitivity to degenerative changes | |
| Valentina Mazzoli1, Lauren Elizabeth Watkins1, Elka Brooke Rubin1, Brian Hargreaves1, Feliks Kogan1, and Garry Evan Gold1 | ||
1Department of Radiology, Stanford University, Stanford, CA, United States |
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Mean Diffusivity (MD) and Fractional Anisotropy (FA) derived from DTI are a very promising biomarker of cartilage health. Many current implementations of DTI require high field scanners, and its feasibility utility at 3T is unclear. The aim of this study was to develop an optimized DTI acquisition and postprocessing protocol for the evaluation of femoral articular cartilage at 3T in a clinically feasible scan time, and to assess its repeatability and sensitivity to transient changes induced by exercise. Our results show that MD and FA measurements at 3T are repeatable and robust to changes induced by exercise. |
| 2728 | Short Term Effects of Running on Knee Cartilage: Global and Regional T2 Relaxation Times in Femoral Cartilage of Female Recreational Runners | |
| Hollis Crowder1, Valentina Mazzoli2, Marianne Black2, Lauren Watkins3, Feliks Kogan2, Brian Hargreaves4, Marc Levenston4, and Garry Gold4 | ||
1Mechanical Engineering, Stanford University, Palo Alto, CA, United States, 2Radiology, Stanford University, Palo Alto, CA, United States, 3Bioengineering, Stanford University, Palo Alto, CA, United States, 4Stanford University, Palo Alto, CA, United States |
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To identify potential changes in cartilage hydration or microstructure resulting from exercise we compared global and regional T2 relaxation times of eleven female recreational runners and five controls at baseline, time 0, and time 60 minutes post-exercise. No significant difference in mean T2 relaxation times between the runner group and the control group were found at any time point in either global or regional analysis. Suspected changes in cartilage hydration or microstructure resulting from biomechanical running forces may not manifest in such a way that is detectable by global or regional T2 relaxation analysis compared to controls. |
| 2729 | Robust Statistics for T1ρ-Mapping of Knee Cartilage on Mono- and Bi-Exponential Models: Optimal Spin-Lock Times and Fitting Methods | |
| Marcelo Victor Wust Zibetti1, Azadeh Sharafi1, and Ravinder Regatte1 | ||
1Radiology, NYU, New York, NY, United States |
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T1ρ-mapping using mono- or bi-exponential models usually require multiple spin-lock times (#TSLs). Choosing the optimal #TSLs for improved SNR, i.e. minimizing the Cramer-Rao lower bound (CRLB), is important. However, Gaussian statistics with CRLB usually lead to the repetition of longer TSLs and the minimum number of shorter TSLs. This choice is non-robust to large data acquisition errors caused by subject motion or other scan related problems that strongly affect quantitative parameters. To alleviate this problem, we propose a robust T1ρ-protocol based on optimized #TSLs using CRLB with robust statistics, and outlier-robust fitting method. |
| 2730 | Scan-Rescan Variability and Left-Right Knee Asymmetry of Cartilage Morphometry Assessed with Rapid MRI in a Harmonized Multi-Vendor Study | |
| Akshay Chaudhari1, Quin Lu2, Anna Wisser3,4, Wolfgang Wirth3,4, Garry E Gold1, Brian A Hargreaves1, and Felix Eckstein3,4 | ||
1Stanford University, Stanford, CA, United States, 2Philips, San Francisco, CA, United States, 3Paracelsus Medical University, Salzburg, Austria, 4Chondrometrics GmbH, Ainring, Germany |
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Changes in cartilage morphology have shown to predict and monitor osteoarthritis progression with great sensitivity. However, the lack of a rapid and inexpensive MRI technique for imaging cartilage that can be implemented across vendors is a challenge in large multi-site clinical studies. In this work, we evaluate multi-vendor and scan-rescan reliability and explore left-right knee asymmetries of cartilage morphology measured using a rapid, 4-minute quantitative double-echo steady-state (qDESS) sequence. We demonstrate qDESS harmonization across vendors, which can produce high scan-rescan repeatability and high repeatability of left-right knee asymmetry of cartilage volume, surface area, and thickness metrics. |
| 2731 | Detecting Early Changes in ACL-Reconstructed Knee Cartilage Using Diffusion-Weighted MRI | |
| Halston J.C. Sandford1, Marianne Black2,3, Akshay S. Chaudhari2, Arjun Desai2,4, Feliks Kogan1, Brian A. Hargreaves2,4,5, Garry E. Gold2,5,6, and Valentina Mazzoli2 | ||
1Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States, 3Mechanical Engineering, Stanford University, Stanford, CA, United States, 4Electrical Engineering, Stanford University, Stanford, CA, United States, 5Bioengineering, Stanford University, Stanford, CA, United States, 6Orthopedic Surgery, Stanford University, Stanford, CA, United States |
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ACL-injured individuals, despite reconstructive surgery, have an increased risk of developing osteoarthritis and methods to identify early changes in cartilage are needed to allow implementation of treatment. Diffusion-weighted MRI (DWI) has been shown to provide information on femoral cartilage health. This study aims to assess the potential of DWI to detect early degenerative changes in articular cartilage following ACL reconstruction. We found that DWI shows elevated ADC values in both ACL-injured and contralateral knees compared with controls at baseline. DWI did not show significant changes in cartilage over time within 18 months of post-ACL-reconstructive surgery. |
| 2732 | Functional Gradient Indices for the Early Detection and Prediction of Osteoarthritis: Data from Human Explants and the OAI Database | |
| Robert L. Wilson1, Nancy C. Emery2, David M. Pierce3,4, and Corey P. Neu1 | ||
1Mechanical Engineering, University of Colorado Boulder, Boulder, CO, United States, 2Ecology and Evolutionary Biology, University of Colorado Boulder, Boulder, CO, United States, 3Mechanical Engineering, University of Connecticut, Storrs, CT, United States, 4Biomedical Engineering, University of Connecticut, Storrs, CT, United States |
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Spatial gradients in articular cartilage structure trend toward homogeneity with onset and progression of osteoarthritis (OA). Exploiting MRI, we compared heterogeneous variations in tissue structure, and the corresponding function, to OA severity through the use of spatial first derivatives, herein termed functional gradient indices (FGIs), providing new biomarkers indicating tissue state. We evaluated FGI maps of MRI data visualizing osteochondral human explants and OAI subjects for relationships to OA severity. FGI data correlated significantly with tissue health, while traditional metrics did not. The sensitivity and versatility of FGI analysis suggests a novel biomarker with improved detection of early disease pathogenesis. |
| 2733 | Application of Compressed Sensing to Quantitative Double Echo steady state (qDESS) for Rapid T2 Relaxometry in Knees | |
| Quin Lu1, Brian A Hargreaves2, and Akshay S Chaudhari2 | ||
1Clinical Science, Philips Healthcare NA, San Francisco, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States |
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Quantitative Double Echo Steady State (qDESS) is a fast 3D MRI sequence capable of simultaneous knee morphometry and T2 relaxometry. Compressed-sensing based acceleration methods are more and more readily available from major MRI vendors, and have the potential to further speed up qDESS and to provide greater clinical value. In this study, we investigate the feasibility of applying Philips Compressed SENSE (CS) to qDESS. We show that CS does not bias the T2 accuracy of qDESS. Our findings support the clinical application of CS accelerated qDESS for fast and quantitative MR knee assessment. |
| 2734 | MP2RAGE improves robustness of 3D T1-Mapping of Hip Cartilage compared to Conventional Dual-Flip-Angle Acquisition | |
| Bernd A Jung1, Onur Afacan2, Till Lerch1, Young-Jo Kim3, Tobias Kober4,5,6, Michael Ith1, Markus Klarhoefer7, and Florian Schmaranzer1 | ||
1Diagnostic, Interventional and Pediatric Radiology, University Hospital Bern, Bern, Switzerland, 2Dept of Radiology, Boston Children`s Hospital, Boston, MA, United States, 3Dept of Orthopaedic Surgery, Boston Children`s Hospital, Boston, MA, United States, 4Advanced Clinical Imaging Technology, Siemens Healthcare, Lausanne, Switzerland, 5Dept of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 6LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 7Siemens Healthcare, Zuerich, Switzerland |
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Although commonly used for T1 mapping of hip cartilage, 3D dual flip angle (DFA) techniques are sensitive to flip angle variations related to B1 inhomogeneities. Therefore, the IR-based MP2RAGE technique was compared with a standard 3D DFA acquisition including B1 field mapping for T1 mapping of hip cartilage in a phantom study and in healthy volunteers at 3T. For the phantom study, a 2D IR-based sequence was additionally acquired to provide reference T1 maps. MP2RAGE resulted in more accurate T1 values with less regional variations compared to DFA method and therefore enables a more robust T1 mapping of hip cartilage. |
| 2735 | To Evaluate the Effect of Normalization on Femur Cartilage T2 Values in Diagnosis of Osteoarthritis | |
| Rafeek Thaha1, Sandeep Panwar Jogi1,2, Sriram Rajan3, Amit Mehndiratta1,4, Anup Singh1,4, and Dharmesh Singh1 | ||
1Centre for Biomedical Engineering, Indian Institute of Technology, New Delhi, India, 2Biomedical Engineering, ASET, Amity University Haryana, Gurgaon, India, 3Mahajan Imaging Centre, New Delhi, India, 4Department of Biomedical Engineering, All India Institute of Medical Sciences, New Delhi, India |
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Quantitative MR parameters(such as T2-relaxation time) are sensitive to biochemical changes in the cartilage. The objective of the study was to evaluate the performance of different statistics parameters from T2 values of femur cartilage and normalized T2 map (Z-score T2 map) values for differentiating healthy vs OA patients as well as Early-OA (Grade-I and Grade-II), vs Risk-OA (Grade-III) patients. Multiple Statistic parameter from T2 map provided high accuracy in differentiation between healthy vs OA cartilage, while one of the static parameter of Z-score T2 map provided high accuracy in differentiation between early-OA vs Risk-OA. |
| 2736 | A self-compensated spin-locking scheme for quantitative R1ρ dispersion in articular cartilage | |
| YUXI PANG1 | ||
1Department of Radiology, University of Michigan, Ann Arbor, MI, United States |
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A self-compensated spin-locking (SL) scheme for quantitative R1ρ dispersion in cartilage has been developed. The performance of this new method was evaluated by Bloch simulations and R1ρ dispersion (with 6 SL RF strengths ranging from 50 to 1000 Hz) studies on agarose (1-4%, w/v) phantom and on one healthy human knee in vivo at 3T, with respect to three reported SL approaches. The simulated and experimental results indicate that the proposed SL method was less susceptible to B0 and B1 field artifacts for a wide range of SL strengths, and thus more suitable for quantitative R1ρ dispersion in ordered tissue. |
| 2737 | qDESS ADC as a Biomarker for Early Degeneration in Femoral Cartilage of Post-Reconstruction ACL Tear Patients and Correlation with DWI-EPI ADC | |
| Mary Elizabeth Hall1,2, Valentina Mazzoli2, Marianne Black1,2, Halston Sandford2, Katherine Young2, Daehyun Yoon2, Bragi Sveinsson3, Akshay Chaudhari2, Emily McWalter4, Feliks Kogan2, Marc Levenston1,2,5, Brian Hargreaves2,5,6, and Garry Gold2 | ||
1Mechanical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States, 3Massachusetts General Hospital, Boston, MA, United States, 4Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, 5Bioengineering, Stanford University, Stanford, CA, United States, 6Electrical Engineering, Stanford University, Stanford, CA, United States |
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This study evaluates apparent diffusion coefficient (ADC) as measured by a quantitative double echo steady state (qDESS) sequence as a biomarker for early osteoarthritis detection in articular cartilage in the femur and its correlation with ADC from a diffusion weighted echo planar (DWI-EPI) scan. 9 injured knees and contralateral knees of patients undergoing reconstruction surgery following anterior cruciate ligament tears were scanned with qDESS and DWI-EPI sequences up to 18 months post surgery. There were no consistent patterns of qDESS ADC change on a global or regional basis in the femoral cartilage. qDESS ADC did not correlate with DWI-EPI ADC. |
| 2738 | Detecting Early Changes in ACL-Reconstructed Knees: Cluster Analysis of T2 Relaxation Times from 3 Months to 18 Months Post-Surgery | |
| Marianne S Black1,2, Katherine A Young1, Akshay S Chaudhari1, Feliks Kogan1, Bragi Sveinsson3, Emily J McWalter4, Garry E Gold1,5, Marc E Levenston1,2, and Brian A Hargreaves1,5,6 | ||
1Radiology, Stanford University, Stanford, CA, United States, 2Mechanical Engineering, Stanford University, Stanford, CA, United States, 3Massachusetts General Hospital, Boston, MA, United States, 4Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, 5Bioengineering, Stanford University, Stanford, CA, United States, 6Electrical Engineering, Stanford University, Stanford, CA, United States |
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There is a need to detect and quantify early osteoarthritic changes for the development of treatments for osteoarthritis progression. ACL-injured subjects are at an increased risk of developing osteoarthritis, and T2 is sensitive to the structure and composition of cartilage, including osteoarthritic change. This study used a quantitative DESS acquisition to obtain T2 maps in 10 subjects 3-weeks, 3-months, 9-months, and 18-months after ACL reconstruction surgery and 10 controls at matched times. Our results show that T2 cluster analysis was able to detect changes to the ACL-reconstructed cartilage as early as 3-months post-surgery and these differences persisted at 18-months. |
| 2739 | Multiparametric MRI Predicts Articular Cartilage Proteoglycan Content and Collagen Fiber Orientation | |
| Abdul Wahed Kajabi1,2, Seyed Amir Mirmojarabian1,2, Juuso Ketola1, Timo Liimatainen1,2, Miika T. Nieminen1,2,3, Mikko J. Nissi4, and Victor Casula1,2 | ||
1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 2Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, 3Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland, 4Department of Applied Physics, University of Eastern Finland, Kuopio, Finland |
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In this study, multiparametric MRI was used to predict cartilage proteoglycan content and collagen fiber orientation, as measured by quantitative microscopy. Twenty osteochondral samples were obtained from stifle joints of ten Shetland ponies. Measurements of 14 different MRI parameters, including T1, T2, continuous wave T1rho, adiabatic T1rho and T2rho, and TRAFF were performed at 9.4 T. Three ensemble-based regression models (Gradient Boosting, Random Forest and Extra Trees) were used and the highest coefficients of determination (r2) were 0.77 for collagen orientation and 0.62 for proteoglycan content. These findings show that multiparametric MRI can be used to non-invasively estimate cartilage histology. |
| 2740 | Site-Specific Quantitative µMRI and Polarized Light Microscopy (PLM) Study of Young Rabbit Femur Cartilage | |
| Yang Xia1, Syeda Batool1, and Mohammad Hammimi1 | ||
1Physics, Oakland University, Rochester, MI, United States |
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This work aims to characterize the site-specific and depth dependent molecular and morphological structures in young rabbit femur cartilage, using quantitative µMRI (T2 relaxation) and Polarized light microscopy (PLM). |
| 2741 | Assessment of short-term and mid-term knee cartilage changes before and after marathon running using T2* mapping images | |
| Xiaoshuai Chen1, Ranxu Zhang1, Xiaoyue Zhou2, Esther Raithel3, and Jian Zhao1 | ||
1The third Hospital of Hebei Medical University, Shijiazhuang, China, 2Siemens Healthineers Ltd, Shanghai, China, 3Siemens Healthcare, Erlangen, Germany |
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Once articular cartilage is damaged it cannot be readily repaired. However, to what extent marathon running causes cartilage damage to the knees is unclear. We quantitatively assessed the morphologic and T2* value changes in the knee cartilage of marathon runners using an automatic cartilage segmentation method. The cartilage volume, thickness, and T2* values of 21 sub-regions were quantitatively assessed. The results showed that the T2* value of knee cartilage increased right after running and recovered two months later, suggesting that the knee joint cartilage showed a degree of reversible change after marathon running. |
| 2742 | Quantification of knee cartilage using automated cartilage segmentation prototype software : Clinical validation on volunteers | |
| Ping Zhang1, Xiao Yue Zhou2, Esther Raithel3, Xu Ran Zhang4, Xiao Shuai Chen4, Jian Ling Cui4, and Jian Zhao4 | ||
1The third Hospital of Hebei Medical University, Shijiazhuang, China, 2MR Collaboration, Siemens Healthineers Ltd,Shanghai,China, ShangHai, China, 3Siemens Healthcare, Erlangen, Germany., Erlangen, Germany, 4radiology, The third Hospital of Hebei Medical University, Shijiazhuang, China |
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Manual cartilage segmentation is a time-consuming post-processing procedure, especially for clinical doctors. Automatic cartilage segmentation frees doctors from tedious computer work. Although there have been various automatic segmentation algorithms, accurate automatic segmentation is still a challenge. In this study, we validated the automatic cartilage segmentation results of the knee joint using a 3D high-resolution DESS sequence. We found that the location of cartilage subregions, and the hydrarthrosis and cartilage degeneration may influence the accuracy of the segmentation. In order to derive more accurate results, a manual finetuning of the automatic segmentation was done. Automatic segmentation still saved considerable time. |
| 2743 | Distinguishing Exercise-Induced Compositional Changes in Knee Cartilage with Quantitative MR Relaxation Time Mapping | |
| Dimitri A Kessler1, Joshua D Kaggie1, James W MacKay1,2, Scott McDonald3, Andrew Grainger1, Alexandra R Roberts4, Robert L Janiczek5, Martin J Graves1, and Fiona J Gilbert1 | ||
1Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 2Norwich Medical School, University of East Anglia, Norwich, United Kingdom, 3Cambridge University Hospitals NHS Foundation Trust, Addenbrooke’s Hospital, Cambridge, United Kingdom, 4Independent Clinical Imaging Consultant, Munich, Germany, 5GlaxoSmithKline, Clinical Imaging, Philadelphia, PA, United States |
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We introduce a method to reliably determine changes in healthy knee cartilage composition after joint loading. Ten healthy participants were imaged before and after participant repositioning to determine the test-retest repeatability of T1ρ and T2 relaxation time mapping. Additionally, nine healthy participants were imaged before and after a mild, dynamic stepping exercise. Three-dimensional surface analysis of patellar, femoral, and lateral and medial tibial cartilage was performed. The exercise surface data was thresholded with the determined measurement errors from the T1ρ and T2 repeatability data to highlight cartilage regions experiencing reliable exercise-induced compositional changes. |
| 2744 | Accelerating 3D-T1ρ cartilage imaging using signal compensated low-rank plus sparse matrix decomposition | |
| Yuanyuan Liu1,2, Weitian Chen3, Xin Liu1, Hairong Zheng1, Dong Liang1,2, and Yanjie Zhu1 | ||
1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Research center for Medical AI, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 3Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China |
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The quantitative 3D-T1ρ mapping requires multiple T1ρ-weighted images with different spin lock times (TSLs) to obtain the T1ρ map, which makes the acquisition time very long. In this work, a signal compensation strategy with low-rank plus sparse model (SCOPE) was used to reconstruct T1ρ-weighted images from highly undersampled data. We provide the reconstructed images and the estimated T1ρ maps at an acceleration factor up to 8.5 in fast 3D-T1ρ cartilage imaging. |
| 2745 | Accelerated T1ρ Acquisition for Knee Cartilage Using Compressed Sensing：Quantitative evaluation | |
| Ye Li1, Guangbin Wang1, Weibo Chen2, and Aocai Yang1 | ||
1Shandong Medical Imaging Research Institute,Shandong University, Jinan, China, 2Philips Healthcare, Shanghai, China |
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The current work evaluates the influence of compressed sensing accelerated imaging on the T1ρ mapping. Quantitative evaluation is done using quantitative T1ρ mapping for knee cartilage quantification. T1ρ quantification after CS-accelerated acquisition was compared with non-CS-accelerated acquisition for central patella cartilage. |
| 2746 | Improving DESS contrast in 7T hip images using L1-norm denoising and optimal echo combination | |
| Aurelien Destruel1, Mingyan Li 1, Craig Engstrom2, Ewald Weber1, Jin Jin1,3,4, Rahel Heule5, Oliver Bieri6, Feng Liu1, and Stuart Crozier1 | ||
1School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia, 2School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia, 3University of Southern California, Los Angeles, CA, United States, 4Siemens Healthcare Pty Ltd, Brisbane, Australia, 5High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 6Division of Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland |
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The double-echo steady-state (DESS) sequence has been used successfully in 3T MRI imaging of the musculoskeletal system for segmentation of joint. However, in 3D-DESS images acquired at 7T MRI, a reduction in the contrast between tissues due to an increased diffusion sensitivity may complicate cartilage segmentation. Typically, the signals acquired with DESS are averaged without any pre-processing. However, these signals give different contrasts and have different noise behaviours. In this work, we improve the contrast-to-noise ratio (CNR) whilst preserving anatomical detail in high-resolution 7T DESS images through a new approach combining L1-norm denoising and p-norm combination of the echo signals. |
| 2747 | Comparison between high-resolution DESS images of the hip joint at 3T and 7T MRI | |
| Aurelien Destruel1, Mingyan Li 1, Ewald Weber1, Jin Jin1,2,3, Shekhar S Chandra1, Jurgen Fripp4, Feng Liu1, Stuart Crozier1, and Craig Engstrom5 | ||
1School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia, 2Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, 3ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, Brisbane, Australia, 4CSIRO Health and Biosecurity, Herston, Australia, 5School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia |
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Advances in automatic segmentation of cartilage in hip joints has shown the need for high resolution and contrast in 3D sequences. In this work, double-echo steady-state (DESS) hip images from a healthy volunteer were compared at 3T and 7T. 3D-DESS with a resolution up to 0.4x0.4x0.6mm3 was acquired, and showed that the 7T images had superior anatomical detail, signal-to-noise ratio (SNR), contrast ratio (CR) and overall image quality. The improvements observed in 7T imaging of the hip have the potential to boost the performance of automated cartilage segmentation algorithms by reducing segmentation errors. |
| 2748 | T2 Relaxation Time Reveals Improvement of Articular Cartilage Quality After Bariatric Surgery at 12-month Follow-up | |
| Sami Lehtovirta1,2, Ahti Kemppainen1,2, Marianne Haapea2,3, Jaro Karppinen2,4,5, Eveliina Lammentausta2,3, Vesa Koivukangas6, Eero Kyllönen7, Mika Nevalainen1,2,3, Anna-Maija Kauppila7, Victor Casula1,2, and Miika T. Nieminen1,2,3 | ||
1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 2Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, 3Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland, 4Center for Life Course Health Research, University of Oulu, Oulu, Finland, 5Finnish Institute of Occupational Health, Oulu, Finland, 6Department of Surgery, Oulu University Hospital, Oulu, Finland, 7Department of Physical Medicine and Rehabilitation, Oulu University Hospital, Oulu, Finland |
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Obesity has become a worldwide phenomenon with nearly tripling since 1975: 13% of adults over 18 are obese. We set out to study articular cartilage of knee joint in obese individuals using T2 relaxation time. Our study population underwent Roux-en-Y gastric bypass operation and were compared with a control group of obese individuals in a 12-month follow-up. Our results suggest improved quality of cartilage in the lateral compartment of femoral cartilage after bariatric surgery. |
| 2749 | Inhomogenous Magnetization Transfer Imaging in Cartilage – Initial Demonstration and Protocol Optimization at 7 Tesla | |
| Andrew C. Yung1, Valentin H. Prevost1, Jane Desrochers2, David Wilson2, and Piotr Kozlowski1 | ||
1UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 2Centre for Hip Health and Mobility, University of British Columbia, Vancouver, BC, Canada |
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This work presents one of the first examples of ihMT imaging in cartilage, using ex vivo bovine knee specimens at 7 Tesla. Protocol optimization experiments were performed to determine the optimal set of parameters (B1rms, TR, frequency offset, centre frequency) to maximize the ihMTRex signal. Cartilage-specific signal was observed, which may be related to residual dipolar order established by the highly ordered nature of collagen. |
| 2750 | Magnetization Transfer Techniques (MTR and ihMTRex) for Detecting Cartilage Strain in Loaded ex vivo Joints at 7 Tesla | |
| Andrew C Yung1, Valentin H. Prevost1, Jane Desrochers2, Emily Sullivan2, Piotr Kozlowski1, and David Wilson2 | ||
1UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 2Centre for Hip Health and Mobility, University of British Columbia, Vancouver, BC, Canada |
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We investigated the use of magnetization transfer ratio MTR and ihMTRex as a potential surrogate of cartilage strain, using ex vivo cow knee specimens in a uniaxial compression rig. On MTR and ihMTRex image volumes for several load levels, the cartilage strain and average MTR or ihMTRex for each column of pixels within the cartilage were calculated. Normalized change in MTR showed a linear relation with strain throughout the tested range of deformation, whereas ihMTRex only showed response at the highest load levels. These techniques may be an attractive alternative to T2 or T1ρ techniques to map cartilage strain. |
| 2751 | Tibial Rotation and Knee Flexion Moment Correlate to Patellofemoral Deep Cartilage UTE-T2* 2 Years After ACL Reconstruction | |
| Ashley A Williams1,2, Jennifer Erhart-Hledik1,2, Jessica L. Asay2,3, Gordhan Mahtani1,2, and Constance R. Chu1,2 | ||
1Orthopaedic Surgery, Stanford University, Stanford, CA, United States, 2Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States, 3Mechanical Engineering, Stanford University, Stanford, CA, United States |
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Patellofemoral joint osteoarthritis (PFOA) following anterior cruciate ligament reconstruction (ACLR) is thought to arise, in part, due to increased external rotation of the tibia and decreased quadriceps strength that alter the tracking of the patella in the trochlear groove. In this study of 59 subjects 2 years after ACLR, higher cartilage UTE-T2* values were detected in ACLR knees with greater external tibial rotations and greater knee flexion moments assessed by gait analysis. This study provides evidence that UTE-T2* is sensitive to patellofemoral cartilage degeneration likely due to altered patellar tracking and quadriceps strength in knees at risk of PFOA. |
| 2752 | Prospective clinical validation of 3D MP2RAGE for T1 mapping of hip cartilage: Preliminary results in patients with hip pain | |
| Florian Schmaranzer1,2, Eduardo Novais2, Young-Jo Kim2, Tobias Kober3,4,5, Bernd Jung1, Sarah Bixby6, and Onur Afacan6 | ||
1Department of Diagnostic, Interventional and Pediatric Radiology, University of Bern, Inselspital Bern, Bern, Switzerland, 2Department of Orthopaedic Surgery, Harvard Medical School, Boston Children`s Hospital, Boston, MA, United States, 3Advanced Clinical Imaging Technology, Siemens Healthcare, Lausanne, Switzerland, 4Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 5École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 6Department of Radiology, Harvard Medical School, Boston Children`s Hospital, Boston, MA, United States |
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Current standard techniques for T1 mapping of hip cartilage are affected by flip angle variations due to B1-field inhomogeneities at 3T. The aim was to prospectively compare a 3D MP2RAGE for T1 mapping of cartilage to a 2D-IR based reference standard in the patients with hip pain undergoing indirect MR arthrography. 3D MP2RAGE correlated well with the 2D-IR reference standard and showed a minor systematic bias. This supports the continued use of 3D MP2RAGE in patients undergoing joint preserving hip surgery with the goal to establish prognostic predictors to predict the success or failure of these interventions. |
| 2753 | Investigation into the effect of spin-lock frequency on the angular dependence of T1rho in in-vivo measurements of femoral knee cartilage at 3T | |
| Laurel Hales1 and Feliks Kogan2 | ||
1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States |
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Given the use of T1rho as a measure of cartilage health and an early indicator for osteoarthritis, it is important to understand the T1rho relaxation mechanism including its somewhat unexplained angular dependence. In the hope of finding a range of spin-lock frequencies (FSLs) with a decreased angular dependence, we generated T1rho maps of in-vivo femoral knee cartilage at various FSLs from 100Hz to 1kHz. We found a visible angular dependence in T1rho measurements for all FSLs including 1kHz. If there exists a range of FSL with little or no angular dependence it is higher than 1kHz. |
| 2754 | Cluster analysis of T2 changes is related to acute exercise in individuals with knee osteoarthritis | |
| Lauren Watkins1, Valentina Mazzoli2, Marianne Black3, Scott Uhlrich3, Brian Hargreaves1,2,4, Garry Gold2, and Feliks Kogan2 | ||
1Bioengineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States, 3Mechanical Engineering, Stanford University, Stanford, CA, United States, 4Electrical Engineering, Stanford University, Stanford, CA, United States |
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Degradation of articular cartilage related to osteoarthritis is associated with changes in cartilage T2 relaxation times that may not be uniform across the cartilage surface. Analysis of changes in T2 times longitudinally or in response to mechanical loading can assist in detection of regions of cartilage damage. Here we examine the ability of cluster analysis to reflect transient changes in cartilage T2 times in response to acute loading. Osteoarthritic subjects who performed a squat exercise had a greater percent of the cartilage area with negative changes in T2 times compared to healthy and osteoarthritic subjects who did not exercise. |
| 2755 | Bias and correction method of UTE trajectory errors in the depiction and relaxometry of deep articular cartilage | |
| Sophia Kronthaler1, Jürgen Rahmer2, Peter Börnert2, Alexandra S. Gersing1, Benedikt J. Schwaiger1, Roland Krug3, and Dimitrios C. Karampinos1 | ||
1Department of Diagnostic and Interventional Radiology, Technical University of Munich, School of Medicine, Munich, Germany, 2Philips Research Laboratory, Hamburg, Germany, 3Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States |
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Imaging of the morphological and biochemical composition of the deep articular cartilage has important implications in the assessment of osteoarthritis. The deep cartilage layer has intrinsically short T2* characteristics and ultra-short echo time (UTE) imaging techniques have been recently employed in the depiction of the deep cartilage layer morphology. UTE imaging is known to be affected by k-space trajectory errors. The purpose of the present work is to investigate the effect of trajectory errors in UTE imaging used for the depiction and relaxometry of deep articular knee cartilage. A GIRF-correction is applied to correct eddy-currents induced k-space trajectory errors. |
| 2756 | Feasibility of UTE T2* cartilage mapping in the sacroiliac joints | |
| Tony T Wong1, Patrick Quarterman1, Phuong Duong1, Diego Jaramillo1, Michael Liu1, and Sachin R Jambawalikar1 | ||
1Columbia University Medical Center, New York, NY, United States |
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Ultrashort echo time (UTE) T2* images of 20 sacroiliac joints were acquired in 10 asymptomatic volunteers. Each sacroiliac (SI) joint was segmented manually and divided into thirds (superior, middle, and inferior). Differences in mean UTE T2* values were assessed. Results demonstrated a mean UTE T2* value of 10.38 ± 0.62 ms in the SI joints. There was no statistical significance between right and left sides (p = 0.89), superior, middle, and inferior third regions (p = 0.86), or males and females (p = 0.47). Intra-observer variability with ICC ranged from 0.89-0.98. |
| 2757 | Analysis of T2 and T2* relaxation time reproducibility within hip joint cartilage | |
| Jessica Bugeja1,2, Ales Neubert1,2, Shekhar Chandra1, Jurgen Fripp2, Craig Engstrom1, and Stuart Crozier1 | ||
1University of Queensland, Brisbane, Australia, 2CSIRO, Brisbane, Australia |
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QMRI sequences including T2 and T2* mapping analyse biochemical changes of cartilage including the deterioration of the ECM and changes in water content for early diagnosis of hip OA prior to serious cartilage degradation. Longitudinal studies and clinical assessments with T2 and T2* mapping rely on a high reproducibility of the tissue relaxation times for accurate diagnosis. We present a statistical analysis of the reproducibility of T2 and T2* mapping of hip MR images. An automated cartilage segmentation method is used for the segmentation of FISP MR hip images and biochemical information is obtained from the T2 and T2* images. |
| 2758 | Evaluation of bone marrow proton density fat fraction in β-thalassaemia patients and healthy subjects using 1H-MR spectroscopy. | |
| Umi Nabilah Ismail1, Che Ahmad Azlan1, Shasha Khairullah2, Kuan Jin Lee3, Chai Hong Yeong4, Nur Farhayu Omar5, Mohammad Nazri M Shah1, Raja Rizal Azman Raja Aman1, Nicholas Jackson6, and Kwan Hoong Ng1 | ||
1Biomedical Imaging Department, University of Malaya, Kuala Lumpur, Malaysia, 2Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia, 3Singapore Bioimaging Consortium, A*STAR Research, Singapore, Singapore, 4School of Medicine, Faculty of Health and Medical Sciences, Taylor's University Lakeside Campus, Subang Jaya, Malaysia, 5Department of Imaging, Universiti Putra Malaysia, Serdang, Malaysia, 6Department of Pathology, University of Malaya, Kuala Lumpur, Malaysia |
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Fat in bone marrow is stated to be regulated by the body haematopoietic needs. We explored this by measuring bone marrow fat fraction(FF) of healthy subjects and β-thalassaemia patients who required treatment to suppress their body haematopoietic needs. The results obtained from 1H-MR Spectroscopy suggested that information about marrow adipocytes may be useful in evaluating patients' treatment response. |
| 2759 | Variable flip angle T1 Relaxometry of cortical bone free water; correlation with the mechanical compression test | |
| Mahsa Talebi1,2, Shahrokh Abbasi-Rad3, Malakeh Malekzadeh1,4, Mohamad Shahgholi5, Kimia Foudeh5, and Hamidreza Saligheh Rad1,2 | ||
1Quantitative MR Imaging and Spectroscopy Group, Research Center for Cellular and Molecular Imaging, Tehran University of Medical Sciences, Tehran, Iran, Tehran, Iran (Islamic Republic of), 2Medical Physics and Biomedical Engineering Department, Tehran University of Medical Sciences, Tehran, Iran, Tehran, Iran (Islamic Republic of), 3Quantitative MR Imaging and Spectroscopy Group, Research Center for Cellular and Molecular Imaging, Tehran University of Medical Sciences, Tehran, Iran, Brisbane, Australia, 43Medical Physics Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran, Tehran, Iran (Islamic Republic of), 5Department of Mechanical Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran, Najaf Abad, Iran (Islamic Republic of) |
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Cortical bone porosity contributes to bone quality but is under the limit of the current clinical imaging modalities’ resolution. T1 value of water molecules residing in cortical bone pores is linked with their mobility. Since the changes in surface-to-volume ratio of the pores affect cortical bone mechanical properties, we assumed that free water T1 (T1,free) would model the mechanical properties of cortical bone. Variable flip angle, variable TR, and inversion recovery methods were used to quantify T1,free and their correlation with bone toughness was assessed. The results showed VFA T1,free could predict the cortical bone toughness (r = -0.63, p<0.01). |
| 2760 | Detection of femoral head ischemia using DCE-MRI in Children with Slipped Capital Femoral Epiphysis (SCFE) | |
| Kojiro Ono1,2, Yasuhiro Oikawa3, Shinya Obara1, and Hideaki Haneishi2 | ||
1Radiology, Chiba Children's Hospital, Chiba, Japan, 2Center for Frontier Medical Engineering, Chiba University, Chiba, Japan, 3Orthopedics, Chiba Children's Hospital, Chiba, Japan |
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In this study, we reveal a scheme to evaluate the femoral head ischemia using optimized DCE-MRI for preoperative diagnosis in children with unstable SCFE. The consistency of the evaluation of DCE-MRI is verified through compare the cases which were classified as ischemia or normal after surgery. As a result, optimized DCE-MRI is a useful tool to detected femoral head ischemia in children with unstable SCFE, which allows doctors to plan a treatment strategy ahead of time. PEI and MTE using DCE-MRI contribute to an objective evaluation of the perfusion status.
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| 2761 | Vertebral Marrow Microenvironment Indexes in Middle-aged and Elderly People with Varying Bone Mineral Density: Functional MRI Evaluation | |
| Jingqi Zhu1, Xueli Zhang1, Yun Tu1, Rui Tang1, Rui Ji1, Jilei Zhang2, Ting Hua1, and Guangyu Tang*1 | ||
1Department of Radiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China, 2Clinical Science, Philips Healthcare, Shanghai, China |
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Our study found that the differences of the parameters of mDIXON-Quant and IVIM-DWI [T2*, fat fraction (FF) and f values] among three groups with varying bone mineral density (normal, osteopenic and osteoporotic) were statistically significant. The correlations of the T2* and FF values with T-score were negative and the correlations of the D* and f values with T-score were positive. Our study implies that mDIXON-Quant and IVIM-DWI techniques were helpful to reflect the changes of vertebral marrow microenvironment of osteoporosis, which may provide valuable information for the assessment of the bone quality. |
| 2762 | Angular dependence of UTE signal of mouse femur– a pilot study of assessing structure of collagen matrix using MRI | |
| Minghui Tang1, Ken Masuyama2, Takayoshi Nakano3, and Toru Yamamoto1 | ||
1Hokkaido University, Sapporo, Japan, 2Teine Keijinkai Hospital, Sapporo, Japan, 3Osaka University, Osaka, Japan |
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Collagen fibers in the healty cortical bone tends to align to the bone axis, and the degree of this orientation is one of dominant factors to determine bone strength. Because microscopic R2* around a collagen fiber is anisotropic, we investigated how the UTE signal from mice femurs (normal and osteopetrotic) varies by changing the angle between the bone axis and B0 for future MRI evaluation of bone strength. The angular dependence of UTE signal of a knockout osteopetrotic mouse decreased 1/5 of a normal mouse. This decrease reflects deterioration of collagen fiber orientation that is a pathological evidence of osteopetrosis. |
| 2763 | Gender-related variation of IVIM diffusion weighted imaging observed in lumbar vertebral bone marrow: a healthy volunteer study | |
| Fan Qing1, Ren Huipeng1, Wang Xiaohu1, Shen Tianbo1, Wei Xiaocheng2, and Ren Zhuanqin1 | ||
1Baoji Central Hospital, Shaanxi Province, Baoji, China, 2GE Healthcare, MR Research China, Beijing, China |
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Despite the fact that diffusion MRI is well established in bone marrow as a valuable imaging modality, only a limited number of studies have investigated the intravoxel incoherent motion (IVIM) approach. In this study, bi-exponential IVIM was used to measure diffusion and perfusion fraction in lumbar vertebral bone marrow in 99 healthy subjects. The results demonstrated a gender-related variation in D and f while D* was an independent factor. Our findings may help to better understand the variation of water diffusion and perfusion imaging in lumbar vertebral bone marrow in-vivo with healthy and pathological condition. |
| 2764 | Application of Multi-echo Dixon Technique and IVIM-DWI in Patients with Primary Osteoporosis : A Preliminary Study with 3.0 T MRI | |
| Fan Qiuju1, Tan Hui1, Yang Zhen1, Yu Nan1, Yu Yong1, Wang Shaoyu2, Xue Yu3, and Li Yue3 | ||
1Affiliated Hospital of Shaanxi University of Chinese Medicine, Shaanxi, China, 2MR senior scientific marketing specialist, Shaanxi, China, 3Shaanxi University of Chinese Medicine, Shaanxi, China |
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This study aimed to investigate the role of multi-echo Dixon technique and IVIM-DWI in assessing vertebral marrow changes among subjects with osteoporosis, osteopenia and normals. The multi-echo Dixon technique and IVIM-DWI were used to evaluate 26 healthy volunteers, 26 osteopenia patients and 24 osteoporosis patients. The FF, D and D* among osteoporosis, osteopenia and normals were significantly different.Furthermore, we found that there was a statistically significant positive correlation between D value and T-score,while the D* value and FF were negatively correlated to the T-score. |
| 2765 | The potential clinical value of a quantitative Dixon sequence in predicting bone marrow fat on the lumbar spine | |
| Ying Li1, Cuiping Ren1, Jingliang Cheng1, Jinxia Zhu2, and Stephan Kannengiesser3 | ||
1MRI, The first affiliated hospital of Zhengzhou university, Zhengzhou, China, 2MR Collaboration, Siemens Healthcare Ltd., Beijing, China, 3Siemens Healthcare GmbH, Erlangen, Germany |
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Osteoporosis is a systemic disease characterized by low bone mass with increased fracture risk. This work investigated and evaluated the role of the quantitative Dixon sequence in predicting the bone marrow fat on the lumbar spine, which might provide quantitative imaging parameters for accurately predicting fracture risk in patients with osteoporosis. |
| 2766 | The feasibility study of 3D adiabatic inversion recovery prepared ultrashort TE Cones sequence in the evaluation of osteoporosis | |
| Jin Liu1, Yajun Ma2, Xiaojun Chen1, Jianwei Liao1, Wei Li1, Yinghua Zhao3, Yijie Fang1, Long Qian4, Jiang Du2, and Shaolin Li1 | ||
1Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Guangdong, China, 2University of California, San Diego, California, San Diego, CA, United States, 3The Tird Affiliated Hospital of Southern Medical University, Guangdong, China, 4MR Research, GE Healthcare, Beijing, China |
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The current study aims to assess the feasibility of proton density (PD) in the lumbar using 3D adiabatic inversion recovery prepared ultrashort TE cones (3D IR‐UTE‐Cones) sequence. In addition, the latent associations between the PD and BMD, age, gender, the oswestry disability index (ODI) were evaluated, respectively. It was concluded that proton density of trabecular bone can be applied in lumbar. Moreover, the proton density of lumbar were observed to correlate with BMD, age and ODI, which need further study to clarify this topic. |
| 2767 | Simultaneous imaging of trabecular and cortical bone by analyzing the multi-echo signal decay at UTEs and conventional TEs | |
| Sophia Kronthaler1, Christof Böhm1, Dominik Weidlich1, Maximilian N. Diefenbach1,2, and Dimitrios C. Karampinos1 | ||
1Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany, 2Division of Infectious Diseases and Tropical Medicine, Munich, Germany |
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Osteoporosis is characterized by a loss in bone mass and structural decrease of bone tissue which is leading to morbidity and an increased fracture risk. Fractures occur predominantly in areas with trabecular bone and the assessment of the bone volume and microstructural changes in the trabecular bone are therefore highly relevant in fracture prediction. The present study characterizes the decay of trabecularized bone marrow signal in multi-echo imaging sampling both UTEs and conventional TEs. A novel methodology is proposed for simultaneous cortical and trabecular bone imaging in the presence of bone marrow. |
| 2768 | FRACTURE: FFE Resembling A CT Using Restricted Echo-spacing: A Novel MRI Technique for Bone Evaluation | |
| Brian Johnson1, Ivan E. Dimitrov1, Sandeep Ganji1, and Molly Dempsey 2 | ||
1Philips Healthcare, Gainesville, FL, United States, 2Texas Scottish Rite Hospital for Children, Dallas, TX, United States |
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Computed tomography (CT) is the current modality of choice for imaging bone yet it suffers from poor soft tissue contrast and utilizes ionizing radiation. Unlike CT, MRI provides excellent soft-tissue contrast, but is limited in its ability to image bone. Here, we describe FRACTURE (FFE Resembling A CT Using Restricted Echo-spacing), a novel 3D gradient-echo approach that offers MRI-based bone contrast to yield clinically relevant information for patient management. |
| 2769 | 3T CSE-MRI of multiple adipose tissue in osteoporosis patient with varying fracture risk | |
| Dimitri Martel1, Stephen Honig2, and Gregory Chang1 | ||
1Radiology, NYU Langone Health, New York, NY, United States, 2Osteoporosis Center, NYU Langone Health, New York, NY, United States |
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Osteoporosis (OP) is a disease of weak bone associated with an increased fracture risk. Recent studies using Chemical Shift Encoded MRI has been previously used to show differences in term of fat amount related to osteoporosis condition in spine and femur. The aim of our study is to use CSE-MRI in muscle, bone marrow and subcutaneous fat of the pelvic region in osteoporosis patient with varying degree of fracture risk. |
| 2770 | Simultaneous evaluation of bone and cartilage status in asymptomatic FAI subjects and healthy controls using PET-MRI | |
| Gerd Melkus1,2, Kawan Rakhra1,2, Reggie Taylor3, Katie Dinelle3, Stephen Dinning4,5, and Paul Beaulé5,6 | ||
1Medical Imaging, The Ottawa Hospital, Ottawa, ON, Canada, 2Radiology, University of Ottawa, Ottawa, ON, Canada, 3Brain Imaging Centre, The Royal Hospital, Ottawa, ON, Canada, 4Nuclear Medicine, The Ottawa Hospital, Ottawa, ON, Canada, 5Medicine, University of Ottawa, Ottawa, ON, Canada, 6Orthopaedic Surgery, The Ottawa Hospital, Ottawa, ON, Canada |
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In this study subjects with asymptomatic FAI and healthy controls underwent PET-MRI to investigate hip bone activity (by [18F]-Sodium Fluoride (NaF) PET) and hip cartilage proteoglycan content (by MRI T1ρ mapping). The FAI subjects showed an increased [18F]-NaF uptake in the femoral head neck junction and in lateral area of the acetabulum, indicating increased bone remodelling. Hip cartilage T1ρ values were significantly higher in the anterior-lateral region for the FAI group, revealing a loss of proteoglycan with a possible connection to an early osteoarthritis stage. PET-MRI has potential to be a useful non-invasive tool to research FAI in vivo. |
| 2771 | Idiopathic osteonecrosis of the scaphoid (Preiser’s disease): Viability patterns in contrast-enhanced MRI | |
| Jan-Peter Grunz1,2, Carsten Herbert Gietzen1,2, Andreas Steven Kunz1, Thorsten Alexander Bley1, and Rainer Schmitt1,2 | ||
1Institute of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany, 2Department of Diagnostic and Interventional Radiology, Rhön-Klinikum Campus Bad Neustadt, Bad Neustadt a. d. Saale, Germany |
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With the ability to non-invasively display different viability patterns in the scaphoid bone, contrast-enhanced MRI is a powerful tool for detection and staging of Preiser’s disease. To our best knowledge, this study includes the largest patient sample undergoing MRI for idiopathic osteonecrosis of the scaphoid to date, thus expanding the knowledge on this rare disease entity. Our results suggest that the size of scaphoid necrosis is considerably overestimated in unenhanced MRI because necrotic bone cannot be reliably differentiated from vascularized repair tissue. Influencing decision on therapy, the extent of osteonecrosis should consequently not be assessed without administration of contrast agent. |
| 2772 | MRI assessment of bone microarchitecture in Human Bone samples: The issue of air bubbles artefacts | |
| Enrico Soldati1, Martine Pithioux2, David Bendahan3, and Jerome Vicente1 | ||
1IUSTI, AixMarseille, Marseille, France, 2ISM, AixMarseille, Marseille, France, 3CRMBM, AixMarseille, Marseille, France |
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With the aim of assessing bone microarchitecture, several studies have intended to use MRI but the issue of air bubbles artefacts has been very scarcely reported. In the present study, we assessed air bubbles-related artefacts in MR images of human bone samples and intended to design a protocol to eliminate them. The method was validated using TSE MRI at 3T and high-resolution X-ray micro tomography. Morphological parameters computed from MRI recorded with and without the air bubbles artefacts were compared to those obtained from X-ray micro tomography. |
| 2773 | The Vertebral Marrow Microstructure in Healthy Young Adults with Intravoxel Incoherent Motion Diffusion-weighted MRI | |
| Jinliang Niu1, Kaiyu Wang2, Wenqi Wu1, Tong Gong3, Jianting Li4, and Rong Zheng4 | ||
1Shanxi Medical University Second Affiliated Hospital, Taiyuan, China, 2GE Healthcare, MR Research China, Beijing, Beijing, China, 3Sichuan Provincial People's Hospital, Chengdu, China, 4Shanxi Medical University, Taiyuan, China |
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Intravoxel incoherent motion diffusion-weighted MRI (IVIM) plays an important role in detecting and monitoring microstructure. It offers diffusion and perfusion information at the same time without contrast agents. In this work, we demonstrated IVIM parameters can discriminate the microstructure of marrow in younger women from men compared with the apparent diffusion coefficient (ADC) values. It may provide noninvasive methods for evaluating cellularity, vascular volume and blood velocity of bone marrow. |
| 2774 | Predicting cortical bone microstructural properties by water proton density obtained from ultrashort echo time (UTE) MRI | |
| Saeed Jerban1, Yajun Ma1, Hyungseok Jang1, behnam namiranian1, Nicole Le2, Hoda Shirazian1, Mark Murphy3, Jiang Du1, and Eric Y Chang2 | ||
1Radiology, University of California, San Diego, San Diego, CA, United States, 2Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States, 3Orthopaedic Service, VA San Diego Healthcare System, San Diego, CA, United States |
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Cortical bone porous microstructure can be potentially predicted by the total water density in bone. Comparing bone signal from a relatively fast ultrashort echo time MRI (UTE-MRI) scan against the signal of a known external reference (rubber eraser) enabled us to measure total water proton density (TWPD) in 135 cortical bone specimens from 37 donors. We observed significant correlations between bone TWPD and micro computed tomography (μCT) measures (porosity, pore size, and bone mineral density, (BMD)). This relatively fast MRI technique may aid diagnosing and monitoring bone diseases. |
| 2775 | Quantitative Magnetization Transfer Imaging of the Lumbar in Primary Osteoporosis at 3T MRI: a Feasibility Study | |
| Fan Qiuju1, Tan Hui1, Yang Zhen1, Yu Nan1, Yu Yong1, Wang Shaoyu2, Xue Yu3, and Li Yue3 | ||
1Affiliated Hospital of Shaanxi University of Chinese Medicine, Shaanxi, China, 2MR senior scientific marketing specialist, Shaanxi, China, 3Shaanxi University of Chinese Medicine, Shaanxi, China |
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This study aimed to assess the association between the magnetization transfer ratio (MTR) value and bone mineral density (BMD) in lumbar vertebral among normal, osteopenia and osteoporosis. The MT technique was used to evaluate 26 healthy volunteers, 26 osteopenia patients and 24 osteoporosis patients. The MTR in the osteoporotic, osteopenic, and normal BMD groups were statistically significant differences. Therefore, MT technique provide quantitative information about the contribution of macromolecules., which can be used as a non-invasive quantitative monitoring MRI tool for osteoporosis progression. |
| 2776 | Quantitative MRI Study of Diabetic Bone Marrow Microvascular Disease | |
| Pianpian Chen1, Weiyin Vivian Liu2, and Yunfei Zha3 | ||
1Hospital of Stomatology Wuhan University, Wuhan, China, 2MR Research, GE Healthcare, Beijing, China, 3Renmin Hospital of Wuhan University, Wuhan, China |
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We quantitatively evaluate the microvascular permeability of lumbar marrow changes in alloxan-induced diabetic rabbits using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) . And to investigate whether texture analysis based on permeability parameter Ktrans map of DCE-MRI can be used to assess the fine alterations of lumbar marrow structures in early-stage diabetic rabbits. Our results confirm that texture analysis parameters based on DCE-MRI quantitative parameter Ktrans map are feasible to identify the early-stage fine changes of lumbar marrow structure in diabetic rabbits. |
| 2777 | Correlation study of rabbit knee joint contour using high-resolution CT and MRI. | |
| Yang Xia1, Farid Badar1, and Sarah Salem1 | ||
1Physics, Oakland University, Rochester, MI, United States |
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Correlated application of high-resolution MRI T2 of intact rabbit knee joints with the aid of bone density properties measured by isotropic high-resolution µCT. The combined multi-model study will aid in the understanding of the relationship between underlying bone-density changes and osteoarthritic cartilage in joint degeneration. |
| 2778 | MRI models of the Age-Related Bone Loss: Insights from Multi-modal Imaging Study | |
| Malakeh Malekzadeh1, Shahrokh Abbasi-Rad 2, Mohammad Bagher Shiran1, Mojgan Asadi3, Mehdi Shamsi4, Navid Tofighi Rad4, and Hamidreza Saligheh Rad5 | ||
1Iran University of Medical Science, Tehran, Iran (Islamic Republic of), 2Quantitative Medical Imaging Systems Group, Tehran, Iran (Islamic Republic of), 3Tehran University of Medical Science, Tehran, Iran (Islamic Republic of), 4Laleh Hospital, Tehran, Iran (Islamic Republic of), 5Tehran University of medical science, Tehran, Iran (Islamic Republic of) |
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This study deals with assessing the ability of current clinical measures of bone to model the systematic age-related alteration of bone during aging and where does MRI stand as a new modality. Fifty Healthy volunteers with an average age of 44.53 ±7.95 were enrolled based on oral interviews and blood tests. Quantitative measurements were performed by various modalities for lumbar spine, forearm (DXA), Calcaneus (QUS), and Tiba (QCT and MRI). Pearson correlation coefficients was calculated between the bone parameters and age. The highest correlation coefficient between bone parameters and age was related to T1 (r = 0.766, p <0.01). |
| 2779 | Zero Echo Time Imaging of the knee | |
| Saya Horiuchi1, Taiki Nozaki1, Shigekazu Funada1, Atsushi Nozaki2, Hiroyuki Kabasawa2, Yasuyuki Kurihara1, and Nobuto Kitamura3 | ||
1Radiology Department, St. Luke's International Hospital, Tokyo, Japan, 2GE Healthcare, Japan, Tokyo, Japan, 3Orthopedic Department, St. Luke's International Hospital, Tokyo, Japan |
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Zero Echo Time (ZTE) MR imaging provides “CT-like” contrast for cortical bone of the knee. We compared sagittal images of CT and ZTE of 15 patients, and demonstrated inter-modality agreement between morphology of the cortical bone of the tibia from CT and ZTE images. Metallic screws were blurred on ZTE in patients who underwent Anterior cruciate ligament (ACL) reconstruction. ZTE may be used clinically instead of CT in some cases who can undergo ACL reconstruction. |
| 2780 | 3T MRI Textural Analysis of the Proximal Femur in Subjects with Compared to Those without Prior Fragility Fractures | |
| Anmol Monga1, Dimitri Martel1, Stephen Honig2, and Gregory Chang1 | ||
1Radiology, NYU Langone Health, New York, NY, United States, 2Osteoporosis Center, NYU Langone Health, New York, NY, United States |
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In recent years, there is greater emphasis on detecting microstructural information in bones that may lead to improved diagnosis of osteoporosis in patients. Radiomics provides a tool to quantify the textural information of medical images and may serve as a marker of bone microstructure. We aim to analyze if the distribution of the textural features computed in the proximal femur is significantly in subjects with previous fragility fractures compared to those without fracture. |
| 2781 | Evaluation of Gadolinium Deposition in Cortical Bone Using 3D-UTE-QSM in vitro: Preliminary Study | |
| Xiaodong Zhang1,2, Hyungseok Jang2, Yanjun Chen1,2, Zhenyu Cai2, Ya-Jun Ma2, Wei Zhao2, Yanqiu Feng3, and Jiang Du2 | ||
1Department of Radiology, Third Affiliated Hospital of Southern Medical University, Guangzhou, China, 2Department of Radiology,University of California San Diego, San Diego, CA, United States, 3School of Biomedical Engineering, Southern Medical University, Guangzhou, China |
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After injection of gadolinium-based contrast agents (GBCAs) for enhanced magnetic resonance imaging (MRI), levels of gadolinium (Gd) in the brain are much lower than that measured in bone. The 3D ultrashort echo time Cones Quantitative susceptibility mapping (3D UTE-Cones-QSM) technique has been used to assess calcium in cortical bone. In this study, we investigated the feasibility of evaluating gadolinium deposition in cortical bone in vitro using 3D UTE-Cones-QSM on a 3T clinical scanner. Higher QSM values were observed with higher Gd concentrations, indicating that 3D UTE-Cones-QSM could be a new, non-invasive technique for evaluation of Gd deposition in bone. |
| 2782 | Bone Imaging in Musculoskeletal Trauma with Zero Echo-Time MRI | |
| Ryan E Breighner1, Matthew F Koff1, and Hollis G Potter1 | ||
1Radiology and Imaging, Hospital for Special Surgery, New York, NY, United States |
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Zero Echo Time (ZTE) MRI yields positive contrast for bone visualization using MRI. The present study highlights cases in which ZTE provides additional diagnostic information in the context of orthopedic trauma. The presented cases are ones in which MRI was deemed necessary for the evaluation of ligament, tendon, or nerve integrity and ZTE was added to aid in the assessment of fractures. In conjunction with our prior work, this study demonstrates that ZTE MRI provides additional diagnostic information in musculoskeletal MRI, specifically in the context of joint trauma. |
| 2783 | Do We Need CT for Producing a Fully-Automatic 3D Scapular Model? MRI meets Deep Learning for Scapular Bone Extraction | |
| Francesco Caliva1, Victoria Wong1, Roland Krug1, Drew Lansdown1, and Valentina Pedoia1 | ||
1University of California, San Francisco, San Francisco, CA, United States |
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We present a fully-automatic, 2D deep learning based strategy for extracting scapular shape from a high-resolution MRI scan and we quantify network’s segmentation uncertainty. Our method has the potential to greatly improve the diagnostic process for patients with shoulder instability, rotator cuff tears, and osteoarthritis by decreasing the need for multiple imaging scans and ionizing radiation while still providing clinically-useful information to clinicians. |
| 2784 | Comparative analysis of the diagnostic values of T2 mapping and DWI for sacroiliitis in ankylosing spondylitis | |
| Dongdong Wang1, Huijia Yin1, Wenling Liu1, Zhong Li1, Wenguang Dou1, Dongming Han1, and Kaiyu Wang2 | ||
1The First Affiliated Hospital of Xinxiang Medical University, Weihui, China, 2GE Healthcare, MR Research China, Weihui, China |
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In this study, we compared and analyzed the active, inactive, and healthy control groups using T2 mapping and assessed the activity of AS using the changes in T2 values. The purposes of this study are to use T2 mapping to assess AS activity, to compare the quantitative assessment values of T2 mapping and DWI for subchondral bone marrow edema of the sacroiliac joint, and to provide potential imaging technical support for the clinical diagnosis of AS and efficacy evaluations of AS treatments. |
| 2785 | Assessment of Ankylosing Spondylitis Activity with Intravoxel Incoherent Motion Diffusion Weighted and Dynamic Contrast-Enhanced MR Imaging | |
| Mengyue Wang1, Wentao Wang2, Lei Xu1, Liang Qi1, and Yuefen Zou1 | ||
1Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China |
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Effective diagnosis of ankylosing spondylitis (AS) activity plays an important role for clinical treatment and prognosis. In our study, we used intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) to differentiate the active and chronic stage of AS. As a result, we found that Dslow, Ktrans and Ve had a high diagnostic sensitivity and specificity. |
| 2786 | Quantification of joint capsule laxity of the tibiotalar and subtalar joints in ballet dancers at 3T MRI | |
| Toshimi Tando1, Saya Horiuchi1, Hon J. Yu1, Alex Luk1, Jeffrey A. Russell2, Kelli Sharp3, and Hiroshi Yoshioka1 | ||
1Department of Radiological Sciences, University of California, Irvine, Orange, CA, United States, 2Science and Health in Artistic Performance, Ohio University, Athens, OH, United States, 3Department of Dance, The Claire Trevor School of the Arts, University of California, Irvine, Irvine, CA, United States |
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Joint capsule laxity/thickening is one of predisposing factors of posterior ankle impingement syndrome. The purpose of this study is to quantitatively evaluate size of the tibiotalar and subtalar joint recesses in MR images in ballet dancers, compared to non-dancers. The results showed that posterior subtalar joint recess volume, distal tibiofibular joint area, medial posterior tibiotalar recess area, and medial posterior capsule distance were larger in female dancers than female non-dancers. These findings indicate that joint capsule laxity can be measured quantitatively and used for quantitative evaluation of posterior ankle impingement. |
| 2787 | Advanced Knee Imaging Study in NCAA Division 1 Basketball Update: Study Design and Considerations for Multi-Site Longitudinal Study | |
| Katherine A Young1, Elka Rubin1, Feliks Kogan1, Marianne S Black1, Madeleine Gao2, John M Sabol3, Marc Safran4, Matthew F Koff5, Hollis Potter5, Sharmila Majumdar6, and Garry Gold7 | ||
1Radiology, Stanford University, Stanford, CA, United States, 2Radiology, Hospital for Special Surgery, New York City, NY, United States, 3GE Healthcare, Waukesha, WI, United States, 4Stanford University, Redwood City, CA, United States, 5Hospital for Special Surgery, NYC, NY, United States, 6University of California San Francisco, San Francisco, CA, United States, 7Stanford University, Stanford, CA, United States |
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Knee injuries are especially common in jumping athletes, and, in particular, elite basketball players. We present an update two years into a multi-site study analyzing the results of a common phantom in assessing biases across and within MRI scanners, as well as to characterize the effectiveness of recruitment, assessment, and study design strategies. It was shown that more timepoints of quantitative values potentially corrects for quantitative biases longitudinally within one scanner. As attrition rates are high for athletes in general, consistent and effective methods of recruitment, early identification of key athletes, and standardized methods of assessment are all necessary. |
| 2788 | Value of fractional anisotropy and apparent diffusion coefficient of diffusion tensor imaging in diagnosing early carpal tunnel syndrome | |
| Tsutomu Inaoka1, Ryosuke Sakai1, Hisanori Tomobe1, Masahiro Sogawa1, Akinori Yamamoto1, Takamitsu Uchi1, Sayuri Kato1, Rumiko Ishikawa1, Tomoya Nakatsuka1, Noriko Kitamura1, Shusuke Kasuya1, and Hitoshi Terada1 | ||
1Radiology, Toho University Sakura Medical Center, Sakura, Japan |
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There are decreased FA and increased ADC significantly with age in healthy subjects. There are significant differences in FA and ADC between early-stage CTS subjects and age-matched healthy subjects. 0.56 was found to be cutoff value for FA with 89% sensitivity and 88% accuracy and 0.75x10-3mm2/s was found to be cutoff value for ADC with 79% sensitivity and 78% accuracy. Although FA and ADC well correlate with clinical examinations and NCS results, the value of FA is much stronger than that of ADC for diagnosing CTS earlier. DTI can be used for the early diagnosis of CTS. |
| 2789 | The Feasibility of the Simultaneous Multi-slice BLADE Technique in Shoulder Imaging | |
| Yincong Dou1, Jing An2, Kun Zhou2, Xianchang Zhang3, Fengshan Yan1, Shewei Dou1, and Meiyun Wang1 | ||
1Department of Radiology, Henan Provincial People’s Hospital, Zhengzhou, China, 2Siemens Shenzhen Magnetic Resonance Ltd.,, Shenzhen, China, 3MR Collaboration, Siemens Healthcare Ltd.,, Shenzhen, China |
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The purpose of this study was to evaluate the use of Simultaneous Multi-slice BLADE technique for artifact reduction and overall image quality improvement of the shoulder. All the patients underwent the conventional TSE and SMS BLADE sequences. The images were graded by two radiologists for image artifacts, overall image quality, and delineation of anatomic structure. The results showed that the new technique can significantly reduce artifacts, shorten scanning time, improve overall image quality, display more detailed anatomical structures and provide better clinical diagnostic images than conventional shoulder joint sequence. |
| 2790 | Evaluating the preoperative diagnose of lumbosacral radiculopathy using diffusion tensor imaging and tractography | |
| Zhao Feng1, Shi Yin1, Dou Weiqiang2, Shi Haibin1, and Ren Yongxin1 | ||
1The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2GE Healthcare, MR Research, Beijing, P.R. China, Beijing, China |
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The aim of this study is mainly to explore the pre-diagnosis value of DTI technology applied to lumbosacral radiculopathy (LSR). By measuring 80 patients with unilateral disc related lumbosacral nerve root compression, we found that DTI technology combined with tractography not only could identify the type of disc herniation, assess the degree of nerve root damage, but also confirm the responsible nerve root. Therefore, we can demonstrate that DTI combined with tractography can improve the diagnosis rate of LSR and reduce iatrogenic injury. |
| 2791 | Quantitative evaluation of pubic symphysis in late pregnancy using T2* mapping | |
| Tao Gong1, Jinxia Zhu2, and Guangbin Wang1 | ||
1Shandong Medical Imaging Research Institute, Jinan, China, 2Siemens Healthcare, MR Collaborations NE Asia, Beijing, China |
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Degenerative joint disease of pubic symphysis is the primary cause of groin pain during late pregnancy. T2* mapping is a reliable tool in articular cartilage imaging, has been widely used to evaluate the degeneration of knee joint and intervertebral discs, while no studies was found in the pubic symphysis during pregnancy. Our results indicated the T2* values of cartilage between pubic bones increased significantly during late pregnancy, which were mainly driven by the posterior sub-region of cartilage. This study suggests that T2* mapping is a sensitive quantitative method capable of detecting cartilage changes of pubic symphysis during pregnancy. |
| 2792 | Diagnostic value of MAVRIC-SL sequence in patients with suspected infection after orthopedic metal implantation | |
| Jingyi Zhu1, Lizhi Xie2, and Songbai Li1 | ||
1the Department of Radiology, First Affiliated Hospital of China Medical University, Shenyang,Liaoning, China, 2GE Healthcare, MR Research, Beijing, China |
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Multiacquisition with variable resonance image combination (MAVRIC-SL) sequence is a novel metal artifact reduction technique that can effectively reduce metal artifacts in patients who undergo joint replacement or fracture internal fixation. The purpose of this study was to investigate the diagnostic advantages of the MAVRIC-SL sequence MAVRIC-SL compared with conventional FSE sequence for patients with orthopedic metal implants who are suspected of having the infection. |
| 2793 | Brachial plexus imaging using DANTE-SPACE: comparison with conventional T2-SPACE at 3T | |
| Xiangchuang Kong1, Jie Meng1, Xiaoyong Zhang2, Huiting Zhang3, Xiaoming Liu1, and Dingxi Liu1 | ||
1radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2MR Collaborations, Siemens Healthcare, Shenzhen, China, Shenzhen, China, 3MR Scientific Marketing, Siemens Healthcare, Wuhan, China |
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Three-dimensional high-resolution visualization of brachial plexus using T2-weighted SPACE (T2-SPACE) sequence has very high clinical value for the evaluation of brachial plexopathy. However, conventional T2-SPACE is limited by the lack of relative contrast between nerves and their surrounding tissues. In contrast to T2-SPACE, DANTE-SPACE has been proposed with superior blood flow suppression and might be a potential alternative to address its shortcoming. The objective of this study was to evaluate the T2-weighted DANTE-SPACE for its capability to diagnose brachial plexus due to its superior blood flow suppression. |
| 2794 | Quantitative evaluation of compressed nerve roots treated by PETD in lumbosacral radiculopathy using diffusion tensor imaging | |
| Shi Yin1, Dou Weiqiang2, Shi Haibin1, and Ren Yongxin1 | ||
1The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2GE Healthcare, MR Research, Beijing, P.R. China, Beijing, China |
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In this study, we aim to investigate if diffusion tensor imaging can clinically evaluate lumbosacral radiculopathy before and after percutaneous transforaminal endoscopic discectomy. By measuring 66 patients pre- and post-operatively, we found the FA values at the proximal sub-regions (subarticular zone) are more effective and had a significant correlation with clinical symptoms. Besides, both located in the proximal sub-regions, the abnormal parts of DTT visualized nerves coincided with the changes of the FA values in compressed nerves before and after surgery. Therefore, in lumbosacral radiculopathy, DTI is a potential tool for clinical evaluation before and after PETD surgery. |
| 2795 | Multi-parametric MRI in the evaluation of lumbar intervertebral disc and cartilage endplate degeneration at clinical 3 T | |
| Qianqian Hu1, Weiqiang Dou2, Yong Shen3, Yuan Yin1, Qingqing Zhou1, Yusheng Yu1, and Hong Zhang1 | ||
1The affiliated Jiangning hospital of Nanjing medical university, Nanjing, China, 2GE Healthcare, MR Research China, Beijing, China, 3GE Healthcare, MR Research China, Nanjing, China |
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multi-parametric MRI was applied to qualitatively and quantitatively investigate the degenerations of lumbar intervertebral disc and cartilage endplate. After measuring twenty-nine patients with low back pain, we found that, for intervertebral discs, its relaxation properties of T2 and T1rho, the image SNR as well as the fat fraction revealed strong correlations with its degeneration degrees. Moreover, zero echo time (ZTE) imaging also showed promise in the visualization of cartilage endplate. Therefore, multi-parametric MRI can be considered an effective tool in the evaluation of spinal degeneration, especially at the early stage. |
| 2796 | Evaluation of the 3D VISTA sequence with compressed sensing acceleration for imaging of the ankle: a Preliminary study | |
| Liu Xiaoming1, Dai Meng1, Liu Xi1, Kong Xiangchuang1, and Wang Jiazheng2 | ||
1Departments of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2Philips Healthcare, Beijing, China |
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The three-dimensional (3D) high resolution volume isotropic FSE sequence of ankle magnetic resonance imaging has the capabilities of acquiring thin-sliced sections and performing MPR, at the cost of long scan time. Several recent studies showed that the compressed sensing(CS) helps to reduce scan time, which is especially beneficial in 3D imaging. The aim of this study was to investigate the feasibility of 3D VISTA imaging with CS in ankle joint imaging, in comparison to 3D-VISTA with parallel imaging (PI ). The results showed that the acquisition time of 3D-VISTA MRI was reduced with CS while the image quality was retained. |
| 2797 | Clinical feasibility of mobile medical screening for wrist injuries in tennis players using a small car-mounted MRI | |
| Tomoki Miyasaka1, Michiru Kajiwara1, Akito Kawasaki2, Yoshikazu Okamoto3, and Yasuhiko Terada1 | ||
1Institute of Applied Physics, University of Tsukuba, Tsukuba, Japan, 2Graduate School of Human Sciences, University of Tsukuba, Tsukuba, Japan, 3Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan |
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We have developed a portable MRI that can provide opportunities for mobile operation in many environments including screening and primary care suites. Here we showed clinical feasibility of mobile medical screening using the portable MRI. We transported the scanner to a tennis club and imaged the wrists of 21 junior tennis players. The image quality was high enough to detect the TFCC injuries in most cases. Our results indicate that the portable system could be applicable for mass screening and early diagnosis of wrist injuries. |
| 2798 | AcidoCEST-UTE MRI is a Reproducible Method to Measure Cartilage and Meniscus pH | |
| Rachel A High1,2, Yang Ji1, Ya-Jun Ma1, Qingbo Tang2, Mark E Murphy3, Jiang Du1, and Eric Y Chang1,2 | ||
1Radiology, University of California San Diego, San Diego, CA, United States, 2Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States, 3Orthopedic Surgery Service, VA San Diego Healthcare System, San Diego, CA, United States |
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The acidification of musculoskeletal tissues is being investigated as a way to localize pain in osteoarthritis. AcidoCEST-UTE MRI can measure pH in tissues such as cartilage and meniscus, though in vivo validation is difficult. Thus, it is imperative that the acidoCEST-UTE sequence be reproducible and verifiable ex vivo, where pH measurements can be confirmed with a pH electrode. This study tested the reproducibility of the acidoCEST-UTE sequence in three ex vivo phantoms, confirming the pH sensitivity of the technique and demonstrating the consistency of the method and results. |
| 2799 | A two-stage Convolutional neural network for meniscus segmentation and tear classification | |
| Xing Lu1,2, Chang Guo1, Kai Zheng1, Dashan Gao2, Yunqiang Chen2, Haimei Chen1, and Yinghua Zhao1 | ||
1Department of Radiology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China, 212Sigma Technologies, San Diego, CA, United States |
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Artificial intelligence for interpreting MRI meniscal tear could prioritize high risk patients and assist clinicians in making diagnoses. In this study, a two-stage end-to-end convolutional neural network, with Mask rcnn as backbone for object detecting and Resnet for classification, is proposed for automatically detecting torn in the meniscus on MRI exams. With training dataset of 507 MR images and validation dataset of 69 MR images, the meniscus detection achieves a recall of 0.95 when 1 false positive of 1 image, and the ROC for classification of torn meniscus get a AUC of 0.99. |
| 2800 | High Angular Resolution Diffusion Imaging (HARDI) in Meniscus | |
| Nian Wang1, Gary Cofer1, Louis E. DeFrate2, Abigail Holt2, Amy L. McNulty2, Yi Qi1, Charles E. Spritzer1, and G. Allan Johnson1 | ||
1Department of Radiology, Duke University, Durham, NC, United States, 2Department of Orthopaedic Surgery, Duke University, Durham, NC, United States |
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Application of diffusion magnetic resonance imaging (dMRI) to map the complex collagen fibril structures of meniscus is still challenging, due to the short T2/T2* values, low fractional anisotropy (FA) values, and relatively low signal-to-noise (SNR). In this study, we imaged the porcine menisci in a preclinical 7 T system with relatively short echo time (TE ~ 11 ms). A 3D diffusion-weighted spin-echo pulse sequence was used for whole meniscus tractography at 125 µm isotropic resolution. |
| 2801 | Subtle Intensity Graduating Homomorphic Transform with a Small-percentage of Fat-saturation to Improve Conspicuity of Meniscal Tears at 7T | |
| Venkata Veerendranadh Chebrolu1,2, Peter Kollasch1,2, Eric G Stinson1,2, Andrew J Fagan2, Joel P Felmlee2, Benjamin M Howe2, Matthew A Frick2, and Kimberly K Amrami2 | ||
1Siemens Medical Solutions USA, Inc., Rochester, MN, United States, 2Department of Radiology, Mayo Clinic, Rochester, MN, United States |
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In this work, we propose the use of Subtle Intensity Graduating Homomorphic Transform (SIGHT) along with application of a small percentage of fat-saturation (fat-sat) to improve the conspicuity of meniscal tears at 7T. 2 musculoskeletal radiologists compared turbo-spin-echo (TSE) proton-density (PD)-weighted knee MRI (without fat-sat) with 12 different MRI options (TE, TR, fat-sat, field-of-view, and image-processing variations) for conspicuity of meniscal tears and rated 1st, 2nd and 3rd preferred options for each case. SIGHT image-processing applied to PD-weighted MRI along with a small percentage of fat-sat provided better conspicuity of meniscal tears than the regular PD- and T2-weighted MRI images. |
| 2802 | Magic Angle Directional Imaging (MADI) visualises changes to collagen fibre orientation in patellar tendons after freezing | |
| Karyn Elizabeth Chappell1, Mihailo Ristic2, Donald McRobbie3, Wladyslaw Gedroyc4, Djordje Brujic2, and Catherine Van Der Straeten5 | ||
1Medicine, Orthopaedic Surgery, Stanford University, Redwood City, CA, United States, 2Mechanical Engineering, Imperial College London, London, United Kingdom, 3University of Adelaide, Adelaide, Australia, 4Imperial College London, London, United Kingdom, 5Imperial College London/Ghent University, Ghent, Belgium |
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Does freeze/thaw of cadaveric specimens’ damage collagen fibre orientation? Magic angle directional imaging (MADI) in caprine knees assessed the underlying tissue structure before and after freezing for three and six weeks. Tendon thickness reduced after 6 weeks of freezing. Segmented collagen containing voxels decreased by half after freezing. Voids appeared in the internal tendon structure suggestive of ice crystal formation that disrupted collagen fibre orientation. The severity of the structural changes increased the longer the tissue was frozen. Interpreting results with frozen/thawed cadaveric specimens needs care as freezing damages collagen fibre structure that may impact on biomechanical and other properties. |
| 2803 | Magic Angle Directional Imaging (MADI) standard deviation maps correlate with knee pathology in a spontaneous injury model. | |
| Karyn Elizabeth Chappell1, Djordje Brujic2, Mihailo Ristic2, Donald McRobbie3, Wladyslaw Gedroyc4, Catherine Van Der Straeten5, and Richard Meeson6 | ||
1Medicine, Orthopaedic Surgery, Stanford University, Redwood City, CA, United States, 2Mechanical Engineering, Imperial College London, London, United Kingdom, 3University of Adelaide, Adelaide, Australia, 4Imperial College London, London, United Kingdom, 5Imperial College London/Ghent University, Ghent, Belgium, 6Royal Veterinary College, London, United Kingdom |
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A proof of concept study in a spontaneous ligament rupture dog model assessed if the magic angle effect disappears in unhealthy tissue. Ten dogs were scanned using the MADI technique. Standard deviation (SD) maps of signal intensity were computed and measured in an interactive display. Three subjects showed abnormally high SD; two at the ACL origin, one in the trochlear articular cartilage. Fibre orientation maps showed either disorganised or highly organised collagen fibres in these subjects. On dissection two subjects had partially torn ACLs and the other a fibrocartilage lesion. There was excellent correlation between the MADI and dissection findings. |
| 2804 | High-resolution 3T MRI of the dorsal and volar radioulnar ligament of the wrist | |
| Saya Horiuchi1,2, Hon Yu1, Toshimi Tando1, Taiki Nozaki2, and Hiroshi Yoahioka1 | ||
1Department of radiological sciences, University of California, Irvine, Irvine, CA, United States, 2Radiology Department, St. Luke's International Hospital, Tokyo, Japan |
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It is technically challenging to diagnose injuries to the radioulnar ligaments (RUL) of the wrist on magnetic resonance imaging (MRI). We identified and classified the morphology of the dorsal and volar radioulnar ligaments (RUL) of the wrist into five types using 3T MRI. Two hundred and nine participants were retrospectively evaluated using 3T axial 2D and reformatted axial isotropic 3D images. Both dorsal and volar RULs attach to the radial to dorsal side of the ulnar styloid. The RUL was equally identified on high-resolution two-dimensional and on isotropic three-dimensional MRI. |
| 2805 | The Angular Dependence of 3D Ultrashort Echo Time Cones Adiabatic T1ρ (3D UTE Cones-AdiabT1ρ) Imaging of the Achilles Tendon | |
| Mei Wu1,2, Mingxin Chen1, Yajun Ma1, Akhil Kasibhatla1, Lidi Wan1, Saeed Jerban1, Hyungseok Jang1, Eric Y Chang1,3, and Jiang Du1 | ||
1Department of Radiology, University of California, San Diego, San Diego, CA, United States, 2Department of Radiology, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China, 3Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States |
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This study investigated the magic angle effect in three-dimensional ultrashort echo time Cones Adiabatic T1ρ (3D UTE Cones-AdiabT1ρ) imaging of the Achilles tendon on a clinical 3T scanner. The magic angle effect was investigated by repeated UTE Cones-AdiabT1ρ imaging of five human Achilles tendon samples at five angular orientations ranging from 0° to 90° relative to the B0 field. Conventional Cones continuous wave T1ρ (Cones-CW-T1ρ) and Cones-T2* sequences were also applied for comparison. Cones-AdiabT1ρ showed a much reduced magic angle effect as compared to regular Cones-CW-T1ρ and Cones-T2*, suggesting its potential use as a novel biomarker for musculoskeletal (MSK) imaging. |
| 2806 | Quantitative ultrashort echo time (UTE)-Cones monitoring of tendon healing after arthroscopic rotator cuff repair (ARCR) surgery | |
| xue yu xie1, puye wu2, and shuang chen3 | ||
1radiology, huashan hospital, shanghai, China, 2GE healthcare, beijing, China, 3huashan hospital, shanghai, China |
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A longitudinal monitoring of the supraspinatus tendon healing during the first year after arthroscopic rotator cuff repair (ARCR) surgery using quantitative ultrashort echo time (UTE)-Cones. |
| 2807 | The influence of the knee position on vTE-T2* values of patellar- and quadriceps tendon measured at 3T and 7T | |
| Benedikt Hager1,2, Markus M. Schreiner3, Vladimir Mlynarik1, Vladimir Juras1, Xeni Deligianni4,5, Oliver Bieri4,5, Reinhard Windhager3, and Siegfried Trattnig1,2 | ||
1Department of Biomedical Imaging and Image-guided Therapy, High Field MR Centre, Medical University of Vienna, Vienna, Austria, 2CD Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 3Department of Orthopaedics and Trauma Surgery, Medical University of Vienna, Vienna, Austria, 4Department of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, Switzerland, 5Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland |
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In our study in which we used a variable echo-time sequence for T2*-mapping of tendons in vivo at 3T and 7T, we showed that even small changes in the knee position in the knee coil can lead to significant changes in the T2*-values of the patellar tendon and quadriceps tendon. We have also shown that the T2*-values of the tendons correlate well with the angle of the bulk of the collagen fibers to the magnetic field. Based on these results, we recommend that for T2*-mapping it is important to examine the tendon in exactly the same position in the follow-up. |
| 2808 | Volumetric tendon segmentation using ultra-short echo-time (UTE) imaging and bivariate relaxation parameter-based histogram analysis | |
| Martin Krämer1, Marta B Maggioni1, and Jürgen R Reichenbach1 | ||
1Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany |
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Segmentation of tendons based on MRI data is challenging because of their very short transverse relaxation times and typically curved structure as well as small diameter. In this work, we performed combined T2* and T1 mapping using multi-echo and variable flip angle ultra-short echo-time imaging. Based on the resulting relaxation parameter maps, bivariate histograms were calculated which showed distinct clusters that could be ascribed to various tissues. Ranges for both relaxation parameters were defined using these histograms and applied to volumetrically segment and subsequently visualize the patellar and quadriceps tendon. |
| 2809 | Ultrashort echo time adiabatic T1ρ (UTE-Ad-T1ρ) can predict the mechanical property differences in human anterior cruciate ligament (ACL) | |
| Saeed Jerban1, Takehito Hananouchi2, Yajun Ma1, Erik Dorthe3, behnam namiranian1, Jonathan Wong4, Mei Wu1, Darryl D'lima3, Eric Y Chang4, and Jiang Du1 | ||
1Radiology, University of California, San Diego, San Diego, CA, United States, 2Department of Mechanical Engineering, Osaka Sangyo University, Daito, Osaka, Japan, 3Shiley Center for Orthopedic Research and Education at Scripps Clinic, La Jolla, CA, United States, 4Research Service, VA San Diego Healthcare System, San Diego, CA, United States |
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Clinical MRI techniques typically show the anterior cruciate ligament (ACL) as low in signal. Commonly used quantitative MRI techniques are sensitive to tissue orientation and magic angle effect. A recently developed ultrashort echo time (UTE)-based adiabatic T1ρ technique (UTE-Ad-T1ρ) can detect high signal in the ACL and may be less sensitive to magic angle effect. We have investigated for the first time the correlation between UTE-Ad-T1ρ and ACL mechanical properties. T1ρ showed significant strong correlation with average elastic modulus of ACL specimens. The UTE-Ad-T1ρ technique is highlighted as a potential tool to noninvasively assess the ACL mechanical properties. |
| 2810 | Comparison of Meniscal T2* Metrics in Elite Basketball Players and Swimmers | |
| Erin C Argentieri1, James C Yoder1, Garry Gold2, Sharmila Majumdar3, Matthew F Koff1, and Hollis G Potter1 | ||
1Radiology and Imaging, Hospital for Special Surgery, New York, NY, United States, 2Stanford University, Stanford, CA, United States, 3University of California San Francisco, San Francisco, CA, United States |
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As basketball players represent a population with an inherently high risk of sustaining meniscal injuries, studying how basketball play can lead to changes in the meniscus is of clinical importance. To date, no studies have been performed to evaluate T2* values of the meniscus in high performance athletes. Therefore, the purpose of this study was to utilize ultra-short TE (UTE) MRI to compare meniscal T2* values between basketball players and swimmers. Significant differences of T2* values were found between the medial and lateral menisci. No significant difference of meniscal T2* values were found between basketball players and swimmers. |
| 2811 | Pre- to post-ovulatory changes in ACL T2* metrics over the course of the female menstrual cycle: A new biomarker for ACL injury risk? | |
| Erin C Argentieri1, Tatum W Braun1, Ryan E Breighner1, Bin Q Lin2, Ellen K Casey3, Shari T Jawetz1, Alissa J Burge1, Matthew F Koff1, and Hollis G Potter1 | ||
1Radiology and Imaging, Hospital for Special Surgery, New York, NY, United States, 2Biostatistics, Hospital for Special Surgery, New York, NY, United States, 3Physiatry, Hospital for Special Surgery, New York, NY, United States |
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This study evaluates changes in ACL T2* metrics over the course of the female menstrual cycle. In the pre-ovulatory phase, normally ovulating case subjects demonstrated significant shortening of T2*S and PS in comparison to visit #4 (post-ovulatory phase). Non-ovulatory control subjects displayed no significant changes over time. These findings suggest that shifts in collagen bound water occur within the ACL over the course of the menstrual cycle. Shifts in tissue water content have been associated with altered mechanical properties, and changes in ligament stiffness may alter proprioceptive sense, contribute to increases in laxity, and alter ACL-injury risk. |
| 2812 | Compression of nerve root causes high degree of fat infiltration of lumbar multifidus muscle | |
| Hui Hao1, Jia Yin Tong1, Xiao Cheng Wei2, and Jian Yang1 | ||
1Department of Radiology, the First Affiliated Hospital, Xi'an Jiaotong University, xi'an, China, 2MR Research China, GE Healthcare, Bei Jing, China |
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The increase of multifidus muscle fat infiltration will affect the postoperative rehabilitation of patients with lumbar spine surgery. In this study, reasons for fat infiltration on both sides of multifidus muscles were analyzed retrospectively. Through Priffman grading evaluating the intervertebral disc and Kader grading for fat infiltration, a retrospective analysis was conducted on 453 cases of intervertebral discs images. In our study, nerve root compression was found to be correlated with degree of multifidus muscle fat infiltration. This correlation support the hyposis that nerve root compression would result in an increase in the adiposity of multifarious muscles. |
| 2813 | Stirring STIR contrast | |
| Nick Zafeiropoulos1, Stephen Wastling1, Jasper Morrow2, Uros Klickovic1, Pietro Fratta1, Sachet Shah1, Enrico De Vita3, Mary M Reilly2, Tarek Yousry1, and John Thornton1 | ||
1UCL Queen Square Institute of Neurology, London, United Kingdom, 2MRC Centre for Neuromuscular Diseases, London, United Kingdom, 3King's College London, London, United Kingdom |
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In vivo lower-limb STIR images were compared with images simulated using a theoretical signal model with experimentally determined muscle-water T2 and fat fraction values. Nominally T2-weighted STIR contrast is seen to depend on changing tissue-water relative proton density as fat content increases in diseased muscle, in addition to expected T2 dependent changes. Imperfect inversion-recovery fat nulling may also cause unexpected hyper-intensity in regions of high fat content. These observations may have implications for the clinical interpretation of STIR signal intensity. |
| 2814 | Dynamic multinuclear measurements in the calf with a dedicated RF coil while taking into account the nuclear Overhauser enhancement effect. | |
| Alfredo Liubomir Lopez Kolkovsky1,2, Benjamin Marty1,2, Marc Lapert3, Eric Giacomini1, and Pierre G Carlier1,2 | ||
1NMR Laboratory, Institute of Myology, Paris, France, 2NMR Laboratory, CEA/DRF/IBFJ/MIRCen, Paris, France, 3Siemens Healthcare SAS, Saint-Denis, France |
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Interleaving multinuclear NMR measurements in the muscle during a transient state enriches the value of the exam by generating multiple data sets simultaneously. Here we show the results of our multinuclear interleaved approach using a 1H/31P dual-tune RF coil dedicated for calf experiments during an exercise and an ischemia-hyperemia paradigm. The nuclear Overhauser enhancement effect, which is dependent on the sequence and RF design, is characterized and its impact on rephosphorylation rate estimation and the [Pi]/[PCr] ratio is evaluated. The proposed methodology constitutes a powerful tool to evaluate mitochondrial function and metabolic efficiency in vivo. |
| 2815 | MRI of the knee during weight-bearing standing postures involving positions of joint extension and flexion | |
| YueFen Zou1, Yu Zheng1, HongYuan Ding1, SiSeung Kim2, Shekhar Suresh Chandra3, Jurgen Fripp4, Jian Bao2, HuiYao Zhang2, Bing Keong Li2, and Craig Engstrom 5 | ||
1Medical Imaging, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2Jiangsu LiCi Medical Device Co. Ltd, LianYunGang, China, 3ITEE, The University of Queensland, Brisbane, Australia, 4The Australian e-Health Research Centre, CSIRO, Brisbane, Australia, 5School of Human Movement & Nutrition Science, The University of Queensland, Brisbane, Australia |
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Standing weight-bearing MR images of the knee joint in full extension and at various flexion angles (~15°, 30°) were acquired using 2D and 3D sequences on a newly developed open 0.25T extremity MRI system. 3D FLASH images were used to calculate measures of patella positioning used in previous clinical investigations as well as to produce MRI-based 3D bone models. The use of MRI and 3D modeling for topographical analyses of the bones and soft-tissues of the knee joint have the potential to provide more detailed assessment of pathoanatomical conditions involving structures such as the patella tendon and the menisci. |
| 2816 | Immersion of ex vivo Achilles tendon in phosphate buffered saline influences their T1 and T2* relaxation times | |
| Martin Krämer1, Matthias R Kollert2,3, Nicholas M Brisson2, Marta B Maggioni1, Georg N Duda2,3, and Jürgen R Reichenbach1 | ||
1Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, 2Julius Wolff Institute and Center for Musculoskeletal Surgery, Charité – Universitätsmedizin Berlin, Berlin, Germany, 3Berlin-Brandenburg Center and School for Regenerative Therapies, Charité – Universitätsmedizin Berlin, Berlin, Germany |
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Controlling tissue integrity and hydration levels is a crucial step when preparing and measuring ex vivo samples of tendons. In this work, we immersed ex vivo Achilles tendons in phosphate buffered saline solution and measured T1 and T2* relaxation times at baseline, 30 h and 67 h after immersion using 3D ultra-short echo-time imaging with variable flip angles and echo-train shifted multi-echo acquisition, respectively. Results based on regions-of-interest in mid-tendon and enthesis areas showed a significant increase in both T1 and T2* after 30 h of immersion in the phosphate buffered saline solution. |
| 2817 | A three compartment complex signal model to describe the signal decay of ultrashort T2* tissues applied to ex vivo ovine Achilles tendons | |
| Marta Brigid Maggioni1, Martin Krämer1, and Jürgen R. Reichenbach1,2,3,4 | ||
1Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University, Jena, Germany, 2Michael Stifel Center for Data-driven and Simulation Science Jena, Friedrich Schiller University, Jena, Germany, 3Abbe School of Photonics, Friedrich Schiller University, Jena, Germany, 4Center of Medical Optics and Photonics, Friedrich Schiller University, Jena, Germany |
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Tendons are highly ordered tissues, mainly composed of collagen, and characterized by very short transverse T2* relaxation times. Even when using ultra-short echo-time imaging sequences, quantification of T2* is challenging as the origin and characteristics of the signal decay in tendons is still under debate. In this work, we finely sampled the decay of the transverse magnetization using an echo-train shifted multi-echo ultra-short echo-time sequence with 55 echoes and applied a complex tri-exponential model to extract T2* constants. |
| 2818 | Fat suppression in 3D Quantitative Ultrashort Echo Time Cones (qUTE-Cones) imaging | |
| Yanjun Chen1,2, Zhenyu Cai2, Liang Li2, Carolyn Xie2, Michael Carl3, Eric Y Chang4, Jiang Du2, and Yajun Ma2 | ||
1The Third Affiliated Hospital of Southern Medical University, Guangzhou, China, 2UC San Diego, San Diego, CA, United States, 3GE healthcare, San Diego, CA, United States, 4VA health system, San Diego, CA, United States |
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Strong fat signal contamination leads to significant errors in quantitative UTE (qUTE) imaging of musculoskeletal tissue. In this study, we used a fat suppression technique to investigate whether fat signals could be sufficiently suppressed in qUTE imaging and whether the fat saturation preparation would affect the resultant qUTE measures due to the induced water attenuation. |
| 2819 | Effect of room temperature storage on relaxation properties of ex vivo articular cartilage | |
| Olli Nykänen1, Nina Hänninen1,2, and Mikko J Nissi1,2 | ||
1Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 2Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland |
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Typical measurement protocols for quantitative MRI of ex vivo osteochondral samples may last hours when multiple parameters with high resolution are measured. However, knowledge about the changes in the relaxation properties of articular cartilage during long scans is inadequate. In this study, we measured T1, adiabatic T1rho and T2-relaxation times for two osteochondral samples directly after sample preparation and repeated the measurements after 15 hours of storage at room temperature. T1-relaxation time decreased noticeably at later timepoint while adiabatic T1rho and T2-relaxation times remained the same. Due to small sample size, statistical significance of the results could not be verified. |
| 2820 | T1ρ imaging in 7T: evaluation of high dielectric pad for SAR reduction | |
| Jeehun Kim1,2, Wanyong Shin2,3, Mei Li1,2, and Xiaojuan Li1,2,3 | ||
1Biomedical Engineering, Cleveland Clinic, Cleveland, OH, United States, 2Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, United States, 3Department of Diagnostic Radiology, Cleveland Clinic, Cleveland, OH, United States |
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To fully utilize the superior signal-to-noise ratio of 7T MRI for cartilage T1ρ imaging, high specific-absorption ratio (SAR) needs to be accounted for. Previous researches showed the use of high dielectric pad could substantially decrease the SAR in 7T MRI. In this work, the effect of the use of high dielectric pad on T1ρ imaging in terms of SAR level and T1ρ relaxation time quantification. |
| 2821 | Resolving the Complex Fiber Structures in Knee Joint Using High Resolution Diffusion Imaging | |
| Nian Wang1, Anthony J. Mirando2, Gary Cofer1, Yi Qi1, Matthew J. Hilton2, and G. Allan Johnson1 | ||
1Department of Radiology, Duke University, Durham, NC, United States, 2Department of Orthopaedic Surgery, Duke University, Durham, NC, United States |
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Using high-order diffusion tractography to map the complex collagen fibril structures in knee joint is still challenging, due to the limited spatial resolution, low angular resolution, and low signal-to-noise (SNR). The complex fiber distributions in different connective tissues in knee joint were investigated using high resolution diffusion imaging. |
| 2822 | Histogram analysis of T2* value for lumbar intervertebral disc degeneration | |
| Xiaoqing Liang1, Ruyi Xie1, Yitong Li1, Bowen Hou1, Weiyin Vivian Liu2, and Xiaoming Li1 | ||
1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2MR Research,GE Healthcare, Beijing, China |
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Low back pain (LBP) is a common spinal disease during the middle-to-old-aged population. Degeneration of lumbar intervertebral discs (IVDs) is recognized as the common and crucial cause of LBP. Histogram analysis is a recently popular method for assessing microstructural heterogeneity, however, its diagnostic performance in intervertebral disc degeneration hasn’t been proved. Histogram analysis on axial T2* mapping was applied to characterize degenerative degrees and heterogeneity of discs. All histogram parameters of T2* value were significantly related to Pfirrmann grading. Our study confirmed that the apparent “red zone” on T2* color maps was clearly related to degeneration. |
| 2823 | Diffusion kurtosis imaging and intravoxel incoherent motion in quantitative evalutation of lumbar intervertebral disc degeneration | |
| Feifei Zeng1, Yunfei Zha2, and Weiyin Liu3 | ||
1Radiology, Renmin Hospital of Wuhan University, Wuhan, China, 2Renmin Hospital of Wuhan University, Wuhan, China, 3MR Research, GE Healthcare, Bejing, China |
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The purpose of this study is to compare the diagnostic value of diffusion kurtosis imaging (DKI) and intravoxel incoherent motion(IVIM) in assessing lumbar intervertebral disc degeneration. DKI parameters ( MK, MD, and FA), and IVIM parameters (ADCstandard, ADCslow, ADCfast, and f) of nucleus pulposus (NP), anterior annulus fibrosus (AAF) and posterior annulus fibrosus (PAF) were measured and correlated with Pfirrmann grades. It was found that DKI and IVIM parameters had significantly correlation with Pfirrmann grades. In addition, DKI was more sensitive than IVIM in quantitative detection of early lumbar intervertebral disc degeneration. |
| 2824 | Imaging Cartilaginous Endplates Herniation in the Lumber Spine using ZTE-MRI | |
| Yen-Chang Chen1, Chien-Yuan Lin1, Ching-Wei Gu2, Yu-Hsin Tang2, Wei-Min Hung2, Yi-Chih Hsu2, and Guo-Shu Huang2 | ||
1GE Healthcare, Taipei, Taiwan, 2Department of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan |
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The cartilage endplate (CEP) plays an important role in the function and homeostasis of the intervertebral disc by serving as a mechanical stabilizer as well as a pathway for nutrient transport. There is a very little known about CEP due in part to the lack of suitable imaging technique to evaluate the CEP. The purposes of this study were to optimize the parameters of zero echo time (ZTE) MRI in enhancing CEP structure and then to evaluate the morphology of CEP in lumbar spine with herniation of disc using ZTE-MRI. |
| 2825 | Real-time Imaging of the TMJ: Comparison of Methods | |
| Kilian Stumpf1, Patrick Metze1, Tobias Speidel1, Thomas Hüfken1, and Volker Rasche1 | ||
1Department of Internal Medicine II, University Medical Center Ulm, Ulm, Germany |
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Disorders of the temporomandibular joint (TMJ), such as pain and blockage, usually arise while the joint is in motion. Capturing this dynamic process requires high temporal resolutions and good contrast between condyle and articular disk, which is possible with advanced sequences that often need sophisticated reconstruction algorithms. In this contribution, the widely available or easily implemented and reconstructed TSE-Zoom sequence was compared to advanced radial and spiral sequences employing uniform and tiny golden angle(tyGA) profile ordering. While tyGA sequences allow fluid rendering of the joint motion, TSE-Zoom can be considered a viable alternative with excellent contrast between condyle and disk. |
| 2826 | INCREASED PREVALENCE OF FEMOROACETABULAR IMPINGEMENT ANATOMY AMONG ATHLETES WHO TREAD WATER | |
| Joanna Lind Langner1, Marianne Black1, James MacKay2, Kimberly Hall3, Marc Safran3, Feliks Kogan1, and Garry Gold1 | ||
1Radiology, Stanford University, Stanford, CA, United States, 2Cambridge University, Cambridge, United Kingdom, 3Stanford University, Stanford, CA, United States |
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Femoroacetabular impingement (FAI) is a disorder that causes hip pain and disability in young patients, particularly athletes. Treading water leads to increased stress on the hip, the effects of which are poorly understood. In this study, we used MRI to identify the prevalence of FAI anatomy in elite aquatic athletes that tread water. The prevalence of cam FAI was higher than that previously reported for any other sport. This study demonstrates that synchronized swimmers and water polo athletes are at increased risk of cam FAI, more than other sports. |
| 2827 | Trabecular Bone Microarchitecture: A Comparative Analysis between High Field, Ultra High Field MRI and X-ray micro CT in human anatomical samples | |
| Enrico Soldati1, Martine Pithioux2, David Bendahan3, and Jerome Vicente1 | ||
1IUSTI, AixMarseille, Marseille, France, 2ISM, AixMarseille, Marseille, France, 3CRMBM, AixMarseille, Marseille, France |
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It has been previously suggested that trabecular bone could be assessed using ultra-high and high-field MRI. In the present study, human femurs head were scanned using with MRI at 3T and 7T MRI and the corresponding metrics were compared to those obtained using high resolution X-ray micro tomography. |
| 2828 | Feasibility of Rapid MRI Assessment of Leg Alignment | |
| Feliks Kogan1, Scott Uhlrich2, Madeleine Berkson3, Akshay Chaudhari1, Marianne Black1, Valentina Mazzoli1, Lauren Watkins1, Garry E Gold1, and Brian Hargreaves1 | ||
1Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Mechanical Engineering, Stanford University, Stanford, CA, United States, 3Palo Alto Veterans Affairs Hospital, Palo Alto, CA, United States |
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Varus and valgus alignment are associated with the presence and progression of knee osteoarthritis. We assessed the feasibility of rapidly assessing leg alignment with a non-weight bearing MRI in under a minute. Good agreement was observed between alignment measurements from MRI and weight-bearing radiographs. This technique offers a sub-one-minute scan that can be incorporated into routine MRI knee scans to add important knee alignment information and potentially removes the need for additional scanning. |
| 2829 | A rat model of periprosthetic joint infection (PJI) using 3D printed titium hip implants: Ultrashort echo time (UTE) MRI at 7T | |
| Mariam Taha1,2, Greg O. Cron1,3,4, Gerd Melkus3,4, Peder E.Z. Larson5, Mazen Ibrahim2, Adam D.M. Paish6,7, Yusra Al Mosuli1,2, William Hadden2, David Holdsworth6,7, and Hesham Abdelbary2 | ||
1Ottawa Hospital Research Institute, Ottawa, ON, Canada, 2Orthopedic Surgery, The Ottawa Hospital, Ottawa, ON, Canada, 3Medical Imaging, The Ottawa Hospital, Ottawa, ON, Canada, 4Radiology, University of Ottawa, Ottawa, ON, Canada, 5Radiology, University of California at San Francisco, San Francisco, CA, United States, 6Western University, London, ON, Canada, 7Robarts Research Institute, London, ON, Canada |
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Two to fourteen percent of primary total joint replacement cases develop periprosthetic joint infection (PJI), a devastating complication. PJI animal models for hip and knee are required to evaluate prevention and treatment methods. We developed a novel rat model for PJI using a 3D printed titanium hip implant. Implant stability in the rats was monitored with 7T MRI using Ultrashort Echo Time (UTE) imaging and classical spin echo imaging. UTE demonstrated superior image quality compared to spin echo imaging. This rat model will provide a unique opportunity to validate and study strategies focusing on the prevention and treatment of PJI. |
| 2830 | Using Compressed Sense Technique for Lumbar Vertebra Imaging: Comparison with Conventional Parallel Imaging | |
| Tianyang Gao1, Shinong Pan1, Zhao Lu1, Fengzhe Wang1, and Jiazheng Wang2 | ||
1Shengjing Hospital of China Medical University, Shenyang, China, 2Clinical Science, Philips Healthcare, Beijing, China |
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SENSE-TSE is widely used in routine joint scanning, which requires a considerable length of scan duration. Staying in the same position for a long time inevitably causes discomfort and unwanted movement of patients, resulting in image quality degradation. Therefore, shortening imaging time to reduce motion artifacts has become an important goal in the application of CS acceleration in clinical practice.This study aims to retrospectively compare the image quality and diagnosis accuracy of CS-TSE and SENSE-TSE in lumbar vertebra MRI. |
| 2831 | The evaluation of the metal artifact and SNR changes in multiple fat-suppression techniques：a phantom study | |
| Xu Lulu1, Qi Liang1, Dou Weiqiang2, and Shen Yong3 | ||
1Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2MR Research China, GE Healthcare, Beijing, China, 3Enhanced MR application, GE Healthcare, Beijing, China |
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Finding the most suitable fat-suppression technique when acquiring the images with titanium alloy, the phantom was studied. We found the STIR was most potent when comparing the other methods. This result may provide the reference value when we offer the patients with metallic hardware after surgery with the proper fat-suppression technique. |
| 2832 | Study on the optimization of BOLD magnetic resonance ischemia-reactive hyperemia model of skeletal muscle of calf | |
| Chunye Geng1 and Jianling Cui1 | ||
1The Third Hospital of Hebei Medical University, Shijiazhuang, China |
||
In BOLD-MRI studies, cuff compression was often used to establish the ischemia-reactive hyperemia model of calf muscle.We found some BOLD signals did not decrease during ischemia, but increased or stay the same.This study was to find the reasons why BOLD signal showed multiple trends in ischemic period and to optimize the ischemia model. BOLD scan was performed on volunteers under two cuff pressures.BOLD signals of all muscles showed a downward trend in the P1 model of partly reduced blood supply. However, in P2 model of blood supply blocked completely, BOLD signals had mostly gone up during ischemia ,unexpectedly. |
| 2833 | Evaluation of Knee Osteoarthritis (OA) Using 3D Ultrashort-Echo-Time Cones Magnetization Transfer (3D UTE-Cones-MT) Imaging | |
| Xiaodong Zhang1,2, Ya-jun Ma2, Aria Ashir2, Mei Wu2, Zhao Wei2, Eric Y Chang3, and Jiang Du2 | ||
1The third affilated hospital of Southern Medical Univerisity, Guangzhou, China, 2Department of Radiology, University of California, San Diego, CA, United States, 3Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States |
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Magnetization transfer (MT) imaging has been used for indirect assessment of macromolecules in biological tissues. In this study, we explore the value of the 3D UTE-Cones-MT sequence for volumetric quantification of magnetization transfer ratio (MTR) and macromolecular proton fraction（f） in menisci of healthy volunteers and patients with different degrees of OA. The primary results demonstrate that this method can detect compositional changes in meniscus and can be used to differentiate healthy subjects from patients with mild or advanced OA. |
| 2834 | Phase-cycling diffusion-sensitized driven-equilibrium (pcDSDE) for MR neurography of the crus | |
| HAJIME YOKOTA1, TAKAYUKI SAKAI2, MASAMI YONEYAMA3, AKIYO TAKADA4, and TAKASHI UNO1 | ||
1Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan, 2Radiology, Eastern Chiba Medical Center, Togane, Japan, 3Philips Japan, Tokyo, Japan, 4Radiology, Chiba University Hospital, Chiba, Japan |
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MR neurography for the crus is challenging because signals of the vessels and subcutaneous edema interrupt visualization of the nerve, and the water content of the nerve is small. Phase-cycling diffusion-sensitized driven-equilibrium (pcDSDE) can reduce signals of the neighboring structures including the vesssels, and visualize the nerves with diffusion contrast. pcDSDE was better than 3D-NerveVIEW for visualizing the tibial and sural nerves in the crus. The contrast ratio between the tibial nerve and neighboring muscle was significantly higher on pcDSDE than on 3D-NerveVIEW in both the proximal and distal crura. |
| 2835 | Can Accelerated SEMAC TSE Replace Conventional TSE in the Spine? | |
| Ali Rashidi1, Shivani Ahlawat1, Rodrigo Luna1, and Jan Fritz1 | ||
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States |
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We investigated the exchangeability of accelerated SEMAC TSE and high-bandwidth TSE MRI in patients with spinal hardware. Two musculoskeletal radiologists found through quantitative and qualitative evaluations of 50 patients with cervical, thoracic, and lumbar spinal instrumentation that accelerated SEMAC resulted in fewer metal artifacts, better visibility of anatomical structures and abnormalities, only mildly increased blur and similar soft tissue and bone contrasts. In the spine, accelerated SEMAC TSE can be used as a replacement, rather than “add-on”, of high-bandwidth TSE. |
| 2836 | Investigating relationship between creatine kinase kinetics and total NAD levels in human skeletal muscle in vivo using 31P MRS at 7.0T | |
| Deepa Thakuri1, Puneet Bagga1, Dushyant Kumar1, and Ravinder Reddy1 | ||
1Radiology, University of Pennsylvania, philadelphia, PA, United States |
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Nicotinamide adenine dinucleotide (NAD) plays an important role in cellular metabolism and it is important to study its correlation with other metabolites of the skeletal muscle. Phosphocreatine (PCr) present in abundant amount in the skeletal muscle facilitates the generation of ATP by conversion into creatine. 31P-MRS is a common technique used to study PCr recovery kinetics and its application has been shown in various diseases related to mitochondrial disorders. In this study, we aim to investigate the relationship between PCr recovery kinetics, total NAD concentration, and age. |
| 2837 | Assessment of skeletal muscle pathology in Dystrophin-deficient mice using structural and functional Diffusion MRI | |
| Rina Ito1,2, Junichi Hata3,4, Mayu Iida1,2, Fumiko Seki2, Mitsuki Rikitake1,2, Yuji Komaki2, Chihoko Yamada2, Daisuke Nakashima4, Hirotaka James Okano3,4, and Takako Shirakawa1 | ||
1Department of Radiology, Faculty of Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, 2Live Imaging Center, Central Institute for Experimental Animals, Kanagawa, Japan, 3Jikei University School of Medicine, Tokyo, Japan, 4Keio University School of Medicine, Tokyo, Japan |
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To analyze the disease of muscular dystrophy noninvasively, we assessed the degeneration of skeletal muscle and the distinction depending on types of muscle fibers, with changing parameters based on the sequence of diffusion weighted imaging. The mdx mice were used for longitudinal evaluation at the age from 5 to 10 weeks. We confirmed conventional diffusion tensor imaging could evaluate the pathological structure. Moreover, by applying the advanced imaging such as time-dependent diffusion MRI, we could demonstrate the functional characteristics of skeletal muscle cell and to detect micro-level condition of degeneration in mdx-mice. |
| 2838
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Osteochondral Junction Imaging Using Adiabatic Inversion Recovery Prepared Fat-Saturated Zero Echo Time MR Imaging: A Feasibility Study | |
| Hyungseok Jang1, Yajun Ma1, Michael Carl2, Saeed Jerban1, Eric Chang1,3, and Jiang Du1 | ||
1University of California, San Diego, San Diego, CA, United States, 2GE Healthcare, La Jolla, CA, United States, 3VA San Diego Healthcare System, San Diego, CA, United States |
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Cartilage has a complex structure comprised of multiple zones with different MR signal properties. Among them, osteochondral junction (OCJ) cannot be directly imaged with conventional MR imaging techniques. In this study, we explore the feasibility of inversion recovery prepared fat-saturated zero echo time (IR-FS-ZTE) to image the human knee OCJ. To accentuate the signal from the OCJ region with short T2*, adiabatic inversion recovery along with fat-saturation preparation was applied, followed by continous, slient ZTE imaging. The feasibility and efficacy of IR-FS-ZTE were shown in ex vivo cadaveric human knee joints and in in vivo healthy volunteers. |
| 2839 | 23Na MRI of human intervertebral cervical discs in Mucopolysaccharidosis type II | |
| Lenka Minarikova1, Alena Svatkova2, Wolfgang Bogner1, Siegfried Trattnig1,3, Thomas Stulnig2, and Stephan Gruber1 | ||
1High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Clinical Division for Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria, 3CD Laboratory for Clinical Molecular MR Imaging, Vienna, Austria |
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Spinal skeletal disease is one of least therapy responding symptoms in MPS patients. Cervical spine of three MPS II patients and three matched controls was measured using 23Na MRI at 7T. There was a significant difference in intervertebral discs of MPS II patient compared to controls. 23Na MRI represents a potential quantitative method for assessment of cervical disc degeneration in MPS II patients and could serve as a potential marker used in monitoring of emerging therapies. |
| 2840 | Gadolinium deposition in cortical Bone after repeated administration of Magnevist and Gadovist assessed by ultrashort echotime based T1 mapping | |
| Kaixuan Zhao1, Shisi Li2, Keyan Yu2, Jian Wang2, Xiaodong Zhang2, Qinqin Yu2, Cuiling Zhu2, Yingjie Mei3,4, Pu Xu3, Peiwei Yi3, Jiang Du5, and Yanqiu Feng3 | ||
1Southern Medical University, Guang Zhou, China, 2Imaging department of Southern Medical University affiliated the third hospital, Guang Zhou, China, 3School of Biomedical Engineering, Guangdong Provincial Key Laborary of Medical Image Processing, Southern Medical University, Guang Zhou, China, 4Philips Healthcare, Guang Zhou, China, 5Department of Radiology, University of California San Diego, San Diego, CA, United States |
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In this preclinical study, we assessed feasibility of evaluating Gadolinium deposition in cortical bone by using recently developed actual flip angle variable repetition time 3D ultrashort echotime technique in rabbit model at 7T. Twenty times of administration of clinical equivalent dose of Magnevist and Gadovist that normalized according to body surface by U.S. FDA recommendation, and three times the dose of Gadovist (high-dose group) were investigated. Significant lower T1 values were observed in Magnevist administration group, Gadovist administration group and high-dose Gadovist administration group compared to control group, suggested T1 mapping might be a potential biomarker for evaluating Gadolinium deposition. |
| 2841 | Bilateral Sodium Magnetic Resonance Imaging of the Lower Extremity | |
| Dimitri Alexander Kessler1, Mary A McLean2, Titus Lanz3, Frank Riemer4, Rolf F Schulte5, Andrew Grainger1, Fiona J Gilbert1, Martin J Graves1, and Joshua D Kaggie1 | ||
1Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 2Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 3Rapid Biomedical GmbH, Rimpar, Germany, 4Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital Helse Bergen, Bergen, Norway, 5General Electric Healthcare, Munich, Germany |
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We present a method for bilateral sodium magnetic resonance imaging (MRI) of the lower extremities. Sodium MRI can provide direct information on tissue biochemistry not available through standard proton MRI, and could therefore potentially assist in disease diagnosis. Our preliminary results demonstrate the application of large field-of-view sodium MRI to the musculoskeletal system for potential compositional assessment of multiple tissues in both legs including muscle, cartilage, synovium and arteries. |
| 2842 | Initial Assessment of a novel hybrid ultrashort echo time (UTE) sequence | |
| Lumeng Cui1, Emily J McWalter1,2, Gerald Moran3, and Niranjan Venugopal4 | ||
1Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, 2Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, 3Siemens Healthcare Limited, Oakville, ON, Canada, 4Department of Radiotherapy Physics, CancerCare Manitoba, Winnipeg, MB, Canada |
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Ultrashort echo time (UTE) pulse sequences have the unique ability to visualize short T2 tissues. While several UTE techniques have been implemented and demonstrated good clinical results, there currently does not exist a flexible and robust UTE pulse sequence which can easily manipulate multiple parameters “on-the-fly“ (i.e. selection of trajectories, excitation pulses, acquisition parameters, etc.), and obtain several complimentary scans in a single scan session. In this work we present a newly developed hybrid UTE pulse sequence that includes multiple excitation pulses, and varying trajectories, allowing for novel investigations in studying short T2 tissues. |