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| S9 | Accuracy of measurements of flow velocity using compressed sensing in 3D cine phase-contrast MRI - Experiments using a steady-flow pump and blood-mimicking flow phantoms - | |
| Atsushi Fukuyama1, Katsuhiro Inoue2, Shinichi Takase2, Tsunehiro Yamahata2, Yutaka Kato3, and Shuji Koyama4 | ||
1Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Mie University Hospital, Tsu, Japan, 3Nagoya University Hospital, Nagoya, Japan, 4Brain & Mind Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan |
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Compressed sensing (CS) is a technique that applies image compression theory to reconstruct an image from unusually sparse data that is used to infer the remaining data. CS is similar to parallel imaging technique, another technology that reduces imaging time. However, in case of the former, there is no reduction in the signal-to-noise ratio. In recent years, several studies have been conducted with the goal of reducing burden on patients by using the CS technique that can measure flow velocity in four dimensions (the three dimensions + time). |
| S3 | Clinical MRI protocol used for patients with cerebrovascular diseases | |
| Helle Juhl Simonsen1, Ulrich Lindberg2, Karina Elin Segers3, Bente Sonne Møller3, and Henrik B.W. Larsson2 | ||
1Functional Imaging Unit Dept. of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Glostrup, Hvidovre, Denmark, 2Functional Imaging Unit, Dept. of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Glostrup, Glostrup, Denmark, 3Department of Radiology, Rigshospitalet, Glostrup, Glostrup, Denmark |
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To investigate the cerebral blood flow, patients with Cerebrovascular Disease have previously been referred for a single-photon-emission-computed-tomography scanning with/ maybe without Diamox (a vasodilator). If the patient has perfusion defects on the first SPECT scanning with Diamox, the patient must undergo a new SPECT scanning without Diamox to determine whether the flow defects are due to reduced flow reserve. It is time-consuming examinations in which the patient receives gamma radiation from administered radioactive drug. To prevent patients going through two long examinations and to get a more detailed examination of the cerebrovascular defects, we have set-up a clinical MRI protocol. |
| S6 | How to improve your image quality when scanning young children. | |
| Helle Juhl Simonsen1, Karina Elin Segers2, Eduardo Hansen2, Mads Rostock2, and Ulrich Lindberg1 | ||
1Functional Imaging Unit, Dept. of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Glostrup, Glostrup, Denmark, 2Department of Radiology, Rigshospitalet, Glostrup, Glostrup, Denmark |
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Our research unit became in the end of 2018, involved in a major research project, where we over a period of 3 years shall MRI scan a cohort of 600, 10-year-old children. The MR scanning’s results, will be a part of a larger project, where the children have been followed with different test since birth. For the project, it will be very important that we get high image quality. Scanning children without sedation can be a bit of a challenge. We shortened our research protocol as much as possible and found a cheap solution to entertain children during the scan. |
| S7
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FA Value After 1 Week Decompressive Surgery is a Prognostic Factor in Patients with CSM | |
| Takumi Yokohama1, Motoyuki Iwasaki2, Daisuke Oura1, Sho Furuya3, Yoshimasa Niiya2, and Tomoyuki Okuaki4 | ||
1Radiology, Otaru General Hospital, Otaru, Hokkaido, Japan, 2Neurosurgery, Otaru General Hospital, Otaru, Hokkaido, Japan, 3Nuclear of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan, 4Radiology, Philips Healthcare, Tokyo, Japan |
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We evaluated the perioperative FA change in CSM patients using ZOOM DTI. As a result, the FA value after decompression surgery showed the proper state of the damaged cord and had a significant positive relationship with the patient’s outcome. The postsurgical FA value can become an accurate prognostic factor. Besides, the presurgical FA value did not have any relationships with the patient’s outcome, the reason why that a masking effect as an “Aligned Fibers Effect” due to strongly stenosis even using fine resolution DTI. |
| S12
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Advances in Neonatal Brain MRI: 1.5T to 3T | |
| Peik Yen Teh1, Weiling Lee1, Kim Hin Lo1, and Sarat Kumar Sanamandra1 | ||
1Singapore General Hospital, Singapore, Singapore |
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Advances of neonatal brain imaging from 1.5T to 3T is beneficial as the additional signal gained from a greater magnetic field strength can be translated into higher spatial resolution and shorter acquisition time. This improves the depiction of intracranial structures and abnormality, hence better clinical outcome can be achieved. Nevertheless, the pitfalls with greater magnetic field strength need to be addressed to reap the benefit of higher magnetic field strength. |
| S21 | Texture analysis of DCE-MRI for glioma grading | |
| zhao pengfei1, gao yang2, and qiao pengfei2 | ||
1Department of MRI, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China, 2Department of MRI, Affiliated Hospital of Inner Mongolia Medical University, Huhhot, China |
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The present study investigated the application of texture analysis of DCE-MRI in different ROIs in glioma grading. 50 with HGG (WHO grade III–IV) and 50 with LGG (WHO grade I–II) were included. All tumors were confirmed by pathology, and patients underwent DCE-MRI. The quantitative parameter of inhomogeneity was determined for two ROIs: whole tumor and solid portion. For both whole tumor ROI, heterogeneity was significantly different between HGG and LGG (P = 0.01). For the solid portion ROI, inhomogeneity was not significantly different between HGG and LGG (P = 0.07). Whole tumor inhomogeneity demonstrated higher diagnostic accuracy. |
| S16 | Benefits of Spiral MRI in routine brain imaging of pediatric patients with a VNS: prelim results | |
| Amber Pokorney1, Jeffrey Miller1, and Ryan Robison1 | ||
1Phoenix Children's Hospital, Phoenix, AZ, United States |
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To compare the image quality and diagnostic utility of a spiral 3D inversion recovery gradient echo sequence versus a conventional 3D inversion recovery gradient echo sequence (i.e.TFE). |
| S36 | Intra-individual open-label, single center study to compare unenhanced MRI with Dotarem enhanced MRI in pediatric and neonatal patient population (<18years) | |
| Amber Pokorney1, Jeffrey Miller1, and Ryan Robison1 | ||
1Phoenix Children's Hospital, Phoenix, AZ, United States |
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The primary objective to this study was to demonstrate superiority of lesion visualization of Dotarem enhanced MRI over unenhanced MRI along with the evaluation of safety and efficacy of Dotarem enhanced MRI in pediatric and neonate patients. Safety variables as well as the assessment of adverse events (AEs) for Dotarem enhanced MRI were collected. |
| S31
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Performance of Automatic B0 Shim Modes for Brain MR Spectroscopy on 7T and 3T | |
| Huijun Vicky Liao1, Eduardo Jorge Uribe Coello1, and Alexander P. Lin1 | ||
1Radiology, Brigham and Women's Hospital, Boston, MA, United States |
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For magnetic resonance spectroscopy, automated B0 shim mode may save scan time in a fast-paced clinical environment but is strongly dependent on performance. Two shim modes were compared in multiple brain regions at Siemens 3T and 7T. B0 maps were used to evaluate the shimming performance of each mode in the left hippocampus region. The results show that advanced shim mode is preferred on 7T (syngo MR VE12) and brain shim mode is preferred on 3T (syngo MR VE11) for brain MRS. However, more sophisticated shimming methods are still suggested for scanning more inhomogeneous regions if time permits. |
| S32 | Useful sequence for suppressing the radiofrequency shielding effect of a titanium mesh | |
| Yasuo Takatsu1,2, Rei Yoshida3, Kenichiro Yamamura4, Yuya Yamatani5, and Tosiaki Miyati2 | ||
1Tokushima Bunri University, Sanuki, Japan, 2Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan, 3Kurihara Central Hospital, Kurihara, Japan, 4Osaka Medical College Hospital, Takatsuki, Japan, 5Nara Medical University Hospital, Kashihara, Japan |
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To determine which sequence for routine contrast-enhanced brain MRI (2-dimentional spin echo, 2D SE; and 3-dimentional gradient echo, 3D GRE) exhibits less RF shielding effect of the titanium mesh after cranioplasty, using a phantom in multi vendor. Every vendor had similar signal attenuation ratio and normalized absolute average deviation (NAAD) in the proximal section of phantom image. With regard to NAAD, there was a significant difference between 2D SE and 3D GRE (P < 0.05). 3D GRE shows less RF shielding effect of a titanium mesh, and it might be appropriate sequence for MRI when a titanium mesh is present. |
| S33 | Effectiveness of distortion correction for diffusion-weighted imaging using clinical images | |
| Yasuo Takatsu1,2, Hajime Sagawa3, Masafumi Nakamura4, Yuichi Suzuki5, and Tosiaki Miyati2 | ||
1Tokushima Bunri University, Sanuki, Japan, 2Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan, 3Kyoto University Hospital, Kyoto, Japan, 4Otsu City Hospital, Otsu, Japan, 5The University of Tokyo Hospital, Bunkyo-ku, Japan |
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We investigated whether our distortion correction method could be applied practically for clinical breast MRI. The cross-correlation coefficients (CCCs) of the whole image and high-intensity regions (HIR) were calculated to assess the correlations between b0 and FS-T2WI images and b1500 and T1CE images. For all these combinations of images, the CCCs showed higher correlations with distortion correction than without the correction. This method could be adapted to any type of breast and HIR. Our method is particularly helpful as there is no additional scan and no extension in the scan time. |
| S37 | 3D T2-FFE sequence—a novel 3D isotropic MR neurography technique used in the lumbosacral plexus: technical advantages over PROSET sequence | |
| Jinglian Zhong1 and Bingjia Lai1 | ||
1Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China |
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3D T2-FFE sequence based neurography sequence yields images with high resolution, excellent background suppression and that enables detailed imaging of the nerves with excellent quality.Both 3D T2FFE and PROSET sequences can display the morphology of the lumbosacral plexus. However, compared with PROSET sequences, 3D T2FFE has good T2 effect, good background suppression and higher contrast. 3D T2FFE sequence can visually and clearly show the lumbosacral plexus, which has good clinical application value and is worth promoting. |
| S40 | The value of magnetic resonance diffusion imaging (MRI) combined with DTT in disease evaluation of senile cerebral infarction patients was analyzed | |
| wang chen1 | ||
1MRI, HuaDong Hospital, Shanghai, China |
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The value of magnetic resonance diffusion imaging (mri) combined with DTT in disease evaluation of senile cerebral infarction patients was analyzed . To observe and analyze the value of mris combined with DTT in disease evaluation of senile cerebral infarction patients. Compared with the NIHSS score predicts patients disease assessment, through magnetic resonance diffusion imaging and DTT technology evaluation in patients with disease, the accuracy is higher, so the magnetic resonance diffusion imaging joint DTT disease in elderly patients with cerebral infarction assessment has more clinical value. |
| S41 | The Value of IVIM in the Diagnosis of Pancreatic Carcinoma | |
| Liu ze qun1 and Sun wen ge1 | ||
1The First Affiliated Hospital of China Medical University, Shen yang, China |
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To evaluate the clinical application value of the monoexponential model of diffusion-weighted imaging(DWI), biexponential and stretched-exponential models of intravoxel incoherent motion(IVIM) in the diagnosis of pancreatic cancer.Retrospective collect and analyse 30 pancreatic carcinomas proven bu histopathology and/or clinical history.At the same time, 25 cases of normal pancreas were examined. In this study, multiple IVIM parameters have significant difference on the PC diagnosis from NP, and the diagnostic efficiency better than ADC value of DWI; the alpha value from IVIM sequence of the stretched exponential model is the best parameters in differential diagnosis of pancreatic carcinoma from normal tissue. |
| S42 | Evaluation gastrocnemius muscle in osteoarthritis of knee using T2 mapping | |
| Yi Cao1, Yeda Wan2, and Binamra Gurung2 | ||
1Radiology, Tianjin hospital, Tian Jin, China, 2Radiology, Tian jin hospital, Tian jin, China |
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Osteoarthritis is a common chronic disease affecting the joints in older population. Knee pain or stiffness along with other specific knee joint symptoms are common entities found in future sufferers of osteoarthritis. Weight bearing joints such as the knees and hips are heavily affected. T2 mapping is a quantitative MRI technique that enables the quantification of inflammatory changes. However, most existing T2 mapping techniques are also sensitive to changes in the fat content. To evaluate lateral and medial gastrocnemius muscle in asymptomatic symptomatic individuals and patients with symptoms scheduled for knee replacement using T2 mapping. |
| S43 | Assessing the reproducibility of semi-automated segmentation methods on post-operative T1 post contrast and FLAIR MRI images of GBM | |
| Olga Fadeeva Da Costa1,2,3, Shah Islam1,3, Melanie Morrison3, Fahdi Kanavati3, Eric Aboagye3, and Adam Waldman1,4 | ||
1Imaging, Imperial College Healthcare NHS Trust, London, United Kingdom, 2Imperial Health Charity, London, United Kingdom, 3Department of Surgery & Cancer, Cancer Imaging Centre, Imperial College London, London, United Kingdom, 4Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom |
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Glioblastomas (GBMs) are common adult primary brain tumours with high variable prognosis and a therapeutic response and outcome dominated by individual tumour biology. Magnetic resonance imaging (MRI) allows assessment of disease status following treatment. Accurate segmentation of GBM is the key for development of novel imaging biomarkers. A total of 35 MRI scans were analysed from patients withbiopsy confirmed GBM. Segmentation reproducibility between the two readers using semi automation was assessed and was found to be borderline. Future work is warranted using fully automated techniques to refine this ongoing work. |
| S44 | Multiband and Multi-echo EPI – the good, the bad and the future of fMRI at ultra-high field | |
| Rebecca Glarin1,2, Yasmin Blunck1, and Bradford Moffat1 | ||
1MBCIU, The University of Melbourne, Parkville, Australia, 2Royal Melbourne Hospital, Melbourne, Australia |
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Functional MRI is a dominant tool in both neuroscience research and neurosurgical planning. Multiband EPI can not be ignored as a staple acquisition tool for fMRI. It has the ability to assist in improving temporal resolution, spatial resolution and signal to noise. When using this highly effective and efficient technique there are considerations in order to gain the most for the sequence without producing detrimental imaging artefacts. Once the technique is understood there is a future application of Multiecho Multiband EPI which can potentially be used with great success to increase sensitivity and specificity of BOLD signal and fMRI. |
| S46 | APT-CEST for pH imaging; a phantom study using egg white powder | |
| Yoshihiro Akatsuka1, Hiroyuki Takashima1, Rui Imamura1, Hiroshi Nagahama1, and Mitsuhiro Nakanishi1 | ||
1Division of Radiology and Nuclear Medicine, Sapporo Medical University Hospital, Sapporo, Japan |
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We examined whether APT-CEST can reflect the difference of pH in solutions using egg white powder (EWP) using a 3-Tesla MRI. EWP was dissolved in distilled water to various concentrations, and their pH levels were subsequently titrated to 6.7-7.2. CEST effect (%)/ pH in 3.8 % solution were 3.27 ± 0.11/ 6.7, 3.46 ± 0.14/ 6.8 and 3.95 ± 0.11/ 7.2. CEST effect (%)/ pH in 4.7 % solution were 3.97 ± 0.17/ 6.8, 4.56 ± 0.15/ 6.9 and 4.88 ± 0.14/ 7.2. The solution using EWP can be used as a phantom reflecting the difference of pH in APT-CEST. |
| S50 | Plugging the gap: A reassessment of gadolinium administration policy in patients of unknown pregnancy status | |
| Dejian Qiu1, Bertwin Chen1, Peik Yen Teh1, and Tee Meng Tan1 | ||
1Radiological Sciences, Singapore General Hospital, Singapore, Singapore |
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The administration of gadolinium-based contrast agents in magnetic resonance imaging (MRI) is traditionally avoided during pregnancy, due to safety concerns over gadolinium exposure to the fetus. In our institution, female patients of reproductive age are required to undergo a urine pregnancy test (UPT), should contrast-enhanced MRI be required. However, this policy is not sufficiently comprehensive in safeguarding patients in the early stages of pregnancy as a UPT can be inaccurate between days 14 to 28 of the menstrual cycle. This presentation will reassess and propose changes to the gadolinium administration policy in patients of unknown pregnancy status in our institution. |
| S51
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Iron overload detection in extra-hepatic organs on a high-performance 0.55T scanner | |
| Christine Mancini1, W. Patricia Bandettini1, Peter Kellman1, Hui Xue1, Anna Conrey1, Swee Lay Thein1, and Adrienne E. Campbell-Washburn1 | ||
1Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States |
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Normal iron storage can be found in the liver. When the liver becomes saturated with iron due to a primary or secondary disease process, the iron will deposit in targeted extra-hepatic organs. T2*-based imaging is a non-invasive tool for quantifying iron in an individual organ. This study compared the T2* imaging of extra-hepatic organs on a 1.5T and a prototype low field 0.55T. These results were then compared to blood ferritin levels and found to have a modest correlation. |
| S52 | The upper limit of accelerating on three-dimensional (3D) -TSE using compressed sensing MRI (CS) | |
| Rui Imamura1, Hiroyuki Takashima1, Mitsuhiro Nakanishi1, Hiroshi Nagahama1, and Yoshihiro Akatsuka1 | ||
1Division of Radiology and Nuclear Medicine, Sapporo Medical University Hospital, Sapporo, Japan |
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The CS technique has been applied to various sequence of MRI, which helped reduce the acquisition time while showing minimal effect on image quality. The aim of this study was to investigate the change of image quality and resolution with increase of acceleration factor, and reveal the upper limit of the number of acceleration factor of CS with 3D MRI. The line profile slope was significantly different with acceleration factor higher than 22 compared to without PI. Our results suggested that the upper limit of acceleration factor on T2WI with 3D-TSE was 22 because of decrease of resolution. |
| S53 | Multiple Targets for Drug Infusion Using Real-Time Convection-Enhanced Delivery in NHP Model for Therapies of Neurodegenerative Disorders | |
| Anna M Borkon1, Michael J DiBalsi2, Megan Keiser3, and Timothy H Lucas4 | ||
1Research, University of Pennsylvania, Philadelphia, PA, United States, 2ClearPoint, ClearPoint, MRI Interventions, INC., Irvine, CA, United States, 3The Center for Cellular and Molecular Therapy, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States, 4Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States |
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The current technological advances of the intracranial Convection-Enhanced Delivery (CED) open a novel possibility for infusing therapeutics directly into multiple targets located in the same cerebellar hemisphere with high precision and safety. The presented experiment is based on the AAV1 infusion into the Deep Cerebellar Nuclei (DCN), namely the dentate, interposed and fastigial in NHPs using the real-time CED approach. In retrospect, the conclusion of this experiment is that multiple targets located close to each other in the brain can be successfully infused during the same MRI session with no or minimal reflux visualized on the post-infusion images. |
| S55 | Tiny Bubbles versus Spinning Protons: Can Contrast-Enhanced Transfontanelle Ultrasound (ce-TUS) Compete with MRI in Neonatal Brain Imaging? | |
| Nancy Hill Beluk1, Morie Kephart2, Ashok Panigrahy1, and Judy H. Squires1 | ||
1Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 2Aureus Medical Group, Omaha, NE, United States |
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MRI is considered to be the current gold standard for neonatal brain imaging. However, there are often challenges when transporting critically ill neonates for diagnostic imaging studies including clinical instability, safety related to patient transport, the possible need for sedation, and MR incompatibility of patient monitoring equipment. Our study retrospectively examined standard brain MRI to contrast-enhanced transfontanelle ultrasound (ce-TUS) in neonates. |
| S76 | What Information Can Diffusion Tensor Fractional Anisotropy Provide Relative to Environmental Enrichment in Children with Congenital Heart Defects? | |
| Nancy Hill Beluk1, Tracy Baust2, Vincent Kyu Lee1, Benjamin Meyers1, Julia Wallace1, Lauren Lorenzi3, Alexandra Mikulis2, Maddie Chrisman4, Yulia Domnina2, and Ashok Panigrahy1 | ||
1Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States, 2Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, United States, 3Behavioral Health Sciences, University of Pittsburgh Medical Center, Pittsburgh, PA, United States, 4Physical and Occupational Therapies, University of Pittsburgh Medical Center, Pittsburgh, PA, United States |
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Children with Congenital Heart Defects (CHD) are at an increased risk for neurological deficits and neurodevelopmental delays with the most common anomaly being white matter injury (WMI). Diffusion tensor imaging (DTI), uses water’s diffusivity to characterize microstructural changes in WM. One DTI metric, fractional anisotropy (FA), increases with myelination and decreases in the presence of demyelination. We examined the association between early developmental therapies (such as OT, PT, and SLP) and WMI in infants with CHD using FA as a quantitative imaging metric for white matter integrity. |
| S57 | Impact of Reformatting Brain PET Images to the AC-PC line of MR images | |
| Vahid Ravanfar1, Mohammad Mehdi Khalighi2, Chad Bobb3, Namasvi Jariwala1, Edgar Castellanos Diaz1, Emma Bahroos1, and Javier Villanueva-Meyer1 | ||
1Radiology, UCSF, San Francisco, CA, United States, 2Stanford University, Palo Alto, CA, United States, 3PET/MR Engineering, GE Healthcare, Waukesha, WI, United States |
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When PET images are fused to MR images which are aligned to the Talairach anterior commissure (AC) – posterior commissure(PC) line, the PET images are reformatted to the AC-PC plane. The reformatting of the PET images may change the visual appearance of a tumor based on the axial slice angle of the fused images. When reading PET/MR images, one must note the displayed plane of PET images as compared to the MR images. Cross-referencing between PET and MR should be performed on images displayed in the same plane. |
| S58 | Application of super-fast and high resolution magnetic resonance imaging with pathology in the diagnosis of fetal central nervous system abnormalities | |
| LI MING1 | ||
1radiology departmengt, NANJING DRUM TOWER HOSPITAL, NANJING, China |
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To investigate the role of super-fast and high-resolution MRI in vivo and in vitro fetus confirmed by pathological autopsy. The fetuses were scanned with 1.5T, Philips, Balance-Fast Field Echo(B-FFE) and half-fourier acquisition singo-shot T2W-DRIVE， in vivo. Ten of them took MRI scans in vitro within 2 hours after induced labor then autopsy. The post-mortem MRI sequences were susceptibility weighted imaging(SWI)。Two fetus were confirmed abnormalities in brain and 8 were body malformation after autopsy. The findings of ultrasound, prenatal and post-mortem MRI were contrasted with autopsy as a retrospective study. |
| S59 | What is the appropriate number of acceleration factor of compressed sensing with diffusion weighted image? | |
| Hiroyuki Takashima1, Mitsuhiro Nakanishi1, Hiroshi Nagahama1, Rui Imamura1, and Yoshihiro Akatsuka1 | ||
1Division of Radiology and Nuclear Medicine, Sapporo Medical University Hospital, Sapporo, Japan |
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In several recent studies, the compressed sensing (CS) technique has been applied to various sequence, which helped reduce the scan time while showing minimal effect on image quality. However, the appropriate number of acceleration factor of CS is unclear. We aimed to reveal the appropriate number of acceleration factor of CS with TSE-DWI. We calculated %CV from the image of ADC, the similarity between images of the control and the accelerated sequences was evaluated using structural similarity index (SSIM). From results of this research, the appropriate number of acceleration factor of CS with TSE-DWI was revealed as up to 4. |
| S60 | Usability Comparison of a Portable Low-Field, Point-of-Care MRI Scanner with High-Field MRI | |
| Lisa M Desiderio1, Danielle Urban1, Lauren Karpf1, Leeanne Lezotte1, Sabrina Williams1, Samantha By2, Brian Welch2, Jacqui Meeks1, Bridget Pomponio1, Andrea Pogozelski1, and Joel M Stein1 | ||
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Hyperfine Research Inc, Guiford, CT, United States |
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The purpose of this study is to evaluate the usability and acceptability of a newly developed low-field (64 mT), portable, point-of-care (POC) MRI scanner in comparison to standard clinical high-field (1.5 and 3T) imaging from both a patient and operator perspective. Standard MRI units are expensive and technically challenging to install, maintain, and operate and can be difficult for some patients with sensitivity to noise or claustrophobia. Based on our early experience, we find that the experience of POC MRI can be acceptable and preferable to patients as well as operators, including personnel without a technical background in MRI. |
| S62 | Is B1+rms as reliable as we think? A quantitative review. | |
| Jennifer Croll1 and Gemma Stoddart1 | ||
1Royal Melbourne Hospital, Melbourne, Australia |
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Specific Absorption Rate (SAR) and B1+rms are two radiofrequency (RF) exposure metrics used in MRI. The monitoring of RF exposure in patients with implants is crucial for ensuring compliance with specific implant scanning conditions. As SAR can be highly variable many implants now state a B1+rms value to allow scanning of conditional implants. However, more recently several scanner manufacturers have stated that the actual B1+rms value recorded during scanning may be higher than the predicted value. This could impact the scanning of patients with conditional implants and potentially compromise patient safety. |
| S65 | High spatial and temporal resolution dynamic contrast enhanced MRI of the breast for improved breast cancer detection: Differential Subsampling with Cartesian Ordering (DISCO) Versus LAVA VIBRANT-Flex Breast MRI | |
| Larowin Toni1, Olga Smelianskaia1, Sunitha Thakur1, and Katja Pinker-Domenig1 | ||
1Memorial Sloan Kettering Cancer Center, New York, NY, United States |
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MRI of the breast is the most sensitive test for breast lesion detection. The backbone of any breast MRI protocol is a high-resolution T1-weighted contrast enhanced sequence, which allows the assessment of high-resolution breast tumor and enhancement kinetics to depict angiogenesis as a tumor-specific feature. DISCO and LAVA VIBRANT-Flex MRI provide similar excellent image quality while allowing faster acquisition time and high spatial and temporal resolution. In comparison DISCO provides excellent fat suppression at 3T where conventional fat saturation techniques are often suboptimal, reduces motion artifacts and it provides better and higher spatial resolution. |
| S75 | Does computer-aided localization of a breast lesion impact Breast MRI-guided biopsies compared with manual localization? | |
| Larowin Toni1, Olga Smelianskaia 1, Elizabeth Morris1, and Yolanda Bryce1 | ||
1Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States |
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An MRI-guided breast biopsy can be lengthy and uncomfortable for the patient, which potentially can be mitigated by computer-aided software that helps localize the lesion, compared with manual localization. We performed a retrospective trial to see if a computer-aided software system reduces procedure length, increases accuracy, and increases confidence of the clinician performing the procedure. Our study demonstrates that computer-aided software can significantly decrease length of time of the procedure but does not impact accuracy of the biopsy or confidence of the clinician performing the procedure. |
| S111 | Accuracy of Non-Contrast MRI Biopsy in Diagnosing a Breast Cancer Pathologic Complete Response Following Neoadjuvant Chemotherapy | |
| Larowin Toni1, Olga Smelianskaia1, Elizabeth Morris1, and Elizabeth Sutton1 | ||
1Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States |
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Non-contrast MRI-guided biopsy is a promising minimally-invasive approach with high accuracy in diagnosing a breast cancer pathologic complete response post-neoadjuvant chemotherapy which could potentially obviate surgery in this subset of patients. |
| S71
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Optimization of Metal Artifact Reduction (O-MAR) Imaging | |
| Dave Hitt1, Jonathan Chia1, Robert Lay1, Tom Lowe1, Michael Pawlak1, John Penatzer1, James Snicer1, Marcie Stopchinski1, Gregory Thomas1, Paul Worthington1, Kristen Williams1, and Brian Johnson2 | ||
1Philips Healthcare, Gainesville, FL, United States, 23545 SW 47th Ave, Philips Healthcare, Gainesville, FL, United States |
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Patients with MR Conditional orthopedic implants can be challenging to scan due to susceptibility artifact from metal implants. Use of metal artifact reduction (MARS) techniques can help reduce signal loss from metal implants, however, are not usually sufficient to allow for detailed peri-prosthetic tissue visualization. Metal-induced field inhomogeneities cannot be accurately modeled, which is why O-MAR (MARS+VAT) can improve in-plane distortions by utilizing a more robust spatial encoding approach. Here we present the conceptual background behind the O-MAR technique and work done to provide guidance for optimized metal reduction imaging protocols. |
| S74
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Respiratory Pacing – A Low-Tech Solution to a Universal Struggle? | |
| Ortman Jason1, Jennifer Wagner2, Bharath Ambale1, Yoko Kato3, Jaclyn Sesso3, Yoshimori Kassai4, Larry Kasuboski2, and Joao Lima3 | ||
1Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Canon Medical Research Unit, Mayfield VIllage, OH, United States, 3Cardiology, Johns Hopkins University, Baltimore, MD, United States, 4Canon Medical Systems, Otawara-Shi, Tochigi, Japan |
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For respiratory triggered and gated acquisitions, variance in the natural respiratory cycle often complicates workflow, extending scan times and reducing image quality. This abstract discusses the hypothesis that by providing continuous auditory guidance, or "respiratory pacing", the efficacy of respiratory triggered and gated sequences may be improved. The importance of mimicking natural respiratory patterns was quickly noted, as were key differences in the success of respiratory pacing when applied to different acquisitions. Other interesting observations included an observable increase in diaphragmatic travel when respiratory pacing was applied and the extension of scan lengths due to diaphragmatic fatigue over time. |
| S77 | GRAPPA vs SMS Fast Brain MRI Compared to ACR Specifications | |
| Mark J Burton1, Robert Thomen1, Talissa A. Altes1, Carlos Leiva Salinas1, Nicholas Tustison2, and Joseph P Cousins1 | ||
1Radiology, University of Missouri Hospital, Columbia, MO, United States, 2Radiology, University of Virginia, Charlottesville, VA, United States |
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This work was to assess the trade-off between scan time and image quality afforded by acceleration techniques GRAPPA and simultaneous multi-slice (SMS). We imaged an ACR phantom using standard clinical T1, T2, and FLAIR sequences. Then, without altering any other scan parameters, we increased GRAPPA and SMS acceleration factors (2, 4, and 6). All GRAPPA and SMS accelerated scans passed the ACR resolution criteria. Both GRAPPA and SMS passed low-contrast criteria at acceleration factor 2, but factors of 4 and 6 did not. GRAPPA and SMS gave nearly identical similarity indices and SNR at all acceleration factors. |
| S78 | Evaluation of an ultra-fast 4D MRI sequence for the diagnosis of breast lesions | |
| Belinda Lokaj1, Karen Kinkel2, Jean-Noel Hyacinthe3, Jérôme Schmid3, and Céline Gaignot3 | ||
1Master of Science in Health Sciences, HES-SO /UNIL, Lausanne, Switzerland, Lausanne, Switzerland, 2Institut de radiologie, Clinique des Grangettes, Chêne-Bougeries, Geneva, Switzerland, Geneva, Switzerland, 3Geneva School of Health Sciences, HES-SO // University of Applied Sciences and Arts of Western Switzerland, Geneva, Switzerland |
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Breast MRI is promoted as a tool for breast cancer screening because of its high sensitivity. Possibility of differentiating between benign and malign lesions has been studied using lesion enhancement parameters on DCE, thus helping to reduce examination time. This study was designed to verify sensitivity and specificity for lesion characterization. Time to Enhancement and Maximum Slope of the enhancement curve obtained from an ultrafast sequence were evaluated. Preliminary results tend to confirm that performing breast lesions screening using ultrafast-DCE is a valuable alternative to the standard MRI Breast protocol, possibly opening diagnostic perspectives to a wider population of women. |
| S86 | Fat Fraction may be used as a radiographic evaluation index for vertebral bone metastasis：a report of 4 cases | |
| Hui Hao1, Jia Yin Tong1, Xiao Cheng Wei2, Jian Xin Guo1, and Jian Yang1 | ||
1Department of Radiology, The first affiliated hospital of xi 'an jiaotong university, Xi'an, China, 2MR Research China, GE Healthcare, BeiJing, China |
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Bone metastasis is a common complication of advanced malignant tumors with severe simptoms. Common imaging modalities for bone metastasis diagnosis include X-ray, CT,MRI, SPECT, and PET. PET is the golden standard, but the nature of radiation, metabolic risk and high price have limited PET from widely clinical use. In this work, we presented 4 cases of bone metastasis which had had a difference in MRI derived fat fraction between bone metastatic vertebrae and normal non-metastatic vertebrae. MR results were also coincided with PET results. MRI derived fat fraction may be used as an imaging evaluation index for bone metastasis. |
| S87 | Analysis on breast tumor movement using MRIs scanned in prone and supine positions | |
| chuan bing wang1 and da peng li2 | ||
1Department of Radiology, the First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing, China, 2the First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), nan jing, China |
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The aim of this study is to evaluate the volume change of breast tumor, various kinds ofspatial movementin nipple and the bottom center of the sternum origin, and distance from tumor center to the chest wall from prone to supine MRIs, and then to predict more accuracy tumor positions for surgical planning in the operation room. |
| S91 | Lower risk of hearing loss without sacrificing image quality in fetal MR imaging: a feasibility study using acoustic reduction technique | |
| Le Cao1, Xiang Liu1,2, and Jianxin Guo1 | ||
1The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi,, China, 2The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China |
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3.0T MR scanner can achieve superior image quality depicting fetal anatomic details over 1.5T, but may poses higher risk of adverse impact on fetal auditory development due to its intrinsically higher acoustic noise level. This comparative study investigated the value of acoustic noise reduction technique in fetal exam. The result shows the technique can acquire equivalent quality images in 3.0T scanner, meanwhile decrease hearing loss risk in fetal head examinations compared with the conventional method. |
| S97 | A technical approach to reduce inhomogeneities and image distortion in PET/MRI imaging using mMR Breast coil | |
| Pradeep Singh Negi1,2,3, Shashi Bhushan Mehta1,2, Amarnath Jena1,2, and Sangeeta Bhushan Taneja1 | ||
1Molecular Imaging & Nuclear Medicine, Indraprastha Apollo Hospitals, New Delhi, India, 2Physics, Vivekananda Global University, Jaipur, India, 3PET SUITE, House of Diagnostics, New Delhi, India |
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Inhomogeneity in fat suppression and image distortion pose problem in Breast MRI specially in the diffusion and dynamic fat suppressed images using mMR breast coil. The purpose of this work to improve fat-superstation and minimize image distortion in the breast imaging before applying the MRI sequence specially in Dynamic fat-supressed Contrast and Diffusion images. 330 breast cancer patients have been taken for this study. Volume shim was applied in all patients and water peak shift corrected manually when required. Our results show reduction in image distortion in diffusion and improving in fat-supressed MRI images. |
| S98
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Fetal Cardiac Imaging Utilizing Retrospectively Gated 2D Radial MRI | |
| Kristina Mary Pelkola1, Onur Afacan1, Tess E. Wallace2, Jason A. Ferro1, Carol M. Backman1, Davide Piccini3,4,5, Tobias Kober3,4,6, Carol E. Barnewolt1, Susan A. Connolly1, Judy A. Estroff2, and Simon K. Warfield1 | ||
1Radiology, Boston Children's Hospital, Boston, MA, United States, 2Boston Children's Hospital, Boston, MA, United States, 3Advanced Clinical Imaging Technology, Siemens Healthcare, Lausanne, Switzerland, 4Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 5LTS5, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland, 6LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland |
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Fetal MRI is a rapidly growing field that facilitates diagnosis and treatment providing improved maternal and fetal care. New imaging strategies are needed to improve the assessment of cardiac structure and function. We assessed an interactive fetal cardiac prototype sequence enabling the fetal heart to be imaged in real-time, while prescribing the imaging plane to fetal movement. Once positioned to the long axis, a sequence of 2D radial readouts are acquired, enabling inline reconstruction of beating heart images with a frame rate between 0.5s and 1s. This new capability allowed assessment the anatomy and function of the fetal heart. |
| S99 | Operating a Hybrid PET/MR Scanner: Challenges and Opportunities | |
| Dawn Holley1, Kim Halbert1, and Mehdi Khalighi1 | ||
1Radiology, Stanford University, Stanford, CA, United States |
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Simultaneous PET/MR imaging is still a relatively new dual modality. As such, unique challenges are commonly faced across departments. What were once commonly separate, Nuclear Medicine and Radiology departments now need to work together to create new workflows, protocols and management systems. Questions commonly arise regarding how these two modalities and departments can best come together for management success. A survey of 19 questions was distributed to 12 different PET/MR departments in order to gain an understanding of what challenges are often faced and how to resolve them, as well as any commonalities across successful departments. |
| S101 | A comparison of 2D High resolution PROPELLER with 3D Fast spin echo imaging on multi-planar reconstruction | |
| Ho Beom Lee1 and Kwan Woo Choi2 | ||
1Asan Medical Center, Seoul, Republic of Korea, 2Wonkwang Health Science University, Iksan, Republic of Korea |
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2D High resolution PROPELLER technique was compared to 3D Fast spin echo imaging on axial and reformatted (sag and cor) images. |
| S109 | 7T Knee MRI: Clinical Benefits and Challenges | |
| Kevin Epperson1, Karla Epperson1, Garry Gold1, and Feliks Kogan1 | ||
1Radiology, Stanford University School of Medicine, Stanford, CA, United States |
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Diagnostic MRI scanning of the knee at 3T offers multiple contrasts and definition of anatomical structures, presenting pathology, and allows quantitative performance methods. Ultra high field (7T) systems offer improved resolution and SNR for visualization of small morphological changes and translation of quantitative methods presents challenges in field uniformity and shading artifacts which limit the robustness and clinical potential of these systems.In this work we implement a new method to overcome field inhomogeneity errors and assess the potential clinical benefits of knee imaging at 7T. |
| S115 | Building an MRI RF Coil for the Technologist | |
| Rene Jack Roy1 | ||
1UVA, charlottesville, VA, United States |
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The complexity and costs of MRI RF coil design seems out of reach for most non-physicists in the medical research field. To facilitate learning more about coil design and functionality, we have attempted to build a simple loop coil that can be used in small animal research. |
| S116 | An exploration of MRI patient safety decision making processes using ‘social media’ as a data resource | |
| Renee Mineo1, Claire Mulcahy1, Shawna Farquharson1, and Alan Connely2,3 | ||
1MRI, The Florey Institute of Neuroscience and Mental Health, Heidelberg, Australia, 2Imaging, The Florey Institute of Neuroscience and Mental Health, Heidelberg, Australia, 3Imaging, The Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia, Melbourne, Australia |
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This study reviewed the engagement of MR Radiographers & Technologists with a social media platform seeking professional guidance with MR safety decision making processes regarding implants or devices. From June 2016 to August 2018 100 discussion items were reviewed and categorized. Our study identified that the ‘consensus to scan or not to scan’, was not completely dependent on the presence of detailed information about the implant or device. |