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Application of a novel 13C hyperpolarized metabolic tracer for ?-Glutamyl transferase activity in vivo tumor xenograft

Author:Tomohiro Seki  Marino Itoda  Shun Kishimoto  Kazu Yamamoto  Yoichi Takakusagi  Jeffery Brender  Ronja Malinowski  Tatsuya Nishihara  Hikari Yoshihara  Hiroshi Nonaka  Keita Saito  Nobu Oshima  Jan Ardenkjaer-Larsen  James Mitchell  Murali Krishna   Sando  

Author Institution:DTU  EPFL  NIH  QST  UT  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3052  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

Assessing ?-glutamyl transpeptidase activity in kidney using hyperpolarized ?-Glu-[1-13C]Gly

Author:Steffen Frank  Hikari Yoshihara  Marino Itoda  Shinsuke Sando  Rolf Gruetter  

Author Institution:EPFL  The University of Tokyo  University of Geneva  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3066  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

Boosting SABRE-SHEATH hyperpolarization with Coherent Control of Spin Dynamics

Author:Thomas Theis  Shannon Eriksson  Johannes Colell  Zijian Zhou  Jacob Lindale  Warren Warren  

Author Institution:Duke University  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3064  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

Comparison of Asymmetric and Symmetric K-space Sampling in EPI for 3D Time-Resolved Hyperpolarized 13C MRI with [1-13C]Pyruvate

Author:Benjamin Geraghty  Casey Lee  Albert Chen  Charles Cunningham  

Author Institution:GE Healthcare  Sunnybrook Research Institute  University of Toronto  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3071  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

Dynamic Hyperpolarized 13C MRSI using the SPICE technique: A feasibility study

Dynamic Metabolic Imaging of Co-Polarized [2-13C]Pyruvate and [1,4-13C2]Fumarate Using 3D-Spiral CSI with Alternate Spectral Band Excitation

Author:Maninder Singh  Sonal Josan  Dirk Mayer  

Author Institution:Siemens Healthcare  University of Maryland  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3054  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

Ex-vivo real-time measurement of ethanol induced changes in brain metabolism of hyperpolarized [1-13C]-pyruvate

Author:Benjamin Grieb  Assad Azar  Talia Harris  Gal Sapir  Atara Nardi-Schreiber  Ayelet Gamliel  Sivaranjan Uppala  Jacob Sosna  J. Gomori  Rachel Katz-Brull  

Author Institution:Hadassah-Hebrew University Medical Center  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3056  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

Hyperpolarized 13C chemical shift imaging of transient focal ischemia reperfusion injury in developing rat brain

Author:Shu-Juan Fan  Amara Larpthaveesarp  Yiran Chen  Sukumar Subramaniam  Robert Bok  Fernando Gonzalez  Duan Xu  

Author Institution:University of California San Francisco  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3072  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

HyperSIFT: Temoporal Denoising of Hyperpolarized Data Improves SNR while Perserving Dynamic Information

Author:Kristin Granlund  Kayvan Keshari  

Author Institution:Memorial Sloan Kettering Cancer Center  Weill Cornell Medical College  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3074  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

Impurities of [1-¹³C]pyruvic acid and their potential effects on the interpretation of hyperpolarized pyruvate metabolism studies

Author:Talia Harris  Ayelet Gamliel  Jacob Sosna  J. Moshe Gomori  Rachel Katz-Brull  

Author Institution:Hadassah-Hebrew University Medical Center  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3057  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

In vivo hyperpolarization transfer in a clinical MRI scanner

Author:Cornelius von Morze  Galen Reed  Peder Larson  Daniele Mammoli  Albert Chen  James Tropp  Mark van Criekinge  Michael Ohliger  John Kurhanewicz  Daniel Vigneron  Matthew Merritt  

Author Institution:Berkshire Magnetics  GE Healthcare  UCSF  University of Florida, Gainesville  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3059  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

In Vivo Spectroscopic Detection of Arginase Enzyme Activity with Hyperpolarized [6-13C,15N3]-Arginine

Author:Andrew Cho  Roozbeh Eskandari  Kayvan Keshari  

Author Institution:Memorial Sloan Kettering Cancer Center  Weill Cornell Graduate School  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3062  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

Monitoring effect of rapamycin on pyruvate metabolism in SCC tumor using hyperpolarized 13C-MRI

Author:Keita Saito  Shingo Matsumoto  Yoichi Takakusagi  Masayuki Matsuo  Hellmut Merkle  James Mitchell  Murali Krishna  

Author Institution:National Cancer Institute  National Institute of Neurological Disorder and Stroke  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3069  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

Multiscale Imaging of Breast Cancer Metabolism using Fluorescence Lifetime Imaging Microscopy and Hyperpolarized Magnetic Resonance Spectroscopy

Author:Sarah Erickson-Bhatt  Ben Cox  Erin Adamson  Suzanne Ponik  Matthew Conklin  Brett Morris  David Inman  Joseph Szulczewski  Patricia Keely  M. Elizabeth Meyerand  Caroline Alexander  Kevin Eliceiri  Sean Fain  

Author Institution:University of Wisconsin  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3070  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

Non-invasive redox molecular imaging of atopic dermatitis using in vivo dynamic nuclear polarization MRI

Author:Fuminori Hyodo  Hinako Eto  Gaku Tsuji  Masutaka Furue  Masayuki Matsuo  

Author Institution:Gifu University  Kyushu University  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3068  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

Novel Metabolic Markers for Therapeutic Approaches Targeting Serine Synthesis Pathway in Leukemia

Author:Sangmoo Jeong  Madeleine Gao  Alexandra Schurer  Nathaniel Kim  Yuanming Cheng  Roozbeh Eskandari  Michael Kharas  Kayvan Keshari  

Author Institution:Columbia University  Memorial Sloan Kettering Cancer Center  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3060  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

Quantitative Data Analysis of in vivo Hyperpolarized 13C NMR Data: 1D vs 2D

Author:Frits van Heijster  Ron de Beer  Arend Heerschap  Dirk van Ormondt  

Author Institution:Radboud University Medical Center  TU Delft  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3073  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

Real-time ex-vivo measurement of brain metabolism using hyperpolarized [1-¹³C]pyruvate

Author:Talia Harris  Assad Azar  Gal Sapir  Ayelet Gamliel  Atara Nardi-Schreiber  Jacob Sosna  J. Moshe Gomori  Rachel Katz-Brull  

Author Institution:Hadassah-Hebrew University Medical Center  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3058  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

Recent advances in low-cost, rapid Hyperpolarization Chemistry: from portable NMR to low-cost molecular MRI.

Super-resolution Hyperpolarized C13 Imaging with 2D-Linear Prediction and Trigonometric Curves

Author:Jack Miller  Sofia Dimoudi  Aaron Hess  Damian Tyler  

Author Institution:University of Oxford  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3065  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

Variable Resolution Echo-Planar Imaging for Improved Quantification of Hyperpolarized 13C Metabolism

Author:Jeremy Gordon  Eugene Milshteyn  Daniel Vigneron  Peder Larson  

Author Institution:UC San Francisco  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3053  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number: