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Application of a novel 13C hyperpolarized metabolic tracer for ?-Glutamyl transferase activity in vivo tumor xenograft

Author:Tomohiro Seki  Marino Itoda  Shun Kishimoto  Kazu Yamamoto  Yoichi Takakusagi  Jeffery Brender  Ronja Malinowski  Tatsuya Nishihara  Hikari Yoshihara  Hiroshi Nonaka  Keita Saito  Nobu Oshima  Jan Ardenkjaer-Larsen  James Mitchell  Murali Krishna   Sando  

Author Institution:DTU  EPFL  NIH  QST  UT  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3052  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

Developing a therapeutic strategy for a glycolytic cancer model by monitoring on-target in vivo efficacy of a newly developed LDH inhibitor using hyperpolarized 13C Magnetic Resonance Imaging

Monitoring effect of rapamycin on pyruvate metabolism in SCC tumor using hyperpolarized 13C-MRI

Author:Keita Saito  Shingo Matsumoto  Yoichi Takakusagi  Masayuki Matsuo  Hellmut Merkle  James Mitchell  Murali Krishna  

Author Institution:National Cancer Institute  National Institute of Neurological Disorder and Stroke  

Session Type:Traditional Poster  

Session Date:Thursday, 21 June 2018  

Session Time:13:15  

Session:Hyperpolarised MR  

Program Number:3069  

Presentation Time:

Room Number:Exhibition Hall 3052-3074  

Computer Number:

Multimodal Characterization of In Vivo Metabolic Activities with Hyperpolarized 13C MRI, 18F-FDG PET, and EPR Imaging in Pancreatic Ductal Adenocarcinoma Tumors

Author:Kazutoshi Yamamoto  Tomohiro Seki  Shun Kishimoto  Nallathamby Devasahayam  Nobu Oshima  Stephen Adler  Elaine Jagoda  Keita Saito  Jeffrey Brender  Peter Choyke  James Mitchell  Murali Krishna  

Author Institution:National Institutes of Health  

Session Type:Oral  

Session Date:Monday, 18 June 2018  

Session Time:16:15  

Session:Hyperpolarisation: Probe Development & Clinical Application  

Program Number:0279  

Presentation Time:17:39  

Room Number:S04  

Computer Number:

PET by MRI: Glucose Imaging by 13C MRS by Noise Suppression through Tensor Decomposition Rank Reduction

Author:Jeffrey Brender  Shun Kishimoto  Hellmut Merkle  Galen Reed  Ralph Hurd  Albert Chen  Jan Ardenkjaer-Larsen  Jeeva Munasinghe  Keita Saito  Tomohiro Seki  Nobu Oshima  Kazu Yamamoto  James Mitchell  Murali Krishna  

Author Institution:GE Healthcare  NIH/NCI  NIH/NINDS  Technical University of Denmark  

Session Type:Oral  

Session Date:Wednesday, 20 June 2018  

Session Time:16:15  

Session:Non-Proton MRS/MRI  

Program Number:0905  

Presentation Time:16:39  

Room Number:S02  

Computer Number: