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Hyperpolarized 13C MRSI monitoring of response to HDAC inhibition in glioblastoma

Author:Marina Radoul  Myriam Chaumeil  Pia Eriksson  Chloe Najac  Pavithra Viswanath  Mark Kelly  Anne Marie Gillespie  Joydeep Mukherjee  Russell Pieper  Sabrina Ronen  

Author Institution:University of California San Francisco  

Session Type:Oral  

Session Date:Wednesday, 20 June 2018  

Session Time:13:45  

Session:Imaging Response to Therapy  

Program Number:0809  

Presentation Time:14:57  

Room Number:S03  

Computer Number:

Hyperpolarized 13C ß-hydroxybutyrate/acetoacetate as a biomarker for non-invasive monitoring of NAD+/NADH status in glioblastoma

Author:Chloe Najac  Marina Radoul  Lydia Le Page  Georgios Batsios  Pavithra Viswanath  Anne Marie Gillespie  Sabrina Ronen  

Author Institution:University of California San Francisco  

Session Type:Combined Educational & Scientific Session  

Session Date:Wednesday, 20 June 2018  

Session Time:13:45  

Session:From Molecular Biomarker to Clinical Quantification  

Program Number:0780  

Presentation Time:15:15  

Room Number:S01  

Computer Number:

A Late-Stage Deuteration Method for T1 Prolongation and Enhanced In Vivo Signal to Noise Ratio of Hyperpolarized 13C Substrates