Synopsis

Keywords: Body: Liver, Contrast mechanisms: Fat

This talk will summarize the Draft QIBA PDFF Conformance Statement for liver MRI-PDFF which focuses on chemical-shift-encoded PDFF biomarker validation on conventional MRI scanners for clinical care. We will also use that document as a starting point to discuss validation of new MRI-PDFF techniques on conventional scanners, as well as novel new techniques such as low cost, portable, point-of-care MR-based liver PDFF assessment based on diffusion. We will also briefly discuss other opportunities to qualify and validate PDFF biomarkers, including in the context of drug development clinical trials, and in particular with regard to the FDA Biomarker Qualification Program (BQP).