Synopsis

Keywords: Body: Kidney

Motivation: Early identification of tissue fibrosis may be useful for the management of patients with renal disease but is difficult to achieve in vivo non-invasively.
Goal(s): We evaluated the ability of Magnetic resonance imaging (MRI) techniques to quantify renal fibrosis.
Results: MRI can assess renal fibrosis using through its impact on renal functional, structural, mechanical, and molecular attributes. Some available tools may not be specific to fibrosis alone and could be used in tandem with other indices of kidney damage and dysfunction.
Impact: Modulation of renal microstructure induced by renal fibrosis is detectable by MRI and could be clinically useful.

MRI of Kidney Fibrosis

Early identification of tissue fibrosis may be useful for the management of patients with renal disease but is difficult to achieve in vivo non-invasively. Magnetic resonance imaging (MRI) affords a range of approaches to probe renal fibrosis. MRI can assess renal fibrosis using through its impact on renal functional, structural, mechanical, and molecular attributes. Some of the available tools (e.g., DWI, BOLD) may not be specific to fibrosis alone and could be used in tandem with other indices of kidney damage and dysfunction. Therefore, Modulation of renal microstructure induced by renal fibrosis is detectable by MRI and could be clinically useful. Integration of different imaging approaches or multiparametric MRI may provide complementary information to confirm functionally significant kidney fibrosis.

Acknowledgements

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References

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