Synopsis

Keywords: Contrast mechanisms: Microstructure, Neuro: White matter, Neuro: Grey matter

This lecture will present the state-of-the art of brain microstructure mapping by biophysical modeling of diffusion MRI (dMRI). At long diffusion times, axons can be modeled as impermeable sticks, leading to the so-called standard model (SM) unifying popular WM models including NODDI, WMTI and SMT. We will discuss how to improve estimation of SM and free water fraction by acquiring complimentary information (high diffusion weighting, free gradient waveforms, varying echo-times). Next, we will also discuss how to measure microstructural features beyond the standard model in white matter (axon diameters and axonal beading) and gray matter (soma density and exchange).

for examples code and usage see
https://github.com/NYU-DiffusionMRI/DESIGNER-v2

Acknowledgements

No acknowledgement found.

References

Mapping tissue microstructure of brain white matter in vivo in health and disease using diffusion MRI. Ying Liao, Santiago Coelho, Jenny Chen, Benjamin Ades-Aron, Michelle Pang, Valentin Stepanov, Ricardo Osorio, Timothy Shepherd, Yvonne W. Lui, Dmitry S. Novikov, Els FieremansImaging Neuroscience (2024) 2: 1–17