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Association between Paravertebral Muscle Radiological Parameters Alterations and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study1the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, zhejiang, China
Synopsis
Keywords: Liver, Fat, non-alcoholic fatty liver disease; non-alcoholic steatohepatitis
Motivation: This study aims to assess the alterations in skeletal muscle parameters in patients with histologically confirmed NAFLD.
Goal(s): Find a non-invasive method for the diagnosis of NASH from NAFLD.
Approach: The data were analyzed using SPSS 26.0 statistical software.
Results: Our findings revealed a positive correlation was observed between NAS scores and the FIR of MF muscle at the L3 level. Remarkably, MF muscle fat infiltration and ALT emerged as independent risk factors for NASH. Moreover, the integration of laboratory indices and radiological parameters in a combined model shows promising potential for the diagnosis of NASH.
Impact: This study has revealed a profound association between PVM muscle radiological parameters and the severity of NAFLD and provided novel avenues for the diagnosis of NASH.
Purpose
This study aims to assess changes in paravertebral muscle (PVM) fat infiltration and multi b-value DWI parameters and their potential correlation with non-alcoholic fatty liver disease (NAFLD) by utilizing IDEAL-IQ and multi b-value diffusion weight imaging (DWI) techniques in patients with biopsy-proven NAFLD.Methods
This retrospective analysis included 178 patients with biopsy-proven NAFLD. The study employed MRI-based IDEAL-IQ and multi-b value DWI sequences to obtain relevant parameters at the L2 and L3 levels of PVM. Differences in PVM fat infiltration ratio(FIR), DWI parameters, and laboratory indices were compared between the NAFLD and non-alcoholic steatohepatitis (NASH) groups. Additionally, the correlation between the FIR and the NAFLD activity score (NAS) was analyzed. Binary logistic regression was used to identify independent risk factors for the occurrence of NASH. The clinical utility of PVM fat infiltration, multi b-value DWI parameters, and laboratory indices in diagnosing NASH in NAFLD patients was evaluated through the construction of receiver operating characteristic (ROC) curves.Results
In the NASH group (n=102), the FIR at the L2 and L3 levels was significantly higher than that in the NAFLD group (n=76) (p<0.05). Additionally, the α and f values at the L3 level of PVM were lower in the NASH group (p<0.05). Moreover, there was a positive correlation between the FIR at the L3 level and the NAS score (0-8 points) (r=0.343, p<0.01). The FIR at the L3 level emerged as an independent risk factor for the occurrence of NASH, along with alanine aminotransferase (ALT). ROC curves constructed using the L3 level PVM radiological parameters and laboratory indices had an area under the curve (AUC) of 0.880 (0.829, 0.931) for diagnosing NASH in NAFLD patients, significantly higher than that for diagnosing NASH using the degree of PVM fat infiltration, multi-b value DWI parameters, and laboratory indices alone (p<0.05).Conclusions
Radiological parameters of the PVM exhibit a correlation with NAFLD. The integrated curve combining PVM radiological parameters and laboratory indices may contribute to distinguishing NASH from NAFLD, offering novel insights into the diagnosis of NASH.Acknowledgements
We thank Minghua Zheng and his team from the First Affiliated Hospital of Wenzhou Medical University for providing NAFLD patients for this study and thank Lu Han from Philips Healthcare, Shanghai for the technical discussion.References
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