Chun-Han Liao1,2,3, Yung-Yin Cheng1,4, Shin-Lei Peng5, Hing-Chiu Chang6, Shao Chieh Lin1,7, Chun-Jung Juan7, Chang-Hsien Liu7, Ya- Hui Lee7, Chao-Chun Lin8, Chia-Wei Lin8, and Yi-Jui Liu9
1Ph.D. program in Electrical and Communication Engineering, Feng Chia University, Taichung, Taiwan, 2Department of Medical Imaging, Yuanlin Christian Hospital, Changhua, Taiwan, 3Department of Medical Imaging, Changhua Christian Hospital, Changhua, Taiwan, 4Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan, 5Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, 6Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 7Department of Medical Imaging, China Medical University Hsinchu Hospital, Hsinchu, Taiwan, 8Department of Radiology, China Medical University Hospital, Taichung, Taiwan, 9Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan
Synopsis
Keywords: Vessels, Diffusion/other diffusion imaging techniques, MUSE, PROPELLER, Meningeal lymphatics vessels
Motivation: Is it possible to water diffusion be measured in meningeal lymphatic vessels (MLVs)?
Goal(s): Diffusion-weighted MRI is employed to assess the circulatory condition of MLVs, eliminating the need for MRI with contrast agent administration, which typically requires monitoring for over 4 hours.
Approach: Water diffusion measurements in MLVs were conducted using MUSE DWI and PROPELLER DWI, which offer low image distortion and high resolution.
Results: Our results indicate that MLVs were clearly visible on high spatial resolution DWI and ADC maps, and the ADC values of MLVs are higher than those of GM and WM but lower than CSF.
Impact: Since evaluating the circulatory condition of
meningeal lymphatic vessels takes over 4 hours by contrast agent injection, our
study investigates the feasibility of assessing the ADC of meningeal lymphatic
vessels using high-resolution MUSE DWI and PROPELLER DWI.
Introduction
The
lymphatic system is a circulation that contributes to facilitating the
clearance of excess fluid and macromolecules from the interstitium. It
accomplishes this by passing through lymph nodes to remove bacteria, abnormal
cells, and other matter [1]. Recently, the brain glymphatic system (GS) [2] and
the meningeal lymphatic vessels (MLVs) [3] have been discovered. The brain GS
collects cerebrospinal fluid (CSF) from the subarachnoid space and brain
interstitial fluid (ISF) through aquaporin-4 (AQP4) water channels. The
meningeal lymphatic vessels (MLVs) situated in the dorsal and basal regions
serve as downstream channels, responsible for draining ISF, macromolecules, and
immune cells out of the cranial cavity. Additionally, they play a crucial role
in regulating immune responses in the brain. Recent research has shown that
ISF, CSF, MLVs, and the brain GS are important factors impacting brain
homeostasis [4].
Using 3D T2-Fluid Attenuated Inversion
Recovery (FLAIR) magnetic resonance imaging, dural lymphatic structures were
demonstrated along the dural venous sinuses in the dorsal regions and along the
cranial nerves in the ventral regions of the human brain [5]. The function of
MLVs and the flux rate of cerebrospinal fluid to the parasagittal dura have
been evaluated using the propagation of tracer with multi-phase T1WI after the
injection of a contrast agent [6]. However, the observation period in multi-phase
T1WIs exceeds 4 hours due to the extremely slow fluid drain in the MLVs.
The function of MLVs can potentially be
evaluated using echo-planar diffusion-weighted imaging (EP-DWI) since the slow
lymphatic drainage is sensitive to water diffusion. Unfortunately, due to the
characteristics of low resolution and image distortion, EP-DWI cannot be
effectively applied to the MLVs. However, 2D spatially-selective RF and
Multiplexed Sensitivity Encoding (MUSE) technique [7] and PROPELLER [8] can
provide diffusion weighted image (DWI) with higher spatial resolution and slight
image distortion. In this study, MUSE DWI and PROPELLER DWI with high
resolution were used to investigate water diffusion in the MLVs.Materials and Methods
Volunteers:
This study conveniently recruited 3 male volunteers aged 23 to 28 years old,
who did not exhibit any symptoms related to brain and cerebral circulation. MRI
scans: MR studies were conducted using 3.0T scanners (SIGNA Architect, GE
Healthcare) with head and neck coils. Table 1 presents the protocols for
T2-FLAIR, MUSE DWI, and PROPELLER DWI sequences. Data processing: ADC maps were
generated by pixel-by-pixel computation from DWI images using the formula SI=SIb0
× e-bD. ADC values were measured within regions of
interest (ROI) encompassing the MLVs, gray matter, white matter, and CSF. Mean
values and standard deviations were calculated for the analysis. The
signal-to-noise ratio (SNR) was determined by dividing the signal mean of the
brain parenchyma by the standard deviation of the air area.Results
The high-resolution T2 FLAIR image and 3D
reconstruction were shown in Figure 1. Figure 2 displayed sagittal view images,
including T2 FLAIR, MUSE DWI, PROPELLER DWI, MUSE ADC map, and PROPELLER ADC
map. Figure 3 displayed the coronal view images. Table 2 listed the DWI SNR for
MUSE and PROPELLER, while Table 3 showed ADC values (mean ± SD) of WM, GM, MLV,
and CSF.Discussion
Because the thickness of the MLV is thin
(0.5~1.5 mm), a high-resolution MRI is necessary for observing MLVs. In this
study, DWI with a voxel size of 0.78×0.78×3 mm was
used to evaluate water diffusion in MLVs. Our results showed that MLVs were
clearly visible on high spatial resolution DWI and ADC map, corresponding to
the T2 FLAIR image, in both MUSE and PROPELLER imaging. The study demonstrated
the feasibility of assessing ADC measurement in MLVs using MUSE DWI and
PROPELLER DWI, which have high spatial resolution and minimal image distortion.
The ADC values of MLVs are intermediate
between those of brain parenchyma (GM and WM) and CSF, as diffusion is
restricted in bound waters such as solids tissue or macromolecules. The
CSF-ISF-CSF washout, originating from the perivenous space, eventually drains
into the MLVs with thin film structure [9]. Consequently, the concentration of
macromolecules in MLVs is higher than that in CSF, due to macromolecular
accumulation and the narrow space within MLVs. In conclusion, the high
resolution of MUSE DWI and PROPELLER DWI allows for the measurement of
diffusion in MLVs, and the ADC values of MLVs are higher than those of GM and
WM but lower than CSF.Acknowledgements
Supported by the Taiwan Ministry of Science
and Technology under grants 110-2221-E-035-016 and Taiwan National Science and
Technology Council under grants 111-2314-B-035 -001 -MY3.References
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