Manoj K Sarma1,2, Mahrshi Jani1, Yeison Rodriguez1, Bei Zhang1,2, and Anke Henning1,2
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2Radiology, UT Southwestern Medical Center, Dallas, TX, United States
Synopsis
Keywords: Spectroscopy, Spectroscopy, Skeletal muscle, SVS, pulse sequence
Motivation: Due to the dependence on the type and orientation of the skeletal muscle, it is a challenge to perform 1H MRS to characterize the muscle features in this highly organized structure.
Goal(s): The aim of this work was to implement a non-water-suppressed semi-LASER (sLASER) sequence to characterize up- and downfield metabolites in human skeletal muscle in vivo at 3T.
Approach: This was achieved through optimizing the crusher scheme and phase cycling schemes in sLASER and combining it with metabolite cycled.
Results: High quality spectra were obtained from different muscle fibers of 8 healthy volunteers to characterize both up- and downfield metabolites.
Impact: We
demonstrated the application of metabolite-cycled semi-LASER spectroscopy in
human skeletal muscles at 3T. Up- and downfield parts of the spectrum were
detected with high quality enabling the detection of important metabolites including
carnosine providing unique insight into human physiology.
Introduction:
Proton (1H) MR spectroscopy (MRS) of
skeletal muscle provides unique insight into human
physiology complementing the information from 31P- and 13C-MRS1.
Depending on the type and orientation of the muscle, 1H MRS spectra
exhibit a mixture of features including residual dipolar couplings. 1H-MRS
permits the assessment of several muscle metabolites in vivo, including
carnosine, which has pathophysiological relevance in multiple diseases. It is
visible in the downfield region of 1H spectra and its quantification
are hindered due to the baseline distortion caused by the water sidebands2
observed in conventional MRS technique like PRESS. Conventional water suppression techniques may also attenuated
these muscle metabolites complicating detection and quantification3.
Further, PRESS technique with
slice selection using standard RF pulses, suffers from a magnetic field strength-dependent chemical
shift displacement (CSD) error, non-uniform
refocusing, and spatially dependent magnetization transfer4. Semi-Localization through Adiabatic SElective Refocusing
(sLASER) has been demonstrated to minimize these artifacts5-7. Here, we present a non-water-suppressed sLASER
sequence to characterize up- and downfield
metabolites in human skeletal muscle in vivo at 3T. This was achieved through
optimizing the crusher and phase cycling schemes in sLASER and combine
it with metabolite cycled
(MC)7 to account for inhomogeneous transmit fields and minimizing
CSD.Materials and Methods:
An asymmetric adiabatic
inversion pulse optimized for MC7 at 3T was incorporated with a crusher
scheme and 16-step phase cycling scheme optimized sLASER to study for both
upfield and downfield metabolites (Figure 1). The characteristics of the inversion
pulse for MC were: pulse duration=22.4 ms, frequency factor=2, and frequency
offset=±200 Hz. The sequence was
evaluated in the skeletal muscle of eight healthy volunteers (age, 20-30 years).
Written informed consent was given by all subjects, and were approved by the institutional
review board.
All data were collected on a 3T Prisma MRI scanner (Siemens, Erlangen, Germany)
using a home-built 2-channel 31P/1H calf coil with two
interleaved birdcages8. Placement of the
spectroscopy voxel was facilitated using a high-resolution 3D-MPRAGE scan9.
The MC-sLASER acquisition
parameters were: voxel size=8-3.375 cm3, TE=4 ms, TR=2 s, averages=64,
1024 spectral points, bandwidths=2000 Hz with scan time ~2.16 min. No OVS was
applied. For comparisons, PRESS spectra were acquired with the same scan parameters
with global water suppression performed using WET10 and TE=30 ms. For
PRESS, a non-water-suppressed scan with one average was also recorded for eddy
current correction and estimation of coil sensitivities. B0 shimming was done
using FAST(EST)MAP11. Acquired data were extracted, reconstructed
and post-processed7 with a library of custom MATLAB-based program. For calculation of the metabolites concentrations, the
spectra were analyzed using LCModel12.Results:
Spectra from the soleus and tibialis
anterior voxel of a volunteer, as acquired with PRESS and MC-sLASER, are
illustrated in Figure 2. Clear differences between the two sequences were observed regarding the shape of the peaks of Creatine-CH2, Taurine, TMA in
soleus and IMCL/EMCL-CH3, IMCL/EMCL-CH2-CH in both soleus and tibialis
anterior. The LCModel fit (Figure 3(A)) shows an almost flat baseline and a
high-quality fit for MC-sLASER from the tibialis anterior of a healthy
volunteer. Except for the Creatine-CH2
and taurine peak all other metabolites were quantified with SD less than 20%
(Figure 3(B)). To test the robustness of mc-sLASER
against experimental imperfections including B0 shim quality, additional spectra
were acquired with automatic
B0 shim mode (Figure 4). Despite
inferior shimming mc-sLASER performed better then PRESS likely due to its lower
chemical shift displacement. The downfield spectrum of a healthy volunteer
acquired using mc-sLASER is demonstrated in Figure 5 showing successful
detection of carnosine C2 and C4 resonances. Discussion:
In this study, an optimized MC-sLASER was
introduced to measure metabolite content from human skeletal muscle at 3T.
Using the MC-sLASER, both the upfield and
downfield parts of the spectrum including resonances that exchange protons with
water were detected with good quality. Compared to PRESS, MC-sLASER
showed better muscle characteristics even with poor shimming. Although a bigger
voxel is suggested1 for the detection of carnosine, we were able to
observe it with MC-sLASER even with a voxel size of 3.375cm3. The
SNR benefit of MC-sLASER is inherent7 in comparison to PRESS and is
a suitable technique for skeletal muscle with its reduced CSD. Further, this
technique can be used to study water magnetization transfer rates in human
skeletal muscle3 which can yield insights into metabolite compartmentation.Conclusion:
In conclusion, this study
has demonstrated the application of metabolite cycled
semi-LASER spectroscopy in human skeletal muscles at 3T. While these initial results are promising, further optimization and validation with a
large pool of human subjects is needed. Future work will address absolute
quantification of carnosine and other observed resonances. Acknowledgements
This work was performed in the Advance Imaging
Research Center at University of Texas Southwestern Medical center Dallas. This
work was supported by Cancer Prevention and Research Institute of Texas (CPRIT)
grant / RR180056.References
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