Hans Hoogduin1, Jason van Schoor2, Fredy Visser3, Peter van der Meulen3, Jurgen Mollink3, Debasish Nayak4, Nithin Jose4, Gerhard Steenkamp4, Aydin Zadeh4, Mark Jacobs4, and Dennis Klomp1
1UMC Utrecht, Utrecht, Netherlands, 2Institute for Biomedical Enginering, ETH Zurich and University of Zurich, Zurich, Switzerland, 3Philips, Best, Netherlands, 4Optics11, Amsterdam, Netherlands
Synopsis
Keywords: New Devices, Hybrid & Novel Systems Technology
Motivation: Detection of vital signs in MRI is hampered by the harsh environment of the MR-scanner and requires setup time.
Goal(s): Use integrated (i.e. no setup time) sensors that are fully MR-compatible and provide reliable cardiac and respiratory signals.
Approach: Fiber Bragg Grating (FBG) based sensors (optical sensors) are integrated into the headrest of an MR-coil and the MR-bed for detection of heart beat and respiratory cycle.
Results: MR-system integrated FBG sensors pick up cardiac and respiratory signals. The challenge lies in the realtime filtering of these signals to be able to use them for triggering of the scanner.
Impact: Patient setup time can be reduced for exams requiring cardiac and/or respiratory signals by using MR-system integrated FBG sensors.
Introduction
Detection of vital signs is often used in MRI.
For example, ECG based heartbeat triggering in cardiac scans. However, the
harsh environment provided by the MR-scanner makes it difficult to monitor
these signals in a consistent and reliable way. Especially the use of ECG is
not straight forward. In addition, these sensors require patient setup time.
Here we propose to use Fiber Bragg Grating (FBG) sensors to detect both
heartbeat and respiratory cycle. The
sensors are integrated in (for now glued on) the MR-bed and, in a second setup,
in the headrest of a head-coil thereby removing the patient setup time. FBG
sensors are based on the reflection of laser light in a short section of Bragg
gratings in an optical fiber. The interrogator, the device providing and
analysing the laser light, can be placed outside the Faraday cage. The absence
of active components in the MR-room, makes them fully MR-compatible. Earlier
attempts [1-3] using this technique did integrate these sensors in dedicated
matrasses which still required some setup time. Here we show initial results
with setups that allow full integration in the MR-scanner.Methods
Methods FBGs were integrated into two parts of an MR-scanner
(Philips, Best): a 7T head-coil and a 3T MR-bed. A single FBG was glued to the
back of the headrest of a head-coil as shown in figure 1. Initial measurements
were done outside the MRI with a subject lying on the floor on a towel in the
headrest. For subsequent measurements a subject was lying with his head on a
cushion in the headrest which was part of an 8 channel transceiver coil (figure1
right) which was used for imaging. Figure 2 shows two other FBGs which were
integrated in a bending design and glued to the MR-bed below the standard
matrass used for patient comfort. The scanners body coil was used for imaging
in this case. An I4G 4 channel interrogator (Optics11, Amsterdam), located in
the control room of the scanner, was connected at the end of approximately 24m optical
fiber. Due to the high reflectivity of the FBG elements, a 5dB inline optical attenuator
was used to prevent the FBG reflection spectra from saturation. FemtoSense 2.3
software (Optics11, Amsterdam) was used to acquire and store the data. The FBGs
showed reflection peaks at ~1550nm (headrest) and ~1533nm and ~1539nm bending
designs with no subject present. The sensitivity of the bending design FBGs was
about 4 nm/kg, for the headrest sensor we could not measure the sensitivity due
to the stiffness of the headrest material. With both setups several MR-scans
were made to see the effect of scanning on the FBG signal. The standard
peripheral pulse unit and respiratory belt signals of the scanner were acquired
and used during a respiratory triggered T2 liver scan at 3T. Results & Discussion
A raw signal trace from a subject lying on the floor in the headrest is
shown in figure 3. Both the respiratory cycle and cardiac pulsation (small
spikes) are clearly visible. The slow drift observed in the data is probably
due to the warming up of the sensor due to the presence of the subject. A raw
signal trace acquired during a T1 3D TFE
sequence is shown in figure 4 together with results obtained after filtering. The
arrows indicate the begin and end of scanning. The sound of the sequence is
easily recognized when playing an mp4 file created from the polynomial fitted
signal. A Fourier transform of the signal (not shown) also shows the main
gradient switching frequencies in the MR-scan. Figure 5 shows data from an FBG beding
design sensor glued on the table during a respiratory gated (by the belt) T2
liver scan. Again the scan segments can be recognized and there is good
alignment between the belt and FBG data. Cardiac pulses are also visible but
alignment with the PPU is somewhat variable (dotted lines). Conclusion & Outlook
The initial results shown in this work demonstrate that FBG sensors
integrated into parts of the MR-scanner are sensitive enough to pick up vital
signs. The comparison with standard MR sensors needs further investigation,
especially the comparison with ECG. Realtime filtering of the FBG signals is
required to use the FBG signal for cardiac and respiratory triggering of the
scanner. Real time wavelet based filters [4] are currently being explored and
implemented for this purpose.Acknowledgements
No acknowledgement found.References
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[4] Lukas
P. A. Arts and Egon. L. van den Broek. Nature Computational Science, VOL
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