Synopsis

Keywords: Neuro: Brain

Receptor PET imaging allows for unparalleled insights in the physiological and metabolic processes of neuroinflammation. PET radioligands targeting TSPO are the most developed and their utility has been shown in literature in a wide range of neurodegenerative and psychiatric diseases. More recently, a number of promising PET radioligands for alternative inflammation targets are being developed. When interpreting receptor PET imaging, caution is needed in carefully considering appropriate modeling approaches and distribution and expression of target receptors in the pathology of interest.