Neuromodulation to Treat Epilepsy
Axel Thielscher1,2
1Technical University of Denmark, Copenhagen, Denmark, 2Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Amager and Hvidvore, Hvidvore, Denmark

Synopsis

Keywords: Neuro: Brain, Neuro: Brain Plasticity

A number of different brain stimulation methods are currently tested as adjunct therapies for drug-refractory epilepsy. This talk will start by giving an overview of the relevant invasive and noninvasive electric stimulation approaches. It will discuss the mechanisms of action by which the stimulation approaches are thought to alter cortical activity, and briefly summarize the data on their clinical efficacy and safety. Finally, current methodological advances to personalize the interventions based on structural and functional MRI data as well as calculations of the induced electric field distributions will be highlighted.

A number of different brain stimulation methods are currently tested as adjunct therapies for drug-refractory epilepsy. This talk will start by giving an overview of the relevant invasive and noninvasive electric stimulation approaches. It will discuss the mechanisms of action by which the stimulation approaches are thought to alter cortical activity, and briefly summarize the data on their clinical efficacy and safety. Finally, current methodological advances to personalize the interventions based on structural and functional MRI data as well as calculations of the induced electric field distributions will be highlighted.

Acknowledgements

The author received support by the Lundbeck Foundation (grants R313-2019-622 and R244-2017-196).

References

No reference found.
Proc. Intl. Soc. Mag. Reson. Med. 31 (2023)