Keywords: Neuro: Neurodegeneration, Neuro: Brain
For data collected from multiple sites, the resulting features can be difficult to interpret due to site-specific effects. Nonetheless, for certain studies, such as those requiring a large number of participants, it may be necessary to obtain data from multiple scanners. Thus, harmonization methods have been developed to correct for site effects while still preserving the biological variability in the data. However, several challenges must be carefully considered, including the minimum sample size required and differences in data acquisition procedures. In this presentation, I will discuss these challenges in detail and offer strategies for successful MRI harmonization in multisite studies.