ASL Clinical Applications & Implementation
Sergio Manuel Solis-Barquero1
1Radiology Dep., Clinica Universidad de Navarra, Pamplona, Spain

Synopsis

Keywords: Contrast mechanisms: Perfusion, Body: Body

The objective of this talk is to introduce and provide an overview of the current state-of-the-art of ASL applications in the human body. The talk will focus on the research in perfusion studies in kidneys, lungs, heart, liver, pancreas, and spleen. The talk will describe ongoing challenges and recommendations that aim to enable more widespread use of the technique in clinical practice and its eventual implementation. Upon attendance, the audience should have a basic understanding of the techniques used for ASL body perfusion imaging.

This talk is part of the Advanced MR Abdominal Imaging Techniques and Their Clinical Application in the ISMRT Multilingual Session: Spanish/English.
The talk will start with a brief introduction on ASL MRI perfusion imaging and data acquisition in the human brain, summarizing principal labeling strategies: PASL and PCASL. Later, the talk will focus on the research in perfusion studies outside of the brain and the current developed abdominal applications. Specifically, the talk will summarize ASL perfusion studies in kidneys, lungs, heart, liver, pancreas, and spleen. The talk will describe general challenges and recommendations in these techniques. Not all of the current techniques have a widespread use, and most of them have sparse research. None of them have a current clinical application or published consensus or guideline. The aim is to enable more widespread use of the technique in clinical practice and its eventual implementation. Upon attendance, the audience will have a basic understanding of the techniques used for ASL body perfusion imaging.

Objectives

  • Introduce the different techniques used for the acquisition of human perfusion imaging using arterial spin labeling (ASL) outside the brain.
  • Summarize the current state-of-the-art of arterial spin labeling applications for human perfusion imaging in different organs.
  • Describe ongoing challenges and recommendations for the implementation of the ASL for the human body perfusion in the clinical practice.

Acknowledgements

SSB receives PhD funding from Fundación Carolina and the Universidad de Costa Rica.

References

Taso M, Aramendía-Vidaurreta V, Englund EK, et al. Update on state-of-the-art for arterial spin labeling (ASL) human perfusion imaging outside of the brain. Magn Reson Med. 2023;89(5):1754-1776. doi:10.1002/mrm.29609

Aramendía-Vidaurreta V, Solis-Barquero SM, Ezponda A, et al. Assessment of Splenic Switch-Off With Arterial Spin Labeling in Adenosine Perfusion Cardiac MRI [published online ahead of print, 2022 Oct 11]. J Magn Reson Imaging. 2022;10.1002/jmri.28460. doi:10.1002/jmri.28460

Aramendía-Vidaurreta V, Echeverría-Chasco R, Vidorreta M, Bastarrika G, Fernández-Seara MA. Quantification of Myocardial Perfusion With Vasodilation Using Arterial Spin Labeling at 1.5T. J Magn Reson Imaging. 2021;53(3):777-788. doi:10.1002/jmri.27396

Echeverria-Chasco R, Vidorreta M, Aramendía-Vidaurreta V, et al. Optimization of pseudo-continuous arterial spin labeling for renal perfusion imaging. Magn Reson Med. 2021;85(3):1507-1521. doi:10.1002/mrm.28531

Proc. Intl. Soc. Mag. Reson. Med. 31 (2023)