Synopsis

Keywords: Physics & Engineering: Preclinical MRI, : Preclinical/Animal

Preclinical MRI is a key resource for translational research. It allows researchers to bring basic science to the benefit of patients, and to test and validate hypotheses derived from clinical research in animal models. The ability to use the same MRI methods and pulse sequences in clinical and preclinical scanners is a major advantage not available with other approaches. However, differences in sample size create possible difficulties in preclinical MRI. In this presentation, we will discuss the major challenges and benefits of preclinical MRI and showcase real-world applications, including preclinical research conducted in regions of the world with varying resources.

Preclinical MRI is an important tool in translational research, bridging the gap between basic science and clinical applications. By utilizing animal models, hypotheses can be tested and validated using causal interventions that can’t be achieved in humans, such as genetic manipulations and invasive procedures. This allows, for example, the development and validation of MRI methods, a better understanding of MRI signals, and translational outcomes that could lead to improvements in patient care. Among different animal models, rodents, and in particular mice, are most commonly studied in preclinical research. Mice have many similarities to humans including organ structure, physiology and genetics, are easy to care for, and can be scanned with MRI both in vivo and post-mortem. One of the major advantages of preclinical MRI is the ability to use the same imaging methods and pulse sequences across preclinical and clinical scanners, providing a potentially seamless transition from bench to bedside. However, preclinical MRI has its own set of challenges, such as the need for increased spatial resolution and specialized hardware to improve signal-to-noise ratios in smaller sample sizes. In addition, access to preclinical scanners may be limited in certain regions of the world due to cost or infrastructure limitations. In this presentation, the major benefits and challenges of preclinical MRI will be explored, and real-world applications will be presented, including preclinical research conducted in different regions of the world with varying resources.

Acknowledgements

Thanks to Khallil Chaim, Daniel Papoti, Maria Concepcion Garcia Otaduy, Roberson Polli, Jackeline Malheiros, Alberto Tannús, Pierre Carlier, Jason Lerch, Mohamed Tachrount, Clémence Ligneul, Cristiana Tisca and Karla Miller for contributing to the content of this presentation.

References

No reference found.