Synopsis

Keywords: Contrast mechanisms: CEST & MT

CEST MRI has been increasingly explored and applied in multiple preclinical and clinical imaging centers worldwide. This lecture will introduce some recent progress and consensus on the clinical application of CEST MRI, especially the considerations regarding saturation and acquisition protocols to achieve high-quality and reproducible CEST measurements at multiple sites. Furthermore, there will be some discussions on the clinical trials using endogenous or exogenous CEST contrasts to provide molecular information for disease diagnosis and treatment monitoring. Specifically, a variety of CEST applications in imaging molecular events in brain tumors, neurological disorders and other parts of human body will be covered.

Overview

Chemical exchange saturation transfer (CEST) MRI is a molecular imaging technique that enables the detection of compounds with exchangeable protons. CEST MRI has been increasingly explored and applied in multiple preclinical and clinical imaging centers worldwide. This lecture will introduce some recent progress and consensus on the clinical application of CEST MRI, especially the considerations regarding saturation and acquisition protocols to achieve high-quality and reproducible CEST measurements at multiple sites. Furthermore, there will be some discussions on the clinical trials using endogenous or exogenous CEST contrasts to provide molecular information for disease diagnosis and treatment monitoring. Specifically, a variety of CEST applications in imaging molecular events in brain tumors, neurological disorders and other parts of human body will be covered. Finally, the remaining challenges in the clinical application of CEST MRI will be briefly discussed.

Acknowledgements

No acknowledgement found.

References

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