Metabolites by MRS/MRSI
Esin Ozturk-Isik1
1Bogaziçi University, Turkey

Synopsis

Keywords: Contrast mechanisms: Spectroscopy

Magnetic resonance spectroscopic imaging (MRS/I) provides metabolic markers that could be employed for improved patient management. This talk will summarize the challenges of MRS/I, recent advances for a more standardized approach, machine learning studies for improved MRS/I, and the importance of quantitative metabolic markers of the brain and other body parts in the clinics.

Objective: To provide an overview of efforts to advance and standardize magnetic resonance spectroscopic imaging (MRS/I), which provides metabolic markers that could be used for improved patient management.

Course Summary: Magnetic resonance spectroscopic imaging (MRS/I) provides a noninvasive probe into the biochemical properties of the tissue. Proton MRS (1H-MRS) is the most commonly used technique to detect several metabolites, including choline (Cho), creatine (Cr), N-acetyl-aspartate (NAA), glutamate (Glu), glutamine (Gln), gamma-aminobutyric acid (GABA), glutathione (GSH), myo-inositol (mI), lactate (Lac), lipid (Lip), citrate (Cit), and more recently oncometabolite 2-hydroxyglutarate (2HG) [1, 2]. Despite its enormous potential, there have been some challenges preventing a wider use of MRS/I in the clinical settings, including issues with robust quantification, reproducibility and standardization. As a result, there have been recent consensus recommendations for a more standardized MRS methodology to enable a wider use of MRS/I [3-7]. Additionally, machine learning has been applied for improved MRS/I data acquisition and reconstruction [8-12], preprocessing [13], and spectral quantification [14, 15]. This talk will cover the challenges of MRS/I, recent advances for standardization and machine learning applications, and the importance of quantitative metabolic markers for imaging the brain and some other body parts towards precision medicine.

Acknowledgements

TUBITAK grants 119S520 and 216S432.

References

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Proc. Intl. Soc. Mag. Reson. Med. 31 (2023)