Synopsis

Keywords: Neuro: Brain, Contrast mechanisms: Diffusion, : Preclinical/Animal

The brain tissue has a complex microstructural environment, which is averaged in the coarse resolution of MRI. In this talk, we will explore the potential of conventional and advanced histological methods, e.g., light or electron microscopy, offering a variety of tissue information at higher resolution than diffusion MRI. We will talk about extracting quantitative information or 3D modeling of brain tissue microstructure relevant to diffusion MRI. We will discuss how to develop strategies for validation using a multimodality approach and what are the benefits and challenges of combining histological information with greater sensitivity and the coarse information of diffusion MRI.