Quantitative Echo Planar Time-Resolved Imaging

Fuyixue Wang^1,2
¹Athinoula A. Martinos Center for Biomedical Imaging, MGH, Charlestown, MA, United States, ²Department of Radiology, Harvard Medical School, Charlestown, MA, United States

Synopsis

Keywords: Image acquisition: Sequences, Image acquisition: Multiparametric, Contrast mechanisms: Diffusion

EPTI is a novel distortion-free imaging technique that addresses the limitations of EPI while providing efficient multi-contrast imaging. EPTI recognizes the spatiotemporal data correlation during the image encoding process, and exploits it to replace conventional image formation and efficiently resolve the full spatiotemporal space. The high efficiency, improved image quality, and rich information of EPTI provide exciting opportunities for quantitative imaging. This talk will provide a comprehensive review of EPTI, its related technologies, and their applications in quantitative imaging. It will present EPTI’s concept, acquisition and reconstruction, followed by applications in multi-parametric mapping, diffusion MRI, myelin water, and functional imaging.

Abstract

EPTI¹ is a novel imaging technique that addresses the limitations of conventional EPI acquisition, such as distortion and blurring, while providing efficient multi-contrast multi-echo imaging. EPTI recognizes the strong spatiotemporal data correlation during the image encoding process, and exploits it to replace conventional image formation and efficiently resolve the full spatiotemporal space. The high efficiency, improved image quality, and rich information of EPTI provide many exciting opportunities for quantitative imaging.
This talk will provide a comprehensive review of EPTI, its related technologies, and their applications in quantitative imaging. It will first provide a technical overview of the EPTI method, including the concept, acquisition, reconstruction, and data processing of EPTI^1-2. It will then present EPTI’s applications in quantitative imaging, including multi-parametric mapping^3-4, diffusion MRI^5-11, myelin water imaging¹², and functional imaging^13-14. Finally, recent development and other extensions will also be reviewed.

Acknowledgements

No acknowledgement found.

References

1. Wang F, Dong Z, Reese TG, Bilgic B, Katherine Manhard M, Chen J, Polimeni JR, Wald LL, Setsompop K. Echo planar time-resolved imaging (EPTI). Magn Reson Med. 2019 Jun;81(6):3599-3615.

2. Dong Z, Wang F, Reese TG, Bilgic B, Setsompop K. Echo planar time-resolved imaging with subspace reconstruction and optimized spatiotemporal encoding. Magn Reson Med. 2020 Nov;84(5):2442-2455.

3. Wang F, Dong Z, Reese TG, Rosen B, Wald LL, Setsompop K. 3D Echo Planar Time-resolved Imaging (3D-EPTI) for ultrafast multi-parametric quantitative MRI. Neuroimage. 2022 Apr 15;250:118963.

4. Dong Z, Wang F, Setsompop K. Motion-corrected 3D-EPTI with efficient 4D navigator acquisition for fast and robust whole-brain quantitative imaging. Magn Reson Med. 2022 Sep;88(3):1112-1125.

5. Dong Z, Wang F, Wald L, Setsompop K. SNR-efficient distortion-free diffusion relaxometry imaging using accelerated echo-train shifted echo-planar time-resolving imaging (ACE-EPTI). Magn Reson Med. 2022 Jul;88(1):164-179.

6. Wang F, Dong Z, Polimeni JR, Lee H, Huang SY, Wald LL, High-SNR whole-brain microstructure diffusion MRI using Romer-EPTI, In Proceedings of the 31st Annual Meeting of ISMRM, 2023.

7. Dong Z, Polimeni JR, Wald LL, and Wang F, Mesoscale distortion-free in-vivo dMRI at 7T using ROtating-view Motion-robust supEr Resolution EPTI (Romer-EPTI), In Proceedings of the 31st Annual Meeting of ISMRM, 2023.

8. Dong Z, Polimeni J, Wald LL, Wang F. SuperRes-EPTI: in-vivo mesoscale distortion-free dMRI at 500μm-isotropic resolution using short-TE EPTI with rotating-view super resolution. In Proceedings of the 30th Annual Meeting of ISMRM, 2022, p. 3488.

9. Fair MJ, Wang F, Dong Z, Reese TG, Setsompop K. Propeller echo-planar time-resolved imaging with dynamic encoding (PEPTIDE). Magn Reson Med. 2020 Jun;83(6):2124-2137.

10. Dai E, Lee PK, Dong Z, Fu F, Setsompop K, McNab JA. Distortion-free diffusion imaging using self-navigated Cartesian Echo-planar time resolved acquisition and joint magnitude and phase constrained reconstruction. IEEE Transactions on Medical Imaging. 2021 Aug 12;41(1):63-74.

11. Fair MJ, Liao C, Manhard MK, Setsompop K. Diffusion‐PEPTIDE: Distortion‐and blurring‐free diffusion imaging with self‐navigated motion‐correction and relaxometry capabilities. Magnetic Resonance in Medicine. 2021 May;85(5):2417-33.

12. Dong Z, Wang F, Chan KS, Reese TG, Bilgic B, Marques JP, Setsompop K. Variable flip angle echo planar time-resolved imaging (vFA-EPTI) for fast high-resolution gradient echo myelin water imaging. Neuroimage. 2021 May 15;232:117897.

13. Wang F, Dong Z, Wald LL, Polimeni JR, Setsompop K. Simultaneous pure T2 and varying T2'-weighted BOLD fMRI using Echo Planar Time-resolved Imaging for mapping cortical-depth dependent responses. Neuroimage. 2021 Dec 15;245:118641.

14. Wang F, Dong Z, Chen J, Setsompop K, Polimeni J, Wald LL. Improving fMRI acquisition using single-shot EPTI with distortion-free high-SNR high-CNR multi-echo imaging. In Proceedings of the 30th Annual Meeting of ISMRM, 2022, p. 3330.

15. Liberman G, Wang F, Dong Z, Setsompop K. Spiral Crisscrossing Echo Planar Time-resolved Imaging (SCEPTI). In Proceedings of the 28th Annual Meeting of ISMRM, 2020, p. 0616.

16. Liberman G, Wang F, Dong Z, Setsompop K. Flexible model-based reconstruction through generalized cycled parameter splitting approach. In Proceedings of the 28th Annual Meeting of ISMRM, 2020, p. 0884.

Figures

Echo Planar Time-resolved Imaging for quantitative MRI.

Proc. Intl. Soc. Mag. Reson. Med. 31 (2023)