Keywords: Contrast mechanisms: Diffusion
Diffusion MRI sensitises the signal to the random motion of water molecules by applying diffusion encoding gradients. This talk will give a brief introduction on diffusion MRI and various quantitative measures that can be derived from diffusion MRI signal representations and biophysical models. Stronger gradients can yield shorter echo time, higher signal-to-noise ratio, and shorter diffusion times for a given b-value, and the benefits will be highlighted. Finally, the applications where strong gradients have shown benefits in fundamental and clinical research are explored.