Synopsis

Keywords: Contrast mechanisms: Relaxometry

T1 and T2 relaxation: biophysical basis, quantification techniques, limitations & applications.

Syllabus

Attendees will learn about the physical principles governing longitudinal and transverse relaxation (T1 and T2), as well as their biological correlates. The various techniques for measuring T1 and T2 will be explored, along with their respective limitations. Finally, the application of T1 and T2 mapping in the study of the in-vivo human brain will be presented.

T1:

• The physical basis of T1 relaxation.
• The biological basis of T1 relaxation.
• Measuring T1: inversion recovery, variable flip angles.
• Limitations in T1 mapping: B1 inhomogeneities, sensitivity to multiple biological sources.
• T1 applications.

T2:

• The physical basis of T2 (and T2*) relaxation.
• The biological basis of T2 relaxation.
• Measuring T2: spin-echo and variations on spin echo.
• Limitations in T2 mapping: inhomogeneities, stimulated echoes.
• T2 applications: myelin water fraction.

Acknowledgements

No acknowledgement found.

References

No reference found.