Keywords: Neuro: Nervous system
The talk will focus on agents utilized for magnetic resonance spectroscopy and magnetic resonance imaging in advanced brain metabolic studies. 17O-MRS provides rate of oxygen inside mitochondria, whereas 19F-MRS enables measurement of cytosolic glucose metabolism. 13C-MRS is the only established noninvasive method to quantify both glutamatergic neurotransmission and cell-specific energetic pathways based on the type of 13C-enriched tracer. MRS utilizing deuterium(2H)-enriched compounds is a novel approach that promises to overcome 13C-MRS providing quantitative metabolic measures with high spatial resolution and affordable price. Overall, these MR methods demonstrate clinical translational potential to better understand brain disorders and guide diagnosis and treatment.