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The conspicuity of inner ear membranous labyrinth anatomy using 3D FLAIR without gadolinium contrast agent
Zongrui Zhang1, Zhaohui Liu1, and Yantao Niu1
1Radiology, Beijing Tongren Hospital,Capital Medical University, Beijing, China

Synopsis

Optimized 3D-FLAIR imaging can visualize inner ear membranous labyrinth anatomy without gadolinium contrast agent,paving the way toward developing a simple and quick method for diagnosing Meniere’s disease.

Abstract

Objectives 3D-fluid attenuation inversion recovery(FLAIR) imaging of inner ear collected 4h after intravenous gadolinium injection is the current method commonly used to delineate the endolymphatic hydrops, the pathological feature of Ménière’s disease. We aimed to optimize visualization of inner ear membranous labyrinth anatomy using 3D-FLAIR without gadolinium contrast agent. Methods 10 healthy subjects were scanned at 3.0T MRI with unenhanced 3D-FLAIR using variable inversion times(TIs)（from 1500 to 2100 ms）and high resolution 0.6 mm isotropy. The contrast between PLS and ELS, the contrast between PLS and brainstem, the contrast between ELS and brainstem, SNR, CNR, texture feature information were assessed. Two senior radiologists performed subjective evaluation on the images of 10 healthy subjects. Additionally, pre-contrast 3D-FLAIR with the optimal setting was tested in 10 Meniere patients and compared with contrast-enhanced 3D-FLAIR.The diagnosis efficacy of two methods was evaluated by two senior radiologists. Results The PLS and ELS were best delineated in 100% cases with TI=2100ms at clinical use resolution. Visualization of PLS and ELS in the optimized pre-contrast 3D-FLAIR was similar to conventional contrast-enhanced 3D-FLAIR in 10 MD patients. Conclusions High TI in unenhanced 3D-FLAIR could separate PLS and ELS of the inner ear membranous labyrinth, paving the way toward developing a simple and quick method for diagnosing Meniere’s disease.

Acknowledgements

No acknowledgement found.

References

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Proc. Intl. Soc. Mag. Reson. Med. 31 (2023)
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DOI: https://doi.org/10.58530/2023/5413