Andres Saucedo1,2 and M. Albert Thomas1,2
1Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, 2Physics and Biology in Medicine Interdepartmental Graduate Program, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States
Synopsis
Keywords: Diffusion/other diffusion imaging techniques, Spectroscopy, Spectroscopic Imaging
We present the first demonstration of single shot diffusion trace spectroscopic imaging using radial echo planar
k-space trajectories on a clinical 3T scanner. Conventional DW-MRS requires three
separate acquisitions to compute the trace apparent diffusion coefficient (ADC), whereas the single shot technique generates
a trace-weighted signal in one measurement, although this has so far only been applied in NMR and to a limited extent in DW-MRI. Our preliminary results indicate
good agreement with expected trace ADC values both in phantom and in healthy brain,
showing a promising approach for determining the orientation-independent trace
ADC value with non-Cartesian diffusion-weighted spectroscopic imaging.
Introduction
Diffusion-weighted magnetic resonance spectroscopy measures the diffusion properties of metabolites at the intracellular level,
in contrast to DW-MRI. Several studies have reported diffusion-weighted
spectroscopic imaging (DW-MRSI) using phase encoding alone1 or echo planar k-space trajectories (EPSI)2,3. Single
voxel DW-MRS approaches require shot-to-shot phase and frequency
corrections to accurately determine the apparent diffusion
coefficient (ADC)4,5. Previous reports using Cartesian EPSI have implemented a separate navigator echo to monitor the signal for retrospective corrections6,7.
Radial trajectories (REPSI) allow for self-navigation and
motion robustness8,9 due to their repeated traversal of the central k-space. The trace ADC provides an
orientation-independent quantity that avoids measurement bias from
diffusion anisotropy. Conventional DW-MRSI require at least three separate
measurements to compute the trace ADC. However, the single-shot technique
measures a trace-weighted signal in one measurement, although it has
only been applied in NMR10,11,12 and to a limited extent in DW-MRI13,14.
In this study, we show preliminary results of single shot trace DW-REPSI at 3T in
both phantom and in vivo.Methods
The DW-REPSI sequence applied
volumetric excitation with four pairs of bipolar diffusion gradients along all
axes interleaved with the slice-selective RF pulses (Figure 1). This particular
configuration eliminates the bias due to cross terms between any background and
diffusion gradients, and generates a diffusion trace-weighted signal in a
single measurement11. A symmetric bipolar gradient readout was
used to acquire kr-t data with spectral width of 1190Hz and 512
time points. The field-of-view was 32×32
cm2 with matrix size=32×32. The volume-of-interest (VOI) was 10×10×1.5
cm3 and 12×8×2 cm3, with voxel volumes of 1×1×1.5
cm3 and 1×1×2 cm3 for the phantom and in vivo data,
respectively. The diffusion gradient had 1.5ms ramp time and 7.5ms total lobe duration, with 4.5ms between the bipolar pair, giving a diffusion time of
10.2ms.
Gradient
delay15 and EPI phase corrections16 were applied before extracting the central radial k-space point (k0)
of each spoke for all time points to build a navigator signal, which was then used
to phase and frequency align each average and spoke before NUFFT-based
reconstruction. Water reference data for both phantom and in vivo experiments
were acquired with 1 and 2 averages for low and high b-values, respectively,
and were used for eddy current phase correction, coil combination, and water ADC estimation.
Five
data sets were acquired in a phantom containing Lac, NAA, Glu, Cr, Cho, and mI.
Two b-values were measured (3 and 1,411 s/mm2), using TR=2.2s,
TE=150ms, 34 spokes with golden-angle distribution, and 4 and 8 averages for
the low and high b-values, respectively. The mean phantom ADC values were determined in
5 regions within the 10×10 VOI matrix to determine the homogeneity of ADC values.
In vivo
brain data from four healthy volunteers were measured using TR=2.2s, TE=142ms and two b-values – a low value ranging from 3-72 and a
higher one between 1,000 – 1,231 s/mm2, corresponding to gradient
amplitudes of 0-15 and 54.5-60 mT/m, respectively. For in vivo data, the maximum
b-value was reduced to obtain sufficient SNR due to the long TE and greater motion-related signal losses. Also, 31
spokes with a uniform angular distribution were acquired with 6 and 12 averages
for the low and high b-values, respectively, to limit the total scan time to 24 minutes. All data was quantified using LC Model17, and peak
volumes with CRLB’s ≤ 30% considered for ADC calculation. Results
The trace
ADC values computed from single shot trace DW-REPSI phantom acquisitions agree
well with reference values18 (Figure 3). Trace ADC maps of all six
metabolites (Figure 2) show fairly homogenous values for NAA, Cr, and Cho across
the VOI, although there are small fluctuations which can be attributed to B0
and B1 inhomogeneity and chemical shift displacement. The trace ADC
values for mI, Glu, and Lac in the phantom have larger standard deviations,
although the mean values for mI and Glu are within range of the reference
values. Lactate ADC’s are overestimated by approximately 31%.
Due to the
long TE, only total Cr, total NAA, and total Cho were able to be reliably
estimated in the in vivo data. Figure 4
shows trace ADC maps and voxel-by-voxel values of these three metabolites and
water in one healthy volunteer. Because of the short diffusion time of 10.2 ms,
the measured trace ADC’s are slightly higher than those determined by using
diffusion-weighted MRS sequences with longer diffusion times5,19,20,21. Discussion and Conclusion
The main limitations of single-shot DW-REPSI
are: (1) the long TE necessary for interleaving diffusion gradients with the
localization pulses, limiting the number of detectable metabolites
(i.e., NAA, Cr, & Cho), and (2) the large gradient amplitudes necessary to
achieve sufficient diffusion-weighting but which induce stronger eddy current
effects and greater hardware demands. The main advantage is the reduction of measurement time for trace ADC estimation, compared to other sequences
that require separate measurements along three orthogonal diffusion directions.
Preliminary results show good agreement in the estimated phantom ADC values,
while the in vivo trace ADC’s are generally within the expected range although
the values tend to be slightly higher than previously reported due to the short
diffusion time of 10.2 ms which had not yet been shown for DW-MRSI in humans19,20. Acknowledgements
The authors are very grateful to Dr.
Julien Valette for providing valuable insights on the single shot diffusion trace
pulse sequence and on the effect of short diffusion times on in vivo ADC measurements. The authors also recognize and thank Dr. Itamar Ronen and Dr. Francesca
Branzoli for their earlier support in our group’s initial investigations into single
voxel diffusion-weighted spectroscopy. References
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