Synopsis

Keywords: Pelvis, Cancer, Ovarian cancer

The aim of our study was to compare the differential diagnostic efficacy of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI), apparent diffusion coefficient (ADC), serum carbohydrate antigen 125 (CA125), human epididymal secretory protein 4 (HE4) and their combined application in benign and malignant ovarian tumors, and to explore the best method for the diagnosis of ovarian tumors.

Introduction

The aim of this study was to evaluate the differential diagnostic efficacy of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI), apparent diffusion coefficient (ADC), serum carbohydrate antigen 125 (CA125), human epididymal secretory protein 4 (HE4) and their combined application in benign and malignant ovarian tumors, and to explore the best method for the diagnosis of ovarian tumors.

Methods

68 patients with ovarian tumors admitted to our hospital from January 2022 to September 2022 were enrolled in this retrospective analysis. 32 patients were confirmed as benign and 36 patients as malignant by pathology. All the MR scanning contained DCE-MRI and DWI sequences were performed on a 3T MR scanner (MAGNETOM Skyra, Siemens Healthineers, Erlangen, Germany). The DCE-MRI quantitative parameter Ktrans, semi quantitative parameter TTP were acquired after processing on the post-processing workstation(Syngo Via, Siemens Healthcare). The ADC map was generated after finished DWI scanning automatically. ADC values were obtained by sketching on the ADC maps, and the CA125 and HE4 indicators were retrieved through the LIS system for statistics. At the same time, the sensitivity and specificity of different examination methods and combined application to benign and malignant ovarian tumors were calculated based on the pathological diagnosis results as the gold standard.

Results

The sensitivity of Ktrans, TTP, ADC, CA125 and HE4 in the diagnosis of ovarian benign and malignant tumors was 91.7%, 69.4%, 83.3% and 72.2% respectively, and the specificity was 87.5%, 93.6%, 75.0% and 90.6% respectively. The sensitivity and specificity of the combined application were 100% and 96.9% respectively in the diagnosis of ovarian malignant tumors; There was a statistical difference in the diagnostic efficacy of their respective and combined use for benign and malignant ovarian tumors (P<0.05).

Conclusion

The sensitivity and specificity of DCE-MRI combined with ADC, CA125 and HE4 in differential diagnosis of benign and malignant ovarian tumors were higher than using single examination method alone, which has higher clinical application value.

Acknowledgements

No acknowledgement found.

References

No reference found.