Yonni Friedlander1,2, Dante P.I. Capaldi3, Norm Konyer1, Melanie Kjarsgaard2, Carmen Venegas2,4, Parameswaran Nair2,4, and Sarah Svenningsen1,2,4
1Imaging Research Centre, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 2Firestone Institute of Respiratory Health, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 3Deparment of Radiation Oncology, University of California San Francisco, San Francisco, CA, United States, 4Division of Respirology, McMaster University, Hamilton, ON, Canada
Synopsis
Keywords: Data Analysis, Lung
Using free-breathing
1H MRI, diaphragm excursion was measured in 9 patients with severe asthma at two visits 4-months apart. At each visit, patients with asthma were imaged before and after administration of a bronchodilator. Diaphragm excursion measured at the two visits were not significantly different from one another (mean bias=0.34cm, p=0.07) and were well correlated (r=0.53, p=0.004), demonstrating repeatability of the measurement. In addition, diaphragm excursion was significantly increased following bronchodilator administration (p=0.01).
Introduction
Asthma is a
chronic airways disease characterized by smooth muscle dysfunction and/or
inflammation that contribute to airflow limitation and gas trapping. The
diaphragm is the primary muscle of respiration. It increases the thoracic
volume during inspiration, drawing in air to the lungs. Disease associated with
airflow limitation and gas trapping can lead to overwork of the respiratory
muscles and decrease the range of motion of the diaphragm, which may contribute
to dyspnea1,2. In
addition to the commonly used clinical imaging modalities, such as chest
radiographs and fluoroscopy, diaphragm shape and movement can be imaged using
static or time-resolved CT or MRI3. In this
pilot study, we evaluate the repeatability of diaphragm excursion measurements
in patients with severe asthma using free-breathing 1H MRI. In
addition, we measure the effect of bronchodilator administration on diaphragm
excursion.Methods
Study Design and Participants
Nine patients
with severe asthma performed free-breathing 1H MRI before and after
administration of a bronchodilator at two visits completed 4 months apart. All
patients with asthma were managed by a respiratory physician, had severe
disease according to Global Initiative for Asthma guidelines, were >18 years
of age, and were never or former smokers with less than a 10 pack-year smoking
history. Patients withheld short-acting
β-agonists for ≥6 hours, long-acting β-agonists for ≥48 hours and long-acting
muscarinic antagonists for ≥72 hours prior to each study visit.
MRI Acquisition
and Analysis
All MR
examinations were performed in the coronal plane using a whole body 3.0 Tesla
Discovery MR750 system (GE Healthcare, Milwaukee, Wisconsin, USA). Each
participant underwent free-breathing 1H MRI with respiratory
bellows to monitor respiratory rate and an optimized
balanced-steady-state-free-precession (bSSFP) sequence (acquisition time=160-200s;
echo-time/repetition-time/flip angle=0.6ms/1.9ms/15°; field-of-view=40×40cm2;
bandwidth=250kHz; matrix=256×256; number-of-slices=13-15). Free-breathing 1H
MRI was analyzed and sorted to 10 breath-cycle phases as previously described4,5, using
MATLAB R2019a (Mathworks, Natick, Massachusetts, USA).
Measurement
of diaphragm excursion was performed on the centre slice (±1) of each
acquisition, as identified by the location of the carina. For each phase in the
breathing cycle, the top of the left and right diaphragms were independently
identified using the Canny edge detection technique6. The
diaphragm position was measured as the highest point in the caudal-cranial
direction. Diaphragm excursion was then calculated as the maximum change in the
diaphragm position during the breathing cycle. To measure the effect of
bronchodilator inhalation, the excursions of the left and right diaphragms were
averaged together.
Statistical analysis was performed using GraphPad Prism 9.4.1 (GraphPad
Software, La Jolla, CA). To measure
repeatability, a Pearson correlation of the diaphragm excursion pre- and
post-bronchodilator administration of each lung at visit 2 as a function of
visit 1 was measured and a Bland-Altman analysis was performed. A paired t-test
was used to measure the effect of bronchodilator on diaphragm excursion. Three
acquisitions were excluded due to motion blurring and one patient was not
scanned post-bronchodilator administration.Results
Figure 1
shows a representative image of the lungs in greyscale with the diaphragms
identified by the white lines. The tops of the diaphragms are identified by the
plus symbols. As shown in Figure 2, diaphragm excursion measured at baseline
and 4-months were not significantly different from one another (mean bias=0.34cm;
95% limits of agreement=-1.5cm to 2.2cm; p=0.07) and were correlated
(r=0.53, p=0.004). Figure 3 shows that, following bronchodilator administration,
diaphragm excursion significantly increased by 0.37±0.40 cm (p=0.01).Discussion
Our results
demonstrate that repeatable measurements of diaphragm excursion can be derived
from free-breathing 1H MRI in patients with severe asthma. We do
note that the agreement between diaphragm excursion measured at baseline and
4-month rescan was not perfect. In addition to measurement error, there are
several possible physiological explanations for this. During the 4-month study
period, 7 of 9 patients had one or more asthma exacerbations that led to
treatment changes and variability in symptoms and disease control between study
visits. The bias towards reduced diaphragm excursion at 4-months may reflect worsening
of the diaphragm’s range of motion over the course of the study.
We also demonstrate
the sensitivity of diaphragm excursion measured by free-breathing 1H
MRI to changes in lung physiology following bronchodilator administration.
Diaphragm excursion was increased following bronchodilator administration,
which may be the functional consequence of reduced gas trapping following
bronchodilation.
Our pilot
observations demonstrate the potential utility of free-breathing 1H MRI
to measure diaphragm dysfunction and treatment response. Future work will
develop and evaluate the physiological significance of other geometric
properties of the diaphragm (e.g. slope, height, etc.) as well as temporal
information provided by the full breathing cycle (e.g. rate of movement during inspiration
and expiration, discordance between left and right diaphragm).Conclusions
Diaphragm
excursion measured by free-breathing 1H MRI is repeatable after
4-months and increased following bronchodilator in patients with severe asthma.Acknowledgements
No acknowledgement found.References
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