Xilong Liu1, Chantao Huang1, Wentao Hu2, Jie Feng1, Wenjun Qiao1, Sijin Chen1, Bo Liu1, Yongming Dai2, and Yikai Xu1
1Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, 2MR Collaboration, Central Research Institute, United Imaging Healthcare, Shanghai, China
Synopsis
Keywords: Placenta, Diffusion/other diffusion imaging techniques
Currently,
antenatal noninvasive imaging techniques to directly evaluate placental function
remains challenge. The objective of this study was using diffusion-relaxometry
correlated spectrum imaging (DR-CSI) as a tool to probe the possible placental
composition changes over gestation in normal pregnancy. Four to five peaks were
visible in the D-T2 spectrum for most subjects. DR-CSI compartments were
defined according to peak distribution. Significant correlation between DR-CSI
compartment volume fractions and
GA was found. We suggested that the DR-CSI technique could be used to reveal
features of placental composition.
Introduction
Placenta plays a vital role
for fetal growth and development during pregnancy. Major pregnancy
complications, such as fetal growth restriction, preeclampsia, and preterm
birth, have been linked with placental dysfunction [1-3]. However, current
antenatal assessment of placental function is limited. Placental MRI, which can
provide in vivo assessment of the placenta structure and function, is emerging
as a technique with substantial promise to overcome some disadvantages of
ultrasound. Diffusion-relaxometry correlation spectrum imaging (DR-CSI) provides
both spectral and spatial information for different intra-voxel compositions. This
study is aimed to 1) Obtain the typical characteristics of D-T2 spectrum for
healthy placenta; 2) elucidate the possible placental composition change over
gestation in normal pregnancy using DR-CSI.Methods
Forty singleton
pregnancies, with a mean ± SD (range) GA 30.27±3.28 (23-36) weeks at time
of examination, were included. Estimated fetal weight (eFW)
was calculated according to an ultrasound examination. All MRI examinations
were performed on a 3.0T scanner (uMR780, United Imaging Healthcare, Shanghai,
China). DR-CSI scans were performed using spin-echo echo-planar diffusion-weighted-imaging
(SE-EP-DWI) sequence, with 7 b-values (01, 101, 251,
1001, 2001, 6001, 10002 s/mm2)
combining 4 TEs (78, 114, 150, 184 ms). Acquired DR-CSI signal of a particular
voxel i is
Si (b,TE )= ∫∫ fi(D,T2)*e-bD*e-TE/T2
dD dT2
where
fi is spectral intensity representing the compositional
distribution in D-T2 dimensions. Regions of interests (ROIs) were defined
inside placenta on all 5 slices. Spectra were constructed in the range: D
0.3~300 μm2/ms, T2 of 0~150 ms. All spectra were segmented into 9
compartments, A1(low D, short T2), A2(low D, mediate T2), A3(low D, long T2),
B1(mediate D, short T2) …C3(high D, long T2) by 4 boundaries (decided by
general peak distribution): 5, 100 μm2/ms for D and 50, 100 ms for
T2 (Figure 1).
Volume fraction Vm of each
compartment m was obtained voxel-by-voxel, and mean Vm
of whole ROI was calculated for each participant. Inter-class coefficient (ICC)
was used to assess the inter-observer agreement. ICC>0.8 was defined as
good. The relationships of Vm to GA and eFW were evaluated by
Pearson correlation. A p-value <0.05
was regarded statistically significant.Results
Four
to five peaks could be observed in the spectrum for most subjects (Figure 1). Three peaks could be observed at low T2
(<50ms), with totally different diffusivity (< 101, ~ 101
and > 102 μm2/s separately). Another one or two peaks
could be observed at low diffusivity (~ 2μm2/s) and longer T2
(>50ms).
After
spectra segmentation. Compartment A1(averaged 35.5±11.2% for the
whole cohort), B1(23.9±6.6%), C1(14.0±5.0%), A2(13.4±8.3%) and A3(6.3±6.2%)
have nonnegligible volume fractions. Other
compartments (B2, C2, B2, C3) showed low concentration (average V<3%) and
were excluded for further analysis. Inter-observer agreement was good for all Vm. DR-CSI VA1 (r=0.633,
p<0.001), VB1 (r=0.358,
p=0.023), VC1 (r=0.411,
p=0.008) showed positive correlation with GA. VA2 (r=−0.465, p=0.003) and VA3 (r=−0.653, p<0.001) showed negative
correlation with GA (Figure 2). VA1 (r=0.482, p=0.002)
and VA3 (r=−0.473,
p=0.003) showed significant correlation with eFW. No significant correlation
was found for eFW to VA2, VB1 and VC1 (Figure 3). Vm mappings were obtained for
each participant.Discussion
Placenta
has two different and non-contacting circulations. The fetal circulation is
intra-capillary and has relatively high-velocity flow and a low oxygen
saturation, whilst the maternal circulation is a low-velocity and a
highly-saturated blood pool but is extra-vascular in the human placenta [4,5]. Therefore,
the compartments A2, A3 (mediate/high T2, low D) should be associated to
slow-moving maternal blood, whereas the compartment C1 (low T2 and high D) should
be associated with fetal blood. The fluid across the fetal-maternal barrier,
which experiences active filtration in the trophoblast compartment, was
considered to display an intermediate diffusivity in previous studies [6,7]. Thus,
it is reasonable to associate compartment B1 to this filtrating flow. Finally,
the signal contribution from compartment A1 (low T2, low D), would be
associated with the dense tissue. Notice that spectra intensity of ultra-low
diffusivity (<1μm2/s) was concentrated in A1, possibly explained
by cellularity-induced restriction.
As
the placenta grows and matures, the diffusion, perfusion, and heterogeneity of
the placenta change accordingly. The correlation between DR-CSI Vm
and GA may be explained by the normal placental maturation, which includes
morphologic changes evolving during gestation, such as increase in number of
terminal villi, vascular surface area, decrease in average vessel diameter, and
increase intervillous fibrin deposition [8,9]. Additionally, the change in the
fraction between maternal and fetal blood also contributes to the evolution of
diffusivity and relaxometry [10].Conclusion
D-T2
spectra and volume fraction mappings for normal placenta were obtained.
Correlation of possible placenta composition with gestation were obtained,
suggesting its potential for assessing placental function during pregnancy.Acknowledgements
We
thank all the women who participated in the study, their obstetricians involved
in study recruitment. The authors express their appreciation to their
volunteers for participating in this study.References
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