Role of MRI to Examine Brain Structural, Metabolic, Hemodynamic, and Functional Deficits in Adults After Heart Failure
Rajesh Kumar1
1Anesthesiology, Radiology, and Bioenginnering, University of California at Los Angeles, Los Angeles, CA, United States

Synopsis

Novel MRI procedures and analytical methods offer a unique opportunity to assess the brain structural, metabolic, hemodynamic, blood brain barrier, resting-state functional connectivity, and functional responses to autonomic challenges status in heart failure (HF) subjects. In a series of experiments in patients with HF, we characterized brain injury, abnormal metabolites, hemodynamics, resting-state functional connectivity, and abnormal functional responses to autonomic challenges, in autonomic, mood, and cognitive control sites, functions that are deficient in HF. Also, potential pathological mechanisms, including compromised CBF and BBB function, contributing to brain damages in HF will be discussed.

Novel magnetic resonance imaging procedures and analytical methods offer a unique opportunity to assess the brain structural, metabolic, hemodynamic, blood brain barrier, resting-state functional connectivity, and functional responses to autonomic challenges status in heart failure (HF) subjects. In a series of experiments in patients with heart failure, we characterized brain injury, abnormal metabolites, hemodynamics, resting-state functional connectivity, and abnormal functional responses to autonomic challenges, in autonomic, mood, and cognitive control sites, functions that are deficient in the condition. Also, potential pathological mechanisms, including compromised cerebral blood flow and blood brain barrier function, contributing to brain damages in HF subjects will be discussed. In addition, various analytical procedures will also be described that can be used to other brain conditions.

Acknowledgements

No acknowledgement found.

References

No reference found.
Proc. Intl. Soc. Mag. Reson. Med. 30 (2022)