Body spectroscopy comprises the majority of the use of MR spectroscopy in clinical trials. The goal of this presentation is to provide an overview of the various uses of both proton (1H) and phosphorous (31P) MRS in the liver, muscle, heart, breast, and kidney. For each region, examples of clinical uses will be shown and the primary MRS biomarkers will be described. Technical challenges for each region of the body will also be described. While more advanced methodologies need to be employed, the clinical value of body MRS is clearly evident.