Real-World Solutions: Abbreviated MRI in Clinical Practice I
Jeong Hee Yoon1
1Radiology, Seoul National University Hospital, Seoul, Korea, Republic of

Synopsis

MRI has been the ultimate diagnostic modality for abdominal solid organs, however, relatively low accessibility of MRI due to its cost and scan time is an issue for its wide application and limit its use. Abbreviated MRI has gained a lot of attention to solve the aforementioned issue and broaden the indications of MRI in the future. However, it is not yet implemented in clinical practice due to some limitations. This presentation aims to share the early experience on abbreviated MRI in practice and discuss how abbreviated MRI may be moving forward to be successfully implemented in clinical practice.

MRI has been the ultimate diagnostic modality for abdominal solid organs- liver, pancreas, biliary tumors. However, the workflow of MRI scan has been complex from the scheduling and image interpretation as the recent techniques lead MRI sequences complex and long. So far, the role of MRI has been an ultimate problem-solving tool in clinical practice. However, now the paradigm of medical field is shifting to value-based practice rather than leaning towards new, complex, on-the-edge medical techniques. In this value-based era, the role of MRI should change, by embracing further indications and ameliorating the complex workflow. One of the attempts are abbreviated MRI in body imaging. It refers to MRI scan without several sequences of full-protocol MRI. The eliminated sequences could vary depending on purpose. This can be used for routine diagnostic purpose, as well as for special screening/surveillance purpose as well. There are reports which revealed comparable diagnostic performances between the abbreviated MRI and full protocol MRI for hepatocellular carcinomas (HCCs), liver metastases, pancreas cancers and prostate cancers (1-6). Although the results are promising, the abbreviated protocol is not yet clinically implemented due to several reasons. First, the optimal protocol is not established yet: For example, suggested protocols for HCC surveillance vary from non-contrast MRI to extracellular agent-enhanced MRI or hepatocyte-specific contrast media-enhanced MRI. Second, the comparative efficacy is limitedly reported. Several studies compared full protocol MRI and abbreviated MRI for diagnosis, but in case of cancer surveillance, the comparison should be between the standard of care protocol (e.g. ultrasound) and the abbreviated MRI. Further, retrospective study cannot reflect the actual incidence of diseases and the predictive diagnostic yield of abbreviated MRI protocol is not clearly addressed yet. Next, reporting balancing sensitivity and specificity should be studied since MRI is an expensive modality as a surveillance tool, and diagnostic modalities after abbreviated MRI would be more expensive and invasive such as endoscopic ultrasound or biopsy. Lastly, reducing sequence may not be sufficient to maintain the diagnostic accuracy and reduce the scan time. Reducing sequence should be performed with adopting new techniques to accelerate the total scan time. The recommendation for protocol, cost, comparative efficacy comparing with standard of care protocol and reporting are needed to be addressed to implement it in clinical practice. In this talk, I will share my experience of abbreviated MRI for cancer surveillance and discuss how to translate this protocol to real clinical practice in the future in an inter-active manner.

Acknowledgements

NRF-2020R1A2C2006031/National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT)

NRF-2021R1C1C1004569/Bio & Medical Technology Development Program of National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT)

References

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2. Huang DQ, Fowler KJ, Liau J, et al. Comparative efficacy of an optimal exam between ultrasound versus abbreviated MRI for HCC screening in NAFLD cirrhosis: A prospective study. Alimentary pharmacology & therapeutics 2022;55(7):820-827. doi: 10.1111/apt.16844

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5. Yamaguchi T, Sofue K, Ueshima E, et al. Abbreviated Gadoxetic Acid-Enhanced MRI for the Detection of Liver Metastases in Patients With Potentially Resectable Pancreatic Ductal Adenocarcinoma. Journal of magnetic resonance imaging : JMRI 2022. doi: 10.1002/jmri.28059

6. Brembilla G, Giganti F, Sidhu H, et al. Diagnostic Accuracy of Abbreviated Bi-Parametric MRI (a-bpMRI) for Prostate Cancer Detection and Screening: A Multi-Reader Study. Diagnostics (Basel) 2022;12(2). doi: 10.3390/diagnostics12020231

Proc. Intl. Soc. Mag. Reson. Med. 30 (2022)