Human MRS: Advances, Challenges & Strategies

Itamar Ronen¹
¹Brighton and Sussex Medical School, United Kingdom

Synopsis

Educational lecture on proton and non-proton MRS in humans

This lecture will provide a broad survey of the use of magnetic resonance spectroscopy in humans. Selected topics that will be mentioned are:
1. Proton MRS in humans: basic/clinical research and potential diagnostic value.
2. Non-proton MRS in humans: 31P, 13C and 2H.
3. MRS beyond concentrations: relaxation times and diffusion coefficients of metabolites as markers for cellular microenvironment.
For each topic, several examples will be provided, and the promises and challenges of each methodology will be discussed.

Acknowledgements

No acknowledgement found.

References

Representative and very incomplete list of useful reviews and articles:

1. Oz G et al., Clinical proton MR spectroscopy in central nervous system disorders. Radiology. 2014 Mar;270(3):658-79. doi: 10.1148/radiol.13130531. PMID: 24568703; PMCID: PMC4263653.

2. Hangel G et al., Emerging methods and applications of ultra-high field MR spectroscopic imaging in the human brain. Anal Biochem. 2022 Feb 1;638:114479. doi: 10.1016/j.ab.2021.114479. Epub 2021 Nov 24. PMID: 34838516.

3. Heerschap, A. et al., (1999). Introduction to in vivo 31P magnetic resonance spectroscopy of (human) skeletal muscle. Proceedings of the Nutrition Society, 58(4), 861-870. doi:10.1017/S0029665199001160

4. De Feyter HM, de Graaf RA. Deuterium metabolic imaging - Back to the future. J Magn Reson. 2021 May;326:106932. doi: 10.1016/j.jmr.2021.106932. PMID: 33902815; PMCID: PMC8083995.

5. Palombo M, et al., Insights into brain microstructure from in vivo DW-MRS. Neuroimage. 2018 Nov 15;182:97-116. doi: 10.1016/j.neuroimage.2017.11.028. Epub 2017 Nov 16. PMID: 29155183.

Proc. Intl. Soc. Mag. Reson. Med. 30 (2022)