The COVID-19 pandemic has led to substantially elevated stress for many people, and especially pregnant individuals. Prenatal stress, including depression and anxiety symptoms, can have negative consequences for infants and children, including structural and functional brain alterations, as well as a higher risk of behaviour problems. I co-lead a Canada-wide study of mental and physical health, life changes, and birth/infant outcomes: Pregnancy during the COVID-19 Pandemic. Here, I will present our structural and functional neuroimaging findings in a group of infants born during the pandemic, in relation to their prenatal stress.