This lecture will cover the imaging spectrum of adult and pediatric brain tumors with rich clinical case material, implementation of quantitative and advanced MRI techniques, and practical tips regarding diagnostic pearls and pitfalls. In addition, we will review key molecular pathways and genomic signatures relevant to patient diagnosis and management. Finally, we will introduce the concept of imaging genomics with examples of genotype-phenotype correlation, radiogenomics and deep learning, and emerging theranostic approaches.