Role of Whole-Body MRI in Pediatric Cancer Predisposition Syndromes
Martin Kyncl1, Michal Zapotocky2, and David Sumerauer3
1Department of Radiology, Second Medical Faculty Charles University & Motol University Hospital, Prague, Czech Republic, 2Department of Paediatric Haematology and Oncology, 2nd Medical Faculty Charles University and Motol University Hospital, Prague, Czech Republic, 3Department of Paediatric Haematology and Oncology, 2nd Medical Faculty Charles University and University Hospital Motol, Prague, Czech Republic

Synopsis

With the advances in genetic testing, more children are being diagnosed with cancer predisposition syndromes. Patients with these syndromes are at increased risk of developing malignancies. Whole-body MRI is a powerful and radiation-free imaging modality for the detection of pathologies in multiple organs with wide anatomical coverage. There is no established consensus for a standardized pediatric MRI protocol that provides high diagnostic accuracy while achieving time efficiency. We provide a reflection on the protocols suitable for MRI imaging in children with cancer predisposition syndromes at present, the necessary anatomical coverage, the types of sequences, the incorporation of dedicated imaging protocols.

Pediatric cancer predisposition syndromes comprise a group of diseases characterized by specific tumors of children and adolescents, suggesting a genetic cancer susceptibility condition. Cancer predisposition syndromes are associated with significant morbidity and mortality. Surveillance and early detection of cancer in individuals carrying a germline cancer predisposing mutation may result in improved outcomes. Several guidelines recommend the use of whole-body MRI for cancer screening in these patients. However, there is a lack of consistency in the design of cancer whole-body MRI surveillance regimens, screening protocols differ among syndromes.

Acknowledgements

No acknowledgement found.

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Proc. Intl. Soc. Mag. Reson. Med. 30 (2022)