Biological & Physiological Considerations in Preclinical Cancer Imaging
Renuka Sriram1
1University of California, San Francisco, San Francisco, CA, United States
Synopsis
The goal of this educational session is to provide an overview of the use of murine cancer models, the associated imaging protocols and its impact on biological and physiological processes. This will help the audience better understand the potentials and the shortcomings of the choices pertaining to in vivo tumor models for imaging studies of cancer development, progression and therapy.
Syllabus
reclinical MRI plays a vital role in developing imaging approaches for improved cancer diagnoses, characterization and the assessment of therapeutic efficacy. MRI is uniquely positioned to yield not only morphological assessment, but also quantitative physiologic, functional, molecular and metabolic readouts of tumor biology and treatment effects. However, the advantage of noninvasive longitudinal in vivo MRI to study disease development and progression involves the use of specific procedures such as anesthesia, animal preparation and injection of molecular probes and contrast agents. In this course we will discuss the biological and physiological impacts of preclinical imaging procedures (with an emphasis on murine models) that maximize the robustness and efficacy of tumor biology and treatment response studies. As a result of attending this course, participants will understand the implications on preclinical cancer imaging of the;Choice of animal models for cancer application of disease development, progression and therapyAnimal handling – anesthesia, circadian rhythm, feeding, invasive procedures, housing conditionsPhysiologic monitoringDosing routes and concentrationInjectables such as contrast agent and molecular probesAcknowledgements
No acknowledgement found.References
No reference found.
Proc. Intl. Soc. Mag. Reson. Med. 30 (2022)