We are now beginning to understand how intracranial pressure gradients, and intracranial pressure transients, propel the cerebrospinal fluid circulation and contributes to cerebrospinal fluid-based brain clearance. This talk reviews approaches to study cerebrospinal fluid flow and pulsatility across different frequency regimes of relevance (bulk flow, respiration, cardiac) and characterize the interplay between intracranial vascular and cerebrospinal fluid compartments. Special attention is devoted to the prospect of non-invasively measuring intracranial pulse pressure and pressure.