Maria Fernandez-Seara1
1Clínica Universidad de Navarra, Spain
Synopsis
The objective of this talk is to introduce and
describe the methodology followed to generate the technical recommendations for
acquisition, processing, and analysis of renal ASL data in the human kidney. The recommendations were developed
employing a seven-stage process: (1) formation of the expert panel; (2)
definition of the context of use; (3) literature review; (4) collection and
comparison of MRI protocols; (5) consensus generations by an approximate Delphi
method; (6) reporting of results in vendor-neutral and vendor-specific terms;
(7) on-going review and updating.
Target audience
Scientists and clinicians interested in learning about
consensus formation through the Delphi process and white paper writing.OUTCOME/Objectives
The objective of this talk is to introduce and
describe the methodology followed to generate the technical recommendations for
acquisition, processing, and analysis of renal ASL data in the human kidney.
Upon attendance, the audience should have a basic understanding of the steps followed
to develop these guidelines.Functional
renal MRI techniques have shown significant potential for clinical utility. However, to pave the
way for their use in clinical trials and ultimately in clinical practice,
effort must be made to standardize the acquisition and data processing methods
and improve the reproducibility of the measurements.
The PARENCHIMA action (renalmri.org)
is a multidisciplinary network of clinical and basic scientist that was funded
for 4 years by the European Cooperation in Science and Technology (COST), whose
aim is to eliminate the main barriers to the clinical translation of functional
renal MRI techniques, among then, ASL. In the field of ASL PARENCHIMA’s efforts
have translated into a comprehensive review paper highlighting the potential of
renal ASL for clinical applications (Odudu et al. 2018) and into a consensus
paper on technical recommendations for the clinical translation of the
technique in the kidney (Nery et al. 2020), as a first step towards
standardization. These recommendations were developed by consensus by a group
of 23 international clinical and non-clinical experts in the field and
comprised guidelines for data acquisition, processing, and analysis. These
recommendations are meant to be updated as more evidence becomes available.
The recommendations were developed
employing a seven-stage process: (1) formation of the expert panel; (2)
definition of the context of use; (3) literature review; (4) collection and
comparison of MRI protocols; (5) consensus generations by an approximate Delphi
method; (6) reporting of results in vendor-neutral and vendor-specific terms;
(7) on-going review and updating.
A similar process was followed
to develop recommendations for DWI, BOLD, T1 and T2 mapping and phase-contrast
MRI (Mendichovszky et al. 2020).Acknowledgements
Government of Navarra, under
the frame of ERA PerMed (ERAPERMED2020-326 - RESPECT) and under the Grant:
PC181-182 RM-RENAL.References
Mendichovszky I., Pullens P., et al. (2020). Technical recommendations for clinical
translation of renal MRI: a consensus project of the Cooperation in Science and
Technology Action PARENCHIMA. Magn Reson Mater Phy 33(1):131-140.
Nery F., Buchanan C. E., et al. (2020). Consensus-based
technical recommendations for clinical traslation of renal ASL MRI. Magn
Reson Mater Phy 33(1):141-161.
Odudu, A., Nery, F., et al. (2018). Arterial spin
labelling MRI to measure renal perfusion: a systematic review and statement paper.
Nephrol Dial Transplant 33(suppl_2):ii15-ii21.