Vascular imaging has been widely used in clinical routine practice. Arterial spin labeling (ASL) and vascular space occupancy (VASO) are two non-invasive vascular MRI techniques that enable measuring cerebral blood flow (CBF) and cerebral blood volume (CBV), respectively, without the use of exogenous tracers. Given the complete non-invasive profile, ASL and VASO have been demonstrated as useful vascular imaging tools in some selected clinical applications, such as stroke, vascular malformation, tumor, and neurodegenerative diseases, etc. This talk will review the current state of clinical applications using ASL and VASO.