The management of Crohn’s disease (CD) has entered a new era in which it is imperative to incorporate objective data and symptoms to plan the best therapeutic approach for each patient. Magnetic resonance (MR) imaging provides a comprehensive insight into the disease process, and its high accuracy for detecting inflammation make it essential for diagnosis and management. Growing evidence indicates that MR provides an accurate information that enables monitorization of CD. In this lecture we will review the current MR biomarkers and indexes for assessing CD activity and damage.