The pediatric brain undergoes dramatic changes during development. Neuroimaging techniques, such as diffusion MRI and perfusion MRI, provide unprecedented opportunities to noninvasively quantify the brain changes in a pediatric population at both global and regional levels. These MRI methods offer a wealth of structural, functional, and physiological brain properties that could be used as biomarkers. This talk will briefly review the applications of diffusion and perfusion MRI technologies in brain development, as well as pediatric diseases and disorders such as autism, with protocols/pipelines tailored to pediatric populations.